Symbol
Name
ID

Apaf1
apoptotic peptidase activating factor 1
MGI:1306796

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

nervous system phenotype

intracerebral hemorrhage

decreased neuron apoptosis

increased neuron apoptosis

abnormal neuron differentiation

abnormal neuronal migration

abnormal neural tube morphology

abnormal embryonic neuroepithelium morphology

abnormal embryonic neuroepithelial layer differentiation

increased embryonic neuroepithelium thickness

delayed neural tube closure

open neural tube

spina bifida

spina bifida occulta

abnormal brain morphology

abnormal brain development

abnormal forebrain development

abnormal cortical marginal zone morphology

abnormal folding of telencephalic vesicles

small embryonic telencephalon

abnormal cranial flexure morphology

hydrocephaly

midbrain hyperplasia

abnormal brain ventricle morphology

abnormal fourth ventricle morphology

abnormal lateral ventricle morphology

choroid plexus hyperplasia

abnormal third ventricle morphology

abnormal forebrain morphology

abnormal hypothalamus morphology

hypothalamus hyperplasia

abnormal thalamus morphology

thalamus hyperplasia

diencephalon hyperplasia

abnormal telencephalon morphology

abnormal cerebral hemisphere morphology

thickened cerebral cortex

abnormal hindbrain morphology

abnormal embryonic/fetal subventricular zone morphology

exencephaly

abnormal neuron morphology

motor neuron degeneration

encephalomeningocele

abnormal neuron physiology

Availability

Mouse Genotype

Apaf1^fog/Apaf1^fog

Apaf1^{Gt(IRESBetageo)XIX18Pgr}/Apaf1^{Gt(IRESBetageo)XIX18Pgr}

Apaf1^tm1Her/Apaf1^tm1Her

Apaf1^tm1Mak/Apaf1^tm1Mak

Apaf1^ytj/Apaf1^ytj

Apaf1^fog/Apaf1^{Gt(IRESBetageo)XIX18Pgr}

Apaf1^fog/Apaf1^tm1Her

Apaf1^fog/Apaf1^tm1Mak

Apaf1^fog/Apaf1^ytj

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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