format-version: 1.2
data-version: releases/2025-02-18/mp.obo
subsetdef: CvDC_Terms ""
subsetdef: Europhenome_Terms "Terms in use by Europhenome"
subsetdef: IMPC "Terms in use by IMPC"
subsetdef: IMPC_Prenatal "Terms in use by IMPC Early Viability Group"
subsetdef: Sanger_Terms "Terms in use by Mouse Genetics Project, Sanger Institute, Wellcome Trust Genome Campus"
default-namespace: MPheno.ontology
idspace: dc http://purl.org/dc/elements/1.1/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
idspace: terms http://purl.org/dc/terms/ 
idspace: terms1 http://www.geneontology.org/formats/oboInOwl#http://purl.org/dc/terms/ 
remark: The Mammalian Phenotype Ontology Copyright © 2007, 2008, 2011, 2012, 2015, 2024 by The Jackson Laboratory.
ontology: mp
property_value: dc:contributor "Alicia Valenzuela" xsd:string
property_value: dc:contributor "Anna Anagnostopolous" xsd:string
property_value: dc:contributor "Christopher Mungall" xsd:string
property_value: dc:contributor "Eisuke Dohi" xsd:string
property_value: dc:contributor "Georgios V. Gkoutos" xsd:string
property_value: dc:contributor "Hiroshi Masuya" xsd:string
property_value: dc:contributor "Howard Dene" xsd:string
property_value: dc:contributor "Melissa Berry" xsd:string
property_value: dc:contributor "Michelle Knowlton" xsd:string
property_value: dc:contributor "Nicole Vasilevsky" xsd:string
property_value: dc:contributor "Paul Schofield" xsd:string
property_value: dc:contributor "Tatsuya Kushida" xsd:string
property_value: dc:contributor "Terue Takatsuki" xsd:string
property_value: dc:contributor "Toyofumi Fujiwara" xsd:string
property_value: dc:creator "Carroll W. Goldsmith" xsd:string
property_value: dc:creator "Cynthia L. Smith" xsd:string
property_value: dc:creator "Janan T. Eppig" xsd:string
property_value: dc:creator "Susan Bello" xsd:string
property_value: dc:description "The Mammalian Phenotype Ontology is being developed by Cynthia L. Smith, Susan M. Bello, Anna, Anagnostopoulos, Carroll W. Goldsmith and Janan T. Eppig, as part of the Mouse Genome Database (MGD) Project, Mouse Genome Informatics (MGI), The Jackson Laboratory, Bar Harbor, ME. This file contains pre-coordinated phenotype terms, definitions and synonyms that can be used to describe mammalian phenotypes. The ontology is represented as a directed acyclic graph (DAG). It organizes phenotype terms into major biological system headers such as nervous system and respiratory system.  This ontology is currently under development. Weekly updates are available at the Mouse Genome Informatics (MGI) ftp site (ftp://ftp.informatics.jax.org/pub/reports/index.html#pheno) as well as the OBO Foundry site (http://obofoundry.org/). Japanese labels of MP were created by the MP Japanese Translation Project (https://github.com/dbcls/MP_Japanse). Questions, comments and suggestions are welcome, and should be directed to pheno@jax.org, Susan.Bello@jax.org or to GitHub tracker (https://github.com/mgijax/mammalian-phenotype-ontology/issues) MGD is funded by NIH/NHGRI grant HG000330." xsd:string
property_value: dc:language "English" xsd:string
property_value: dc:title "The Mammalian Phenotype Ontology" xsd:string
property_value: IAO:0000700 MP:0000001
property_value: owl:versionInfo "2025-02-18" xsd:string
property_value: terms:license https://creativecommons.org/licenses/by/4.0/

[Term]
id: MP:0000001
name: mammalian phenotype
def: "the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]

[Term]
id: MP:0000002
name: obsolete Morphology
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "Anatomy" EXACT []
is_obsolete: true

[Term]
id: MP:0000003
name: abnormal adipose tissue morphology
alt_id: MP:0000011
def: "any structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:cwg]
synonym: "abnormality of adipose tissue" BROAD []
synonym: "adipose tissue abnormalities" BROAD []
synonym: "adipose tissue dysplasia" NARROW []
is_a: MP:0005375 ! adipose tissue phenotype

[Term]
id: MP:0000005
name: increased brown adipose tissue amount
alt_id: MP:0001779
def: "increased amount of the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:cwg]
synonym: "increased brown fat" EXACT []
synonym: "increased brown fat amount" RELATED []
is_a: MP:0001778 ! abnormal brown adipose tissue amount

[Term]
id: MP:0000008
name: increased white adipose tissue amount
alt_id: MP:0001782
def: "increased quantity of fat-storing cells/tissue" [MGI:cwg]
synonym: "increased white fat" EXACT []
synonym: "increased white fat amount" RELATED []
is_a: MP:0001781 ! abnormal white adipose tissue amount

[Term]
id: MP:0000010
name: abnormal abdominal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue in the abdomen" [PMID:8941642]
synonym: "abnormal abdominal fat depot morphology" EXACT []
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0000012
name: obsolete loss of subcutaneous adipose tissue
def: "OBSOLETE. reduction in amount or absence of adipose tissue beneath the skin" [PMID:8941642]
comment: Obsolete.  Use instead the terms decreased subcutaneous adipose tissue amount (MP:0008844) or absent subcutaneous adipose tissue (MP:0008843).
is_obsolete: true
consider: MP:0008843
consider: MP:0008844

[Term]
id: MP:0000013
name: abnormal adipose tissue distribution
def: "alterations in the normal placement of body fat" [PMID:10471508]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal fat distribution" RELATED []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0000015
name: abnormal ear pigmentation
def: "anomaly in the coloration of the skin of the outer ear due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:cwg, MGI:llw2]
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0030530 ! abnormal outer ear skin morphology

[Term]
id: MP:0000017
name: big ears
def: "outer ears of a greater than normal size" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged ears" EXACT []
synonym: "increased outer ear size" EXACT []
synonym: "large ears" EXACT []
synonym: "macrotia" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000018
name: small ears
def: "outer ears of a smaller than normal size" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased ear size" EXACT []
synonym: "microtia" EXACT []
synonym: "reduced ear size" EXACT []
synonym: "reduced pinna size" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000019
name: thick ears
def: "increased width of the epidermal and cartilaginous tissue that makes up the ear" [PMID:1709129]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000020
name: scaly ears
def: "loss of the outer layer of the epidermis of the ears in thick, dry scale-like patches" [PMID:1709129]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000021
name: prominent ears
def: "protuberant outer ears" [PMID:10769039]
synonym: "protruding ears" RELATED []
is_a: MP:0000023 ! abnormal ear position

[Term]
id: MP:0000022
name: abnormal ear shape
def: "any anomaly in the characteristic surface outline or contour of the external ear" [PMID:10921880]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000023
name: abnormal ear position
def: "anomaly in the space between or the placement of the outer ears" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal ear distance/ position" EXACT []
synonym: "abnormal pinna position" EXACT []
synonym: "abnormal pinnae position" EXACT []
synonym: "abnormal position of pinna" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000024
name: lowered ear position
def: "outer ears are situated below the normal location often giving the perception of protruding from the head" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
synonym: "low set ears" EXACT []
synonym: "low-set ears" EXACT []
synonym: "lowset ears" EXACT []
synonym: "melotia" RELATED []
is_a: MP:0000023 ! abnormal ear position

[Term]
id: MP:0000025
name: otic hypertelorism
def: "greater than normal space between the outer ears" [MGI:cwg]
synonym: "hypertelorism of ears" EXACT []
synonym: "increased distance between the ears" EXACT []
is_a: MP:0000023 ! abnormal ear position

[Term]
id: MP:0000026
name: abnormal inner ear morphology
def: "any structural anomaly of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [ISBN:0-683-40008-8]
synonym: "inner ear dysplasia" NARROW []
xref: GO:0042472
is_a: MP:0002102 ! abnormal ear morphology

[Term]
id: MP:0000027
name: obsolete horizontal canal defects
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000028
name: abnormal pars superior vestibularis morphology
def: "any structural anomaly in the part of the vestibular ganglion that receives fibers from the maculae of the utricle and the sacculae and the ampullae of the anterior and lateral semicircular ducts" [ISBN:0-683-40008-8]
synonym: "pars superior vestibularis dysplasia" NARROW []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0002856 ! abnormal vestibular ganglion morphology

[Term]
id: MP:0000029
name: abnormal malleus morphology
def: "any structural anomaly of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0000030
name: abnormal tympanic ring morphology
def: "any structural anomaly of the bony ring at the ear canal to which the tympanic membrane is attached" [ISBN:0-683-40008-8]
synonym: "abnormal ectotympanic" RELATED []
synonym: "tympanic ring dysplasia" NARROW []
is_a: MP:0000049 ! abnormal middle ear morphology

[Term]
id: MP:0000031
name: abnormal cochlea morphology
def: "any structural anomaly of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound" [ISBN:0-683-40008-8]
synonym: "cochlear dysplasia" NARROW []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0000032
name: cochlear degeneration
def: "a retrogressive impairment of function or destruction of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound" [ISBN:0-683-40008-8]
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0000033
name: absent scala media
def: "missing spiral tube within the cochlea that contains the organ of Corti, the neuroepithelial receptor organ for hearing" [ISBN:0-683-40008-8]
synonym: "absent cochlear duct" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0000034
name: abnormal inner ear vestibule morphology
def: "any structural anomaly of the cavity between the semicircular canals and the cochlea of the inner ear" [ISBN:0-683-40008-8]
synonym: "abnormal bony labyrinth vestibule morphology" EXACT []
synonym: "abnormal inner ear vestibulum morphology" EXACT []
synonym: "abnormal osseous labyrinth vestibule morphology" EXACT []
synonym: "abnormal vestibule morphology" BROAD []
synonym: "abnormal vestibule of bony labyrinth morphology" EXACT []
synonym: "vestibular dysplasia" BROAD []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0000035
name: abnormal membranous labyrinth morphology
def: "any structural anomaly of the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [ISBN:0-683-40008-8]
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0000036
name: absent semicircular canals
def: "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [ISBN:0-683-40008-8]
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0000037
name: abnormal lateral semicircular canal morphology
def: "any structural anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, MGI:cwg]
synonym: "horizontal semicircular canal dysplasia" NARROW []
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0000038
name: obsolete thin semicircular canals
def: "OBSOLETE. decreased diameter of the three long bony tubes of the labyrinth that are involved in the sense of balance" [MGI:cwg]
is_obsolete: true
consider: MP:0002428

[Term]
id: MP:0000039
name: abnormal otic capsule morphology
def: "any structural anomaly of the cartilage or bony capsule surrounding the inner ear mechanism" [ISBN:0-683-40008-8]
synonym: "abnormal auditory capsule morphology" EXACT [https://www.medilexicon.com/dictionary/14089]
synonym: "abnormal periotic capsule morphology" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0000040
name: absent middle ear ossicles
def: "missing small bones of the tympanic cavity" [ISBN:0-683-40008-8, PMID:1346922]
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0000041
name: absent endolymphatic duct
def: "missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [ISBN:0-683-40008-8]
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0000042
name: abnormal organ of Corti morphology
def: "any structural anomaly associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [ISBN:0-683-40008-8]
synonym: "abnormal spiral organ morphology" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0000043
name: organ of Corti degeneration
def: "a retrogressive impairment of function or destruction of all or part the highly specialized epithelium in the floor of the ductus cochlearis" [MGI:cwg]
synonym: "degeneration of organ of Corti" EXACT []
is_a: MP:0000032 ! cochlear degeneration
is_a: MP:0000042 ! abnormal organ of Corti morphology

[Term]
id: MP:0000044
name: absent organ of Corti
def: "absence of the highly specialized epithelium in the floor of the ductus cochlearis" [PMID:10072433]
synonym: "absent acoustic papilla" EXACT []
synonym: "absent spiral organ" EXACT []
is_a: MP:0000042 ! abnormal organ of Corti morphology

[Term]
id: MP:0000045
name: abnormal hair cell morphology
def: "any structural anomaly of the sensory epithelial cells of the inner ear" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "abnormal hair cells" BROAD []
synonym: "hair cell dysplasia" NARROW []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0000972 ! abnormal mechanoreceptor morphology

[Term]
id: MP:0000046
name: abnormal sulcus ampullaris morphology
def: "any structural anomaly of the transverse groove on the membranous amupulla of each semicircular duct, where the nerve enters the ampullary crest" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal ampullary groove morphology" EXACT []
synonym: "abnormal ampullary sulcus morphology" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0000047
name: obsolete abnormal interdental cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
replaced_by: MP:0004482

[Term]
id: MP:0000048
name: abnormal stria vascularis morphology
def: "any structural anomaly in the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph; stria vascularis normally consists of marginal, intermediate, and basal cells: basal and marginal cell tight junctions preclude paracellular diffusion into and out of the intrastrial space while basal and intermediate cells secrete into this space potassium ions derived from fibrocytes through gap junctions" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal psalterial cord morphology" EXACT []
synonym: "abnormal stria vascularis ductus cochlearis morphology" EXACT []
synonym: "abnormal vascular stripe morphology" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0000049
name: abnormal middle ear morphology
def: "any structural anomaly of any components of the tympanic cavity or its ossicles" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "middle ear dysplasia" NARROW []
is_a: MP:0002102 ! abnormal ear morphology

[Term]
id: MP:0000051
name: obsolete absent process brevus
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
replaced_by: MP:0003110

[Term]
id: MP:0000052
name: early ear unfolding
def: "early onset of the opening and spreading out of the outer ear" [PMID:9135074]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000053
name: excessive ear growth
def: "overly robust development of the ear" [PMID:9135074]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000054
name: delayed ear emergence
def: "late onset of the growth of the outer ear" [PMID:9722615]
synonym: "delayed ear elevation" EXACT []
synonym: "delayed ear extroversion" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0000060
name: delayed bone ossification
def: "late onset of the formation of bone" [PMID:9144284]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0000061
name: fragile skeleton
alt_id: MP:0001543
def: "easily damaged or broken bones" [PMID:8393145]
synonym: "brittle bones" EXACT []
synonym: "fragile bones" EXACT []
synonym: "general bone weakness" EXACT []
synonym: "increased susceptibility to bone fracture" EXACT []
synonym: "increased susceptibility to fractures" EXACT []
is_a: MP:0001542 ! abnormal bone strength

[Term]
id: MP:0000062
name: increased bone mineral density
alt_id: MP:0010120
def: "increase in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated BMD" EXACT []
synonym: "elevated bone mineral density" EXACT []
synonym: "increased BMD" EXACT []
synonym: "increased bone density" EXACT []
is_a: MP:0010119 ! abnormal bone mineral density

[Term]
id: MP:0000063
name: decreased bone mineral density
alt_id: MP:0010121
def: "reduction in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased BMD" EXACT []
synonym: "decreased bone density" EXACT []
synonym: "osteopenia" NARROW []
synonym: "reduced BMD" EXACT []
synonym: "reduced bone density" EXACT []
synonym: "reduced bone mineral density" EXACT []
is_a: MP:0010119 ! abnormal bone mineral density

[Term]
id: MP:0000064
name: failure of bone resorption
def: "inability to degrade the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts" [PMID:10709991, PMID:1997203]
is_a: MP:0004945 ! abnormal bone resorption

[Term]
id: MP:0000065
name: abnormal bone marrow cavity morphology
def: "any structural anomaly of the medullary cavities of the bones" [ISBN:0-683-40008-8, PMID:10709991]
comment: Note that this term refers to the structure of the cavity itself, not to the contents of the cavity (i.e. the bone marrow).
synonym: "abnormal bone marrow cavities" BROAD []
synonym: "abnormal bone medullary cavity morphology" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0000066
name: osteoporosis
def: "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10471508]
synonym: "reduced bone mass" RELATED []
is_a: MP:0004016 ! decreased bone mass

[Term]
id: MP:0000067
name: osteopetrosis
def: "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis" [ISBN:0-683-40008-8, MESH:C05.116.099.708.702.678]
is_a: MP:0005605 ! increased bone mass

[Term]
id: MP:0000069
name: kyphoscoliosis
def: "kyphosis combined with scoliosis" [MGI:cml, PMID:11136708]
synonym: "scoliokyphosis" EXACT []
is_a: MP:0000160 ! kyphosis
is_a: MP:0000161 ! scoliosis

[Term]
id: MP:0000071
name: axial skeleton hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the axial skeleton, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10572046]
synonym: "hypoplastic axial skeleton" EXACT []
is_a: MP:0002114 ! abnormal axial skeleton morphology

[Term]
id: MP:0000073
name: absent craniofacial bones
def: "missing skeletal elements comprising the cranium and face" [PMID:8837770]
synonym: "absence of craniofacial bones" EXACT []
is_a: MP:0002116 ! abnormal craniofacial bone morphology

[Term]
id: MP:0000074
name: abnormal neurocranium morphology
alt_id: MP:0000076
def: "any structural anomaly of the bones of the skull enclosing the brain" [ISBN:0-683-40008-8, PMID:10572046]
synonym: "abnormal calvaria morphology" EXACT []
synonym: "abnormal cranial vault morphology" EXACT []
synonym: "calvaria dysplasia" NARROW []
synonym: "neurocranium dysplasia" NARROW []
is_a: MP:0000438 ! abnormal cranium morphology

[Term]
id: MP:0000075
name: absent neurocranium
def: "missing bones of the skull enclosing the brain" [ISBN:0-683-40008-8, PMID:9753320]
synonym: "absence of neurocranium" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0000077
name: abnormal interparietal bone morphology
alt_id: MP:0000110
def: "any structural anomaly of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [https://orcid.org/0000-0003-3691-0324, PMID:10742104]
synonym: "interparietal bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0000078
name: abnormal supraoccipital bone morphology
def: "any structural anomaly of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [PMID:10742104]
comment: The basioccipital, exoccipital and supraoccipital bones are distinct bones in prenatal, neonatal and some early juvenile stages in most mammals. In adult organisms, these structures are fused to form the unified adult occipital bone.
synonym: "supraoccipital bone dysplasia" NARROW []
is_a: MP:0005269 ! abnormal occipital bone morphology

[Term]
id: MP:0000079
name: abnormal basioccipital bone morphology
def: "any structural anomaly of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8]
comment: The basioccipital, exoccipital and supraoccipital bones are distinct bones in prenatal, neonatal and some early juvenile stages in most mammals. In adult organisms, these structures are fused to form the unified adult occipital bone.
synonym: "basioccipital bone dysplasia" NARROW []
is_a: MP:0005269 ! abnormal occipital bone morphology
is_a: MP:0010029 ! abnormal basicranium morphology

[Term]
id: MP:0000080
name: abnormal exoccipital bone morphology
def: "any structural anomaly of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8, PMID:1680563]
comment: The basioccipital, exoccipital and supraoccipital bones are distinct bones in prenatal, neonatal and some early juvenile stages in most mammals. In adult organisms, these structures are fused to form the unified adult occipital bone.
synonym: "exoccipital bone dysplasia" NARROW []
is_a: MP:0005269 ! abnormal occipital bone morphology

[Term]
id: MP:0000081
name: premature cranial suture closure
alt_id: MP:0005268
def: "early closure of one or more of the joints (sutures) between the bones of the skull; can cause alterations in head shape, facial features, brain growth and, in rare cases, damage to the brain due to increased pressure inside the skull" [https://rarediseases.info.nih.gov/diseases/6209/craniosynostosis, PMID:7597092]
subset: CvDC_Terms
synonym: "cranial suture synostosis" EXACT []
synonym: "craniostosis" EXACT []
synonym: "craniosynostosis" EXACT []
synonym: "early fusion of cranial sutures" EXACT []
xref: Fyler:4336
is_a: MP:0030435 ! premature craniofacial suture closure

[Term]
id: MP:0000082
name: overlapping parietal bones
def: "parietal bones of the skull partly coincide instead of articulating" [PMID:7597092]
is_a: MP:0000109 ! abnormal parietal bone morphology

[Term]
id: MP:0000083
name: obsolete ectopic cranial bone growth
def: "OBSOLETE. growth of extra bony structures in or near the cranium" [PMID:7597092]
synonym: "heterotopic cranial bone growth" EXACT []
is_obsolete: true
replaced_by: MP:0014166

[Term]
id: MP:0000084
name: abnormal fontanelle morphology
def: "any structural anomaly in the membranous interval at the margins of cranial bones in neonates" [ISBN:0-683-40008-8, PMID:9949198]
synonym: "abnormal fontanel morphology" EXACT []
synonym: "fontanelle dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology
is_a: MP:0002113 ! abnormal skeleton development
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0000085
name: large anterior fontanelle
def: "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [ISBN:0-683-40008-8, PMID:9949198]
synonym: "enlarged anterior fontanelle" EXACT []
synonym: "enlarged frontal fontanelle" EXACT []
synonym: "large anterior fontanel" EXACT []
synonym: "large frontal fontanelle" EXACT []
is_a: MP:0030363 ! abnormal anterior fontanelle morphology
is_a: MP:0030388 ! large fontanelles

[Term]
id: MP:0000087
name: absent mandible
def: "missing the lower bony framework of the mouth where the inferior teeth are held" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absence of lower jaw" EXACT []
synonym: "absence of mandible" EXACT []
synonym: "absent lower jaw" EXACT []
synonym: "agenesis of the lower jaw bone" EXACT []
synonym: "agenesis of the mandible" EXACT []
synonym: "aplasia of the lower jaw bone" EXACT []
synonym: "aplasia of the mandible" EXACT []
synonym: "mandibular agenesis" EXACT []
synonym: "mandibular agnathia" EXACT []
synonym: "mandibular aplasia" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030268 ! agnathia
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0000088
name: short mandible
def: "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [MGI:cwg]
synonym: "reduced mandible length" EXACT []
synonym: "truncated mandible" EXACT []
is_a: MP:0004592 ! small mandible
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0000090
name: absent premaxilla
def: "missing anterior and interior portion of the maxilla" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "absence of premaxilla" EXACT []
is_a: MP:0002820 ! abnormal premaxilla morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0000091
name: short premaxilla
def: "length reduction or truncation of the anterior and interior portion of the maxilla" [ISBN:0-683-40008-8, PMID:9949198]
synonym: "short incisive bone" EXACT []
synonym: "truncated premaxilla" EXACT []
is_a: MP:0004870 ! small premaxilla
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0000094
name: absent alveolar process
def: "missing projecting ridge on the inferior surface of the body of the maxilla and mandible containing the tooth sockets" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "absence of alveolar process" EXACT []
synonym: "absent alveolar bone" EXACT []
synonym: "absent alveolar ridge" EXACT []
is_a: MP:0004189 ! abnormal alveolar process morphology

[Term]
id: MP:0000097
name: short maxilla
alt_id: MP:0000093
def: "reduced length of the upper jaw bone" [ISBN:0-683-40008-8, PMID:9949198]
synonym: "decreased maxilla length" EXACT []
synonym: "reduced maxilla length" EXACT []
synonym: "reduced upper jaw length" EXACT []
is_a: MP:0004540 ! small maxilla
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0000098
name: abnormal vomer bone morphology
def: "any structural anomaly of the triangular flat bone of the nasal septum" [ISBN:0-683-40008-8]
synonym: "vomer bone dysplasia" NARROW []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0000099
name: absent vomer bone
def: "missing triangular flat bone of the nasal septum" [ISBN:0-683-40008-8, PMID:9753320]
synonym: "absence of vomer bone" EXACT []
is_a: MP:0000098 ! abnormal vomer bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0000100
name: abnormal ethmoid bone morphology
def: "any structural anomaly of the single midline facial bone that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits; it is cubical in shape, relatively lightweight because of its spongy construction, and contributes to the anterior cranial fossa" [https://radiopaedia.org/articles/ethmoid-bone-1, ISBN:0-683-40008-8]
synonym: "abnormal ethmoidal bone morphology" EXACT []
synonym: "ethmoid bone dysplasia" NARROW []
synonym: "ethmoidal bone dysplasia" NARROW []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0000101
name: absent ethmoid bone
def: "missing the single midline facial bone that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits; it is cubical in shape, relatively lightweight because of its spongy construction, and contributes to the anterior cranial fossa" [https://radiopaedia.org/articles/ethmoid-bone-1, ISBN:0-683-40008-8, PMID:9753320]
synonym: "absent ethmoidal bone" EXACT []
is_a: MP:0000100 ! abnormal ethmoid bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0000102
name: abnormal nasal bone morphology
def: "any structural anomaly of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "nasal bone dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0000103
name: nasal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the nasal bone, typically resulting in decreased size" [PMID:9949198]
synonym: "hypoplastic nasal bone" EXACT []
is_a: MP:0004470 ! small nasal bone
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0000104
name: abnormal sphenoid bone morphology
def: "any structural anomaly of the irregularly shaped bone of the base of the skull" [ISBN:0-683-40008-8, PMID:9753320]
synonym: "sphenoid bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0000105
name: impaired ossification of basisphenoid bone
def: "anomaly in the formation of the bone at the base of the sphenoid bone; arises from an ossification center independent of the remainder of the sphenoid bone" [ISBN:0-683-40008-8, PMID:9753320]
synonym: "defective ossification of basisphenoid" EXACT []
is_a: MP:0000106 ! abnormal basisphenoid bone morphology
is_a: MP:0008273 ! abnormal intramembranous bone ossification

[Term]
id: MP:0000106
name: abnormal basisphenoid bone morphology
def: "any structural anomaly of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8]
synonym: "basisphenoid bone dysplasia" NARROW []
is_a: MP:0000104 ! abnormal sphenoid bone morphology
is_a: MP:0010029 ! abnormal basicranium morphology

[Term]
id: MP:0000107
name: abnormal frontal bone morphology
def: "any structural anomaly of the single bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "frontal bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0000108
name: midline facial cleft
def: "incomplete merging or fusion of the tissues (e.g. the two globular processes) along the facial midline that normally unite to form the face" [ISBN:0-683-40008-8, PMID:9753320]
synonym: "median facial cleft" EXACT []
synonym: "mid-face cleft" EXACT []
synonym: "mid-facial cleft" EXACT []
synonym: "midfacial cleft" EXACT []
is_a: MP:0008797 ! facial cleft

[Term]
id: MP:0000109
name: abnormal parietal bone morphology
def: "any structural anomaly of either of a pair of membranous bones of the roof of the skull located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723, https://quizlet.com/222497251/cranial-bones-flash-cards/, https://www.merriam-webster.com/dictionary/parietal%20bone]
synonym: "parietal bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0000111
name: cleft palate
alt_id: MP:0000429
def: "congenital fissure of the tissues normally uniting to form the palate" [ISBN:0-683-40008-8, PMID:9753320]
subset: CvDC_Terms
subset: IMPC_Prenatal
synonym: "palatoschisis" EXACT []
xref: Fyler:4876
is_a: MP:0003755 ! abnormal palate morphology
is_a: MP:0021164 ! oral cleft

[Term]
id: MP:0000114
name: cleft chin
def: "incomplete fusion of the chin; usually a fissure" [ISBN:0-683-40008-8, PMID:9256350]
is_a: MP:0030243 ! abnormal chin morphology

[Term]
id: MP:0000116
name: abnormal tooth development
def: "any anomaly in the formation of the teeth" [MGI:cwg]
synonym: "abnormal odontogenesis" EXACT []
synonym: "abnormal odontogeny" EXACT []
synonym: "abnormal odontosis" EXACT []
synonym: "abnormal tooth morphogenesis" EXACT []
synonym: "tooth development abnormalities" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0000117
name: absent tooth placode
def: "missing the local thickening that is normally formed within the primary dental lamina and grows into a solid epithelial tooth bud that invades the underlying mesenchyme; the placodes consist of thickened epithelium and underlying neural crest derived mesenchyme, and they function as the first signaling centers of the tooth" [https://orcid.org/0000-0002-6490-7723, https://www.ncbi.nlm.nih.gov/books/NBK27071/, PMID:10227294]
synonym: "absence of tooth anlage" EXACT []
synonym: "absence of tooth primordium" EXACT []
synonym: "absent dental anlage" EXACT []
synonym: "absent dental placode" EXACT []
synonym: "absent dental primordium" EXACT []
synonym: "absent odontogenic placode" EXACT []
synonym: "absent tooth anlage" EXACT []
synonym: "absent tooth primordia" EXACT []
synonym: "absent tooth primordium" EXACT []
is_a: MP:0030510 ! abnormal tooth placode morphology

[Term]
id: MP:0000118
name: arrest of tooth development
def: "failure of differentiation of the teeth" [PMID:7958926]
is_a: MP:0000116 ! abnormal tooth development

[Term]
id: MP:0000119
name: abnormal tooth eruption
def: "any anomaly in the developmental process in which a tooth moves in an axial and occlusal direction from its developmental position within the alveolar crypt in the jaw to its final functional position in the occlusal plane" [https://books.google.com/books?isbn=8131240363, https://orcid.org/0000-0002-6490-7723]
synonym: "tooth eruption abnormalities" EXACT []
is_a: MP:0000116 ! abnormal tooth development

[Term]
id: MP:0000120
name: malocclusion
def: "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [PMID:10742104]
subset: IMPC
subset: Sanger_Terms
synonym: "bad bite" EXACT []
synonym: "dental malocclusion" EXACT []
synonym: "malalignment of upper and lower dental arches" EXACT []
synonym: "malocclusion of teeth" EXACT []
synonym: "misalignment of upper and lower dental arches" EXACT []
is_a: MP:0030540 ! misaligned teeth

[Term]
id: MP:0000121
name: failure of tooth eruption
def: "inability of the teeth to grow into the oral cavity" [ISBN:0-683-40008-8, PMID:10709991]
is_a: MP:0000119 ! abnormal tooth eruption

[Term]
id: MP:0000122
name: premature tooth eruption
def: "early onset of the growth of the teeth out of the gums" [PMID:1709129]
is_a: MP:0000119 ! abnormal tooth eruption

[Term]
id: MP:0000124
name: obsolete absent teeth
def: "OBSOLETE. absence of some or all of the bony structures of the upper and lower jaws used in mastication" [ISBN:0-683-40008-8, PMID:10709991]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_obsolete: true
replaced_by: MP:0030610

[Term]
id: MP:0000125
name: absent incisors
def: "absence of the pairs of long teeth that are the most anterior and prominent in the jaw" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "absence of incisors" EXACT []
is_a: MP:0030609 ! decreased incisor number

[Term]
id: MP:0000126
name: brittle teeth
def: "fragile and likely to break teeth" [PMID:10742104]
is_a: MP:0002100 ! abnormal tooth morphology

[Term]
id: MP:0000127
name: degenerate molars
def: "deterioration or loss over time of the molars" [https://orcid.org/0000-0003-3691-0324]
synonym: "degenerated molars" EXACT []
is_a: MP:0002689 ! abnormal molar morphology

[Term]
id: MP:0000128
name: growth retardation of molars
def: "developmental delay of the growth of the molars" [PMID:7914451]
is_a: MP:0000116 ! abnormal tooth development

[Term]
id: MP:0000129
name: ameloblast degeneration
def: "a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [ISBN:0-683-40008-8, PMID:10742104]
synonym: "degeneration of ameloblasts" EXACT []
is_a: MP:0002650 ! abnormal ameloblast morphology

[Term]
id: MP:0000130
name: abnormal trabecular bone morphology
def: "any structural anomaly of bone that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal cancellous bone morphology" EXACT []
synonym: "abnormal spongy bone morphology" EXACT []
synonym: "abnormal spongy spongiosa morphology" EXACT []
synonym: "abnormal spongy substance morphology" EXACT []
synonym: "abnormal substantia trabecularis morphology" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0000131
name: abnormal long bone epiphysis morphology
def: "any structural anomaly of the rounded end of a long bone" [PMID:10742104]
synonym: "abnormal epiphysis morphology" EXACT []
synonym: "long bone epiphysis dysplasia" NARROW []
is_a: MP:0002113 ! abnormal skeleton development
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0000132
name: thickened long bone epiphysis
def: "wider than normal rounded end of a long bone" [ISBN:0-683-40008-8, PMID:10709991]
synonym: "thick epiphysis" EXACT []
is_a: MP:0000131 ! abnormal long bone epiphysis morphology

[Term]
id: MP:0000133
name: abnormal long bone metaphysis morphology
def: "any structural anomaly of the conical section of bone between the epiphysis and diaphysis of the long bones; this section grows during childhood and juvenile stages and is completely ossified in adults" [ISBN:0-683-40008-8, PMID:10709991]
synonym: "abnormal metaphysis morphology" EXACT []
synonym: "long bone metaphysis dysplasia" NARROW []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0000134
name: abnormal compact bone thickness
def: "reduced or increased width of the superficial layer of compact bone" [ISBN:0-683-40008-8, PMID:10581033]
synonym: "abnormal cortical bone thickness" RELATED []
is_a: MP:0003797 ! abnormal compact bone morphology

[Term]
id: MP:0000135
name: decreased compact bone thickness
def: "thinner than normal superficial layer of compact bone" [PMID:10742104]
synonym: "decreased cortical bone thickness" EXACT []
synonym: "reduced compact bone thickness" EXACT []
synonym: "reduced cortical bone thickness" EXACT []
synonym: "thin compact bone" EXACT []
synonym: "thin cortical bone" EXACT []
is_a: MP:0000134 ! abnormal compact bone thickness

[Term]
id: MP:0000136
name: abnormal microglial cell morphology
def: "any structural anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques" [PMID:16322748]
is_a: MP:0000952 ! abnormal CNS glial cell morphology
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0000137
name: abnormal vertebrae morphology
alt_id: MP:0001538
def: "any structural anomaly of the bony segments of the spinal column" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal vertebra" BROAD []
synonym: "vertebra defect" BROAD []
synonym: "vertebra dysplasia" NARROW []
synonym: "vertebral anomaly" BROAD []
xref: Fyler:4108
is_a: MP:0004703 ! abnormal vertebral column morphology

[Term]
id: MP:0000138
name: absent vertebrae
def: "missing all of the bony segments of the spinal column" [PMID:8837770]
synonym: "absence of vertebrae" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0000139
name: absent vertebral transverse processes
def: "loss of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes" [PMID:10804168, PMID:10804169]
synonym: "absence of transverse processes" EXACT []
is_a: MP:0004600 ! abnormal vertebral transverse process morphology

[Term]
id: MP:0000140
name: absent vertebral pedicles
def: "loss of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8, PMID:10804168, PMID:10804169]
synonym: "absence of pedicles" EXACT []
is_a: MP:0004604 ! abnormal vertebral pedicle morphology

[Term]
id: MP:0000141
name: abnormal vertebral body morphology
def: "any structural anomaly of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8, PMID:10572046]
synonym: "abnormal vertebral bodies" BROAD []
synonym: "vertebral body dysplasia" NARROW []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0000142
name: obsolete An Extra Piece of Bone Rostral to C1
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000143
name: obsolete Broadening/Splitting of the Neural Arch of C2
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0004608
consider: MP:0010703

[Term]
id: MP:0000148
name: obsolete abnormal shoulder/ pelvic girdle morphology
alt_id: MP:0001540
def: "OBSOLETE. any structural anomaly of the bones of the shoulder or of the bones of the pelvis by which the limbs attach to the axial skeleton" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal shoulder/ pelvic girdle" EXACT []
synonym: "shoulder/ pelvic girdle defect" EXACT []
is_obsolete: true
consider: MP:0004508
consider: MP:0004509

[Term]
id: MP:0000149
name: abnormal scapula morphology
def: "any structural anomaly of either or both of the large, flat bones of the back part of the shoulder" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "scapula dysplasia" NARROW []
is_a: MP:0004508 ! abnormal pectoral girdle bone morphology

[Term]
id: MP:0000150
name: abnormal rib morphology
def: "any structural anomaly of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8, PMID:9778510]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal ribs" BROAD []
synonym: "rib defect" BROAD []
synonym: "rib dysplasia" NARROW []
is_a: MP:0004624 ! abnormal thoracic cage morphology

[Term]
id: MP:0000151
name: absent ribs
def: "absence of all the pairs of bony structures that make up the body wall" [PMID:7925010]
synonym: "absence of ribs" EXACT []
is_a: MP:0003345 ! decreased rib number

[Term]
id: MP:0000152
name: absent proximal rib
def: "missing part of rib structures near the spine, ribs do not contact vertebrae" [PMID:10804168, PMID:10804169]
synonym: "absence of proximal ribs" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0000153
name: rib bifurcation
def: "forking or division of ribs, may be a result of partial rib fusions" [ISBN:0-683-40008-8]
synonym: "rib splitting" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0000154
name: rib fusion
def: "appearance of one or more ribs as a single structure" [PMID:10804168, PMID:10804169]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "fused ribs" EXACT []
synonym: "fusion of ribs" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0000155
name: asymmetric rib joints
def: "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [PMID:7925010]
synonym: "asymmetric rib articulation" EXACT []
synonym: "asymmetric rib attachment" EXACT []
is_a: MP:0004625 ! abnormal rib joint morphology

[Term]
id: MP:0000156
name: obsolete Presence of 6 Vertebrosternal Ribs instead of 7
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0000480

[Term]
id: MP:0000157
name: abnormal sternum morphology
def: "any structural anomaly of the long flat bone of the chest that articulates with clavicle and first seven rib pairs; from rostral to caudal positions, the sternum consists of three parts: manubrium, body, and xiphoid process" [ISBN:0-683-40008-8, PMID:7925010]
synonym: "sternum defect" BROAD []
synonym: "sternum dysplasia" NARROW []
is_a: MP:0004508 ! abnormal pectoral girdle bone morphology
is_a: MP:0004624 ! abnormal thoracic cage morphology

[Term]
id: MP:0000158
name: absent sternum
def: "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [ISBN:0-683-40008-8, PMID:10885747]
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0000159
name: abnormal xiphoid process morphology
def: "any structural anomaly of the caudal tip of the sternum" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal xiphisternum morphology" EXACT []
synonym: "abnormal xiphoid cartilage morphology" EXACT []
synonym: "xiphoid process defect" BROAD []
synonym: "xyphoid process dysplasia" NARROW []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0000160
name: kyphosis
alt_id: MP:0000068
def: "forward curvature of the spine, characterized by extensive flexion" [ISBN:0-683-40008-8, MGI:cml, PMID:10804168, PMID:11136708]
subset: IMPC
subset: Sanger_Terms
synonym: "humpback" EXACT []
synonym: "hunchback" EXACT []
is_a: MP:0004174 ! abnormal spine curvature

[Term]
id: MP:0000161
name: scoliosis
alt_id: MP:0000070
def: "lateral and rotational curvature of the spine" [ISBN:0-683-40008-8, PMID:11136708, PMID:9949198]
subset: CvDC_Terms
subset: IMPC
subset: Sanger_Terms
xref: Fyler:4160
is_a: MP:0004174 ! abnormal spine curvature

[Term]
id: MP:0000162
name: lordosis
def: "anteriorly convex curvature of the spine" [ISBN:0-683-40008-8, PMID:10804169]
subset: IMPC
subset: Sanger_Terms
synonym: "saddle back" EXACT []
is_a: MP:0004174 ! abnormal spine curvature

[Term]
id: MP:0000163
name: abnormal cartilage morphology
def: "any structural anomaly of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life" [ISBN:0-683-40008-8]
synonym: "cartilage dysplasia" NARROW []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0000164
name: abnormal cartilage development
def: "anomaly in the formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life" [ISBN:0-683-40008-8]
synonym: "abnormal cartilage formation" EXACT []
synonym: "abnormal chondrogenesis" EXACT []
synonym: "dyschondrogenesis" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0000165
name: abnormal long bone hypertrophic chondrocyte zone
def: "anomaly of the layer of the epiphyseal plate of a long bone where chondrocytes mature and enlarge" [ISBN:0-683-40008-8, PMID:10581033]
synonym: "abnormal long bone zone of hypertrophy" RELATED []
is_a: MP:0000164 ! abnormal cartilage development
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0000166
name: abnormal chondrocyte morphology
def: "any structural anomaly of a polymorphic cell that forms cartilage" [CL:0000138]
synonym: "abnormal chondrocytes" BROAD []
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0000167
name: decreased chondrocyte number
def: "fewer than normal numbers of polymorphic cells that form cartilage" [CL:0000138]
synonym: "decreased chondrocyte cell number" EXACT []
synonym: "decreased number of chondrocytes" EXACT []
synonym: "reduced chondrocyte numbers" EXACT []
is_a: MP:0000166 ! abnormal chondrocyte morphology

[Term]
id: MP:0000168
name: abnormal bone marrow development
def: "anomaly in the formation of the soft, pulpy tissue filling the medullary cavities of bones" [ISBN:0-683-40008-8]
synonym: "abnormal bone marrow formation" EXACT []
is_a: MP:0002450 ! abnormal lymph organ development

[Term]
id: MP:0000172
name: abnormal bone marrow cell number
def: "increased or decreased number of cells that make up the core cavities of bones when compared to controls" [MGI:tc]
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development

[Term]
id: MP:0000175
name: absent bone marrow cell
alt_id: MP:0000342
def: "lack of all cells that make up the core cavities of bones" [MGI:cwg]
synonym: "absence of bone marrow cell" EXACT []
synonym: "Loss of bone marrow cell" RELATED []
synonym: "loss of bone marrow cell" RELATED []
is_a: MP:0000333 ! decreased bone marrow cell number

[Term]
id: MP:0000176
name: obsolete bone marrow occupied by adipocytes
def: "OBSOLETE. anomalous appearance of fat-forming cells in the bone marrow" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0000180
name: abnormal circulating cholesterol level
alt_id: MP:0001549
alt_id: MP:0005177
def: "anomaly in the amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [ISBN:0-683-40008-8]
synonym: "abnormal cholesterol level" BROAD []
synonym: "abnormal total circulating cholesterol level" NARROW []
synonym: "abnormal total plasma cholesterol level" NARROW []
synonym: "abnormal total serum cholesterol level" NARROW []
is_a: MP:0003947 ! abnormal cholesterol level
is_a: MP:0003949 ! abnormal circulating lipid level

[Term]
id: MP:0000181
name: abnormal circulating LDL cholesterol level
def: "any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal blood LDL cholesterol level" EXACT []
synonym: "abnormal circulating beta-lipoprotein level" RELATED []
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0020151 ! abnormal circulating non-HDL cholesterol level

[Term]
id: MP:0000182
name: increased circulating LDL cholesterol level
def: "greater amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated circulating LDL cholesterol level" EXACT []
synonym: "elevated LDL cholesterol level" BROAD []
synonym: "high LDL cholesterol level" BROAD []
synonym: "increased circulating beta-lipoprotein level" RELATED []
synonym: "increased LDL cholesterol level" BROAD []
is_a: MP:0000181 ! abnormal circulating LDL cholesterol level
is_a: MP:0005178 ! increased circulating cholesterol level

[Term]
id: MP:0000183
name: decreased circulating LDL cholesterol level
def: "reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating beta-lipoprotein level" RELATED []
synonym: "decreased LDL cholesterol level" BROAD []
synonym: "low circulating LDL cholesterol level" EXACT []
synonym: "low LDL cholesterol level" BROAD []
synonym: "reduced circulating LDL cholesterol level" EXACT []
is_a: MP:0000181 ! abnormal circulating LDL cholesterol level
is_a: MP:0005179 ! decreased circulating cholesterol level

[Term]
id: MP:0000184
name: abnormal circulating HDL cholesterol level
alt_id: MP:0001555
def: "any anomaly in the amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal HDL cholesterol level" BROAD []
synonym: "abnormal HDL levels" BROAD []
is_a: MP:0000180 ! abnormal circulating cholesterol level
is_a: MP:0010330 ! abnormal circulating lipoprotein level

[Term]
id: MP:0000186
name: decreased circulating HDL cholesterol level
alt_id: MP:0002618
def: "reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased HDL cholesterol level" BROAD []
synonym: "low circulating HDL cholesterol level" EXACT []
synonym: "low HDL cholesterol level" BROAD []
synonym: "low serum HDL level" NARROW []
synonym: "reduced circulating HDL level" EXACT []
is_a: MP:0000184 ! abnormal circulating HDL cholesterol level
is_a: MP:0005179 ! decreased circulating cholesterol level

[Term]
id: MP:0000187
name: abnormal triglyceride level
alt_id: MP:0001551
def: "any anomaly in the concentration of triglyceride, a glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal triacylglycerol level" EXACT []
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0000188
name: abnormal circulating glucose level
alt_id: MP:0001557
def: "any anomaly in the concentration in the blood of the major monosaccharide of the body" [MGI:cwg]
synonym: "abnormal blood glucose level" EXACT []
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0000189
name: hypoglycemia
alt_id: MP:0001558
alt_id: MP:0002613
def: "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "Decreased Blood Glucose Level" BROAD []
synonym: "hypoglycaemia" EXACT []
synonym: "low blood glucose levels" BROAD []
is_a: MP:0005560 ! decreased circulating glucose level

[Term]
id: MP:0000192
name: abnormal mineral level
alt_id: MP:0001561
def: "any anomaly in the concentration of any inorganic substance that has importance in body functions" [ISBN:0-683-40008-8]
is_a: MP:0005636 ! abnormal mineral homeostasis

[Term]
id: MP:0000194
name: increased circulating calcium level
alt_id: MP:0001563
alt_id: MP:0001768
def: "abnormally high concentration of calcium ions in the circulating blood" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypercalcaemia" EXACT []
synonym: "hypercalcemia" EXACT []
synonym: "increased circulating calcium" EXACT []
is_a: MP:0001562 ! abnormal circulating calcium level
is_a: MP:0014537 ! increased calcium level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0000195
name: decreased circulating calcium level
alt_id: MP:0001564
alt_id: MP:0001769
def: "subnormal concentrations of calcium ions in the circulating blood" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating calcium" EXACT []
synonym: "hypocalcaemia" EXACT []
synonym: "hypocalcemia" EXACT []
synonym: "reduced circulating calcium level" EXACT []
is_a: MP:0001562 ! abnormal circulating calcium level
is_a: MP:0014538 ! decreased calcium level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0000198
name: decreased circulating phosphate level
alt_id: MP:0001567
alt_id: MP:0001774
def: "abnormally low concentrations of phosphates in the circulating blood" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypophosphataemia" EXACT []
synonym: "hypophosphatemia" EXACT []
synonym: "reduced circulating phospate level" EXACT []
is_a: MP:0001565 ! abnormal circulating phosphate level
is_a: MP:0014546 ! decreased phosphate level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0000199
name: abnormal circulating serum albumin level
alt_id: MP:0001568
def: "anomaly in the blood level of the major blood protein that is important in maintaining the colloidal osmotic pressure, fatty acid transport and transporting large organic molecules" [MESH:D12.776.034.841]
synonym: "abnormal albumin level" BROAD []
is_a: MP:0005416 ! abnormal circulating protein level

[Term]
id: MP:0000202
name: abnormal circulating alkaline phosphatase level
alt_id: MP:0001571
def: "any anomaly in the concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia" [ISBN:0-683-40008-8]
synonym: "abnormal alkaline phosphatase level" BROAD []
synonym: "abnormal AP level" BROAD []
synonym: "abnormal circulating ALP levels" EXACT []
xref: GO:0004035
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0000203
name: abnormal circulating aspartate transaminase level
alt_id: MP:0001572
def: "any anomaly in the concentration in the blood of the enzyme which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid" [ISBN:0-683-40008-8]
synonym: "abnormal aspartate aminotransferase level" BROAD []
synonym: "abnormal aspartate transaminase level" BROAD []
synonym: "abnormal AST level" BROAD []
synonym: "abnormal circulating AAT level" EXACT []
synonym: "abnormal circulating ASAT level" EXACT []
synonym: "abnormal circulating serum glutamic oxaloacetic transaminase level" EXACT []
synonym: "abnormal circulating SGOT level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0000208
name: decreased hematocrit
alt_id: MP:0001580
def: "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MESH:E01.450.375.400]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased haematocrit" EXACT []
synonym: "reduced haematocrit" EXACT []
synonym: "reduced hematocrit" EXACT []
is_a: MP:0002596 ! abnormal hematocrit

[Term]
id: MP:0000215
name: absent erythrocytes
def: "lack of mature red blood cells" [PMID:7830794]
synonym: "absence of erythrocytes" EXACT []
synonym: "absence of RBCs" EXACT []
synonym: "absence of red blood cells" EXACT []
synonym: "absent definitive erythrocyte" EXACT []
is_a: MP:0002875 ! decreased erythrocyte cell number

[Term]
id: MP:0000216
name: absent erythroid progenitor cell
def: "lack of progenitors of the erythrocyte lineage" [CL:0000038, PMID:7830794]
synonym: "absence of erythrocyte precursors" EXACT []
synonym: "absent BFU-E" RELATED []
synonym: "absent blast forming unit erythroid" RELATED []
synonym: "absent burst forming unit erythroid" RELATED []
synonym: "absent CFU-E" RELATED []
synonym: "absent colony forming unit erythroid" RELATED []
synonym: "absent erythrocyte precursors" EXACT []
synonym: "absent erythroid stem cell" RELATED []
is_a: MP:0008973 ! decreased erythroid progenitor cell number

[Term]
id: MP:0000217
name: abnormal leukocyte cell number
alt_id: MP:0001587
def: "any anomaly in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
synonym: "abnormal leucocyte cell number" EXACT []
synonym: "abnormal WBC cell" EXACT []
synonym: "abnormal white blood cell count" EXACT []
synonym: "abnormal white blood cell number" EXACT []
synonym: "leucocyte count abnormalities" EXACT []
synonym: "leukocyte count abnormalities" EXACT []
synonym: "white blood cell count abnormalities" EXACT []
synonym: "white blood cell number abnormalities" EXACT []
is_a: MP:0008246 ! abnormal leukocyte morphology
is_a: MP:0011180 ! abnormal hematopoietic cell number

[Term]
id: MP:0000218
name: increased leukocyte cell number
def: "greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased leucocyte cell number" EXACT []
synonym: "increased leucocyte count" EXACT []
synonym: "increased leukocyte count" EXACT []
synonym: "increased WBC count" EXACT []
synonym: "increased WBC number" EXACT []
synonym: "increased white blood cell number" EXACT []
synonym: "leucocytosis" EXACT []
synonym: "leukocytosis" EXACT []
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0011181 ! increased hematopoietic cell number

[Term]
id: MP:0000219
name: increased neutrophil cell number
def: "greater than normal number of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [CL:0000775, https://orcid.org/0000-0003-3691-0324]
synonym: "increased neutrophil count" EXACT []
synonym: "increased neutrophil number" EXACT []
synonym: "neutrophilia" EXACT []
is_a: MP:0000322 ! increased granulocyte number
is_a: MP:0012440 ! abnormal neutrophil cell number

[Term]
id: MP:0000220
name: increased monocyte cell number
def: "greater count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased monocyte count" EXACT []
synonym: "increased monocyte number" EXACT []
synonym: "monocytosis" EXACT []
is_a: MP:0000218 ! increased leukocyte cell number
is_a: MP:0012441 ! abnormal monocyte cell number

[Term]
id: MP:0000221
name: decreased leukocyte cell number
def: "reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased leucocyte count" EXACT []
synonym: "decreased leukocyte count" EXACT []
synonym: "decreased WBC count" EXACT []
synonym: "decreased WBC number" EXACT []
synonym: "decreased white blood cell number" EXACT []
synonym: "leucocytopenia" EXACT []
synonym: "leucopenia" EXACT []
synonym: "leukocytopenia" EXACT []
synonym: "leukopenia" EXACT []
synonym: "lymphopenia" NARROW []
synonym: "reduced leucocyte cell number" EXACT []
synonym: "reduced leucocyte count" EXACT []
synonym: "reduced leukocyte cell number" EXACT []
synonym: "reduced leukocyte count" EXACT []
synonym: "reduced WBC count" EXACT []
synonym: "reduced WBC number" EXACT []
synonym: "reduced white blood cell number" EXACT []
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0011182 ! decreased hematopoietic cell number

[Term]
id: MP:0000222
name: decreased neutrophil cell number
def: "reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [CL:0000775, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased neutrophil count" EXACT []
synonym: "decreased neutrophil number" EXACT []
synonym: "neutropenia" EXACT []
synonym: "reduced neutrophil cell number" EXACT []
synonym: "reduced neutrophil count" EXACT []
is_a: MP:0000334 ! decreased granulocyte number
is_a: MP:0012440 ! abnormal neutrophil cell number

[Term]
id: MP:0000223
name: decreased monocyte cell number
def: "reduced count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased monocyte count" EXACT []
synonym: "decreased monocyte number" EXACT []
synonym: "monocytopenia" EXACT []
synonym: "reduced monocyte cell number" EXACT []
synonym: "reduced monocyte count" EXACT []
is_a: MP:0000221 ! decreased leukocyte cell number
is_a: MP:0012441 ! abnormal monocyte cell number

[Term]
id: MP:0000226
name: abnormal mean corpuscular volume
alt_id: MP:0001590
def: "deviation from normal for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [ISBN:0-683-40008-8, MGI:cwg]
comment: MCV is calculated by dividing the hematocrit by the total number of RBCs and multiplying this number by ten (10).
synonym: "abnormal MCV" EXACT []
synonym: "abnormal mean cell volume" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0000228
name: abnormal thrombopoiesis
alt_id: MP:0000211
alt_id: MP:0000227
alt_id: MP:0001583
alt_id: MP:0001591
alt_id: MP:0001592
alt_id: MP:0002448
def: "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MESH:G04.335.151.825.798]
synonym: "abnormal thrombocyte development" RELATED []
synonym: "abnormal thrombocyte differentiation" RELATED []
is_a: MP:0001601 ! abnormal myelopoiesis
is_a: MP:0004720 ! abnormal platelet morphology

[Term]
id: MP:0000229
name: abnormal megakaryocyte differentiation
alt_id: MP:0001593
def: "atypical production of or inability to produce the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm" [CL:0000556, ISBN:0721601464]
synonym: "abnormal megacaryocyte differentiation" EXACT []
synonym: "abnormal megalocaryocyte differentiation" EXACT []
synonym: "abnormal megalokaryocyte differentiation" EXACT []
is_a: MP:0002417 ! abnormal megakaryocyte morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0000230
name: abnormal systemic arterial blood pressure
alt_id: MP:0001594
alt_id: MP:0002129
def: "altered tension of the blood within the systemic arteries" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "heart/cardiovascular system: blood pressure anomalies" BROAD []
xref: MGI:2173589
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0000231
name: hypertension
alt_id: MP:0001595
def: "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [ISBN:0-683-40008-8]
is_a: MP:0002842 ! increased systemic arterial blood pressure

[Term]
id: MP:0000233
name: abnormal blood flow velocity
alt_id: MP:0001597
def: "any anomaly in the rate of flow of the blood through vessels" [MGI:cwg]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0000237
name: obsolete decreased blood cell number
def: "OBSOLETE.  fewer than the normal numbers of the various types of blood cells" [PMID:10673499]
synonym: "reduced blood cell number" EXACT []
synonym: "reduction in hematopoietic cell types" EXACT []
synonym: "reduction in hemopoietic cell types" EXACT []
is_obsolete: true
replaced_by: MP:0011182

[Term]
id: MP:0000238
name: absent pre-B cells
alt_id: MP:0000349
def: "absence of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [MGI:tc, PMID:10673499]
synonym: "Absence of pre-B cell" EXACT []
synonym: "absence of pre-B cell" EXACT []
synonym: "deficiency of pre-B cells" EXACT []
synonym: "Loss of pre-B cell" EXACT []
synonym: "loss of pre-B cell" EXACT []
is_a: MP:0008209 ! decreased pre-B cell number

[Term]
id: MP:0000239
name: absent common myeloid progenitor cells
def: "lack of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, PMID:10673499]
synonym: "absence of myeloid colony forming progenitor cells" EXACT []
synonym: "absent cfu-gemm" RELATED []
synonym: "absent CFU-S" RELATED []
synonym: "absent CMPs" EXACT []
synonym: "absent colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED []
synonym: "absent multipotential myeloid stem cell" RELATED []
synonym: "absent myeloid stem cell" RELATED []
synonym: "absent pluripotent stem cell (bone marrow)" RELATED []
synonym: "deficiency of myeloid colony forming progenitor cells" RELATED []
is_a: MP:0000172 ! abnormal bone marrow cell number
is_a: MP:0008813 ! decreased common myeloid progenitor cell number

[Term]
id: MP:0000240
name: extramedullary hematopoiesis
def: "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MESH:G04.335.151.825.463]
synonym: "EMH" EXACT []
synonym: "extramedullary haematopoiesis" EXACT []
synonym: "extramedullary haemopoiesis" EXACT []
synonym: "extramedullary hemopoiesis" EXACT []
synonym: "extramedullary myelopoiesis" NARROW []
is_a: MP:0002123 ! abnormal definitive hematopoiesis

[Term]
id: MP:0000242
name: impaired fertilization
def: "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei" [ISBN:0-683-40008-8]
is_a: MP:0005410 ! abnormal fertilization

[Term]
id: MP:0000243
name: myoclonus
def: "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [ISBN:0-683-40008-8, MESH:C10.597.350.500]
is_a: MP:0000743 ! muscle spasm
is_a: MP:0000947 ! convulsive seizures

