Symbol Name ID |
Il2rg
interleukin 2 receptor, gamma chain MGI:96551 |
Darker colors indicate more annotations |
Human Phenotypes | Reduced natural killer cell activity |
Decreased circulating IgA concentration |
Decreased circulating IgE concentration |
Decreased circulating IgG concentration |
Decreased circulating total IgM |
Agammaglobulinemia |
T lymphocytopenia |
Impaired lymphocyte transformation with phytohemagglutinin |
Hypoplasia of the thymus |
Chronic oral candidiasis |
Skin rash |
Pneumonia |
Recurrent pneumonia |
Severe combined immunodeficiency |
Recurrent fungal infections |
Recurrent bacterial meningitis |
Disease(s) Associated with IL2RG | ||||||||||||||||
X-linked severe combined immunodeficiency |
Mouse Phenotypes | decreased T cell proliferation |
cecum inflammation |
absent uterine NK cells |
small thymus cortex |
thymus cortex hypoplasia |
thymus hyperplasia |
small thymus |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
enlarged spleen |
spleen hyperplasia |
abnormal class switch recombination |
decreased immature B cell number |
arrested B cell differentiation |
decreased double-negative T cell number |
decreased double-positive T cell number |
abnormal gamma-delta T cell differentiation |
abnormal myelopoiesis |
increased neutrophil cell number |
decreased myeloid dendritic cell number |
abnormal B cell number |
decreased mature B cell number |
decreased plasma cell number |
decreased pre-B cell number |
decreased NK cell number |
absent NK cells |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
absent gamma-delta T cells |
absent gamma-delta intraepithelial T cell |
decreased regulatory T cell number |
decreased T cell number |
decreased single-positive T cell number |
decreased lymphocyte cell number |
increased macrophage cell number |
increased monocyte cell number |
abnormal leukocyte morphology |
abnormal lymphocyte morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal alpha-beta intraepithelial T cell morphology |
spleen hypoplasia |
absent spleen germinal center |
absent spleen white pulp |
decreased spleen white pulp amount |
abnormal splenic cell ratio |
abnormal basophil physiology |
abnormal mast cell physiology |
abnormal immunoglobulin level |
decreased IgE level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
decreased immunoglobulin level |
impaired natural killer cell mediated cytotoxicity |
abnormal immune system cell morphology |
abnormal immune system organ morphology |
abnormal gut-associated lymphoid tissue morphology |
enlarged Peyer's patches |
absent Peyer's patches |
abnormal mesenteric lymph node morphology |
small lymph nodes |
abnormal dendritic cell physiology |
abnormal cell-mediated immunity |
abnormal immune serum protein physiology |
decreased interferon-gamma secretion |
decreased interleukin-2 secretion |
decreased interleukin-4 secretion |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Cgn/Il2rgtm1Cgn | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Krf/Il2rgtm1Krf | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Sug/Il2rgtm1Sug | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Wjl/Il2rgtm1Wjl | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Cgn/Y | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Sug/Y | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1Wjl/Y | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd4-cre)1Cwi/0 (conditional) |
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Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)B8Asin/0 (conditional) |
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Il2rgtm2Cgn/Y Tg(Mx1-cre)1Cgn/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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