Symbol Name ID |
Lck
lymphocyte protein tyrosine kinase MGI:96756 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgE |
Decreased circulating IgG level |
Decreased circulating total IgM |
Decreased proportion of CD4-positive helper T cells |
Recurrent upper respiratory tract infections |
Pericarditis |
Abscess |
Chronic oral candidiasis |
Panniculitis |
Autoimmunity |
Immunodeficiency |
Recurrent lower respiratory tract infections |
Disease(s) Associated with LCK | |||||||||||||
immunodeficiency 22 |
Mouse Phenotypes | decreased T cell proliferation |
abnormal thymus morphology |
thymus atrophy |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal double-negative T cell morphology |
decreased double-positive T cell number |
abnormal T cell subpopulation ratio |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased gamma-delta T cell number |
decreased gamma-delta intraepithelial T cell number |
abnormal intraepithelial T cell number |
decreased regulatory T cell number |
increased regulatory T cell number |
decreased T cell number |
decreased single-positive T cell number |
increased T cell number |
increased activated T cell number |
increased single-positive T cell number |
abnormal lymphocyte morphology |
abnormal T cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD8-positive, alpha beta T cell morphology |
abnormal alpha-beta intraepithelial T cell morphology |
abnormal single-positive T cell number |
abnormal intraepithelial T cell morphology |
abnormal immunoglobulin level |
decreased IgG1 level |
increased IgG2a level |
increased IgG3 level |
decreased IgG level |
increased IgM level |
decreased cytotoxic T cell cytolysis |
abnormal regulatory T cell physiology |
enlarged lymph nodes |
|
Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
Lckm1Btlr/Lckm1Btlr | |||||||||||||||||||||||||||||||||||||||||
Lckm2Btlr/Lckm2Btlr | |||||||||||||||||||||||||||||||||||||||||
Lckm3Btlr/Lckm3Btlr | |||||||||||||||||||||||||||||||||||||||||
Lcktm1.1Litt/Lcktm1.1Litt | |||||||||||||||||||||||||||||||||||||||||
Lcktm1Dbs/Lcktm1Dbs | |||||||||||||||||||||||||||||||||||||||||
Lcktm1Mak/Lcktm1Mak | |||||||||||||||||||||||||||||||||||||||||
Lcktm1Litt/Lcktm1.1Litt Tnfrsf4tm2(cre)Nik/Tnfrsf4+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/05/2024 MGI 6.24 |
![]() |
|