Symbol Name ID |
Prx
periaxin MGI:108176 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Tongue fasciculations |
Increased CSF protein concentration |
Difficulty walking |
Decreased number of peripheral myelinated nerve fibers |
Decreased number of large peripheral myelinated nerve fibers |
Onion bulb formation |
Basal lamina onion bulb formation |
Peripheral demyelination |
Segmental peripheral demyelination/remyelination |
Myelin tomacula |
Hypertrophic nerve changes |
Gait ataxia |
Vocal cord paresis |
Decreased motor nerve conduction velocity |
Decreased sensory nerve conduction velocity |
Areflexia |
Hyporeflexia |
Broad-based gait |
Loss of ambulation |
Steppage gait |
Motor delay |
Distal sensory impairment |
Impaired distal vibration sensation |
Sensory ataxia |
Disease(s) Associated with PRX | ||||||||||||||||||||||||
Charcot-Marie-Tooth disease type 3 | ||||||||||||||||||||||||
Charcot-Marie-Tooth disease type 4F |
Mouse Phenotypes | nervous system phenotype |
absent Cajal-Retzius cell |
abnormal Schwann cell morphology |
increased Schwann cell number |
abnormal internode morphology |
abnormal myelination |
abnormal nervous system electrophysiology |
abnormal action potential |
abnormal nerve conduction |
decreased nerve conduction velocity |
|
Availability | Mouse Genotype | ||||||||||
Prxtm1Brp/Prxtm1Brp | |||||||||||
Prxtm1Brp/Prxtm1Brp Tg(Mpz/GJB1-Prx*)#Brp/0 |
* | ||||||||||
Prxtm2.1Brp/Prxtm2.1Brp |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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