Symbol Name ID |
Cd28
CD28 antigen MGI:88327 |
Darker colors indicate more annotations |
Human Phenotypes | Autoimmunity |
Disease(s) Associated with CD28 | |
type 1 diabetes mellitus |
Mouse Phenotypes | increased T cell apoptosis |
decreased T cell proliferation |
increased T cell proliferation |
increased splenocyte proliferation |
enlarged thymus |
enlarged spleen |
abnormal lymphopoiesis |
abnormal class switch recombination |
increased B cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
decreased regulatory T cell number |
decreased T cell number |
increased activated T cell number |
increased leukocyte cell number |
decreased spleen germinal center number |
abnormal germinal center B cell physiology |
abnormal immunoglobulin level |
decreased IgG1 level |
decreased IgG2a level |
increased IgG2a level |
decreased IgG2b level |
decreased IgM level |
decreased immunoglobulin level |
abnormal NK cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
abnormal cytotoxic T cell physiology |
abnormal regulatory T cell physiology |
decreased circulating interferon-gamma level |
decreased circulating interleukin-4 level |
enlarged lymph nodes |
increased susceptibility to type I hypersensitivity reaction |
decreased susceptibility to type IV hypersensitivity reaction |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-12 secretion |
decreased interleukin-2 secretion |
decreased interleukin-4 secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
increased susceptibility to autoimmune disorder |
increased susceptibility to autoimmune diabetes |
increased susceptibility to experimental autoimmune encephalomyelitis |
brain inflammation |
skin inflammation |
abnormal response to transplant |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1a(EUCOMM)Hmgu/Cd28tm1a(EUCOMM)Hmgu | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1Jmg/Cd28tm1Jmg | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1Mak/Cd28tm1Mak | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1Pjl/Cd28tm1Pjl | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1Shr/Cd28tm1Shr | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1Jmg/Cd28tm1Mak | |||||||||||||||||||||||||||||||||||||||||||||||||
Cd28tm1.1Huen/Cd28tm1.1Huen Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
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Cd28tm1Ltu/Cd28tm1Ltu Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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