Symbol Name ID |
Tyrobp
TYRO protein tyrosine kinase binding protein MGI:1277211 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Oculomotor apraxia |
Spasticity |
Cerebral calcification |
Basal ganglia calcification |
Gliosis |
Peripheral demyelination |
Abnormal upper motor neuron morphology |
Axonal loss |
Lateral ventricle dilatation |
Hydrocephalus |
Ventriculomegaly |
Cerebral cortical atrophy |
Caudate atrophy |
Hypoplasia of the corpus callosum |
Cerebral atrophy |
Leukoencephalopathy |
Apraxia |
Chorea |
Myoclonus |
Babinski sign |
EEG abnormality |
Euphoria |
Irritability |
Disinhibition |
Aggressive behavior |
Inappropriate behavior |
Abnormal speech pattern |
Disturbed sensory perception |
Lack of insight |
Atypical behavior |
Personality changes |
Memory impairment |
Dementia |
Frontal lobe dementia |
Abnormality of movement |
Primitive reflex |
Gait disturbance |
Developmental regression |
Seizure |
Disease(s) Associated with TYROBP | |||||||||||||||||||||||||||||||||||||||
Nasu-Hakola disease |
Mouse Phenotypes | nervous system phenotype |
abnormal microglial cell morphology |
abnormal oligodendrocyte morphology |
abnormal neuron morphology |
abnormal axon morphology |
abnormal myelination |
reduced sensorimotor gating |
abnormal excitatory postsynaptic currents |
abnormal inhibitory postsynaptic currents |
enhanced long-term potentiation |
decreased prepulse inhibition |
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Availability | Mouse Genotype | |||||||||||
Tyrobptm1.1Viv/Tyrobptm1.1Viv | * | |||||||||||
Tyrobptm1Ttk/Tyrobptm1Ttk |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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