Symbol Name ID |
Nr0b1
nuclear receptor subfamily 0, group B, member 1 MGI:1352460 |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Hypogonadotropic hypogonadism |
Cryptorchidism |
Sex reversal |
Azoospermia |
Oligozoospermia |
Disease(s) Associated with NR0B1 | |||||
46,XY sex reversal 2 | |||||
X-linked adrenal hypoplasia congenita |
Mouse Phenotypes | decreased male germ cell number |
absent germ cells |
increased Sertoli cell proliferation |
polyovular ovarian follicle |
abnormal testis morphology |
rete testis obstruction |
abnormal peritubular myoid cell morphology |
decreased number of peritubular myoid cells |
abnormal seminiferous tubule epithelium morphology |
ectopic Sertoli cells |
dilated seminiferous tubule |
seminiferous tubule degeneration |
abnormal Sertoli cell development |
abnormal testis cord formation |
disorganized testis cords |
abnormal Leydig cell morphology |
abnormal fetal Leydig cell differentiation |
ectopic Leydig cells |
increased Leydig cell number |
decreased testis weight |
small testis |
increased testis tumor incidence |
abnormal reproductive system morphology |
abnormal spermatogenesis |
abnormal efferent ductules of testis morphology |
ovotestis |
abnormal primary sex determination |
primary sex reversal |
male infertility |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||
Nr0b1tm1.1Lja/Nr0b1tm1.1Lja | ||||||||||||||||||||||||||||||
Nr0b1em2(IMPC)Wtsi/Y | ||||||||||||||||||||||||||||||
Nr0b1tm1.1Lja/Y | ||||||||||||||||||||||||||||||
Nr0b1tm1Lja/Y | ! | ! | ! |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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