Symbol Name ID |
Tgfb1
transforming growth factor, beta 1 MGI:98725 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Eosinophilia |
Sinusitis |
Chronic sinusitis |
Allergic rhinitis |
Conjunctivitis |
Lymphadenopathy |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Esophagitis |
Pancreatitis |
Iridocyclitis |
Epididymitis |
Eczematoid dermatitis |
Atopic dermatitis |
Erythema nodosum |
Recurrent skin infections |
Recurrent pneumonia |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
Disease(s) Associated with TGFB1 | |||||||||||||||||||||||||||||||
asthma | |||||||||||||||||||||||||||||||
atopic dermatitis | |||||||||||||||||||||||||||||||
Behcet's disease | |||||||||||||||||||||||||||||||
cystic fibrosis | |||||||||||||||||||||||||||||||
eosinophilic esophagitis | |||||||||||||||||||||||||||||||
factor VIII deficiency | |||||||||||||||||||||||||||||||
multiple myeloma |
Mouse Phenotypes | immune system phenotype |
phlebitis |
heart inflammation |
atrial endocarditis |
myocarditis |
pericarditis |
increased T cell proliferation |
large intestinal inflammation |
cecum inflammation |
colitis |
proctitis |
small intestinal inflammation |
salivary gland inflammation |
stomach inflammation |
decreased thymus weight |
thymus hypoplasia |
lacrimal gland inflammation |
pancreas inflammation |
abnormal T cell differentiation |
abnormal T-helper 17 cell differentiation |
decreased Langerhans cell number |
absent Langerhans cell |
abnormal T cell subpopulation ratio |
increased T-helper 1 cell number |
decreased T-helper 17 cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal T cell morphology |
decreased spleen weight |
small spleen |
spleen hypoplasia |
abnormal T cell activation |
abnormal regulatory T cell physiology |
abnormal interferon level |
abnormal interleukin level |
abnormal immune system organ morphology |
abnormal Peyer's patch germinal center morphology |
decreased Peyer's patch number |
enlarged lymph nodes |
abnormal immune system physiology |
lymph node inflammation |
increased interferon-gamma secretion |
increased interleukin-2 secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
abnormal inflammatory response |
increased inflammatory response |
brain inflammation |
diaphragmitis |
eye inflammation |
conjunctivitis |
liver inflammation |
myositis |
lung inflammation |
interstitial pneumonia |
skin inflammation |
|
Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm1Doe/Tgfb1tm1Doe | ! | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm1N/Tgfb1tm1N | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm1Rif/Tgfb1tm1Rif | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv Tg(CD207-cre)1Dhka/? (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tg(Lck-cre)548Jxm/? Tgfb1tm2.1Doe/Tgfb1tm2.1Doe (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tnfrsf4tm2(cre)Nik/Tnfrsf4+ (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (conditional) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv Tg(CD207-cre)1Dhka/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/05/2024 MGI 6.24 |
|
|