Symbol Name ID |
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat) MGI:3039785 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Torticollis |
Brain atrophy |
EEG abnormality |
Language impairment |
Autistic behavior |
Intellectual disability |
Intellectual disability, moderate |
Epileptic encephalopathy |
Developmental regression |
Global developmental delay |
Motor delay |
Seizure |
Bilateral tonic-clonic seizure |
Myoclonic absence seizure |
Disease(s) Associated with SYNGAP1 | |||||||||||||||
autosomal dominant intellectual developmental disorder 5 |
Mouse Phenotypes | nervous system phenotype |
increased susceptibility to pharmacologically induced seizures |
audiogenic seizures |
increased neuron apoptosis |
decreased brain size |
abnormal hippocampus pyramidal cell morphology |
abnormal neuron morphology |
abnormal dendrite morphology |
abnormal dendritic spine morphology |
impaired synaptic plasticity |
abnormal CNS synaptic transmission |
abnormal excitatory postsynaptic potential |
abnormal glutamate-mediated receptor currents |
enhanced AMPA-mediated synaptic currents |
reduced long-term potentiation |
abnormal miniature excitatory postsynaptic currents |
increased miniature excitatory postsynaptic current amplitude |
increased miniature excitatory postsynaptic current frequency |
abnormal miniature inhibitory postsynaptic currents |
increased miniature inhibitory postsynaptic current amplitude |
increased miniature inhibitory postsynaptic current frequency |
decreased prepulse inhibition |
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Availability | Mouse Genotype | ||||||||||||||||||||||
Syngap1tm1.1Mabk/Syngap1tm1.1Mabk | |||||||||||||||||||||||
Syngap1tm1Rlh/Syngap1tm1Rlh | |||||||||||||||||||||||
Syngap1tm1Grnt/Syngap1+ | |||||||||||||||||||||||
Syngap1tm1Rlh/Syngap1+ | * | ||||||||||||||||||||||
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk Tg(Camk2a-cre)2834Lusc/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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