Symbol
Name
ID

Nkx2-1
NK2 homeobox 1
MGI:108067

Phenotype annotations related to respiratory system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal lung vasculature morphology

abnormal pulmonary circulation

abnormal mesenchymal cell differentiation involved in lung development

tracheoesophageal fistula

abnormal lung morphology

abnormal lung development

abnormal branching involved in lung morphogenesis

impaired branching involved in bronchus morphogenesis

impaired branching involved in respiratory bronchiole morphogenesis

abnormal lung saccule morphology

abnormal lung epithelium morphology

abnormal bronchus epithelium morphology

abnormal pulmonary alveolus epithelial cell morphology

abnormal type II pneumocyte morphology

absent type II pneumocytes

decreased lung weight

pulmonary hypoplasia

abnormal pulmonary acinus morphology

abnormal pulmonary alveolar parenchyma morphology

abnormal bronchus morphology

dilated respiratory conducting tube

abnormal pleural cavity morphology

abnormal trachea morphology

abnormal tracheal cartilage morphology

decreased tracheal cartilage ring number

respiratory failure

decreased surfactant secretion

Availability

Mouse Genotype

Nkx2-1^tm1Jaw/Nkx2-1^tm1Jaw

Nkx2-1^tm1Shk/Nkx2-1^tm1Shk

Nkx2-1^tm2Rdl/Nkx2-1^tm2Rdl

Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl

Nkx2-1^tm1Shk/Nkx2-1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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