Symbol
Name
ID

Igh
immunoglobulin heavy chain complex
MGI:96442

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased B cell apoptosis

abnormal B cell proliferation

increased B cell proliferation

insulitis

abnormal B cell differentiation

abnormal class switch recombination

decreased immature B cell number

decreased transitional stage B cell number

decreased transitional stage T2 B cell number

abnormal immunoglobulin V(D)J recombination

abnormal immunoglobulin heavy chain V(D)J recombination

abnormal immunoglobulin light chain V-J recombination

increased early pro-B cell number

decreased late pro-B cell number

increased late pro-B cell number

increased pro-B cell number

abnormal somatic hypermutation frequency

arrested B cell differentiation

abnormal B cell number

decreased mature B cell number

absent mature B cells

absent B-1 B cells

absent B-1a cells

absent B-1b cells

decreased B-1a cell number

decreased B-1b cell number

decreased follicular B cell number

absent follicular B cells

decreased marginal zone B cell number

absent marginal zone B cells

absent plasma cells

increased marginal zone B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

absent pre-B cells

increased B cell number

increased pre-B cell number

abnormal B cell morphology

abnormal mature B cell morphology

abnormal B-1 B cell morphology

abnormal marginal zone B cell morphology

abnormal spleen morphology

spleen hypoplasia

absent spleen germinal center

abnormal B cell physiology

abnormal B cell activation

abnormal immunoglobulin level

decreased IgA level

increased IgA level

decreased IgD level

decreased IgE level

increased IgE level

decreased IgG1 level

increased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

increased IgG3 level

decreased IgG level

increased IgG level

decreased IgM level

increased IgM level

decreased immunoglobulin level

abnormal marginal zone B cell physiology

abnormal gut-associated lymphoid tissue morphology

abnormal Peyer's patch germinal center morphology

abnormal lymph node germinal center morphology

abnormal immune system physiology

abnormal humoral immune response

increased susceptibility to autoimmune diabetes

increased anti-nuclear antigen antibody level

increased anti-single stranded DNA antibody level

Availability

Mouse Genotype

Igh^deltaD/Igh^deltaD

Igh^tm1.1Hmj/Igh^tm1.1Hmj

Igh^tm1.1Hws/Igh^tm1.1Hws

Igh^tm1.1Rsky/Igh^tm1.1Rsky

Igh^tm1.1Twin/Igh^tm1.1Twin

Igh^tm1.1Vmd/Igh^tm1.1Vmd

Igh^tm1.2Rsky/Igh^tm1.2Rsky

Igh^tm1Aak/Igh^tm1Aak

Igh^tm1Cog/Igh^tm1Cog

Igh^tm1Emo/Igh^tm1Emo

Igh^tm1Ktom/Igh^tm1Ktom

Igh^tm1Mnz/Igh^tm1Mnz

Igh^tm2.1Fwa/Igh^tm2.1Fwa

Igh^tm2.1Hws/Igh^tm2.1Hws

Igh^tm2Cog/Igh^tm2Cog

Igh^tm2Emo/Igh^tm2Emo

Igh^tm2Mnz/Igh^tm2Mnz

Igh^tm3.1Cog/Igh^tm3.1Cog

Igh^tm3Cgn/Igh^tm3Cgn

Igh^tm3Hws/Igh^tm3Hws

Igh^tm4.1Cog/Igh^tm4.1Cog

Igh^tm4.1Fwa/Igh^tm4.1Fwa

Igh^tm5.1Cgn/Igh^tm5.1Cgn

Igh^tm5.1Cog/Igh^tm5.1Cog

Igh^tm5.1Fwa/Igh^tm5.1Fwa

Igh^tm5Cgn/Igh^tm5Cgn

Igh^tm6Fwa/Igh^tm6Fwa

Igh^tm7.1Fwa/Igh^tm7.1Fwa

Igh^tm11.1Cgn/Igh^tm11.1Cgn

Igh^tm12Cgn/Igh^tm12Cgn

Igh^deltaD/Igh⁺

Igh^tm1.1Lnit/Igh⁺

Igh^tm1.1Twin/Igh⁺

Igh^tm1.1Vmd/Igh⁺

Igh^tm1.2Rsky/Igh⁺

Igh^tm1Cgn/Igh⁺

Igh^tm1Cgn/Igh^tm2Cgn

Igh^tm1Kplm/Igh⁺

Igh^tm1Kplm/Igh^tm3Cgn

Igh^tm1Kplm/Igh^tm4Cgn

Igh^tm1Rbr/Igh⁺

Igh^tm2Cgn/Igh⁺

Igh^tm2Cgn/Igh^tm3Cgn

Igh^tm2Cgn/Igh^tm4.1Fwa

Igh^tm2Cog/Igh⁺

Igh^tm3Cgn/Igh⁺

Igh^tm3Mnz/Igh^tm4.1Mnz

Igh^tm4.1Fwa/Igh⁺

Igh^tm4Cgn/Igh⁺

Igh^tm5.1Fwa/Igh⁺

Igh^{tm7(VHB1-8)Cgn}/Igh⁺

Igh^{tm8(VHB1-8)Cgn}/Igh⁺

Igh^{tm9(VHB1-8)Cgn}/Igh⁺

Tg(Igh3H9)41Mwg/?

Tg(Igh-3VD93)343Ust/?

Tg(IghH280)48Dvs/?

Igh^tm1.2Rsky/Igh^tm1.2Rsky
Tg(CD19-cre/ERT2)1Cgn/? (conditional)

Igh^tm5Cgn/Igh^tm5Cgn
Tg(CD19-cre/ERT2)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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