Symbol Name ID |
Myc
myelocytomatosis oncogene MGI:97250 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Neutropenia |
Decreased proportion of CD4-positive helper T cells |
Leukocytosis |
Leukopenia |
Acute promyelocytic leukemia |
Stomatitis |
Abnormal lymph node morphology |
Lymphadenopathy |
Abnormality of the spleen |
Immunodeficiency |
Chronic infection |
Disease(s) Associated with MYC | |||||||||||
acute promyelocytic leukemia | |||||||||||
Burkitt lymphoma |
Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
decreased B cell proliferation |
increased B cell proliferation |
decreased T cell proliferation |
enlarged thymus |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal lymphopoiesis |
abnormal T cell receptor beta chain V(D)J recombination |
increased B cell number |
increased pre-B cell number |
decreased NK T cell number |
decreased memory T cell number |
decreased T cell number |
increased lymphocyte cell number |
increased macrophage cell number |
increased leukocyte cell number |
spleen hypoplasia |
abnormal NK cell physiology |
abnormal immune system organ morphology |
enlarged lymph nodes |
lymph node hypoplasia |
small lymphoid organs |
lymphoid hypoplasia |
kidney inflammation |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||
Myctm1.1(Nmyc1)Fwa/Myctm1.1(Nmyc1)Fwa | * | |||||||||||||||||||||||||||
Myctm1.1Cksn/Myctm1.1Cksn | * | |||||||||||||||||||||||||||
Myctm1Lbox/Myctm1Lbox | ||||||||||||||||||||||||||||
Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp | ||||||||||||||||||||||||||||
Myctm1Atp/Myc+ | * | |||||||||||||||||||||||||||
Myctm1Atp/Myctm2.1Atp | * | |||||||||||||||||||||||||||
Myctm1Lbox/Myc+ | ||||||||||||||||||||||||||||
Myctm2.1Atp/Myc+ | ||||||||||||||||||||||||||||
Myctm3(Tcrb)Fwa/Myc+ | ||||||||||||||||||||||||||||
Tg(HBB-Myc)#Cos/0 | ||||||||||||||||||||||||||||
Tg(IghMyc)22Bri/0 | ||||||||||||||||||||||||||||
Tg(Pklr-Myc)73Ak/0 | ||||||||||||||||||||||||||||
Tg(IghMyc)22Bri/? | ||||||||||||||||||||||||||||
Myctm2.1Atp/Myctm2.1Atp Tg(Mx1-cre)1Cgn/0 (conditional) |
* | |||||||||||||||||||||||||||
Myctm2Fwa/Myctm2Fwa Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Myctm1Atp/Myctm2.1Atp Tg(Mx1-cre)1Cgn/0 (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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