[Term]
id: MP:0000245
name: abnormal erythropoiesis
alt_id: MP:0001608
def: "atypical process of the formation of enucleated fetal and adult erythrocytes" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal definitive erythropoiesis" EXACT []
synonym: "abnormal erythrocyte development" EXACT []
synonym: "abnormal erythrocytopoiesis" EXACT []
synonym: "erythropoiesis abnormalities" EXACT []
is_a: MP:0002123 ! abnormal definitive hematopoiesis
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0000247
name: obsolete abnormal interleukin-10 physiology
def: "OBSOLETE. functional anomaly of this factor that is a co-regulator of mast cell growth and produced by T and B cells" [https://orcid.org/0000-0002-0371-1954]
comment: This term is obsolete. Instead, use the terms abnormal circulating interleukin-10 level (MP:0008590) and its children or abnormal interleukin-10 secretion (MP:0008659) and its children.
synonym: "abnormal IL-10 physiology" EXACT []
is_obsolete: true
consider: MP:0008590
consider: MP:0008659

[Term]
id: MP:0000248
name: macrocytosis
alt_id: MP:0001610
def: "condition in which erythrocytes are larger than normal in size" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "macrocythemia" EXACT []
synonym: "megalocythemia" EXACT []
synonym: "megalocytosis" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0000249
name: abnormal blood vessel physiology
def: "any functional anomaly of any of the tubes that convey blood including the arteries, arterioles, capillaries, venules, and veins" [ISBN:0-683-40008-8]
synonym: "abnormal blood vessel function" EXACT []
synonym: "blood vessel defects" BROAD []
synonym: "blood vessel physiology abnormalities" EXACT []
is_a: MP:0031170 ! abnormal vasculature physiology

[Term]
id: MP:0000250
name: abnormal vasoconstriction
alt_id: MP:0001612
alt_id: MP:0005593
def: "anomaly in the narrowing of the blood vessels by smooth muscle contraction" [ISBN:0-683-40008-8, MESH:G09.330.582.400.920]
synonym: "abnormal vascular smooth muscle contraction" EXACT []
is_a: MP:0005595 ! abnormal vascular smooth muscle physiology
is_a: MP:0005620 ! abnormal muscle contractility

[Term]
id: MP:0000255
name: blood vessel congestion
def: "obstruction of the normal flux of blood within the blood vessel network" [ISBN:0-683-40008-8, MGI:tc]
synonym: "blood vasculature congestion" RELATED []
synonym: "congested blood vasculature" RELATED []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0000256
name: echinocytosis
def: "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:12594949]
synonym: "burr erythrocyte" EXACT []
synonym: "crenation" EXACT []
synonym: "echinosis" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0000259
name: abnormal vascular development
alt_id: MP:0001620
def: "aberrant process of vascular formation" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "vascular development abnormalities" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0002925 ! abnormal cardiovascular development

[Term]
id: MP:0000260
name: abnormal angiogenesis
alt_id: MP:0001621
def: "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "angiogenesis abnormalities" EXACT []
is_a: MP:0000259 ! abnormal vascular development

[Term]
id: MP:0000262
name: poor arterial differentiation
def: "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [ISBN:0-683-40008-8]
is_a: MP:0003410 ! abnormal artery development

[Term]
id: MP:0000263
name: absent organized vascular network
def: "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [PMID:9949198]
synonym: "absence of organized vascular network" EXACT []
is_a: MP:0001622 ! abnormal vasculogenesis

[Term]
id: MP:0000264
name: failure of vascular branching
def: "failure of vasculature to form divisions (offshoots)" [PMID:9949198]
is_a: MP:0003227 ! abnormal vascular branching morphogenesis

[Term]
id: MP:0000265
name: blood vessel atresia
def: "abnormal closure or absence of the lumen of one or more blood vessels" [ISBN:0-683-40008-8]
synonym: "atretic blood vasculature" RELATED []
synonym: "atretic blood vessel" EXACT []
synonym: "blood vasculature atresia" RELATED []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0000266
name: abnormal heart morphology
alt_id: MP:0000271
def: "any structural anomaly of the hollow, muscular organ that maintains the circulation of the blood" [MESH:A07.541, PMID:7477375]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC_Prenatal
synonym: "abnormal cardiac morphology" EXACT []
synonym: "abnormal heart" BROAD []
synonym: "cardiac abnormalities" BROAD []
synonym: "cardiac defects" BROAD []
synonym: "cardiac dysplasia" NARROW []
synonym: "heart abnormalities" BROAD []
synonym: "heart defects" BROAD []
xref: GO:0007505
is_a: MP:0002127 ! abnormal cardiovascular system morphology

[Term]
id: MP:0000267
name: abnormal heart development
alt_id: MP:0001624
def: "aberrant formation or incomplete differentiation of the heart" [https://orcid.org/0000-0003-3691-0324, PMID:9949198]
subset: IMPC_Prenatal
synonym: "abnormal cardiac development" EXACT []
synonym: "cardiac development abnormalities" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0002925 ! abnormal cardiovascular development

[Term]
id: MP:0000268
name: obsolete abnormal anterior cardiac development
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiac development, anterior" EXACT []
synonym: "cardiac development abnormalities, anterior" EXACT []
is_obsolete: true

[Term]
id: MP:0000269
name: abnormal heart looping
def: "any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration" [GO:0001947]
synonym: "abnormal cardiac looping" EXACT []
synonym: "abnormal looping morphogenesis" BROAD []
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0000270
name: abnormal heart tube morphology
def: "any structural anomaly of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [ISBN:0-683-40008-8]
synonym: "abnormal cardiac tube morphology" EXACT []
synonym: "abnormal primitive heart morphology" EXACT []
synonym: "heart tube abnormalities" BROAD []
synonym: "heart tube dysplasia" NARROW []
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0000272
name: abnormal aorta morphology
def: "any structural anomaly of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries" [ISBN:0-683-40008-8, MESH:A07.231.114.056]
subset: CvDC_Terms
synonym: "abnormal aortae morphology" EXACT []
synonym: "aorta abnormalities" BROAD []
synonym: "aorta dysplasia" NARROW []
xref: Fyler:1453
xref: MA:0000062
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0000273
name: overriding aortic valve
def: "congenitally abnormal position of the aorta where the valve origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left, frequently in conjunction with a ventricular septal defect" [ISBN:0-683-40008-8, MGI:cml]
subset: CvDC_Terms
synonym: "aortic dextroposition" EXACT []
synonym: "DA" EXACT []
synonym: "dextroposition of the aorta" EXACT []
synonym: "overriding aorta" EXACT []
xref: Fyler:1432
is_a: MP:0010426 ! abnormal heart and great artery attachment

[Term]
id: MP:0000274
name: enlarged heart
def: "increase over normal size of the heart" [PMID:7477375]
synonym: "cardiomegaly" EXACT []
synonym: "increased heart size" EXACT []
synonym: "macrocardia" EXACT []
synonym: "megacardia" EXACT []
synonym: "megalocardia" EXACT []
is_a: MP:0005406 ! abnormal heart size
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0000275
name: heart hyperplasia
def: "increase in the number of normal cells in normal arrangement in the heart, typically resulting in increased size" [PMID:7926784]
synonym: "hyperplastic heart" EXACT []
is_a: MP:0000274 ! enlarged heart

[Term]
id: MP:0000276
name: heart right ventricle hypertrophy
def: "enlargement of heart right ventricular wall and septum from the increase in size of its cells" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "hypertrophic right ventricle" EXACT []
synonym: "right ventricle hypertrophy" EXACT []
synonym: "right ventricular hypertrophy" EXACT []
xref: Fyler:3609
is_a: MP:0001625 ! cardiac hypertrophy
is_a: MP:0010563 ! increased heart right ventricle size
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
is_a: MP:0031534 ! abnormal heart right ventricle wall morphology

[Term]
id: MP:0000277
name: abnormal heart shape
def: "any anomaly in the characteristic surface outline or contour of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "heart shape abnormalities" EXACT []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0000278
name: abnormal myocardial fiber morphology
alt_id: MP:0002994
def: "any structural anomaly of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [PMID:7926784]
synonym: "abnormal adult cardiomyocyte morphology" EXACT []
synonym: "abnormal cardiac muscle cell morphology" EXACT []
synonym: "abnormal myocardial cell morphology" EXACT []
synonym: "abnormal myocardial fibers" BROAD []
synonym: "abnormal myocardial fibre morphology" EXACT []
synonym: "abnormal myocardial fibres" BROAD []
synonym: "myocardial fiber dysplasia" NARROW []
synonym: "myocardial fibers abnormalities" BROAD []
synonym: "myocardial fibre dysplasia" NARROW []
synonym: "myocardial fibres abnormalities" BROAD []
is_a: MP:0004087 ! abnormal muscle fiber morphology
is_a: MP:0005329 ! abnormal myocardium layer morphology

[Term]
id: MP:0000279
name: ventricular hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart ventricle, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplasia of ventriculum" EXACT []
synonym: "hypoplastic ventriculum" EXACT []
is_a: MP:0002188 ! small heart
is_a: MP:0005294 ! abnormal heart ventricle morphology

[Term]
id: MP:0000280
name: thin ventricular wall
def: "decreased depth of the cardiac wall of the heart ventricles" [PMID:9362461]
is_a: MP:0020135 ! abnormal heart ventricle wall thickness

[Term]
id: MP:0000281
name: abnormal interventricular septum morphology
alt_id: MP:0005484
def: "any structural anomaly of the wall between the two lower chambers of the heart; the ventricular septum consists of a very small membranous portion just beneath the aortic valve, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum" [MESH:A07.541.459.750]
subset: CvDC_Terms
synonym: "abnormal ventricular septum morphology" EXACT []
synonym: "interventricular septum dysplasia" NARROW []
synonym: "ventricular septum dysplasia" NARROW []
xref: Fyler:1815
is_a: MP:0005294 ! abnormal heart ventricle morphology
is_a: MP:0006113 ! abnormal heart septum morphology

[Term]
id: MP:0000282
name: abnormal interatrial septum morphology
def: "any structural anomaly of the thin membranous structure between the two heart atria" [MESH:A07.541.459]
subset: CvDC_Terms
synonym: "abnormal atrial septum morphology" EXACT []
synonym: "atrial septum dysplasia" NARROW []
synonym: "interatrial septum dysplasia" NARROW []
xref: Fyler:2002
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0006113 ! abnormal heart septum morphology

[Term]
id: MP:0000284
name: double outlet right ventricle
alt_id: MP:0000283
def: "both the aorta and the pulmonary trunk originate, either in whole or in part, from the right ventricle; often found in conjunction with a ventricular septal defect" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "dextraposed ascending aorta" EXACT []
synonym: "DORV" EXACT []
synonym: "double outlet heart right ventricle" EXACT []
synonym: "double-outflow right ventricle" EXACT []
xref: Fyler:0600
xref: Fyler:600
is_a: MP:0010426 ! abnormal heart and great artery attachment

[Term]
id: MP:0000285
name: abnormal heart valve morphology
def: "any structural anomaly of the membranous folds of the heart that prevent reflux of fluid" [MESH:A07.541.510, PMID:7926784]
synonym: "abnormal cardiac valve morphology" EXACT []
synonym: "cardiac valve dysplasia" NARROW []
synonym: "heart valve dysplasia" NARROW []
synonym: "valve abnormalities" BROAD []
synonym: "valve defects" BROAD []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0000286
name: abnormal mitral valve morphology
def: "any structural anomaly of the valve that is located between the left atrium and the left ventricle of the heart, and contains two cusps, the anterior cusp and the posterior cusp, attached to the outer fibrous ring (annulus)" [ISBN:0-683-40008-8, MESH:A07.541.510.507, PMID:9949198]
subset: CvDC_Terms
synonym: "abnormal bicuspid valve morphology" EXACT []
synonym: "abnormal left atrioventricular valve morphology" EXACT []
synonym: "abnormal left AV valve morphology" EXACT []
synonym: "abnormal mitral valvar morphology" EXACT []
synonym: "mitral valve dysplasia" NARROW []
xref: Fyler:1508
is_a: MP:0002745 ! abnormal atrioventricular valve morphology

[Term]
id: MP:0000287
name: heart valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in any of the heart valves, typically resulting in decreased size" [PMID:9362461]
synonym: "hypoplastic heart valves" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology

[Term]
id: MP:0000288
name: abnormal pericardium morphology
def: "any structural anomaly of the fibroserous membrane covering the heart and beginning of the great vessels" [ISBN:0-683-40008-8, MGI:cml, PMID:10072433]
subset: CvDC_Terms
subset: IMPC_Prenatal
synonym: "abnormal pericaridal sac morphology" EXACT []
synonym: "pericardial abnormalities" BROAD []
synonym: "pericardium dysplasia" NARROW []
xref: Fyler:1900
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0000291
name: enlarged pericardium
def: "extended fibroserous membrane covering the heart and beginning of the great vessels" [PMID:7477375]
synonym: "enlarged pericardial sac" EXACT []
synonym: "increased pericardium size" EXACT []
is_a: MP:0000288 ! abnormal pericardium morphology

[Term]
id: MP:0000292
name: distended pericardium
def: "an expansion in the volume of the sac-like structure contained by the outer parietal layer of the pericardium" [https://orcid.org/0000-0003-3691-0324]
synonym: "distended pericardial sacs" EXACT []
is_a: MP:0000288 ! abnormal pericardium morphology

[Term]
id: MP:0000293
name: absent myocardial trabeculae
alt_id: MP:0000294
def: "absence of the supporting bundles of muscular fibers lining the walls of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of trabeculae" EXACT []
synonym: "absent trabeculae" EXACT []
synonym: "failure of myocardial trabecular formation" EXACT []
synonym: "failure of trabecular formation" EXACT []
is_a: MP:0002189 ! abnormal myocardial trabeculae morphology

[Term]
id: MP:0000295
name: trabecula carnea hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the supporting bundles of muscular fibers lining the walls of the ventricles of the heart, typically resulting in decreased size" [PMID:7477375]
subset: CvDC_Terms
synonym: "hypoplastic trabecula carnea" EXACT []
synonym: "poorly developed trabecula carnea" EXACT []
synonym: "poorly developed ventricular trabeculae" EXACT []
is_a: MP:0004067 ! abnormal trabecula carnea morphology
is_a: MP:0010502 ! ventricle myocardium hypoplasia
is_a: MP:0010503 ! myocardial trabeculae hypoplasia

[Term]
id: MP:0000296
name: absent trabeculae carneae
def: "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [PMID:9362461]
synonym: "absence of ventricular trabeculae" EXACT []
synonym: "absent columnae carneae" EXACT []
synonym: "absent fleshy beams" EXACT []
synonym: "absent Rathke bundles" EXACT []
synonym: "absent ventricular trabeculae" EXACT []
is_a: MP:0000293 ! absent myocardial trabeculae
is_a: MP:0004067 ! abnormal trabecula carnea morphology

[Term]
id: MP:0000297
name: abnormal atrioventricular cushion morphology
def: "any structural anomaly of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices and the atrioventricular septum" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal endocardial cushion" BROAD []
synonym: "abnormal endocardial cushion morphology" BROAD []
synonym: "atrioventricular cushion dysplasia" NARROW []
synonym: "endocardial cushion abnormalities" BROAD []
xref: GO:0007505
is_a: MP:0006107 ! abnormal fetal atrioventricular canal morphology

[Term]
id: MP:0000298
name: absent atrioventricular cushions
def: "absence of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of endocardial cushion" BROAD []
synonym: "absent endocardial cushion" BROAD []
is_a: MP:0000297 ! abnormal atrioventricular cushion morphology

[Term]
id: MP:0000299
name: failure of atrioventricular cushion closure
def: "failure of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [PMID:7477375]
synonym: "atrioventricular cushion closure failure" EXACT []
synonym: "failure of endocardial cushion closure" EXACT []
synonym: "failure of endocardial cushion fusion" EXACT []
synonym: "failure of endocardial cushions to fuse" EXACT []
is_a: MP:0000297 ! abnormal atrioventricular cushion morphology
is_a: MP:0010599 ! abnormal fetal atrioventricular canal septation

[Term]
id: MP:0000300
name: thin atrioventricular cushion
def: "reduced thickness of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal" [PMID:9362461]
synonym: "thin endocardial cushions" BROAD []
is_a: MP:0000301 ! decreased atrioventricular cushion size

[Term]
id: MP:0000301
name: decreased atrioventricular cushion size
def: "smaller than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal" [ISBN:0-683-40008-8, PMID:7477377]
synonym: "decreased endocardial cushion size" BROAD []
synonym: "decreased size of endocardial cushions" BROAD []
synonym: "reduced atrioventricular cushion size" EXACT []
synonym: "reduced endocardial cushion size" BROAD []
synonym: "reduced size of endocardial cushions" BROAD []
is_a: MP:0000297 ! abnormal atrioventricular cushion morphology

[Term]
id: MP:0000304
name: abnormal cardiac stroke volume
alt_id: MP:0001628
def: "anomaly in the volume of blood pushed into the aorta with each beat of the heart" [MESH:E01.370.370.380.150.700, MGI:cwg]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0000306
name: obsolete abnormal pulse
alt_id: MP:0001630
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0004085

[Term]
id: MP:0000307
name: obsolete abnormal heart sounds
alt_id: MP:0001631
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000313
name: abnormal cell death
alt_id: MP:0001647
def: "any anomaly in the cessation of function at the cellular level" [ISBN:0-683-40008-8]
synonym: "abnormal cell viability" EXACT []
synonym: "abnormal cellular death" EXACT []
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0000314
name: schistocytosis
def: "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [https://orcid.org/0000-0002-6490-7723, PMID:12594949]
synonym: "fragmented erythrocytes" EXACT []
synonym: "fragmented red blood cells" RELATED []
synonym: "schizocytosis" EXACT []
is_a: MP:0002643 ! poikilocytosis

[Term]
id: MP:0000315
name: hemoglobinuria
def: "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [https://orcid.org/0000-0002-6490-7723, PMID:12594949]
synonym: "haemoglobinuria" EXACT []
synonym: "increased urine haemoglobin level" EXACT []
synonym: "increased urine hemoglobin level" EXACT []
is_a: MP:0002962 ! increased urine protein level

[Term]
id: MP:0000316
name: cellular necrosis
def: "pathologic death of cells, usually from irreversible damage" [ISBN:0-683-40008-8]
synonym: "necrotic cell" EXACT []
synonym: "necrotic cells" EXACT []
is_a: MP:0000313 ! abnormal cell death

[Term]
id: MP:0000317
name: obsolete abnormal cell number
def: "OBSOLETE. any anomaly in the numbers of cells" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0000318
name: obsolete increased cell number
def: "OBSOLETE. greater than expected number of cells" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0000319
name: obsolete increased activated B cell number
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "increased activated B-cell number" EXACT []
is_obsolete: true

[Term]
id: MP:0000321
name: increased bone marrow cell number
alt_id: MP:0000173
def: "increased number of cells that make up the core cavities of bones when compared to the normal state" [MGI:tc]
synonym: "bone marrow hypercellularity" EXACT []
synonym: "bone marrow hyperplasia" NARROW []
synonym: "hypercellular bone marrow" EXACT []
synonym: "hyperplastic bone marrow" NARROW []
synonym: "increased bone marrow cellularity" EXACT []
is_a: MP:0000172 ! abnormal bone marrow cell number

[Term]
id: MP:0000322
name: increased granulocyte number
alt_id: MP:0000719
def: "greater than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "granulocytosis" EXACT []
is_a: MP:0000218 ! increased leukocyte cell number
is_a: MP:0020201 ! abnormal granulocyte number

[Term]
id: MP:0000324
name: increased mast cell number
def: "greater than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation" [MESH:A.11.329.427]
synonym: "mastocytosis" EXACT []
is_a: MP:0000322 ! increased granulocyte number
is_a: MP:0020203 ! abnormal mast cell number

[Term]
id: MP:0000327
name: hemosiderinuria
def: "the presence of hemosiderin in the urine; hemosiderin is an intracellular storage form of iron, found in the form of pigmented yellow to brown granules consisting of a complex of ferric hydroxides, polysaccharides, and proteins with an iron content of about 33 per cent by weight" [https://orcid.org/0000-0002-6490-7723, PMID:12594949]
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0000328
name: increased enterocyte cell number
def: "greater than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584]
synonym: "increased enterocyte number" EXACT []
synonym: "increased intestinal cell number" BROAD []
is_a: MP:0000481 ! abnormal enterocyte cell number

[Term]
id: MP:0000329
name: obsolete decreased cell number
def: "OBSOLETE. fewer than expected number of cells" [MGI:cwg]
synonym: "reduced cell number" EXACT []
is_obsolete: true

[Term]
id: MP:0000330
name: obsolete decreased activated B cell number
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased activated B lymphocyte number" EXACT []
synonym: "decreased activated B-cell number" EXACT []
is_obsolete: true

[Term]
id: MP:0000332
name: hemoglobinemia
def: "the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis" [https://orcid.org/0000-0002-6490-7723, PMID:12594949]
synonym: "haemoglobinaemia" EXACT []
synonym: "haemoglobinemia" EXACT []
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0000333
name: decreased bone marrow cell number
alt_id: MP:0000174
def: "decreased number of cells that make up the core cavities of bones when compared to the normal state" [MGI:tc, PMID:10716451]
synonym: "bone marrow hypocellularity" EXACT []
synonym: "bone marrow hypoplasia" NARROW []
synonym: "decreased bone marrow cellularity" EXACT []
synonym: "hypocellular bone marrow" EXACT []
synonym: "hypoplastic bone marrow" NARROW []
synonym: "reduced bone marrow cell number" EXACT []
synonym: "reduced bone marrow cellularity" EXACT []
is_a: MP:0000172 ! abnormal bone marrow cell number

[Term]
id: MP:0000334
name: decreased granulocyte number
alt_id: MP:0000723
def: "fewer than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "agranulocytosis" NARROW []
synonym: "granulocytopenia" NARROW []
synonym: "reduced granulocyte number" EXACT []
is_a: MP:0000221 ! decreased leukocyte cell number
is_a: MP:0020201 ! abnormal granulocyte number

[Term]
id: MP:0000336
name: decreased mast cell number
def: "fewer than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation" [MESH:A.11.329.427]
synonym: "reduced mast cell number" EXACT []
is_a: MP:0000334 ! decreased granulocyte number
is_a: MP:0020203 ! abnormal mast cell number

[Term]
id: MP:0000339
name: decreased enterocyte cell number
def: "fewer than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584]
synonym: "decreased intestinal cell number" BROAD []
synonym: "reduced enterocyte number" EXACT []
synonym: "reduced intestinal cell number" BROAD []
is_a: MP:0000481 ! abnormal enterocyte cell number

[Term]
id: MP:0000340
name: obsolete absence of cell
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "loss of cell" EXACT []
is_obsolete: true

[Term]
id: MP:0000341
name: abnormal bile color
def: "any change in the color of the bile from the normal yellowish brown or green" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal bile colour" EXACT []
is_a: MP:0005085 ! abnormal gallbladder physiology

[Term]
id: MP:0000343
name: abnormal response to cardiac infarction
def: "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [ISBN:0-683-40008-8, MESH:C14.280.647.500]
synonym: "altered response to cardiac infarction" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0000344
name: absent Cajal-Retzius cell
alt_id: MP:0000793
alt_id: MP:0000817
def: "the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:tc, PMID:10716451]
synonym: "absence of Cajal-Retzius cell" EXACT []
synonym: "loss of Cajal-Retzius cell" BROAD []
is_a: MP:0008031 ! decreased Cajal-Retzius cell number

[Term]
id: MP:0000346
name: broad head
def: "a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011495 ! abnormal head shape

[Term]
id: MP:0000348
name: abnormal aerobic fitness
def: "any change in the metabolism resulting in an altered ability to do physical work; for example, alterations in running capacity" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0000350
name: abnormal cell proliferation
def: "anomaly in the ability of a cell population to undergo expansion by cell division" [ISBN:0-683-40008-8]
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0000351
name: increased cell proliferation
def: "increase in the expansion rate of a cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation

[Term]
id: MP:0000352
name: decreased cell proliferation
def: "reduction in the expansion rate of a cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation

[Term]
id: MP:0000353
name: obsolete Abnormal Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000354
name: obsolete Increased Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000355
name: obsolete Increased Purkinje Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000356
name: obsolete Decreased Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000357
name: obsolete Decreased Purkinje Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000358
name: abnormal cell morphology
alt_id: MP:0000311
alt_id: MP:0000312
def: "any structural anomaly of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [MESH:A11, MGI:cwg]
synonym: "abnormal cell" BROAD []
synonym: "abnormal cell content" NARROW []
synonym: "abnormal cell content or morphology" EXACT []
synonym: "cell abnormalities" BROAD []
synonym: "cellular abnormalities" BROAD []
is_a: MP:0005384 ! cellular phenotype

[Term]
id: MP:0000359
name: abnormal mast cell morphology
def: "any structural anomaly of a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation" [ISBN:068340007X, MESH:A.11.329.427]
is_a: MP:0002441 ! abnormal granulocyte morphology

[Term]
id: MP:0000360
name: obsolete absent metachromatic granules
def: "OBSOLETE. lack of intracellular storage compartments that stain a different color than that of the dye used" [ISBN:0-683-40008-8, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0000361
name: decreased mast cell protease storage
def: "reduced amounts of proteolytic enzymes stored in mast cells" [MGI:cwg]
synonym: "reduced mast cell protease storage" EXACT []
synonym: "reduced storage of mast-cell proteases" EXACT []
is_a: MP:0000359 ! abnormal mast cell morphology

[Term]
id: MP:0000362
name: decreased mast cell histamine storage
def: "reduced amounts of histamine stored in mast cells" [MGI:cwg]
synonym: "decreased histamine storage" BROAD []
synonym: "reduced histamine storage" BROAD []
synonym: "reduced mast cell histamine storage" EXACT []
synonym: "reduced storage of histamine" BROAD []
is_a: MP:0000359 ! abnormal mast cell morphology

[Term]
id: MP:0000363
name: obsolete Abnormal Cell Behavior
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000364
name: abnormal vascular regression
def: "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal apoptosis involved in patterning of blood vessels" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0009577 ! abnormal developmental vascular remodeling

[Term]
id: MP:0000365
name: obsolete Abnormal Hematopoietic/Hemopoietic/ Hematogenic/Hemogenic/Sanguifacient Cell Behavior
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000366
name: obsolete Impaired Proliferative Response of Hematopoietic Cells to Mitogens
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000367
name: abnormal coat/ hair morphology
def: "any anomaly in the color, structure, growth, or texture of the hair" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal coat/ hair" BROAD []
synonym: "abnormal pelage morphology" EXACT []
synonym: "coat/ hair abnormalities" BROAD []
synonym: "coat/ hair anomalies" BROAD []
is_a: MP:0010678 ! abnormal skin adnexa morphology

[Term]
id: MP:0000370
name: head blaze
def: "the appearance of a stripe of white fur on the head" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0000371
name: diluted coat color
def: "a coat color that appears lighter in intensity or paler than normal" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "dilute coat" EXACT []
synonym: "diluted coat colour" EXACT []
synonym: "light coat color" EXACT []
synonym: "light coat colour" EXACT []
synonym: "pale coat color" EXACT []
synonym: "pale coat colour" EXACT []
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0000372
name: irregular coat pigmentation
def: "uneven coloration of the hair" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0000373
name: belly spot
def: "the appearance of a round area of white fur on the belly" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002938 ! white spotting

[Term]
id: MP:0000374
name: obsolete pink fur hue
def: "OBSOLETE. hairs have a prominent pink tinge" [PMID:10769039]
is_obsolete: true

[Term]
id: MP:0000376
name: folliculitis
def: "inflammatory reaction in hair follicles" [ISBN:0-683-40008-8, PMID:8941642]
is_a: MP:0000377 ! abnormal hair follicle morphology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0000377
name: abnormal hair follicle morphology
alt_id: MP:0000375
def: "any structural anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500]
synonym: "abnormal hair follicle structure" EXACT []
synonym: "abnormal hair follicles" BROAD []
synonym: "hair follicle dysplasia" NARROW []
synonym: "hair follicle structure abnormalities" EXACT []
synonym: "hair follicles abnormalities" BROAD []
is_a: MP:0030572 ! abnormal pilosebaceous unit morphology

[Term]
id: MP:0000378
name: absent hair follicles
def: "missing epidermal invaginations from which the hair shaft develops" [MESH:A10.272.497.500]
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000379
name: decreased hair follicle number
def: "fewer number of the epidermal invaginations from which the hair shaft develops" [MESH:A10.272.497.500]
synonym: "reduced hair follicle number" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000380
name: small hair follicles
def: "reduced size of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, PMID:10469309]
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000381
name: enlarged hair follicles
def: "increased size of the epidermal invaginations from which the hair shaft develops" [MESH:A10.272.497.500]
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000382
name: underdeveloped hair follicles
def: "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [ISBN:0-683-40008-8, MESH:A10.272.497.500]
is_a: MP:0003704 ! abnormal hair follicle development

[Term]
id: MP:0000383
name: abnormal hair follicle orientation
def: "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [PMID:9573048]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000384
name: distorted hair follicle pattern
def: "twisted or contorted configuration of the arrangement of hair follicles in the skin" [PMID:10469309]
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0000385
name: obsolete distended hair follicles
def: "OBSOLETE. follicles that have swollen or expanded from the skin" [J:53379]
is_obsolete: true
replaced_by: MP:0010699

[Term]
id: MP:0000386
name: obsolete abnormal hair follicle root sheath
def: "OBSOLETE. anomalies of the epidermal-derived layer surrounding the hair follicle; innermost of two layers" [MGI:cwg]
comment: Obsolete. Use either abnormal hair follicle outer root sheath morphology (MP:0010684) or abnormal hair follicle inner root sheath morphology (MP:0010685).
synonym: "hair follicle root sheath abnormalities" EXACT []
is_obsolete: true
consider: MP:0010684
consider: MP:0010685

[Term]
id: MP:0000387
name: disorganized inner root sheath cells
def: "disorganization of the epithelial cells that resides in the inner root sheath of the hair follicle" [CL:0002560]
synonym: "disorganised inner root sheath cells" EXACT []
is_a: MP:0010685 ! abnormal hair follicle inner root sheath morphology

[Term]
id: MP:0000388
name: absent hair follicle inner root sheath
def: "absence of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle" [PMID:19211055]
synonym: "absent inner root sheath" RELATED []
is_a: MP:0010685 ! abnormal hair follicle inner root sheath morphology

[Term]
id: MP:0000389
name: disorganized outer root sheath cells
def: "disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis" [PMID:10469309]
synonym: "disorganised outer root sheath cells" EXACT []
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology

[Term]
id: MP:0000390
name: disorganized matrix sheath cells
def: "disordered layer of matrix cells of the hair follicle" [PMID:10469309]
synonym: "disorganised matrix sheath cells" EXACT []
is_a: MP:0010686 ! abnormal hair follicle matrix region morphology

[Term]
id: MP:0000391
name: premature hair follicle generation
def: "early onset of hair follicle development" [PMID:9135074]
is_a: MP:0003704 ! abnormal hair follicle development

[Term]
id: MP:0000392
name: accelerated hair follicle regression
def: "earlier onset of catagen phase during the cyclic transformation of the hair follicle" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0003875 ! abnormal hair follicle regression

[Term]
id: MP:0000393
name: persistent hair follicle morphogenesis
def: "continuous induction of de novo hair follicles in the epidermis" [J:51296]
is_a: MP:0003704 ! abnormal hair follicle development

[Term]
id: MP:0000394
name: absent hair follicle melanin granules
def: "absence of the pigment polymers located in the hair follicles" [MGI:llw2]
synonym: "absence of melanin granules in hair follicle" EXACT []
synonym: "absent melanin granules in hair follicle" EXACT []
is_a: MP:0005072 ! abnormal hair follicle melanin granule morphology

[Term]
id: MP:0000395
name: obsolete abnormal hair types
def: "OBSOLETE. any structural anomaly of the different subsets of types of hairs or change to the expected complement of different hair types" [PMID:9573048]
is_obsolete: true
consider: MP:0000367
consider: MP:0000397
consider: MP:0000400
consider: MP:0000402
consider: MP:0000405

[Term]
id: MP:0000396
name: increased curvature of hairs
def: "greater bending arch of the distinct C- or S- shaped curvature of the hairs" [J:4606]
is_a: MP:0003809 ! abnormal hair shaft morphology

[Term]
id: MP:0000397
name: abnormal guard hair morphology
def: "any structural anomaly of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2]
synonym: "abnormal monotrich hair morphology" EXACT []
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0000398
name: splitting of guard hairs
def: "intercellular splits and kinks within or along the hair shaft of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2, PMID:9808631]
synonym: "splitting of monotrich hair" EXACT []
is_a: MP:0000397 ! abnormal guard hair morphology

[Term]
id: MP:0000399
name: increased curvature of guard hairs
def: "greater bending arch of the guard hairs" [PMID:9573048]
synonym: "increased curvature of monotrich hair" EXACT []
is_a: MP:0000396 ! increased curvature of hairs
is_a: MP:0000397 ! abnormal guard hair morphology

[Term]
id: MP:0000400
name: abnormal awl hair morphology
def: "any structural anomaly of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2]
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0000401
name: increased curvature of awl hairs
def: "greater bending arch of the awl hairs" [PMID:9573048]
is_a: MP:0000396 ! increased curvature of hairs
is_a: MP:0000400 ! abnormal awl hair morphology

[Term]
id: MP:0000402
name: abnormal zigzag hair morphology
def: "any structural anomaly or amount of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2]
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0000403
name: increased curvature of zigzag hairs
def: "greater bending arch of the zigzag hairs" [PMID:9573048]
is_a: MP:0000396 ! increased curvature of hairs
is_a: MP:0000402 ! abnormal zigzag hair morphology

[Term]
id: MP:0000404
name: decreased curvature of zigzag hairs
def: "smaller bending arch of the zigzag hairs" [PMID:10804183]
synonym: "reduced curvature of zigzag hairs" EXACT []
is_a: MP:0000402 ! abnormal zigzag hair morphology

[Term]
id: MP:0000405
name: abnormal auchene hair morphology
def: "any structural anomaly of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla" [https://orcid.org/0000-0003-3691-0324, ISBN:0-8493-8372-2]
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0000406
name: increased curvature of auchene hairs
def: "greater bending arch of the auchene hairs" [PMID:9573048]
is_a: MP:0000396 ! increased curvature of hairs
is_a: MP:0000405 ! abnormal auchene hair morphology

[Term]
id: MP:0000407
name: abnormal duvet hair morphology
def: "any structural anomaly of the fine under hair of the coat" [MGI:cwg]
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0000408
name: absent duvet hair
def: "absence of the of the fine under hair of the coat" [MGI:cwg]
synonym: "absence of duvet hair" EXACT []
is_a: MP:0000407 ! abnormal duvet hair morphology

[Term]
id: MP:0000410
name: waved hair
def: "hair or fur having undulations or a sinusoidal shape" [PMID:9573048]
subset: IMPC
subset: Sanger_Terms
synonym: "curly hair" EXACT []
synonym: "waved fur" EXACT []
synonym: "wavy hair" EXACT []
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0000411
name: shiny fur
def: "fur with a glossy or glistening appearance" [J:45065]
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0000412
name: excessive hair
def: "greater amount of body hair compared to controls" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypertrichosis" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000413
name: polyphalangy
def: "increased number of phalanges in any of the digits" [https://orcid.org/0000-0003-3691-0324, J:13069]
is_a: MP:0005306 ! abnormal phalanx morphology

[Term]
id: MP:0000414
name: alopecia
def: "absence of hair due to loss of hair; not in reference to primary genetic hairlessness but may be due to dietary, stress or secondary to immune condition" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "absence of hair" BROAD []
synonym: "absence of hair shaft" BROAD []
synonym: "absent hair shaft" BROAD []
synonym: "baldness" EXACT []
synonym: "hair loss" EXACT []
synonym: "hairless" RELATED []
synonym: "loss of hair" EXACT []
synonym: "no hair shaft" BROAD []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000416
name: sparse hair
alt_id: MP:0000415
def: "body hair that is less dense; may be due to reduced follicle numbers or due to the inability to retain some of the hairs of the coat over time" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypotrichosis" BROAD []
synonym: "partial hair loss" RELATED []
synonym: "sparse fur" EXACT []
synonym: "thin coat" EXACT []
synonym: "thin hair" RELATED []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000417
name: short hair
def: "reduced average length of the hairs" [J:64948]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased hair length" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000418
name: focal hair loss
alt_id: MP:0006368
def: "focal absence of hair in areas where hair is normally expected; in rodents, often appearing behind the ears and on the tail, resulting in visible patches of skin and uneven spots of hair growth on the body" [ISBN:0-8493-8372-2]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "localized bare skin" RELATED []
synonym: "localized hair loss" RELATED []
synonym: "patchy fur" EXACT []
synonym: "patchy hair" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000419
name: obsolete rough hair
def: "OBSOLETE. greasy, matted appearance of the fur" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000420
name: ruffled hair
def: "fuzzy, irregular appearance of the hair" [J:50844]
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0000421
name: mottled coat
def: "coat has spots, streaks, and/or blotches of a different color" [J:17194]
synonym: "mottled fur" EXACT []
is_a: MP:0005366 ! variegated coat color

[Term]
id: MP:0000422
name: delayed hair appearance
def: "late onset of the first appearance of the fur" [J:17792]
synonym: "delayed hair growth" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000423
name: delayed hair regrowth
def: "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase" [PMID:10742104]
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0000424
name: retarded hair growth
def: "slow growth of the hair, appears at normal time" [J:5476]
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000425
name: loss of eyelid cilia
def: "inability to retain the eyelashes" [PMID:9420327]
synonym: "ciliary madarosis" EXACT []
synonym: "loss of cilia" BROAD []
synonym: "loss of eyelashes" EXACT []
synonym: "madarosis" EXACT []
synonym: "milphosis" EXACT []
is_a: MP:0002073 ! abnormal hair growth
is_a: MP:0013895 ! abnormal eyelid cilium morphology

[Term]
id: MP:0000426
name: ectopic hair growth
def: "positional abnormality of hair" [J:24350]
synonym: "heterotopic hair growth" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0000427
name: abnormal hair cycle
def: "aberrant timing of growth and regression of the hair follicles" [https://orcid.org/0000-0002-8404-2907, MGI:llw2]
is_a: MP:0010680 ! abnormal skin adnexa physiology

[Term]
id: MP:0000428
name: abnormal craniofacial morphology
def: "any structural anomaly of the face or head affecting appearance" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "craniofacial abnormalities" BROAD []
synonym: "craniofacial defects" BROAD []
synonym: "craniofacial dysplasia" NARROW []
is_a: MP:0005382 ! craniofacial phenotype

[Term]
id: MP:0000430
name: absent maxillary shelf
alt_id: MP:0000112
def: "missing bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:7914451]
synonym: "absent maxillary palatal process" EXACT []
synonym: "absent palatal process of maxilla" EXACT []
synonym: "absent palatine process" EXACT []
is_a: MP:0004538 ! abnormal maxillary shelf morphology

[Term]
id: MP:0000431
name: absent palatine bone horizontal plate
alt_id: MP:0000113
def: "missing bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:7914451]
synonym: "absent horizontal plate" EXACT []
synonym: "absent palatal process of palatine bone" EXACT []
synonym: "absent palatine palatal process" EXACT []
synonym: "absent palatine shelf" EXACT []
is_a: MP:0004537 ! abnormal palatine bone horizontal plate morphology

[Term]
id: MP:0000432
name: abnormal head morphology
def: "any structural anomaly of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "head abnormalities" BROAD []
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0000433
name: microcephaly
def: "an abnormally small head" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "decreased head size" EXACT []
synonym: "reduced head size" EXACT []
synonym: "small head" EXACT []
xref: Fyler:4310
is_a: MP:0011496 ! abnormal head size

[Term]
id: MP:0000434
name: megacephaly
alt_id: MP:0001266
def: "an abnormally large size of the head" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "big head" EXACT []
synonym: "enlarged head" EXACT []
synonym: "increased head size" EXACT []
synonym: "large head" EXACT []
synonym: "macrocephaly" EXACT []
xref: Fyler:4335
is_a: MP:0011496 ! abnormal head size

[Term]
id: MP:0000435
name: shortened head
def: "reduced anterior-posterior length of the head" [PMID:9256350]
subset: Europhenome_Terms
subset: IMPC
synonym: "brachycephaly" RELATED []
is_a: MP:0011495 ! abnormal head shape

[Term]
id: MP:0000436
name: abnormal head movements
alt_id: MP:0001390
def: "any anomaly in the motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal head movement" EXACT []
is_a: MP:0001388 ! abnormal stationary movement

[Term]
id: MP:0000437
name: taut facial appearance
def: "skin of face has appearance of being drawn or pulled tightly" [PMID:10769039]
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0000438
name: abnormal cranium morphology
def: "any structural anomaly of the bones of the head" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cranium" BROAD []
synonym: "abnormal skull" RELATED []
synonym: "abnormal skull morphology" RELATED []
synonym: "cranial abnormalities" BROAD []
synonym: "cranium dysplasia" NARROW []
synonym: "skull abnormalities" RELATED []
synonym: "skull anomaly" RELATED []
synonym: "skull anomaly, congenital" BROAD []
xref: Fyler:4134
xref: MA:0000316
is_a: MP:0002116 ! abnormal craniofacial bone morphology

[Term]
id: MP:0000439
name: enlarged cranium
def: "increased size of the cranium" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged skull" RELATED []
synonym: "increased cranium size" EXACT []
synonym: "increased skull size" RELATED []
is_a: MP:0010031 ! abnormal cranium size

[Term]
id: MP:0000440
name: domed cranium
def: "increased curvature to the hemispherical shape of the upper cranial case" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "dome-shaped skull" EXACT []
synonym: "domed skull" RELATED []
is_a: MP:0000438 ! abnormal cranium morphology

[Term]
id: MP:0000441
name: increased cranium width
def: "having an increased side-to-side, or lateral distance of the cranium" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased skull width" BROAD []
synonym: "wide skull" BROAD []
is_a: MP:0010031 ! abnormal cranium size

[Term]
id: MP:0000443
name: abnormal snout morphology
alt_id: MP:0000444
def: "any structural anomaly of the anterior facial part of the face or muzzle containing the oral and nasal regions" [https://orcid.org/0000-0003-3691-0324]
comment: The term muzzle has multiple meanings and can be ambiguous. It has been added as a broad synonym, and in this case, refers both to the protruding part of the face seen in many animal species.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal muzzle morphology" BROAD []
synonym: "abnormal nose shape" NARROW []
synonym: "abnormal snout" BROAD []
synonym: "abnormal snout shape" NARROW []
synonym: "snout abnormalities" BROAD []
synonym: "snout dysplasia" BROAD []
synonym: "snout shape abnormalities" NARROW []
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0000445
name: short snout
def: "reduced length of the anterior facial part of the muzzle" [PMID:9949198]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased snout length" EXACT []
synonym: "short nasal dorsum" NARROW []
synonym: "short nasal ridge" NARROW []
synonym: "short nose" NARROW []
synonym: "short nose ridge" NARROW []
is_a: MP:0030190 ! small snout

[Term]
id: MP:0000446
name: long snout
def: "the anterior facial part of the muzzle having a length greater than seen in controls" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased snout length" EXACT []
synonym: "long nose" NARROW []
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0000447
name: flattened snout
def: "a snout flattened laterally along the whole length without the appearance of distinctive curvature" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0000448
name: pointed snout
def: "muzzle tapers to a small tip, sharper angle than wild type" [PMID:7958926]
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0000449
name: broad nasal bridge
def: "wider than normal upper part of the ridge of the nose" [PMID:9949198]
synonym: "broadened nasal bridge" EXACT []
synonym: "wide nasal bridge" EXACT []
synonym: "widened nasal bridge" EXACT []
is_a: MP:0030033 ! abnormal nasal bridge morphology

[Term]
id: MP:0000450
name: absent snout
def: "absence of the anterior facial part of the face or muzzle containing the oral and nasal regions" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of snout" EXACT []
synonym: "absent nose" NARROW []
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0000451
name: scaly muzzle
def: "loss of the outer layer of the epidermis of the muzzle in thick, dry scale-like patches" [PMID:10419685]
synonym: "scaly snout" EXACT []
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0000452
name: abnormal mouth morphology
def: "any structural anomaly of the proximal portion of the digestive tract containing the oral cavity and bounded by the oral opening" [UBERON:0000165]
comment: In vertebrates, the mouth extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these protrude from the mouth (tusks). {xref="UBERON:0000165"}
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "mouth abnormalities" BROAD []
synonym: "mouth dysplasia" NARROW []
synonym: "mouth malformation" EXACT []
xref: Fyler:4874
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0000453
name: absent mouth
def: "congenital absence of the mouth" [PMID:8837770]
synonym: "absence of mouth" EXACT []
synonym: "astomia" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology

[Term]
id: MP:0000454
name: abnormal jaw morphology
def: "any structural anomaly of the bony framework of the mouth where the teeth are held" [ISBN:0-683-40008-8]
synonym: "jaw abnormalities" BROAD []
synonym: "jaw dysplasia" NARROW []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0000455
name: abnormal maxilla morphology
alt_id: MP:0000089
def: "any structural anomaly of the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal upper jaw morphology" EXACT []
synonym: "maxilla dysplasia" NARROW []
is_a: MP:0000454 ! abnormal jaw morphology

[Term]
id: MP:0000457
name: maxilla hypoplasia
alt_id: MP:0000092
def: "decrease in the number of normal cells in normal arrangement in the maxilla, typically resulting in decreased size" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "hypoplasia of maxilla" EXACT []
synonym: "hypoplasia of upper jaw" EXACT []
synonym: "hypoplastic maxilla" EXACT []
synonym: "hypoplastic upper jaw" EXACT []
is_a: MP:0004540 ! small maxilla
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0000458
name: abnormal mandible morphology
alt_id: MP:0000086
def: "any structural anomaly of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal lower jaw morphology" EXACT []
synonym: "mandible dysplasia" NARROW []
is_a: MP:0000454 ! abnormal jaw morphology

[Term]
id: MP:0000459
name: abnormal presacral vertebrae morphology
def: "any structural anomaly of the vertebrae anterior to the sacrum" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0000460
name: mandible hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mandible, typically resulting in decreased size" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "hypognathia" EXACT []
synonym: "hypoplasia of lower jaw" EXACT []
synonym: "hypoplasia of mandible" EXACT []
synonym: "hypoplastic lower jaw" EXACT []
synonym: "hypoplastic mandible" EXACT []
synonym: "mandibular hypoplasia" EXACT []
is_a: MP:0004592 ! small mandible
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0000461
name: decreased presacral vertebrae number
def: "reduced number of the vertebrae anterior to the sacrum" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased number of presacral vertebrae" EXACT []
synonym: "reduced number of presacral vertebrae" EXACT []
synonym: "reduced presacral vertebrae number" EXACT []
is_a: MP:0000459 ! abnormal presacral vertebrae morphology
is_a: MP:0004645 ! decreased vertebrae number

[Term]
id: MP:0000462
name: abnormal digestive system morphology
alt_id: MP:0000463
alt_id: MP:0002141
def: "any structural anomaly of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [ISBN:0-683-40008-8, MGI:cwg]
subset: IMPC_Prenatal
synonym: "digestive system abnormalities" BROAD []
synonym: "digestive system defects" BROAD []
synonym: "digestive system dysplasia" NARROW []
synonym: "digestive system: dysmorphology" EXACT []
xref: MGI:2173601
is_a: MP:0005381 ! digestive/alimentary phenotype

[Term]
id: MP:0000464
name: increased presacral vertebrae number
def: "greater number of the vertebrae anterior to the sacrum" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased number of presacral vertebrae" EXACT []
is_a: MP:0000459 ! abnormal presacral vertebrae morphology
is_a: MP:0004644 ! increased vertebrae number

[Term]
id: MP:0000465
name: gastrointestinal hemorrhage
def: "bleeding in the stomach and/or the intestines" [ISBN:0-683-40008-8, MGI:tc, PMID:10716451]
synonym: "gastroenteric bleeding" EXACT []
synonym: "gastroenteric haemorrhage" EXACT []
synonym: "gastroenteric hemorrhage" EXACT []
synonym: "gastrointestinal bleeding" EXACT []
synonym: "gastrointestinal haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0001663 ! abnormal digestive system physiology

[Term]
id: MP:0000466
name: esophageal epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the esophageal epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplasia of the esophageal epithelium" EXACT []
synonym: "hyperplasia of the oesophageal epithelium" EXACT []
synonym: "hyperplastic esophageal epithelium" EXACT []
synonym: "oesophageal epithelium hyperplasia" EXACT []
is_a: MP:0000468 ! abnormal esophageal epithelium morphology

[Term]
id: MP:0000467
name: abnormal esophagus morphology
def: "any structural anomaly of the part of the digestive canal through which food passes from the pharynx to the stomach" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal oesophagus morphology" EXACT []
synonym: "esophageal dysplasia" NARROW []
synonym: "esophagus abnormalities" BROAD []
synonym: "esophagus dysplasia" NARROW []
synonym: "oesophageal dysplasia" NARROW []
synonym: "oesophagus abnormalities" BROAD []
synonym: "oesophagus dysplasia" NARROW []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0000468
name: abnormal esophageal epithelium morphology
def: "any structural anomaly of the epithelial layer that lines the luminal space of the esophagus" [ISBN:0-683-40008-8]
synonym: "abnormal esophageal epithelium dysplasia" NARROW []
synonym: "abnormal oesophageal epithelium dysplasia" NARROW []
synonym: "abnormal oesophageal epithelium morphology" EXACT []
synonym: "esophageal epithelium abnormalities" BROAD []
synonym: "oesophageal epithelium abnormalities" BROAD []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0000469
name: abnormal esophageal squamous epithelium morphology
def: "any structural anomaly of the scaly epithelial layer of the esophagus" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "abnormal oesophageal squamous epithelium morphology" EXACT []
synonym: "esophageal squamous epithelium dysplasia" NARROW []
synonym: "oesophageal squamous epithelium dysplasia" NARROW []
is_a: MP:0000468 ! abnormal esophageal epithelium morphology

[Term]
id: MP:0000470
name: abnormal stomach morphology
def: "any structural anomaly of the hollow, sac-like structure of the digestive canal between the esophagus and the small intestine that functions to emulsify food" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal gastric morphology" EXACT []
synonym: "gastric abnormalities" BROAD []
synonym: "gastric dysplasia" NARROW []
synonym: "stomach abnormalities" BROAD []
synonym: "stomach dysplasia" NARROW []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0000471
name: abnormal stomach epithelium morphology
def: "any structural anomaly of the epithelial layer of the stomach" [MGI:tc]
synonym: "stomach epithelium abnormalities" BROAD []
synonym: "stomach epithelium dysplasia" NARROW []
is_a: MP:0010792 ! abnormal stomach mucosa morphology

[Term]
id: MP:0000472
name: abnormal stomach non-glandular epithelium morphology
def: "any structural anomaly of the squamous epithelium that lines the distinct rodent non-glandular region of the stomach, i.e. the forestomach (aka anterior or proximal stomach); in neonatal and adult mice, this epithelium is stratified, fully keratinized, and devoid of gastric glands" [ISBN:0-683-40008-8, PMID:22750256]
synonym: "abnormal stomach squamous epithelium morphology" EXACT []
synonym: "stomach squamous epithelium dysplasia" NARROW []
is_a: MP:0000471 ! abnormal stomach epithelium morphology

[Term]
id: MP:0000473
name: abnormal stomach glandular epithelium morphology
def: "any structural anomaly of the gland-containing epithelial layer of the stomach" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "stomach glandular epithelium dysplasia" NARROW []
is_a: MP:0000471 ! abnormal stomach epithelium morphology

[Term]
id: MP:0000474
name: abnormal foregut morphology
def: "any structural anomaly of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "foregut abnormalities" BROAD []
synonym: "foregut dysplasia" NARROW []
is_a: MP:0003119 ! abnormal digestive system development

[Term]
id: MP:0000476
name: obsolete thickening of bowel wall
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000477
name: abnormal intestine morphology
alt_id: MP:0000475
def: "any structural anomaly of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions" [ISBN:0-683-40008-8]
synonym: "abnormal bowel morphology" EXACT []
synonym: "abnormal bowel wall morphology" NARROW []
synonym: "bowel wall abnormalities" NARROW []
synonym: "intestinal abnormalities" BROAD []
synonym: "intestinal dysplasia" NARROW []
synonym: "intestine dysplasia" NARROW []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0000478
name: delayed intestine development
def: "slowed progression to a structurally mature intestine" [MGI:cwg]
synonym: "developmental retardation of the intestine" EXACT []
is_a: MP:0010158 ! abnormal intestine development

[Term]
id: MP:0000479
name: abnormal enterocyte morphology
def: "any structural anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584]
synonym: "abnormal enterocytes" BROAD []
synonym: "abnormal intestinal cell morphology" BROAD []
synonym: "abnormal intestinal epithelial cell" EXACT []
synonym: "intestinal cell abnormalities" BROAD []
is_a: MP:0000488 ! abnormal intestinal epithelium morphology

[Term]
id: MP:0000480
name: increased rib number
def: "greater than normal numbers of the pairs of bony structures that are elements of the body wall" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased number of ribs" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0000481
name: abnormal enterocyte cell number
def: "deviation from the normal numbers of enterocytes" [CL:0000584]
synonym: "abnormal enterocyte number" EXACT []
synonym: "abnormal intestinal cell number" RELATED []
is_a: MP:0000479 ! abnormal enterocyte morphology

[Term]
id: MP:0000482
name: long fibula
def: "increased length of the lateral and smaller of bone of the lower leg" [https://orcid.org/0000-0002-0371-1954]
synonym: "increased fibula length" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology
is_a: MP:0004695 ! increased length of long bones

[Term]
id: MP:0000483
name: obsolete Increased intestinal cell number
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "increased enterocyte number" EXACT []
is_obsolete: true

[Term]
id: MP:0000484
name: abnormal pulmonary artery morphology
def: "any structural anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs" [MESH:A07.231.114.715, MGI:hdene]
subset: CvDC_Terms
synonym: "abnormal PA" BROAD []
synonym: "pulmonary arterial abnormality" BROAD []
synonym: "pulmonary artery dysplasia" NARROW []
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0000485
name: obsolete Decreased intestinal cell number
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased enterocyte number" EXACT []
is_obsolete: true

[Term]
id: MP:0000486
name: abnormal pulmonary trunk morphology
def: "any structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [ISBN:0-683-40008-8, MGI:hdene]
subset: CvDC_Terms
synonym: "pulmonary trunk (MPA) abnormality" BROAD []
synonym: "pulmonary trunk dysplasia" NARROW []
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0000487
name: absent enterocytes
alt_id: MP:0000347
def: "absence of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584]
synonym: "absence of enterocytes" EXACT []
synonym: "absence of intestinal cell" BROAD []
synonym: "absent intestinal cell" BROAD []
synonym: "loss of enterocyte" EXACT []
synonym: "loss of intestinal cell" BROAD []
is_a: MP:0000339 ! decreased enterocyte cell number

[Term]
id: MP:0000488
name: abnormal intestinal epithelium morphology
def: "any structural anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "intestinal epithelium abnormalities" BROAD []
synonym: "intestinal epithelium dysplasia" NARROW []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0000489
name: abnormal large intestine morphology
def: "any structural anomaly of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal" [ISBN:0-683-40008-8]
synonym: "abnormal intestinum crassum" EXACT []
synonym: "large intestine abnormalities" BROAD []
synonym: "large intestine dysplasia" NARROW []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0000490
name: abnormal crypts of Lieberkuhn morphology
def: "any structural anomaly of the tubular intestinal glands found in the mucosal membranes" [ISBN:0-683-40008-8]
synonym: "abnormal intestinal gland morphology" EXACT []
synonym: "abnormal intestinal glands" BROAD []
synonym: "crypts of Lieberkuhn dysplasia" NARROW []
synonym: "intestinal gland dysplasia" NARROW []
is_a: MP:0000511 ! abnormal intestinal mucosa morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0000491
name: crypts of Lieberkuhn abscesses
def: "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "crypt abscesses" EXACT []
is_a: MP:0000490 ! abnormal crypts of Lieberkuhn morphology

[Term]
id: MP:0000492
name: abnormal rectum morphology
def: "any structural anomaly of the terminal portion of the intestinal tube adjacent to the anus" [ISBN:0-683-40008-8]
synonym: "rectum abnormalities" BROAD []
synonym: "rectum dysplasia" NARROW []
is_a: MP:0000489 ! abnormal large intestine morphology

[Term]
id: MP:0000493
name: rectal prolapse
def: "downward movement and external appearance of the rectum through the anus" [ISBN:0-683-40008-8, MGI:tc]
is_a: MP:0000492 ! abnormal rectum morphology

[Term]
id: MP:0000494
name: abnormal cecum morphology
def: "any structural anomaly of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal caecum morphology" EXACT []
synonym: "cecum abnormalities" BROAD []
synonym: "cecum dysplasia" NARROW []
is_a: MP:0000489 ! abnormal large intestine morphology

[Term]
id: MP:0000495
name: abnormal colon morphology
def: "any structural anomaly of the portion of the large intestine between the cecum and the rectum" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "colon abnormalities" BROAD []
synonym: "colon dysplasia" NARROW []
is_a: MP:0000489 ! abnormal large intestine morphology

