|
Symbol Name ID |
Tfam
transcription factor A, mitochondrial MGI:107810 |
| Darker colors indicate more annotations |
| Human Phenotypes | Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Neurodegeneration |
Fasciculations |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Atypical behavior |
Agitation |
Cognitive impairment |
Frontotemporal dementia |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
| Disease(s) Associated with TFAM | |||||||||||||||||||||||
| amyotrophic lateral sclerosis |
| Mouse Phenotypes | decreased neuron mitochondrial DNA content |
abnormal enteric neuron morphology |
abnormal PNS glial cell morphology |
gliosis |
abnormal dopaminergic neuron morphology |
loss of dopaminergic neurons |
decreased neuron number |
neuron degeneration |
neuronal intranuclear inclusions |
absent optic nerve |
neurodegeneration |
axon degeneration |
abnormal nervous system physiology |
|
| Availability | Mouse Genotype | |||||||||||||
| Tfamtm1.1Lrsn/Tfamtm1.1Lrsn | ||||||||||||||
| Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Camk2a-cre)1Lfr/0 (conditional) |
||||||||||||||
| Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
||||||||||||||
| Cnptm1(cre)Kan/Cnp+ Tfamtm1Lrsn/Tfamtm1Lrsn (conditional) |
||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/02/2024 MGI 6.13 |
|
|
|
||
Analysis Tools