Symbol Name ID |
Tubb5
tubulin, beta 5 class I MGI:107812 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Dandy-Walker malformation |
Microcephaly |
Primary microcephaly |
Hypoplasia of the brainstem |
Dilated fourth ventricle |
Subcortical band heterotopia |
Focal polymicrogyria |
Cortical dysplasia |
Dysgenesis of the basal ganglia |
Thin corpus callosum |
Partial agenesis of the corpus callosum |
Hypoplasia of the corpus callosum |
Cerebellar vermis hypoplasia |
Cerebellar vermis atrophy |
Localized neuroblastoma |
Ataxia |
Delayed speech and language development |
Intellectual disability |
Global developmental delay |
Motor delay |
Disease(s) Associated with TUBB | ||||||||||||||||||||
complex cortical dysplasia with other brain malformations 6 | ||||||||||||||||||||
congenital symmetric circumferential skin creases 1 |
Mouse Phenotypes | nervous system phenotype |
increased neuron apoptosis |
decreased brain size |
decreased corpus callosum size |
abnormal putamen morphology |
small thalamus |
small hippocampus |
thin cerebral cortex |
small olfactory bulb |
abnormal cerebellar layer morphology |
small cerebellum |
abnormal neuron morphology |
|
Availability | Mouse Genotype | ||||||||||||
Tubb5tm1.1Dak/Tubb5tm1.1Dak Tg(Nes-cre)1Kln/0 (conditional) |
|||||||||||||
Tubb5tm2.1Dak/Tubb5tm2.1Dak Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||
Tubb5tm1.1Dak/Tubb5+ Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||
Tubb5tm2.1Dak/Tubb5+ Tg(Nes-cre)1Kln/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/05/2024 MGI 6.24 |
|
|