[Term]
id: MP:0000496
name: abnormal small intestine morphology
def: "any structural anomaly of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0-683-40008-8]
synonym: "abnormal intestinum tenue morphology" EXACT []
synonym: "small intestine abnormalities" BROAD []
synonym: "small intestine dysplasia" NARROW []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0000497
name: abnormal small intestine placement
def: "different location or arrangement of the small intestinal tract" [PMID:9144284]
is_a: MP:0000496 ! abnormal small intestine morphology
is_a: MP:0014023 ! abnormal intestine placement

[Term]
id: MP:0000498
name: absent jejunum
def: "missing portion of the small intestine that extends from the duodenum to the ileum" [ISBN:0-683-40008-8]
synonym: "absence of jejunum" EXACT []
is_a: MP:0004002 ! abnormal jejunum morphology

[Term]
id: MP:0000499
name: absent ileum
def: "missing portion of the small intestine that extends from the jejunum to the colon" [ISBN:0-683-40008-8]
synonym: "absence of ileum" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology

[Term]
id: MP:0000500
name: small intestinal prolapse
def: "the descent of the small intestine through a weakness in the supporting tissues at the apex of the vagina gives rise to an enterocele, frequently caused by a weakness or separation of the cardinal and sacro-uterine ligaments" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "enterocele" EXACT []
synonym: "small intestine hernia" EXACT []
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0000501
name: abnormal digestive secretion
def: "anomaly in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal secretion" BROAD []
is_a: MP:0001664 ! abnormal digestion

[Term]
id: MP:0000502
name: obsolete abnormal digestive mucosecretion
def: "OBSOLETE. malfunctioning of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal mucosecretion" BROAD []
is_obsolete: true

[Term]
id: MP:0000503
name: excessive digestive secretion
def: "increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "excessive secretion" BROAD []
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0000504
name: obsolete excessive digestive mucosecretion
alt_id: MP:0000514
def: "increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system" [ISBN:0-683-40008-8, MGI:tc, PMID:10716451]
synonym: "excessive mucosecretion" BROAD []
is_obsolete: true
replaced_by: MP:0000503

[Term]
id: MP:0000505
name: decreased digestive secretion
def: "reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "reduced digestive secretion" EXACT []
synonym: "reduced secretion" BROAD []
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0000506
name: obsolete decreased digestive mucosecretion
alt_id: MP:0000515
def: "reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "reduced digestive mucosecretion" EXACT []
synonym: "reduced mucosecretion" BROAD []
is_obsolete: true
replaced_by: MP:0000505

[Term]
id: MP:0000507
name: absent digestive secretion
def: "failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "absence of digestive secretion" EXACT []
synonym: "absence of secretion" BROAD []
synonym: "loss of secretion" BROAD []
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0000508
name: right-sided isomerism
def: "anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the right side of the body; this may also be associated with absence of the spleen" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004133 ! heterotaxia

[Term]
id: MP:0000509
name: obsolete absent digestive mucosecretion
def: "failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system" [ISBN:0-683-40008-8, MGI:tc]
synonym: "absence of digestive mucosecretion" EXACT []
synonym: "absence of mucosecretion" BROAD []
synonym: "loss of mucosecretion" BROAD []
is_obsolete: true
replaced_by: MP:0000507

[Term]
id: MP:0000510
name: remittent intestinal hemorrhage
def: "loss of blood from the intestines that is characterized by temporary periods of abatement" [ISBN:0-683-40008-8]
synonym: "remittent intestinal bleeding" EXACT []
synonym: "remittent intestinal haemorrhage" EXACT []
is_a: MP:0031154 ! intestinal hemorrhage

[Term]
id: MP:0000511
name: abnormal intestinal mucosa morphology
def: "any structural anomaly of the mucous lining of the intestine; this consists of epithelium, lamina propria, and a layer of smooth muscle cells" [ISBN:0-683-40008-8]
synonym: "abnormal mucosa of the intestine" BROAD []
synonym: "intestinal mucosa abnormalities" BROAD []
synonym: "intestinal mucosa dysplasia" NARROW []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0000512
name: intestinal ulcer
def: "lesions in the mucous lining of the intestine" [MGI:cwg]
synonym: "intestinal ulcers" EXACT []
synonym: "mucosal ulceration of the intestine" EXACT []
is_a: MP:0000511 ! abnormal intestinal mucosa morphology
is_a: MP:0003300 ! gastrointestinal ulcer

[Term]
id: MP:0000513
name: obsolete infiltration of lymphocytes/plasma cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "lymphocyte/plasma cell infiltration" EXACT []
is_obsolete: true

[Term]
id: MP:0000516
name: abnormal renal/urinary system morphology
alt_id: MP:0000517
def: "any structural anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal urinary organs" BROAD []
synonym: "excretory system defects" BROAD []
synonym: "urinary organ abnormalities" BROAD []
synonym: "urinary system dysplasia" NARROW []
is_a: MP:0005367 ! renal/urinary system phenotype

[Term]
id: MP:0000519
name: hydronephrosis
def: "dilation of the pelvis and calices of one or both kidneys" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "hydropic kidney" EXACT []
synonym: "renal pelvic dilation" EXACT []
xref: Fyler:4502
is_a: MP:0004194 ! abnormal kidney pelvis morphology

[Term]
id: MP:0000520
name: absent kidney
def: "absence of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "absence of kidney" BROAD []
synonym: "Agenesis of kidneys" EXACT []
synonym: "bilateral kidney agenesis" EXACT []
synonym: "bilateral renal agenesis" EXACT []
synonym: "kidney agenesis" BROAD []
synonym: "renal agenesis" BROAD []
xref: Fyler:4503
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0000521
name: abnormal kidney cortex morphology
def: "any structural anomaly of the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration; it contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal renal cortex morphology" EXACT []
synonym: "kidney cortex dysplasia" NARROW []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0000522
name: kidney cortex cyst
def: "presence of one or more abnormal membranous sacs in the kidney cortex" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "cystic kidney cortex" EXACT []
synonym: "cystic renal cortex" EXACT []
synonym: "cysts in kidney cortex" EXACT []
synonym: "kidney cortex cysts" EXACT []
synonym: "renal cortex cyst" EXACT []
synonym: "renal cortex cysts" EXACT []
synonym: "renal cortical cyst" EXACT []
synonym: "renal cortical cysts" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
is_a: MP:0003675 ! kidney cyst

[Term]
id: MP:0000523
name: cortical renal glomerulopathies
def: "any disease of the capillary plexus in the kidney cortex" [ISBN:0-683-40008-8]
is_a: MP:0005325 ! abnormal renal glomerulus morphology

[Term]
id: MP:0000524
name: decreased renal tubule number
def: "fewer of the loops of Henle, the proximal convoluted tubules or the distal convoluted tubules" [PMID:9144284]
synonym: "reduced number of renal tubules" EXACT []
synonym: "reduced renal tubule number" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0000525
name: renal tubular acidosis
def: "a clinical syndrome characterized by the inability to acidify urine" [ISBN:0-683-40008-8]
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0003031 ! acidosis

[Term]
id: MP:0000526
name: small inner medullary pyramid
def: "reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules" [ISBN:0-683-40008-8, PMID:9144284]
is_a: MP:0004192 ! abnormal kidney pyramid morphology
is_a: MP:0011333 ! abnormal kidney inner medulla morphology

[Term]
id: MP:0000527
name: abnormal kidney development
def: "any anomaly in the differentiation of the paired organs responsible for urine secretion" [MGI:cwg]
subset: IMPC_Prenatal
synonym: "abnormal nephrogenesis" EXACT []
synonym: "abnormal renal development" EXACT []
synonym: "kidney development abnormalities" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0003942 ! abnormal urinary system development

[Term]
id: MP:0000528
name: delayed kidney development
alt_id: MP:0000529
def: "late onset of the induction and/or differentiation of the kidney" [PMID:7926784]
synonym: "delayed renal development" EXACT []
synonym: "developmental retardation of kidney" EXACT []
is_a: MP:0000527 ! abnormal kidney development

[Term]
id: MP:0000530
name: abnormal kidney vasculature morphology
def: "any structural anomaly of the network of tubes that carries blood through the organ of excretion" [ISBN:0-683-40008-8]
synonym: "abnormal kidney blood vessel morphology" EXACT []
synonym: "abnormal renal vasculature morphology" EXACT []
synonym: "kidney vasculature abnormalities" BROAD []
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0000531
name: right pulmonary isomerism
def: "anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the right side of the body" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000508 ! right-sided isomerism
is_a: MP:0009569 ! abnormal left lung morphology
is_a: MP:0010853 ! abnormal lung position or orientation

[Term]
id: MP:0000532
name: kidney vascular congestion
alt_id: MP:0000257
def: "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [ISBN:0-683-40008-8, MGI:tc]
synonym: "congested kidney vasculature" EXACT []
is_a: MP:0000530 ! abnormal kidney vasculature morphology
is_a: MP:0010017 ! visceral vascular congestion

[Term]
id: MP:0000533
name: kidney hemorrhage
def: "bleeding in the organ of excretion" [ISBN:0-683-40008-8, MGI:tc]
synonym: "kidney bleeding" EXACT []
synonym: "kidney haemorrhage" EXACT []
synonym: "renal haemorrhage" EXACT []
synonym: "renal hemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0000534
name: abnormal ureter morphology
def: "any structural anomaly of the tube that conducts the urine from the renal pelvis to the bladder" [ISBN:0-683-40008-8]
synonym: "ureter abnormalities" BROAD []
synonym: "ureter dysplasia" NARROW []
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0000535
name: ureter urothelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the ureter urothelium, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplasia of the luminal epithelium of ureter" EXACT []
synonym: "hyperplastic ureter urothelium" EXACT []
synonym: "luminal epithelium of ureter hyperplasia" EXACT []
is_a: MP:0011484 ! abnormal ureter urothelium morphology

[Term]
id: MP:0000536
name: hydroureter
def: "distention of the ureter with urine, due to blockage from any cause" [ISBN:0-683-40008-8, MGI:cml]
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0000537
name: abnormal urethra morphology
def: "any structural anomaly of the fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urogenital canal morphology" EXACT []
synonym: "urethra abnormalities" BROAD []
synonym: "urethra dysplasia" NARROW []
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0000538
name: abnormal urinary bladder morphology
def: "any structural anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8]
synonym: "abnormal cystis urinaria morphology" EXACT []
synonym: "abnormal urocyst morphology" EXACT []
synonym: "abnormal urocystis morphology" EXACT []
synonym: "abnormal vesica morphology" EXACT []
synonym: "abnormal vesica urinaria morphology" EXACT []
synonym: "urinary bladder dysplasia" NARROW []
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0000539
name: distended urinary bladder
def: "stretched musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8]
synonym: "dilated urinary bladder" EXACT []
synonym: "megabladder" EXACT []
synonym: "megacystis" EXACT []
synonym: "megalocystis" EXACT []
synonym: "urinary bladder dilation" EXACT []
synonym: "urinary bladder distension" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0000540
name: abnormal urinary bladder urothelium morphology
def: "any structural anomaly of the epithelial lining of the luminal space of the urinary bladder" [MGI:tc]
synonym: "abnormal urinary bladder epithelium morphology" EXACT []
synonym: "abnormal urinary bladder transitional epithelium morphology" EXACT []
synonym: "urinary bladder epithelium dysplasia" NARROW []
synonym: "urinary bladder transitional epithelium dysplasia" NARROW []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0003630 ! abnormal urothelium morphology

[Term]
id: MP:0000541
name: obsolete abnormal urinary bladder transitional epithelium morphology
def: "any structural anomaly of the transitional epithelial layer of the urinary bladder" [MGI:tc]
comment: This term is identical to MP:0000540.
synonym: "urinary bladder transitional epithelium dysplasia" EXACT []
is_obsolete: true
replaced_by: MP:0000540

[Term]
id: MP:0000542
name: left-sided isomerism
def: "anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the left side of the body; this may also be associated with the presence of multiple spleens" [https://orcid.org/0000-0003-4606-0597]
synonym: "polysplenia syndrome (left isomerism)" RELATED []
xref: Fyler:0192
xref: Fyler:192
is_a: MP:0004133 ! heterotaxia

[Term]
id: MP:0000543
name: absent urinary bladder urothelium
def: "missing the transitional epithelial layer of the urinary bladder" [MGI:tc, PMID:10227294]
synonym: "absence of urinary bladder transitional epithelium" EXACT []
synonym: "absent urinary bladder transitional epithelium" EXACT []
synonym: "loss of urinary bladder transitional epithelium" BROAD []
is_a: MP:0000540 ! abnormal urinary bladder urothelium morphology

[Term]
id: MP:0000544
name: thin urinary bladder urothelium
def: "decrease in the thickness of the transitional epithelial layer of the urinary bladder" [MGI:tc, PMID:10227294]
synonym: "thin urinary bladder transitional epithelium" EXACT []
is_a: MP:0000540 ! abnormal urinary bladder urothelium morphology

[Term]
id: MP:0000545
name: obsolete abnormal limbs/digits/tail morphology
def: "OBSOLETE. morphological or developmental anomaly of the digits, autopod, limbs, or tail" [MGI:cwg]
synonym: "abnormal extremities" BROAD []
synonym: "abnormal extremity morphology" EXACT []
synonym: "extremities abnormalities" BROAD []
synonym: "extremities defects" BROAD []
synonym: "extremities dysplasia" EXACT []
synonym: "extremity dysplasia" EXACT []
synonym: "limbs/digits/tail dysplasia" EXACT []
is_obsolete: true

[Term]
id: MP:0000547
name: short limbs
alt_id: MP:0002542
def: "reduced average length of the extremities" [https://orcid.org/0000-0003-3691-0324, PMID:10742104]
subset: IMPC
subset: Sanger_Terms
synonym: "brachymelia" EXACT []
synonym: "decreased limb length" EXACT []
synonym: "reduced limb length" EXACT []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000548
name: long limbs
def: "increased average length of the extremities" [MGI:tc]
subset: IMPC
subset: Sanger_Terms
synonym: "increased limb length" EXACT []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000549
name: absent limbs
def: "absence of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of limbs" EXACT []
synonym: "ectromelic limbs" BROAD []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000550
name: abnormal forelimb morphology
def: "any structural anomaly of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal arm morphology" NARROW []
synonym: "forelimb abnormalities" BROAD []
synonym: "forelimb dysplasia" NARROW []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000551
name: absent forelimb
def: "absence of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "absence of forelimb" EXACT []
is_a: MP:0000549 ! absent limbs
is_a: MP:0000550 ! abnormal forelimb morphology

[Term]
id: MP:0000552
name: abnormal radius morphology
def: "any structural anomaly of the short bone of the lateral forearm" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "radius dysplasia" NARROW []
is_a: MP:0003855 ! abnormal forelimb zeugopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0000553
name: absent radius
def: "missing the short bone of the lateral forearm" [ISBN:0-683-40008-8, PMID:10227294]
synonym: "absence of radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology

[Term]
id: MP:0000554
name: abnormal carpal bone morphology
def: "any structural anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [ISBN:0-683-40008-8, ISBN:978-0028454405]
comment: Note that the bony structure of the human and rodent carpals are different.
synonym: "abnormal carpal bone" BROAD []
synonym: "abnormal carpus" BROAD []
synonym: "carpal bone dysplasia" NARROW []
synonym: "carpus dysplasia" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0002115 ! abnormal limb bone morphology

[Term]
id: MP:0000555
name: absent carpal bone
def: "absence of any or all of the nine nodular bones of the joint between the forelimb bones and the front paws/hands, consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [ISBN:0-683-40008-8, ISBN:978-0028454405]
comment: Note that the bony structure of the human and rodent carpals are different.
synonym: "absence of carpal bone" EXACT []
synonym: "absent carpus" EXACT []
is_a: MP:0000554 ! abnormal carpal bone morphology

[Term]
id: MP:0000556
name: abnormal hindlimb morphology
def: "any structural anomaly of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal hind limb morphology" EXACT []
synonym: "abnormal leg morphology" NARROW []
synonym: "hind limb abnormalities" BROAD []
synonym: "hind limb dysplasia" NARROW []
synonym: "hindlimb abnormalities" BROAD []
synonym: "hindlimb dysplasia" NARROW []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000557
name: absent hindlimb
def: "absence of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of hind limb" EXACT []
synonym: "absence of hind limbs" EXACT []
synonym: "absence of hindlimb" EXACT []
synonym: "absent hind limb" EXACT []
synonym: "absent hind limbs" EXACT []
is_a: MP:0000549 ! absent limbs
is_a: MP:0000556 ! abnormal hindlimb morphology

[Term]
id: MP:0000558
name: abnormal tibia morphology
def: "any structural anomaly of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "tibia dysplasia" NARROW []
is_a: MP:0003857 ! abnormal hindlimb zeugopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0000559
name: abnormal femur morphology
def: "any structural anomaly of the long bone of the thigh" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "femur dysplasia" NARROW []
is_a: MP:0003856 ! abnormal hindlimb stylopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0000561
name: adactyly
def: "missing one or more digits, or all digits" [MGI:tc, PMID:10227294]
comment: There is ambiguity in the literature regarding the meaning of the term adactyly. Some sources define this as missing all digits and other sources list the definition as missing all or one or more digits. In this ontology, we are using the latter, more inclusive definition, even though this may confound the usage of the term oligodactyly MP:0000565.
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
synonym: "absence of digits" EXACT []
synonym: "absent fingers" NARROW []
synonym: "absent toes" NARROW []
xref: Fyler:4173
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000562
name: polydactyly
def: "greater than the normal complement of digits on one or more autopods" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "extra fingers" NARROW []
synonym: "extra toes" NARROW []
synonym: "hyperdactyly" EXACT []
synonym: "polydactylia" EXACT []
synonym: "polydactylism" EXACT []
xref: Fyler:4103
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000564
name: syndactyly
def: "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "fused fingers" NARROW []
synonym: "fused toes" NARROW []
xref: Fyler:4174
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000565
name: oligodactyly
alt_id: MP:0000563
def: "congenital condition in which some digits or parts of digits are missing" [ISBN:0-683-40008-8, PMID:9949198]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypodactyly" EXACT []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000566
name: synostosis
def: "osseous union of two bones that are not normally connected" [J:13049]
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0000567
name: truncated digits
def: "absence of the most distal region of the digits" [PMID:7925010]
synonym: "truncation of digits" EXACT []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000568
name: ectopic digits
def: "positional abnormality of a digit" [PMID:9778510]
synonym: "heterotopic digits" EXACT []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000569
name: abnormal digit pigmentation
alt_id: MP:0000570
def: "anomaly in the coloration of the fingers or toes due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:cwg, MGI:llw2]
synonym: "altered digit pigmentation" EXACT []
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0000571
name: interdigital webbing
def: "fold of skin, or web, between the toes that is not normally present" [ISBN:0-683-40008-8, PMID:9753320]
is_a: MP:0000564 ! syndactyly

[Term]
id: MP:0000572
name: abnormal autopod morphology
alt_id: MP:0004271
def: "any structural anomaly of the distal elements of the limb of vertebrates including the pedal or prehensile appendages (e.g. hand, foot, paw, phalanges and/or digits)" [https://orcid.org/0000-0003-3691-0324, PMID:12560810]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal foot morphology" NARROW []
synonym: "abnormal hand morphology" NARROW []
synonym: "abnormal paw morphology" NARROW []
synonym: "abnormal paw/hand/foot morphology" EXACT []
synonym: "abnormal paws" NARROW []
synonym: "hand and/or foot anomaly" BROAD []
synonym: "paw abnormalities" NARROW []
synonym: "paw/hand/foot dysplasia" NARROW []
xref: Fyler:4170
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0000573
name: increased hindlimb autopod size
def: "larger than average size of the rear feet" [J:51296]
synonym: "enlarged hind paws" EXACT []
synonym: "increased hind paw size" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0020242 ! increased autopod size

[Term]
id: MP:0000574
name: abnormal foot pad morphology
def: "any structural anomaly of the body of fat on the foot" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal foot pads" BROAD []
synonym: "foot pad dysplasia" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology

[Term]
id: MP:0000575
name: increased foot pad pigmentation
def: "darker color of the foot pads due to excess pigment" [MGI:cml]
subset: IMPC
subset: Sanger_Terms
synonym: "dark foot pads" EXACT []
synonym: "foot pad hyperpigmentation" EXACT []
is_a: MP:0000574 ! abnormal foot pad morphology
is_a: MP:0030051 ! increased foot pigmentation

[Term]
id: MP:0000576
name: clubfoot
def: "congenital deformation of the autopods; hind or forelimb foot is plantarflexed, inverted and adducted" [ISBN:0-683-40008-8, PMID:10709991]
subset: CvDC_Terms
synonym: "club foot" EXACT []
synonym: "clubbed feet" EXACT []
synonym: "talipes equino varus" EXACT []
synonym: "talipes equinovarus" EXACT []
xref: Fyler:4171
is_a: MP:0000572 ! abnormal autopod morphology

[Term]
id: MP:0000577
name: absent eccrine glands
alt_id: MP:0000677
def: "absence of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans" [PMID:15843440]
synonym: "absence of palmar eccrine glands" NARROW []
synonym: "absent palmar eccrine glands" NARROW []
synonym: "absent palmar sweat glands" NARROW []
synonym: "loss of palmar eccrine glands" NARROW []
is_a: MP:0013458 ! decreased eccrine gland number

[Term]
id: MP:0000578
name: ulcerated autopod
def: "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
synonym: "ulcerated paws" EXACT []
is_a: MP:0000572 ! abnormal autopod morphology

[Term]
id: MP:0000579
name: abnormal nail morphology
def: "any structural anomaly of any of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal claw morphology" RELATED []
synonym: "abnormal nails" BROAD []
synonym: "nail abnormalities" BROAD []
synonym: "nail dysplasia" NARROW []
synonym: "onychodystrophy" NARROW []
is_a: MP:0010678 ! abnormal skin adnexa morphology

[Term]
id: MP:0000580
name: deformed nails
def: "atypical shape or size of the nails" [PMID:9420327]
subset: Europhenome_Terms
subset: IMPC
synonym: "deformed claw" RELATED []
is_a: MP:0000579 ! abnormal nail morphology

[Term]
id: MP:0000581
name: obsolete ventral nails/ hair
def: "OBSOLETE. appearance of nails and hair on the ventral side of the paw" [PMID:9778510]
is_obsolete: true

[Term]
id: MP:0000582
name: toenail hyperkeratosis
def: "keratin extensions from the toenails" [J:62478]
is_a: MP:0000579 ! abnormal nail morphology

[Term]
id: MP:0000583
name: long toenails
def: "increased length of the toenails" [PMID:1709129]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased toenail length" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0012401 ! long nails

[Term]
id: MP:0000585
name: kinked tail
alt_id: MP:0000586
alt_id: MP:0000591
def: "a sharp bend or zigzag in the tail" [PMID:10709991]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "crooked tail" EXACT []
synonym: "kinky tail" EXACT []
synonym: "tail kinks" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0000588
name: thick tail
def: "a tail with a greater diameter than normal" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0000589
name: thin tail
def: "a tail with a smaller diameter than normal" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0000592
name: short tail
alt_id: MP:0000587
def: "reduced length of tail compared to control" [PMID:10572046]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased tail length" EXACT []
synonym: "reduced tail length" EXACT []
synonym: "stubbed tail" EXACT []
is_a: MP:0011999 ! abnormal tail length

[Term]
id: MP:0000593
name: obsolete tail band
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000596
name: abnormal liver development
def: "any anomaly in the differentiation of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal hepatic development" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0003943 ! abnormal hepatobiliary system development

[Term]
id: MP:0000597
name: delayed hepatic development
def: "late onset of the induction and/or differentiation of the liver" [PMID:7926784]
is_a: MP:0000596 ! abnormal liver development

[Term]
id: MP:0000598
name: abnormal liver morphology
alt_id: MP:0000595
def: "any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: IMPC_Prenatal
synonym: "abnormal hepatic morphology" EXACT []
synonym: "abnormal liver" BROAD []
synonym: "liver dysplasia" NARROW []
xref: Fyler:4447
is_a: MP:0002138 ! abnormal hepatobiliary system morphology

[Term]
id: MP:0000599
name: enlarged liver
def: "larger than average size of the liver" [PMID:8941642]
synonym: "hepatomegaly" EXACT []
synonym: "increased liver size" EXACT []
is_a: MP:0004848 ! abnormal liver size
is_a: MP:0013328 ! visceromegaly

[Term]
id: MP:0000600
name: liver hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the liver, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hepatic hypoplasia" RELATED []
synonym: "hypoplastic liver" EXACT []
is_a: MP:0000601 ! small liver

[Term]
id: MP:0000601
name: small liver
def: "reduced size of the liver" [PMID:7854452]
synonym: "decreased liver size" EXACT []
synonym: "reduced liver size" EXACT []
is_a: MP:0004848 ! abnormal liver size

[Term]
id: MP:0000602
name: dilated liver sinusoidal space
def: "the luminal space of one or more liver sinusoids is increased in volume or area" [PMID:15361506, PMID:29844855, PMID:7854452]
comment: Hepatic sinusoidal dilatation can be caused by hepatic venous outflow obstruction or extrahepatic inflammatory conditions; the dilated lumens can appear congested and packed with erythrocytes. Per PMID:15361506 and PMID:29844855, hepatic sinusoidal dilatation is defined as sinusoidal space (lumen) more than one hepatocyte plate in width {xref="https://radiopaedia.org/articles/hepatic-sinusoidal-dilatation", xref="https://tpis.upmc.com/tpislibrary/dlp/Chap11frame.html"}
synonym: "dilated liver sinusoidal spaces" EXACT []
synonym: "enlarged hepatic sinusoidal space" EXACT []
synonym: "enlarged hepatic sinusoidal spaces" EXACT []
synonym: "hepatic sinusoidal dilation" EXACT []
synonym: "increased liver sinusoidal space size" EXACT []
synonym: "liver sinusoidal space dilation" EXACT []
is_a: MP:0008989 ! abnormal liver sinusoid morphology

[Term]
id: MP:0000603
name: pale liver
def: "liver lacking normal coloration, often refers to bloodless condition" [PMID:7926784]
subset: IMPC_Prenatal
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0000604
name: amyloidosis
alt_id: MP:0000695
def: "an accumulation of extracellular amyloid deposits in tissues of the body" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased amyloid deposition" EXACT []
is_a: MP:0021152 ! abnormal amyloid deposition

[Term]
id: MP:0000606
name: decreased hepatocyte number
def: "fewer than normal number of parenchymal liver cells" [PMID:7854452]
synonym: "reduced hepatocyte cell number" EXACT []
is_a: MP:0000607 ! abnormal hepatocyte morphology

[Term]
id: MP:0000607
name: abnormal hepatocyte morphology
alt_id: MP:0000605
alt_id: MP:0002821
def: "any structural anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MESH:A11.436.348, PMID:7854452]
synonym: "abnormal hepatocytes" BROAD []
synonym: "abnormal liver cells" BROAD []
is_a: MP:0008987 ! abnormal liver lobule morphology

[Term]
id: MP:0000608
name: dissociated hepatocytes
def: "disorganization of cohesive hepatocyte structure" [PMID:7854452]
synonym: "dissociation of liver parenchymal cells" EXACT []
is_a: MP:0000607 ! abnormal hepatocyte morphology

[Term]
id: MP:0000609
name: abnormal liver physiology
def: "any functional anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage" [ISBN:0-683-40008-8]
synonym: "abnormal hepatic function" EXACT []
synonym: "abnormal hepatic physiology" EXACT []
synonym: "abnormal liver function" EXACT []
is_a: MP:0002139 ! abnormal hepatobiliary system physiology

[Term]
id: MP:0000610
name: cholestasis
def: "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MESH:C06.130.120.135]
synonym: "bile duct obstruction" EXACT []
synonym: "bile stasis" EXACT []
synonym: "biliary stasis" EXACT []
is_a: MP:0003252 ! abnormal bile duct physiology

[Term]
id: MP:0000611
name: jaundice
def: "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MESH:C23.550.429.500]
synonym: "icterus" EXACT []
is_a: MP:0000609 ! abnormal liver physiology

[Term]
id: MP:0000612
name: obsolete sclerosis
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000613
name: abnormal salivary gland morphology
def: "any structural anomaly of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "abnormal salivary glands" BROAD []
synonym: "salivary gland dysplasia" NARROW []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0013544 ! abnormal merocrine gland morphology

[Term]
id: MP:0000614
name: absent salivary gland
def: "missing any of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "absence of salivary glands" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0000615
name: abnormal palatine gland morphology
def: "any structural anomaly of the salivary gland of the hard palate" [ISBN:0-683-40008-8, PMID:11002344]
synonym: "abnormal glandulae palatinae morphology" EXACT []
synonym: "palatine gland dysplasia" NARROW []
is_a: MP:0003791 ! abnormal minor salivary gland morphology
is_a: MP:0014032 ! abnormal mucous gland morphology

[Term]
id: MP:0000616
name: decreased ductal branching in the palatine gland
def: "fewer branches and distal tips of the vesicles of the palatine gland" [PMID:11002344]
synonym: "reduced ductal branching in the palatine gland" EXACT []
is_a: MP:0000615 ! abnormal palatine gland morphology
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0000617
name: increased salivary gland mucosal cell number
def: "greater than normal number of cells that form mucus in the salivary glands" [PMID:11002344]
synonym: "increased number of salivary gland mucosal cells" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0000618
name: small salivary gland
def: "reduced size of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "decreased salivary gland size" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0000619
name: salivary gland epithelial hyperplasia
def: "increase in the number of normal cells in normal arrangement in the salivary gland epithelium, typically resulting in increased size" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "hyperplastic salivary gland epithelium" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0000620
name: narrow salivary ducts
def: "reduced diameter of the tubular canals that carry saliva" [ISBN:0-683-40008-8, PMID:10906459]
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0000621
name: increased salivary adenocarcinoma incidence
alt_id: MP:0002040
def: "greater than the expected number of a malignant neoplasm of the secreting cells of the salivary gland, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "acinar carcinoma" RELATED []
synonym: "acinic cell adenocarcinoma" RELATED []
synonym: "acinic cell carcinoma" RELATED []
synonym: "salivary adenocarcinoma" RELATED []
synonym: "Salivary Adenocarcinomas" RELATED []
is_a: MP:0009308 ! increased adenocarcinoma incidence
is_a: MP:0010318 ! increased salivary gland tumor incidence

[Term]
id: MP:0000622
name: increased salivation
def: "greater than normal amounts of flowing saliva" [ISBN:0-683-40008-8]
synonym: "excess salivation" EXACT []
synonym: "hygrostomia" EXACT []
synonym: "hypersalivation" EXACT []
synonym: "ptyalism" EXACT []
synonym: "sialism" EXACT []
synonym: "sialismus" EXACT []
synonym: "sialorrhea" NARROW []
synonym: "sialosis" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation
is_a: MP:0005310 ! abnormal salivary gland physiology

[Term]
id: MP:0000623
name: decreased salivation
def: "reduction in the flow, secretion, or amount of saliva" [MGI:cwg]
synonym: "hyposalivation" EXACT []
synonym: "reduced salivation" EXACT []
synonym: "sialoschesis" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation
is_a: MP:0005310 ! abnormal salivary gland physiology

[Term]
id: MP:0000624
name: xerostomia
def: "dryness of the mouth resulting from reduced salivary secretion" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "dry mouth" EXACT []
is_a: MP:0000623 ! decreased salivation
is_a: MP:0003745 ! abnormal oral mucosa morphology

[Term]
id: MP:0000627
name: abnormal mammary gland morphology
def: "any structural anomaly of the compound, alveolar and apocrine accessory gland of the skin of mammals that secretes milk" [ISBN:0-683-40008-8]
comment: The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
synonym: "abnormal Brustdruese morphology" RELATED []
synonym: "abnormal dug morphology" RELATED []
synonym: "abnormal glandula mammaria morphology" EXACT []
synonym: "abnormal lactiferous gland morphology" EXACT []
synonym: "abnormal lobe of mammary gland morphology" RELATED []
synonym: "abnormal mamma morphology" RELATED []
synonym: "abnormal mammae morphology" RELATED []
synonym: "abnormal mammary glands" EXACT []
synonym: "mammary gland dysplasia" NARROW []
is_a: MP:0010678 ! abnormal skin adnexa morphology
is_a: MP:0013554 ! abnormal apocrine gland morphology

[Term]
id: MP:0000628
name: abnormal mammary gland development
alt_id: MP:0003428
def: "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [ISBN:0-683-40008-8]
synonym: "abnormal breast development" EXACT []
synonym: "abnormal Brustdruese development" EXACT []
synonym: "abnormal glandula mammaria development" EXACT []
synonym: "abnormal Lactiferous gland development" EXACT []
synonym: "abnormal lactiferous gland development" EXACT []
synonym: "abnormal Lobe of breast development" EXACT []
synonym: "abnormal lobe of breast development" EXACT []
synonym: "abnormal Lobe of mammary gland development" EXACT []
synonym: "abnormal lobe of mammary gland development" EXACT []
synonym: "abnormal mamma development" EXACT []
synonym: "abnormal mammae development" EXACT []
synonym: "abnormal mammary development" EXACT []
synonym: "abnormal mammogenesis" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology
is_a: MP:0020973 ! abnormal gland development
is_a: MP:0020982 ! abnormal skin adnexa development

[Term]
id: MP:0000629
name: absent mammary gland
def: "absence of the specialized accessory gland of the skin of mammals that secretes milk" [PMID:7958926]
synonym: "absence of mammary glands" EXACT []
synonym: "absent breast" EXACT []
synonym: "absent Brustdruese" EXACT []
synonym: "absent glandula mammaria" EXACT []
synonym: "absent Lactiferous gland" EXACT []
synonym: "absent lactiferous gland" EXACT []
synonym: "absent Lobe of breast" EXACT []
synonym: "absent lobe of breast" EXACT []
synonym: "absent Lobe of mammary gland" EXACT []
synonym: "absent lobe of mammary gland" EXACT []
synonym: "absent mamma" EXACT []
synonym: "absent mammae" EXACT []
synonym: "amastia" EXACT []
is_a: MP:0013715 ! decreased mammary gland number

[Term]
id: MP:0000630
name: mammary gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the mammary gland, typically resulting in increased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "breast hyperplasia" EXACT []
synonym: "Brustdruese hyperplasia" EXACT []
synonym: "glandula mammaria hyperplasia" EXACT []
synonym: "Lactiferous gland hyperplasia" EXACT []
synonym: "lactiferous gland hyperplasia" EXACT []
synonym: "Lobe of breast hyperplasia" EXACT []
synonym: "lobe of breast hyperplasia" EXACT []
synonym: "Lobe of mammary gland hyperplasia" EXACT []
synonym: "lobe of mammary gland hyperplasia" EXACT []
synonym: "mamma hyperplasia" EXACT []
synonym: "mammae hyperplasia" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0000631
name: abnormal neuroendocrine gland morphology
def: "any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli" [ISBN:0-683-40008-8]
synonym: "abnormal neuroendocrine glands" BROAD []
synonym: "neuroendocrine gland dysplasia" NARROW []
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0000632
name: abnormal pineal gland morphology
def: "any structural anomaly of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; it is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms; the pineal parenchyma, consisting of pinealocytes, interstitial (glial-like) cells, phagocytes and capillaries, is arranged into large folliculi separated by septae of connective tissue and blood vessels" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal conarium morphology" EXACT []
synonym: "abnormal corpus pineale morphology" EXACT []
synonym: "abnormal epiphysis cerebri morphology" EXACT []
synonym: "abnormal glandula pinealis morphology" EXACT []
synonym: "abnormal pineal body morphology" EXACT []
synonym: "abnormal pineal glands" BROAD []
synonym: "pineal gland dysplasia" NARROW []
is_a: MP:0000840 ! abnormal epithalamus morphology
is_a: MP:0013563 ! abnormal secretory circumventricular organ morphology

[Term]
id: MP:0000633
name: abnormal pituitary gland morphology
def: "any structural anomaly of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin from the anterior lobe; melanocyte stimulating hormone from the intermediate lobe and hormones involved in blood pressure regulation from the posterior lobe" [ISBN:0-683-40008-8]
synonym: "abnormal hypophysis morphology" EXACT []
synonym: "abnormal pituitary glands" BROAD []
synonym: "abnormal pituitary morphology" EXACT []
synonym: "pituitary gland dysplasia" NARROW []
is_a: MP:0000631 ! abnormal neuroendocrine gland morphology
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000635
name: pituitary gland hyperplasia
alt_id: MP:0000634
def: "increase in the number of normal cells in normal arrangement in the pituitary gland, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic pituitary gland" EXACT []
synonym: "pituitary hyperplasia" EXACT []
is_a: MP:0000636 ! enlarged pituitary gland

[Term]
id: MP:0000636
name: enlarged pituitary gland
def: "increased size of pituitary gland" [PMID:9744866]
synonym: "increased pituitary gland size" EXACT []
is_a: MP:0008936 ! abnormal pituitary gland size

[Term]
id: MP:0000637
name: obsolete abnormal merkel cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
replaced_by: MP:0000985

[Term]
id: MP:0000638
name: obsolete hyperproliferation of merkel cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0000986

[Term]
id: MP:0000639
name: abnormal adrenal gland morphology
def: "any structural anomaly of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [ISBN:0-683-40008-8]
synonym: "abnormal adrenal body morphology" EXACT []
synonym: "abnormal adrenal glands" BROAD []
synonym: "abnormal adrenal morphology" EXACT []
synonym: "abnormal suprarenal body morphology" EXACT []
synonym: "abnormal suprarenal gland morphology" EXACT []
synonym: "adrenal gland dysplasia" NARROW []
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0000640
name: adrenal gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the adrenal gland, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "adrenal hypoplasia" EXACT []
synonym: "hypoplastic adrenal gland" EXACT []
is_a: MP:0002768 ! small adrenal glands

[Term]
id: MP:0000642
name: enlarged adrenal glands
alt_id: MP:0000641
def: "increased size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [ISBN:0-683-40008-8]
synonym: "increased adrenal gland size" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0000643
name: absent adrenal medulla
def: "absence of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "absent adrenal gland medulla" EXACT []
synonym: "absent central medulla" NARROW []
synonym: "absent suprarenal gland medulla" EXACT []
is_a: MP:0008289 ! abnormal adrenal medulla morphology

[Term]
id: MP:0000644
name: dextrocardia
def: "congenital defect in which the heart is located on the right side of the thorax instead of on the left side (levocardia, the normal position)" [https://orcid.org/0000-0002-6490-7723, MESH:C14.240.400.280]
subset: CvDC_Terms
xref: Fyler:0110
xref: Fyler:110
is_a: MP:0006065 ! abnormal heart position or orientation

[Term]
id: MP:0000645
name: absent adrenergic chromaffin cells
def: "absence of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10357937]
synonym: "absence of adrenergic chromaffin cells" EXACT []
synonym: "loss of adrenergic chromaffin cells" EXACT []
is_a: MP:0003834 ! abnormal adrenergic chromaffin cell morphology

[Term]
id: MP:0000646
name: enlarged adrenocortical cells
def: "larger size of cells of the steroid hormone-producing cells of the cortex of the adrenal gland" [ISBN:0-683-40008-8, PMID:10357937]
synonym: "adrenocortical cell hypertrophy" RELATED []
synonym: "enlarged cortical cells" BROAD []
synonym: "increased adrenocortical cell size" EXACT []
is_a: MP:0008291 ! abnormal adrenocortical cell morphology

[Term]
id: MP:0000647
name: abnormal sebaceous gland morphology
alt_id: MP:0001226
def: "any structural anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts" [MGI:tc]
synonym: "sebaceous gland dysplasia" NARROW []
is_a: MP:0013543 ! abnormal holocrine gland morphology
is_a: MP:0030572 ! abnormal pilosebaceous unit morphology

[Term]
id: MP:0000648
name: absent sebaceous gland
alt_id: MP:0001227
def: "absence of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc, PMID:10227294]
synonym: "absence of sebaceous glands" EXACT []
synonym: "loss of sebaceous glands" BROAD []
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0000649
name: sebaceous gland atrophy
alt_id: MP:0001228
def: "acquired diminution of the size of the holocrine glands of the dermis that secrete sebum into the hair follicles, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, PMID:8941642]
synonym: "atrophic sebaceous gland" EXACT []
is_a: MP:0012725 ! small sebaceous gland

[Term]
id: MP:0000650
name: mesocardia
def: "congenital defect in which the heart is located in the middle of the thorax instead of on the left side (levocardia, the normal position)" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
xref: Fyler:0140
xref: Fyler:140
is_a: MP:0006065 ! abnormal heart position or orientation

[Term]
id: MP:0000652
name: enlarged sebaceous gland
alt_id: MP:0001229
def: "increased size of the sebum secreting glands of the hair shaft" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased sebaceous gland size" EXACT []
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0000653
name: abnormal sex gland morphology
def: "any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [MGI:cwg]
synonym: "abnormal genitalia gland morphology" EXACT []
synonym: "abnormal gland of genitalia" BROAD []
synonym: "abnormal gland of reproductive system" BROAD []
synonym: "abnormal reproductive gland morphology" EXACT []
synonym: "abnormal reproductive system gland morphology" EXACT []
synonym: "abnormal sex glands" BROAD []
synonym: "sex gland dysplasia" NARROW []
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0002163 ! abnormal gland morphology

[Term]
id: MP:0000654
name: absent sex gland
def: "missing any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [ISBN:0-683-40008-8]
synonym: "absence of sex glands" EXACT []
is_a: MP:0000653 ! abnormal sex gland morphology

[Term]
id: MP:0000655
name: dilated sex gland
alt_id: MP:0001118
def: "stretched appearance or excessive fluid in one or more sex glands" [J:62478]
synonym: "dilated sex glands" EXACT []
synonym: "dilation of sex glands" EXACT []
synonym: "sex gland dilation" EXACT []
is_a: MP:0000653 ! abnormal sex gland morphology

[Term]
id: MP:0000659
name: prostate gland hyperplasia
alt_id: MP:0001160
def: "increase in the number of normal cells in normal arrangement in the prostate gland, typically resulting in increased size" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "hyperplastic prostate gland" EXACT []
is_a: MP:0004958 ! enlarged prostate gland

[Term]
id: MP:0000660
name: prostate gland lateral lobe hypoplasia
alt_id: MP:0001161
def: "decrease in the number of normal cells in normal arrangement in the prostate gland lateral lobe, typically resulting in decreased size" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "hypoplastic lateral prostate" EXACT []
synonym: "hypoplastic lateral prostate lobe" EXACT []
synonym: "lateral prostate gland hypoplasia" EXACT []
synonym: "lateral prostate hypoplasia" EXACT []
synonym: "LP hypoplasia" EXACT []
is_a: MP:0009381 ! abnormal prostate gland dorsolateral lobe morphology

[Term]
id: MP:0000661
name: small prostate gland ventral lobe
alt_id: MP:0001162
def: "reduced size of the rodent prostate lobe that is located below the ventral aspect of the bladder neck" [PMID:10906459, PMID:12645922, PMID:3308446]
synonym: "decreased prostate gland ventral lobe size" EXACT []
synonym: "small ventral prostate gland" EXACT []
synonym: "small VP" EXACT []
is_a: MP:0009380 ! abnormal prostate gland ventral lobe morphology

[Term]
id: MP:0000662
name: abnormal branching of the mammary ductal tree
def: "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000628 ! abnormal mammary gland development
is_a: MP:0009503 ! abnormal mammary gland duct morphology

[Term]
id: MP:0000664
name: small prostate gland anterior lobe
alt_id: MP:0001164
def: "reduced size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [PMID:11002344, PMID:12645922, PMID:3308446]
synonym: "decreased prostate gland anterior lobe size" EXACT []
synonym: "small AP" EXACT []
synonym: "small coagulating gland" EXACT []
is_a: MP:0001163 ! abnormal prostate gland anterior lobe morphology

[Term]
id: MP:0000665
name: decreased ductal branching in the coagulating gland
alt_id: MP:0001165
def: "fewer branches and distal tips of the vesicles of the coagulating gland" [PMID:11002344]
synonym: "decreased ductal branching, coagulating gland" EXACT []
synonym: "reduced ductal branching in the coagulating gland" EXACT []
is_a: MP:0009736 ! abnormal prostate gland branching morphogenesis

[Term]
id: MP:0000666
name: decreased prostate gland duct number
alt_id: MP:0001166
def: "fewer than normal minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "decreased number of prostate ducts" EXACT []
synonym: "decreased prostate duct number" EXACT []
synonym: "reduced number of prostate ducts" EXACT []
synonym: "reduced prostate duct number" EXACT []
is_a: MP:0009734 ! abnormal prostate gland duct morphology

[Term]
id: MP:0000671
name: bulbourethral gland hypoplasia
alt_id: MP:0001171
def: "decrease in the number of normal cells in normal arrangement in the bulbourethral gland, typically resulting in decreased size" [ISBN:0-683-40008-8, PMID:10215624]
synonym: "bulbo-urethral gland hypoplasia" EXACT []
synonym: "Cowper's gland hypoplasia" EXACT []
synonym: "hypoplastic bulbourethral gland" EXACT []
synonym: "Mery gland hypoplasia" EXACT []
synonym: "reduced bulbourethral gland cellularity" EXACT []
is_a: MP:0013737 ! small bulbourethral gland

[Term]
id: MP:0000672
name: obsolete decreased mucin cell number
alt_id: MP:0001172
def: "OBSOLETE. fewer than normal number of cells that secrete fluid containing carbohydrate-rich glycoproteins" [ISBN:0-683-40008-8]
synonym: "reduced mucin cell number" EXACT []
synonym: "reduced number of mucin cells" EXACT []
is_obsolete: true

[Term]
id: MP:0000674
name: abnormal sweat gland morphology
def: "any structural anomaly of any of the coil glands of the skin that secrete sweat" [ISBN:0-683-40008-8]
synonym: "abnormal sweat glands" BROAD []
synonym: "sweat gland dysplasia" NARROW []
is_a: MP:0010678 ! abnormal skin adnexa morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0000675
name: abnormal eccrine sweat gland morphology
def: "any structural anomaly of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present" [https://orcid.org/0000-0003-3691-0324, PMID:15843440]
comment: The palmar and plantar eccrine glands of rodents are thought to provide enhanced tactile sensitivity rather than serving the thermoregulatory role ascribed to eccrine glands of the thin skin in humans.
synonym: "abnormal palmar eccrine gland morphology" NARROW []
synonym: "abnormal palmar eccrine glands" NARROW []
synonym: "abnormal palmar sweat gland morphology" NARROW []
synonym: "abnormal palmar sweat glands" NARROW []
synonym: "palmar eccrine gland dysplasia" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0000674 ! abnormal sweat gland morphology
is_a: MP:0013544 ! abnormal merocrine gland morphology

[Term]
id: MP:0000676
name: abnormal body water content
def: "more or less than the normal total amount of water retained in the body" [MGI:il]
is_a: MP:0005451 ! abnormal body composition

[Term]
id: MP:0000678
name: abnormal parathyroid gland morphology
alt_id: MP:0001735
def: "any structural anomaly of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ISBN:0-683-40008-8]
synonym: "abnormal parathyroid glands" BROAD []
synonym: "parathyroid gland dysplasia" NARROW []
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0000679
name: increased percent water in carcass
def: "more than the normal total amount of water retained in the body measured post mortem" [MGI:il]
synonym: "increased percentage water in carcass" EXACT []
is_a: MP:0000676 ! abnormal body water content

[Term]
id: MP:0000680
name: absent parathyroid glands
alt_id: MP:0001736
def: "missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH)" [ISBN:0-683-40008-8]
synonym: "absence of parathyroid glands" EXACT []
synonym: "loss of parathyroid glands" EXACT []
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0000681
name: abnormal thyroid gland morphology
alt_id: MP:0001737
alt_id: MP:0003500
def: "any structural anomaly of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [ISBN:0-683-40008-8]
synonym: "abnormal thyroid glands" BROAD []
synonym: "abnormal thyroid morphology" EXACT []
synonym: "thyroid dysplasia" NARROW []
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0000683
name: decreased percent water in carcass
def: "less than the normal total amount of water retained in the body measured post mortem" [MGI:il]
synonym: "decreased percentage water in carcass" EXACT []
synonym: "reduced percent water in carcass" EXACT []
is_a: MP:0000676 ! abnormal body water content

[Term]
id: MP:0000685
name: abnormal immune system morphology
def: "any structural anomaly in the organs or cells associated with the development and formation of lymphocytes" [MGI:cwg]
synonym: "immune system abnormalities" BROAD []
synonym: "immune system dysplasia" NARROW []
synonym: "lymphoid system abnormalities" BROAD []
synonym: "lymphopoietic system abnormalities" BROAD []
is_a: MP:0005387 ! immune system phenotype

[Term]
id: MP:0000687
name: small lymphoid organs
def: "reduced size of lymphatic tissues" [ISBN:0-683-40008-8, J:34193]
is_a: MP:0002221 ! abnormal lymph organ size

[Term]
id: MP:0000688
name: lymphoid hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lymphoid tissue, typically resulting in increased size" [MGI:cwg]
synonym: "hyperplastic lymph organ" EXACT []
synonym: "increased lymphoid tissue cellularity" EXACT []
synonym: "lymph organ hyperplasia" EXACT []
is_a: MP:0002220 ! large lymphoid organs

[Term]
id: MP:0000689
name: abnormal spleen morphology
alt_id: MP:0002226
def: "any structural anomaly of the organ that functions to filter blood and to store red corpuscles and platelets" [ISBN:0-683-40008-8]
synonym: "abnormal spleen structure" EXACT []
synonym: "abnormal splenic morphology" EXACT []
synonym: "spleen abnormalities" BROAD []
synonym: "spleen dysplasia" NARROW []
is_a: MP:0002396 ! abnormal hematopoietic system morphology/development
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0000690
name: absent spleen
def: "missing organ that functions to filter blood and to store red corpuscles and platelets" [ISBN:0-683-40008-8, PMID:10572046]
subset: CvDC_Terms
synonym: "absence of spleen" EXACT []
synonym: "asplenia" EXACT []
synonym: "splenic agenesis" EXACT []
xref: Fyler:4771
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0000691
name: enlarged spleen
def: "increased spleen size" [MGI:cwg]
synonym: "increased spleen size" EXACT []
synonym: "megosplenia" EXACT []
synonym: "splenomegalia" EXACT []
synonym: "splenomegaly" EXACT []
is_a: MP:0002224 ! abnormal spleen size
is_a: MP:0013328 ! visceromegaly

[Term]
id: MP:0000692
name: small spleen
def: "decreased spleen size" [MGI:cwg]
synonym: "decreased spleen size" EXACT []
synonym: "decreased splenic size" EXACT []
synonym: "hyposplenia" EXACT []
synonym: "reduced spleen size" EXACT []
is_a: MP:0002224 ! abnormal spleen size

[Term]
id: MP:0000693
name: spleen hyperplasia
def: "increase in the number of normal cells in normal arrangement in the spleen, typically resulting in increased size" [ISBN:0-683-40008-8, PMID:8646780]
synonym: "hyperplastic spleen" EXACT []
synonym: "increased spleen cellularity" EXACT []
synonym: "splenic hyperplasia" EXACT []
is_a: MP:0000691 ! enlarged spleen

[Term]
id: MP:0000694
name: spleen hypoplasia
alt_id: MP:0002466
def: "decrease in the number of normal cells in normal arrangement in the spleen, typically resulting in decreased size" [MGI:cwg]
synonym: "decreased spleen cellularity" EXACT []
synonym: "hypoplastic spleen" EXACT []
synonym: "splenic hypoplasia" EXACT []
is_a: MP:0000692 ! small spleen

[Term]
id: MP:0000696
name: abnormal Peyer's patch morphology
def: "any structural anomaly of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [MESH:A10.549.600, PMID:15841100]
synonym: "abnormal Peyer's patches" BROAD []
is_a: MP:0002378 ! abnormal gut-associated lymphoid tissue morphology

[Term]
id: MP:0000697
name: obsolete more prevalent Peyer's patches
def: "OBSOLETE. greater or more obvious numbers of Peyer's patches" [MGI:cwg]
is_obsolete: true
consider: MP:0008132
consider: MP:0008136

[Term]
id: MP:0000698
name: obsolete less prevalent Peyer's patches
def: "OBSOLETE. fewer or less obvious numbers of Peyer's patches" [MGI:cwg]
is_obsolete: true
consider: MP:0008133
consider: MP:0008135

[Term]
id: MP:0000700
name: abnormal lymph node number
def: "deviation from the normal number of lymph nodes" [MGI:cwg]
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0000701
name: abnormal lymph node size
def: "deviation from the normal lymph node size" [MGI:cwg]
is_a: MP:0002221 ! abnormal lymph organ size
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0000702
name: enlarged lymph nodes
def: "lymph nodes of increased size" [MGI:cwg]
synonym: "adenopathy" EXACT []
synonym: "increased lymph node size" EXACT []
synonym: "lymphadenopathy" EXACT []
is_a: MP:0000701 ! abnormal lymph node size

[Term]
id: MP:0000703
name: abnormal thymus morphology
alt_id: MP:0002366
def: "any structural anomaly of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies; the thymus also stimulates the production of certain pituitary gland hormones that promote growth and sexual maturation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal thymic morphology" EXACT []
synonym: "abnormal thymus structure" EXACT []
synonym: "thymus abnormalities" BROAD []
synonym: "thymus dysplasia" NARROW []
is_a: MP:0002396 ! abnormal hematopoietic system morphology/development
is_a: MP:0002722 ! abnormal immune system organ morphology
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0000704
name: abnormal thymus development
def: "anomaly in the formation and/or differentiation of the thymus" [MGI:cwg]
comment: in mouse, the parathyroid glands develop with the thymus from two common parathyroid/thymus primordia originating from the third pharyngeal pouch endoderm; the third pharyngeal pouches are formed at E9.5-E10 and are patterned into dorsal/anterior parathyroid and ventral/posterior thymus domains; the third pouch endoderm proliferates to form bilateral parathyroid/thymus common primordia at E11-E11.5; each primordium separates into one parathyroid gland and one thymus lobe at E12.5-E13.5, which then migrate to their eventual adult locations by about E14.5; the parathyroids locate adjacent to, or sometimes embedded within, the thyroid gland; the thymus migrates further caudally into the thorax, where the two lobes meet at the midline just above the heart; embryonic thymic remnants can give rise to ectopic thymic tissue in the neck, thyroid, and parathyroid glands; the thymus is the first of the lymphoid organs to be formed and grows considerably immediately after birth in response to postnatal antigen stimulation and the demand for large numbers of mature T cells; in rats and mice, the thymus reaches maximal size by sexual maturity and then gradually involutes {xref="PMID:17067941", xref="http://dev.biologists.org/content/138/18/3865.full.pdf", xref="PMID:21862553"}
synonym: "abnormal development of the thymus" EXACT []
synonym: "abnormal thymic development" EXACT []
synonym: "abnormal thymus organogenesis" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0020973 ! abnormal gland development
is_a: MP:0020981 ! abnormal immune system development

[Term]
id: MP:0000705
name: athymia
def: "absence of the primary lymphoid organ" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "Absence of Thymus" EXACT []
synonym: "absent thymus" EXACT []
synonym: "athymic" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0000706
name: small thymus
def: "reduced size of the thymus" [MGI:cwg]
synonym: "decreased thymus size" EXACT []
synonym: "reduced thymus size" EXACT []
is_a: MP:0002364 ! abnormal thymus size

[Term]
id: MP:0000708
name: thymus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the thymus, typically resulting in increased size" [ISBN:0-683-40008-8, PMID:8646780]
synonym: "hyperplastic thymus" EXACT []
synonym: "increased thymus cellularity" EXACT []
synonym: "thymic hyperplasia" EXACT []
is_a: MP:0000709 ! enlarged thymus

[Term]
id: MP:0000709
name: enlarged thymus
def: "increased size of thymus" [PMID:9744866]
synonym: "increased thymus size" EXACT []
is_a: MP:0002364 ! abnormal thymus size

[Term]
id: MP:0000711
name: thymus cortex hypoplasia
alt_id: MP:0005045
def: "decrease in the number of normal cells in normal arrangement in the tymus cortex, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "decreased cellularity of thymic cortex" EXACT []
synonym: "decreased thymic cortex cellularity" EXACT []
synonym: "hypoplasia of thymic cortex" EXACT []
synonym: "hypoplastic thymus cortex" EXACT []
synonym: "thymic cortex hypoplasia" EXACT []
is_a: MP:0013592 ! small thymus cortex

[Term]
id: MP:0000712
name: obsolete abnormal thymocyte
alt_id: MP:0002372
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal thymocytes" EXACT []
is_obsolete: true
consider: MP:0008037

[Term]
id: MP:0000713
name: obsolete abnormal thymocyte number
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0006387

[Term]
id: MP:0000714
name: increased thymocyte number
alt_id: MP:0000326
alt_id: MP:0000721
alt_id: MP:0001827
def: "greater than expected number of immature T cells located in the thymus" [CL:0000893]
synonym: "increased thymocyte count" EXACT []
xref: CL:0000893
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0005015 ! increased T cell number

[Term]
id: MP:0000715
name: decreased thymocyte number
alt_id: MP:0000338
alt_id: MP:0000725
alt_id: MP:0001826
def: "fewer than expected number of immature T cells located in the thymus" [CL:0000893]
synonym: "reduced thymocyte number" EXACT []
xref: CL:0000893
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0000716
name: abnormal immune system cell morphology
def: "any structural anomaly of immune cells" [MGI:cwg]
synonym: "abnormal immune cells" BROAD []
synonym: "immune system: cellular abnormalities" BROAD []
is_a: MP:0000685 ! abnormal immune system morphology

