Symbol Name ID |
Prkn
parkin RBR E3 ubiquitin protein ligase MGI:1355296 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Substantia nigra gliosis |
Cerebral atrophy |
Lewy bodies |
Gait ataxia |
Bradykinesia |
Parkinsonism |
Tremor |
Postural tremor |
Resting tremor |
Pill-rolling tremor |
Babinski sign |
Dementia |
Hyperreflexia |
Hypokinesia |
Dystonia |
Focal dystonia |
Gait disturbance |
Loss of ambulation |
Shuffling gait |
Postural instability |
Disease(s) Associated with PRKN | ||||||||||||||||||||
Parkinson's disease 2 |
Mouse Phenotypes | nervous system phenotype |
increased neuron apoptosis |
abnormal substantia nigra pars compacta morphology |
decreased substantia nigra size |
abnormal locus ceruleus morphology |
hippocampal neuron degeneration |
brain vacuoles |
tau protein deposits |
abnormal CNS glial cell morphology |
abnormal neuron morphology |
decreased dopaminergic neuron number |
loss of dopaminergic neurons |
neuron degeneration |
abnormal nervous system electrophysiology |
abnormal synaptic transmission |
|
Availability | Mouse Genotype | |||||||||||||||
Prkntm1Ccs/Prkntm1Ccs | * | |||||||||||||||
Prkntm1Roo/Prkntm1Roo | * | |||||||||||||||
Prkntm1Rpa/Prkntm1Rpa | * | |||||||||||||||
Prkntm1Shn/Prkntm1Shn | ||||||||||||||||
Prkntm1Tmd/Prkntm1Tmd | ||||||||||||||||
Prkntm1Ykt/Prkntm1Ykt | ||||||||||||||||
Prkntm2Tmd/Prkntm2Tmd (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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