Symbol Name ID |
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2 MGI:1354953 |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Proteinuria |
Minimal change glomerulonephritis |
Steroid-resistant nephrotic syndrome |
Stage 5 chronic kidney disease |
Disease(s) Associated with MAGI2 | ||||
nephrotic syndrome type 15 |
Mouse Phenotypes | absent glomerular endothelium fenestra |
increased urine protein level |
albuminuria |
tubulointerstitial nephritis |
abnormal glomerular capsule parietal layer morphology |
abnormal podocyte morphology |
abnormal podocyte foot process morphology |
fused podocyte foot processes |
podocyte foot process effacement |
abnormal podocyte slit diaphragm morphology |
absent podocytes |
podocyte hypertrophy |
podocyte microvillus transformation |
expanded mesangial matrix |
cortical renal glomerulopathies |
glomerulosclerosis |
glomerular crescent |
renal interstitial fibrosis |
renal tubule atrophy |
renal cast |
abnormal glomerular filtration barrier function |
kidney failure |
anuria |
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Availability | Mouse Genotype | |||||||||||||||||||||||
Magi2tm1.1Knis/Magi2tm1.1Knis | ||||||||||||||||||||||||
Magi2tm1Key/Magi2tm1Key | ! |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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