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Symbol
Name
ID

Itgb2
integrin beta 2
MGI:96611

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Leukocytosis

Abnormality of neutrophil physiology

Impaired neutrophil chemotaxis

Acute myeloid leukemia

Sinusitis

Periodontitis

Severe periodontitis

Recurrent aphthous stomatitis

Conjunctivitis

Recurrent tonsillitis

Perianal abscess

Rectal abscess

Peritonitis

Otitis media

Vaginitis

Glomerulonephritis

Recurrent urinary tract infections

Recurrent skin infections

Chronic mucocutaneous candidiasis

Chronic oral candidiasis

Osteomyelitis

Pneumonia

Sepsis

BCGosis

Recurrent infections

Recurrent bacterial infections

Recurrent gram-negative bacterial infections

Recurrent staphylococcal infections

Recurrent fungal infections

Meningitis

Disease(s) Associated with ITGB2

leukocyte adhesion deficiency

leukocyte adhesion deficiency 1

Mouse Phenotypes

immune system phenotype

abnormal leukocyte migration

abnormal leukocyte adhesion

abnormal T cell proliferation

decreased T cell proliferation

enlarged spleen

abnormal NK cell differentiation

abnormal T cell differentiation

myeloid hyperplasia

increased basophil cell number

increased eosinophil cell number

decreased neutrophil cell number

increased neutrophil cell number

increased granulocyte number

abnormal neutrophil morphology

decreased dendritic cell number

increased dendritic cell number

increased B-1b cell number

decreased B cell number

increased B cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased T-helper 1 cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased NK T cell number

decreased single-positive T cell number

increased T cell number

increased lymphocyte cell number

decreased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

abnormal leukocyte physiology

abnormal neutrophil physiology

impaired neutrophil recruitment

increased IgA level

increased IgE level

decreased IgG level

increased IgG level

increased IgM level

increased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal cytotoxic T cell cytolysis

abnormal T cell activation

increased circulating interleukin-3 level

increased circulating interleukin-6 level

abnormal cytokine level

abnormal immune system cell morphology

enlarged lymph nodes

lymph node hypoplasia

abnormal lymph organ size

decreased susceptibility to type IV hypersensitivity reaction

impaired humoral immune response

increased interferon-beta secretion

decreased interferon-gamma secretion

increased interferon-gamma secretion

decreased acute inflammation

decreased inflammatory response

increased inflammatory response

conjunctivitis

dermatitis

decreased susceptibility to bacterial infection

increased susceptibility to bacterial infection

Availability

Mouse Genotype

Itgb2^M1Btlr/Itgb2^M1Btlr

*

Itgb2^m2Btlr/Itgb2^m2Btlr

Itgb2^m3Btlr/Itgb2^m3Btlr

Itgb2^M4Btlr/Itgb2^M4Btlr

Itgb2^m5Btlr/Itgb2^m5Btlr

Itgb2^tm1.1Arte/Itgb2^tm1.1Arte

Itgb2^tm1Bay/Itgb2^tm1Bay

!

!

Itgb2^tm2Bay/Itgb2^tm2Bay

Itgb2l^tm1Jhws/Itgb2l^tm1Jhws

*

Itgb2^tm1Bay/Itgb2^tm2Bay

!

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24