Symbol Name ID |
B2m
beta-2 microglobulin MGI:88127 |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal circulating IgA level |
Decreased circulating IgG level |
Abnormal circulating IgM level |
Decreased specific antibody response to polysaccharide vaccine |
B lymphocytopenia |
Reduced natural killer cell count |
Abnormal lymph node morphology |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Lung abscess |
Skin rash |
Recurrent respiratory infections |
Disease(s) Associated with B2M | |||||||||||||
familial visceral amyloidosis | |||||||||||||
immunodeficiency 43 |
Mouse Phenotypes | insulitis |
abnormal T cell number |
increased T-helper 1 cell number |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
increased gamma-delta T cell number |
increased gamma-delta intraepithelial T cell number |
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology |
decreased IgG level |
increased IgM level |
abnormal cytotoxic T cell physiology |
abnormal interleukin level |
abnormal tumor necrosis factor level |
decreased level of surface class I molecules |
increased interleukin-3 secretion |
decreased interleukin-4 secretion |
increased tumor necrosis factor secretion |
decreased susceptibility to autoimmune diabetes |
decreased susceptibility to bacterial infection |
increased susceptibility to infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
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Availability | Mouse Genotype | |||||||||||||||||||||
B2mtm1Jae/B2mtm1Jae | ||||||||||||||||||||||
B2mtm1Unc/B2mtm1Unc | ||||||||||||||||||||||
B2mtm1Unc/B2mtm1Unc Tg(GFAP-B2m)9Mdos/? |
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B2mtm1Unc/B2mtm1Unc Tg(GFAP-B2m)#Mdos/? |
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B2mtm1Unc/B2m+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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