Symbol Name ID |
Spast
spastin MGI:1858896 |
Darker colors indicate more annotations |
Human Phenotypes | Ankle clonus |
Spasticity |
Lower limb spasticity |
Spastic paraplegia |
Spastic gait |
Degeneration of the lateral corticospinal tracts |
Ataxia |
Babinski sign |
Paraplegia |
Depression |
Apathy |
Agitation |
Disinhibition |
Aggressive behavior |
Dysarthria |
Cognitive impairment |
Memory impairment |
Dementia |
Intellectual disability |
Hyperreflexia |
Brisk reflexes |
Hyperreflexia in upper limbs |
Seizure |
Impaired vibration sensation at ankles |
Impaired vibration sensation in the lower limbs |
Disease(s) Associated with SPAST | |||||||||||||||||||||||||
hereditary spastic paraplegia 4 |
Mouse Phenotypes | abnormal brain morphology |
hydrocephaly |
abnormal axon morphology |
abnormal axonal transport |
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Availability | Mouse Genotype | ||||
SpastM1Gri/SpastM1Gri | |||||
Spasttm1.1Evre/Spasttm1.1Evre | |||||
Spasttm1.1Jme/Spasttm1.1Jme | |||||
Spasttm1b(KOMP)Wtsi/Spasttm1b(KOMP)Wtsi | |||||
SpastM1Gri/Spast+ | |||||
Spasttm1.1Jme/Spast+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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