[Term]
id: MP:0000717
name: abnormal lymphocyte cell number
def: "deviation from the normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "abnormal immune cell number" BROAD []
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0002619 ! abnormal lymphocyte morphology

[Term]
id: MP:0000726
name: absent lymphocyte
def: "absence of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "absence of immune cell" BROAD []
synonym: "absence of lymphocyte" EXACT []
synonym: "loss of immune cell" BROAD []
is_a: MP:0005016 ! decreased lymphocyte cell number

[Term]
id: MP:0000727
name: absent CD8-positive, alpha-beta T cells
alt_id: MP:0000345
def: "lack of the set of single-positive T cells that express CD8 on their surface" [MGI:cwg]
synonym: "absence of CD4-8+ Cells" EXACT []
synonym: "absence of CD4-8+ cells" EXACT []
synonym: "absent CD4-8+ T cells" EXACT []
synonym: "absent CD8+ T cells" EXACT []
synonym: "absent single positive T cells" BROAD []
synonym: "Loss of CD4-8+ cells" EXACT []
is_a: MP:0008079 ! decreased CD8-positive, alpha-beta T cell number

[Term]
id: MP:0000729
name: abnormal myogenesis
def: "anomaly in embryonic formation of muscle cells or fibers" [ISBN:0-683-40008-8]
synonym: "myogenesis abnormalities" EXACT []
is_a: MP:0000733 ! abnormal muscle development

[Term]
id: MP:0000730
name: increased satellite cell number
def: "greater number of unfused cells in muscle that play a role in muscle regeneration" [PMID:9284044]
synonym: "increased number of satellite cells" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0000731
name: increased collagen deposition in the muscles
def: "accumulation of collagen within the muscles" [MGI:cwg]
is_a: MP:0000733 ! abnormal muscle development

[Term]
id: MP:0000732
name: delayed primary myocyte appearance
def: "development of initial muscle cells at a later time than is normal" [MGI:cwg]
is_a: MP:0000729 ! abnormal myogenesis

[Term]
id: MP:0000733
name: abnormal muscle development
def: "any anomaly in the differentiation of muscle tissue" [MGI:cwg]
synonym: "muscle development abnormalities" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000734
name: muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the muscle, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic muscle" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000736
name: delayed muscle development
def: "late onset of the induction and/or differentiation of skeletal muscle" [PMID:7926784]
is_a: MP:0000733 ! abnormal muscle development

[Term]
id: MP:0000737
name: abnormal myotome development
def: "malformation of or absence of the part of the somite that develops into the musculature" [ISBN:0-683-40008-8]
is_a: MP:0000729 ! abnormal myogenesis

[Term]
id: MP:0000738
name: impaired muscle contractility
def: "inability or reduced ability of a muscle to shorten or to develop increased tension" [ISBN:0-683-40008-8]
is_a: MP:0005620 ! abnormal muscle contractility

[Term]
id: MP:0000740
name: impaired smooth muscle contractility
def: "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [ISBN:0-683-40008-8]
is_a: MP:0000738 ! impaired muscle contractility

[Term]
id: MP:0000741
name: impaired contractility of urinary bladder detrusor smooth muscle
def: "inability or reduced ability of the detrusor smooth muscle of the urinary bladder to shorten or to develop increased tension voluntarily or involuntarily; stretching of the smooth muscle fibers by accumulation of urine in the bladder leads to nervous signaling giving the urge to urinate; contraction of the detrusor muscle leads to urination, via emptying of the urine contained in the bladder through the urethra and urine excretion" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "impaired contractility of detrusor muscle" EXACT []
synonym: "impaired contractility of detrusor urinae muscle" EXACT []
synonym: "impaired contractility of musculus detrusor" EXACT []
is_a: MP:0000740 ! impaired smooth muscle contractility
is_a: MP:0010386 ! abnormal urinary bladder physiology

[Term]
id: MP:0000742
name: impaired contractility of ileal smooth muscle
def: "inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension" [ISBN:0-683-40008-8]
is_a: MP:0004005 ! impaired contractility of intestinal smooth muscle

[Term]
id: MP:0000743
name: muscle spasm
alt_id: MP:0000744
def: "an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "muscle spasms" EXACT []
is_a: MP:0009046 ! muscle twitch

[Term]
id: MP:0000745
name: tremors
def: "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [ISBN:0-683-40008-8, MESH:C10.597.350.850]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "quivering" EXACT []
synonym: "shaking" EXACT []
synonym: "shivering" BROAD []
synonym: "trembling" EXACT []
synonym: "tremor" EXACT []
is_a: MP:0003492 ! abnormal involuntary movement

[Term]
id: MP:0000746
name: weakness
def: "state of being infirm or less strong than normal" [PMID:9420327]
is_a: MP:0004262 ! abnormal physical strength

[Term]
id: MP:0000747
name: muscle weakness
def: "loss of muscle strength" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0000748
name: progressive muscle weakness
def: "increasing loss of muscle strength over time" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000747 ! muscle weakness

[Term]
id: MP:0000749
name: muscle degeneration
def: "pathological deterioration of muscle tissue, often accompanied by loss of function" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000750
name: abnormal muscle regeneration
alt_id: MP:0002547
def: "anomaly in the renewal, repair, and/or regrowth of muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723, PMID:9284044]
synonym: "muscle regeneration abnormalities" EXACT []
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0000751
name: myopathy
def: "any abnormal condition or disease of the skeletal muscle" [ISBN:0-683-40008-8, PMID:9284044]
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0000752
name: dystrophic muscle
def: "progressive weakness and wasting of muscle" [ISBN:0-683-40008-8]
synonym: "muscular dystrophy" BROAD []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000753
name: paralysis
def: "severe or complete loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [ISBN:0-683-40008-8]
is_a: MP:0003491 ! abnormal voluntary movement

[Term]
id: MP:0000754
name: paresis
def: "mild or partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [ISBN:0-683-40008-8]
synonym: "partial paralysis" EXACT []
is_a: MP:0003491 ! abnormal voluntary movement

[Term]
id: MP:0000755
name: hindlimb paralysis
def: "severe or complete loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "hind limb paralysis" EXACT []
is_a: MP:0013147 ! limb paralysis

[Term]
id: MP:0000756
name: forelimb paralysis
def: "severe or complete loss of power of voluntary movement in muscles of the forelimb through injury or disease of it or its nerve supply" [ISBN:0-683-40008-8]
synonym: "fore limb paralysis" EXACT []
is_a: MP:0013147 ! limb paralysis

[Term]
id: MP:0000757
name: herniated abdominal wall
def: "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [ISBN:0-683-40008-8, PMID:9144284]
subset: CvDC_Terms
synonym: "abdominoschisis" EXACT []
synonym: "gastroschisis" NARROW []
synonym: "laparoschisis" NARROW []
synonym: "paraomphalocele" NARROW []
xref: Fyler:4414
is_a: MP:0003257 ! abnormal abdominal wall morphology

[Term]
id: MP:0000759
name: abnormal skeletal muscle morphology
def: "any structural anomaly of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8]
synonym: "abnormal skeletal muscles" BROAD []
synonym: "abnormal striated muscle morphology" RELATED []
synonym: "skeletal muscle abnormalities" BROAD []
synonym: "skeletal muscle dysplasia" NARROW []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000761
name: thin diaphragm muscle
def: "reduced thickness of the diaphragm muscle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002279 ! abnormal diaphragm morphology

[Term]
id: MP:0000762
name: abnormal tongue morphology
def: "any structural anomaly of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8]
synonym: "tongue abnormalities" BROAD []
synonym: "tongue dysplasia" NARROW []
is_a: MP:0000452 ! abnormal mouth morphology
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0000763
name: abnormal filiform papillae morphology
def: "any structural anomaly of the keratinized projections on the dorsal surface of the tongue" [PMID:9420327]
synonym: "filiform papillae dysplasia" NARROW []
is_a: MP:0000764 ! abnormal tongue epithelium morphology

[Term]
id: MP:0000764
name: abnormal tongue epithelium morphology
def: "any structural anomaly of the epithelial layer of the tongue" [ISBN:0-683-40008-8, MGI:tc]
synonym: "tongue epithelium dysplasia" NARROW []
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0000765
name: abnormal tongue squamous epithelium morphology
def: "any structural anomaly of the scaly epithelial layer of the tongue" [ISBN:0-683-40008-8, MGI:tc]
synonym: "tongue squamous epithelium dysplasia" NARROW []
is_a: MP:0000764 ! abnormal tongue epithelium morphology

[Term]
id: MP:0000766
name: absent tongue squamous epithelium
def: "missing the scaly epithelial layer of the tongue" [ISBN:0-683-40008-8, MGI:tc, PMID:10227294]
synonym: "absence of tongue squamous epithelium" EXACT []
synonym: "loss of tongue squamous epithelium" EXACT []
is_a: MP:0000765 ! abnormal tongue squamous epithelium morphology

[Term]
id: MP:0000767
name: abnormal smooth muscle morphology
def: "any structural anomaly of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc." [ISBN:0-683-40008-8]
synonym: "smooth muscle abnormalities" BROAD []
synonym: "smooth muscle dysplasia" NARROW []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0000768
name: obsolete nervous system abnormalities
def: "OBSOLETE. any malformation or anomaly in the entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses" [https://orcid.org/0000-0003-3691-0324, MESH:A08]
synonym: "nervous system defects" EXACT []
is_obsolete: true
consider: MP:0003633
consider: MP:0006387

[Term]
id: MP:0000771
name: abnormal brain size
def: "deviation from the average range of brain size for an organism" [https://orcid.org/0000-0003-3691-0324]
synonym: "brain size abnormalities" EXACT []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0000774
name: decreased brain size
alt_id: MP:0000772
def: "smaller appearance of the brain" [PMID:8837770]
subset: IMPC
subset: Sanger_Terms
synonym: "micrencephaly" EXACT []
synonym: "microencephaly" EXACT []
synonym: "reduced brain size" EXACT []
synonym: "small brain" EXACT []
synonym: "smaller brain size" EXACT []
is_a: MP:0000771 ! abnormal brain size

[Term]
id: MP:0000776
name: abnormal inferior colliculus morphology
alt_id: MP:0000902
def: "any structural anomaly of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [ISBN:0-683-40008-8]
synonym: "abnormal corpora quadrigeminum posterius morphology" EXACT []
synonym: "abnormal inferior nasal colliculus morphology" EXACT []
synonym: "abnormal posterior quadrigeminal body morphology" EXACT []
synonym: "inferior colliculus dysplasia" NARROW []
is_a: MP:0000899 ! abnormal corpora quadrigemina morphology

[Term]
id: MP:0000777
name: increased inferior colliculus size
alt_id: MP:0000903
def: "enlargement of the paired inferior eminence of the mesencephalic tectum" [ISBN:0-683-40008-8, J:57538]
synonym: "increased corpora quadrigeminum posterius size" EXACT []
synonym: "increased inferior nasal colliculus size" EXACT []
synonym: "increased posterior quadrigeminal body size" EXACT []
synonym: "increased size of inferior colliculus" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology

[Term]
id: MP:0000778
name: abnormal nervous system tract morphology
def: "any structural anomaly in the structure of any bundle of myelinated nerve fibers following a defined path through the brain and/or spinal cord" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal tract" BROAD []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0000779
name: obsolete gliosis of tract
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002183

[Term]
id: MP:0000780
name: abnormal corpus callosum morphology
def: "any structural anomaly of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "corpus callosum dysplasia" NARROW []
is_a: MP:0008219 ! abnormal dorsal telencephalic commissure morphology
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000781
name: decreased corpus callosum size
def: "smaller thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased size of corpus callosum" EXACT []
synonym: "reduced corpus callosum size" EXACT []
synonym: "reduced size of corpus callosum" EXACT []
is_a: MP:0020573 ! abnormal corpus callosum size

[Term]
id: MP:0000783
name: abnormal forebrain morphology
def: "any structural anomaly of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
synonym: "abnormal prosencephalon morphology" EXACT []
synonym: "forebrain dysplasia" NARROW []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0000784
name: forebrain hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the forebrain, typically resulting in decreased size" [GO:0048853]
synonym: "hypoplastic forebrain" EXACT []
synonym: "prosencephalon hypoplasia" EXACT []
is_a: MP:0012138 ! decreased forebrain size

[Term]
id: MP:0000785
name: telencephalon hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the telencephalon, typically resulting in decreased size" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "hypoplastic telencephalon" EXACT []
is_a: MP:0000787 ! abnormal telencephalon morphology

[Term]
id: MP:0000786
name: abnormal embryonic neuroepithelial layer differentiation
def: "abnormal or arrest of differentiation or patterning of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [PMID:9362461]
is_a: MP:0000913 ! abnormal brain development
is_a: MP:0004261 ! abnormal embryonic neuroepithelium morphology

[Term]
id: MP:0000787
name: abnormal telencephalon morphology
alt_id: MP:0000782
def: "any structural anomaly of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon" [https://orcid.org/0000-0002-6490-7723]
synonym: "telencephalon dysplasia" NARROW []
is_a: MP:0000783 ! abnormal forebrain morphology

[Term]
id: MP:0000788
name: abnormal cerebral cortex morphology
def: "any structural anomaly of thin layer of grey matter on the surface of the cerebral hemisphere that folds into gyri; it is responsible for intellectual faculties and higher mental functions" [MESH:A08.186.211.730.885.287.500]
synonym: "abnormal pallium morphology" EXACT []
synonym: "cerebral cortex dysplasia" NARROW []
synonym: "pallium dysplasia" NARROW []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000789
name: thickened cerebral cortex
def: "increased depth of the mantle covering the surface of the cerebral hemispheres" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0000790
name: abnormal stratification in cerebral cortex
def: "abnormal formation or pattern of the layers of the cerebral cortex" [https://orcid.org/0000-0003-3691-0324, J:64289]
synonym: "abnormal cerebral cortex stratification" EXACT []
synonym: "abnormal stratification in neocortex" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0000791
name: delaminated cerebral cortex
def: "splitting of the layers of the grey cellular mantle covering the surface of the brain" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9010203]
synonym: "delaminated neocortex" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0000792
name: abnormal cortical marginal zone morphology
def: "any structural anomaly of the developing superficial cortical layer located just under the pia matter" [https://orcid.org/0000-0003-3691-0324, PMID:1812236]
synonym: "abnormal MZ morphology" EXACT []
synonym: "cortical marginal zone dysplasia" NARROW []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0000794
name: abnormal parietal lobe morphology
def: "any structural anomaly of the upper central part of the cerebral hemisphere" [MESH:A08.186.211.730.885.287.500.670]
synonym: "parietal lobe dysplasia" NARROW []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000795
name: abnormal postcentral gyrus morphology
def: "any structural anomaly of the area of the parietal lobe that receives general sensation from the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "postcentral gyrus dysplasia" NARROW []
is_a: MP:0000794 ! abnormal parietal lobe morphology

[Term]
id: MP:0000796
name: abnormal sensory dissociation area morphology
def: "any structural anomaly of the area of the parietal lobe that integrates tactile and visual stimuli" [https://orcid.org/0000-0003-3691-0324]
synonym: "sensory dissociation area dysplasia" NARROW []
is_a: MP:0000794 ! abnormal parietal lobe morphology

[Term]
id: MP:0000797
name: abnormal supramarginal gyrus morphology
def: "any structural anomaly of the area of the frontal lobe that is involved in perception based on sensory stimuli" [https://orcid.org/0000-0003-3691-0324]
synonym: "supramarginal gyrus dysplasia" NARROW []
is_a: MP:0000794 ! abnormal parietal lobe morphology

[Term]
id: MP:0000798
name: abnormal frontal lobe morphology
def: "any structural anomaly of the anterior part of the cerebral hemisphere" [MESH:A08.186.211.730.885.287.500.270]
synonym: "frontal lobe dysplasia" NARROW []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000799
name: abnormal precentral gyrus morphology
def: "any structural anomaly of the area of the frontal lobe that contains the cell bodies of the primary motor pathways" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal primary motor area morphology" EXACT []
synonym: "precentral gyrus dysplasia" NARROW []
is_a: MP:0000798 ! abnormal frontal lobe morphology

[Term]
id: MP:0000800
name: abnormal supplemetal motor cortex morphology
def: "any structural anomaly of the area of the frontal lobe that is involved with integration of voluntary movements and with speech" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal prefrontal gyrus morphology" EXACT []
synonym: "abnormal supplementary motor/speech area morphology" EXACT []
synonym: "prefrontal gyrus dysplasia" NARROW []
is_a: MP:0000798 ! abnormal frontal lobe morphology

[Term]
id: MP:0000801
name: abnormal temporal lobe morphology
def: "any structural anomaly of the lower lateral part of the cerebral hemisphere" [MESH:A08.186.211.730.885.287.500.863]
synonym: "temporal lobe dysplasia" NARROW []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000802
name: abnormal superior temporal gyrus morphology
def: "any structural anomaly of one of three major convolutions of the external surface of the temporal lobe of the cerebral hemispheres that is uppermost and borders the lateral (sylvian) fissure, and contains the primary auditory cortex" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal first temporal convolution morphology" EXACT []
synonym: "abnormal gyrus temporalis superior morphology" EXACT []
synonym: "abnormal superior temporal convolution morphology" EXACT []
synonym: "superior temporal gyrus dysplasia" NARROW []
is_a: MP:0000801 ! abnormal temporal lobe morphology

[Term]
id: MP:0000803
name: abnormal transverse gyrus of Heschl morphology
def: "any structural anomaly of the area of the temporal lobe concerned with hearing" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal primary auditory area morphology" EXACT []
synonym: "transverse gyrus of Heschl dysplasia" NARROW []
is_a: MP:0004631 ! abnormal auditory cortex morphology

[Term]
id: MP:0000804
name: abnormal occipital lobe morphology
def: "any structural anomaly of the posterior part of the cerebral hemisphere" [MESH:A08.186.211.730.885.287.500.571]
synonym: "occipital lobe dysplasia" NARROW []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0000805
name: abnormal visual cortex morphology
def: "any structural anomaly of the area of the occipital cortex concerned with vision" [MESH:A08.186.211.730.885.287.500.571.735]
synonym: "abnormal striate cortex morphology" EXACT []
synonym: "striate cortex dysplasia" NARROW []
synonym: "visual cortex dysplasia" NARROW []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0000804 ! abnormal occipital lobe morphology

[Term]
id: MP:0000807
name: abnormal hippocampus morphology
alt_id: MP:0000806
alt_id: MP:0000810
def: "any structural anomaly of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6, PMID:9010203]
comment: The synonym abnormal hippocampal formation is a frequently used synonym in the literature for the hippocampus. It is unfortunate that it implies a developmental process. There is also a lack of consensus relating to terms describing the hippocampus and/or the adjacent cerebral cortex with the term hippocampus sometimes referring to the hippocampal formation (or region) and sometimes only to the Ammon gyrus (Ammon's horn). In this ontology, we have used hippocampus to mean the entire formation (region).
synonym: "abnormal hippocampal formation morphology" RELATED []
synonym: "abnormal hippocampal region" BROAD []
synonym: "abnormal hippocampus" BROAD []
synonym: "abnormal hippocampus region" BROAD []
synonym: "hippocampal defects" BROAD []
synonym: "hippocampus dysplasia" NARROW []
is_a: MP:0000801 ! abnormal temporal lobe morphology
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0000808
name: abnormal hippocampus development
def: "improper differentiation of the hippocampus" [MGI:tc]
synonym: "abnormal hippocampal development" EXACT []
synonym: "hippocampal dysgenesis" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
is_a: MP:0003232 ! abnormal forebrain development

[Term]
id: MP:0000809
name: absent hippocampus
def: "missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system" [ISBN:0-683-40008-8, PMID:10631168]
synonym: "absence of hippocampus" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0000811
name: hippocampal neuron degeneration
def: "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [J:72427, MGI:cml]
synonym: "degenerating hippocampal neurons" EXACT []
is_a: MP:0003224 ! neuron degeneration
is_a: MP:0009939 ! abnormal hippocampus neuron morphology

[Term]
id: MP:0000812
name: abnormal dentate gyrus morphology
def: "any structural anomaly of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9010203]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal area dentata morphology" EXACT []
synonym: "abnormal dentate gyrus of hippocampal formation morphology" EXACT []
synonym: "abnormal fascia dentata morphology" EXACT []
synonym: "dentate gyrus dysplasia" NARROW []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0000813
name: abnormal hippocampus layer morphology
def: "any structural anomaly of the layers of the laminar structure of the hippocampus" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal hippocampal laminar structure" EXACT []
synonym: "abnormal laminar structure of hippocampus" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0000814
name: absent dentate gyrus
def: "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [ISBN:0-683-40008-8, PMID:10631168]
synonym: "absence of dentate gyrus" EXACT []
is_a: MP:0000812 ! abnormal dentate gyrus morphology

[Term]
id: MP:0000815
name: abnormal Ammon gyrus morphology
def: "any structural anomaly of one or both of the two interlocking gyri of the hippocampus formation; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells" [ISBN:0-683-40008-8]
synonym: "abnormal Ammon horn morphology" EXACT []
synonym: "abnormal Ammon's horn morphology" EXACT []
synonym: "abnormal CA" BROAD []
synonym: "abnormal Cornu Ammonis morphology" EXACT []
synonym: "abnormal hippocampus proper morphology" EXACT []
synonym: "Ammon gyrus dysplasia" NARROW []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0000816
name: obsolete abnormal hippocampal molecular layer morphology
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hippocampal molecular layer" EXACT []
is_obsolete: true
replaced_by: MP:0008286

[Term]
id: MP:0000818
name: abnormal amygdala morphology
def: "any structural anomaly of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [ISBN:0-683-40008-8, MESH:A08.186.211.577.090]
synonym: "abnormal amygdaloid area morphology" EXACT []
synonym: "abnormal amygdaloid body morphology" EXACT []
synonym: "abnormal amygdaloid complex morphology" EXACT []
synonym: "abnormal amygdaloid nuclear complex morphology" EXACT []
synonym: "abnormal amygdaloid nuclear group morphology" EXACT []
synonym: "abnormal amygdaloid nucleus morphology" EXACT []
synonym: "amygdala dysplasia" NARROW []
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0000819
name: abnormal olfactory bulb morphology
alt_id: MP:0000943
def: "any structural anomaly of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [ISBN:0-683-40008-8, ISBN:0838580343]
synonym: "abnormal olfactory bulb" EXACT []
xref: MA:0000194
is_a: MP:0009944 ! abnormal olfactory lobe morphology

[Term]
id: MP:0000820
name: abnormal choroid plexus morphology
def: "any structural anomaly of the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain; choroid plexuses secrete cerebrospinal fluid (CSF) and act as a filtration system, removing metabolic waste, foreign substances, and excess neurotransmitters from the CSF" [http://medical-dictionary.thefreedictionary.com/plexus, https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:9362461]
synonym: "choroid plexus dysplasia" NARROW []
is_a: MP:0013306 ! abnormal tela choroidea morphology

[Term]
id: MP:0000821
name: choroid plexus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the choroid plexus, typically resulting in increased size" [http://medical-dictionary.thefreedictionary.com/plexus, https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
synonym: "hyperplastic choroid plexus" EXACT []
is_a: MP:0000820 ! abnormal choroid plexus morphology

[Term]
id: MP:0000822
name: abnormal brain ventricle morphology
def: "any structural anomaly of the system of four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [ISBN:0-683-40008-8]
synonym: "abnormal cerebral ventricle morphology" EXACT []
synonym: "abnormal ventricle" BROAD []
synonym: "brain ventricle dysplasia" NARROW []
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0000823
name: abnormal lateral ventricle morphology
def: "any structural anomaly of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:cwg]
synonym: "abnormal lateral ventricles" BROAD []
synonym: "abnormal ventricle of cerebral hemisphere morphology" EXACT []
synonym: "abnormal ventriculus lateralis morphology" EXACT []
synonym: "lateral ventricle dysplasia" NARROW []
is_a: MP:0000787 ! abnormal telencephalon morphology
is_a: MP:0000822 ! abnormal brain ventricle morphology

[Term]
id: MP:0000825
name: dilated lateral ventricle
alt_id: MP:0000824
def: "the luminal space of one or both lateral ventricles is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, MESH:A08.186.211.276.650, PMID:9010203]
synonym: "dilated lateral ventricles" EXACT []
synonym: "dilated telencephalic ventricle" EXACT []
synonym: "dilated telencephalic ventricles" EXACT []
synonym: "dilated ventricle of cerebral hemisphere" EXACT []
synonym: "dilated ventriculus lateralis" EXACT []
synonym: "lateral ventricle dilation" EXACT []
synonym: "telencephalic ventricle dilation" EXACT []
synonym: "ventriculus lateralis dilation" EXACT []
is_a: MP:0000823 ! abnormal lateral ventricle morphology
is_a: MP:0012676 ! dilated brain ventricle

[Term]
id: MP:0000826
name: abnormal third ventricle morphology
def: "any structural anomaly of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:cwg]
synonym: "abnormal 3rd ventricle morphology" EXACT []
synonym: "abnormal ventriculus tertius morphology" EXACT []
synonym: "third ventricle dysplasia" NARROW []
is_a: MP:0000822 ! abnormal brain ventricle morphology
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000827
name: dilated third ventricle
def: "the luminal space of the third ventricle is increased in volume or area, usually with an increase in contained fluid, in the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:cwg]
synonym: "3rd ventricle dilation" EXACT []
synonym: "dilated 3rd ventricle" EXACT []
synonym: "dilated third ventricles" EXACT []
synonym: "dilated ventricle of diencephalon" EXACT []
synonym: "dilated ventriculus tertius" EXACT []
synonym: "third ventricle dilation" RELATED []
synonym: "ventriculus tertius dilation" EXACT []
is_a: MP:0000826 ! abnormal third ventricle morphology
is_a: MP:0012676 ! dilated brain ventricle

[Term]
id: MP:0000828
name: abnormal fourth ventricle morphology
def: "any structural anomaly of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:cwg]
synonym: "abnormal 4th ventricle morphology" EXACT []
synonym: "abnormal IVth ventricle morphology" EXACT []
synonym: "abnormal rhombencephalic ventricle morphology" EXACT []
synonym: "abnormal ventricle of rhombencephalon morphology" EXACT []
synonym: "abnormal ventriculus quartus morphology" EXACT []
synonym: "fourth ventricle dysplasia" NARROW []
is_a: MP:0000822 ! abnormal brain ventricle morphology
is_a: MP:0000841 ! abnormal hindbrain morphology

[Term]
id: MP:0000829
name: dilated fourth ventricle
def: "the luminal space of the fourth ventricle is increased in volume or area, usually with an increase in contained fluid, in the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:cwg]
synonym: "4th ventricle dilation" EXACT []
synonym: "dilated 4th ventricle" EXACT []
synonym: "dilated 4th ventricles" EXACT []
synonym: "dilated fourth ventricles" EXACT []
synonym: "dilated IVth ventricle" EXACT []
synonym: "dilated IVth ventricles" EXACT []
synonym: "dilated rhombencephalic ventricle" EXACT []
synonym: "dilated rhombencephalic ventricles" EXACT []
synonym: "dilated ventricle of rhombencephalon" EXACT []
synonym: "dilated ventriculus quartus" EXACT []
synonym: "fourth ventricle dilation" EXACT []
synonym: "IVth ventricle dilation" EXACT []
synonym: "rhombencephalic ventricle dilation" EXACT []
synonym: "ventriculus quartus dilation" EXACT []
is_a: MP:0000828 ! abnormal fourth ventricle morphology
is_a: MP:0012676 ! dilated brain ventricle

[Term]
id: MP:0000830
name: abnormal diencephalon morphology
def: "any structural anomaly of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [ISBN:0838580343, MESH:A08.186.211.730.317]
synonym: "abnormal betweenbrain morphology" EXACT []
synonym: "abnormal interbrain morphology" EXACT []
synonym: "abnormal thalamencephalon morphology" EXACT []
synonym: "diencephalon dysplasia" NARROW []
is_a: MP:0000783 ! abnormal forebrain morphology

[Term]
id: MP:0000831
name: diencephalon hyperplasia
def: "increase in the number of normal cells in normal arrangement in the diencephalon, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "betweenbrain hyperplasia" EXACT []
synonym: "hyperplastic diencephalon" EXACT []
synonym: "interbrain hyperplasia" RELATED []
synonym: "thalamencephalon hyperplasia" EXACT []
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000832
name: abnormal thalamus morphology
def: "any structural anomaly of the large ovoid mass of paired bodies containing mostly grey matter and forming part of the lateral wall of the third ventricle of the brain" [ISBN:0-683-40008-8, MESH:A08.186.211.730.317.826]
synonym: "thalamus dysplasia" NARROW []
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000833
name: thalamus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the thalamus, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic thalamus" EXACT []
is_a: MP:0020526 ! enlarged thalamus

[Term]
id: MP:0000834
name: abnormal subthalamus morphology
def: "any structural anomaly of the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis" [ISBN:0-683-40008-8, MESH:A08.186.211.730.317.800]
synonym: "abnormal ventral thalamus" EXACT []
synonym: "subthalamus dysplasia" NARROW []
synonym: "ventral thalamus dysplasia" NARROW []
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000835
name: abnormal subthalamic nucleus morphology
def: "any structural anomaly of the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function" [ISBN:0-683-40008-8, MESH:A08.186.211.730.317.800.800]
synonym: "abnormal corpus luysi morphology" EXACT []
synonym: "subthalamic nucleus dysplasia" NARROW []
is_a: MP:0000834 ! abnormal subthalamus morphology
is_a: MP:0006007 ! abnormal basal ganglion morphology

[Term]
id: MP:0000836
name: abnormal substantia nigra morphology
def: "any structural anomaly of the layer of grey substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal locus niger morphology" EXACT []
synonym: "abnormal nucleus niger morphology" EXACT []
synonym: "substantia nigra dysplasia" NARROW []
is_a: MP:0000897 ! abnormal midbrain morphology
is_a: MP:0006007 ! abnormal basal ganglion morphology

[Term]
id: MP:0000837
name: abnormal hypothalamus morphology
def: "any structural anomaly of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MESH:A08.186.211.464.482]
synonym: "hypothalamus dysplasia" NARROW []
is_a: MP:0000830 ! abnormal diencephalon morphology
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0000838
name: obsolete abnormal pituitary afferents
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000839
name: hypothalamus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the hypothalamus, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
synonym: "hyperplastic hypothalamus" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology

[Term]
id: MP:0000840
name: abnormal epithalamus morphology
def: "any structural anomaly of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle" [ISBN:0-683-40008-8, MESH:A08.186.211.464.200]
synonym: "epithalamus dysplasia" NARROW []
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0000841
name: abnormal hindbrain morphology
def: "any structural anomaly of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal rhombencephalon morphology" RELATED []
synonym: "hindbrain dysplasia" NARROW []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0000842
name: absent superior olivary complex
def: "missing nucleus of neurons on the dorsal part of the lateral surface of the pons; it normally receives projection fibers from the cochlear nuclei and is prominently involved in spatial localization of sound" [ISBN:0-683-40008-8, PMID:1346922]
is_a: MP:0000848 ! abnormal pons morphology

[Term]
id: MP:0000843
name: absent facial nuclei
def: "missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle" [ISBN:0-683-40008-8, PMID:1346922]
is_a: MP:0000909 ! abnormal facial motor nucleus morphology

[Term]
id: MP:0000844
name: abnormal pontine flexure morphology
def: "any structural anomaly of the dorsally concave bend of the embryonic rhombencephalon that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and myelencephalon in the embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal (embryonic) hindbrain flexure morphology" EXACT []
synonym: "abnormal basicranial flexure morphology" EXACT []
synonym: "abnormal pontal flexure morphology" EXACT []
synonym: "abnormal transverse rhombencephalic flexure morphology" EXACT []
is_a: MP:0000841 ! abnormal hindbrain morphology
is_a: MP:0006108 ! abnormal hindbrain development

[Term]
id: MP:0000846
name: abnormal medulla oblongata morphology
alt_id: MP:0000845
def: "any structural anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [ISBN:0838580343]
synonym: "abnormal myelencephalon morphology" EXACT []
synonym: "medulla oblongata dysplasia" NARROW []
synonym: "myelencephalon dysplasia" NARROW []
is_a: MP:0000841 ! abnormal hindbrain morphology
is_a: MP:0005277 ! abnormal brainstem morphology

[Term]
id: MP:0000847
name: abnormal metencephalon morphology
def: "any structural anomaly of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the cerebellum and the pons Varolii" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal anterior hindbrain morphology" EXACT []
synonym: "abnormal anterior rhombencephalon morphology" EXACT []
synonym: "abnormal epencephalon morphology" EXACT []
synonym: "abnormal rostral hindbrain morphology" EXACT []
synonym: "abnormal rostral rhombencephalon morphology" EXACT []
synonym: "metencephalon dysplasia" NARROW []
is_a: MP:0000841 ! abnormal hindbrain morphology

[Term]
id: MP:0000848
name: abnormal pons morphology
def: "any structural anomaly of the band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [ISBN:0-683-40008-8, ISBN:0838580343, PMID:1346922]
synonym: "abnormal pons Varolii morphology" EXACT []
synonym: "pons dysplasia" NARROW []
is_a: MP:0000847 ! abnormal metencephalon morphology
is_a: MP:0005277 ! abnormal brainstem morphology

[Term]
id: MP:0000849
name: abnormal cerebellum morphology
def: "any structural anomaly of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [ISBN:0838580343, PMID:9778510]
synonym: "cerebellar dysplasia" NARROW []
synonym: "cerebellum dysplasia" NARROW []
is_a: MP:0000847 ! abnormal metencephalon morphology

[Term]
id: MP:0000850
name: absent cerebellum
def: "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [ISBN:0-683-40008-8, PMID:7925010]
synonym: "absence of cerebellum" EXACT []
is_a: MP:0000849 ! abnormal cerebellum morphology

[Term]
id: MP:0000851
name: cerebellum hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the cerebellum, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, PMID:9362461]
synonym: "cerebellar hypoplasia" EXACT []
synonym: "hypoplastic cerebellum" EXACT []
synonym: "reduced cerebellum cellularity" EXACT []
is_a: MP:0000852 ! small cerebellum

[Term]
id: MP:0000852
name: small cerebellum
def: "reduced size of cerebellum" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cerebellum size" EXACT []
synonym: "reduced cerebellum size" EXACT []
is_a: MP:0000849 ! abnormal cerebellum morphology

[Term]
id: MP:0000853
name: absent cerebellar foliation
def: "missing small branches of the cerebellar lobules" [ISBN:0838580343, MGI:tc, PMID:10716451]
synonym: "absence of cerebellum foliation" EXACT []
synonym: "lack of cerebellar foliation" EXACT []
synonym: "lack of cerebellum foliation" EXACT []
synonym: "loss of cerebellar foliation" EXACT []
synonym: "loss of cerebellum foliation" EXACT []
is_a: MP:0000857 ! abnormal cerebellar foliation

[Term]
id: MP:0000854
name: abnormal cerebellum development
def: "aberrant or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellar development" EXACT []
is_a: MP:0000849 ! abnormal cerebellum morphology
is_a: MP:0006108 ! abnormal hindbrain development

[Term]
id: MP:0000855
name: accelerated formation of intralobular fissures
def: "formation of the major fissures of the cerebellum earlier in development than normal" [J:56546]
is_a: MP:0000854 ! abnormal cerebellum development

[Term]
id: MP:0000856
name: abnormal cerebellar plate morphology
def: "any structural anomaly of the embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium" [PMID:9362461]
synonym: "cerebellar plate dysplasia" NARROW []
is_a: MP:0000854 ! abnormal cerebellum development

[Term]
id: MP:0000857
name: abnormal cerebellar foliation
def: "any anomaly of the pattern of the ten cerebellar lobules; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres and the intermediate zone that separates the vermis from the lateral hemispheres; in addition, each of the ten basic lobules can be subdivided into sublobules but strain and species differences are reported" [ISBN:0838580343, PMID:17506688]
is_a: MP:0000854 ! abnormal cerebellum development
is_a: MP:0009964 ! abnormal cerebellum lobule morphology

[Term]
id: MP:0000858
name: abnormal metastatic potential
def: "altered likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "alteration in metastasis potential" EXACT []
synonym: "altered metastatic potential" EXACT []
synonym: "change in metastasis potential" EXACT []
synonym: "change in potential to develop metastases" EXACT []
is_a: MP:0010639 ! abnormal tumor pathology

[Term]
id: MP:0000859
name: abnormal somatosensory cortex morphology
def: "any structural anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [ISBN:0-683-40008-8, MESH:A08.186.211.730.885.287.500.670.675]
synonym: "abnormal somatic sensory cortex morphology" EXACT []
synonym: "abnormal somesthetic area morphology" EXACT []
synonym: "somatosensory cortex dysplasia" NARROW []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0000794 ! abnormal parietal lobe morphology

[Term]
id: MP:0000860
name: abnormal primary somatosensory cortex morphology
def: "any structural anomaly of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [ISBN:0838580343]
synonym: "abnormal primary somatic sensory cortex morphology" EXACT []
is_a: MP:0000859 ! abnormal somatosensory cortex morphology

[Term]
id: MP:0000861
name: disorganized barrel cortex
def: "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [ISBN:0838580343, J:64064]
synonym: "disorganised barrel cortex" EXACT []
is_a: MP:0003989 ! abnormal barrel cortex morphology

[Term]
id: MP:0000862
name: absent barrels in primary somatosensory cortex
def: "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [ISBN:0838580343]
synonym: "absence of barrels in primary somatosensory cortex" EXACT []
is_a: MP:0003989 ! abnormal barrel cortex morphology

[Term]
id: MP:0000863
name: abnormal secondary somatosensory cortex morphology
def: "any structural anomaly of the area of the upper bank of the lateral sulcus that is involved in somatic sensation" [ISBN:0838580343]
synonym: "abnormal secondary somatic sensory cortex morphology" EXACT []
is_a: MP:0000859 ! abnormal somatosensory cortex morphology

[Term]
id: MP:0000864
name: abnormal cerebellum vermis morphology
def: "any structural anomaly of the narrow medial zone between the two hemispheres of the cerebellum that is delimited by two longitudinal furrows; it may be continuous with the cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissues in others (e.g., ventrally); it receives inputs from the spinocerebellar tracts which carry to the vermis information on the position and balance of the torso, and it sends projections to the fastigial nucleus of the cerebellum, which then sends output to the vestibular nuclei" [ISBN:0-683-40008-8, ISBN:0838580343, NLX:birnlex_1106, PMID:10742104]
synonym: "abnormal cerebellar vermis morphology" EXACT []
synonym: "abnormal spinocerebellum morphology vermis part" EXACT []
synonym: "abnormal vermis morphology" EXACT []
synonym: "cerebellum vermis dysplasia" NARROW []
xref: MA:0000202
is_a: MP:0004097 ! abnormal cerebellar cortex morphology

[Term]
id: MP:0000865
name: absent cerebellum vermis
def: "missing narrow middle zone between the two hemispheres of the cerebellum" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "absent spinocerebellum morphology vermis part" RELATED []
synonym: "absent vermis" RELATED []
is_a: MP:0000864 ! abnormal cerebellum vermis morphology

[Term]
id: MP:0000866
name: cerebellum vermis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the cerebellum vermis, typically resulting in decreased size" [PMID:10742104]
synonym: "cerebellar vermal hypoplasia" EXACT []
synonym: "cerebellar vermis hypoplasia" EXACT []
synonym: "hypoplastic cerebellar vermis" EXACT []
synonym: "hypoplastic cerebellum vermis" EXACT []
synonym: "hypoplastic vermis" EXACT []
synonym: "vermis hypoplasia" EXACT []
is_a: MP:0000864 ! abnormal cerebellum vermis morphology

[Term]
id: MP:0000867
name: abnormal cerebellum anterior vermis morphology
def: "any structural anomaly of the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located anterior to the primary fissure" [ISBN:0-683-40008-8]
synonym: "abnormal anterior vermis morphology" EXACT []
synonym: "abnormal rostral vermis morphology" EXACT []
synonym: "cerebellum anterior vermis dysplasia" NARROW []
is_a: MP:0000864 ! abnormal cerebellum vermis morphology
is_a: MP:0009960 ! abnormal cerebellum anterior lobe morphology

[Term]
id: MP:0000868
name: decreased anterior vermis size
def: "smaller appearance of the narrow middle zone between the two hemispheres of the anterior lobe of the cerebellum" [ISBN:0-683-40008-8]
synonym: "decreased size of anterior vermis" EXACT []
synonym: "reduced anterior vermis size" EXACT []
synonym: "small anterior vermis" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology

[Term]
id: MP:0000869
name: abnormal cerebellum posterior vermis morphology
def: "any structural anomaly of the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located posterior to the primary fissure" [ISBN:0-683-40008-8, PMID:10742104]
synonym: "abnormal caudal vermis morphology" EXACT []
synonym: "abnormal inferior vermis morphology" EXACT []
synonym: "abnormal posterior vermis morphology" EXACT []
synonym: "cerebellum posterior vermis dysplasia" NARROW []
is_a: MP:0000864 ! abnormal cerebellum vermis morphology
is_a: MP:0009962 ! abnormal cerebellum posterior lobe morphology

[Term]
id: MP:0000870
name: absent cerebellum vermis lobule VIII
def: "missing part of the inferior vermis of the cerebellum (vermis lobule VIII)" [ISBN:0-683-40008-8, PMID:10742104]
synonym: "absence of vermal pyramis" EXACT []
synonym: "absent cerebellar pyramid" EXACT []
synonym: "absent pyramid of vermis" EXACT []
synonym: "absent pyramis of cerebellum" EXACT []
synonym: "absent vermal pyramis" EXACT []
is_a: MP:0009996 ! abnormal cerebellum vermis lobule VIII morphology

[Term]
id: MP:0000871
name: absent cerebellum vermis lobule IX
def: "missing triangular elevation on the vermis of the cerebellum" [ISBN:0-683-40008-8, PMID:10742104]
synonym: "absence of vermal uvula" EXACT []
synonym: "absent vermal uvula" EXACT []
is_a: MP:0009992 ! abnormal cerebellum vermis lobule IX morphology

[Term]
id: MP:0000872
name: abnormal cerebellum external granule cell layer morphology
def: "any structural anomaly of the transient layer of the cerebellar cortex present during development which is composed of the dividing and migrating granule cells" [MGI:tc]
synonym: "abnormal EGL" BROAD []
synonym: "abnormal external germinal layer morphology" EXACT []
synonym: "abnormal external granule cell layer morphology" BROAD []
synonym: "abnormal external granule layer morphology" EXACT []
is_a: MP:0000854 ! abnormal cerebellum development

[Term]
id: MP:0000873
name: thin external granule cell layer
def: "reduced thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells" [MGI:tc, PMID:10716451]
synonym: "thin EGL" EXACT []
synonym: "thin external germinal layer" EXACT []
synonym: "thin external granule layer" EXACT []
is_a: MP:0000872 ! abnormal cerebellum external granule cell layer morphology

[Term]
id: MP:0000874
name: irregular external granule cell layer thickness
def: "uneven thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells" [MGI:tc]
synonym: "irregular EGL" EXACT []
synonym: "irregular external germinal layer" EXACT []
synonym: "irregular external granule layer" EXACT []
is_a: MP:0000872 ! abnormal cerebellum external granule cell layer morphology

[Term]
id: MP:0000875
name: abnormal cerebellar Purkinje cell layer
def: "any structural anomaly of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [ISBN:0-683-40008-8]
synonym: "abnormal Purkinje cell layer" EXACT []
is_a: MP:0009956 ! abnormal cerebellar layer morphology

[Term]
id: MP:0000876
name: Purkinje cell degeneration
def: "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0003224 ! neuron degeneration

[Term]
id: MP:0000877
name: abnormal Purkinje cell morphology
def: "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [ISBN:0838580343]
synonym: "abnormal Purkinje cells" BROAD []
synonym: "abnormal Purkinje neuron morphology" EXACT []
is_a: MP:0000875 ! abnormal cerebellar Purkinje cell layer
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0000878
name: abnormal Purkinje cell number
def: "different from average number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [ISBN:0-683-40008-8]
is_a: MP:0000877 ! abnormal Purkinje cell morphology

[Term]
id: MP:0000879
name: increased Purkinje cell number
alt_id: MP:0000325
def: "greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0000878 ! abnormal Purkinje cell number
is_a: MP:0008947 ! increased neuron number

[Term]
id: MP:0000880
name: decreased Purkinje cell number
alt_id: MP:0000337
def: "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "reduced Purkinje cell number" EXACT []
is_a: MP:0000878 ! abnormal Purkinje cell number
is_a: MP:0008948 ! decreased neuron number

[Term]
id: MP:0000881
name: obsolete Abnormal Purkinje Cell Size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000882
name: obsolete Increased Purkinje Cell Size dup.
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000883
name: obsolete Decreased Purkinje Cell Size dup.
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000884
name: delaminated Purkinje cell layer
def: "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [ISBN:0-683-40008-8, PMID:10742104]
is_a: MP:0000875 ! abnormal cerebellar Purkinje cell layer

[Term]
id: MP:0000885
name: ectopic Purkinje cell
def: "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, PMID:10716451]
synonym: "heterotopic Purkinje cell" EXACT []
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0011723 ! ectopic neuron

[Term]
id: MP:0000886
name: abnormal cerebellar granule layer morphology
def: "any structural anomaly of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [ISBN:0-683-40008-8, ISBN:0838580343]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal granule layer morphology" EXACT []
synonym: "abnormal IGL" BROAD []
synonym: "abnormal internal granule cell layer morphology" EXACT []
synonym: "abnormal internal granule layer morphology" EXACT []
is_a: MP:0009956 ! abnormal cerebellar layer morphology

[Term]
id: MP:0000887
name: delaminated cerebellar granule layer
def: "splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells" [ISBN:0-683-40008-8, PMID:10742104]
synonym: "delaminated IGL" EXACT []
synonym: "delaminated internal granule layer" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0000888
name: absent cerebellar granule layer
def: "absence of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [ISBN:0-683-40008-8, ISBN:0838580343]
subset: IMPC
subset: Sanger_Terms
synonym: "absent IGL" EXACT []
synonym: "absent internal granule layer" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0000889
name: abnormal cerebellar molecular layer
def: "any structural anomaly of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [ISBN:0-683-40008-8, PMID:9010203]
synonym: "abnormal molecular layer" EXACT []
is_a: MP:0009956 ! abnormal cerebellar layer morphology

[Term]
id: MP:0000890
name: thin cerebellar molecular layer
def: "reduced width of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [ISBN:0-683-40008-8, PMID:9010203]
synonym: "decreased cerebellar molecular layer width" EXACT []
is_a: MP:0000889 ! abnormal cerebellar molecular layer

[Term]
id: MP:0000891
name: obsolete Abnormal Thickness of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000892
name: obsolete Increased Thickness of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000893
name: obsolete Decreased Thickness of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000894
name: obsolete Abnormal Cell Number of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000895
name: obsolete Increased Cell Number of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000896
name: obsolete Decreased Cell Number of Molecular Layer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0000897
name: abnormal midbrain morphology
def: "any structural anomaly associated with the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [ISBN:0838580343]
synonym: "abnormal mesencephalon morphology" EXACT []
synonym: "mesencephalon dysplasia" NARROW []
synonym: "midbrain dysplasia" NARROW []
is_a: MP:0005277 ! abnormal brainstem morphology

[Term]
id: MP:0000898
name: midbrain hyperplasia
def: "increase in the number of normal cells in normal arrangement in the brain region derived from the middle of the three cerebral vesicles of the embryo, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperplastic midbrain" EXACT []
synonym: "mesencephalon hyperplasia" EXACT []
is_a: MP:0012091 ! increased midbrain size

[Term]
id: MP:0000899
name: abnormal corpora quadrigemina morphology
def: "any structural anomaly of the inferior and superior colliculus" [PMID:9778510]
synonym: "abnormal colliculi morphology" EXACT []
synonym: "abnormal colliculus morphology" RELATED []
synonym: "abnormal quadrigeminal body morphology" EXACT []
synonym: "corpora quadrigemina dysplasia" NARROW []
is_a: MP:0006104 ! abnormal tectum morphology

[Term]
id: MP:0000900
name: decreased colliculi size
def: "smaller inferior and superior colliculus" [ISBN:0-683-40008-8, PMID:7925010]
synonym: "decreased size of colliculi" EXACT []
synonym: "reduced colliculi size" EXACT []
synonym: "reduced size of colliculi" EXACT []
is_a: MP:0000899 ! abnormal corpora quadrigemina morphology

[Term]
id: MP:0000901
name: abnormal position of colliculi
def: "positional abnormality of the inferior and superior colliculus" [J:57538]
synonym: "altered position of colliculi" EXACT []
is_a: MP:0000899 ! abnormal corpora quadrigemina morphology

[Term]
id: MP:0000904
name: abnormal superior colliculus morphology
def: "any structural anomaly of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [ISBN:0-683-40008-8]
synonym: "abnormal anterior quadrigeminal body morphology" EXACT []
synonym: "abnormal corpora quadrigeminum posterius anterius morphology" EXACT []
is_a: MP:0000899 ! abnormal corpora quadrigemina morphology

[Term]
id: MP:0000905
name: increased superior colliculus size
def: "enlargement of the paired superior eminence of the mesencephalic tectum" [ISBN:0-683-40008-8, J:57538]
synonym: "increased anterior quadrigeminal body size" EXACT []
synonym: "increased corpora quadrigeminum posterius anterius size" EXACT []
synonym: "increased size of superior colliculus" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology

[Term]
id: MP:0000906
name: abnormal trigeminal V mesencephalic nucleus morphology
def: "any structural anomaly of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [ISBN:0-683-40008-8]
synonym: "abnormal mesencephalic trigeminal nucleus morphology" EXACT []
xref: MA:0001057
is_a: MP:0000897 ! abnormal midbrain morphology

[Term]
id: MP:0000907
name: small mesencephalic trigeminal nucleus
def: "reduced size of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0000906 ! abnormal trigeminal V mesencephalic nucleus morphology

[Term]
id: MP:0000908
name: absent mesencephalic trigeminal nucleus
def: "missing group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [ISBN:0-683-40008-8, PMID:7958926]
is_a: MP:0000906 ! abnormal trigeminal V mesencephalic nucleus morphology

[Term]
id: MP:0000909
name: abnormal facial motor nucleus morphology
def: "any structural anomaly of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [ISBN:0838580343]
synonym: "abnormal motor nucleus, facial" EXACT []
is_a: MP:0000848 ! abnormal pons morphology

[Term]
id: MP:0000910
name: small facial motor nucleus
def: "reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [ISBN:0838580343, J:56847]
synonym: "decreased facial motor nucleus size" EXACT []
synonym: "small motor nucleus, facial" EXACT []
is_a: MP:0000909 ! abnormal facial motor nucleus morphology

[Term]
id: MP:0000911
name: abnormal trigeminal motor nucleus morphology
def: "any structural anomaly of the group of motor neurons innervating the muscles of mastication" [ISBN:0-683-40008-8]
synonym: "abnormal motor nucleus, trigeminal morphology" EXACT []
is_a: MP:0000848 ! abnormal pons morphology

[Term]
id: MP:0000912
name: small trigeminal motor nucleus
def: "reduced size of the group of motor neurons innervating the muscles of mastication" [ISBN:0-683-40008-8, J:18984]
synonym: "decreased trigeminal motor nucleus size" EXACT []
synonym: "small motor nucleus, trigeminal" EXACT []
is_a: MP:0000911 ! abnormal trigeminal motor nucleus morphology

[Term]
id: MP:0000913
name: abnormal brain development
alt_id: MP:0001888
def: "aberrant or incomplete differentiation of the brain" [https://orcid.org/0000-0003-3691-0324, PMID:9753320]
subset: IMPC_Prenatal
synonym: "brain development abnormalities" EXACT []
xref: GO:0007420
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0000914
name: exencephaly
def: "neurocranial defects resulting in exposure or extrusion of the brain" [ISBN:0-683-40008-8, PMID:9753320]
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "cranial hernia" EXACT []
synonym: "exencephalia" EXACT []
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0000917
name: obstructive hydrocephaly
alt_id: MP:0001892
def: "hydrocephaly due to a block in cerebrospinal fluid flow in the ventricular system" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "non-communicating hydrocephalus" EXACT []
synonym: "non-communicating hydrocephaly" EXACT []
synonym: "noncommunicating hydrocephalus" EXACT []
synonym: "noncommunicating hydrocephaly" EXACT []
synonym: "obstructive hydrocephalus" EXACT []
is_a: MP:0001891 ! hydrocephaly

[Term]
id: MP:0000919
name: cranioschisis
def: "incomplete closure of the skull, usually congenital" [ISBN:0-683-40008-8]
is_a: MP:0000438 ! abnormal cranium morphology

[Term]
id: MP:0000920
name: abnormal myelination
alt_id: MP:0001894
alt_id: MP:0010051
def: "any anomaly in the process by which myelin sheaths are formed and maintained around neurons; oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane" [GO:0042552, https://orcid.org/0000-0003-3691-0324]
synonym: "absence of myelination" NARROW []
synonym: "absent myelination" NARROW []
synonym: "altered myelination" EXACT []
synonym: "myelination abnormalities" EXACT []
synonym: "myelination defect" EXACT []
xref: GO:0042552
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0000921
name: demyelination
alt_id: MP:0010049
def: "abnormal degeneration or destruction of the myelin sheath that results in the partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract" [https://orcid.org/0000-0003-3691-0324]
comment: Demyelination is a term used to describe the destruction of the myelin sheath that surrounds axonal fibres. This is caused by diseases that damage the myelin sheath or the cells that form it.
synonym: "myelin degeneration" EXACT []
synonym: "myelin destruction" EXACT []
is_a: MP:0000920 ! abnormal myelination

[Term]
id: MP:0000923
name: abnormal roof plate morphology
def: "any structural anomaly of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline" [https://orcid.org/0000-0002-6490-7723]
synonym: "roof plate abnormalities" BROAD []
synonym: "roof plate dysplasia" NARROW []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0000924
name: absent roof plate
def: "absence of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of roof plate" EXACT []
is_a: MP:0000923 ! abnormal roof plate morphology

[Term]
id: MP:0000925
name: abnormal floor plate morphology
def: "any structural anomaly of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [UBERON:0003079]
synonym: "abnormal floorplate morphology" EXACT []
synonym: "floor plate abnormalities" BROAD []
synonym: "floor plate dysplasia" NARROW []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0000926
name: absent floor plate
def: "absence of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [UBERON:0003079]
synonym: "absent floorplate" EXACT []
is_a: MP:0000925 ! abnormal floor plate morphology

[Term]
id: MP:0000927
name: small floor plate
def: "reduced size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [UBERON:0003079]
synonym: "decreased floor plate size" EXACT []
synonym: "reduced floor plate size" EXACT []
synonym: "small floorplate" EXACT []
is_a: MP:0000925 ! abnormal floor plate morphology

[Term]
id: MP:0000928
name: incomplete rostral neuropore closure
def: "arrest of the fusion of the cephalic neural folds" [https://orcid.org/0000-0002-6490-7723]
comment: Head fold is properly used to describe the rostrally located, crescent shaped fold of the embryonic disc around the future foregut. However, it is often (and incorrectly) used as a synonym for the ventrally located cephalic neural folds. Take care to select the correct term.
synonym: "incomplete anterior cephalic closure" EXACT []
synonym: "incomplete cephalic closure" EXACT []
synonym: "incomplete cranial neural fold fusion" EXACT []
synonym: "incomplete head fold fusion" BROAD []
synonym: "incomplete headfold fusion" RELATED []
synonym: "incomplete rostral neural tube closure" RELATED []
synonym: "open anterior neuropore" EXACT []
is_a: MP:0003720 ! abnormal neural tube closure
is_a: MP:0012543 ! abnormal rostral neuropore morphology

[Term]
id: MP:0000929
name: open neural tube
alt_id: MP:0000931
alt_id: MP:0005436
def: "failure of completion of the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline" [https://orcid.org/0000-0003-3691-0324, J:62571, PMID:9949198]
synonym: "failure of neural tube closure" EXACT []
synonym: "hydrocele spinalis" EXACT []
synonym: "schistorrhachis" EXACT []
synonym: "spina bifida" BROAD []
is_a: MP:0003720 ! abnormal neural tube closure

[Term]
id: MP:0000930
name: wavy neural tube
def: "undulations in the embryonic neural tube" [J:37888]
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0000932
name: absent notochord
def: "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8]
synonym: "absence of notochord" EXACT []
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0000933
name: abnormal rhombomere morphology
def: "any structural anomaly of any of the transiently divided segments of the developing neural tube of vertebrate embryos found within the hindbrain region in the area that will eventually become the rhombencephalon; the rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:1346922, UBERON:0001892]
synonym: "abnormal rhombomeres" BROAD []
synonym: "rhombomere dysplasia" NARROW []
is_a: MP:0003208 ! abnormal neuromere morphology
is_a: MP:0006108 ! abnormal hindbrain development

[Term]
id: MP:0000934
name: abnormal telencephalon development
def: "anomaly in the progression of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000787 ! abnormal telencephalon morphology
is_a: MP:0003232 ! abnormal forebrain development

