Symbol Name ID |
Comp
cartilage oligomeric matrix protein MGI:88469 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Genu valgum |
Genu varum |
Short distal phalanx of finger |
Small epiphyses of the phalanges of the hand |
Short phalanx of finger |
Finger joint hypermobility |
Brachydactyly |
Avascular necrosis of the capital femoral epiphysis |
Flared femoral metaphysis |
Broad femoral neck |
Coxa vara |
Short femoral neck |
Radial metaphyseal irregularity |
Ulnar metaphyseal irregularity |
Metaphyseal irregularity |
Metaphyseal widening |
Short metacarpal |
Carpal bone hypoplasia |
Abnormal acetabulum morphology |
Genu recurvatum |
Knee joint hypermobility |
Irregular carpal bones |
Limited elbow extension |
Ulnar deviation of the wrist |
Limited shoulder movement |
Joint hypermobility |
Generalized joint hypermobility |
Limitation of joint mobility |
Joint stiffness |
Limited hip movement |
Limited hip extension |
Ankle pain |
Knee pain |
Hand pain |
Delayed epiphyseal ossification |
Epiphyseal dysplasia |
Fragmented epiphyses |
Fragmented, irregular epiphyses |
Irregular epiphyses |
Small epiphyses |
Short long bone |
Arthralgia of the hip |
Hip dysplasia |
Spatulate ribs |
Lumbar hyperlordosis |
Kyphosis |
Scoliosis |
Hypoplasia of the odontoid process |
Irregular vertebral endplates |
Beaking of vertebral bodies |
Ovoid vertebral bodies |
Platyspondyly |
Atlantoaxial dislocation |
Osteoarthritis |
Hip osteoarthritis |
Disease(s) Associated with COMP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
carpal tunnel syndrome 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
multiple epiphyseal dysplasia 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
pseudoachondroplasia |
Mouse Phenotypes | skeleton phenotype |
increased chondrocyte apoptosis |
decreased chondrocyte proliferation |
osteoarthritis |
abnormal hip joint morphology |
short femur |
short tibia |
abnormal tendon morphology |
decreased tendon stiffness |
abnormal long bone epiphyseal plate morphology |
abnormal long bone epiphyseal plate proliferative zone |
abnormal pelvic girdle bone morphology |
abnormal ischium morphology |
abnormal cartilage morphology |
abnormal chondrocyte morphology |
abnormal chondrocyte physiology |
|
Availability | Mouse Genotype | ||||||||||||||||
Comptm1Mbri/Comptm1Mbri | |||||||||||||||||
Comptm2.1Mbri/Comptm2.1Mbri | * | ||||||||||||||||
Comptm1Mbri/Comp+ | |||||||||||||||||
Comptm2.1Mbri/Comp+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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