Symbol Name ID |
Wdr45
WD repeat domain 45 MGI:1859606 |
Darker colors indicate more annotations |
Human Phenotypes | Spastic paraparesis |
Eye of the tiger anomaly of globus pallidus |
Iron accumulation in substantia nigra |
Cerebral atrophy |
Cerebellar atrophy |
Iron accumulation in brain |
Neurodegeneration |
Bradykinesia |
Parkinsonism |
Tremor |
Absent speech |
Delayed speech and language development |
Poor speech |
Anxiety |
Aggressive behavior |
Mental deterioration |
Dementia |
Intellectual disability |
Sleep abnormality |
Abnormal postural reflex |
Akinesia |
Dystonia |
Frontal release signs |
Progressive encephalopathy |
Global developmental delay |
Delayed ability to walk |
Seizure |
Abnormal autonomic nervous system physiology |
Disease(s) Associated with WDR45 | ||||||||||||||||||||||||||||
neurodegeneration with brain iron accumulation 5 |
Mouse Phenotypes | abnormal cerebellar Purkinje cell layer |
brain vacuoles |
astrocytosis |
decreased dopaminergic neuron number |
neurodegeneration |
axon degeneration |
axonal spheroids |
demyelination |
abnormal excitatory postsynaptic potential |
reduced long-term potentiation |
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Availability | Mouse Genotype | ||||||||||
Wdr45em1Wrst/Wdr45em1Wrst | |||||||||||
Wdr45em1Wrst/Y | |||||||||||
Wdr45tm1Beij/Wdr45tm1Beij Tg(Nes-cre)1Kln/0 (conditional) |
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Wdr45tm1Beij/Wdr45+ Tg(Nes-cre)1Kln/0 (conditional) |
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Wdr45tm1Beij/Y Tg(Nes-cre)1Kln/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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