[Term]
id: MP:0000935
name: abnormal folding of telencephalic vesicles
def: "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0000936
name: small embryonic telencephalon
def: "reduced size of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
synonym: "small telencephalic vesicles" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0000937
name: abnormal motor neuron morphology
def: "any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal motoneuron morphology" EXACT []
synonym: "abnormal motor neurons" BROAD []
synonym: "motor neuron abnormalities" BROAD []
synonym: "motor neuron dysplasia" NARROW []
is_a: MP:0002882 ! abnormal neuron morphology
is_a: MP:0008503 ! abnormal spinal cord grey matter morphology

[Term]
id: MP:0000938
name: motor neuron degeneration
def: "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses" [https://orcid.org/0000-0003-3691-0324]
synonym: "loss of motor neurons" RELATED []
synonym: "motoneuron degeneration" EXACT []
is_a: MP:0000937 ! abnormal motor neuron morphology
is_a: MP:0003224 ! neuron degeneration

[Term]
id: MP:0000939
name: decreased motor neuron number
def: "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased motoneuron number" EXACT []
synonym: "reduced motor neuron number" EXACT []
is_a: MP:0000937 ! abnormal motor neuron morphology
is_a: MP:0008948 ! decreased neuron number

[Term]
id: MP:0000940
name: abnormal motor neuron innervation pattern
def: "any changes in the placement, morphology or number of motor nerve fibers to an effector motor tissue, or failure of refinement of neuronal connections during development" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal motoneuron innervation" EXACT []
synonym: "abnormal motor neuron projections" EXACT []
is_a: MP:0000937 ! abnormal motor neuron morphology
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0000941
name: obsolete failure of motor neuron target finding
def: "OBSOLETE. failure of an innervating motor neuron to stop at target site and form terminal arbors" []
synonym: "failure of motoneuron target finding" EXACT []
is_obsolete: true
consider: MP:0000940

[Term]
id: MP:0000942
name: obsolete excessive motor neuron axon growth
def: "OBSOLETE. innervating motor neuron projections grow past typical endplate target and extend to myotendenous ends of muscle" []
synonym: "excessive motoneuron axon growth" EXACT []
synonym: "excessive motor neuron growth" EXACT []
is_obsolete: true
consider: MP:0000940

[Term]
id: MP:0000944
name: obsolete Reduced Olfactory mitral Cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0009954

[Term]
id: MP:0000947
name: convulsive seizures
alt_id: MP:0001494
def: "seizures characterized by uncontrolled motor activity" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "convulsions" EXACT []
synonym: "Convulsive" EXACT []
is_a: MP:0002064 ! seizures

[Term]
id: MP:0000948
name: nonconvulsive seizures
alt_id: MP:0001495
def: "seizures without uncontrolled motor activity, but with impairment of consciousness" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "Nonconvulsive" EXACT []
is_a: MP:0002064 ! seizures

[Term]
id: MP:0000950
name: abnormal seizure response to pharmacological agent
alt_id: MP:0001497
def: "anomaly in the seizure activity response that is brought about by treatment with pharmacological agents" [https://orcid.org/0000-0003-3691-0324]
synonym: "pharmacologically induced seizures" RELATED []
is_a: MP:0009357 ! abnormal seizure response to inducing agent
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0000951
name: sporadic seizures
alt_id: MP:0001498
def: "occasional seizures occurring at irregular intervals" [https://orcid.org/0000-0003-3691-0324]
synonym: "spontaneous seizures" EXACT []
is_a: MP:0002064 ! seizures

[Term]
id: MP:0000952
name: abnormal CNS glial cell morphology
def: "any structural anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MESH:A08.637]
synonym: "abnormal CNS glia" BROAD []
synonym: "abnormal CNS glia morphology" EXACT []
synonym: "CNS glia abnormalities" BROAD []
is_a: MP:0003634 ! abnormal glial cell morphology

[Term]
id: MP:0000953
name: abnormal oligodendrocyte morphology
def: "any structural anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
synonym: "abnormal oligodendrocytes" BROAD []
synonym: "abnormal oligodendroglia" BROAD []
synonym: "abnormal oligodendroglial cell morphology" EXACT []
synonym: "abnormal oligoglia" BROAD []
synonym: "abnormal oligoglial cell morphology" EXACT []
is_a: MP:0000952 ! abnormal CNS glial cell morphology

[Term]
id: MP:0000954
name: decreased oligodendrocyte progenitor number
def: "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
synonym: "decreased oligodendrocyte precursor number" EXACT []
synonym: "reduced oligodendrocyte progenitor number" EXACT []
synonym: "reduced oligodendrocyte progenitor numbers" EXACT []
is_a: MP:0014325 ! abnormal oligodendrocyte progenitor morphology

[Term]
id: MP:0000955
name: abnormal spinal cord morphology
def: "any structural anomaly of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [https://orcid.org/0000-0003-3691-0324]
synonym: "spinal cord abnormalities" BROAD []
synonym: "spinal cord dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0000956
name: decreased spinal cord size
def: "smaller appearance of the spinal cord" [PMID:8837770]
synonym: "reduced spinal cord size" EXACT []
synonym: "small spinal cord" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0000958
name: peripheral nervous system degeneration
def: "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "degeneration of peripheral nervous system" EXACT []
is_a: MP:0002229 ! neurodegeneration

[Term]
id: MP:0000959
name: abnormal somatic sensory system morphology
def: "any structural anomaly of the neural tissue involved in the transmission of sensory signals" [https://orcid.org/0000-0003-3691-0324]
synonym: "somatic sensory system abnormalities" BROAD []
synonym: "somatic sensory system dysplasia" NARROW []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0000960
name: abnormal sensory ganglion morphology
def: "any structural anomaly of the clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells" [https://orcid.org/0000-0003-3691-0324, MESH:A08.340.390]
synonym: "abnormal sensory ganglia" BROAD []
synonym: "sensory ganglia abnormalities" BROAD []
synonym: "sensory ganglion dysplasia" NARROW []
is_a: MP:0000959 ! abnormal somatic sensory system morphology

[Term]
id: MP:0000961
name: abnormal dorsal root ganglion morphology
alt_id: MP:0001104
def: "any structural anomaly of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [https://orcid.org/0000-0003-3691-0324, MESH:A08.340.390.340]
synonym: "abnormal dorsal root ganglia" BROAD []
synonym: "abnormal dorsal root ganglion dysplasia" NARROW []
synonym: "abnormal DRGs" BROAD []
synonym: "abnormal spinal ganglia" BROAD []
synonym: "abnormal spinal ganglion dysplasia" NARROW []
synonym: "abnormal spinal ganglion morphology" EXACT []
synonym: "dorsal root ganglia abnormalities" BROAD []
synonym: "spinal ganglia abnormalities" BROAD []
is_a: MP:0000960 ! abnormal sensory ganglion morphology

[Term]
id: MP:0000962
name: disorganized dorsal root ganglion
def: "loss of segmentation pattern of dorsal root ganglia or loss of regular spacing between the ganglia" [PMID:10804168, PMID:10804169]
synonym: "disorganised dorsal root ganglia" EXACT []
synonym: "disorganized DRG" EXACT []
synonym: "disorganized spinal ganglia" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0000963
name: fused dorsal root ganglion
def: "loss of DRG spacing pattern and the appearance of two or more ganglia as one" [PMID:10804168, PMID:10804169]
synonym: "dorsal root ganglia fusion" EXACT []
synonym: "fused dorsal root ganglia" EXACT []
synonym: "fused DRG" EXACT []
synonym: "fused spinal ganglia" EXACT []
synonym: "fusion of dorsal root ganglia" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0000964
name: small dorsal root ganglion
def: "reduced size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
synonym: "decreased dorsal root ganglion size" EXACT []
synonym: "reduced dorsal root ganglion size" EXACT []
synonym: "small DRG" EXACT []
synonym: "small spinal ganglion" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0000965
name: abnormal sensory neuron morphology
def: "any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal sensory neurons" BROAD []
is_a: MP:0000959 ! abnormal somatic sensory system morphology
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0000966
name: decreased sensory neuron number
def: "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "reduced sensory neuron number" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0008948 ! decreased neuron number

[Term]
id: MP:0000968
name: abnormal sensory neuron innervation pattern
alt_id: MP:0000967
def: "any changes in the placement, morphology or number of sensory nerve fibers to sensory termini or to spinal cord" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal sensory neuron projections" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0000969
name: abnormal nociceptor morphology
def: "any structural anomaly of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MESH:A08.800.550.700.650]
synonym: "abnormal nociceptors" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology

[Term]
id: MP:0000970
name: abnormal polymodal receptor morphology
def: "anomaly in a sensory receptor that may be stimulated by mechanical, thermal or chemical means" [ISBN:0838580343]
synonym: "abnormal polymodal receptors" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology

[Term]
id: MP:0000971
name: abnormal thermoreceptor morphology
def: "any structural anomaly of any of the cellular receptors that mediate the sense of temperature; in vertebrates, these are most often located under the skin" [MESH:A08.800.550.700.840]
synonym: "abnormal thermal receptors" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology

[Term]
id: MP:0000972
name: abnormal mechanoreceptor morphology
def: "anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [ISBN:0-683-40008-8]
synonym: "abnormal mechanoreceptors" BROAD []
is_a: MP:0000959 ! abnormal somatic sensory system morphology

[Term]
id: MP:0000973
name: abnormal cutaneous/subcutaneous mechanoreceptor morphology
def: "any structural anomaly of the neuronal receptors that respond to mechanical pressure or distortion in the skin" [ISBN:0-683-40008-8, PMID:21304548]
synonym: "abnormal cutaneous/subcutaneous mechanoreceptors" BROAD []
is_a: MP:0000972 ! abnormal mechanoreceptor morphology

[Term]
id: MP:0000974
name: abnormal hair guard neuron morphology
def: "anomaly of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals" [PMID:21304548]
synonym: "abnormal G hair neuron morphology" EXACT []
synonym: "abnormal hair guard neurons" BROAD []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000975
name: absent hair guard neurons
def: "absence of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals" [PMID:21304548]
synonym: "absent G hair neurons" EXACT []
is_a: MP:0000974 ! abnormal hair guard neuron morphology

[Term]
id: MP:0000976
name: hyperinnervation of hair guard cells
def: "more robust innervation of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals" [PMID:21304548]
synonym: "hyperinnervation of G hair neurons" EXACT []
is_a: MP:0000974 ! abnormal hair guard neuron morphology

[Term]
id: MP:0000977
name: abnormal hair-tylotrich neuron morphology
def: "anomaly of the subcutaneous mechanoreceptors that innervate tylotrich hair follicles" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hair-tylotrich neurons" BROAD []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000978
name: hyperinnervation of hair-tylotrich cells
def: "more robust innervation of the hair tylotrich cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000977 ! abnormal hair-tylotrich neuron morphology

[Term]
id: MP:0000979
name: abnormal hair-down neuron morphology
def: "anomaly of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli" [PMID:21304548, PMID:21892923]
synonym: "abnormal D-hair neuron morphology" EXACT []
synonym: "abnormal D-hair receptors" BROAD []
synonym: "abnormal hair-down neurons" BROAD []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000980
name: absent hair-down neurons
def: "absence of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli" [PMID:21304548, PMID:21892923]
synonym: "loss of hair-down neurons" BROAD []
is_a: MP:0000979 ! abnormal hair-down neuron morphology

[Term]
id: MP:0000981
name: hyperinnervation of hair-down cells
def: "more robust innervation of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli" [PMID:21892923]
is_a: MP:0000979 ! abnormal hair-down neuron morphology

[Term]
id: MP:0000982
name: abnormal Meissner's corpuscle morphology
def: "any structural anomaly of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects" [ISBN:0-683-40008-8, PMID:21304548]
synonym: "abnormal oval corpuscle morphology" EXACT []
synonym: "abnormal touch corpuscle morphology" EXACT []
synonym: "Meissner's corpuscle dysplasia" NARROW []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000983
name: enlarged Meissner's corpuscles
def: "larger than average size of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects" [PMID:21304548]
synonym: "enlarged oval corpuscle" EXACT []
synonym: "enlarged touch corpuscle" EXACT []
synonym: "increased Meissner's corpuscle size" EXACT []
is_a: MP:0000982 ! abnormal Meissner's corpuscle morphology

[Term]
id: MP:0000984
name: hyperinnervation of Meissner's corpuscle
def: "more robust supply of nerve fibers connected to any part of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects" [ISBN:0-683-40008-8, PMID:21304548]
is_a: MP:0000982 ! abnormal Meissner's corpuscle morphology

[Term]
id: MP:0000985
name: abnormal Merkel's receptor morphology
def: "any structural anomaly of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MESH:A08.800.550.700.500.425]
synonym: "abnormal Merkel cells" BROAD []
synonym: "abnormal Merkel receptors" BROAD []
synonym: "Merkel's receptor dysplasia" NARROW []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000986
name: increased Merkel's receptor number
def: "greater than the normal number of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MESH:A08.800.550.700.500.425]
synonym: "increased Merkel cell number" EXACT []
synonym: "increased Merkel receptor number" EXACT []
synonym: "increased numbers of Merkel's receptors" EXACT []
is_a: MP:0000985 ! abnormal Merkel's receptor morphology
is_a: MP:0006006 ! increased sensory neuron number

[Term]
id: MP:0000987
name: hyperinnervation of Merkel's receptor
def: "more robust supply of nerve fibers connected to the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MESH:A08.800.550.700.500.425, MGI:cwg]
synonym: "hyperinnervation of Merkel cells" EXACT []
synonym: "hyperinnervation of Merkel receptors" EXACT []
is_a: MP:0000985 ! abnormal Merkel's receptor morphology

[Term]
id: MP:0000988
name: abnormal pacinian corpuscle morphology
def: "any structural anomaly of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers; trasmit signals generated by vibrations when grasping an object" [MESH:A08.800.550.700.500.700, PMID:21304548]
synonym: "abnormal lamellar corpuscle morphology" EXACT []
synonym: "abnormal lamellated corpuscle morphology" EXACT []
synonym: "pacinian corpuscle dysplasia" NARROW []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000989
name: abnormal Ruffini's corpuscle morphology
def: "any structural anomaly in the sensory cells in the subcutaneous tissue of the digits specialized to transduce mechanical stimuli, skin stretch, direction of object motion, hand shape and finger position" [ISBN:0-683-40008-8, PMID:21304548]
synonym: "Ruffini's corpuscle dysplasia" NARROW []
is_a: MP:0000973 ! abnormal cutaneous/subcutaneous mechanoreceptor morphology

[Term]
id: MP:0000990
name: abnormal skeletal muscle mechanoreceptor morphology
def: "any structural anomaly of the receptors that respond to mechanical pressure or distortion in the skeletal muscle" [ISBN:0-683-40008-8]
synonym: "abnormal muscle/skeletal mechanoreceptors" BROAD []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0000972 ! abnormal mechanoreceptor morphology

[Term]
id: MP:0000991
name: abnormal primary muscle spindle morphology
def: "any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and sensitive to stretch velocity" [ISBN:0838580343]
synonym: "abnormal muscle spindle-primary morphology" EXACT []
is_a: MP:0004069 ! abnormal muscle spindle morphology

[Term]
id: MP:0000992
name: absent primary muscle spindle
def: "missing sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity" [ISBN:0838580343]
synonym: "absent muscle spindle -primary" EXACT []
is_a: MP:0000991 ! abnormal primary muscle spindle morphology

[Term]
id: MP:0000993
name: partial loss of primary muscle spindle
def: "missing a portion of the sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity" [ISBN:0838580343]
synonym: "partial loss of muscle spindle-primary" EXACT []
is_a: MP:0000991 ! abnormal primary muscle spindle morphology

[Term]
id: MP:0000994
name: abnormal secondary muscle spindle morphology
def: "any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and not sensitive to stretch velocity" [ISBN:0838580343]
synonym: "abnormal muscle spindle-secondary" EXACT []
is_a: MP:0004069 ! abnormal muscle spindle morphology

[Term]
id: MP:0000995
name: absent secondary muscle spindle
def: "lack of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity" [ISBN:0-471-31639-3]
synonym: "absent muscle spindle -secondary" EXACT []
is_a: MP:0000994 ! abnormal secondary muscle spindle morphology

[Term]
id: MP:0000996
name: partial loss of secondary muscle spindle
def: "missing a portion of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity" [ISBN:0-471-31639-3]
synonym: "partial loss of muscle spindle-secondary" EXACT []
is_a: MP:0000994 ! abnormal secondary muscle spindle morphology

[Term]
id: MP:0000997
name: abnormal synovial joint capsule morphology
def: "any structural anomaly of the sac or its contents that encloses the articulating ends of bones participating in a synovial joint" [ISBN:0-683-40008-8]
synonym: "abnormal articular capsule morphology" EXACT []
synonym: "abnormal capsula articularis morphology" EXACT []
synonym: "abnormal joint capsule morphology" EXACT []
synonym: "abnormal joint fibrous capsule morphology" EXACT []
synonym: "joint capsule dysplasia" NARROW []
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0000998
name: absent synovial joint capsule
def: "missing the sac that encloses the articulating ends of bones participating in a synovial joint" [ISBN:0-683-40008-8]
synonym: "absent articular capsule" EXACT []
synonym: "absent capsula articularis" EXACT []
synonym: "absent joint capsule" EXACT []
synonym: "absent joint fibrous capsule" EXACT []
is_a: MP:0000997 ! abnormal synovial joint capsule morphology

[Term]
id: MP:0000999
name: abnormal golgi tendon organ morphology
def: "any structural anomaly of the sensory organ in muscle that is involved in regulating muscle tension" [ISBN:0838580343]
synonym: "abnormal neurotendinous organ morphology" EXACT []
synonym: "abnormal neurotendinous spindle morphology" EXACT []
synonym: "golgi tendon organ dysplasia" NARROW []
is_a: MP:0000990 ! abnormal skeletal muscle mechanoreceptor morphology

[Term]
id: MP:0001000
name: absent golgi tendon organ
def: "missing sensory organ in muscle that is involved in regulating muscle tension" [ISBN:0838580343]
synonym: "absent neurotendinous organ" EXACT []
synonym: "absent neurotendinous spindle" EXACT []
is_a: MP:0000999 ! abnormal golgi tendon organ morphology

[Term]
id: MP:0001001
name: abnormal chemoreceptor morphology
def: "any structural anomaly of any of the cells specialized to detect chemical substances and relay that information centrally in the nervous system" [MESH:A08.800.550.700.120]
synonym: "abnormal chemoreceptors" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology

[Term]
id: MP:0001002
name: obsolete abnormal taste bud morphology
def: "OBSOLETE. any structural anomaly of the small sensory organs located in the tongue that contain gustatory receptor cells, basal cells, and supporting cells" [MESH:A03.556.500.885.779, MGI:cwg]
synonym: "abnormal taste buds" BROAD []
synonym: "taste bud dysplasia" EXACT []
is_obsolete: true

[Term]
id: MP:0001003
name: abnormal olfactory receptor morphology
def: "any structural anomaly of the proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the specialized neurons of the olfactory epithelium" [MESH:D12.776.543.750.100.600, MGI:cwg]
synonym: "abnormal odorant receptors" BROAD []
synonym: "abnormal odourant receptors" BROAD []
is_a: MP:0006092 ! abnormal olfactory sensory neuron morphology

[Term]
id: MP:0001004
name: abnormal retina photoreceptor morphology
def: "any structural anomaly of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A.08.663.650.650]
synonym: "abnormal photoreceptors" BROAD []
synonym: "abnormal retinal photoreceptor morphology" EXACT []
xref: CL:0000210
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0003728 ! abnormal retina photoreceptor layer morphology

[Term]
id: MP:0001005
name: abnormal retina rod cell morphology
def: "any structural anomaly of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane; rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision" [MESH:A08.663.650.650.670.650]
synonym: "abnormal retinal rod cell morphology" EXACT []
synonym: "abnormal rod morphology" BROAD []
synonym: "abnormal rods" BROAD []
xref: CL:0000604
is_a: MP:0001004 ! abnormal retina photoreceptor morphology

[Term]
id: MP:0001006
name: abnormal retina cone cell morphology
def: "any structural anomaly of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment; cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision" [MESH:A08.663.650.650.670.100]
synonym: "abnormal cone morphology" BROAD []
synonym: "abnormal cone photoreceptor morphology" EXACT []
synonym: "abnormal cones" BROAD []
synonym: "abnormal retinal cone cell morphology" EXACT []
xref: CL:0000573
is_a: MP:0001004 ! abnormal retina photoreceptor morphology

[Term]
id: MP:0001007
name: abnormal sympathetic system morphology
def: "any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [ISBN:0-683-40008-8, MESH:A08.800.050.800]
synonym: "abnormal adrenergic system morphology" EXACT []
synonym: "abnormal somatic sympathetic system morphology" EXACT []
synonym: "abnormal thoracolumbar system morphology" EXACT []
synonym: "sympathetic system abnormalities" BROAD []
synonym: "sympathetic system dysplasia" NARROW []
is_a: MP:0002751 ! abnormal autonomic nervous system morphology

[Term]
id: MP:0001008
name: abnormal sympathetic ganglion morphology
def: "any structural anomaly of the ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia" [MESH:A08.340.315.350]
synonym: "abnormal sympathetic ganglia morphology" EXACT []
synonym: "sympathetic ganglia abnormalities" BROAD []
synonym: "sympathetic ganglion dysplasia" NARROW []
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0001009
name: paravertebral ganglia hyperplasia
def: "increase in the number of normal cells in normal arrangement in the paravertebral ganglia, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic paravertebral ganglia" EXACT []
is_a: MP:0008317 ! abnormal paravertebral ganglion morphology

[Term]
id: MP:0001010
name: prevertebral ganglia hyperplasia
def: "increase in the number of normal cells in normal arrangement in the prevertebral ganglia, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic prevertebral ganglia" EXACT []
is_a: MP:0008316 ! abnormal prevertebral ganglion morphology

[Term]
id: MP:0001011
name: abnormal superior cervical ganglion morphology
def: "any structural anomaly of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [ISBN:0-683-40008-8]
synonym: "abnormal ganglion cervicale superius morphology" EXACT []
synonym: "abnormal superior cervical ganglia" BROAD []
synonym: "superior cervical ganglion dysplasia" NARROW []
is_a: MP:0008317 ! abnormal paravertebral ganglion morphology

[Term]
id: MP:0001012
name: superior cervical ganglion hypertrophy
def: "increase in the size of cells in the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [ISBN:0-683-40008-8]
synonym: "ganglion cervicale superius hypertrophy" EXACT []
synonym: "hypertrophic superior cervical ganglion" EXACT []
synonym: "hypertrophy of superior cervical ganglion" EXACT []
is_a: MP:0001013 ! enlarged superior cervical ganglion

[Term]
id: MP:0001013
name: enlarged superior cervical ganglion
def: "increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [ISBN:0-683-40008-8]
synonym: "enlarged ganglion cervicale superius" EXACT []
synonym: "increased superior cervical ganglion size" EXACT []
is_a: MP:0001011 ! abnormal superior cervical ganglion morphology

[Term]
id: MP:0001014
name: absent superior cervical ganglion
def: "lack of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [ISBN:0-683-40008-8]
synonym: "absence of superior cervical ganglion" EXACT []
synonym: "absent ganglion cervicale superius" EXACT []
is_a: MP:0001011 ! abnormal superior cervical ganglion morphology

[Term]
id: MP:0001015
name: small superior cervical ganglion
def: "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [ISBN:0-683-40008-8]
synonym: "decreased superior cervical ganglion size" EXACT []
synonym: "reduced superior cervical ganglion size" EXACT []
synonym: "small ganglion cervicale superius" EXACT []
is_a: MP:0001011 ! abnormal superior cervical ganglion morphology

[Term]
id: MP:0001016
name: abnormal middle cervical ganglion morphology
def: "any structural anomaly of the small ganglion located at the level of the cricoid cartilage of the laryngeal wall" [ISBN:0-683-40008-8]
synonym: "abnormal middle cervical ganglia morphology" BROAD []
synonym: "middle cervical ganglion dysplasia" NARROW []
is_a: MP:0008317 ! abnormal paravertebral ganglion morphology

[Term]
id: MP:0001017
name: abnormal stellate ganglion morphology
def: "any structural anomaly of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [ISBN:0-683-40008-8, MESH:A08.340.315.350.800]
synonym: "abnormal cervicothoracic ganglion morphology" EXACT []
synonym: "abnormal stellate ganglia morphology" EXACT []
synonym: "stellate ganglion dysplasisa" EXACT []
is_a: MP:0008317 ! abnormal paravertebral ganglion morphology

[Term]
id: MP:0001018
name: obsolete abnormal adrenal gland ganglion
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001019
name: abnormal L4 dorsal root ganglion morphology
alt_id: MP:0006406
def: "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fourth lumbar vertebra" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal L4 dorsal root ganglia" BROAD []
synonym: "abnormal L4 DRG morphology" EXACT []
synonym: "abnormal L4 ganglion morphology" EXACT []
synonym: "abnormal L4 sympathetic ganglia morphology" EXACT []
synonym: "abnormal L4 sympathetic ganglion morphology" EXACT []
synonym: "L4 dorsal root ganglion dysplasia" NARROW []
synonym: "L4 ganglion dysplasia" NARROW []
is_a: MP:0006404 ! abnormal lumbar dorsal root ganglion morphology

[Term]
id: MP:0001020
name: L4 dorsal root ganglion hypertrophy
def: "increased bulk size of the L4 spinal ganglion" [J:34172]
synonym: "hypertrophy of L4 ganglion" EXACT []
synonym: "L4 DRG ganglion hypertrophy" EXACT []
synonym: "L4 ganglia hypertrophy" EXACT []
is_a: MP:0001019 ! abnormal L4 dorsal root ganglion morphology

[Term]
id: MP:0001021
name: small L4 dorsal root ganglion
def: "reduced size of the L4 spinal ganglion" [J:17792]
synonym: "decreased L4 dorsal root ganglion size" EXACT []
synonym: "reducedL4 dorsal root ganglion size" EXACT []
synonym: "small L4 dorsal root ganglia" EXACT []
synonym: "small L4 DRG ganglion" EXACT []
is_a: MP:0001019 ! abnormal L4 dorsal root ganglion morphology

[Term]
id: MP:0001022
name: abnormal L5 dorsal root ganglion morphology
alt_id: MP:0006407
def: "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fifth lumbar vertebra" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal L5 dorsal root ganglia morphology" EXACT []
synonym: "abnormal L5 DRG morphology" EXACT []
synonym: "abnormal L5 ganglion morphology" EXACT []
synonym: "abnormal L5 sympathetic ganglia morphology" EXACT []
synonym: "abnormal L5 sympathetic ganglion morphology" EXACT []
synonym: "L5 dorsal root ganglion dysplasia" NARROW []
synonym: "L5 ganglion dysplasia" NARROW []
is_a: MP:0006404 ! abnormal lumbar dorsal root ganglion morphology

[Term]
id: MP:0001023
name: L5 dorsal root ganglion hypertrophy
def: "increased bulk size of L5 spinal ganglion" [J:34172]
synonym: "hypertrophy of L5 ganglion" EXACT []
synonym: "L5 dorsal root ganglia hypertrophy" EXACT []
synonym: "L5 DRG hypertrophy" EXACT []
is_a: MP:0001022 ! abnormal L5 dorsal root ganglion morphology

[Term]
id: MP:0001024
name: small L5 dorsal root ganglion
def: "reduced size of the L5 spinal ganglion" [J:17792]
synonym: "decreased L5 dorsal root ganglion size" EXACT []
synonym: "reduced L5 dorsal root ganglion size" EXACT []
synonym: "small L5 dorsal root ganglia" EXACT []
synonym: "small L5 DRG" EXACT []
is_a: MP:0001022 ! abnormal L5 dorsal root ganglion morphology

[Term]
id: MP:0001025
name: abnormal sympathetic neuron morphology
def: "any structural anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [MESH:A08.800.050.800]
synonym: "abnormal sympathetic neurons" BROAD []
synonym: "sympathetic neuron abnormalities" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0001026
name: abnormal adrenergic neuron morphology
def: "any structural anomaly of the neurons which secrete norepinephrine as a neurotransmitter; adrenergic neurons are mostly sympathetic postganglionic nerves plus some within specific brainstem foci" [ISBN:070202788X]
synonym: "abnormal adrenergic neurons" BROAD []
synonym: "adrenergic neuron abnormalities" BROAD []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0001027
name: obsolete abnormal adrenergic innervation
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "adrenergic innervation abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0001028
name: obsolete adrenergic hyperinnervation of muscle
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001031
name: obsolete cholinergic hyperinnervation of muscle
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001032
name: abnormal peptidergic neuron morphology
def: "any structural anomaly of the nerve fibers that release small peptides as their neurotransmitter" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal peptidergic neurons" BROAD []
synonym: "peptidergic neuron abnormalities" BROAD []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0001033
name: abnormal parasympathetic system morphology
def: "any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system" [ISBN:0-683-40008-8, MESH:A08.800.050.600]
synonym: "abnormal cholinergic system morphology" EXACT []
synonym: "abnormal craniosacral system morphology" EXACT []
synonym: "abnormal somatic parasympathetic system morphology" EXACT []
synonym: "parasympathetic system abnormalities" BROAD []
synonym: "parasympathetic system dysplasia" NARROW []
is_a: MP:0002751 ! abnormal autonomic nervous system morphology

[Term]
id: MP:0001034
name: abnormal parasympathetic ganglion morphology
def: "any structural anomaly of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MESH:A08.340.315.300]
synonym: "abnormal parasympathetic ganglia" BROAD []
synonym: "parasympathetic ganglion dysplasia" NARROW []
is_a: MP:0001033 ! abnormal parasympathetic system morphology

[Term]
id: MP:0001035
name: abnormal submandibular ganglion morphology
def: "any structural anomaly of the ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands" [ISBN:0-683-40008-8]
synonym: "abnormal submandibular ganglia" BROAD []
synonym: "abnormal submaxillary ganglion morphology" EXACT []
synonym: "submandibular ganglion dysplasia" NARROW []
xref: MA:0002470
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology

[Term]
id: MP:0001036
name: small submandibular ganglion
def: "reduced size of the small parasympathetic ganglion of the lingual nerve" [ISBN:0-683-40008-8, J:53284]
synonym: "small submandibular ganglia" EXACT []
synonym: "small submaxillary ganglion" EXACT []
is_a: MP:0001035 ! abnormal submandibular ganglion morphology

[Term]
id: MP:0001037
name: abnormal parasympathetic neuron morphology
def: "any structural anomaly of the neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands" [MESH:A08.800.050.600]
synonym: "abnormal parasympathetic neurons" BROAD []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0001033 ! abnormal parasympathetic system morphology

[Term]
id: MP:0001038
name: abnormal cholinergic neuron morphology
alt_id: MP:0001029
def: "any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter, including include alpha-motor neurons of the spinal cord, cranial nerves innervating skeletal muscle, preganglionic sympathetic and postganglionic parasympathetic neurons" [ISBN:070202788X, ISBN:0838580343]
synonym: "cholinergic neuron abnormalities" BROAD []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0001039
name: obsolete abnormal cholinergic innervation
alt_id: MP:0001030
def: "OBSOLETE. malformation or absence of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter" [ISBN:0838580343]
synonym: "cholinergic innervation abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0001040
name: deficient enteric cholinergic innervation
alt_id: MP:0001050
def: "defective or incomplete supply of nerve fibers to the intestinal system that utilize acetylcholine as a neurotransmitter" [J:53284]
is_a: MP:0001049 ! abnormal enteric cholinergic innervation

[Term]
id: MP:0001041
name: obsolete absent lacrimal gland cholinergic innervation
def: "OBSOLETE. missing supply of nerve fibers to the gland that secretes tears" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001042
name: obsolete absent sublingual salivary gland cholinergic innervation
def: "OBSOLETE. missing supply of nerve fibers to the exocrine gland on the floor of the mouth that secretes saliva" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001043
name: obsolete absent parotid salivary gland cholinergic innervation
def: "OBSOLETE. missing supply of nerve fibers to the exocrine gland lateral to the jaw that secretes saliva" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001044
name: abnormal enteric nervous system morphology
def: "any structural anomaly of the part of the autonomic nervous system that innervates the gastrointestinal tract, the pancreas, and the gallbladder and can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport" [https://orcid.org/0000-0003-3691-0324, MESH:A08.800.050.150]
synonym: "enteric nervous system abnormalities" BROAD []
synonym: "enteric nervous system dysplasia" NARROW []
is_a: MP:0002751 ! abnormal autonomic nervous system morphology

[Term]
id: MP:0001045
name: abnormal enteric ganglia morphology
def: "any structural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal enteric ganglia" BROAD []
synonym: "enteric ganglion dysplasia" NARROW []
is_a: MP:0001044 ! abnormal enteric nervous system morphology

[Term]
id: MP:0001046
name: abnormal enteric neuron morphology
def: "any structural anomaly of the neurons that innervate the esophagus, stomach, small and large bowel" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal enteric neurons" BROAD []
is_a: MP:0001044 ! abnormal enteric nervous system morphology
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0001047
name: abnormal enteric cholinergic neuron morphology
def: "any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter and innervate the esophagus, stomach, small and large bowel" [ISBN:0838580343]
synonym: "abnormal enteric cholinergic neurons" BROAD []
is_a: MP:0001038 ! abnormal cholinergic neuron morphology
is_a: MP:0001046 ! abnormal enteric neuron morphology

[Term]
id: MP:0001048
name: absent enteric neurons
def: "absence of the neurons that innervate the esophagus, stomach, small and large bowel" [ISBN:0838580343]
synonym: "absence of enteric neurons" EXACT []
is_a: MP:0001046 ! abnormal enteric neuron morphology

[Term]
id: MP:0001049
name: abnormal enteric cholinergic innervation
def: "any structural anomaly of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter to the intestinal system" [ISBN:0-683-40008-8]
is_a: MP:0001047 ! abnormal enteric cholinergic neuron morphology

[Term]
id: MP:0001051
name: abnormal somatic motor system morphology
def: "any structural anomaly of the neural tissue involved in the transmission of motor signals" [https://orcid.org/0000-0003-3691-0324]
synonym: "somatic motor system abnormalities" BROAD []
synonym: "somatic motor system dysplasia" NARROW []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0001052
name: abnormal innervation pattern to muscle
def: "any changes in the placement, morphology or number of sensory, sympathetic or motor nerves to targets in muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal muscle innervation" RELATED []
synonym: "muscle innervation abnormalities" EXACT []
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0001053
name: abnormal neuromuscular synapse morphology
def: "any structural anomaly of the membrane to membrane contact of a motor axon and a muscle myofiber that is responsible for the transmission of nerve impulses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal neuromuscular junction morphology" EXACT []
synonym: "abnormal NMJ morphology" EXACT []
synonym: "neuromuscular synapse abnormalities" BROAD []
is_a: MP:0001051 ! abnormal somatic motor system morphology
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0001054
name: failure of neuromuscular synapse presynaptic differentiation
def: "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission at the neuromuscular synapse" [PMID:10742104]
synonym: "failure of neuromuscular synapse pre-synaptic differentiation" EXACT []
is_a: MP:0001053 ! abnormal neuromuscular synapse morphology

[Term]
id: MP:0001055
name: failure of neuromuscular synapse postsynaptic differentiation
def: "inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation at the neuromuscular synapse" [PMID:10742104]
synonym: "failure of neuromuscular synapse post-synaptic differentiation" EXACT []
is_a: MP:0001053 ! abnormal neuromuscular synapse morphology

[Term]
id: MP:0001056
name: abnormal cranial nerve morphology
def: "any structural anomaly of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9362461]
synonym: "abnormal cranial nerves" BROAD []
synonym: "cranial nerve abnormalities" BROAD []
synonym: "cranial nerve dysplasia" NARROW []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0001059
name: optic nerve atrophy
alt_id: MP:0001331
def: "acquired diminution of the size of the optic nerve, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic optic nerve" EXACT []
synonym: "atrophy of optic nerve" EXACT []
is_a: MP:0020342 ! small optic nerve

[Term]
id: MP:0001061
name: abnormal oculomotor nerve morphology
def: "any structural anomaly of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [ISBN:0-683-40008-8]
synonym: "abnormal CN-III morphology" EXACT []
synonym: "oculomotor nerve abnormalities" BROAD []
synonym: "oculomotor nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001062
name: absent oculomotor nerve
def: "absence of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye" [ISBN:0-683-40008-8, PMID:7925010]
synonym: "absence of oculomotor nerve" EXACT []
synonym: "absent CN-III nerve" EXACT []
is_a: MP:0001061 ! abnormal oculomotor nerve morphology

[Term]
id: MP:0001063
name: abnormal trochlear nerve morphology
def: "any structural anomaly of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye" [MESH:A08.800.800.120.800, MGI:cwg]
synonym: "abnormal CN-IV morphology" EXACT []
synonym: "trochlear nerve abnormalities" BROAD []
synonym: "trochlear nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001064
name: absent trochlear nerve
def: "absence of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye" [ISBN:0-683-40008-8, PMID:7925010]
synonym: "absence of trochlear nerve" EXACT []
synonym: "absent CN-IV nerve" EXACT []
is_a: MP:0001063 ! abnormal trochlear nerve morphology

[Term]
id: MP:0001065
name: abnormal trigeminal nerve morphology
def: "any structural anomaly of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular" [ISBN:0-683-40008-8, ISBN:0838580343]
synonym: "abnormal CN-V morphology" EXACT []
synonym: "trigeminal nerve abnormalities" BROAD []
synonym: "trigeminal nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001066
name: absent trigeminal nerve
def: "lack of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular" [ISBN:0-683-40008-8]
synonym: "absence of trigeminal nerve" EXACT []
synonym: "absent CN-V nerve" EXACT []
is_a: MP:0001065 ! abnormal trigeminal nerve morphology

[Term]
id: MP:0001067
name: absent mandibular nerve
def: "missing third division of the trigeminal nerve" [ISBN:0-683-40008-8]
synonym: "absence of mandibular nerve" EXACT []
is_a: MP:0001066 ! absent trigeminal nerve
is_a: MP:0009800 ! abnormal mandibular nerve morphology

[Term]
id: MP:0001068
name: abnormal mandibular nerve branching
def: "malformed or misprojected axons of the mandibular nerve" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal branching of mandibular nerve" EXACT []
is_a: MP:0009800 ! abnormal mandibular nerve morphology

[Term]
id: MP:0001069
name: obsolete absent trigeminal nerve connections to hindbrain
def: "OBSOLETE. missing axonal connection from the trigeminal ganglion to the pons and medulla oblongata" [J:33038]
synonym: "absence of trigeminal nerve connections to hindbrain" EXACT []
is_obsolete: true

[Term]
id: MP:0001070
name: abnormal abducens nerve morphology
def: "any structural anomaly of the sixth cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [MESH:A08.800.800.120.030, MGI:cwg]
synonym: "abducens nerve abnormalities" BROAD []
synonym: "abducens nerve dysplasia" NARROW []
synonym: "abnormal CN-VI morphology" EXACT []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001071
name: abnormal facial nerve morphology
def: "any structural anomaly of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue; principal branches are the superficial opthalmic, buccal, palatine and hyomandibular" [ISBN:0-683-40008-8, ISBN:0838580343, PMID:7477377]
synonym: "abnormal CN-VII morphology" EXACT []
synonym: "facial nerve abnormalities" BROAD []
synonym: "facial nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001072
name: abnormal vestibulocochlear nerve morphology
def: "any structural anomaly in the composite sensory nerve innervating the receptor cells of the membranous labyrinth; it consists of two major, anatomically and functionally distinct components, each of which have different central connections: the vestibular nerve and the cochlear nerve" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:1680563]
synonym: "abnormal CN-VIII morphology" EXACT []
synonym: "abnormal eighth cranial nerve [CN VIII] morphology" EXACT []
synonym: "abnormal eighth nerve morphology" EXACT []
synonym: "abnormal nervus acusticus [CN VIII] morphology" EXACT []
synonym: "abnormal nervus octavus [CN VIII] morphology" EXACT []
synonym: "abnormal nervus statoacusticus [CN VIII] morphology" EXACT []
synonym: "abnormal nervus vestibulocochlearis [CN VIII] morphology" EXACT []
synonym: "abnormal octavus morphology" EXACT []
synonym: "abnormal statoacoustic nerve morphology" EXACT []
synonym: "vestibulocochlear nerve abnormalities" BROAD []
synonym: "vestibulocochlear nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001073
name: abnormal glossopharyngeal nerve morphology
def: "any structural anomaly of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion" [ISBN:0838580343]
synonym: "abnormal CN-IX morphology" EXACT []
synonym: "glossopharyngeal nerve abnormalities" BROAD []
synonym: "glossopharyngeal nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001074
name: abnormal vagus nerve morphology
def: "any structural anomaly of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis" [ISBN:0838580343]
synonym: "abnormal CN-X morphology" EXACT []
synonym: "abnormal vagal nerve morphology" EXACT []
synonym: "vagus nerve abnormalities" BROAD []
synonym: "vagus nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001075
name: abnormal accessory nerve morphology
def: "any structural anomaly of the eleventh cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord" [MESH:A08.800.800.120.060, MGI:cwg]
synonym: "abnormal CN-XI morphology" EXACT []
synonym: "abnormal spinal accessory nerve morphology" EXACT []
synonym: "accessory nerve dysplasia" NARROW []
synonym: "spinal accessory nerve abnormalities" BROAD []
synonym: "spinal accessory nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001076
name: abnormal hypoglossal nerve morphology
def: "any structural anomaly of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9362461]
synonym: "abnormal CN-XII morphology" EXACT []
synonym: "hypoglossal nerve abnormalities" BROAD []
synonym: "hypoglossal nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0001077
name: abnormal spinal nerve morphology
def: "any structural anomaly of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MESH:A08.800.800.720]
synonym: "abnormal spinal nerves" BROAD []
synonym: "spinal nerve abnormalities" BROAD []
synonym: "spinal nerve dysplasia" NARROW []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0001078
name: abnormal phrenic nerve morphology
def: "any structural anomaly of motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "phrenic nerve dysplasia" NARROW []
is_a: MP:0001077 ! abnormal spinal nerve morphology

[Term]
id: MP:0001079
name: absent phrenic nerve
def: "absence of the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absence of phrenic nerve" EXACT []
is_a: MP:0001078 ! abnormal phrenic nerve morphology

[Term]
id: MP:0001080
name: defasiculated phrenic nerve
def: "misprojection or failure to bundle the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0001078 ! abnormal phrenic nerve morphology
is_a: MP:0009450 ! abnormal axon fasciculation

[Term]
id: MP:0001081
name: abnormal cranial ganglia morphology
def: "any structural anomaly of the groups of nerve cell bodies associated with the twelve cranial nerves" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9362461]
synonym: "cranial ganglia abnormalities" BROAD []
synonym: "cranial ganglia dysplasia" NARROW []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0001082
name: abnormal geniculate ganglion morphology
def: "any structural anomaly of the group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [ISBN:0-683-40008-8]
synonym: "abnormal cranial ganglion VII morphology" EXACT []
synonym: "abnormal geniculate ganglia morphology" EXACT []
synonym: "abnormal geniculate ganglion of facial (VII) nerve morphology" EXACT []
synonym: "geniculate ganglia dysplasia" NARROW []
is_a: MP:0000960 ! abnormal sensory ganglion morphology
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0001083
name: small geniculate ganglion
def: "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [ISBN:0-683-40008-8]
synonym: "decreased geniculate ganglion size" EXACT []
synonym: "small cranial ganglion VII" EXACT []
synonym: "small geniculate ganglion of facial (VII) nerve" EXACT []
is_a: MP:0001082 ! abnormal geniculate ganglion morphology

[Term]
id: MP:0001084
name: abnormal petrosal ganglion morphology
alt_id: MP:0001099
def: "any structural anomaly of the larger, lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "abnormal extracraniale ganglion morphology" EXACT []
synonym: "abnormal inferior glossopharyngeal ganglion morphology" EXACT []
synonym: "abnormal inferior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve morphology" EXACT []
synonym: "abnormal petrosal ganglia morphology" EXACT []
synonym: "petrosal ganglion dysplasia" NARROW []
is_a: MP:0001096 ! abnormal glossopharyngeal ganglion morphology

[Term]
id: MP:0001085
name: small petrosal ganglion
def: "reduced size of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "reduced petrosal ganglion size" EXACT []
synonym: "small extracraniale ganglion" EXACT []
synonym: "small inferior glossopharyngeal ganglion" EXACT []
synonym: "small inferior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT []
synonym: "small petrosal ganglia" EXACT []
is_a: MP:0001084 ! abnormal petrosal ganglion morphology

[Term]
id: MP:0001086
name: absent petrosal ganglion
def: "absence of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "absent extracraniale ganglion" EXACT []
synonym: "absent inferior glossopharyngeal ganglion" EXACT []
synonym: "absent inferior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT []
synonym: "absent petrosal ganglia" EXACT []
is_a: MP:0001084 ! abnormal petrosal ganglion morphology

[Term]
id: MP:0001087
name: abnormal nodose ganglion morphology
alt_id: MP:0001103
def: "any structural anomaly of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "abnormal cranial ganglion X morphology" BROAD []
synonym: "abnormal inferior vagus ganglion morphology" EXACT []
synonym: "abnormal inferior vagus ganglion of the vagus (X) nerve morphology" EXACT []
synonym: "abnormal nodose ganglia morphology" EXACT []
synonym: "nodose ganglion dysplasia" NARROW []
is_a: MP:0000960 ! abnormal sensory ganglion morphology
is_a: MP:0001100 ! abnormal vagus ganglion morphology

[Term]
id: MP:0001088
name: small nodose ganglion
def: "reduced size of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "decreased nodose ganglion size" EXACT []
synonym: "reduced nodose ganglion size" EXACT []
synonym: "small cranial ganglion X" BROAD []
synonym: "small inferior vagus ganglion" EXACT []
synonym: "small inferior vagus ganglion of the vagus (X) nerve" EXACT []
synonym: "small nodose ganglia" EXACT []
is_a: MP:0001087 ! abnormal nodose ganglion morphology

[Term]
id: MP:0001089
name: absent nodose ganglion
def: "absence of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [ISBN:0-683-40008-8, PMID:9362461]
synonym: "absent cranial ganglion X" BROAD []
synonym: "absent inferior vagus ganglion" EXACT []
synonym: "absent inferior vagus ganglion of the vagus (X) nerve" EXACT []
synonym: "absent nodose ganglia" EXACT []
is_a: MP:0001087 ! abnormal nodose ganglion morphology

[Term]
id: MP:0001091
name: obsolete small vestibular cochlear ganglion
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0003703

[Term]
id: MP:0001092
name: abnormal trigeminal ganglion morphology
def: "any structural anomaly of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [ISBN:0-683-40008-8]
synonym: "abnormal cranial ganglion V morphology" EXACT []
synonym: "abnormal Gasserian ganglion morphology" EXACT []
synonym: "abnormal semi-lunar ganglion morphology" EXACT []
synonym: "abnormal semilunar ganglion morphology" EXACT []
synonym: "abnormal trigeminal ganglia morphology" EXACT []
synonym: "abnormal trigeminal ganglion of trigeminal (V) nerve morphology" EXACT []
synonym: "trigeminal ganglion dysplasia" NARROW []
is_a: MP:0000960 ! abnormal sensory ganglion morphology
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0001093
name: small trigeminal ganglion
def: "reduced size of the trigeminal ganglion" [J:17123, J:25565]
synonym: "decreased trigeminal ganglion size" EXACT []
synonym: "small cranial ganglion V" EXACT []
synonym: "small Gasserian ganglion" EXACT []
synonym: "small semi-lunar ganglion" EXACT []
synonym: "small semilunar ganglion" EXACT []
synonym: "small trigeminal ganglia" EXACT []
synonym: "small trigeminal ganglion of trigeminal (V) nerve" EXACT []
is_a: MP:0001092 ! abnormal trigeminal ganglion morphology

[Term]
id: MP:0001094
name: trigeminal ganglion hypertrophy
def: "increased bulk size due to increased cell size of the trigeminal ganglion" [J:34172]
synonym: "cranial ganglion V hypertrophy" EXACT []
synonym: "Gasserian ganglion hypertrophy" EXACT []
synonym: "hypertrophy of trigeminal ganglion" EXACT []
synonym: "semi-lunar ganglion hypertrophy" EXACT []
synonym: "semilunar ganglion hypertrophy" EXACT []
synonym: "trigeminal ganglia hypertrophy" EXACT []
synonym: "trigeminal ganglion of trigeminal (V) nerve hypertrophy" EXACT []
is_a: MP:0001095 ! enlarged trigeminal ganglion

[Term]
id: MP:0001095
name: enlarged trigeminal ganglion
def: "increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve" [J:17131]
synonym: "enlarged cranial ganglion V" EXACT []
synonym: "enlarged Gasserian ganglion" EXACT []
synonym: "enlarged semi-lunar ganglion" EXACT []
synonym: "enlarged semilunar ganglion" EXACT []
synonym: "enlarged trigeminal ganglia" EXACT []
synonym: "enlarged trigeminal ganglion of trigeminal (V) nerve" EXACT []
synonym: "increased trigeminal ganglion size" EXACT []
is_a: MP:0001092 ! abnormal trigeminal ganglion morphology

[Term]
id: MP:0001096
name: abnormal glossopharyngeal ganglion morphology
def: "any structural anomaly of the two groups of sensory neuron cell bodies associated with the ninth cranial nerve" [ISBN:0-683-40008-8]
synonym: "abnormal cranial ganglion IX morphology" EXACT []
synonym: "abnormal glossopharyngeal ganglia morphology" EXACT []
synonym: "glossopharyngeal ganglia dysplasia" NARROW []
synonym: "glossopharyngeal ganglion dysplasia" NARROW []
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0001097
name: abnormal superior glossopharyngeal ganglion morphology
def: "any structural anomaly of the upper, smaller ganglion of the glossopharyngeal nerve located at the jugular foramen" [ISBN:0-683-40008-8]
synonym: "abnormal intracranial ganglion morphology" EXACT []
synonym: "abnormal jugular ganglion morphology" BROAD []
synonym: "abnormal superior glossopharyngeal ganglia morphology" EXACT []
synonym: "abnormal superior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve morphology" EXACT []
synonym: "superior glossopharyngeal ganglia dysplasia" NARROW []
is_a: MP:0001096 ! abnormal glossopharyngeal ganglion morphology

[Term]
id: MP:0001098
name: small superior glossopharyngeal ganglion
def: "reduced size of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [ISBN:0-683-40008-8, J:18984]
synonym: "decreased superior glossopharyngeal ganglia size" EXACT []
synonym: "decreased superior glossopharyngeal ganglion size" EXACT []
synonym: "small intracranial ganglion" EXACT []
synonym: "small jugular ganglion" BROAD []
synonym: "small superior glossopharyngeal ganglia" EXACT []
synonym: "small superior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT []
is_a: MP:0001097 ! abnormal superior glossopharyngeal ganglion morphology

[Term]
id: MP:0001100
name: abnormal vagus ganglion morphology
def: "any structural anomaly of the group of sensory neuron cell bodies associated with the vagus nerve" [ISBN:0-683-40008-8]
synonym: "abnormal cranial ganglion X morphology" EXACT []
synonym: "abnormal vagus ganglia morphology" EXACT []
synonym: "vagus ganglia dysplasia" NARROW []
synonym: "vagus ganglion dysplasia" NARROW []
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0001101
name: abnormal superior vagus ganglion morphology
def: "any structural anomaly of the upper ganglion of the vagus nerve located at the jugular foramen" [ISBN:0-683-40008-8]
synonym: "abnormal jugular ganglion morphology" BROAD []
synonym: "abnormal superior vagus ganglia morphology" EXACT []
synonym: "abnormal superior vagus ganglion of the vagus (X) nerve morphology" EXACT []
synonym: "jugular ganglion dysplasia" NARROW []
synonym: "superior vagus ganglion dysplasia" NARROW []
is_a: MP:0001100 ! abnormal vagus ganglion morphology

[Term]
id: MP:0001102
name: small superior vagus ganglion
def: "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [ISBN:0-683-40008-8, J:18984]
synonym: "decreased superior vagus ganglion size" EXACT []
synonym: "small jugular ganglion" BROAD []
synonym: "small superior vagus ganglia" EXACT []
synonym: "small superior vagus ganglion of the vagus (X) nerve" EXACT []
is_a: MP:0001101 ! abnormal superior vagus ganglion morphology

[Term]
id: MP:0001105
name: abnormal PNS glial cell morphology
def: "any structural anomaly of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MESH:A08.637]
synonym: "abnormal neuroglia morphology" BROAD []
synonym: "abnormal PNS glia morphology" EXACT []
synonym: "PNS glia abnormalities" BROAD []
is_a: MP:0003634 ! abnormal glial cell morphology

[Term]
id: MP:0001106
name: abnormal Schwann cell morphology
def: "any structural anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
synonym: "abnormal Schwann cells" BROAD []
synonym: "Schwann cell abnormalities" BROAD []
is_a: MP:0001105 ! abnormal PNS glial cell morphology

[Term]
id: MP:0001107
name: decreased Schwann cell number
def: "fewer than normal number of cells that sheath the axons of the peripheral nervous system" [PMID:7477375]
synonym: "reduced Schwann cell number" EXACT []
is_a: MP:0001106 ! abnormal Schwann cell morphology

[Term]
id: MP:0001108
name: absent Schwann cells
def: "missing cells that sheath the axons of the peripheral nervous system" [J:43515]
synonym: "absence of Schwann cells" EXACT []
is_a: MP:0001107 ! decreased Schwann cell number

[Term]
id: MP:0001109
name: absent Schwann cell precursors
def: "missing progenitors of cells that sheath the axons of the peripheral nervous system" [J:43515]
synonym: "absence of Schwann cell precursors" EXACT []
is_a: MP:0004075 ! decreased Schwann cell precursor number

[Term]
id: MP:0001116
name: small gonad
def: "reduced size of the testis or the ovary" [ISBN:0-683-40008-8, J:34193]
synonym: "decreased gonad size" EXACT []
synonym: "reduced gonad size" EXACT []
is_a: MP:0002211 ! abnormal primary sex determination

[Term]
id: MP:0001117
name: absent gametes
def: "absence of mature reproductive cells, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex to give a zygote" [ISBN:0-683-40008-8]
synonym: "absence of gametes" EXACT []
is_a: MP:0001124 ! abnormal gametes

[Term]
id: MP:0001119
name: abnormal female reproductive system morphology
def: "any structural anomaly of the organs associated with producing offspring in the gender that bears the offspring" [ISBN:0-683-40008-8]
synonym: "abnormal female reproductive anatomy morphology" EXACT []
synonym: "female reproductive anatomy dysplasia" NARROW []
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0001120
name: abnormal uterus morphology
def: "any structural anomaly of the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal metra morphology" EXACT []
synonym: "abnormal uterine morphology" EXACT []
synonym: "uterine dysplasia" NARROW []
synonym: "uterus dysplasia" NARROW []
is_a: MP:0009209 ! abnormal internal female genitalia morphology

[Term]
id: MP:0001121
name: uterus hypoplasia
alt_id: MP:0003573
def: "decrease in the number of normal cells in normal arrangement in the uterus, typically resulting in decreased size" [J:45065]
synonym: "hypoplasia of the uterus" EXACT []
synonym: "hypoplastic uterus" EXACT []
synonym: "metra hypoplasia" EXACT []
synonym: "metral hypoplasia" EXACT []
synonym: "rudimentary metra" EXACT []
synonym: "rudimentary uterus" EXACT []
synonym: "uterine hypoplasia" EXACT []
is_a: MP:0002637 ! small uterus

[Term]
id: MP:0001123
name: dilated uterus
def: "stretched or widened luminal space of the female muscular organ of gestation" [J:50844]
synonym: "dilated metra" EXACT []
synonym: "dilated uteri" EXACT []
synonym: "metra dilation" EXACT []
synonym: "uterine dilation" EXACT []
synonym: "uterus dilation" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0001124
name: abnormal gametes
def: "anomaly of any mature reproductive cell, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex, to produce a zygote" [ISBN:0-683-40008-8]
is_a: MP:0002208 ! abnormal germ cell morphology

[Term]
id: MP:0001125
name: abnormal oocyte morphology
def: "any structural anomaly of the mature germ cells in the female" [ISBN:0-683-40008-8]
synonym: "abnormal oocytes" BROAD []
is_a: MP:0001931 ! abnormal oogenesis
is_a: MP:0006361 ! abnormal female germ cell morphology

[Term]
id: MP:0001126
name: abnormal ovary morphology
def: "any structural anomaly of the female reproductive gland containing the germ cells" [ISBN:0-683-40008-8]
synonym: "abnormal gonad morphology" BROAD []
synonym: "abnormal ovarian morphology" EXACT []
synonym: "abnormal ovaries" BROAD []
synonym: "ovarian dysplasia" NARROW []
synonym: "ovary dysplasia" NARROW []
is_a: MP:0009209 ! abnormal internal female genitalia morphology
is_a: MP:0013324 ! abnormal female reproductive gland morphology

[Term]
id: MP:0001127
name: small ovary
def: "reduced size of the female reproductive gland containing the germ cells" [ISBN:0-683-40008-8]
synonym: "decreased ovary size" EXACT []
synonym: "reduced ovary size" EXACT []
synonym: "small ovaries" EXACT []
is_a: MP:0001116 ! small gonad
is_a: MP:0004853 ! abnormal ovary size

