Symbol Name ID |
Dicer1
dicer 1, ribonuclease type III MGI:2177178 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Subacute progressive viral hepatitis |
Disease(s) Associated with DICER1 | |
hepatocellular carcinoma |
Mouse Phenotypes | immune system phenotype |
blood vessel inflammation |
increased T cell apoptosis |
abnormal granulocyte differentiation |
decreased T cell proliferation |
abnormal thymus morphology |
abnormal thymus development |
abnormal thymus epithelium morphology |
abnormal thymus cortex morphology |
abnormal thymus medulla morphology |
athymia |
decreased thymocyte number |
abnormal thymus physiology |
abnormal thymus involution |
enlarged spleen |
decreased immature B cell number |
abnormal immunoglobulin V(D)J recombination |
increased pro-B cell number |
arrested B cell differentiation |
abnormal positive T cell selection |
decreased neutrophil cell number |
abnormal neutrophil morphology |
decreased germinal center B cell number |
decreased mature B cell number |
absent memory B cells |
absent plasma cells |
increased B-1 B cell number |
decreased B cell number |
decreased pre-B cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased gamma-delta T cell number |
decreased regulatory T cell number |
decreased T cell number |
decreased single-positive T cell number |
decreased leukocyte cell number |
abnormal effector T cell morphology |
abnormal regulatory T cell morphology |
abnormal myeloid leukocyte morphology |
abnormal splenic cell ratio |
absent spleen |
abnormal germinal center B cell physiology |
decreased immunoglobulin level |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
abnormal cytotoxic T cell physiology |
abnormal regulatory T cell physiology |
abnormal lymph node cell ratio |
enlarged lymph nodes |
abnormal humoral immune response |
increased susceptibility to induced arthritis |
liver inflammation |
lung inflammation |
increased susceptibility to Herpesvirales infection |
decreased susceptibility to Riboviria infection |
increased susceptibility to Riboviria infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1m1Btlr/Dicer1m1Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1tm1b(EUCOMM)Wtsi/Dicer1+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1tm1Bdh/Dicer1tm1Bdh Tg(Cd4-cre)1Cwi/0 (conditional) |
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Dicer1tm1Bdh/Dicer1tm1Bdh Foxp3tm4(YFP/icre)Ayr/Y (conditional) |
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Dicer1tm1Bdh/Dicer1tm1Bdh Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr (conditional) |
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Dicer1tm1Bdh/Dicer1tm1Bdh Tg(Foxp3-EGFP/icre)1aJbs/0 (conditional) |
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Dicer1tm1Bdh/Dicer1tm1Bdh H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Dicer1tm1Bdh/Dicer1tm1Bdh Aicdatm1(cre)Njen/Aicda+ (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1tm1Dli/Dicer1tm1Dli Tg(Cd4-cre)1Cwi/? (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dicer1tm1Mmk/Dicer1tm1Mmk Tg(Lck-cre)1Cwi/0 (conditional) |
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Dicer1tm1Mmk/Dicer1tm1Mmk Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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Dicer1tm1Mmk/Dicer1tm1Mmk Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional) |
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Dicer1tm1Tara/Dicer1tm1Tara Foxn1tm3(cre)Nrm/Foxn1+ (conditional) |
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Dicer1tm1Mmk/Dicer1tm1.1Mmk Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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Dicer1tm1Bdh/Dicer1+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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