Symbol Name ID |
Fbxw7
F-box and WD-40 domain protein 7 MGI:1354695 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Abnormal brain morphology |
Ataxia |
Delayed speech and language development |
Intellectual disability |
Developmental regression |
Global developmental delay |
Specific learning disability |
Seizure |
Disease(s) Associated with FBXW7 | |||||||||
developmental delay, hypotonia, and impaired language |
Mouse Phenotypes | nervous system phenotype |
abnormal brain vasculature morphology |
intracranial hemorrhage |
abnormal neuron differentiation |
abnormal neural tube closure |
open neural tube |
abnormal brain development |
abnormal cortical intermediate zone morphology |
abnormal cortical plate morphology |
abnormal cerebellum development |
abnormal cerebellar foliation |
abnormal tectum morphology |
thalamus hypoplasia |
abnormal cerebral cortex morphology |
abnormal Purkinje cell morphology |
decreased Purkinje cell number |
decreased Purkinje cell size |
abnormal cerebellum fissure morphology |
cerebellum vermis hypoplasia |
small cerebellum |
abnormal embryonic/fetal subventricular zone morphology |
decreased neuronal precursor cell number |
|
Availability | Mouse Genotype | ||||||||||||||||||||||
Fbxw7tm1Kin/Fbxw7tm1Kin | |||||||||||||||||||||||
Fbxw7tm1Sje/Fbxw7tm1Sje | |||||||||||||||||||||||
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||||||||||||
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj/0 (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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