[Term]
id: MP:0001128
name: ovary hyperplasia
def: "increase in the number of normal cells in normal arrangement in the ovary, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic ovaries" EXACT []
synonym: "hyperplastic ovary" EXACT []
synonym: "ovarian hyperplasia" EXACT []
is_a: MP:0004832 ! enlarged ovary

[Term]
id: MP:0001129
name: impaired ovarian folliculogenesis
alt_id: MP:0001122
def: "a block in the formation of the spherical ovum in the ovary" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "impaired folliculogenesis" BROAD []
synonym: "impaired ovary folliculogenesis" EXACT []
is_a: MP:0001130 ! abnormal ovarian folliculogenesis

[Term]
id: MP:0001130
name: abnormal ovarian folliculogenesis
def: "atypical formation or failure to form the spherical ovum in the ovary" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal folliculogenesis" BROAD []
synonym: "abnormal ovary folliculogenesis" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0001131
name: abnormal ovarian follicle morphology
def: "any structural anomaly of the sac-like structure in the ovary which surrounds an ovum" [ISBN:0-683-40008-8]
synonym: "abnormal growing ovarian follicle morphology" NARROW []
synonym: "abnormal ovarian follicles" BROAD []
synonym: "ovarian follicle dysplasia" NARROW []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0001132
name: absent mature ovarian follicles
def: "absence of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of mature ovarian follicles" EXACT []
is_a: MP:0001130 ! abnormal ovarian folliculogenesis
is_a: MP:0002682 ! decreased mature ovarian follicle number

[Term]
id: MP:0001133
name: impaired luteal cell differentiation
def: "abnormal development of the cells of the corpus luteum of the ovary" [ISBN:0-683-40008-8, PMID:8646780]
is_a: MP:0003507 ! abnormal ovary physiology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0001134
name: absent corpus luteum
def: "absence of the yellow endocrine body formed in the ovary after follicle rupture" [ISBN:0-683-40008-8]
synonym: "absent corpora lutea" EXACT []
is_a: MP:0002679 ! abnormal corpus luteum morphology

[Term]
id: MP:0001135
name: abnormal uterine cervix morphology
def: "any structural anomaly of the lower opening of the uterus to the vagina" [MGI:tc]
synonym: "abnormal canalis cervicis uteri morphology" EXACT []
synonym: "abnormal caudal segment of uterus morphology" EXACT []
synonym: "abnormal cervical canal morphology" EXACT []
synonym: "abnormal cervical canal of uterus morphology" EXACT []
synonym: "abnormal cervix morphology" BROAD []
synonym: "abnormal cervix uteri morphology" EXACT []
synonym: "abnormal neck of uterus morphology" EXACT []
synonym: "cervix dysplasia" BROAD []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0001136
name: dilated uterine cervix
def: "stretched or widened aperture of the lower opening of the uterus to the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "cervical canal dilation" EXACT []
synonym: "cervix dilation" BROAD []
synonym: "dilated canalis cervicis uteri" EXACT []
synonym: "dilated caudal segment of uterus" EXACT []
synonym: "dilated cervical canal" EXACT []
synonym: "dilated cervical canal of uterus" EXACT []
synonym: "dilated cervix" BROAD []
synonym: "dilated cervix uteri" EXACT []
synonym: "dilated neck of uterus" EXACT []
synonym: "uterine cervix dilation" EXACT []
is_a: MP:0001135 ! abnormal uterine cervix morphology

[Term]
id: MP:0001137
name: abnormal uterine cervix epithelium morphology
def: "any structural anomaly of the epithelial layer of the cervix" [MGI:tc]
synonym: "abnormal cervical epithelium morphology" BROAD []
synonym: "abnormal cervix epithelium morphology" BROAD []
synonym: "cervical epithelium dysplasia" BROAD []
synonym: "cervix epithelium dysplasia" BROAD []
is_a: MP:0001135 ! abnormal uterine cervix morphology

[Term]
id: MP:0001138
name: abnormal uterine cervix squamous epithelium morphology
def: "any structural anomaly of the scaly epithelial layer of the cervix" [MGI:tc]
synonym: "abnormal cervical squamous epithelium morphology" BROAD []
synonym: "abnormal cervix squamous epithelium morphology" BROAD []
synonym: "cervical squamous epithelium dysplasia" BROAD []
synonym: "cervix squamous epithelium dysplasia" BROAD []
is_a: MP:0001137 ! abnormal uterine cervix epithelium morphology

[Term]
id: MP:0001139
name: abnormal vagina morphology
def: "any structural anomaly of the part of the genital canal in the female that extends between the cervix of the uterus and the vestibule; it is an organ of copulation that receives the penis during sexual intercourse" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal vaginal morphology" EXACT []
synonym: "vaginal dysplasia" NARROW []
is_a: MP:0009209 ! abnormal internal female genitalia morphology

[Term]
id: MP:0001140
name: abnormal vagina epithelium morphology
def: "any structural anomaly of the epithelial layer of the vagina" [MGI:tc, PMID:10227294]
synonym: "abnormal vaginal epithelium morphology" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0001141
name: thickened vaginal epithelium
def: "increased depth of the vaginal epithelial layer" [PMID:1709129]
is_a: MP:0001140 ! abnormal vagina epithelium morphology

[Term]
id: MP:0001142
name: abnormal vagina orifice morphology
def: "any structural anomaly of the median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal introitus of vagina morphology" EXACT []
synonym: "abnormal orificium vaginae morphology" EXACT []
synonym: "abnormal ostium vaginae morphology" EXACT []
synonym: "abnormal vagina opening" EXACT []
synonym: "abnormal vaginal introitus morphology" EXACT []
synonym: "abnormal vaginal opening" EXACT []
synonym: "abnormal vaginal orifice morphology" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0001143
name: constricted vagina orifice
def: "shrunken, narrowed external median slit located inferior and posterior to the external urethral orifice in the female" [https://orcid.org/0000-0002-6490-7723]
synonym: "constricted vagina opening" EXACT []
synonym: "constricted vaginal introitus" EXACT []
synonym: "constricted vaginal opening" EXACT []
is_a: MP:0001142 ! abnormal vagina orifice morphology

[Term]
id: MP:0001144
name: vagina atresia
def: "imperforation or occlusion of the vagina, or adhesion of the walls of the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "closed vagina" RELATED []
synonym: "colpatresia" EXACT []
synonym: "complete failure of vagina opening" EXACT []
synonym: "fused vagina opening" EXACT []
synonym: "fused vaginal opening" RELATED []
synonym: "imperforate vagina" EXACT []
synonym: "vaginal atresia" EXACT []
is_a: MP:0001142 ! abnormal vagina orifice morphology

[Term]
id: MP:0001145
name: abnormal male reproductive system morphology
def: "any structural anomaly of the organs associated with producing offspring in the gender that produces spermatozoa" [ISBN:0-683-40008-8]
synonym: "abnormal male reproductive anatomy" BROAD []
synonym: "abnormality of male external genitalia" BROAD []
synonym: "male reproductive anatomy dysplasia" NARROW []
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0001146
name: abnormal testis morphology
alt_id: MP:0003206
def: "any structural anomaly of the male reproductive glands" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal didymus morphology" EXACT []
synonym: "abnormal gonad morphology" BROAD []
synonym: "abnormal male gonad morphology" EXACT []
synonym: "abnormal orchis morphology" EXACT []
synonym: "abnormal testes morphology" EXACT []
synonym: "abnormal testicle morphology" EXACT []
synonym: "abnormal testiculus morphology" EXACT []
synonym: "abnormality of the testis" BROAD []
synonym: "testicular dysplasia" NARROW []
synonym: "testis dysplasia" NARROW []
is_a: MP:0009205 ! abnormal internal male genitalia morphology
is_a: MP:0013325 ! abnormal male reproductive gland morphology

[Term]
id: MP:0001147
name: small testis
def: "reduced size of the male reproductive glands" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased testis size" EXACT []
synonym: "male hypogonadism" RELATED []
synonym: "microorchidism" EXACT []
synonym: "microrchidia" EXACT []
synonym: "reduced testis size" EXACT []
synonym: "small male gonad" EXACT []
synonym: "small testes" EXACT []
synonym: "small testicles" EXACT []
is_a: MP:0001116 ! small gonad
is_a: MP:0004849 ! abnormal testis size

[Term]
id: MP:0001148
name: enlarged testis
def: "increased size of the male reproductive glands" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged didymus" EXACT []
synonym: "enlarged male gonad" EXACT []
synonym: "enlarged testes" EXACT []
synonym: "enlarged testicles" EXACT []
synonym: "increased testis size" EXACT []
synonym: "macroorchidism" EXACT []
is_a: MP:0004849 ! abnormal testis size

[Term]
id: MP:0001149
name: testicular hyperplasia
def: "increase in the number of normal cells in normal arrangement in the testes, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic male gonad" EXACT []
synonym: "hyperplastic testes" EXACT []
synonym: "hyperplastic testicles" EXACT []
synonym: "testis hyperplasia" EXACT []
is_a: MP:0001148 ! enlarged testis

[Term]
id: MP:0001150
name: enlarged scrotum
def: "increased size of the external sac of skin that encloses the testes" [ISBN:0-683-40008-8, PMID:1709129]
synonym: "increased scrotum size" EXACT []
is_a: MP:0002669 ! abnormal scrotum morphology

[Term]
id: MP:0001151
name: enlarged foreskin
def: "increased size of the loose fold of skin that covers the penis" [PMID:1709129]
synonym: "increased foreskin size" EXACT []
is_a: MP:0003553 ! abnormal foreskin morphology

[Term]
id: MP:0001152
name: increased Leydig cell number
def: "increased number of the interstitial cells found adjacent to the seminiferous tubules in the testicle that produce testosterone in the presence of luteinizing hormone" [https://orcid.org/0000-0002-0371-1954]
synonym: "Leydig cell hyperplasia" NARROW []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0001153
name: small seminiferous tubules
def: "reduced diameter of the tubules in the testes where spermatogenesis occurs" [https://orcid.org/0000-0003-4606-0597]
synonym: "narrow seminiferous tubules" EXACT []
is_a: MP:0006307 ! abnormal seminiferous tubule size

[Term]
id: MP:0001154
name: seminiferous tubule degeneration
def: "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [https://orcid.org/0000-0003-3691-0324]
synonym: "degeneration of seminiferous tubules" EXACT []
is_a: MP:0002216 ! abnormal seminiferous tubule morphology

[Term]
id: MP:0001155
name: arrest of spermatogenesis
def: "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
is_a: MP:0001156 ! abnormal spermatogenesis

[Term]
id: MP:0001156
name: abnormal spermatogenesis
def: "incomplete maturation or aberrant formation of the male gametes" [J:58959]
synonym: "abnormal sperm development" EXACT []
is_a: MP:0001929 ! abnormal gametogenesis

[Term]
id: MP:0001157
name: small seminal vesicle
alt_id: MP:0000657
def: "reduced size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "decreased seminal vesicle size" EXACT []
synonym: "small seminal gland" RELATED []
synonym: "small seminal vesicles" EXACT []
is_a: MP:0004907 ! abnormal seminal vesicle size

[Term]
id: MP:0001158
name: abnormal prostate gland morphology
alt_id: MP:0000658
def: "any structural anomaly of the gland in males that secretes part of the seminiferous fluid" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "abnormal prostate morphology" EXACT []
synonym: "prostate dysplasia" NARROW []
synonym: "prostate gland dysplasia" NARROW []
xref: MA:0000404
is_a: MP:0009205 ! abnormal internal male genitalia morphology
is_a: MP:0013330 ! abnormal male accessory sex gland morphology

[Term]
id: MP:0001159
name: absent prostate gland
def: "missing gland in males that secretes part of the seminiferous fluid" [ISBN:0-683-40008-8]
synonym: "absence of prostate gland" EXACT []
synonym: "absent prostate" EXACT []
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0001163
name: abnormal prostate gland anterior lobe morphology
alt_id: MP:0000663
def: "any structural anomaly of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [PMID:12645922, PMID:3308446]
comment: In rodents, the prostate gland consists of three lobes, the anterior prostate (AP; also known as the coagulating gland), the dorsolateral prostate (DLP), and the ventral prostate (VP). These lobes are arranged circumferentially around the urethra and display characteristic patterns of ductal branching and protein secretion (PMID:3308446). In contrast, the adult human prostate lacks discernible lobular organization and, instead, completely envelops the urethra at the base of the bladder (PMID:3308446).
synonym: "abnormal anterior prostate morphology" EXACT []
synonym: "abnormal AP morphology" EXACT []
synonym: "abnormal CG morphology" EXACT []
synonym: "abnormal coagulating gland morphology" EXACT []
xref: MA:0002422
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0001167
name: prostate gland epithelial hyperplasia
alt_id: MP:0000667
def: "epithelium is multi-layered instead of columnar and has increased cell number" [PMID:10906459]
synonym: "hyperplastic prostate gland epithelium" EXACT []
synonym: "prostate epithelial hyperplasia" EXACT []
is_a: MP:0001168 ! abnormal prostate gland epithelium morphology

[Term]
id: MP:0001168
name: abnormal prostate gland epithelium morphology
alt_id: MP:0000668
def: "any structural anomaly of the prostate epithelium" [PMID:10906459]
synonym: "abnormal prostate epithelium morphology" EXACT []
synonym: "prostate epithelial dysplasia" NARROW []
xref: MA:0001737
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0001169
name: abnormal bulbourethral gland morphology
alt_id: MP:0000669
def: "any structural anomaly of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bulbo-urethral gland morphology" EXACT []
synonym: "abnormal Cowper's gland morphology" EXACT []
synonym: "abnormal glandula bulbourethralis morphology" EXACT []
synonym: "abnormal Mery gland morphology" EXACT []
synonym: "bulbourethral gland dysplasia" NARROW []
is_a: MP:0009205 ! abnormal internal male genitalia morphology
is_a: MP:0013330 ! abnormal male accessory sex gland morphology

[Term]
id: MP:0001170
name: bulbourethral gland hyperplasia
alt_id: MP:0000670
def: "increase in the number of normal cells in normal arrangement in the bulbourethral gland, typically resulting in increased size" [ISBN:0-683-40008-8, PMID:10906459]
synonym: "bulbo-urethral gland hyperplasia" EXACT []
synonym: "Cowper's gland hyperplasia" EXACT []
synonym: "hyperplastic bulbourethral gland" EXACT []
synonym: "hyperplastic Cowper's gland" EXACT []
synonym: "Mery gland hyperplasia" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology

[Term]
id: MP:0001173
name: obsolete decreased number of ductal cells of the bulbourethral gland
alt_id: MP:0000673
def: "OBSOLETE. fewer than the normal number of cells found in the ducts through which the bulbourethral glands discharge mucus into the spongy part of the urethra" [ISBN:0-683-40008-8]
synonym: "reduced number of ductal cells in the Cowper's gland" EXACT []
synonym: "reduced number of ductal cells of the bulbourethral gland" EXACT []
is_obsolete: true
consider: MP:0001169

[Term]
id: MP:0001175
name: abnormal lung morphology
def: "any structural anomaly of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal lung" BROAD []
synonym: "lung dysplasia" NARROW []
is_a: MP:0002132 ! abnormal respiratory system morphology

[Term]
id: MP:0001176
name: abnormal lung development
def: "anomaly in the process of formation of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0003115 ! abnormal respiratory system development

[Term]
id: MP:0001177
name: atelectasis
def: "decrease or absent air in the entire or part of a lung, with resulting loss of lung volume, due to trauma, blockage or congenital defect" [ISBN:0-683-40008-8]
synonym: "collapsed lung" BROAD []
synonym: "pulmonary collapse" BROAD []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology

[Term]
id: MP:0001178
name: pulmonary hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lung, typically resulting in decreased size" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "hypoplastic lung" EXACT []
synonym: "lung hypoplasia" EXACT []
is_a: MP:0003641 ! small lung

[Term]
id: MP:0001179
name: thick pulmonary interalveolar septum
def: "increased width of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick alveolar septa" EXACT []
synonym: "thick alveolar septum" EXACT []
synonym: "thick interalveolar septum" EXACT []
synonym: "thick septum interalveolare" EXACT []
is_a: MP:0010900 ! abnormal pulmonary interalveolar septum morphology

[Term]
id: MP:0001180
name: obsolete cellular infiltration of airway walls
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001181
name: absent lungs
def: "absence of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "absence of lungs" EXACT []
xref: Fyler:4206
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0001182
name: lung hemorrhage
def: "bleeding within the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs" [ISBN:0-683-40008-8]
synonym: "lung haemorrhage" EXACT []
synonym: "pulmonary bleeding" EXACT []
synonym: "pulmonary haemorrhage" EXACT []
synonym: "pulmonary hemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0002295 ! abnormal pulmonary circulation

[Term]
id: MP:0001183
name: overexpanded pulmonary alveolus
def: "expanded volume of one or more of the saclike terminal dilations of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries" [ISBN:0-683-40008-8]
synonym: "alveoli dilation" RELATED []
synonym: "alveolus dilation" RELATED []
synonym: "dilated alveoli" RELATED []
synonym: "dilated alveolus" RELATED []
synonym: "enlarged alveoli" RELATED []
synonym: "enlarged alveolus" RELATED []
synonym: "overexpanded pulmonary alveoli" EXACT []
synonym: "overexpanded respiratory alveoli" EXACT []
synonym: "overexpanded respiratory alveolus" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology

[Term]
id: MP:0001184
name: absent pulmonary alveoli
def: "absence of the saclike terminal dilation of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries" [ISBN:0-683-40008-8]
synonym: "absent respiratory alveoli" RELATED []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology

[Term]
id: MP:0001186
name: pigmentation phenotype
def: "the observable morphological and physiological characteristics of mammalian organisms that are manifested through the deposition or aggregation of coloring matter in any tissue or cell of the organism" [KSU:jbengtson]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0001188
name: hyperpigmentation
def: "excess of pigment in any or all tissues or a part of a tissue" [ISBN:0-683-40008-8, PMID:9778510]
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0001189
name: absent skin pigmentation
def: "lack of pigmentation of the skin" [PMID:9949198]
synonym: "albino" EXACT []
synonym: "pale skin" RELATED []
is_a: MP:0002095 ! abnormal skin pigmentation

[Term]
id: MP:0001190
name: reddish skin
def: "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [PMID:10921880]
subset: Europhenome_Terms
subset: IMPC
synonym: "erythema" EXACT []
synonym: "erythematous skin" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001191
name: abnormal skin condition
def: "any anomaly in the state or quality of the skin" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0001192
name: scaly skin
def: "loss of the outer layer of the epidermis in thick, dry scale-like patches" [PMID:8941642]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "skin scales" EXACT []
synonym: "skin scaling" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001193
name: psoriasis
def: "chronic skin lesions characterized by inflammation and silvery-scaly patches" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0001191 ! abnormal skin condition

[Term]
id: MP:0001194
name: dermatitis
alt_id: MP:0001205
alt_id: MP:0001206
def: "inflammation of the skin (redness and itching) caused by an allergic reaction or contact with an irritant" [PMID:8941642]
synonym: "inflamed skin" BROAD []
synonym: "irritated skin" EXACT []
is_a: MP:0004947 ! skin inflammation

[Term]
id: MP:0001195
name: flaky skin
def: "shedding flakes on the skin" [J:56641]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001196
name: shiny skin
def: "skin with a glossy or glistening appearance" [J:56641]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001197
name: oily skin
def: "skin secreting an unusually high amount of oil, resulting in a glossy, shiny appearance" [https://orcid.org/0000-0003-3691-0324]
synonym: "greasy skin" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001196 ! shiny skin

[Term]
id: MP:0001198
name: tight skin
def: "skin has a taut, stretched appearance" [PMID:10921880]
synonym: "constricted skin" EXACT []
synonym: "taut skin" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001199
name: thin skin
def: "reduced thickness of the outer protective layer of the body" [ISBN:0-683-40008-8]
is_a: MP:0001191 ! abnormal skin condition

[Term]
id: MP:0001200
name: thick skin
def: "greater thickness of the outer protective layer of the body" [ISBN:0-683-40008-8]
is_a: MP:0001191 ! abnormal skin condition

[Term]
id: MP:0001201
name: translucent skin
def: "skin that is more transparent to light than normal" [J:15108]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001202
name: skin photosensitivity
def: "abnormally heightened reactivity of the skin to sunlight" [ISBN:0-683-40008-8]
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0001203
name: increased sensitivity to skin irradiation
def: "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [PMID:9185996]
synonym: "decreased resistance to skin irradiation" EXACT []
synonym: "increased susceptibility to skin irradiation" RELATED []
synonym: "skin irradiation sensitivity" EXACT []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0001204
name: decreased sensitivity to skin irradiation
def: "decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [PMID:9185996]
synonym: "increased resistance to skin irradiation" EXACT []
synonym: "skin irradiation resistance" EXACT []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0001208
name: blistering
def: "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
synonym: "blister" EXACT []
synonym: "skin blister" EXACT []
synonym: "skin vesicle" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001209
name: spontaneous skin ulceration
def: "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
synonym: "skin ulceration" EXACT []
is_a: MP:0001212 ! skin lesions

[Term]
id: MP:0001210
name: skin ridges
def: "long raised strips of skin, usually aligned to the proximal-distal axis" [J:51296]
synonym: "thick skin ridges" NARROW []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001211
name: wrinkled skin
def: "irregular folds and/or indentations on the skin" [PMID:7925010]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001212
name: skin lesions
def: "focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "cutaneous lesions" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0001213
name: abnormal skin cell number
def: "greater than or fewer than the expected numbers of cells in the cutis" [MGI:cwg]
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0001214
name: skin hyperplasia
def: "increase in the number of normal cells in normal arrangement in the skin, typically resulting in increased thickness" [J:47225]
synonym: "hyperplastic skin" EXACT []
is_a: MP:0001213 ! abnormal skin cell number

[Term]
id: MP:0001215
name: skin hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the skin, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic skin" EXACT []
is_a: MP:0001213 ! abnormal skin cell number

[Term]
id: MP:0001216
name: abnormal epidermal layer morphology
alt_id: MP:0001225
def: "any structural anomaly of the superficial epithelial portion of the skin" [ISBN:0-683-40008-8]
synonym: "abnormal epidermis morphology" EXACT []
synonym: "epidermal dysplasia" NARROW []
synonym: "epidermal layer dysplasia" NARROW []
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0001217
name: absent epidermis
def: "missing the epidermal cell layer in the skin" [MGI:tc, PMID:10227294]
synonym: "absence of epidermal layer" EXACT []
synonym: "absence of epidermis" EXACT []
synonym: "loss of epidermal layer" BROAD []
synonym: "loss of epidermis" BROAD []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001218
name: thin epidermis
def: "reduced thickness of the superficial epithelial portion of the skin" [ISBN:0-683-40008-8, J:61790]
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001219
name: thick epidermis
def: "increase in the width of the epidermal cell layer in the skin" [PMID:8941642]
synonym: "thickened epidermis" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001220
name: epidermal necrosis
def: "morphological changes resulting from pathological death of the epidermal layer of skin; usually due to irreversible damage" [PMID:8941642]
synonym: "epidermis necrosis" EXACT []
synonym: "necrotic skin epidermis" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001221
name: epidermal atrophy
def: "acquired diminution of the size of epidermal layer of the skin, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001216 ! abnormal epidermal layer morphology
is_a: MP:0030584 ! skin atrophy

[Term]
id: MP:0001222
name: epidermal hyperplasia
def: "increase in the number of normal cells in normal arrangement in the epidermis, typically resulting in increased thickness" [ISBN:0-683-40008-8, PMID:8941642]
synonym: "hyperplastic epidermal layer" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001224
name: abnormal keratinocyte apoptosis
def: "aberrant programmed cell death or anomaly in the number of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
xref: GO:0006915
xref: GO:0030216
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0003453 ! abnormal keratinocyte physiology

[Term]
id: MP:0001230
name: epidermal desquamation
def: "shedding of the cuticle of the epidermis in scales or shreds" [ISBN:0-683-40008-8, PMID:10469309]
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001231
name: abnormal epidermis stratum basale morphology
def: "any structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8]
synonym: "abnormal basal cell layer morphology" EXACT []
synonym: "abnormal basal layer morphology" EXACT []
synonym: "abnormal columnar layer morphology" EXACT []
synonym: "abnormal germinative layer morphology" EXACT []
synonym: "abnormal palisade layer morphology" EXACT []
synonym: "abnormal stratum basale epidermis morphology" EXACT []
synonym: "abnormal stratum cylindricum morphology" EXACT []
synonym: "abnormal stratum germinativum morphology" EXACT []
synonym: "epidermis basal cell layer dysplasia" NARROW []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001232
name: absent epidermis stratum basale
def: "absence of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8]
synonym: "absence of basal layer" EXACT []
synonym: "absent basal cell layer" EXACT []
synonym: "absent basal layer" EXACT []
synonym: "absent columnar layer" EXACT []
synonym: "absent germinative layer" EXACT []
synonym: "absent palisade layer" EXACT []
synonym: "absent stratum basale epidermis" EXACT []
synonym: "absent stratum cylindricum" EXACT []
synonym: "absent stratum germinativum" EXACT []
is_a: MP:0001231 ! abnormal epidermis stratum basale morphology

[Term]
id: MP:0001233
name: abnormal epidermis suprabasal layer morphology
def: "any structural anomaly of the suprabasal layer of the epidermis" [PMID:10469309]
synonym: "abnormal suprabasal layer morphology" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001234
name: absent suprabasal layer
def: "absence of the suprabasal layer of the skin" [MGI:cwg]
synonym: "absence of suprabasal layer" EXACT []
is_a: MP:0001233 ! abnormal epidermis suprabasal layer morphology

[Term]
id: MP:0001235
name: disorganized suprabasal layer
def: "derangement of the pattern of the suprabasal layer of the skin" [MGI:cwg]
synonym: "disorganised suprabasal layer" EXACT []
is_a: MP:0001233 ! abnormal epidermis suprabasal layer morphology

[Term]
id: MP:0001236
name: abnormal epidermis stratum spinosum morphology
def: "any structural anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [ISBN:0-683-40008-8]
synonym: "abnormal prickle cell layer morphology" EXACT []
synonym: "abnormal spinous layer morphology" EXACT []
synonym: "abnormal stratum spinosum morphology" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001237
name: enlarged spinous cells
def: "increased size of the immature keratinocytes of the spinous layer of the epidermis" [PMID:18197786]
synonym: "enlarged prickle cells" EXACT []
synonym: "enlarged spinous cell size" EXACT []
synonym: "increased prickle cell size" EXACT []
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0001238
name: thin epidermis stratum spinosum
def: "reduced thickness of the stratum spinosum; the polyhedral cell layer" [ISBN:0-683-40008-8]
synonym: "thin epidermal spinous layer" RELATED []
synonym: "thin prickle cell layer" EXACT []
synonym: "thin spinous layer" EXACT []
synonym: "thin stratum spinosum" EXACT []
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0001239
name: abnormal epidermis stratum granulosum morphology
def: "any structural anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8]
synonym: "abnormal epidermal granular layer morphology" EXACT []
synonym: "abnormal granular layer morphology" BROAD []
synonym: "abnormal stratum granulosum morphology" BROAD []
synonym: "epidermal granular layer dysplasia" NARROW []
synonym: "epidermis stratum granulosum dysplasia" NARROW []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001240
name: abnormal epidermis stratum corneum morphology
def: "any structural anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [ISBN:0-683-40008-8]
synonym: "abnormal cornified layer morphology" EXACT []
synonym: "abnormal horny layer morphology" EXACT []
synonym: "abnormal stratum corneum morphology" EXACT []
synonym: "cornified layer dysplasia" NARROW []
synonym: "epidermis stratum corneum dysplasia" NARROW []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0001241
name: absent epidermis stratum corneum
def: "absence of the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [ISBN:0-683-40008-8]
synonym: "absence of cornified layer" EXACT []
synonym: "absent cornified layer" EXACT []
synonym: "absent horny layer" EXACT []
synonym: "absent stratum corneum" EXACT []
is_a: MP:0001240 ! abnormal epidermis stratum corneum morphology

[Term]
id: MP:0001242
name: hyperkeratosis
alt_id: MP:0001223
def: "thickening of the horny layer of the epidermis" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "epidermal hyperkeratosis" EXACT []
synonym: "thickened cornified layer" EXACT []
synonym: "thickened horny layer" EXACT []
synonym: "thickened stratum corneum" EXACT []
synonym: "thicker cornified layer" EXACT []
synonym: "thicker horny layer" EXACT []
synonym: "thicker stratum corneum" EXACT []
is_a: MP:0001240 ! abnormal epidermis stratum corneum morphology

[Term]
id: MP:0001243
name: abnormal dermal layer morphology
def: "any structural anomaly or atypical condition of the dermal layer of the skin" [ISBN:0-683-40008-8, PMID:10469309]
synonym: "abnormal corium morphology" EXACT []
synonym: "abnormal cutis vera morphology" EXACT []
synonym: "abnormal dermis morphology" EXACT []
synonym: "dermal layer dysplasia" NARROW []
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0001244
name: thin dermal layer
def: "reduced thickness of the dermis" [J:65030]
synonym: "thin corium" EXACT []
synonym: "thin cutis vera" EXACT []
synonym: "thin dermis" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0001245
name: thick dermal layer
def: "increased depth of the dermis" [J:65033]
synonym: "thick corium" EXACT []
synonym: "thick cutis vera" EXACT []
synonym: "thick dermis" EXACT []
synonym: "thickened corium" EXACT []
synonym: "thickened cutis vera" EXACT []
synonym: "thickened dermal layer" EXACT []
synonym: "thickened dermis" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0001246
name: mixed cellular infiltration to dermis
def: "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0001247
name: dermal cyst
def: "presence of one or more abnormal membranous sacs in the dermis" [J:53379]
synonym: "cystic dermis" EXACT []
synonym: "dermal cysts" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology
is_a: MP:0031309 ! skin cyst

[Term]
id: MP:0001248
name: obsolete absent connective tissue
def: "OBSOLETE. missing supporting framework of a tissue or the body; formed of fibrous or ground substance" [ISBN:0-683-40008-8, PMID:10469309]
synonym: "absence of connective tissue" EXACT []
is_obsolete: true

[Term]
id: MP:0001249
name: obsolete absent dermal adipose tissue
def: "OBSOLETE. missing fat associated with the skin layers" [PMID:7958926]
synonym: "absence of dermal adipose tissue" EXACT []
is_obsolete: true
consider: MP:0011156

[Term]
id: MP:0001251
name: dermis papillary layer hypercellularity
def: "increased cell density of the superficial layer" [PMID:10469309]
synonym: "hypercellularity of superficial dermis" EXACT []
synonym: "superficial dermis hypercellularity" RELATED []
is_a: MP:0009545 ! abnormal dermis papillary layer morphology

[Term]
id: MP:0001253
name: abnormal body height
def: "any anomaly in the shoulder to floor distance compared to controls" [MGI:dlb]
synonym: "abnormal height" EXACT []
xref: GO:0040007
xref: GO:0040014
is_a: MP:0003956 ! abnormal body size

[Term]
id: MP:0001254
name: increased body height
def: "increased shoulder to floor distance compared to controls" [MGI:dlb]
synonym: "increased height" EXACT []
is_a: MP:0001253 ! abnormal body height
is_a: MP:0001264 ! increased body size

[Term]
id: MP:0001255
name: decreased body height
alt_id: MP:0001269
def: "decreased shoulder to floor distance compared to controls" [MGI:dlb]
synonym: "decreased height" EXACT []
synonym: "reduced body height" EXACT []
synonym: "reduced height" EXACT []
synonym: "short stature" EXACT []
is_a: MP:0001253 ! abnormal body height
is_a: MP:0001265 ! decreased body size

[Term]
id: MP:0001256
name: abnormal body length
def: "any anomaly in the measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal length" EXACT []
is_a: MP:0003956 ! abnormal body size

[Term]
id: MP:0001257
name: increased body length
def: "increased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased length" EXACT []
is_a: MP:0001256 ! abnormal body length
is_a: MP:0001264 ! increased body size

[Term]
id: MP:0001258
name: decreased body length
def: "decreased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased length" EXACT []
synonym: "reduced body length" EXACT []
synonym: "reduced length" EXACT []
synonym: "short trunk" EXACT []
is_a: MP:0001256 ! abnormal body length
is_a: MP:0001265 ! decreased body size

[Term]
id: MP:0001259
name: abnormal body weight
def: "anomaly in average weight compared to controls" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal weight" EXACT []
is_a: MP:0003956 ! abnormal body size

[Term]
id: MP:0001260
name: increased body weight
def: "greater than normal average weight" [J:33400]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "high body weight" EXACT []
synonym: "increased weight" EXACT []
is_a: MP:0001259 ! abnormal body weight
is_a: MP:0001264 ! increased body size
is_a: MP:0012323 ! increased total tissue mass

[Term]
id: MP:0001261
name: obese
def: "a status with body weight that is grossly above the average, acceptable or desirable weight, usually due to accumulation of excess fat tissue in the body" [HP:0001513, MESH:D009765]
synonym: "obesity" EXACT []
is_a: MP:0001260 ! increased body weight

[Term]
id: MP:0001262
name: decreased body weight
def: "lower than normal average weight" [PMID:10709991]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased weight" EXACT []
synonym: "low body weight" EXACT []
synonym: "reduced body weight" EXACT []
synonym: "reduced weight" EXACT []
is_a: MP:0001259 ! abnormal body weight
is_a: MP:0001265 ! decreased body size
is_a: MP:0012322 ! decreased total tissue mass

[Term]
id: MP:0001263
name: weight loss
def: "progressive reduction of body weight below normal average for age" [PMID:9420327]
comment: This term should be used when weight is lost in the absence of external interventions.
is_a: MP:0001262 ! decreased body weight
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0001264
name: increased body size
def: "larger than average body weight, height and/or length of an organism compared to controls" [ISBN:0-683-40008-8, PMID:8646780]
synonym: "increased size" EXACT []
synonym: "large body size" EXACT []
xref: GO:0040007
xref: GO:0040014
is_a: MP:0003956 ! abnormal body size

[Term]
id: MP:0001265
name: decreased body size
def: "smaller than average body weight, height and/or length of an organism compared to controls" [ISBN:0-683-40008-8, PMID:7854452]
synonym: "decreased size" EXACT []
synonym: "dwarf" NARROW []
synonym: "reduced body size" EXACT []
synonym: "reduced size" EXACT []
synonym: "runt" EXACT []
synonym: "runted" EXACT []
synonym: "runting" EXACT []
synonym: "small body size" EXACT []
xref: GO:0040007
xref: GO:0040014
is_a: MP:0003956 ! abnormal body size

[Term]
id: MP:0001267
name: enlarged chest
def: "wider diameter, or distended chest cavity" [PMID:7926784]
synonym: "increased chest size" EXACT []
is_a: MP:0004134 ! abnormal chest morphology

[Term]
id: MP:0001268
name: barrel chest
def: "distended circumference of the thoracic and abdominal areas" [PMID:10572046]
is_a: MP:0001267 ! enlarged chest

[Term]
id: MP:0001270
name: distended abdomen
def: "abdomen appears curved outward or swollen" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "bulging abdomen" EXACT []
synonym: "protruding abdomen" EXACT []
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0001272
name: increased metastatic potential
def: "greater likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "elevated metastatic potential" EXACT []
synonym: "increase in metastasis potential" EXACT []
synonym: "increase in potential to develop metastases" EXACT []
is_a: MP:0000858 ! abnormal metastatic potential

[Term]
id: MP:0001273
name: decreased metastatic potential
def: "reduced likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced metastatic potential" EXACT []
synonym: "reduction in metastasis potential" EXACT []
synonym: "reduction in potential to develop metastases" EXACT []
is_a: MP:0000858 ! abnormal metastatic potential

[Term]
id: MP:0001274
name: curly vibrissae
alt_id: MP:0001275
def: "coiled or spiral shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [MESH:A13.950, PMID:9573048]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "curly contour hair" EXACT []
synonym: "curly sinus hair" EXACT []
synonym: "curly touch hair" EXACT []
synonym: "curly whiskers" EXACT []
synonym: "curved vibrissae" EXACT []
synonym: "curved whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001277
name: tangled vibrissae
def: "snarled or intertwined stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
subset: Europhenome_Terms
subset: IMPC
synonym: "tangled contour hair" EXACT []
synonym: "tangled sinus hair" EXACT []
synonym: "tangled touch hair" EXACT []
synonym: "tangled whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001278
name: kinked vibrissae
def: "sharp bends in the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [J:56641]
synonym: "kinked contour hair" EXACT []
synonym: "kinked sinus hair" EXACT []
synonym: "kinked touch hair" EXACT []
synonym: "kinked whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001279
name: wavy vibrissae
def: "undulations or a sinusoidal shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
synonym: "wavy contour hair" EXACT []
synonym: "wavy sinus hair" EXACT []
synonym: "wavy touch hair" EXACT []
synonym: "wavy whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001280
name: loss of vibrissae
def: "inability to retain the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [PMID:9420327]
synonym: "loss of contour hair" EXACT []
synonym: "loss of sinus hair" EXACT []
synonym: "loss of touch hair" EXACT []
synonym: "loss of whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001281
name: increased vibrissae length
def: "longer average length of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased contour hair length" EXACT []
synonym: "increased sinus hair length" EXACT []
synonym: "increased touch hair length" EXACT []
synonym: "increased whisker length" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001282
name: short vibrissae
def: "decreased length of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased contour hair length" EXACT []
synonym: "decreased sinus hair length" EXACT []
synonym: "decreased touch hair length" EXACT []
synonym: "decreased whisker length" EXACT []
synonym: "short contour hair" EXACT []
synonym: "short sinus hair" EXACT []
synonym: "short touch hair" EXACT []
synonym: "short whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001283
name: sparse vibrissae
def: "few and widely spaced stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
synonym: "sparse contour hair" EXACT []
synonym: "sparse sinus hair" EXACT []
synonym: "sparse touch hair" EXACT []
synonym: "sparse whiskers" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001284
name: absent vibrissae
def: "absence of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950, PMID:7958926]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "absence of vibrissae" EXACT []
synonym: "absence of whiskers" RELATED []
synonym: "absent contour hair" EXACT []
synonym: "absent sinus hair" EXACT []
synonym: "absent touch hair" EXACT []
synonym: "absent whiskers" RELATED []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0001286
name: abnormal eye development
def: "malformation or arrest of differentiation of the visual organ" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
subset: IMPC
subset: Sanger_Terms
synonym: "eye development abnormalities" EXACT []
xref: GO:0001654
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0001288
name: abnormal lens induction
def: "any anomaly in the signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens" [GO:0060235]
synonym: "lens induction abnormalities" EXACT []
is_a: MP:0005545 ! abnormal lens development

[Term]
id: MP:0001289
name: persistence of hyaloid vascular system
def: "failure of the degeneration of the transient vascular system of the eye during development, that normally nourishes the retina, immature lens and primary vitreous of the developing eye" [PMID:18841878]
subset: IMPC
subset: Sanger_Terms
synonym: "persistence of hyaloid capillary system" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0002699 ! abnormal vitreous body morphology

[Term]
id: MP:0001290
name: delayed eyelid opening
def: "late average time for the first postnatal eye opening" [J:17792]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later.
synonym: "delayed eye lid opening" EXACT []
synonym: "delayed eye opening" EXACT []
is_a: MP:0004874 ! abnormal timing of postnatal eyelid opening

[Term]
id: MP:0001292
name: abnormal lens vesicle development
def: "malformation or abnormal patterning of the ectodermal invagination that forms opposite the optic cup in the primordium of the lens of the eye" [ISBN:0-12-402035-6]
synonym: "lens vesicle development abnormalities" EXACT []
synonym: "lenticular vesicle development" RELATED []
is_a: MP:0001288 ! abnormal lens induction

[Term]
id: MP:0001293
name: anophthalmia
alt_id: MP:0001298
def: "absence of the globe and ocular tissue from the orbit, with or without the presence of ocular adnexa (eyelids, conjunctiva, and lacrimal apparatus); remnants of the globe sometimes appear in ectopic locations" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "absence of eyes" EXACT []
synonym: "absent eyes" EXACT []
synonym: "eyeless" EXACT []
xref: Fyler:4864
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0001296
name: macrophthalmia
def: "increased average size of the eyes" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "big eyes" EXACT []
synonym: "enlarged eyes" EXACT []
synonym: "increased eye size" EXACT []
synonym: "macrophthalamos" EXACT []
is_a: MP:0002697 ! abnormal eye size

[Term]
id: MP:0001297
name: microphthalmia
def: "reduced average size of one or both eyes; generally refers to a congenital defect" [PMID:7926784]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "decreased eye size" EXACT []
synonym: "microphthalmos" EXACT []
synonym: "small eyes" EXACT []
xref: Fyler:4877
is_a: MP:0002697 ! abnormal eye size

[Term]
id: MP:0001299
name: abnormal eye distance/ position
def: "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [https://orcid.org/0000-0003-3691-0324]
synonym: "eye distance/ position abnormalities" EXACT []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0001300
name: ocular hypertelorism
def: "increased interpupillary distance, i.e. increased distance between the center of the pupils of the two eyes" [HP:0000316, PMID:19125427]
synonym: "excessive orbital separation" EXACT []
synonym: "increased distance between the eye sockets" EXACT []
synonym: "increased distance between the eyes" EXACT []
synonym: "increased interorbital distance" EXACT []
synonym: "wide set eyes" EXACT []
synonym: "wide-set eyes" EXACT []
synonym: "widely spaced eyes" EXACT []
synonym: "widened interpupillary distance" EXACT []
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0001301
name: obsolete abnormal eye movement
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "eye movement abnormalities" EXACT []
is_obsolete: true
consider: MP:0001389

[Term]
id: MP:0001302
name: eyelids open at birth
alt_id: MP:0001342
def: "open eyes instead of closed at perinatal stage; failure of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye to fuse completely together during development and an individual is born with the eye(s) uncovered leading to degrees of injury and blindness" [MGI:llw2]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later.
synonym: "open eye lids" EXACT []
synonym: "open eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0001303
name: abnormal lens morphology
def: "any structural anomaly of the transparent structure of the eye responsible for focusing light rays" [ISBN:0-683-40008-8, PMID:9144284]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "lens abnormalities" BROAD []
synonym: "lens dysplasia" NARROW []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0001304
name: cataract
def: "complete or partial opacity of the lens" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "cataracts" EXACT []
synonym: "cataracts/ lens opacity" EXACT []
synonym: "lens opacity" EXACT []
xref: Fyler:4865
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0001305
name: enlarged lens
def: "increased size of the transparent structure of the eye responsible for focusing light rays" [ISBN:0-683-40008-8]
synonym: "increased lens size" EXACT []
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0001306
name: small lens
def: "reduced size of the transparent structure of the eye responsible for focusing light rays" [ISBN:0-683-40008-8, PMID:9753320]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased lens size" EXACT []
synonym: "microphakia" EXACT []
synonym: "reduced lens size" EXACT []
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0001307
name: fused cornea and lens
alt_id: MP:0001315
def: "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [ISBN:0-683-40008-8]
synonym: "cornea and lens fusion" EXACT []
synonym: "cornea/lens fusion" EXACT []
synonym: "fused cornea/lens" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
is_a: MP:0005545 ! abnormal lens development

[Term]
id: MP:0001308
name: abnormal lens polarity
def: "failure of normal orientation of the lens during development" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:9753320]
synonym: "abnormal lens polarization" EXACT []
is_a: MP:0020486 ! abnormal lens topology

[Term]
id: MP:0001309
name: hydropic eye lens fibers
def: "swollen cortical fibers of the eye lens" [J:14285]
synonym: "hydropic eye lens fibres" EXACT []
is_a: MP:0002840 ! abnormal lens fiber morphology

[Term]
id: MP:0001310
name: abnormal conjunctiva morphology
def: "any structural anomaly of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball" [https://orcid.org/0000-0003-3691-0324, MESH:A09.371.060.200]
synonym: "conjunctiva abnormalities" BROAD []
synonym: "conjunctival dysplasia" NARROW []
is_a: MP:0005193 ! abnormal anterior eye segment morphology
is_a: MP:0013754 ! abnormal ocular surface morphology

[Term]
id: MP:0001312
name: abnormal cornea morphology
def: "any structural anomaly of the transparent anterior portion of the fibrous coat of the eye that covers the iris, pupil, and anterior chamber; together with the lens, the cornea refracts light" [ISBN:0-683-40008-8, UBERON:0000964]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cornea of camera-type eye morphology" BROAD []
synonym: "abnormal corneal morphology" EXACT []
synonym: "abnormal tarsal conjunctiva morphology" EXACT []
synonym: "abnormal tunica cornea morphology" EXACT []
synonym: "cornea abnormalities" BROAD []
synonym: "corneal dysplasia" NARROW []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0001313
name: increased incidence of corneal inflammation
def: "greater than average occurrence and/or persistence of the local accumulation of fluid, plasma proteins, and leukocytes in the cornea" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased incidence of keratitis" BROAD []
synonym: "increased incidence of tunica cornea inflammation" EXACT []
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0001314
name: cornea opacity
def: "complete or partial clouding of the cornea" [ISBN:0-683-40008-8, MGI:jte]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "corneal opacity" EXACT []
synonym: "tunica cornea opacity" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0001316
name: cornea scarring
def: "appearance of fibrous tissue on the cornea after healing in response to injury" [J:30249]
synonym: "corneal scarring" EXACT []
synonym: "tunica cornea scarring" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0001317
name: abnormal pupil morphology
def: "any structural anomaly of the central circular aperture of the iris through which light rays enter the eye" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "pupil abnormalities" BROAD []
synonym: "pupil dysplasia" NARROW []
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0001318
name: pupil opacity
def: "milky or cloudy appearance of the central circular aperture of the iris through which light rays normally enter the eye" [ISBN:0-683-40008-8]
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0001319
name: irregularly shaped pupil
def: "shape defects in the aperture of the iris through which light rays enter the eye, usually circular" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0001320
name: small pupil
def: "smaller than normal size of the central circular aperture of the iris through which light rays enter the eye" [ISBN:0-683-40008-8]
synonym: "decreased pupil size" EXACT []
synonym: "reduced pupil size" EXACT []
synonym: "small pupils" EXACT []
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0001322
name: abnormal iris morphology
alt_id: MP:0006227
def: "any structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "iris abnormalities" BROAD []
synonym: "iris dysplasia" NARROW []
is_a: MP:0005194 ! abnormal anterior uvea morphology

[Term]
id: MP:0001323
name: obsolete iris opacity
def: "OBSOLETE. milky or cloudy iris that is impervious to light" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001324
name: abnormal eye pigmentation
def: "change in the normal pigmentation of the eye to another color, or lack of color" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal eye color" NARROW []
synonym: "abnormal eye colour" NARROW []
synonym: "abnormal ocular pigmentation" EXACT []
is_a: MP:0002092 ! abnormal eye morphology
is_a: MP:0009389 ! abnormal extracutaneous pigmentation

[Term]
id: MP:0001325
name: abnormal retina morphology
def: "any structural anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal retinal morphology" EXACT []
synonym: "retina abnormalities" BROAD []
synonym: "retina dysplasia" NARROW []
synonym: "retinal abnormalities" BROAD []
synonym: "retinal dysplasia" NARROW []
is_a: MP:0002864 ! abnormal ocular fundus morphology

[Term]
id: MP:0001326
name: retina degeneration
def: "retrogressive pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [ISBN:0-683-40008-8, MGI:pretel]
subset: Europhenome_Terms
subset: IMPC
synonym: "retinal degeneration" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0001327
name: decreased retina photoreceptor cell number
def: "fewer than the expected number of rods and/or cones" [MGI:cwg]
synonym: "decreased retinal photoreceptor cell number" EXACT []
synonym: "reduced number of retinal photoreceptor cells" EXACT []
synonym: "reduced retina photoreceptor cell number" EXACT []
synonym: "reduced retinal photoreceptor cell number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0001004 ! abnormal retina photoreceptor morphology

[Term]
id: MP:0001328
name: disorganized retina layers
def: "derangement of the pattern of the sheets of cells comprising the optic part of the retina" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
synonym: "disorganised retinal layers" EXACT []
is_a: MP:0003727 ! abnormal retina layer morphology

[Term]
id: MP:0001329
name: retina hyperplasia
def: "increase in the number of normal cells in normal arrangement in the retina, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic retina" EXACT []
synonym: "retinal hyperplasia" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0001330
name: abnormal optic nerve morphology
alt_id: MP:0001058
alt_id: MP:0001287
def: "any structural anomaly of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CN-II morphology" EXACT []
synonym: "abnormal optic II nerve morphology" EXACT []
synonym: "optic nerve abnormalities" BROAD []
synonym: "optic nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology
is_a: MP:0005195 ! abnormal posterior eye segment morphology

[Term]
id: MP:0001332
name: abnormal optic nerve innervation
alt_id: MP:0001060
def: "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "optic nerve innervation abnormalities" EXACT []
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0001333
name: absent optic nerve
def: "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent CN-II nerve" EXACT []
synonym: "absent optic II nerve" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0001334
name: absent optic tract
def: "absence of the band of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region" [ISBN:0-683-40008-8]
is_a: MP:0004267 ! abnormal optic tract morphology

[Term]
id: MP:0001335
name: obsolete Subject to Infection
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001336
name: obsolete increased incidence of inflamed eyes
def: "OBSOLETE. greater than normal frequency of inflammatory response in the eyes" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001851

[Term]
id: MP:0001337
name: dry eyes
def: "absence of natural or normal moisture in the eye" [J:53284]
synonym: "xerophthalmia" EXACT []
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0001340
name: abnormal eyelid morphology
def: "any structural anomaly of the skin folds covering the front of the eyeball" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal blephara morphology" EXACT []
synonym: "abnormal blepharon morphology" EXACT []
synonym: "abnormal eye lid morphology" EXACT []
synonym: "abnormal eyelids morphology" EXACT []
synonym: "abnormal palpebra morphology" EXACT []
synonym: "abnormal palpebrae morphology" EXACT []
synonym: "eyelid abnormalities" BROAD []
synonym: "eyelid dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0001341
name: absent eyelids
def: "missing skin folds covering the front of the eyeball when closed" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "ablepharia" EXACT []
synonym: "ablepharon" EXACT []
synonym: "absent blephara" EXACT []
synonym: "absent blepharon" EXACT []
synonym: "absent eye lids" EXACT []
synonym: "absent palpebra" EXACT []
synonym: "absent palpebrae" EXACT []
synonym: "eyelid agenesis" EXACT []
synonym: "eyelid aplasia" EXACT []
synonym: "missing eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0001343
name: pronounced eyelids
def: "strongly protruding eyelids" [J:65032]
synonym: "bulgy eyelids" EXACT []
synonym: "pronounced eye lids" EXACT []
synonym: "protruding eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0001344
name: blepharoptosis
alt_id: MP:0006161
def: "ptosis, drooping eyelids" [ISBN:0-683-40008-8]
synonym: "drooping eye lids" EXACT []
synonym: "drooping eyelids" EXACT []
synonym: "palpebraoptosis" EXACT []
synonym: "ptosis" EXACT []
synonym: "ptosis of the eye" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0001345
name: Meibomian gland atrophy
alt_id: MP:0000651
def: "acquired diminution of the size of the sebaceous glands embedded in the tarsal plate of each eyelid, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, PMID:8941642]
synonym: "atrophic glandulae tarsales" EXACT []
synonym: "atrophic meibomian glands" EXACT []
synonym: "atrophic palpebral glands" EXACT []
synonym: "atrophic tarsal glands" EXACT []
is_a: MP:0013388 ! small Meibomian gland

[Term]
id: MP:0001346
name: abnormal lacrimal gland morphology
alt_id: MP:0000682
def: "any structural anomaly of the glands that secrete tears" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal lachrymal glands morphology" EXACT []
synonym: "lacrimal gland dysplasia" NARROW []
is_a: MP:0008968 ! abnormal lacrimal apparatus morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0001347
name: absent lacrimal glands
alt_id: MP:0000684
def: "missing the glands that secrete tears" [ISBN:0-683-40008-8, MGI:tc]
synonym: "absence of lachrymal glands" EXACT []
synonym: "absence of lacrimal glands" EXACT []
synonym: "lacrimal gland aplasia" EXACT []
synonym: "loss of lachrymal glands" BROAD []
synonym: "loss of lacrimal glands" BROAD []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0001348
name: abnormal lacrimal gland physiology
def: "any functional anomaly of the glands that secrete tears" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0013450 ! abnormal lacrimal apparatus physiology
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0001349
name: excessive tearing
def: "an unusually high amount of fluid in the eye, either oversecreted by the lacrimal glands, or due to imperfect drainage by the tear conducting passages, often resulting in overflow of fluid from the eye onto the cheek" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "epiphora" EXACT []
synonym: "excessive lachrymation" EXACT []
synonym: "excessive lacrimation" EXACT []
synonym: "lacrimous eye" NARROW []
synonym: "watering eye" EXACT []
is_a: MP:0020218 ! abnormal tear production

[Term]
id: MP:0001353
name: increased aggression towards mice
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
synonym: "aggression to other mice" EXACT []
synonym: "increased aggression to other mice" EXACT []
is_a: MP:0005655 ! increased aggression
is_a: MP:0021115 ! abnormal aggression towards conspecific

[Term]
id: MP:0001354
name: increased aggression towards male mice
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
synonym: "aggression towards males" EXACT []
is_a: MP:0001353 ! increased aggression towards mice

[Term]
id: MP:0001355
name: submission towards male mice
def: "no domineering, assault posture nor hostile physical action toward male mice" [ISBN:0-395-70869-9, ISBN:0-683-40008-8, PMID:10716451]
synonym: "lack of aggression towards males" EXACT []
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior
is_a: MP:0005656 ! decreased aggression

[Term]
id: MP:0001356
name: increased aggression towards female mice
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
synonym: "aggression towards females" EXACT []
is_a: MP:0001353 ! increased aggression towards mice

[Term]
id: MP:0001357
name: increased aggression towards humans
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
synonym: "aggression to humans" EXACT []
synonym: "increased aggression to humans" EXACT []
is_a: MP:0005655 ! increased aggression

[Term]
id: MP:0001358
name: aggression towards inanimate objects
def: "a domineering, assault posture and/or hostile physical action toward inanimate objects" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "aggression to inanimate objects" EXACT []
is_a: MP:0005655 ! increased aggression

[Term]
id: MP:0001359
name: obsolete piling
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001360
name: abnormal social investigation
def: "altered behavior of animals to approach and examine conspecifics" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior

[Term]
id: MP:0001361
name: social withdrawal
def: "reclusive behavior; the tendency to refrain from participating in social situations and to seek isolation" [https://orcid.org/0000-0003-3691-0324]
comment: In mice, one sign of this phenotype is that animals will remain physically distant, and do not sleep in piles with cagemates.
is_a: MP:0021111 ! decreased social investigation

[Term]
id: MP:0001362
name: abnormal anxiety-related response
def: "altered emotional response related to anticipation of a non-specific threat" [https://orcid.org/0000-0003-3691-0324, MGI:CFG]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal anxiety response" EXACT []
synonym: "altered anxiety response" EXACT []
is_a: MP:0002065 ! abnormal fear/anxiety-related behavior

[Term]
id: MP:0001363
name: increased anxiety-related response
def: "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [MGI:cwg]
synonym: "elevated anxiety" EXACT []
synonym: "increased anxiety" EXACT []
is_a: MP:0001362 ! abnormal anxiety-related response

[Term]
id: MP:0001364
name: decreased anxiety-related response
alt_id: MP:0001367
alt_id: MP:0001368
alt_id: MP:0002197
def: "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [MGI:cwg]
synonym: "decreased anxiety" EXACT []
synonym: "reduced anxiety" EXACT []
synonym: "reduced anxiety in dark-light crossing task" EXACT []
synonym: "reduced anxiety in elevated plus maze test" EXACT []
synonym: "reduced anxiety in elevated zero maze test" EXACT []
is_a: MP:0001362 ! abnormal anxiety-related response

[Term]
id: MP:0001365
name: obsolete increased escape behavior induced by intruder mouse
def: "OBSOLETE. resident animals exhibit escape behavior and do not initiate social investigation of an intruder mouse" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001366
name: obsolete impaired stress response in porsolt forced swin test
def: "OBSOLETE. reduced freezing behavior resulting from failed escape attempts induced by forced swim in a small cylinder" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3, PMID:10471508]
is_obsolete: true

[Term]
id: MP:0001373
name: obsolete Increased Fecundity
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001375
name: abnormal mating preference
def: "any change from the common preference of an initiating organism to initiate sexual contact with a receptive partner; in rodents, this usually refers to males that attempts to initiate sexual behavior with males and females indiscriminately" [J:76339]
is_a: MP:0002566 ! abnormal sexual interaction

[Term]
id: MP:0001376
name: abnormal mating receptivity
def: "deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468]
synonym: "abnormal lordosis behavior" EXACT []
is_a: MP:0002566 ! abnormal sexual interaction

[Term]
id: MP:0001377
name: abnormal mating frequency
def: "increased, reduced or absent attempt of sexual behavioral contact between an initiating organism and a receptive partner" [MESH:F01.145.113.252.748.200]
synonym: "abnormal coitus frequency" EXACT []
synonym: "abnormal copulation frequency" BROAD []
is_a: MP:0002566 ! abnormal sexual interaction

