Symbol Name ID |
Lrp6
low density lipoprotein receptor-related protein 6 MGI:1298218 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Aplasia of the maxilla |
Enamel hypoplasia |
Disease(s) Associated with LRP6 | ||
tooth agenesis |
Mouse Phenotypes | skeleton phenotype |
abnormal cranium morphology |
small cranium |
abnormal frontal bone morphology |
thin neurocranium |
small lower incisors |
long upper incisors |
short incisors |
abnormal molar cusp morphology |
decreased molar number |
small molars |
abnormal tooth development |
abnormal tooth eruption |
growth retardation of molars |
spina bifida occulta |
abnormal caudal vertebrae morphology |
caudal vertebral fusion |
small caudal vertebrae |
rib fusion |
abnormal vertebrae morphology |
abnormal lumbar vertebrae morphology |
abnormal sacral vertebrae morphology |
abnormal vertebrae development |
abnormal vertebral arch morphology |
absent vertebrae |
hemivertebra |
vertebral fusion |
decreased bone mineral density |
osteoporosis |
delayed cranial suture closure |
delayed bone ossification |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
Lrp6Cd/Lrp6Cd | ||||||||||||||||||||||||||||||||
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg | ||||||||||||||||||||||||||||||||
Lrp6rs/Lrp6rs | ||||||||||||||||||||||||||||||||
Lrp6Cd/Lrp6+ | ||||||||||||||||||||||||||||||||
Lrp6Cd/Lrp6Gt(Ex187)Byg | ||||||||||||||||||||||||||||||||
Lrp6Gt(Ex187)Byg/Lrp6+ | ||||||||||||||||||||||||||||||||
Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ (conditional) |
* | |||||||||||||||||||||||||||||||
Lrp6tm1.1Vari/Lrp6tm1.2Vari Twist2tm1(cre)Dor/Twist2+ (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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