Symbol Name ID |
Msh2
mutS homolog 2 MGI:101816 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Leukemia |
Hematological neoplasm |
Lymphoma |
Non-Hodgkin lymphoma |
T-cell lymphoma |
Adenoma sebaceum |
Salivary gland neoplasm |
Breast carcinoma |
Neoplasm of the rectum |
Adenocarcinoma of the colon |
Hereditary nonpolyposis colorectal carcinoma |
Adenomatous colonic polyposis |
Colon cancer |
Intestinal polyposis |
Neoplasm of the stomach |
Neoplasm of the liver |
Hepatocellular carcinoma |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Benign gastrointestinal tract tumors |
Adenocarcinoma of the small intestine |
Duodenal adenocarcinoma |
Pituitary adenoma |
Neoplasm of the thyroid gland |
Ovarian neoplasm |
Endometrial carcinoma |
Uterine leiomyosarcoma |
Renal neoplasm |
Renal cell carcinoma |
Benign genitourinary tract neoplasm |
Malignant genitourinary tract tumor |
Urinary tract neoplasm |
Bladder neoplasm |
Transitional cell carcinoma of the bladder |
Sebaceous gland carcinoma |
Neoplasm of the skin |
Basal cell carcinoma |
Plexiform neurofibroma |
Rhabdomyosarcoma |
Neoplasm of the skeletal system |
Astrocytoma |
Pleomorphic xanthoastrocytoma |
Ependymoma |
Glioblastoma multiforme |
Oligodendroglioma |
Benign neoplasm of the central nervous system |
Medulloblastoma |
Neuroblastoma |
Alveolar cell carcinoma |
Non-small cell lung carcinoma |
Lung adenocarcinoma |
Laryngeal carcinoma |
Disease(s) Associated with MSH2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
breast cancer | ||||||||||||||||||||||||||||||||||||||||||||||||||||
colorectal cancer | ||||||||||||||||||||||||||||||||||||||||||||||||||||
lung cancer | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Lynch syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Lynch syndrome 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
mismatch repair cancer syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Muir-Torre syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||
urinary bladder cancer |
Mouse Phenotypes | neoplasm |
increased gastrointestinal tumor incidence |
increased intestinal adenocarcinoma incidence |
increased small intestine adenocarcinoma incidence |
increased intestinal adenoma incidence |
increased mammary gland tumor incidence |
increased T cell derived lymphoma incidence |
increased lymphoblastic lymphoma incidence |
increased incidence of tumors by chemical induction |
increased skin tumor incidence |
increased liver tumor incidence |
increased liver adenoma incidence |
abnormal tumor morphology |
increased lymphoma incidence |
increased squamous cell carcinoma incidence |
increased hemangiosarcoma incidence |
increased osteosarcoma incidence |
increased brain tumor incidence |
increased uterus tumor incidence |
increased lung tumor incidence |
increased tumor incidence |
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Availability | Mouse Genotype | |||||||||||||||||||||
Msh2tm1Htr/Msh2tm1Htr | ||||||||||||||||||||||
Msh2tm1Mak/Msh2tm1Mak | ||||||||||||||||||||||
Msh2tm1Rak/Msh2tm1Rak | ||||||||||||||||||||||
Msh2tm1Whl/Msh2tm1Whl | ||||||||||||||||||||||
Msh2tm2.1Rak/Msh2tm2.1Rak | * | |||||||||||||||||||||
Msh2tm2.2Rak/Msh2tm2.2Rak | ||||||||||||||||||||||
Msh2tm1Htr/Msh2+ | ||||||||||||||||||||||
Msh2tm1Rak/Msh2+ | ||||||||||||||||||||||
Msh2tm2.1Rak/Msh2tm2.1Rak Tg(Vil1-cre)20Syr/0 (conditional) |
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Msh2tm1Rak/Msh2tm2.1Rak Tg(Vil1-cre)20Syr/0 (conditional) |
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Msh2tm2.1Rak/Msh2tm3.1Rak Tg(Vil1-cre)20Syr/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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