Symbol
Name
ID

Vav1
vav 1 oncogene
MGI:98923

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased B cell proliferation

decreased T cell proliferation

thymus hypoplasia

decreased thymocyte number

increased DN2 thymocyte number

increased DN3 thymocyte number

increased transitional stage B cell number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal negative T cell selection

abnormal positive T cell selection

abnormal double-negative T cell morphology

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

abnormal lymphocyte cell number

abnormal B cell number

decreased mature B cell number

decreased B-1 B cell number

abnormal T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased T cell number

decreased single-positive T cell number

increased T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal splenic cell ratio

decreased IgD level

decreased IgG1 level

decreased IgG2a level

decreased IgG3 level

decreased IgG level

increased IgM level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal T cell activation

increased circulating interferon-gamma level

abnormal lymph node cell ratio

abnormal immune system physiology

abnormal humoral immune response

impaired humoral immune response

abnormal immune serum protein physiology

decreased interferon-gamma secretion

abnormal interleukin-2 secretion

decreased interleukin-2 secretion

decreased interleukin-4 secretion

decreased tumor necrosis factor secretion

abnormal response to infection

Availability

Mouse Genotype

Vav1^m1Anu/Vav1^m1Anu

Vav1^m1Btlr/Vav1^m1Btlr

Vav1^m2Btlr/Vav1^m2Btlr

Vav1^M3Btlr/Vav1^M3Btlr

Vav1^M4Btlr/Vav1^M4Btlr

Vav1^M5Btlr/Vav1^M5Btlr

Vav1^tm1Tyb/Vav1^tm1Tyb

Vav1^tm2Bbd/Vav1^tm2Bbd

Vav1^tm2Tyb/Vav1^tm2Tyb

Vav1^tm4Tyb/Vav1^tm4Tyb

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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