Symbol
Name
ID

Kit
KIT proto-oncogene receptor tyrosine kinase
MGI:96677

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cutaneous mastocytosis	Acute myeloid leukemia
Disease(s) Associated with KIT	Cutaneous mastocytosis	Acute myeloid leukemia
acute myeloid leukemia
mastocytosis

Mouse Phenotypes

immune system phenotype

increased mast cell degranulation

large intestinal inflammation

colitis

small intestinal inflammation

decreased thymocyte number

enlarged spleen

spleen hyperplasia

abnormal B cell differentiation

arrested B cell differentiation

abnormal T cell differentiation

decreased basophil cell number

decreased mast cell number

increased mast cell number

abnormal mast cell morphology

decreased B cell number

increased B cell number

spleen hypoplasia

abnormal mast cell physiology

impaired neutrophil recruitment

abnormal interferon level

abnormal interleukin level

decreased susceptibility to type I hypersensitivity reaction

decreased susceptibility to induced arthritis

decreased inflammatory response

kidney inflammation

abnormal response to transplant

Availability

Mouse Genotype

Kit^tm1.1Bsm/Kit^tm1.1Bsm

Kit^tm1Ber/Kit^tm1Ber

Kit^tm1Bpr/Kit^tm1Bpr

Kit^tm1Bsm/Kit^tm1Bsm

Kit^tm2Ber/Kit^tm2Ber

Kit^tm3.1Bsm/Kit^tm3.1Bsm

Kit^tm3Ber/Kit^tm3Ber

Kit^W-Btlr/Kit^W-Btlr

Kit^W-f/Kit^W-f

Kit^W-n/Kit^W-n

Kit^W-vkd/Kit^W-vkd

Kit^Wads/Kit^Wads

Kit^tm2Bsm/Kit⁺

Kit^tm4.1Bsm/Kit⁺

Kit^W-37J/Kit⁺

Kit^W-37J/Kit^W

Kit^W-42J/Kit⁺

Kit^W-42J/Kit^W

Kit^W-Jic/Kit⁺

Kit^W-Jic/Kit^W

Kit^W-n/Kit^W

Kit^W-v/Kit⁺

Kit^W/Kit^W-v

Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)1Roer/0 (conditional)

Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)3Roer/0 (conditional)

Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)1Roer/0 (conditional)

Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)3Roer/0 (conditional)

Tg(Kit*D814V)1Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Tg(Kit*D814V)2Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Tg(Kit*D814V)3Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24