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Symbol
Name
ID

Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Polyclonal elevation of IgM

Sinusitis

Chronic sinusitis

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Ulcerative colitis

Celiac disease

Peritoneal abscess

Hepatitis

Pancreatitis

Thyroiditis

Uveitis

Abnormality of the immune system

Acute infectious pneumonia

Recurrent pneumonia

Autoimmunity

Asthma

Nontuberculous mycobacterial pulmonary infection

Recurrent Burkholderia cepacia infections

Recurrent Haemophilus influenzae infections

Recurrent Staphylococcus aureus infections

Recurrent Aspergillus infections

Recurrent respiratory infections

Recurrent bronchopulmonary infections

Recurrent lower respiratory tract infections

Disease(s) Associated with CFTR

allergic bronchopulmonary aspergillosis

asthma

bronchiectasis

cystic fibrosis

pancreatic cancer

primary sclerosing cholangitis

Mouse Phenotypes		peritoneal inflammation	abnormal thymus involution	spleen hyperplasia	decreased neutrophil cell number	abnormal alveolar macrophage morphology	gallbladder inflammation	lung inflammation	increased susceptibility to bacterial infection	increased susceptibility to bacterial infection induced morbidity/mortality	increased susceptibility to infection
Availability	Mouse Genotype	peritoneal inflammation	abnormal thymus involution	spleen hyperplasia	decreased neutrophil cell number	abnormal alveolar macrophage morphology	gallbladder inflammation	lung inflammation	increased susceptibility to bacterial infection		increased susceptibility to infection
	Cftr^tm1Cam/Cftr^tm1Cam
	Cftr^tm1Hgu/Cftr^tm1Hgu
	Cftr^tm1Kth/Cftr^tm1Kth
	Cftr^tm1Unc/Cftr^tm1Unc
	Cftr^tm2Cam/Cftr^tm2Cam
	Cftr^tm2Mrc/Cftr^tm2Mrc
	Cftr^tm3Hgu/Cftr^tm3Hgu
	Cftr^tm3Mrc/Cftr^tm3Mrc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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