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Symbol
Name
ID 		Fgfr1
fibroblast growth factor receptor 1
MGI:95522
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Posterior fossa cyst
Abnormality of the sense of smell
Anosmia
Hyposmia
Hydrocephalus
Ventriculomegaly
Agenesis of corpus callosum
Absent septum pellucidum
Megalencephaly
Abnormal morphology of the limbic system
Aplasia of the olfactory bulb
Cerebellar hypoplasia
Chiari malformation
Chiari type I malformation
Arachnoid cyst
Delayed speech and language development
Intellectual disability
Bimanual synkinesia
Disease(s) Associated with FGFR1
acrocephalosyndactylia
hypogonadotropic hypogonadism 2 with or without anosmia
hypogonadotropic hypogonadism 7 with or without anosmia
osteoglophonic dysplasia
Pfeiffer syndrome

Mouse Phenotypes
abnormal axon guidance
abnormal neuronal migration
abnormal neural plate morphology
abnormal neural tube morphology
abnormal neural crest cell morphology
abnormal neural tube closure
spina bifida
craniorachischisis
kinked neural tube
abnormal cochlear hair cell development
abnormal cochlear hair cell morphology
decreased cochlear hair cell number
decreased cochlear outer hair cell number
absent cochlear outer hair cells
increased cochlear inner hair cell number
abnormal orientation of inner hair cell stereociliary bundles
abnormal cochlear nerve compound action potential
abnormal brain morphology
abnormal cerebellum development
abnormal brain commissure morphology
abnormal dorsal telencephalic commissure morphology
abnormal corpus callosum morphology
abnormal hippocampal commissure morphology
abnormal midbrain morphology
absent inferior colliculus
decreased inferior colliculus size
abnormal locus ceruleus morphology
abnormal frontal lobe morphology
abnormal cerebellum morphology
abnormal cerebellum vermis morphology
absent cerebellum vermis
abnormal astrocyte morphology
abnormal neuron morphology
abnormal motor neuron morphology
decreased neuron number
abnormal trochlear nerve morphology
abnormal hypothalamus secretion
Availability Mouse Genotype
Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Fgfr1tm1Cxd/Fgfr1tm1Cxd
Fgfr1tm1Jrt/Fgfr1tm1Jrt
Fgfr1tm1Led/Fgfr1tm1Led
Fgfr1tm2Jrt/Fgfr1tm2Jrt
Fgfr1tm3.1Sor/Fgfr1tm3.1Sor
Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Fgfr1tm6Jrt/Fgfr1tm6Jrt
Tg(Gnrh1-Fgfr1)1Tsai/Tg(Gnrh1-Fgfr1)1Tsai
Fgfr1Hspy/Fgfr1+
En1tm2(cre)Wrst/En1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa  (conditional)
Fgfr1tm1Jpa/Fgfr1tm1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(GFAP-cre)25Mes/0  (conditional)
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(Nes-cre)1Kln/0  (conditional)
Fgfr1tm1Upir/Fgfr1tm1Upir
Tg(Mnx1-GFP)1Slp/?
Tg(Nes-cre)1Kln/?  (conditional)
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0  (conditional)
Fgfr1tm1Upir/Fgfr1tm1.1Upir
Foxg1tm1(cre)Skm/Foxg1+  (conditional)
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory