Symbol
Name
ID

Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Spasticity

Fatigable weakness of bulbar muscles

Fatigable weakness of swallowing muscles

Fatigable weakness of respiratory muscles

Motor neuron atrophy

Amyotrophic lateral sclerosis

Neurodegeneration

Fasciculations

Paralysis

Babinski sign

Dysarthria

Language impairment

Depression

Emotional lability

Anxiety

Atypical behavior

Agitation

Cognitive impairment

Frontotemporal dementia

Sleep abnormality

Hyperreflexia

Jaw hyperreflexia

Disease(s) Associated with PPARGC1A

amyotrophic lateral sclerosis

Mouse Phenotypes

myoclonus

abnormal brainstem morphology

abnormal substantia nigra morphology

abnormal basal ganglion morphology

abnormal hippocampus morphology

abnormal cerebral cortex morphology

abnormal cerebellum morphology

gliosis

abnormal neuron morphology

decreased dopaminergic neuron number

short photoreceptor inner segment

short photoreceptor outer segment

retina photoreceptor degeneration

neurodegeneration

spongiform encephalopathy

Availability

Mouse Genotype

Ppargc1a^tm1Brsp/Ppargc1a^tm1Brsp

Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk

Ppargc1a^tm1Brsp/Ppargc1a⁺

Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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