[Term]
id: MP:0001378
name: abnormal ejaculation
def: "anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior" [ISBN:0-683-40008-8]
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0001379
name: abnormal penile erection
def: "altered ability to achieve a rigid state of the penis obtained in the condition in which the erectile tissue is filled with blood" [ISBN:0-683-40008-8]
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0031627 ! abnormal copulation physiology

[Term]
id: MP:0001380
name: decreased male mating frequency
def: "males do not as frequently initiate sexual behavior (as scored by the presence of copulation plugs in rodents, not due to infertility)" [J:57125]
synonym: "male reduced copulation" RELATED []
synonym: "male reduced copulation without impotence" RELATED []
synonym: "male sexual dysfunction, without impotence" RELATED []
synonym: "reduced male mating frequency" EXACT []
is_a: MP:0014601 ! decreased mating frequency

[Term]
id: MP:0001382
name: abnormal nursing
def: "females show anomlies in the feeding of offspring from mammary glands, or do not nurse offspring, or nurse offspring infrequently" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001386 ! abnormal maternal nurturing

[Term]
id: MP:0001384
name: abnormal pup retrieval
def: "any anomaly in the ability of a nesting female to retrieve stray pups to the nest or a delay in retrieving stray pups" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009731 ! abnormal offspring retrieval

[Term]
id: MP:0001385
name: pup cannibalization
def: "the killing and eating of newborn mice by the mother; however, this can be a normal response if the mother does not recognize the pups as her own" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001386 ! abnormal maternal nurturing

[Term]
id: MP:0001386
name: abnormal maternal nurturing
alt_id: MP:0001381
def: "anomaly in the behaviors related to a female tending to young" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal care for newborns" EXACT []
synonym: "maternal nurturing defect" EXACT []
is_a: MP:0008779 ! abnormal maternal behavior

[Term]
id: MP:0001387
name: obsolete abnormal movement/ locomotion
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "movement/ locomotion abnormalities" EXACT []
is_obsolete: true
consider: MP:0002066

[Term]
id: MP:0001388
name: abnormal stationary movement
def: "altered ability or inability to change body posture or shift a body part" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal body part movement" EXACT []
synonym: "stationary movement abnormalities" EXACT []
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0001389
name: abnormal eye movement
def: "deviation from the normal motility of the visual organs" [MGI:cwg]
is_a: MP:0001388 ! abnormal stationary movement
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0001391
name: abnormal tail movements
alt_id: MP:0000590
def: "a change from the normal manner of moving the tail" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001388 ! abnormal stationary movement

[Term]
id: MP:0001392
name: abnormal locomotor behavior
def: "altered ability or inability to move from place to place in response to stimuli" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal locomotion" EXACT []
synonym: "abnormal locomotor activity" EXACT []
synonym: "abnormal locomotor behaviour" EXACT []
synonym: "abnormal locomotory behavior" EXACT []
synonym: "abnormal locomotory behaviour" EXACT []
is_a: MP:0003491 ! abnormal voluntary movement

[Term]
id: MP:0001393
name: ataxia
def: "inability to coordinate voluntary muscular movements" [ISBN:0-683-40008-8]
synonym: "unsteady gait" RELATED []
is_a: MP:0001516 ! abnormal motor coordination/balance
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0001394
name: circling
def: "repeated movement in a circle; often associated with inner ear defects" [https://orcid.org/0000-0003-3691-0324, PMID:10709991]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0001395
name: bidirectional circling
def: "circling behavior exhibited in both clockwise and counterclockwise directions" [MGI:cml]
is_a: MP:0001394 ! circling

[Term]
id: MP:0001396
name: unidirectional circling
def: "circling behavior in one direction only, either clockwise or counterclockwise" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0001394 ! circling

[Term]
id: MP:0001398
name: obsolete backflips
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001399
name: hyperactivity
alt_id: MP:0001397
alt_id: MP:0001403
def: "general restlessness or excessive movement; more frequent movement from one place to another or having an increased state of activity" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "hyperactive" EXACT []
synonym: "increased physical activity" EXACT []
synonym: "restless" RELATED []
is_a: MP:0003491 ! abnormal voluntary movement

[Term]
id: MP:0001400
name: hyperresponsive
def: "increased reaction to touch" [J:39801]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002067 ! abnormal sensory capabilities/reflexes/nociception

[Term]
id: MP:0001401
name: jumpy
def: "marked by fitful, jerky movements" [J:22295]
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0001402
name: decreased locomotor activity
alt_id: MP:0001419
def: "general reduction in locomotor activity; reduced movement from one place to another" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased spontaneous locomotor activity" EXACT []
synonym: "hypolocomotion" EXACT []
synonym: "low spontaneous locomotor activity" EXACT []
synonym: "reduced activity in horizontal open field test" NARROW []
synonym: "reduced locomotor activity" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior
is_a: MP:0031392 ! hypoactivity

[Term]
id: MP:0001404
name: no spontaneous movement
def: "failure of neonates or embryos to initiate any voluntary or spontaneous change in position or posture, with or without external stimulus" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "failure to move" EXACT []
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0001405
name: impaired coordination
alt_id: MP:0001517
alt_id: MP:0001518
alt_id: MP:0001519
alt_id: MP:0001520
alt_id: MP:0001521
def: "reduced ability to execute integrated movements of muscle" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "impaired motor coordination" EXACT []
synonym: "impaired motor coordination in balance beam test" NARROW []
synonym: "impaired motor coordination in hanging wire test" NARROW []
synonym: "impaired motor coordination in platform test" NARROW []
synonym: "impaired motor coordination in rotarod test" NARROW []
synonym: "impaired motor coordination in thin rod test" NARROW []
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0001406
name: abnormal gait
def: "abnormal pattern of movement of the limbs of animals, characterized by elements of progression, stability, speed and length over the ground" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal ambulation" EXACT []
synonym: "peculiar gait" EXACT []
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0001407
name: short stride length
def: "reduced average distance between steps" [J:34193]
is_a: MP:0012690 ! abnormal stride length

[Term]
id: MP:0001408
name: stereotypic behavior
def: "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [ISBN:0-471-31639-3]
subset: IMPC
subset: Sanger_Terms
synonym: "stereotypic behaviour" EXACT []
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0001409
name: increased stereotypic behavior
def: "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3]
synonym: "increased stereotypic behaviour" EXACT []
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0001410
name: head bobbing
def: "repetitive up and down movement of the head" [J:17123]
synonym: "head nodding" EXACT []
is_a: MP:0000436 ! abnormal head movements
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0001411
name: spinning
def: "repetitive rolling of the body" [J:17123]
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0001412
name: excessive scratching
def: "compulsive scraping of the skin, usually with the nails" [J:61340]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001408 ! stereotypic behavior
is_a: MP:0001440 ! abnormal grooming behavior

[Term]
id: MP:0001413
name: abnormal response to new environment
def: "altered behavioral reaction associated with placing an animal in a new location" [MGI:CFG]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal transfer arousal" EXACT []
synonym: "transfer arousal" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning
is_a: MP:0003107 ! abnormal response to novelty

[Term]
id: MP:0001414
name: obsolete Increased Response to New Environment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001415
name: increased exploration in new environment
def: "greater amount of time spent investigating new location" [J:28825]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0013189 ! abnormal exploration in a new environment

[Term]
id: MP:0001416
name: obsolete Decreased Response to New Environment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001417
name: decreased exploration in new environment
def: "less amount of time spent investigating a new location" [ISBN:0471316393]
subset: Europhenome_Terms
subset: IMPC
synonym: "neophobia" EXACT []
synonym: "reduced exploration in new environment" EXACT []
is_a: MP:0013189 ! abnormal exploration in a new environment

[Term]
id: MP:0001418
name: obsolete open field locomotion abnormalities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001421
name: obsolete touch escape
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001422
name: abnormal drinking behavior
alt_id: MP:0003911
alt_id: MP:0003912
def: "an altered pattern of fluid consumption or altered preference for particular fluids" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal drinking behaviour" EXACT []
is_a: MP:0002069 ! abnormal consumption behavior

[Term]
id: MP:0001423
name: abnormal liquid preference
def: "the desire to drink more or less fluids than average, or to drink unusual fluids" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001422 ! abnormal drinking behavior

[Term]
id: MP:0001424
name: obsolete abnormal water consumption
def: "OBSOLETE. drinking water in anomalous quantities" [MGI:cwg]
is_obsolete: true
consider: MP:0001422

[Term]
id: MP:0001425
name: abnormal alcohol consumption
def: "aberrant behavioral-related or physiological-related intake of alcohol into the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ethanol consumption" EXACT []
is_a: MP:0001422 ! abnormal drinking behavior
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0001426
name: polydipsia
def: "abnormally large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "excessive drinking" EXACT []
synonym: "increased drinking" EXACT []
synonym: "polydypsia" EXACT []
is_a: MP:0011941 ! increased fluid intake

[Term]
id: MP:0001428
name: adipsia
alt_id: MP:0001427
def: "failure to drink" [ISBN:0-683-40008-8]
is_a: MP:0001422 ! abnormal drinking behavior

[Term]
id: MP:0001429
name: dehydration
def: "excessive water loss from the body or from an organ or bodily part" [ISBN:0-683-40008-8, PMID:9744866]
is_a: MP:0001784 ! abnormal fluid regulation

[Term]
id: MP:0001431
name: abnormal eating behavior
alt_id: MP:0001430
alt_id: MP:0003909
alt_id: MP:0003910
def: "altered ability to consume foods or atypical consumption pattern" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal eating behaviour" EXACT []
synonym: "abnormal feeding" EXACT []
synonym: "abnormal feeding behavior" EXACT []
synonym: "abnormal feeding behaviour" EXACT []
is_a: MP:0002069 ! abnormal consumption behavior

[Term]
id: MP:0001432
name: abnormal food preference
def: "the desire to eat more or less food than average, or to eat unusual foods" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001431 ! abnormal eating behavior

[Term]
id: MP:0001433
name: polyphagia
def: "eating to excess" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "hyperphagia" EXACT []
synonym: "over eating" EXACT []
is_a: MP:0011939 ! increased food intake

[Term]
id: MP:0001435
name: absent suckling reflex
def: "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
synonym: "absent rooting reflex" EXACT []
synonym: "absent rooting response" EXACT []
synonym: "no suckling reflex" EXACT []
is_a: MP:0020863 ! abnormal suckling reflex

[Term]
id: MP:0001436
name: abnormal suckling behavior
def: "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
synonym: "abnormal sucking behavior" EXACT []
synonym: "abnormal sucking behaviour" EXACT []
synonym: "abnormal suckling behaviour" EXACT []
is_a: MP:0001431 ! abnormal eating behavior

[Term]
id: MP:0001437
name: no swallowing reflex
def: "inability to pull food through the esophagus to the stomach in response to feeding" [J:56847]
is_a: MP:0001436 ! abnormal suckling behavior

[Term]
id: MP:0001438
name: aphagia
alt_id: MP:0001434
def: "failure to eat" [ISBN:0-683-40008-8]
is_a: MP:0005449 ! abnormal food intake

[Term]
id: MP:0001440
name: abnormal grooming behavior
alt_id: MP:0001439
def: "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal grooming" EXACT []
synonym: "abnormal grooming behaviour" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0001441
name: increased grooming behavior
def: "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased grooming behaviour" EXACT []
is_a: MP:0001440 ! abnormal grooming behavior

[Term]
id: MP:0001442
name: decreased grooming behavior
def: "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased grooming behaviour" EXACT []
synonym: "reduced grooming behavior" EXACT []
synonym: "reduced grooming behaviour" EXACT []
is_a: MP:0001440 ! abnormal grooming behavior

[Term]
id: MP:0001443
name: poor grooming
def: "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [https://orcid.org/0000-0003-3691-0324, J:30404]
is_a: MP:0001440 ! abnormal grooming behavior

[Term]
id: MP:0001444
name: obsolete compulsive biting
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001445
name: obsolete compulsive licking
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001446
name: abnormal whisker trimming behavior
def: "anomaly in the behavior of plucking or biting off of the whiskers/vibrissae from other individuals of a cohort" [https://orcid.org/0000-0003-3691-0324, MGI:il, PMID:16236465]
comment: This is a rodent-specific behavior. Whisker trimming and barbering are either normal or abnormal depending on the mouse strain. Barbering is particularly common in C57BL/6 and A2G but nearly unseen in other strains. This term should always be used in relation to the control and strain should be specified.
synonym: "abnormal whisker trimming behaviour" EXACT []
is_a: MP:0011000 ! abnormal allogrooming behavior

[Term]
id: MP:0001447
name: abnormal nest building behavior
def: "deviation from the usual behavior of nesting animals to build sleeping nests out of any available materials, or of nesting animals to build nests to protect offspring" [ISBN:0-471-31639-3]
synonym: "abnormal nest building behaviour" EXACT []
is_a: MP:0002068 ! abnormal parental behavior

[Term]
id: MP:0001448
name: obsolete abnormal mouse huddling behavior
def: "OBSOLETE:any anomaly in the the usual tendency of mice to pile together when sleeping" [ISBN:0-471-31639-3]
synonym: "abnormal huddling behaviour" EXACT []
is_obsolete: true
replaced_by: MP:0021117

[Term]
id: MP:0001450
name: obsolete Altered Intelligence
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001451
name: obsolete Decreased Intelligence
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001452
name: obsolete Increased Intelligence
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001454
name: abnormal cued conditioning behavior
alt_id: MP:0001453
def: "anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:CFG]
synonym: "abnormal context-trace conditioning" EXACT []
synonym: "abnormal cued conditioning behaviour" EXACT []
synonym: "cued conditioning anomalies" EXACT []
synonym: "cued fear conditioning abnormalities" EXACT []
synonym: "fear conditioning abnormalities" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0001455
name: obsolete normal cued fear conditioning
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001456
name: obsolete impaired long term memory in cued fear conditioning test
def: "OBSOLETE. altered ability to recall an association between an auditory cue and a foot shock over time; measured by \"freezing\" of animal in response to auditory cue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3, PMID:9949198]
is_obsolete: true
consider: MP:0001454
consider: MP:0002063

[Term]
id: MP:0001457
name: obsolete impaired long term memory in contextual fear test
def: "OBSOLETE. altered ability to recall an association between a location and a foot shock over time; measured by \"freezing\" of animal in response to auditory cue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3]
is_obsolete: true
consider: MP:0001469
consider: MP:0002063

[Term]
id: MP:0001458
name: abnormal object recognition memory
def: "anomaly in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [MGI:CFG]
synonym: "object recognition memory abnormalities" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0001459
name: obsolete impaired memory in novel object recognition test
def: "OBSOLETE. reduced time spent exploring a novel object that replaced a training object after a specified retention time" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001458

[Term]
id: MP:0001460
name: abnormal olfactory discrimination memory
def: "anomaly in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [MGI:CFG]
synonym: "olfactory discrimination memory abnormalities" EXACT []
is_a: MP:0002802 ! abnormal discrimination learning

[Term]
id: MP:0001461
name: obsolete impaired memory in olfactory discrimination test
def: "OBSOLETE. reduced food preference based on food recently smelled on the breath of other individuals" [ISBN:0-471-31639-3]
is_obsolete: true
consider: MP:0001460

[Term]
id: MP:0001462
name: abnormal avoidance learning behavior
def: "anomaly in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [MGI:CFG]
synonym: "abnormal avoidance learning behaviour" EXACT []
synonym: "avoidance learning anomalies" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0001463
name: abnormal spatial learning
alt_id: MP:0001466
alt_id: MP:0001467
def: "anomaly in the ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [https://orcid.org/0000-0003-3691-0324, MGI:CFG]
synonym: "spatial learning abnormalities" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0001464
name: obsolete impaired learning in eight arm radial maze test
def: "OBSOLETE. reduced ability to remember a sequence of previously visited feeding sites in an eight arm maze" [ISBN:0-471-31639-3]
is_obsolete: true
consider: MP:0008414
consider: MP:0008428

[Term]
id: MP:0001465
name: obsolete morris water maze
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001468
name: abnormal temporal memory
def: "anomaly in the ability to recall temporal events and stimuli" [MGI:CFG]
synonym: "temporal memory abnormalities" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0001469
name: abnormal contextual conditioning behavior
def: "anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:CFG]
synonym: "abnormal contextual conditioning behaviour" EXACT []
synonym: "abnormal contextual fear conditioning" EXACT []
synonym: "contextual conditioning anomalies" EXACT []
synonym: "contextual fear conditioning abnormalities" EXACT []
is_a: MP:0001468 ! abnormal temporal memory
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0001470
name: obsolete impaired long term memory in step-down avoidance test
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001469

[Term]
id: MP:0001471
name: obsolete large place fields
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001473
name: reduced long-term potentiation
def: "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [ISBN:0838580343]
synonym: "deficient long term potentiation" EXACT []
synonym: "deficient LTP" EXACT []
synonym: "reduced long term potentiation" EXACT []
is_a: MP:0002207 ! abnormal long-term potentiation

[Term]
id: MP:0001475
name: reduced long-term depression
def: "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "deficient long term depression" EXACT []
synonym: "deficient LTD" EXACT []
synonym: "reduced long term depression" EXACT []
is_a: MP:0001898 ! abnormal long-term depression

[Term]
id: MP:0001482
name: obsolete Increased Pupil Restriction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001483
name: obsolete Decreased Pupil Restriction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001485
name: abnormal pinna reflex
alt_id: MP:0001962
def: "anomaly in the response to an auditory stimulus by a characteristic ear twitch" [PMID:11583390]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal ear twitch response" EXACT []
synonym: "abnormal Preyer's reflex" EXACT []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001486
name: abnormal startle reflex
def: "aberrant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001488
name: increased startle reflex
alt_id: MP:0001487
def: "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased startle response in acoustic startle test" EXACT []
is_a: MP:0001486 ! abnormal startle reflex

[Term]
id: MP:0001489
name: decreased startle reflex
def: "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [https://orcid.org/0000-0003-3691-0324, ISBN:0-471-31639-3]
subset: Europhenome_Terms
subset: IMPC
synonym: "reduced startle reflex" EXACT []
is_a: MP:0001486 ! abnormal startle reflex

[Term]
id: MP:0001490
name: abnormal vibrissae reflex
alt_id: MP:0001276
alt_id: MP:0001969
def: "animals do not change position in response to stimulation of the whiskers" [J:17194]
synonym: "abnormal vibrissa reflex" EXACT []
synonym: "failure to orient in response to vibrissae stimulation" EXACT []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001491
name: unresponsive to tactile stimuli
alt_id: MP:0001971
alt_id: MP:0001976
def: "absence of reflex action normally induced by touch or pain" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "absent pain responsiveness in pin prick test" EXACT []
synonym: "absent pain responsiveness in tail pinch test" EXACT []
synonym: "absent tactile reflex" EXACT []
synonym: "tactile analgesia" RELATED []
is_a: MP:0005316 ! abnormal response to tactile stimuli

[Term]
id: MP:0001492
name: abnormal pilomotor reflex
def: "anomaly in the involuntary bristling of hairs that occurs when an organism is cold or experiences strong emotions such as fear or awe" [https://orcid.org/0000-0003-3691-0324, MESH:F02.830.702.607]
comment: The pilomotor reflex occurs in many mammals; for example, porcupines raise their quills when threatened. Piloerection as a response to cold or fear is vestigial in humans; as humans retain only very little body hair, the reflex (in humans) now provides no known benefit.
synonym: "abnormal piloerection response" EXACT []
synonym: "cutis anserina" RELATED []
synonym: "goosebumps" RELATED []
synonym: "horripilation" RELATED []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001496
name: audiogenic seizures
alt_id: MP:0000949
def: "a reflex seizure triggered by loud noises" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0000947 ! convulsive seizures
is_a: MP:0009358 ! environmentally induced seizures

[Term]
id: MP:0001499
name: abnormal kindling response
def: "any anomaly in the long-lasting epileptogenic changes normally induced by daily sub threshold electrical brain stimulation, often used as an induced model for epilepsy" [ISBN:0-683-40008-8, J:45446]
synonym: "abnormal kindling behavior" EXACT []
synonym: "abnormal kindling behaviour" EXACT []
is_a: MP:0001650 ! abnormal seizure response to electrical stimulation

[Term]
id: MP:0001500
name: decreased kindling response
def: "fewer epileptogenic changes normally induced by daily sub threshold electrical brain stimulation" [J:45446]
synonym: "decreased kindling behavior" EXACT []
synonym: "decreased kindling behaviour" EXACT []
synonym: "reduced kindling behavior" EXACT []
synonym: "reduced kindling behaviour" EXACT []
synonym: "reduced kindling response" EXACT []
is_a: MP:0001499 ! abnormal kindling response

[Term]
id: MP:0001501
name: abnormal sleep pattern
alt_id: MP:0002004
def: "deviation from the normal wake/sleep cycle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011396 ! abnormal sleep behavior

[Term]
id: MP:0001502
name: obsolete abnormal circadian rhythm
def: "deviation from the normal 24 hour biological activity cycle" [https://orcid.org/0000-0003-3691-0324]
comment: 'has part' some \n    (quality\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))\nterm was placed under behavior but definition was for any circadian rhythm not just behavior\nalt ID MP:0002005
is_obsolete: true

[Term]
id: MP:0001503
name: obsolete abnormal strength/ posture
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001504
consider: MP:0004262

[Term]
id: MP:0001504
name: abnormal posture
def: "atypical intentionally or habitually assumed position of the limbs or carriage of the body" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0001505
name: hunched posture
def: "stooped low with the limbs pulled in close to the body and arched back" [J:30404, J:67231]
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0001506
name: limp posture
def: "lack of rigidity of the carriage of the body" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, J:60159]
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0001507
name: obsolete positional passivity
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001508
name: obsolete abnormal body tone
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001509
name: obsolete abnormal body position
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001510
name: abnormal coat appearance
def: "anomaly in the visual aspect of the coat or hair" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal appearance of the fur" EXACT []
is_a: MP:0000367 ! abnormal coat/ hair morphology

[Term]
id: MP:0001511
name: disheveled coat
def: "coat that looks generally unkempt" [MGI:cwg]
synonym: "disheveled appearance of the fur" EXACT []
synonym: "ragged coat" EXACT []
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0001512
name: trunk curl
def: "posture of the trunk in a curled position" [MGI:cml]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0001513
name: limb grasping
def: "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [MGI:cml]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal clutching reflex" EXACT []
synonym: "grasping reflex" EXACT []
synonym: "hind limb extension reflex" EXACT []
synonym: "hindlimb extension reflex" EXACT []
synonym: "limb clamping" EXACT []
synonym: "limb clasping" EXACT []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001514
name: obsolete abnormal footprint pathway
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001515
name: abnormal grip strength
def: "altered ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0004262 ! abnormal physical strength

[Term]
id: MP:0001516
name: abnormal motor coordination/balance
def: "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "impaired proprioception" EXACT []
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0001522
name: impaired swimming
def: "reduced ability or inability to swim" [J:39081, J:45446]
synonym: "impaired ability to orient in water" NARROW []
is_a: MP:0001516 ! abnormal motor coordination/balance
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0001523
name: impaired righting response
def: "reduced ability or greater amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002862 ! abnormal righting response

[Term]
id: MP:0001524
name: impaired limb coordination
def: "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [https://orcid.org/0000-0003-3691-0324, J:17123, J:64962]
is_a: MP:0001405 ! impaired coordination
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0001525
name: impaired balance
def: "reduced ability of an animal to maintain equilibrium" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0001526
name: abnormal placing response
def: "altered ability to stretch and lift the forelimbs and head to grab a close edge" [MGI:cml, PMID:11136708]
synonym: "abnormal reaching response" EXACT []
synonym: "abnormal visual placing" EXACT []
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0001527
name: athetotic walking movements
def: "characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes" [ISBN:0-683-40008-8, PMID:8208292]
synonym: "athetosis" EXACT []
is_a: MP:0001516 ! abnormal motor coordination/balance
is_a: MP:0003312 ! abnormal locomotor coordination
is_a: MP:0003492 ! abnormal involuntary movement

[Term]
id: MP:0001529
name: abnormal vocalization
alt_id: MP:0001528
def: "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [MGI:cml]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0001530
name: obsolete Increased Vocalization
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001529

[Term]
id: MP:0001531
name: obsolete Decreased Vocalization
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001529

[Term]
id: MP:0001532
name: obsolete Physiology
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001533
name: abnormal skeleton physiology
def: "any functional anomaly of the bony framework of the body" [ISBN:0-683-40008-8]
synonym: "abnormal bone/ skeleton physiology" EXACT []
synonym: "bone/ skeletal physiology abnormalities" EXACT []
is_a: MP:0005390 ! skeleton phenotype

[Term]
id: MP:0001539
name: decreased caudal vertebrae number
def: "reduced number of the bony segments of the tail or tail remnant" [ISBN:0-683-40008-8]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of caudal vertebrae" EXACT []
synonym: "decreased number of tail vertebrae" EXACT []
synonym: "reduced caudal vertebrae number" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0004645 ! decreased vertebrae number

[Term]
id: MP:0001541
name: abnormal osteoclast physiology
def: "any functional anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092]
synonym: "abnormal chondroclast physiology" RELATED []
is_a: MP:0002451 ! abnormal macrophage physiology
is_a: MP:0002998 ! abnormal bone remodeling

[Term]
id: MP:0001542
name: abnormal bone strength
def: "change in the ability of bone to endure the application of force without yielding or breaking" [ISBN:0-683-40008-8]
is_a: MP:0001533 ! abnormal skeleton physiology

[Term]
id: MP:0001544
name: abnormal cardiovascular system physiology
alt_id: MP:0000302
alt_id: MP:0001623
alt_id: MP:0001626
alt_id: MP:0002130
def: "any functional anomaly of the heart or vascular tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiovascular function" EXACT []
synonym: "abnormal circulatory system physiology" EXACT []
synonym: "abnormal heart function" NARROW []
synonym: "circulatory system physiology abnormalities" EXACT []
synonym: "heart/cardiovascular system: other functional anomalies" EXACT []
synonym: "other abnormal cardiovascular system physiology" EXACT []
xref: MGI:2173590
is_a: MP:0005385 ! cardiovascular system phenotype

[Term]
id: MP:0001545
name: abnormal hematopoietic system physiology
def: "any functional anomaly of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [ISBN:0-683-40008-8]
synonym: "abnormal haematopoietic system physiology" EXACT []
synonym: "abnormal haemopoietic system physiology" EXACT []
synonym: "abnormal hemopoietic system physiology" EXACT []
synonym: "blood defects" EXACT []
synonym: "blood physiology abnormalities" EXACT []
is_a: MP:0005397 ! hematopoietic system phenotype

[Term]
id: MP:0001547
name: abnormal lipid level
def: "any anomaly in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [ISBN:0-683-40008-8]
synonym: "abnormal lipid storage" NARROW []
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0001548
name: hyperlipidemia
def: "abnormally high concentration of lipids in the circulating blood" [ISBN:0-683-40008-8, PMID:8941642]
synonym: "hyperlipaemia" EXACT []
synonym: "hyperlipemia" EXACT []
synonym: "hyperlipidaemia" EXACT []
synonym: "lipaemia" EXACT []
synonym: "lipemia" EXACT []
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0001552
name: increased circulating triglyceride level
alt_id: MP:0005142
def: "greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated plasma triacylglycerol level" NARROW []
synonym: "elevated plasma triglyceride level" NARROW []
synonym: "elevated serum triacylglycerol level" NARROW []
synonym: "elevated serum triglyceride level" NARROW []
synonym: "hypertriglyceridaemia" EXACT []
synonym: "hypertriglyceridemia" EXACT []
is_a: MP:0005317 ! increased triglyceride level
is_a: MP:0011969 ! abnormal circulating triglyceride level

[Term]
id: MP:0001553
name: abnormal circulating free fatty acids level
def: "any anomaly in the blood concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8]
synonym: "abnormal circulating free fatty acid level" EXACT []
synonym: "abnormal circulating non-esterified fatty acids level" EXACT []
synonym: "abnormal FFA level" BROAD []
synonym: "abnormal NEFA level" BROAD []
synonym: "abnormal UFA level" BROAD []
synonym: "abnormal unesterified fatty acids level" BROAD []
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0010358 ! abnormal free fatty acids level

[Term]
id: MP:0001554
name: increased circulating free fatty acids level
def: "higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated serum free fatty acid levels" NARROW []
synonym: "increased circulating free fatty acid level" EXACT []
synonym: "increased circulating non-esterified fatty acids level" EXACT []
synonym: "increased FFA level" EXACT []
synonym: "increased free fatty acids level" RELATED []
synonym: "increased NEFA level" RELATED []
synonym: "increased UFA level" EXACT []
synonym: "increased unesterified fatty acids level" EXACT []
is_a: MP:0001553 ! abnormal circulating free fatty acids level
is_a: MP:0005281 ! increased fatty acids level

[Term]
id: MP:0001556
name: increased circulating HDL cholesterol level
alt_id: MP:0000185
alt_id: MP:0002617
def: "higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated circulating HDL cholesterol level" EXACT []
synonym: "elevated HDL cholesterol level" BROAD []
synonym: "high HDL cholesterol level" BROAD []
synonym: "high HDL serum level" NARROW []
synonym: "increased HDL cholesterol level" BROAD []
is_a: MP:0000184 ! abnormal circulating HDL cholesterol level
is_a: MP:0005178 ! increased circulating cholesterol level

[Term]
id: MP:0001559
name: hyperglycemia
alt_id: MP:0000190
alt_id: MP:0002612
def: "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "high blood glucose levels" EXACT []
synonym: "hyperglycaemia" EXACT []
synonym: "Increased Blood Glucose Level" EXACT []
is_a: MP:0005559 ! increased circulating glucose level

[Term]
id: MP:0001560
name: abnormal circulating insulin level
alt_id: MP:0000191
def: "any anomaly in the blood concentration of the polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [ISBN:0-683-40008-8]
synonym: "abnormal blood insulin level" EXACT []
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0001562
name: abnormal circulating calcium level
alt_id: MP:0000193
alt_id: MP:0001767
def: "any anomaly in the concentration of calcium in the blood" [MGI:cwg]
synonym: "abnormal blood calcium level" EXACT []
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020879 ! abnormal calcium level

[Term]
id: MP:0001565
name: abnormal circulating phosphate level
alt_id: MP:0000196
alt_id: MP:0001772
def: "any anomaly in the blood concentrations of the salt or ester of phosphoric acid" [ISBN:0-683-40008-8]
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020885 ! abnormal phosphate level

[Term]
id: MP:0001566
name: increased circulating phosphate level
alt_id: MP:0000197
alt_id: MP:0001773
def: "abnormally high concentrations of phosphates in the circulating blood" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "hyperphosphataemia" EXACT []
synonym: "hyperphosphatemia" EXACT []
is_a: MP:0001565 ! abnormal circulating phosphate level
is_a: MP:0014545 ! increased phosphate level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0001569
name: abnormal circulating bilirubin level
alt_id: MP:0000200
def: "any anomaly in the concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0001570
name: abnormal circulating enzyme level
alt_id: MP:0000201
def: "aberrant concentration in the blood of any of the proteins that act as catalysts for biological reactions" [MGI:cwg]
synonym: "abnormal blood enzyme level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
is_a: MP:0005416 ! abnormal circulating protein level

[Term]
id: MP:0001573
name: abnormal circulating alanine transaminase level
alt_id: MP:0000204
def: "aberrant concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [ISBN:0-683-40008-8]
synonym: "abnormal alanine aminotransferase level" BROAD []
synonym: "abnormal alanine transaminase level" BROAD []
synonym: "abnormal ALT level" BROAD []
synonym: "abnormal GPT level" BROAD []
synonym: "abnormal serum glutamate pyruvate transaminase level" NARROW []
synonym: "abnormal serum glutamic-pyruvic transaminase level" NARROW []
synonym: "abnormal SGPT level" NARROW []
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0001574
name: abnormal oxygen level
def: "any anomaly in the concentration of the gaseous element that is essential for animal and plant life" [ISBN:0-683-40008-8]
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0001575
name: cyanosis
def: "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "cyanotic" EXACT []
is_a: MP:0001574 ! abnormal oxygen level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0001577
name: anemia
def: "less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs" [ISBN:0-683-40008-8, PMID:9949198]
synonym: "anaemia" EXACT []
is_a: MP:0002429 ! abnormal blood cell morphology/development

[Term]
id: MP:0001584
name: obsolete platelet storage pool deficiency
alt_id: MP:0000212
def: "OBSOLETE. a blood coagulation disorder in which there is a decrease or lack of platelet dense bodies" [MESH:C15.378.100.685]
comment: This is really a disease term; see OMIM:185050.
synonym: "platelet storage pooling deficiency" EXACT []
is_obsolete: true
consider: MP:0004721

[Term]
id: MP:0001585
name: hemolytic anemia
alt_id: MP:0000213
def: "deficiency of red cells resulting from an increased rate of erythrocyte destruction" [ISBN:0-683-40008-8]
synonym: "haemolytic anaemia" EXACT []
synonym: "hemolytic anaemia" EXACT []
synonym: "increased rate of erythrocyte destruction" EXACT []
is_a: MP:0001577 ! anemia

[Term]
id: MP:0001586
name: abnormal erythrocyte cell number
alt_id: MP:0000214
def: "altered number of the cells that transport oxygen, red blood cells, per unit" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal definitive erythrocyte cell number" EXACT []
synonym: "abnormal erythrocyte count" EXACT []
synonym: "abnormal RBC count" EXACT []
synonym: "abnormal red blood cell count" EXACT []
synonym: "erythrocyte count abnormalities" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
is_a: MP:0013661 ! abnormal myeloid cell number

[Term]
id: MP:0001588
name: abnormal hemoglobin
alt_id: MP:0000224
def: "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [ISBN:0-683-40008-8]
synonym: "abnormal haemoglobin" EXACT []
synonym: "haemoglobin abnormalities" EXACT []
synonym: "haemoglobin defects" EXACT []
synonym: "hemoglobin abnormalities" EXACT []
synonym: "hemoglobin defects" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0001589
name: abnormal mean corpuscular hemoglobin
alt_id: MP:0000225
alt_id: MP:0002595
def: "anomalies in the average levels of hemoglobin contained in an erythrocyte" [ISBN:0-683-40008-8]
comment: Mean corpuscular hemoglobin (MCH) is a standard measurment in clinical chemistry, usually reported in picograms/cell.
synonym: "abnormal MCH" EXACT []
synonym: "abnormal mean corpuscular haemoglobin" EXACT []
synonym: "mean corpuscular haemoglobin" EXACT []
synonym: "mean corpuscular hemoglobin" EXACT []
is_a: MP:0001588 ! abnormal hemoglobin

[Term]
id: MP:0001596
name: hypotension
alt_id: MP:0000232
def: "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [ISBN:0-683-40008-8]
is_a: MP:0002843 ! decreased systemic arterial blood pressure

[Term]
id: MP:0001598
name: abnormal blood viscosity
alt_id: MP:0000234
def: "anomaly in the resistance to flow of the blood through the vessels" [ISBN:0-683-40008-8]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0001599
name: abnormal blood volume
alt_id: MP:0000235
def: "any anomaly in the amount of space occupied by the blood in the vessels" [ISBN:0-683-40008-8]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0001601
name: abnormal myelopoiesis
alt_id: MP:0000169
def: "anomaly in the process of, or atypical formation of myeloid cells from the pluripotent hematopoietic stem cells in the bone marrow from myeloid stem cells, including the production of leukocytes in blood, such as monocytes and granulocytes and precursor cells for macrophage and dendritic cells found in the lymphoid tissue" [MESH:G04.335.151.825.597.750]
synonym: "abnormal myeloid cell differentiation" EXACT []
synonym: "myelopoiesis abnormalities" EXACT []
is_a: MP:0005460 ! abnormal leukopoiesis

[Term]
id: MP:0001602
name: impaired myelopoiesis
alt_id: MP:0000170
def: "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [ISBN:0-683-40008-8, MGI:tc]
synonym: "reduced myelopoiesis" EXACT []
is_a: MP:0001601 ! abnormal myelopoiesis

[Term]
id: MP:0001603
name: failure of myelopoiesis
alt_id: MP:0000171
def: "missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells" [ISBN:0-683-40008-8, MGI:tc, PMID:10716451]
synonym: "absence of myelopoiesis" EXACT []
is_a: MP:0001601 ! abnormal myelopoiesis

[Term]
id: MP:0001606
name: impaired hematopoiesis
alt_id: MP:0000244
alt_id: MP:0001607
def: "atypical process of blood cell formation with the result of fewer of these cells being formed" [MGI:tc, PMID:10716451]
synonym: "impaired haematopoiesis" EXACT []
synonym: "reduced haematogenesis" EXACT []
synonym: "reduced haematopoiesis" EXACT []
synonym: "reduced haematosis" EXACT []
synonym: "reduced haemogenesis" EXACT []
synonym: "reduced haemopoiesis" EXACT []
synonym: "reduced hematogenesis" EXACT []
synonym: "reduced hematopoiesis" EXACT []
synonym: "reduced hematosis" EXACT []
synonym: "reduced hemogenesis" EXACT []
synonym: "reduced hemopoiesis" EXACT []
synonym: "reduced sanguification" EXACT []
is_a: MP:0002429 ! abnormal blood cell morphology/development

[Term]
id: MP:0001613
name: abnormal vasodilation
alt_id: MP:0000251
alt_id: MP:0005594
def: "anomaly in the physiological widening of the lumen of the blood vessels by relaxing the underlying vascular smooth muscle" [ISBN:0-683-40008-8, MESH:G09.330.582.400.925]
synonym: "abnormal vascular endothelium-dependent relaxation" EXACT []
synonym: "abnormal vascular relaxation" EXACT []
synonym: "abnormal vascular smooth muscle dilation" EXACT []
synonym: "abnormal vasodilatation" EXACT []
synonym: "abnormal vasorelaxation" EXACT []
is_a: MP:0005595 ! abnormal vascular smooth muscle physiology

[Term]
id: MP:0001614
name: abnormal blood vessel morphology
alt_id: MP:0000252
alt_id: MP:0001611
alt_id: MP:0002125
def: "any structural anomaly of the network of tubes that carries blood through the body" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal blood vasculature morphology" EXACT []
synonym: "blood vessel abnormalities" BROAD []
synonym: "blood vessel dysplasia" NARROW []
synonym: "vascular dysplasia" NARROW []
synonym: "vasculature abnormalities" BROAD []
is_a: MP:0002127 ! abnormal cardiovascular system morphology

[Term]
id: MP:0001615
name: obsolete Decreased Vasculature
alt_id: MP:0000253
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "Decreased Vasculature" EXACT []
is_obsolete: true
consider: MP:0001614

[Term]
id: MP:0001616
name: obsolete Increased Vasculature
alt_id: MP:0000254
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001614

[Term]
id: MP:0001619
name: abnormal vascular permeability
alt_id: MP:0000258
def: "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [ISBN:0-683-40008-8]
is_a: MP:0000249 ! abnormal blood vessel physiology

[Term]
id: MP:0001622
name: abnormal vasculogenesis
alt_id: MP:0000261
def: "aberrant process of the initial establishment of the vascular network" [https://orcid.org/0000-0003-3691-0324]
synonym: "vasculogenesis abnormalities" EXACT []
is_a: MP:0000259 ! abnormal vascular development

[Term]
id: MP:0001625
name: cardiac hypertrophy
def: "an increase in size of the cardiac tissue, not due to increased cell number" [ISBN:0-683-40008-8]
is_a: MP:0000274 ! enlarged heart

[Term]
id: MP:0001627
name: abnormal cardiac output
alt_id: MP:0000303
def: "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [MESH:E01.370.370.380.150, MGI:cwg]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0001629
name: abnormal heart rate
alt_id: MP:0000305
def: "greater than or fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute" [https://orcid.org/0000-0002-0371-1954, MESH:G09.330.553.660.500]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0004085 ! abnormal heartbeat

[Term]
id: MP:0001633
name: poor circulation
def: "insufficient movement of blood throughout the body, often manifesting in cold and/or pale skin" [https://orcid.org/0000-0003-3691-0324, PMID:9362461]
synonym: "cold skin" RELATED []
synonym: "pale skin" RELATED []
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0001634
name: internal hemorrhage
def: "blood loss in the interior of the body due to vessel rupture or dysmorphology" [PMID:7854452]
synonym: "internal bleeding" EXACT []
synonym: "internal haemorrhage" EXACT []
is_a: MP:0001914 ! hemorrhage

[Term]
id: MP:0001636
name: irregular heartbeat
def: "uneven timing of heart contraction" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "altered heart rhythm" EXACT []
synonym: "arrhythmia" BROAD []
is_a: MP:0004085 ! abnormal heartbeat

[Term]
id: MP:0001637
name: obsolete cardiac arrest
def: "OBSOLETE. complete cessation of cardiac activity" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001641
name: obsolete death
def: "OBSOLETE. cessation of life; cessation of integrated tissue and organ functions; a gradual process at the cellular level" [ISBN:0-683-40008-8]
is_obsolete: true
consider: MP:0001657
consider: MP:0010769

[Term]
id: MP:0001648
name: abnormal apoptosis
def: "excessive or absent cell death in a particular tissue or cell type" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
xref: GO:0006915
is_a: MP:0014355 ! abnormal programmed cell death

[Term]
id: MP:0001649
name: abnormal mandibular symphysis morphology
alt_id: MP:0000096
def: "any structural anomaly of the fibrocartilagenous union of the two halves of the mandible (embryonic stages)" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "abnormal inter-mandibular joint morphology" EXACT []
synonym: "abnormal intermandibular joint morphology" EXACT []
synonym: "abnormal mental symphysis morphology" RELATED []
synonym: "abnormal symphysis mandibulae morphology" RELATED []
synonym: "abnormal symphysis mentalis morphology" RELATED []
synonym: "abnormal symphysis menti morphology" EXACT []
synonym: "symphysis menti dysplasia" NARROW []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030877 ! abnormal symphysis morphology

[Term]
id: MP:0001650
name: abnormal seizure response to electrical stimulation
def: "anomaly in the seizure activity response that is brought about by high or low frequency electrical stimulation" [https://orcid.org/0000-0003-3691-0324, MGI:wf]
synonym: "electrically induced seizures" RELATED []
is_a: MP:0009357 ! abnormal seizure response to inducing agent

[Term]
id: MP:0001651
name: obsolete necrosis
def: "pathological death of cells or a portion of a tissue or organ; usually due to irreversible damage" [PMID:7830794]
comment: This term is nonspecific.  Use MP:0000316 for widespread cellular necrosis, or use tissue-specific terms.
is_obsolete: true
replaced_by: MP:0000316

[Term]
id: MP:0001652
name: colonic necrosis
def: "morphological changes resulting from pathological death of some or all colon tissue; usually due to irreversible damage" [MGI:cwg]
synonym: "necrotic colon" EXACT []
is_a: MP:0000495 ! abnormal colon morphology

[Term]
id: MP:0001653
name: gastric necrosis
def: "morphological changes resulting from pathological death of gastric tissue; usually due to irreversible damage" [MGI:cwg]
synonym: "necrotic stomach" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0001654
name: hepatic necrosis
def: "morphological changes resulting from pathological death of liver tissue; usually due to irreversible damage" [MGI:cwg]
synonym: "liver necrosis" EXACT []
synonym: "necrotic liver" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0001655
name: multifocal hepatic necrosis
def: "morphological changes resulting from multiple localized areas of pathological death of liver tissue; usually due to irreversible damage" [MGI:cwg]
synonym: "multifocal liver necrosis" EXACT []
synonym: "multifocally necrotic liver" EXACT []
is_a: MP:0001654 ! hepatic necrosis

[Term]
id: MP:0001656
name: focal hepatic necrosis
def: "morphological changes resulting from one or more localized areas of pathological death of some or all liver tissue; usually due to irreversible damage" [MGI:cwg]
synonym: "focal liver necrosis" EXACT []
synonym: "focally necrotic liver" EXACT []
is_a: MP:0001654 ! hepatic necrosis

[Term]
id: MP:0001657
name: abnormal induced morbidity/mortality
def: "differences from the expected diseased state or death caused by an external intervention" [MGI:cwg]
is_a: MP:0010768 ! mortality/aging

[Term]
id: MP:0001658
name: increased mortality induced by gamma-irradiation
def: "greater sensitivity to doses of ionizing radiation" [J:51834]
is_a: MP:0003992 ! increased mortality induced by ionizing radiation

[Term]
id: MP:0001659
name: obsolete altered life span
alt_id: MP:0001660
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "altered life span" EXACT []
is_obsolete: true
consider: MP:0010769

[Term]
id: MP:0001661
name: extended life span
def: "persistence of life for a longer period than is normal for an organism" [MGI:cwg]
synonym: "extended lifespan" EXACT []
is_a: MP:0010769 ! abnormal survival

[Term]
id: MP:0001663
name: abnormal digestive system physiology
alt_id: MP:0002142
def: "any functional anomaly of the organ system that converts ingested food to nutrients and energy" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "digestive system physiology abnormalities" EXACT []
synonym: "digestive system: functional anomalies" EXACT []
xref: MGI:2173602
is_a: MP:0005381 ! digestive/alimentary phenotype

[Term]
id: MP:0001664
name: abnormal digestion
def: "any anomaly of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism" [GO:0007586]
synonym: "abnormal digestive function" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology

[Term]
id: MP:0001665
name: chronic diarrhea
def: "prolonged diarrhea" [ISBN:0-683-40008-8]
synonym: "chronic diarrhoea" EXACT []
synonym: "prolonged diarrhoea" EXACT []
is_a: MP:0005036 ! diarrhea

[Term]
id: MP:0001666
name: abnormal intestinal absorption
alt_id: MP:0008865
def: "any anomaly in the quantity or rate of any nutrient taken up from the contents of the intestine" [GO:0050892]
synonym: "abnormal nutrient absorption" EXACT []
is_a: MP:0001664 ! abnormal digestion

[Term]
id: MP:0001667
name: obsolete abnormal carbohydrate absorption
def: "any anomaly in the ability of the body to take in substances composed of carbon, hydrogen, and oxygen according to the general formula Cn(H2O)n; sugars and starches are examples" [MGI:cwg]
comment: Carbohydrates are not absorbed in the intestines; they must be converted to monosaccharides in the digestive process before uptake by the intestines.
is_obsolete: true
replaced_by: MP:0001669

[Term]
id: MP:0001668
name: abnormal intestinal fructose absorption
def: "any anomaly in the ability of the small intestine to absorb fructose into the bloodstream" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal fructose absorption" BROAD []
is_a: MP:0001666 ! abnormal intestinal absorption

[Term]
id: MP:0001669
name: abnormal intestinal glucose absorption
def: "any anomaly in the ability of the small intestine to absorb glucose into the bloodstream" [GO:0001951, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glucose absorption" BROAD []
synonym: "abnormal intestinal D-glucose absorption" EXACT []
is_a: MP:0001666 ! abnormal intestinal absorption

[Term]
id: MP:0001670
name: abnormal intestinal mineral absorption
def: "any anomaly in the ability of the body to take up inorganic substances that have importance in body functions into the blood by absorption from the small intestine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001666 ! abnormal intestinal absorption

[Term]
id: MP:0001671
name: abnormal vitamin absorption
def: "any anomaly in the ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [ISBN:0-683-40008-8]
is_a: MP:0001666 ! abnormal intestinal absorption
is_a: MP:0004019 ! abnormal vitamin homeostasis

[Term]
id: MP:0001672
name: abnormal embryo development
def: "anomaly in the establishment of the characteristic configuration of the embryonic body" [ISBN:0-683-40008-8]
synonym: "abnormal embryogenesis/ development" EXACT []
synonym: "embryogenesis/ development abnormalities" EXACT []
xref: GO:0007275
is_a: MP:0005380 ! embryo phenotype

[Term]
id: MP:0001674
name: abnormal germ layer development
def: "abnormal development of the three primary germ layers of the embryo" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal triploblastic development" EXACT []
is_a: MP:0001695 ! abnormal gastrulation

[Term]
id: MP:0001675
name: abnormal ectoderm development
def: "any abnormality in the formation of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation; ectoderm is in contact with the amnionic cavity and gives rise to two distinct lineages, i.e. the surface ectoderm and the neural ectoderm; it is the source of Rathke's pouch and forms the central and peripheral nervous systems, the sensory epithelia of the eye, ear, and nose, the epidermis and its appendages (nails and hair), the mammary, pituitary and subcutaneous glands, the tooth enamel, and the mucous membranes of the mouth and anus" [http://discovery.lifemapsc.com/in-vivo-development/ectoderm, http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-25-germ-layers-and-their-derivatives, http://en.wikipedia.org/wiki/Ectoderm, https://orcid.org/0000-0002-6490-7723]
xref: GO:0001705
is_a: MP:0001674 ! abnormal germ layer development

[Term]
id: MP:0001676
name: abnormal apical ectodermal ridge morphology
def: "any structural anomaly of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
synonym: "abnormal AER" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology
is_a: MP:0014139 ! abnormal ectoderm morphology

[Term]
id: MP:0001677
name: absent apical ectodermal ridge
def: "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [PMID:10227294]
synonym: "absence of apical ectodermal ridge" EXACT []
synonym: "absent AER" EXACT []
is_a: MP:0001676 ! abnormal apical ectodermal ridge morphology

[Term]
id: MP:0001678
name: thick apical ectodermal ridge
def: "increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
synonym: "thick AER" EXACT []
is_a: MP:0001676 ! abnormal apical ectodermal ridge morphology

[Term]
id: MP:0001679
name: thin apical ectodermal ridge
def: "decrease in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
synonym: "thin AER" EXACT []
is_a: MP:0001676 ! abnormal apical ectodermal ridge morphology

[Term]
id: MP:0001680
name: abnormal mesoderm development
alt_id: MP:0001681
def: "failure or abnormality in the formation of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mesoderm differentiation" EXACT []
xref: GO:0001707
is_a: MP:0001674 ! abnormal germ layer development

[Term]
id: MP:0001683
name: absent mesoderm
alt_id: MP:0001682
def: "absence of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "absence of mesoderm" EXACT []
synonym: "Failure of Mesoderm Formation" EXACT []
xref: GO:0001707
is_a: MP:0014141 ! abnormal mesoderm morphology

[Term]
id: MP:0001684
name: abnormal axial mesoderm morphology
def: "failure or abnormality in the formation of part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014141 ! abnormal mesoderm morphology

[Term]
id: MP:0001685
name: abnormal endoderm development
alt_id: MP:0001686
def: "any abnormality in the formation of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) during gastrulation; endoderm gives rise to the epithelial lining of the gastrointestinal and respiratory tracts; the parenchyma of the tonsils, the liver, the thymus, the thyroid, the parathyroids, and the pancreas; the epithelial lining of the urinary bladder, urethra, and prostate; and the epithelial lining of the tympanic cavity, tympanic antrum, and auditory tube" [http://discovery.lifemapsc.com/in-vivo-development/endoderm, http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-25-germ-layers-and-their-derivatives, http://education-portal.com/academy/lesson/endoderm-layer-definition-derivatives-quiz.html#lesson]
synonym: "abnormal definitive endoderm development" EXACT []
synonym: "abnormal endoderm differentiation" EXACT []
synonym: "abnormal entoderm development" EXACT []
xref: GO:0001706
is_a: MP:0001674 ! abnormal germ layer development

[Term]
id: MP:0001687
name: thin endoderm
def: "reduced thickness of the innermost germ layer of the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "thin definitive endoderm" EXACT []
synonym: "thin entoderm" EXACT []
is_a: MP:0014140 ! abnormal endoderm morphology

[Term]
id: MP:0001688
name: abnormal somite development
def: "any anomaly in the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo; somites are transient structures - balls or blocks of paraxial mesoderm cells with an epithelial outer layer and a mesenchymal cell core - that emerge sequentially through a mesenchymal-to-epithelial transition (MET) from the morphologically unpatterned presomitic mesoderm; they give rise to the metameric anatomy of the vertebral column itself, and the associated skin, muscle and tendons" [GO:0001756, PMID:21164524]
subset: IMPC_Prenatal
synonym: "abnormal metablastic segment development" EXACT []
synonym: "abnormal somite formation" EXACT []
synonym: "abnormal somite segmentation" EXACT []
synonym: "abnormal somitogenesis" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0001689
name: incomplete somite formation
def: "arrest of differentiation or patterning of the somites" [J:62882]
is_a: MP:0009768 ! impaired somite development

[Term]
id: MP:0001690
name: failure of somite differentiation
def: "disorganized or absent somite tissue or somite pattern in development" [J:25248]
is_a: MP:0009768 ! impaired somite development

[Term]
id: MP:0001691
name: abnormal somite shape
def: "anomaly in the characteristic surface outline or contour of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo" [https://orcid.org/0000-0003-3691-0324]
synonym: "irregular somite shape" EXACT []
is_a: MP:0001688 ! abnormal somite development

[Term]
id: MP:0001693
name: failure of primitive streak formation
def: "inability to form the epiblast ridge from which arises the germ layers of the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
xref: GO:0007369
is_a: MP:0002230 ! abnormal primitive streak formation

[Term]
id: MP:0001694
name: absent egg cylinders
def: "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
synonym: "failure to form egg cylinders" EXACT []
is_a: MP:0003085 ! abnormal egg cylinder morphology

[Term]
id: MP:0001695
name: abnormal gastrulation
def: "any anomaly in the development and invagination of the embryonic germ layers" [ISBN:0-683-40008-8]
comment: in the mouse, gastrulation initiates at E6.5, as cells of the primitive ectoderm (epiblast) delaminate at the posterior side of the embryo and ingress through the primitive streak in an epithelial-to-mesenchymal transition
xref: GO:0007669
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0001696
name: failure to gastrulate
def: "inability to differentiate and invaginate the primary germ layers" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
xref: GO:0007669
is_a: MP:0001695 ! abnormal gastrulation

[Term]
id: MP:0001697
name: abnormal embryo size
def: "any anomaly in the proportions of embryo compared to littermates (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:cwg]
is_a: MP:0002088 ! abnormal embryonic growth/weight/body size
is_a: MP:0010866 ! abnormal prenatal body size
is_a: MP:0014134 ! abnormal embryo morphology

[Term]
id: MP:0001698
name: decreased embryo size
def: "smaller proportions of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:cwg]
subset: IMPC_Prenatal
synonym: "reduced embryo size" EXACT []
synonym: "small embryo" EXACT []
is_a: MP:0001697 ! abnormal embryo size

[Term]
id: MP:0001699
name: increased embryo size
def: "larger proportions of embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:cwg]
subset: IMPC_Prenatal
synonym: "enlarged embryo size" EXACT []
is_a: MP:0001697 ! abnormal embryo size

[Term]
id: MP:0001700
name: abnormal embryo turning
def: "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage during which the curvature of the entire trunk region is normally reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
comment: In mouse, this event occurs at E8.5-E9.5.
subset: IMPC_Prenatal
synonym: "abnormal embryonic axial rotation" EXACT []
synonym: "Abnormal Turning of Embryo" EXACT []
xref: GO:0007669
is_a: MP:0001695 ! abnormal gastrulation

[Term]
id: MP:0001701
name: incomplete embryo turning
def: "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage" [J:62571]
comment: In mouse, this event occurs at E8.5-E9.5.
subset: IMPC_Prenatal
xref: GO:0007669
is_a: MP:0001700 ! abnormal embryo turning

[Term]
id: MP:0001704
name: abnormal dorsal-ventral axis patterning
def: "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal back-front patterning" EXACT []
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0001705
name: abnormal proximal-distal axis patterning
def: "anomaly in the formation or development of a body structure, often a limb, in relation to the structure's proximity to the trunk or point of origin" [MGI:cwg]
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0001706
name: abnormal left-right axis patterning
def: "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [MGI:cwg]
subset: IMPC_Prenatal
synonym: "abnormal dextro-sinistral axis patterning" EXACT []
synonym: "abnormal L-R axis patterning" EXACT []
synonym: "abnormal sinistro-dextral axis patterning" EXACT []
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0001710
name: absent amniotic folds
def: "failure of the amnion to form involutions" [MGI:cwg]
synonym: "absence of amniotic folds" EXACT []
is_a: MP:0005029 ! abnormal amnion morphology

[Term]
id: MP:0001711
name: abnormal placenta morphology
def: "any structural anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal placental morphology" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0001712
name: abnormal placenta development
def: "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal placental development" EXACT []
is_a: MP:0010038 ! abnormal placenta physiology

[Term]
id: MP:0001713
name: decreased trophoblast giant cell number
def: "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "reduced trophoblast giant cell number" EXACT []
is_a: MP:0005033 ! abnormal trophoblast giant cell morphology

[Term]
id: MP:0001714
name: absent trophoblast giant cells
def: "missing cells of the extraembryonic cell layer that contribute to the placenta" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absence of trophoblast cells" EXACT []
is_a: MP:0001713 ! decreased trophoblast giant cell number

[Term]
id: MP:0001715
name: placental labyrinth hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the placental labyrinth, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplasia of labyrinth" EXACT []
synonym: "hypoplastic labyrinth" EXACT []
synonym: "hypoplastic placental labyrinth" EXACT []
is_a: MP:0011521 ! decreased placental labyrinth size

