Symbol Name ID |
Dyrk1a
dual-specificity tyrosine phosphorylation regulated kinase 1a MGI:1330299 |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Primary microcephaly |
Secondary microcephaly |
Ventriculomegaly |
Cerebral cortical atrophy |
Thin corpus callosum |
Ataxia |
Incoordination |
Delayed speech and language development |
Happy demeanor |
Inappropriate laughter |
Autism |
Hyperactivity |
Motor stereotypy |
Tongue thrusting |
Stereotypical hand wringing |
Intellectual disability, severe |
Gait disturbance |
Global developmental delay |
Severe global developmental delay |
Seizure |
Bilateral tonic-clonic seizure |
Febrile seizure (within the age range of 3 months to 6 years) |
Disease(s) Associated with DYRK1A | |||||||||||||||||||||||
autosomal dominant intellectual developmental disorder 7 |
Mouse Phenotypes | environmentally induced seizures |
abnormal brain size |
decreased brain weight |
increased brain weight |
decreased hindbrain size |
abnormal midbrain size |
decreased midbrain size |
decreased brain size |
increased brain size |
abnormal lateral ventricle morphology |
abnormal third ventricle morphology |
decreased superior colliculus size |
small tectum |
abnormal thalamus morphology |
abnormal hippocampus morphology |
abnormal dentate gyrus morphology |
abnormal hippocampus molecular cell layer |
abnormal hippocampus stratum oriens morphology |
decreased hippocampus volume |
abnormal cerebral hemisphere morphology |
abnormal cerebral cortex pyramidal cell morphology |
abnormal premotor cortex morphology |
abnormal somatosensory cortex morphology |
abnormal nervous system development |
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Availability | Mouse Genotype | ||||||||||||||||||||||||
Dyrk1atm1Mla/Dyrk1atm1Mla | |||||||||||||||||||||||||
Dyrk1aem1Kzy/Dyrk1a+ | |||||||||||||||||||||||||
Dyrk1atm1Mla/Dyrk1a+ | |||||||||||||||||||||||||
Tg(Dyrk1a)189N3Yah/0 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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