Symbol
Name
ID

Gnas
GNAS complex locus
MGI:95777

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Low urinary cyclic AMP response to PTH administration
Disease(s) Associated with GNAS	Low urinary cyclic AMP response to PTH administration
Albright's hereditary osteodystrophy
pseudohypoparathyroidism
pseudohypoparathyroidism type IB

Mouse Phenotypes

increased urine dopamine level

decreased urine noradrenaline level

increased urine noradrenaline level

abnormal urine catecholamine level

abnormal urine homeostasis

decreased urine osmolality

increased urine prostaglandin level

abnormal kidney morphology

delayed kidney development

abnormal kidney physiology

decreased renal glomerular filtration rate

Availability

Mouse Genotype

Gnas^tm1Lsw/Gnas⁺

Gnas^tm4Lsw/Gnas⁺

Gnas^tm3Lsw/Gnas^tm3Lsw
Ren1^tm2(cre)Gom/Ren1⁺ (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
Tg(Slc5a2-cre)1Tauc/0 (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
Tg(Fabp4-cre)1Abel/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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