Symbol Name ID |
Fasl
Fas ligand MGI:99255 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal lymphocyte apoptosis |
Decreased lymphocyte apoptosis |
Increased circulating IgA concentration |
Increased circulating IgE concentration |
Decreased circulating IgG concentration |
Increased circulating IgG concentration |
Decreased circulating total IgM |
Increased circulating IgM level |
Decreased specific anti-polysaccharide antibody level |
Increased circulating antibody concentration |
Reduced delayed hypersensitivity |
Autoimmune hemolytic anemia |
Eosinophilia |
Neutropenia in presence of anti-neutropil antibodies |
Increased B cell count |
Decreased proportion of CD4-positive helper T cells |
Abnormal proportion of CD4-positive T cells |
Abnormal proportion of CD8-positive T cells |
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells |
Increased proportion of HLA DR+ T cells |
Lymphocytosis |
Lymphopenia |
Leukocytosis |
Abnormal granulocyte morphology |
Abnormal basophil morphology |
Ph-positive acute lymphoblastic leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Autoimmune thrombocytopenia |
Recurrent aphthous stomatitis |
Lymphadenopathy |
Chronic noninfectious lymphadenopathy |
Follicular hyperplasia |
Splenomegaly |
Hepatosplenomegaly |
Hypersplenism |
Colitis |
Helicobacter pylori infection |
Peritoneal abscess |
Hepatitis |
Thyroiditis |
Uveitis |
Glomerulonephritis |
Abnormal circulating interleukin concentration |
Increased circulating interleukin 10 concentration |
Increased circulating interleukin 18 concentration |
Panniculitis |
Autoimmunity |
Anti-smooth muscle antibody positivity |
Antineutrophil antibody positivity |
Antinuclear antibody positivity |
Antiphospholipid antibody positivity |
Platelet antibody positive |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Disease(s) Associated with FASLG | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
autoimmune lymphoproliferative syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
chronic myeloid leukemia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
pancreatic cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
pre-eclampsia |
Mouse Phenotypes | immune system phenotype |
increased B cell proliferation |
abnormal T cell proliferation |
increased T cell proliferation |
impaired macrophage phagocytosis |
abnormal thymus cell ratio |
enlarged thymus |
enlarged spleen |
increased spleen weight |
abnormal T cell differentiation |
abnormal double-negative T cell morphology |
increased neutrophil cell number |
decreased granulocyte number |
increased germinal center B cell number |
increased plasma cell number |
decreased B cell number |
increased T cell number |
increased lymphocyte cell number |
increased leukocyte cell number |
abnormal T cell morphology |
increased IgA level |
increased IgE level |
increased IgG1 level |
increased IgG2a level |
increased IgG2b level |
decreased IgG level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal cytotoxic T cell physiology |
decreased cytotoxic T cell cytolysis |
abnormal osteoclast physiology |
increased circulating tumor necrosis factor level |
abnormal interleukin level |
abnormal lymph node morphology |
enlarged lymph nodes |
lymphoid hyperplasia |
abnormal humoral immune response |
impaired humoral immune response |
autoimmune response |
increased susceptibility to autoimmune diabetes |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
CNS inflammation |
brain inflammation |
eye inflammation |
liver inflammation |
glomerulonephritis |
interstitial pneumonia |
dermatitis |
increased susceptibility to bacterial infection |
increased susceptibility to Picornaviridae infection |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasldel1Hong/Fasldel1Hong | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Faslgld/Faslgld | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Faslm1Btlr/Faslm1Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Faslm2Btlr/Faslm2Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasltm1.1Ast/Fasltm1.1Ast | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasltm1.1Bksa/Fasltm1.1Bksa | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasltm1.1Cgm/Fasltm1.1Cgm | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasltm1.1Lest/Fasltm1.1Lest | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fasltm2.1Ast/Fasltm2.1Ast | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tg(Ins2-Fasl)24Ach/0 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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