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Symbol
Name
ID

Lep
leptin
MGI:104663

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Orthostatic hypotension due to autonomic dysfunction	Pituitary hypothyroidism	Polyphagia	Addictive alcohol use
Disease(s) Associated with LEP	Orthostatic hypotension due to autonomic dysfunction	Pituitary hypothyroidism	Polyphagia	Addictive alcohol use
alcohol dependence
congenital leptin deficiency

Mouse Phenotypes

nervous system phenotype

abnormal embryonic neuroepithelium morphology

decreased embryonic neuroepithelium thickness

decreased somatotroph cell number

abnormal microglial cell physiology

abnormal cortical plate morphology

abnormal neuron morphology

abnormal sympathetic nervous system physiology

decreased embryonic neuroepithelial cell proliferation

decreased nerve conduction velocity

abnormal excitatory postsynaptic currents

abnormal inhibitory postsynaptic currents

Availability

Mouse Genotype

Lep^ob/Lep^ob

Lep^ob/Lep^ob
Tg(Npy-MAPT/Sapphire)1Rck/0

*

Lep^ob/Lep^ob
Tg(Pomc-MAPT/Topaz)1Rck/0

Lep^tm1.2Gvcao/Lep^tm1.2Gvcao

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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