Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Micrognathia

Clinodactyly of the 5th finger

Brachydactyly

Abnormal metaphysis morphology

Radioulnar synostosis

Joint hypermobility

Delayed skeletal maturation

Avascular necrosis

Bone pain

Abnormal epiphysis morphology

Enlarged thorax

Pectus carinatum

Pectus excavatum

Scoliosis

Osteopenia

Multiple enchondromatosis

Exostoses

Disease(s) Associated with PTPN11

metachondromatosis

Noonan syndrome

Mouse Phenotypes

skeleton phenotype

abnormal cranium size

decreased cranium height

decreased cranium length

small cranium

abnormal mandible morphology

absent mandible

micrognathia

abnormal nasal bone morphology

absent craniofacial bones

absent nasal capsule

abnormal nasal cartilage morphology

short femur

abnormal vertebral column morphology

abnormal spine curvature

kyphosis

kyphoscoliosis

lordosis

scoliosis

abnormal vertebral epiphyseal plate morphology

exostosis

ectopic cartilage

Availability

Mouse Genotype

Ptpn11^tm7Bgn/Ptpn11^tm7Bgn

Ptpn11^tm1.1Ics/Ptpn11⁺

Ptpn11^tm1Bgn/Ptpn11⁺

Ptpn11^tm4.2Bgn/Ptpn11⁺

Ptpn11^tm7Bgn/Ptpn11⁺

Ptpn11^tm1.1Rbns/Ptpn11^tm1.1Rbns
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Col2a1-cre/ERT2)1Dic/0 (conditional)

Ptpn11^tm6Bgn/Ptpn11⁺
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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