Symbol Name ID |
Trp53
transformation related protein 53 MGI:98834 |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Central retinal vessel vascular tortuosity |
Optic atrophy |
Papilledema |
Leber optic atrophy |
Optic neuropathy |
Retinoblastoma |
Proptosis |
Myopia |
Centrocecal scotoma |
Visual loss |
Open angle glaucoma |
Disease(s) Associated with TP53 | |||||||||||
choroid plexus papilloma | |||||||||||
Graves' disease | |||||||||||
Leber hereditary optic neuropathy | |||||||||||
osteosarcoma | |||||||||||
primary open angle glaucoma |
Mouse Phenotypes | abnormal retina vasculature morphology |
abnormal optic nerve morphology |
absent optic nerve |
optic nerve degeneration |
optic nerve hypoplasia |
retina coloboma |
persistence of hyaloid vascular system |
abnormal posterior eye segment morphology |
abnormal ocular fundus morphology |
abnormal retina morphology |
retina fold |
increased opacity of vitreous body |
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Availability | Mouse Genotype | ||||||||||||
Trp53tm1.2Awbr/Trp53tm1.2Awbr | |||||||||||||
Trp53tm1b(EUCOMM)Hmgu/Trp53tm1b(EUCOMM)Hmgu | |||||||||||||
Trp53tm1Tyj/Trp53tm1Tyj | ! | ! | ! | ! | ! | ! | ! | ! | |||||
Tg(CMV-cre)1Cgn/0 Trp53tm4Att/Trp53+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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