MGI Alleles and Phenotypes

The Phenotypes, Alleles & Disease Models project in MGI enables comparative phenotype analysis, searches for human disease models, and hypothesis generation by providing access to spontaneous, induced, and genetically engineered mutations and their strain-specific phenotypes.

This track data is updated weekly every Monday

Alleles

A primary objective for MGI is the maintenance of a complete catalog of phenotypic mutations in the laboratory mouse. These include spontaneous, induced, and genetically engineered mutations (targeted knockouts and conditionals, transgenics, Cre-constructs, targeted reporters, gene traps, transposon-induced mutations, etc.).

MGI serves as the international authoritative source for nomenclature for mouse alleles, and maintains a complete list of allele symbols, names, and synonyms, each with a unique accession ID. Researchers are encouraged to submit new alleles to reserve symbols and obtain accession IDs prior to publication.

A complete listing of alleles can be downloaded from the ftp site (http://www.informatics.jax.org/downloads/reports/index.html#pheno).

Credits

All data and analysis is provided by MGI. This information is also available on informatics.jax.org or for a complete data download please see http://www.informatics.jax.org/downloads/reports/index.html.

Hub data is maintained by Paul Hale (Paul.Hale@jax.org). Please email with any questions over this hub or the data herein.

Reference

Blake JA, Eppig JT, Kadin JA, Richardson JE, Smith CL, Bult CJ, and the Mouse Genome Database Group. 2017. Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse. Nucl. Acids Res. 2017 Jan. 4;45 (D1): D723-D729. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210536/