Symbol Name ID |
Smad4
SMAD family member 4 MGI:894293 |
Darker colors indicate more annotations |
Human Phenotypes | Clubbing |
Flexion contracture |
Back pain |
Neoplasm of the skeletal system |
Disease(s) Associated with SMAD4 | ||||
hereditary hemorrhagic telangiectasia | ||||
juvenile polyposis syndrome | ||||
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome | ||||
Lynch syndrome | ||||
pancreatic cancer |
Mouse Phenotypes | abnormal osteoblast physiology |
abnormal tooth morphology |
small incisors |
abnormal enamel morphology |
malocclusion |
decreased osteoclast cell number |
abnormal tibia morphology |
decreased diameter of tibia |
short tibia |
clavicle hypoplasia |
abnormal long bone diaphysis morphology |
rib fractures |
abnormal bone collagen fibril morphology |
decreased bone mineral density |
abnormal compact bone lamellar structure |
decreased compact bone thickness |
increased compact bone thickness |
abnormal osteocyte morphology |
abnormal trabecular bone morphology |
delayed bone ossification |
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Availability | Mouse Genotype | ||||||||||||||||||||
Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional) |
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Smad4tm2.1Cxd/Smad4+ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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