Symbol
Name
ID

Mfn2
mitofusin 2
MGI:2442230

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Areflexia of lower limbs

Absent patellar reflexes

Absent Achilles reflex

Frequent falls

Sensory axonal neuropathy

Hydrocephalus

Abnormal spinal cord morphology

Poor fine motor coordination

Postural tremor

Hand tremor

Vocal cord paralysis

Babinski sign

Restless legs

Inability to walk by childhood/adolescence

Steppage gait

Somatic sensory dysfunction

Impaired pain sensation

Impaired temperature sensation

Paresthesia

Distal sensory impairment

Impaired vibratory sensation

Disease(s) Associated with MFN2

Charcot-Marie-Tooth disease type 2A2A

Mouse Phenotypes

abnormal neuron mitochondrial morphology

increased neuron apoptosis

abnormal substantia nigra pars compacta morphology

abnormal cerebellum morphology

Purkinje cell degeneration

abnormal Purkinje cell dendrite morphology

small cerebellum

abnormal innervation

abnormal motor neuron morphology

abnormal axon morphology

abnormal neuron physiology

abnormal axonal transport

Availability

Mouse Genotype

Mfn2^tm1.1Balo/Mfn2^tm1.1Balo

Mfn2^tm2Dcc/Mfn2^tm2Dcc

Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc

Mfn2^tm1.1Arte/Mfn2^tm1.1Arte
Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ (conditional)

En1^tm2(cre)Wrst/En1⁺
Mfn2^tm1Dcc/Mfn2^tm3Dcc (conditional)

Mfn2^tm1Dcc/Mfn2^tm3Dcc
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Meox2^tm1(cre)Sor/Meox2⁺
Mfn2^tm1Dcc/Mfn2^tm3Dcc (conditional)

Mfn2^tm1Dcc/Mfn2^tm3Dcc
Tg(Pcp2-cre)2Mpin/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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