|
Symbol Name ID |
Nf2
neurofibromin 2 MGI:97307 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Facial palsy |
Dysphagia |
Vestibular schwannoma |
Bilateral vestibular schwannoma |
Peripheral schwannoma |
Astrocytoma |
Glioma |
Ependymoma |
Neuroma |
Brain stem compression |
Hydrocephalus |
Abnormal cerebellum morphology |
Meningioma |
Intracranial meningioma |
Spinal meningioma |
Myelopathy |
Spinal cord tumor |
Hemiparesis |
Cranial nerve paralysis |
Aphasia |
Dysarthria |
Memory impairment |
Unsteady gait |
Postural instability |
Mononeuropathy |
Polyneuropathy |
Sensory neuropathy |
Seizure |
Somatic sensory dysfunction |
Hyperesthesia |
| Disease(s) Associated with NF2 | ||||||||||||||||||||||||||||||
| vestibular schwannomatosis |
| Mouse Phenotypes | nervous system phenotype |
increased pituitary adenoma incidence |
increased neurofibroma incidence |
increased neurofibrosarcoma incidence |
increased Schwannoma incidence |
increased meningioma incidence |
abnormal Schwann cell morphology |
increased Schwann cell number |
abnormal axon morphology |
enlarged dorsal root ganglion |
abnormal spinal nerve morphology |
abnormal action potential |
|
| Availability | Mouse Genotype | ||||||||||||
| Nf2tm1Gvn/Nf2tm1Gvn | |||||||||||||
| Nf2tm2Gvn/Nf2tm2Gvn | |||||||||||||
| Nf2tm1Gth/Nf2+ | * | ||||||||||||
| Nf2tm2.1Gth/Nf2+ | * | ||||||||||||
| Nf2tm2Gvn/Nf2+ | |||||||||||||
| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)1Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)2Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)3Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)4Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Mpz-cre)#Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth (conditional) | |||||||||||||
| Nf2tm2Gth/Nf2tm2Gth Ptgdstm1.1(cre)Gvn/Ptgds+ (conditional) |
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| Nf2tm2Gth/Nf2tm2Gth Tg(Postn-cre)1Sjc/0 (conditional) |
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| Nf2tm1Gth/Nf2tm2Gth Tg(Mpz-cre)1Brn/0 (conditional) |
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| Nf2tm1Gth/Nf2tm2Gth Tg(Mpz-cre)#Brn/0 (conditional) |
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| Nf2tm2Gth/Nf2+ Tg(Mpz-cre)#Brn/0 (conditional) |
* | ||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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