Symbol
Name
ID

Runx1
runt related transcription factor 1
MGI:99852

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia
Disease(s) Associated with RUNX1	Acute myeloid leukemia
acute myeloid leukemia

Mouse Phenotypes

immune system phenotype

increased thymocyte apoptosis

abnormal granulocyte differentiation

abnormal thymus lobule morphology

abnormal thymus corticomedullary boundary morphology

decreased thymus weight

small thymus

thymus hypoplasia

decreased thymocyte number

thymus cyst

enlarged spleen

increased spleen weight

abnormal leukopoiesis

abnormal B cell differentiation

decreased immature B cell number

decreased pre-pro B cell number

increased pro-B cell number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

abnormal double-positive T cell morphology

decreased double-positive T cell number

increased double-positive T cell number

arrested T cell differentiation

abnormal myelopoiesis

impaired myelopoiesis

myeloid hyperplasia

increased mast cell number

increased neutrophil cell number

increased granulocyte number

decreased mature B cell number

increased mature B cell number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

abnormal leukocyte morphology

increased spleen red pulp amount

abnormal spleen white pulp morphology

decreased spleen white pulp amount

abnormal lymph organ development

abnormal immune system organ morphology

abnormal Peyer's patch morphology

decreased Peyer's patch number

small Peyer's patches

abnormal lymph node size

abnormal axillary lymph node morphology

abnormal inguinal lymph node morphology

lung inflammation

Availability

Mouse Genotype

Runx1^tm1Itan/Runx1^tm1Itan

Runx1^tm1Spe/Runx1^tm1Spe

Runx1^tm1Yg/Runx1^tm1Yg

Runx1^tm2.1Gss/Runx1^tm2.1Gss

Runx1^tm2Itan/Runx1^tm2Itan

Runx1^tm3Itan/Runx1^tm3Itan

Runx1^tm4Spe/Runx1^tm4Spe

Runx1^tm8Spe/Runx1^tm8Spe

Runx1^tm1Spe/Runx1⁺

Runx1^tm4Spe/Runx1⁺

Runx1^tm5Spe/Runx1⁺

Runx1^tm6Spe/Runx1⁺

Runx1^tm7Spe/Runx1⁺

Runx1^tm8Spe/Runx1⁺

Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg}
Tg(Mx1-cre)1Cgn/0 (conditional)

Runx1^tm1Tani/Runx1^tm1Tani
Tg(Lck-cre)1Cwi/? (conditional)

Runx1^tm1Tani/Runx1^tm1Tani
Tg(Cd4-cre)1Cwi/? (conditional)

Runx1^tm1Yg/Runx1^tm1Yg
Tg(Lck-cre)1Jtak/? (conditional)

Runx1^tm2Buch/Runx1^tm2Buch
Tg(Mx1-cre)1Cgn/? (conditional)

Runx1^tm3Spe/Runx1^tm3Spe
Tg(Mx1-cre)1Cgn/0 (conditional)

Runx1^tm3Spe/Runx1^tm3Spe
Tg(VAV1-cre)1Graf/0 (conditional)

Runx1^tm1Soga/Runx1^tm1.1Soga
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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