Symbol Name ID |
Itk
IL2 inducible T cell kinase MGI:96621 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgG concentration |
Decreased circulating antibody concentration |
Autoimmune hemolytic anemia |
Decreased proportion of CD4-positive helper T cells |
Leukopenia |
Hemophagocytosis |
Autoimmune thrombocytopenia |
Stomatitis |
Persistent EBV viremia |
Lymphadenopathy |
Splenomegaly |
Autoimmunity |
Recurrent infections |
Disease(s) Associated with ITK | |||||||||||||
lymphoproliferative syndrome 1 |
Mouse Phenotypes | immune system phenotype |
increased CD8-positive, alpha-beta memory T cell proliferation |
decreased T cell proliferation |
abnormal thymus cell ratio |
enlarged spleen |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal positive T cell selection |
increased double-negative T cell number |
increased germinal center B cell number |
decreased B cell number |
increased B cell number |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta memory T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
increased mature gamma-delta T cell number |
increased memory T cell number |
decreased T cell number |
abnormal T cell morphology |
abnormal NK T cell morphology |
abnormal gamma-delta T cell morphology |
abnormal spleen morphology |
increased IgE level |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal T cell activation |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
increased interleukin-10 secretion |
increased interleukin-13 secretion |
decreased interleukin-2 secretion |
increased interleukin-4 secretion |
increased susceptibility to parasitic infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
Itkem1(IMPC)Mbp/Itkem1(IMPC)Mbp | ||||||||||||||||||||||||||||||||||||||||
Itkm1Btlr/Itkm1Btlr | ||||||||||||||||||||||||||||||||||||||||
Itkm2Btlr/Itkm2Btlr | ||||||||||||||||||||||||||||||||||||||||
Itktm1Lex/Itktm1Lex | ||||||||||||||||||||||||||||||||||||||||
Itktm1Litt/Itktm1Litt | * | |||||||||||||||||||||||||||||||||||||||
Itktm1Ljb/Itktm1Ljb |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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