Symbol Name ID |
Gli2
GLI-Kruppel family member GLI2 MGI:95728 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Decreased response to growth hormone stimulation test |
Ectopic posterior pituitary |
Anterior pituitary agenesis |
Anterior pituitary hypoplasia |
Hypopituitarism |
Panhypopituitarism |
Optic nerve hypoplasia |
Hydrocephalus |
Lateral ventricular asymmetry |
Abnormal cortical gyration |
Thin corpus callosum |
Partial agenesis of the corpus callosum |
Holoprosencephaly |
Alobar holoprosencephaly |
Occipital meningocele |
Intellectual disability, severe |
Global developmental delay |
Seizure |
Disease(s) Associated with GLI2 | |||||||||||||||||||
Culler-Jones syndrome | |||||||||||||||||||
holoprosencephaly 9 |
Mouse Phenotypes | nervous system phenotype |
abnormal neuron differentiation |
abnormal neural tube morphology |
abnormal floor plate morphology |
absent floor plate |
abnormal cerebellar foliation |
abnormal cerebellar lobule formation |
reduced cerebellar foliation |
abnormal cerebellum external granule cell layer morphology |
thin external granule cell layer |
hydrocephaly |
abnormal cerebellar Purkinje cell layer |
abnormal cerebellar granule layer morphology |
abnormal cerebellar molecular layer |
abnormal cerebellum anterior vermis morphology |
abnormal cerebellum vermis morphology |
small cerebellum |
abnormal motor neuron morphology |
abnormal ventral interneuron 3 morphology |
abnormal spinal cord morphology |
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Availability | Mouse Genotype | ||||||||||||||||||||
Gli2tm1Alj/Gli2tm1Alj | |||||||||||||||||||||
Gli2tm2.1Alj/Gli2tm2.1Alj | |||||||||||||||||||||
Gli2tm6.1Alj/Gli2tm6.1Alj | |||||||||||||||||||||
Gli2tm1Alj/Gli2+ | |||||||||||||||||||||
Gli2tm1Alj/Gli2tm2.1Alj | |||||||||||||||||||||
Gli2tm1Alj/Gli2tm6.1Alj | |||||||||||||||||||||
En1tm2(cre)Gld/En1+ Gli2tm1Alj/Gli2tm6Alj (conditional) |
* | ||||||||||||||||||||
Gli2tm1Alj/Gli2tm6Alj Tg(Nes-cre)1Kln/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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