Symbol Name ID |
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) MGI:98483 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Chronic sinusitis |
Chronic otitis media |
Acute infectious pneumonia |
Autoimmunity |
Asthma |
Recurrent Haemophilus influenzae infections |
Bronchiolitis |
Recurrent lower respiratory tract infections |
Recurrent bronchitis |
Disease(s) Associated with TAP1 | |||||||||
asthma | |||||||||
bronchiectasis | |||||||||
MHC class I deficiency | |||||||||
type 1 diabetes mellitus |
Mouse Phenotypes | immune system phenotype |
decreased double-negative T cell number |
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased T-helper 1 cell number |
decreased CD8-positive, alpha-beta memory T cell number |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
abnormal lymphocyte physiology |
decreased cytotoxic T cell cytolysis |
abnormal dendritic cell antigen presentation |
abnormal antigen presentation |
abnormal antigen presentation via MHC class I |
decreased level of surface class I molecules |
defective assembly of class I molecules |
defective intracellular transport of class I molecules |
decreased susceptibility to bacterial infection |
decreased susceptibility to bacterial infection induced morbidity/mortality |
increased susceptibility to Herpesvirales infection |
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Availability | Mouse Genotype | ||||||||||||||||||
Tap1m1Btlr/Tap1m1Btlr | |||||||||||||||||||
Tap1m2Btlr/Tap1m2Btlr | |||||||||||||||||||
Tap1rose/Tap1rose | |||||||||||||||||||
Tap1tm1Arp/Tap1tm1Arp | |||||||||||||||||||
Tap1tm1Hpl/Tap1tm1Hpl | * |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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