Symbol Name ID |
Lig3
ligase III, DNA, ATP-dependent MGI:109152 |
Darker colors indicate more annotations |
Human Phenotypes | Stroke-like episode |
Anorexia |
Dysphagia |
Thin corpus callosum |
Diffuse leukoencephalopathy |
Cerebellar atrophy |
Dysmetria |
Involuntary movements |
Myoclonus |
Abnormal pyramidal sign |
Mental deterioration |
Headache |
Disease(s) Associated with LIG3 | ||||||||||||
mitochondrial DNA depletion syndrome 20 | ||||||||||||
pancreatic cancer |
Mouse Phenotypes | abnormal neuron differentiation |
abnormal neuronal precursor proliferation |
abnormal cerebellum development |
decreased brain size |
decreased cerebellar granule cell number |
small cerebellum |
abnormal astrocyte morphology |
decreased oligodendrocyte number |
abnormal astrocyte physiology |
|
Availability | Mouse Genotype | |||||||||
Lig3tm1.1Pmc/Lig3tm1.1Pmc Tg(Nes-cre)1Kln/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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