Symbol
Name
ID

Nlrc4
NLR family, CARD domain containing 4
MGI:3036243

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

enlarged spleen

increased neutrophil cell number

increased T cell number

abnormal spleen morphology

increased splenocyte number

abnormal macrophage physiology

increased circulating interleukin-1 beta level

increased circulating interleukin-17 level

abnormal cytokine secretion

decreased interleukin-1 beta secretion

increased interleukin-1 beta secretion

decreased inflammatory response

increased inflammatory response

joint inflammation

arthritis

skin inflammation

dermatitis

abnormal response to infection

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Nlrc4^em1Vnce/Nlrc4^em1Vnce

Nlrc4^em2Vnce/Nlrc4^em2Vnce

Nlrc4^em3Vnce/Nlrc4^em3Vnce

Nlrc4^m1Btlr/Nlrc4^m1Btlr

Nlrc4^tm1Gln/Nlrc4^tm1Gln

Nlrc4^tm1Gne/Nlrc4^tm1Gne

Nlrc4^tm1Nnz/Nlrc4^tm1Nnz

Nlrc4^tm1Vmd/Nlrc4^tm1Vmd

Nlrc4^m1Btlr/Nlrc4⁺

Tg(Cd74-Nlrc4*)1Kyas/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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