Symbol Name ID |
Irs1
insulin receptor substrate 1 MGI:99454 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Osteoporosis |
Gout |
Disease(s) Associated with IRS1 | ||
coronary artery disease |
Mouse Phenotypes | skeleton phenotype |
impaired osteoblast differentiation |
abnormal osteoclast differentiation |
decreased osteoblast proliferation |
abnormal osteoblast physiology |
increased osteoclast cell number |
abnormal osteoclast physiology |
abnormal bone healing |
abnormal femur morphology |
short femur |
short tibia |
abnormal long bone epiphyseal plate proliferative zone |
abnormal long bone hypertrophic chondrocyte zone |
decreased long bone epiphyseal plate size |
abnormal bone structure |
decreased bone mineral content |
decreased bone mineral density of femur |
decreased bone mineral density |
decreased compact bone thickness |
decreased osteoblast cell number |
increased osteoblast cell number |
abnormal trabecular bone morphology |
decreased trabecular bone thickness |
decreased chondrocyte number |
abnormal bone mineralization |
|
Availability | Mouse Genotype | |||||||||||||||||||||||||
Irs1mpc178H/Irs1mpc178H | ||||||||||||||||||||||||||
Irs1Sml/Irs1Sml | ||||||||||||||||||||||||||
Irs1tm1Jos/Irs1tm1Jos | * | |||||||||||||||||||||||||
Irs1tm1Tka/Irs1tm1Tka | ||||||||||||||||||||||||||
Irs1Sml/Irs1+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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