[Term]
id: MP:0001716
name: abnormal placenta labyrinth morphology
def: "any structural anomaly of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood, and is the site where the exchange of nutrients and waste products occurs between the maternal and fetal circulation" [PMID:10888863]
synonym: "abnormal labyrinth layer morphology" RELATED []
synonym: "abnormal placenta labyrinthine zone morphology" EXACT []
synonym: "abnormal placental labyrinth morphology" EXACT []
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0001717
name: absent ectoplacental cone
def: "missing the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta" [MGI:cwg]
synonym: "absence of ectoplacental cone" EXACT []
synonym: "absent epamniotic cone" EXACT []
is_a: MP:0005032 ! abnormal ectoplacental cone morphology

[Term]
id: MP:0001718
name: abnormal visceral yolk sac morphology
def: "any structural anomaly of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" [ISBN10:9780123364258, ISBN:0-683-40008-8, PMID:21123814]
subset: IMPC_Prenatal
synonym: "abnormal secondary yolk sac morphology" EXACT []
synonym: "abnormal umbilical vesicle morphology" EXACT []
synonym: "abnormal vitelline sac morphology" EXACT []
synonym: "abnormal yolk sac morphology" BROAD []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0001719
name: absent vitelline blood vessels
def: "absence of the vascular network that supplies the yolk sac" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absence of vitelline blood vessels" EXACT []
synonym: "absent omphalomesenteric vessels" NARROW []
is_a: MP:0003229 ! abnormal vitelline vasculature morphology

[Term]
id: MP:0001720
name: obsolete excessive surface folding
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001721
name: absent visceral yolk sac blood islands
def: "absence of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
synonym: "absence of blood islands" EXACT []
synonym: "absent blood islands" EXACT []
is_a: MP:0011204 ! abnormal visceral yolk sac blood island morphology

[Term]
id: MP:0001722
name: pale yolk sac
def: "bloodless yolk sac" [J:62571]
subset: IMPC_Prenatal
is_a: MP:0001718 ! abnormal visceral yolk sac morphology

[Term]
id: MP:0001723
name: disorganized yolk sac vascular plexus
def: "derangement in the pattern of the primary (honeycomb-like) vasculature of the yolk sac prior to remodeling into a mature vascular network" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised yolk sac vascular plexus" EXACT []
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
is_a: MP:0003229 ! abnormal vitelline vasculature morphology

[Term]
id: MP:0001724
name: abnormal extraembryonic endoderm formation
def: "malformation of the derivative of the hypoblast cells that migrate into the blastocyst cavity, and line the cavity, giving rise to the primary and definitive yolk sacs; the extraembryonic endoderm fills the remaining cavity of the blastocyst" [http://discovery.lifemapsc.com/in-vivo-development/hypoblast/extraembryonic-endoderm]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology

[Term]
id: MP:0001725
name: abnormal umbilical cord morphology
def: "any structural anomaly of the connective stalk between the fetus and the placenta" [ISBN:0-683-40008-8, PMID:9144284]
synonym: "abnormal chorda umbilicalis morphology" EXACT []
synonym: "abnormal funiculus umbilicalis morphology" EXACT []
synonym: "umbilical cord dysplasia" NARROW []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0001726
name: abnormal allantois morphology
def: "any structural anomaly fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0001727
name: abnormal embryo implantation
def: "anomaly in the process in which the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development" [ISBN:0-683-40008-8, MGI:llw2, PMID:10882512]
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0001728
name: failure of embryo implantation
def: "inability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development" [PMID:10882512]
synonym: "failure of implantation" EXACT []
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0001729
name: impaired embryo implantation
def: "impaired ability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development" [ISBN:0-683-40008-8, PMID:10882512]
synonym: "abnormal blastocyst activation" RELATED []
synonym: "abnormal blastocyst competency" RELATED []
synonym: "defective implantation" EXACT []
synonym: "impaired implantation" EXACT []
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0001730
name: embryonic growth arrest
def: "the cessation of development beyond a particular stage" [J:17509]
synonym: "arrested embryonic development" EXACT []
is_a: MP:0001672 ! abnormal embryo development

[Term]
id: MP:0001731
name: abnormal postnatal growth
def: "anomaly in reaching a developmental stage or stages after birth" [MGI:il]
synonym: "abnormal growth after birth" EXACT []
is_a: MP:0002089 ! abnormal postnatal growth/weight/body size

[Term]
id: MP:0001732
name: postnatal growth retardation
def: "slow or limited development after birth" [ISBN:0-683-40008-8]
synonym: "atelia" NARROW []
synonym: "ateliosis" NARROW []
synonym: "decreased growth rate" EXACT []
synonym: "reduced growth rate" EXACT []
synonym: "retarded growth after birth" EXACT []
synonym: "stunted growth" EXACT []
is_a: MP:0001731 ! abnormal postnatal growth

[Term]
id: MP:0001734
name: obsolete abnormal endocrine organ
def: "OBSOLETE. any structural anomaly of any of the glands that have no ducts, their secretions being absorbed directly into the blood" [ISBN:0-683-40008-8]
is_obsolete: true
consider: MP:0002163
consider: MP:0002164

[Term]
id: MP:0001739
name: abnormal adrenal gland secretion
def: "altered ability of the surparenal gland to produce or secrete hormones" [MGI:hdene]
synonym: "abnormal adrenal secretion" RELATED []
is_a: MP:0002909 ! abnormal adrenal gland physiology

[Term]
id: MP:0001740
name: failure of adrenal epinephrine secretion
def: "inability of adrenal gland to deliver epinephrine into the blood stream" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10357937]
synonym: "failure of adrenaline secretion" EXACT []
synonym: "failure of epinephrine secretion" EXACT []
is_a: MP:0001739 ! abnormal adrenal gland secretion

[Term]
id: MP:0001741
name: obsolete decreased adrenaline synthesis
def: "OBSOLETE. less than the normal formation of this catecholamine hormone that stimulates the adrenergic receptors" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "decreased epinephrine synthesis" EXACT []
synonym: "reduced adrenaline synthesis" EXACT []
synonym: "reduced epinephrine synthesis" EXACT []
is_obsolete: true

[Term]
id: MP:0001742
name: absent circulating adrenaline
def: "absence in the circulation of a catecholamine hormone that stimulates the adrenergic receptors and causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [ISBN:0-683-40008-8]
synonym: "absence of circulating adrenaline" EXACT []
synonym: "absence of epinephrine" EXACT []
is_a: MP:0005660 ! abnormal circulating adrenaline level

[Term]
id: MP:0001743
name: absent circulating noradrenaline
def: "absence of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [ISBN:0198506732]
synonym: "absence of noradrenaline" EXACT []
synonym: "absence of norepinephrine" EXACT []
is_a: MP:0005663 ! abnormal circulating noradrenaline level

[Term]
id: MP:0001744
name: hypersecretion of corticosterone
def: "increased release of this adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0001739 ! abnormal adrenal gland secretion

[Term]
id: MP:0001745
name: increased circulating corticosterone level
def: "greater than the normal blood amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10357937]
synonym: "elevated serum levels of corticosterone" NARROW []
synonym: "hypercorticosteronaemia" EXACT []
synonym: "hypercorticosteronemia" EXACT []
is_a: MP:0003367 ! increased circulating glucocorticoid level
is_a: MP:0005345 ! abnormal circulating corticosterone level

[Term]
id: MP:0001746
name: abnormal pituitary secretion
def: "anomaly in the production and/or release of biologically active substances from pituitary tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005646 ! abnormal pituitary gland physiology

[Term]
id: MP:0001747
name: hypersecretion of adrenocorticotropin
def: "increased release of this pituitary hormone from the pituitary gland that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypersecretion of ACTH" EXACT []
is_a: MP:0003347 ! hyperpituitarism

[Term]
id: MP:0001748
name: increased circulating adrenocorticotropin level
def: "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, PMID:10357937]
synonym: "elevated serum levels of ACTH" NARROW []
synonym: "increased serum levels of ACTH" NARROW []
synonym: "increased serum levels of adrenocorticotropic hormone" NARROW []
synonym: "increased serum levels of adrenocorticotropin" NARROW []
synonym: "increased serum levels of adrenotropic hormone" NARROW []
synonym: "increased serum levels of adrenotropin" NARROW []
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005129 ! increased adrenocorticotropin level

[Term]
id: MP:0001749
name: suppressed circulating follicle stimulating hormone level
def: "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8]
synonym: "suppressed follicle stimulating hormone levels" EXACT []
synonym: "suppressed FSH levels" EXACT []
is_a: MP:0002790 ! decreased circulating follicle stimulating hormone level

[Term]
id: MP:0001750
name: increased circulating follicle stimulating hormone level
def: "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8, J:35782]
synonym: "increased serum levels of follicle stimulating hormone" NARROW []
synonym: "increased serum levels of follitropin" NARROW []
synonym: "increased serum levels of FSH" NARROW []
synonym: "increased serum levels of gametokinetic hormone" NARROW []
is_a: MP:0003362 ! increased circulating gonadotropin level
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005131 ! increased follicle stimulating hormone level

[Term]
id: MP:0001751
name: increased circulating luteinizing hormone level
def: "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [MESH:D06.472.699.322.576.463]
synonym: "increased circulating luteinising hormone level" EXACT []
synonym: "increased serum levels of LH" NARROW []
synonym: "increased serum levels of luteinising hormone" NARROW []
synonym: "increased serum levels of luteinizing hormone" NARROW []
synonym: "increased serum levels of lutropin" NARROW []
is_a: MP:0003362 ! increased circulating gonadotropin level
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005133 ! increased luteinizing hormone level

[Term]
id: MP:0001752
name: abnormal hypothalamus secretion
def: "altered ability of the hypothalamus to produce or release biologically active substances" [MGI:cwg]
is_a: MP:0005645 ! abnormal hypothalamus physiology

[Term]
id: MP:0001753
name: hypersecretion of corticotropin-releasing hormone
def: "excessive release of this factor, which normally stimulates the pituitary to release adrenocorticotropic hormone, from the hypothalamus" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "hypersecretion of CRH" EXACT []
is_a: MP:0001752 ! abnormal hypothalamus secretion

[Term]
id: MP:0001754
name: increased circulating corticotropin-releasing hormone level
def: "higher than average amount of CRH in blood; CRH is normally released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland" [PMID:10471508]
synonym: "elevated serum levels of corticotropin-releasing hormone" NARROW []
synonym: "elevated serum levels of CRH" NARROW []
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0001755
name: obsolete abnormal excretion physiology
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "excretion defects" EXACT []
synonym: "excretion physiological abnormalities" EXACT []
is_obsolete: true
consider: MP:0001663
consider: MP:0001756

[Term]
id: MP:0001756
name: abnormal urination
def: "anomaly in the process in which parasympathetic nerves stimulate the bladder wall muscle to contract resulting in the expulsion of urine from the body" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal micturition" EXACT []
synonym: "abnormal urine voiding" RELATED []
xref: GO:0060073
is_a: MP:0005502 ! abnormal renal/urinary system physiology

[Term]
id: MP:0001758
name: abnormal urine glucose level
def: "any change in the amount of glucose in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0001759
name: increased urine glucose level
def: "a greater amount of glucose in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "glucosuria" EXACT []
synonym: "glycosuria" EXACT []
is_a: MP:0001758 ! abnormal urine glucose level

[Term]
id: MP:0001760
name: abnormal urine enzyme level
def: "any change in the level of enzymes in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0001761
name: abnormal urination pattern
def: "increased or decreased frequency of urination episodes, or extended periods of anuria" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001756 ! abnormal urination

[Term]
id: MP:0001762
name: polyuria
def: "increased volume of urine produced and excreted" [https://orcid.org/0000-0003-4606-0597, MGI:cwg]
comment: Clinicians sometimes mistakenly label increased urinary frequency as polyuria (increased urine output); Though rarely used, pollakisuria (or pollakiuria) is the correct term for increased frequency of urination.
subset: IMPC
subset: Sanger_Terms
synonym: "diuresis" EXACT []
synonym: "increased urine output" EXACT []
synonym: "increased urine volume" EXACT []
is_a: MP:0001756 ! abnormal urination

[Term]
id: MP:0001763
name: obsolete Infrequent Urination
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0001761

[Term]
id: MP:0001764
name: abnormal homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues" [ISBN:0-683-40008-8]
synonym: "abnormal homeostatic process" EXACT []
synonym: "homeostasis abnormalities" EXACT []
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0001765
name: abnormal ion homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the fluids and tissues" [MGI:cwg]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0001766
name: obsolete abnormal aluminum level
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001770
name: abnormal iron level
alt_id: MP:0000209
alt_id: MP:0001581
def: "any anomaly in the concentrations of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins and is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [ISBN:0-683-40008-8]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0005637 ! abnormal iron homeostasis

[Term]
id: MP:0001771
name: abnormal circulating magnesium level
def: "any anomaly in the blood concentration of magnesium" [ISBN:0-683-40008-8]
synonym: "abnormal blood magnesium level" EXACT []
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020883 ! abnormal magnesium level

[Term]
id: MP:0001775
name: abnormal selenium level
def: "any anomaly in the concentration of selenium, which is required for glutathione peroxidase and other enzymes" [ISBN:0-683-40008-8]
is_a: MP:0000192 ! abnormal mineral level

[Term]
id: MP:0001776
name: abnormal circulating sodium level
def: "any anomaly in the concentration in the blood of sodium, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [ISBN:0-683-40008-8]
synonym: "abnormal blood sodium level" EXACT []
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020889 ! abnormal sodium level

[Term]
id: MP:0001777
name: abnormal body temperature homeostasis
def: "any anomaly in the process in which an organism modulates or maintains its internal body temperature" [GO:0001659, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal body temperature regulation" EXACT []
synonym: "abnormal temperature regulation" EXACT []
synonym: "abnormal thermoregulation" EXACT []
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0001778
name: abnormal brown adipose tissue amount
alt_id: MP:0000004
def: "anomaly in the amount of the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:cwg]
synonym: "abnormal brown fat amount" EXACT []
is_a: MP:0002971 ! abnormal brown adipose tissue morphology
is_a: MP:0005452 ! abnormal adipose tissue amount

[Term]
id: MP:0001780
name: decreased brown adipose tissue amount
alt_id: MP:0000006
def: "reduced quantity of the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:cwg]
synonym: "decreased brown fat" EXACT []
synonym: "decreased brown fat amount" RELATED []
synonym: "reduced brown fat" EXACT []
synonym: "reduced brown fat amount" EXACT []
is_a: MP:0001778 ! abnormal brown adipose tissue amount

[Term]
id: MP:0001781
name: abnormal white adipose tissue amount
alt_id: MP:0000007
def: "anomaly in the quantity of the white fat-storing cells/tissue" [MGI:cwg]
synonym: "abnormal white fat amount" EXACT []
is_a: MP:0002970 ! abnormal white adipose tissue morphology
is_a: MP:0005452 ! abnormal adipose tissue amount

[Term]
id: MP:0001783
name: decreased white adipose tissue amount
alt_id: MP:0000009
def: "reduced quantity of fat-storing cells/tissue" [MGI:cwg]
synonym: "decreased white fat" EXACT []
synonym: "decreased white fat amount" EXACT []
synonym: "reduced white adipose tissue amount" EXACT []
synonym: "reduced white fat" EXACT []
synonym: "reduced white fat amount" EXACT []
is_a: MP:0001781 ! abnormal white adipose tissue amount

[Term]
id: MP:0001784
name: abnormal fluid regulation
def: "any anomaly in the control of intracellular and/or extracellular fluid" [MGI:cwg]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0001785
name: edema
alt_id: MP:0001338
def: "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "oedema" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation

[Term]
id: MP:0001786
name: skin edema
alt_id: MP:0001207
def: "accumulation of an excessive amount of fluid in the skin layers or just underneath the skin" [J:65039]
synonym: "skin oedema" EXACT []
synonym: "subcutaneous edema" RELATED []
synonym: "subcutaneous oedema" RELATED []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0001785 ! edema

[Term]
id: MP:0001787
name: pericardial edema
alt_id: MP:0000290
def: "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
synonym: "pericardial oedema" EXACT []
synonym: "pericardial sac edema" EXACT []
synonym: "pericardial sac oedema" EXACT []
synonym: "pericardium edema" EXACT []
synonym: "pericardium oedema" EXACT []
is_a: MP:0001785 ! edema
is_a: MP:0012501 ! abnormal pericardial cavity morphology

[Term]
id: MP:0001788
name: periorbital edema
alt_id: MP:0001339
def: "accumulation of an excessive amount of fluid in the area around the orbit" [MGI:tc, PMID:10716451]
synonym: "periorbital oedema" EXACT []
is_a: MP:0001785 ! edema
is_a: MP:0030038 ! abnormal periorbital region morphology

[Term]
id: MP:0001790
name: abnormal immune system physiology
alt_id: MP:0001789
def: "deviation from the normal function of the immune system" [MGI:cwg]
synonym: "immune system/response abnormalities" EXACT []
synonym: "immune system: response/ function abnormalities" EXACT []
xref: GO:0006955
is_a: MP:0005387 ! immune system phenotype

[Term]
id: MP:0001791
name: obsolete immunodeficiency
def: "OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0001792
name: impaired wound healing
def: "reduced ability or inability to self-repair and close wounds" [J:65302, MGI:cwg]
synonym: "impaired wound repair" EXACT []
is_a: MP:0005023 ! abnormal wound healing

[Term]
id: MP:0001793
name: abnormal susceptibility to infection
alt_id: MP:0002548
def: "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "altered resistance to infection" EXACT []
synonym: "altered susceptibility to infection" EXACT []
is_a: MP:0005025 ! abnormal response to infection

[Term]
id: MP:0001794
name: obsolete Bacterial
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001795
name: obsolete Gram Negative
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001796
name: obsolete Gram Positive
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001797
name: obsolete Opportunistic Infections of the Intestinal Tract
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001798
name: impaired macrophage phagocytosis
def: "reduced ability of macrophage phagocytic cells to internalize particulate matter" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "decreased macrophage phagocytosis" EXACT []
is_a: MP:0002451 ! abnormal macrophage physiology
is_a: MP:0008546 ! abnormal vesicle-mediated transport

[Term]
id: MP:0001799
name: obsolete Viral
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001800
name: abnormal humoral immune response
def: "any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination" [https://orcid.org/0000-0003-3691-0324, ISBN:081533642X]
synonym: "abnormal humoural immune response" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "antibody-mediated immune response abnormalities" EXACT []
synonym: "humoral immune response dysfunction" EXACT []
synonym: "humoural immune response dysfunction" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0001802
name: arrested B cell differentiation
alt_id: MP:0002457
def: "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
synonym: "arrested B cell development" EXACT []
synonym: "arrested B lymphocyte development" EXACT []
synonym: "arrested B-cell development" EXACT []
synonym: "failed B cell maturation" EXACT []
synonym: "failed B lymphocyte maturation" EXACT []
synonym: "failed B-cell maturation" EXACT []
synonym: "failure of B cell maturation" EXACT []
synonym: "failure of B lymphocyte maturation" EXACT []
synonym: "failure of B-cell maturation" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation

[Term]
id: MP:0001804
name: obsolete abnormal complement protein physiology
def: "OBSOLETE. functional anomaly of any of the complement proteins" [MGI:cwg]
synonym: "complement protein dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0001805
name: decreased IgG level
alt_id: MP:0001815
def: "less than normal immunoglobulin class G level" [MGI:cwg]
synonym: "decreased serum level of immunoglobulin G" NARROW []
synonym: "reduced IgG level" EXACT []
is_a: MP:0002460 ! decreased immunoglobulin level
is_a: MP:0020174 ! abnormal IgG level

[Term]
id: MP:0001806
name: decreased IgM level
alt_id: MP:0001816
def: "less than normal immunoglobulin class M level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased serum level of immunoglobulin M" NARROW []
synonym: "reduced IgM level" EXACT []
is_a: MP:0002460 ! decreased immunoglobulin level
is_a: MP:0020180 ! abnormal IgM level

[Term]
id: MP:0001807
name: decreased IgA level
def: "less than normal immunoglobulin class A level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced IgA level" EXACT []
is_a: MP:0002460 ! decreased immunoglobulin level
is_a: MP:0020171 ! abnormal IgA level

[Term]
id: MP:0001808
name: obsolete B cell Immunodeficiency
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0008071

[Term]
id: MP:0001809
name: obsolete Abnormal Immunoglobulin Production
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002490

[Term]
id: MP:0001817
name: obsolete abnormal antibody production
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002459
consider: MP:0002490

[Term]
id: MP:0001818
name: obsolete abnormal antibody titer
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002459
consider: MP:0002490

[Term]
id: MP:0001819
name: abnormal immune cell physiology
def: "any functional anomaly of the cells of the immune system" [MGI:cwg]
synonym: "immune cell dysfunction" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0001820
name: obsolete abnormal activated B cell number
def: "OBSOLETE." []
synonym: "abnormal activated B lymphocyte number" EXACT []
synonym: "abnormal activated B-cell number" EXACT []
is_obsolete: true

[Term]
id: MP:0001823
name: thymus hypoplasia
alt_id: MP:0000707
def: "decrease in the number of normal cells in normal arrangement in the thymus, typically resulting in decreased size" [MGI:cwg]
synonym: "decreased thymus cellularity" RELATED []
synonym: "hypoplastic thymus" EXACT []
synonym: "thymic hypoplasia" EXACT []
is_a: MP:0000706 ! small thymus

[Term]
id: MP:0001824
name: abnormal thymus involution
alt_id: MP:0000710
def: "premature or late decline in thymic function normally associated with advancing age" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal thymic involution" EXACT []
synonym: "involuted thymus" EXACT []
is_a: MP:0003763 ! abnormal thymus physiology

[Term]
id: MP:0001825
name: arrested T cell differentiation
def: "failure of T cell formation to proceed past a defined stage" [MGI:cwg]
synonym: "arrested T cell development" EXACT []
synonym: "arrested T-cell development" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation

[Term]
id: MP:0001828
name: abnormal T cell activation
def: "anomaly in the process of producing effector T cells from naive T cells" [ISBN:0-8153-1691-7, MGI:cwg]
comment: This process requires recognition of a foreign peptide fragment bound to self-MHC and the simultaneous delivery of a co-stimulatory signal by an antigen presenting cell; it results in the clonal expansion of naive T cells and their differentiation into armed effector cells.
synonym: "abnormal T-cell activation" EXACT []
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0001829
name: increased activated T cell number
alt_id: MP:0000320
def: "greater than normal numbers of effector T cells" [MGI:cwg]
synonym: "increased activated T-cell number" EXACT []
is_a: MP:0005015 ! increased T cell number

[Term]
id: MP:0001830
name: decreased activated T cell number
alt_id: MP:0000331
def: "reduced numbers of effector T cells" [MGI:cwg]
synonym: "decreased activated T-cell number" EXACT []
synonym: "reduced activated T cell number" EXACT []
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0001831
name: obsolete T cell immunodeficiency
alt_id: MP:0002537
def: "OBSOLETE.defective immune response due to defective T-lymphocyte response" [ISBN:0-683-40008-8]
synonym: "T-cell deficiency" EXACT []
synonym: "T-cell immunodeficiency" EXACT []
is_obsolete: true
consider: MP:0008070

[Term]
id: MP:0001832
name: obsolete CD4-Positive cell immunodeficiency
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0003790

[Term]
id: MP:0001833
name: obsolete CD8- Positive cell immunodeficiency
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0000727

[Term]
id: MP:0001834
name: obsolete macrophage immunodeficiency/impairment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002451

[Term]
id: MP:0001835
name: abnormal antigen presentation
def: "aberration in the process by which by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex" [GO:0019882]
synonym: "antigen presentation dysfunction" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0001836
name: abnormal antigen presentation via MHC class I
def: "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [MGI:cwg]
synonym: "inability to present cytosolic antigens to Class-I restricted cytotoxic T cells" EXACT []
is_a: MP:0001835 ! abnormal antigen presentation

[Term]
id: MP:0001837
name: defective assembly of class I molecules
def: "impaired production of major histocompatibility complex class I molecules" [MGI:cwg]
is_a: MP:0001836 ! abnormal antigen presentation via MHC class I

[Term]
id: MP:0001838
name: defective intracellular transport of class I molecules
def: "impaired ability to move major histocompatibility complex class I molecules to the cell surface" [MGI:cwg]
is_a: MP:0001836 ! abnormal antigen presentation via MHC class I

[Term]
id: MP:0001839
name: abnormal level of surface class I molecules
def: "deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface" [ISBN:0-8153-1691-7, MGI:cwg]
comment: Almost all nucleated blood cells express class I molecules on their surfaces (red blood cells, being non-nucleated, do not); MHC class I molecules present peptides from pathogens in the cytosol (often viruses) to CD8 T cells.
is_a: MP:0001836 ! abnormal antigen presentation via MHC class I

[Term]
id: MP:0001840
name: increased level of surface class I molecules
def: "greater than normal expression of major histocompatibility complex class I molecules at the cell surface" [MGI:cwg]
is_a: MP:0001839 ! abnormal level of surface class I molecules

[Term]
id: MP:0001841
name: decreased level of surface class I molecules
def: "reduced expression of major histocompatibility complex class I molecules at the cell surface" [MGI:cwg]
synonym: "reduced level of surface class I molecules" EXACT []
is_a: MP:0001839 ! abnormal level of surface class I molecules

[Term]
id: MP:0001842
name: obsolete inability to present cytosolic antigens to Class-I restricted cytotoxic T cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001844
name: autoimmune response
def: "condition in which cells and/or antibodies arise from and are directed against one's own tissues" [ISBN:0-683-40008-8]
is_a: MP:0005005 ! abnormal self tolerance

[Term]
id: MP:0001845
name: abnormal inflammatory response
def: "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [ISBN:0-397-51047-0]
synonym: "inflammation" EXACT []
synonym: "inflammatory response" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0001846
name: increased inflammatory response
def: "greater than expected response to injury, infection, or insult" [MGI:cwg]
is_a: MP:0001845 ! abnormal inflammatory response

[Term]
id: MP:0001847
name: brain inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "encephalitis" EXACT []
is_a: MP:0006082 ! CNS inflammation

[Term]
id: MP:0001848
name: choroid inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [ISBN:0-8153-1691-7]
synonym: "choroiditis" EXACT []
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0001849
name: ear inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the ear" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0001850
name: increased susceptibility to otitis media
alt_id: MP:0000050
def: "greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection" [ISBN:0-683-40008-8, PMID:10716451]
is_a: MP:0001849 ! ear inflammation

[Term]
id: MP:0001851
name: eye inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0001852
name: conjunctivitis
alt_id: MP:0001311
def: "inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball" [ISBN:0-683-40008-8, PMID:10716451]
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0001853
name: heart inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "cardiac inflammation" EXACT []
synonym: "carditis" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0001854
name: atrial endocarditis
def: "inflammation affecting the atrial chambers of the heart" [MGI:cwg]
is_a: MP:0001853 ! heart inflammation

[Term]
id: MP:0001855
name: abnormal atrial thrombosis
def: "any anomaly in the formation or presence of one or more thrombi in the atria of the heart" [MGI:cwg]
synonym: "abnormal cardiac atrial thrombosis" EXACT []
synonym: "abnormal heart atrial thrombosis" EXACT []
synonym: "abnormal heart atrium thrombosis" EXACT []
is_a: MP:0020409 ! abnormal cardiac thrombosis

[Term]
id: MP:0001856
name: myocarditis
def: "inflammation of the heart walls" [MESH:C14.280.238.625, MGI:cwg]
is_a: MP:0001853 ! heart inflammation

[Term]
id: MP:0001857
name: pericarditis
def: "inflammation of the pericardium, the fibroserous sac surrounding the heart and the roots of the great vessels" [MESH:C14.280.720, MGI:cwg]
is_a: MP:0001853 ! heart inflammation

[Term]
id: MP:0001858
name: intestinal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "g.i. inflammation" BROAD []
synonym: "gastrointestinal inflammation" BROAD []
synonym: "inflammation of intestine" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0010155 ! abnormal intestine physiology

[Term]
id: MP:0001859
name: kidney inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "nephritis" EXACT []
synonym: "renal inflammation" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0011762 ! renal/urinary system inflammation

[Term]
id: MP:0001860
name: liver inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "hepatic inflammation" EXACT []
synonym: "hepatitis" EXACT []
is_a: MP:0000609 ! abnormal liver physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0001861
name: lung inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "pneumonia" EXACT []
synonym: "pulmonary inflammation" EXACT []
is_a: MP:0002405 ! respiratory system inflammation

[Term]
id: MP:0001862
name: interstitial pneumonia
def: "any of a group of inflammatory and fibrotic disorders of the lower respiratory tract, primarily affecting the supporting framework of the lung, including the alveolar wall, but may also involve the small airways and blood vessels of the lung parenchyma" [ISBN:0-683-40008-8]
synonym: "interstitial pneumonitis" EXACT []
is_a: MP:0001861 ! lung inflammation

[Term]
id: MP:0001863
name: blood vessel inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "angiitis" RELATED []
synonym: "vasculitis" RELATED []
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0001864 ! vascular inflammation

[Term]
id: MP:0001864
name: vascular inflammation
def: "inflammation of any blood and/or lymphatic vessel" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "vessel inflammation" EXACT []
is_a: MP:0031170 ! abnormal vasculature physiology

[Term]
id: MP:0001866
name: nasal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002405 ! respiratory system inflammation

[Term]
id: MP:0001867
name: rhinitis
alt_id: MP:0001113
def: "inflammation of the mucous membrane of the nose" [ISBN:0-683-40008-8, MGI:tc, PMID:10716451]
synonym: "nasal catarrh" EXACT []
is_a: MP:0001866 ! nasal inflammation

[Term]
id: MP:0001868
name: ovary inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the ovary" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "oophoritis" EXACT []
synonym: "ovarian inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0003507 ! abnormal ovary physiology

[Term]
id: MP:0001869
name: pancreas inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "pancreatic inflammation" EXACT []
synonym: "pancreatitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002693 ! abnormal pancreas physiology

[Term]
id: MP:0001870
name: salivary gland inflammation
alt_id: MP:0000625
alt_id: MP:0000626
alt_id: MP:001871
def: "local accumulation of fluid, plasma proteins, and leukocytes in one or more salivary glands" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "increased inflammatory response of the salivary glands" EXACT []
synonym: "salivary gland adenitis" EXACT []
synonym: "sialadenitis" EXACT []
synonym: "sialitis" EXACT []
synonym: "sialoadenitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005310 ! abnormal salivary gland physiology

[Term]
id: MP:0001872
name: sinus inflammation
def: "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, PMID:10716451]
synonym: "sinusitis" EXACT []
is_a: MP:0002405 ! respiratory system inflammation

[Term]
id: MP:0001873
name: stomach inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "gastritis" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0001874
name: acanthosis
def: "diffuse hyperplasia of the spinous layer of the skin" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "spinous layer hyperplasia" BROAD []
is_a: MP:0009611 ! epidermis stratum spinosum hyperplasia

[Term]
id: MP:0001875
name: testis inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the testis" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "orchitis" EXACT []
synonym: "testicle inflammation" EXACT []
synonym: "testicular inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0004884 ! abnormal testis physiology

[Term]
id: MP:0001876
name: decreased inflammatory response
def: "less than expected response to injury, infection, or insult" [MGI:cwg]
synonym: "reduced inflammatory response" EXACT []
is_a: MP:0001845 ! abnormal inflammatory response

[Term]
id: MP:0001877
name: obsolete dysregulated inflammatory response
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001879
name: abnormal lymphatic vessel morphology
alt_id: MP:0000309
alt_id: MP:0001638
alt_id: MP:0001639
def: "any structural anomaly of any component of the network of vessels that carries lymph around the body" [ISBN:0-683-40008-8, MGI:tc]
synonym: "abnormal lymph vessel morphology" EXACT []
synonym: "lymphatic system abnormalities" BROAD []
synonym: "lymphatic system dysplasia" NARROW []
is_a: MP:0000685 ! abnormal immune system morphology

[Term]
id: MP:0001881
name: abnormal mammary gland physiology
def: "any functional anomaly of the compound, alveolar and apocrine milk-secreting gland that lies within the breast" [ISBN:0-683-40008-8]
synonym: "abnormal breast physiology" EXACT []
synonym: "abnormal Brustdruese physiology" EXACT []
synonym: "abnormal glandula mammaria physiology" EXACT []
synonym: "abnormal Lactiferous gland physiology" EXACT []
synonym: "abnormal lactiferous gland physiology" EXACT []
synonym: "abnormal Lobe of breast physiology" EXACT []
synonym: "abnormal lobe of breast physiology" EXACT []
synonym: "abnormal Lobe of mammary gland physiology" EXACT []
synonym: "abnormal lobe of mammary gland physiology" EXACT []
synonym: "abnormal mamma physiology" EXACT []
synonym: "abnormal mammae physiology" EXACT []
synonym: "abnormal mammary gland function" EXACT []
synonym: "mammary gland abnormalities" BROAD []
is_a: MP:0010680 ! abnormal skin adnexa physiology
is_a: MP:0013555 ! abnormal apocrine gland physiology

[Term]
id: MP:0001882
name: abnormal lactation
alt_id: MP:0001383
def: "atypical production of milk from the mammary gland" [J:51296]
synonym: "lactation abnormalities" EXACT []
synonym: "lactation defects" EXACT []
is_a: MP:0001881 ! abnormal mammary gland physiology

[Term]
id: MP:0001883
name: increased mammary adenocarcinoma incidence
alt_id: MP:0002011
def: "higher than normal incidence of malignant tumors of the mammary gland" [https://orcid.org/0000-0003-4606-0597]
synonym: "mammary adenocarcinoma" RELATED []
synonym: "mammary carcinoma" RELATED []
synonym: "mammary gland adenocarcinoma" RELATED []
synonym: "mammary gland carcinoma" RELATED []
is_a: MP:0009308 ! increased adenocarcinoma incidence
is_a: MP:0010299 ! increased mammary gland tumor incidence

[Term]
id: MP:0001884
name: mammary gland alveolar hyperplasia
def: "increase in the number of normal cells in normal arrangement in the mammary gland alveoli, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic mammary gland alveoli" EXACT []
synonym: "mammary alveolar hyperplasia" EXACT []
is_a: MP:0009506 ! abnormal mammary gland alveolus morphology

[Term]
id: MP:0001885
name: mammary gland duct hyperplasia
def: "increase in the number of normal cells in normal arrangement in the mammary gland ducts, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic mammary gland ducts" EXACT []
synonym: "mammary ductal hyperplasia" RELATED []
is_a: MP:0009503 ! abnormal mammary gland duct morphology

[Term]
id: MP:0001886
name: obsolete nervous system physiology abnormalities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal nervous system physiology" EXACT []
is_obsolete: true
replaced_by: MP:0003633

[Term]
id: MP:0001889
name: delayed brain development
def: "the delay or slower progress of the growth and differentiation of the brain" [J:81818, MGI:il]
synonym: "developmental retardation of the brain" EXACT []
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0001890
name: anencephaly
alt_id: MP:0000915
def: "anomaly that occurs when the anterior neuropore of the neural tube fails to close, resulting in the congenital partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp; in affected organisms, the forebrain remains in contact with the amniotic fluid and subsequently degenerates, including the cerebrum (areas responsible for cognition); any remaining brain tissue, such as the brain stem, is often exposed" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "anencephalia" EXACT []
xref: Fyler:4332
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0001891
name: hydrocephaly
alt_id: MP:0000916
def: "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [ISBN:0-683-40008-8, MESH:C10.228.140.602]
subset: IMPC
subset: Sanger_Terms
synonym: "hydrocephalus" EXACT []
synonym: "hydroencephaly" EXACT []
is_a: MP:0000913 ! abnormal brain development
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0001893
name: non-obstructive hydrocephaly
alt_id: MP:0000918
def: "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "Communicating Hydrocephalus" EXACT []
synonym: "communicating hydrocephaly" EXACT []
is_a: MP:0001891 ! hydrocephaly

[Term]
id: MP:0001895
name: obsolete abnormal hippocampus function
def: "OBSOLETE. any anomaly in the activity of the deep lying structure of the cerebrum involved with memory storage" [MGI:hdene]
is_obsolete: true

[Term]
id: MP:0001898
name: abnormal long-term depression
alt_id: MP:0001474
def: "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "abnormal long term depression" EXACT []
synonym: "abnormal LTD" EXACT []
is_a: MP:0002915 ! abnormal synaptic depression

[Term]
id: MP:0001899
name: absent long-term depression
def: "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "absent long term depression" EXACT []
synonym: "absent LTD" EXACT []
is_a: MP:0001898 ! abnormal long-term depression

[Term]
id: MP:0001900
name: impaired synaptic plasticity
def: "decrease or inability of a synapse to change its strength as a result of successive activations" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
is_a: MP:0004859 ! abnormal synaptic plasticity
is_a: MP:0021010 ! impaired synaptic physiology

[Term]
id: MP:0001901
name: absence of NMDA-mediated synaptic currents
def: "absence of a measured amplitude, current density or duration of response to stimulation of NMDA receptors" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of NMDA -mediated synaptic currents: CA1 region" EXACT []
is_a: MP:0002888 ! abnormal NMDA-mediated synaptic currents

[Term]
id: MP:0001902
name: reduced NMDA-mediated synaptic currents
def: "reduction in the measured amplitude, current density or duration of response to stimulation of NMDA receptors" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced NMDA -mediated synaptic currents: CA1 region" EXACT []
is_a: MP:0002888 ! abnormal NMDA-mediated synaptic currents

[Term]
id: MP:0001903
name: obsolete reduced NMDA receptor glycine affinity: hippocampus
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001904
name: obsolete impaired GABA receptor mediated fast inhibition
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001905
name: abnormal dopamine level
def: "greater or less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MESH:D02.092.211.215.311.342, MGI:cwg]
synonym: "abnormal dopaminergic levels" EXACT []
is_a: MP:0011479 ! abnormal catecholamine level

[Term]
id: MP:0001906
name: increased dopamine level
def: "greater than the normal amount of dopamine, a catecholamine neurotransmitter and neurohormone that is derived from tyrosine and is the precursor to norepinephrine and epinephrine; it functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MESH:D02.092.211.215.311.342, MGI:cwg]
synonym: "increased dopaminergic levels" EXACT []
is_a: MP:0001905 ! abnormal dopamine level

[Term]
id: MP:0001907
name: obsolete abnormal cerebellar function
def: "OBSOLETE. any anomaly in the activity of the portion of the brain in the back of the head between the cerebrum and the pons that controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0001908
name: abnormal somatosensory cortex physiology
def: "any functional anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [ISBN:0-683-40008-8, MESH:A08.186.211.730.885.287.500.670.675]
synonym: "abnormal somatic sensory cortex function" EXACT []
synonym: "abnormal somatic sensory cortex physiology" EXACT []
synonym: "abnormal somatosensory cortex function" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0001909
name: reduced NMDA receptor mediated synaptic activity in barrel cortex
def: "lower than normal levels of excitatory synaptic current in the barrel cortex" [ISBN:0838580343, J:64064]
is_a: MP:0001908 ! abnormal somatosensory cortex physiology
is_a: MP:0002888 ! abnormal NMDA-mediated synaptic currents

[Term]
id: MP:0001911
name: abnormal cerebrospinal fluid production
def: "anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord" [ISBN:0-683-40008-8]
is_a: MP:0021024 ! abnormal cerebrospinal fluid physiology

[Term]
id: MP:0001912
name: increased cerebrospinal fluid production
def: "increase in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord" [ISBN:0-683-40008-8]
is_a: MP:0001911 ! abnormal cerebrospinal fluid production

[Term]
id: MP:0001913
name: decreased cerebrospinal fluid production
def: "reduction in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord" [ISBN:0-683-40008-8]
synonym: "reduced cerebrospinal fluid production" EXACT []
is_a: MP:0001911 ! abnormal cerebrospinal fluid production

[Term]
id: MP:0001914
name: hemorrhage
alt_id: MP:0001635
def: "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "bleeding" EXACT []
synonym: "haemorrhage" EXACT []
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0001915
name: intracranial hemorrhage
def: "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [https://orcid.org/0000-0003-3691-0324]
synonym: "intracranial bleeding" EXACT []
synonym: "intracranial haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0001916
name: intracerebral hemorrhage
def: "bleeding within the cerebrum" [MGI:cwg]
synonym: "cerebral haemorrhage" EXACT []
synonym: "cerebral hemorrhage" EXACT []
synonym: "intracerebral bleeding" EXACT []
synonym: "intracerebral haemorrhage" EXACT []
is_a: MP:0001915 ! intracranial hemorrhage

[Term]
id: MP:0001917
name: intraventricular hemorrhage
def: "bleeding into the brain ventricles" [MGI:cwg]
synonym: "intraventricular bleeding" EXACT []
synonym: "intraventricular haemorrhage" EXACT []
is_a: MP:0001916 ! intracerebral hemorrhage

[Term]
id: MP:0001919
name: abnormal reproductive system physiology
def: "any functional anomaly of the organs associated with producing offspring" [https://orcid.org/0000-0003-3691-0324]
synonym: "reproductive system physiology anomalies" EXACT []
is_a: MP:0005389 ! reproductive system phenotype

[Term]
id: MP:0001921
name: reduced fertility
alt_id: MP:0001372
def: "diminished physiological ability to produce live offspring" [J:65030]
synonym: "decreased fecundity" EXACT []
synonym: "hypofertile" EXACT []
synonym: "semi-sterile" EXACT []
synonym: "semisterile" EXACT []
synonym: "subfertile" EXACT []
synonym: "subfertility" EXACT []
is_a: MP:0002161 ! abnormal fertility/fecundity

[Term]
id: MP:0001922
name: reduced male fertility
def: "reduced physiological ability of a male organism to produce live offspring" [ISBN:0-683-40008-8]
synonym: "male subfertility" EXACT []
is_a: MP:0001921 ! reduced fertility
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0001923
name: reduced female fertility
def: "reduced physiological ability of a female organism to produce live offspring" [ISBN:0-683-40008-8]
synonym: "female subfertility" RELATED []
synonym: "low pregnancy rate" NARROW []
is_a: MP:0001921 ! reduced fertility
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0001924
name: infertility
alt_id: MP:0001371
def: "physiological inability to produce live offspring" [J:47225]
comment: This term is independent of any anomalies in mating behavior. Consider using abnormal sexual interaction MP:0002566 when anomalies in mating behavior are observed.
synonym: "infertile" EXACT []
synonym: "sterile" EXACT []
synonym: "sterility" EXACT []
is_a: MP:0002161 ! abnormal fertility/fecundity

[Term]
id: MP:0001925
name: male infertility
def: "physiological inability of a male organism to produce live offspring" [ISBN:0-683-40008-8]
synonym: "male infertile" EXACT []
synonym: "male sterile" EXACT []
synonym: "male sterility" EXACT []
is_a: MP:0001924 ! infertility
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0001926
name: female infertility
def: "physiological inability of a female organism to produce live offspring" [ISBN:0-683-40008-8]
synonym: "female infertile" EXACT []
synonym: "female sterile" EXACT []
synonym: "female sterility" EXACT []
is_a: MP:0001924 ! infertility
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0001927
name: abnormal estrous cycle
def: "failure of progression or aberrant timing of the regular female reproductive cycle of non-primate placental mammals that is under hormonal control and includes a period of heat (mating receptivity), followed by ovulation and complex changes in the reproductive tract, followed by reabsorption of the endometrium if pregnancy does not occur" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal estrus cycle" EXACT []
synonym: "abnormal oestrous cycle" EXACT []
is_a: MP:0009344 ! abnormal ovulation cycle

[Term]
id: MP:0001928
name: abnormal ovulation
def: "aberration in the release of an ovum from a rupturing Graafian follicle, normally regulated by a surge in luteinizing hormone" [MGI:cwg]
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0001929
name: abnormal gametogenesis
def: "defective formation or differentiation of germ cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0001930
name: abnormal meiosis
def: "anomaly in the process of nuclear division that results in gametes with one half the normal number of the original cell" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001929 ! abnormal gametogenesis
is_a: MP:0003077 ! abnormal cell cycle

[Term]
id: MP:0001931
name: abnormal oogenesis
def: "atypical formation or failure to form the female germ cells" [ISBN:0-683-40008-8, J:35782]
is_a: MP:0001929 ! abnormal gametogenesis
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0001932
name: abnormal spermiogenesis
def: "anomaly in the process by which a spermatid transforms into a functional spermatozoon" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal spermatid cell development" EXACT [GO:0007286]
synonym: "abnormal spermatid development" EXACT [GO:0007286]
is_a: MP:0001156 ! abnormal spermatogenesis

[Term]
id: MP:0001933
name: abnormal litter size
def: "deviation from the normal number of live born pups in a litter" [MGI:cwg]
is_a: MP:0002161 ! abnormal fertility/fecundity

[Term]
id: MP:0001934
name: increased litter size
alt_id: MP:0002290
def: "greater numbers of live born pups in a litter compared to average" [https://orcid.org/0000-0003-3691-0324]
synonym: "large litter size" EXACT []
is_a: MP:0001933 ! abnormal litter size
is_a: MP:0010143 ! enhanced fertility

[Term]
id: MP:0001935
name: decreased litter size
alt_id: MP:0002289
def: "fewer live born pups in a litter compared to average" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced litter size" RELATED []
synonym: "small litter size" EXACT []
is_a: MP:0001921 ! reduced fertility
is_a: MP:0001933 ! abnormal litter size

[Term]
id: MP:0001937
name: abnormal sexual maturation
def: "a delay or a block in the development of the sexual organs at a given age" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002212 ! abnormal secondary sex determination

[Term]
id: MP:0001938
name: delayed sexual maturation
def: "immaturity of the sexual organs at a given age" [J:61190]
synonym: "delayed onset of sexual maturity" EXACT []
synonym: "delayed sexual maturity" EXACT []
is_a: MP:0001937 ! abnormal sexual maturation

[Term]
id: MP:0001939
name: secondary sex reversal
def: "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex" [MGI:llw2]
is_a: MP:0002212 ! abnormal secondary sex determination
is_a: MP:0005652 ! sex reversal

[Term]
id: MP:0001940
name: testis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the testis, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypoplastic testes" EXACT []
synonym: "testes hypoplasia" EXACT []
synonym: "testicle hypoplasia" EXACT []
synonym: "testicular hypoplasia" EXACT []
is_a: MP:0001147 ! small testis

[Term]
id: MP:0001942
name: abnormal lung volume
def: "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MESH:E01.370.386.700.485, MGI:cwg]
synonym: "abnormal lung capacity" RELATED []
synonym: "abnormal lung volume measurements" EXACT []
is_a: MP:0001943 ! abnormal respiration

[Term]
id: MP:0001943
name: abnormal respiration
def: "anomaly in the movement of gases into and out of the lung" [ISBN:0-683-40008-8, MGI:cwg]
subset: CvDC_Terms
synonym: "respiratory anomaly" EXACT []
xref: Fyler:4200
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0001944
name: abnormal pancreas morphology
def: "any structural anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ISBN:0-683-40008-8, MGI:il]
synonym: "pancreas dysplasia" NARROW []
synonym: "pancreatic dysplasia" NARROW []
is_a: MP:0002163 ! abnormal gland morphology

[Term]
id: MP:0001945
name: bronchoconstriction
def: "reduction in the caliber of the bronchus or bronchi" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0002314 ! abnormal respiratory mechanics

[Term]
id: MP:0001947
name: abnormal mucociliary clearance
def: "anomaly in the mechanism that removes mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [https://orcid.org/0000-0003-0431-8641, https://orcid.org/0000-0003-3691-0324, MESH:E01.370.386.520]
synonym: "abnormal lung bacterial clearance" NARROW []
synonym: "abnormal lung clearance" EXACT []
synonym: "abnormal mucociliary transport" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0001948
name: vesicoureteral reflux
def: "the retrograde flow of urine from the bladder into the ureters and kidneys" [https://orcid.org/0000-0002-0371-1954]
subset: CvDC_Terms
synonym: "ureteral reflux" EXACT []
synonym: "vesicoureteric reflux" EXACT []
synonym: "VUR" EXACT []
synonym: "VUX" EXACT []
xref: Fyler:4510
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0001949
name: obsolete abnormal respiratory dead space
def: "OBSOLETE. anomaly in the section of the respiratory tract that does not exchange oxygen and carbon dioxide with pulmonary capillary blood" [MESH:G09.772.765.760, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0001950
name: abnormal respiratory sounds
def: "any anomaly in the noises heard over any part of the respiratory tract" [MESH:C23.888.852.779]
is_a: MP:0001943 ! abnormal respiration

[Term]
id: MP:0001951
name: abnormal breathing pattern
alt_id: MP:0001955
def: "irregular or atypical breathing pattern, or absence of breathing" [ISBN:0-683-40008-8, PMID:7914451]
synonym: "irregular breathing" EXACT []
is_a: MP:0002327 ! abnormal respiratory function

[Term]
id: MP:0001952
name: increased airway responsiveness
def: "more easily provoked into bronchoconstriction in bronchial provocation tests" [MGI:cwg]
synonym: "airway hyperresponsiveness" EXACT []
is_a: MP:0002334 ! abnormal airway responsiveness

[Term]
id: MP:0001953
name: respiratory failure
def: "cessation of or failure to commence breathing" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0014274 ! decreased respiration

[Term]
id: MP:0001954
name: respiratory distress
alt_id: MP:0002317
def: "physical difficulty or impaired ability to breathe; signs include: shortness of breath, labored breathing, gasping, increased work of breathing, inadequate respiratory effort, and/or irregular breathing" [https://www.timeofcare.com/respiratory-distress-failure-arrest/, ISBN:0-683-40008-8, MESH:C08.618.326, PMID:10357937]
synonym: "dyspnea" NARROW []
synonym: "dyspnoea" NARROW []
synonym: "gasping" NARROW []
synonym: "labored breathing" NARROW []
synonym: "laboured breathing" NARROW []
synonym: "shortness of breath" NARROW []
is_a: MP:0001951 ! abnormal breathing pattern

[Term]
id: MP:0001956
name: hypopnea
def: "breathing that is shallower and/or slower than normal" [ISBN:0-683-40008-8, J:64289]
synonym: "hypopnoea" EXACT []
is_a: MP:0001951 ! abnormal breathing pattern

[Term]
id: MP:0001957
name: apnea
def: "temporary cessation of breathing; sometimes episodic" [ISBN:0-683-40008-8, MESH:C08.618.085]
synonym: "apnoea" EXACT []
is_a: MP:0001951 ! abnormal breathing pattern

[Term]
id: MP:0001958
name: emphysema
def: "an abnormal condition of the lung characterized by permanent enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis; results in decreased respiratory function including increased air retention and reduced exchange of gases" [ISBN:0-683-40008-8]
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0010911 ! abnormal pulmonary acinus morphology

[Term]
id: MP:0001959
name: obsolete sensory system physiology/response abnormalities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal sensory system physiology/response" EXACT []
xref: GO:0007600
is_obsolete: true

[Term]
id: MP:0001961
name: abnormal reflex
alt_id: MP:0001476
def: "anomaly in an involuntary response to a peripheral stimulus" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002067 ! abnormal sensory capabilities/reflexes/nociception
is_a: MP:0003492 ! abnormal involuntary movement

[Term]
id: MP:0001963
name: abnormal hearing physiology
alt_id: MP:0001960
alt_id: MP:0002104
def: "any functional anomaly in the ability to perceive auditory stimuli" [ISBN:0-683-40008-8]
synonym: "abnormal auditory perception" EXACT []
synonym: "abnormal auditory physiology" EXACT []
synonym: "auditory abnormalities" BROAD []
synonym: "ears: auditory defects/deafness" EXACT []
xref: GO:0007605
xref: MGI:2173555
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0001964
name: obsolete abnormal auditory threshold
def: "OBSOLETE. change in the average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency" [https://orcid.org/0000-0002-0371-1954]
xref: GO:0007605
is_obsolete: true
consider: MP:0006335

[Term]
id: MP:0001965
name: obsolete increased auditory threshold
def: "OBSOLETE. a greater than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency" [https://orcid.org/0000-0002-0371-1954]
synonym: "hearing disability" EXACT []
synonym: "hearing impairment" EXACT []
is_obsolete: true
consider: MP:0006335

[Term]
id: MP:0001966
name: obsolete decreased auditory threshold
def: "OBSOLETE. a lower than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency" [https://orcid.org/0000-0002-0371-1954]
synonym: "hypersensitive hearing" EXACT []
is_obsolete: true
consider: MP:0006335

[Term]
id: MP:0001967
name: deafness
def: "inability to hear; the ability to detect and/or recognize certain frequencies of sound is completely impaired" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "complete hearing loss" EXACT []
synonym: "impaired perception of sound" EXACT []
synonym: "impaired sensory perception of sound" EXACT []
xref: Fyler:4868
xref: GO:0007605
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0001968
name: abnormal touch/ nociception
def: "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [MGI:cwg]
synonym: "touch/ nociception abnormalities" EXACT []
synonym: "touch/ nociception defects" EXACT []
is_a: MP:0002067 ! abnormal sensory capabilities/reflexes/nociception

[Term]
id: MP:0001970
name: abnormal pain threshold
def: "increased or decreased average level of perception of pain" [J:17792]
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0001973
name: increased thermal nociceptive threshold
def: "a greater than average point at which thermal pain sensation is first detectable" [ISBN:0-471-31639-3]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased thermal nociception" EXACT []
synonym: "prolonged latency in hot plate test" EXACT []
synonym: "thermal hypoalgesia" EXACT []
is_a: MP:0002733 ! abnormal thermal nociception
is_a: MP:0003043 ! hypoalgesia

[Term]
id: MP:0001974
name: obsolete toe pinch
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001975
name: obsolete tail pinch
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001977
name: obsolete tail flick
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001978
name: obsolete prolonged latency in tail flick test
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001980
name: abnormal chemically-elicited antinociception
def: "change in the analgesic effect of chemical substances" [MGI:cwg]
synonym: "abnormal chemically-elicited analgesia" EXACT []
is_a: MP:0001970 ! abnormal pain threshold

[Term]
id: MP:0001981
name: increased chemically-elicited antinociception
def: "greater than the normal analgesic effect of chemical substances" [MGI:cwg]
synonym: "enhanced chemically-elicited antinociception" EXACT []
synonym: "enhanced chemically-induced analgesia" EXACT []
is_a: MP:0001980 ! abnormal chemically-elicited antinociception

[Term]
id: MP:0001982
name: decreased chemically-elicited antinociception
def: "less than the normal analgesic effect of chemical substances" [MGI:cwg]
synonym: "reduced chemically-elicited antinociception" EXACT []
synonym: "reduced chemically-induced analgesia" EXACT []
is_a: MP:0001980 ! abnormal chemically-elicited antinociception

[Term]
id: MP:0001983
name: abnormal olfactory system physiology
alt_id: MP:0001110
alt_id: MP:0001111
def: "any functional anomaly of the system relating to smell" [MGI:cwg]
synonym: "abnormal olfactory system function" EXACT []
synonym: "olfactory abnormalities" BROAD []
synonym: "olfactory defects" BROAD []
synonym: "olfactory system abnormalities" BROAD []
is_a: MP:0005394 ! taste/olfaction phenotype

[Term]
id: MP:0001984
name: abnormal olfaction
def: "anomaly in the ability to smell" [ISBN:0-683-40008-8]
is_a: MP:0001983 ! abnormal olfactory system physiology

[Term]
id: MP:0001985
name: abnormal gustatory system physiology
def: "any functional anomaly in the perception of taste" [ISBN:0-683-40008-8]
synonym: "abnormal taste physiology" EXACT []
synonym: "abnormal taste response" EXACT []
is_a: MP:0005394 ! taste/olfaction phenotype

[Term]
id: MP:0001986
name: abnormal taste sensitivity
def: "changes in the ability to perceive a particular flavor(s) or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001985 ! abnormal gustatory system physiology

[Term]
id: MP:0001987
name: alcohol preference
def: "predilection to ingest alcohol over other substances" [https://orcid.org/0000-0003-3691-0324]
synonym: "ethanol preference" EXACT []
is_a: MP:0001423 ! abnormal liquid preference
is_a: MP:0001425 ! abnormal alcohol consumption
is_a: MP:0002553 ! preference for addictive substance

[Term]
id: MP:0001988
name: cocaine preference
def: "predilection to ingest cocaine over other substances" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002553 ! preference for addictive substance
is_a: MP:0020905 ! abnormal cocaine self-administration

[Term]
id: MP:0001989
name: obsolete saccharin versus water
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001990
name: obsolete water versus saccharin
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0001993
name: abnormal blinking
alt_id: MP:0001478
def: "anomaly in the normal reflex of closing the eyes frequently and rapidly" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
synonym: "blinking abnormalities" EXACT []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0001994
name: increased blinking frequency
alt_id: MP:0001479
def: "greater number of occurrences of the normal reflex of closing the eyes frequently and rapidly" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased blinking" EXACT []
is_a: MP:0001993 ! abnormal blinking

[Term]
id: MP:0001995
name: decreased blinking frequency
alt_id: MP:0001480
def: "reduced number of occurrences of the normal reflex of closing the eyes frequently and rapidly" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased blinking" EXACT []
synonym: "reduced blinking frequency" RELATED []
is_a: MP:0001993 ! abnormal blinking

[Term]
id: MP:0001997
name: obsolete Increased Pupil Constriction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002638

[Term]
id: MP:0001998
name: obsolete Decreased Pupil Constriction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0002638

[Term]
id: MP:0001999
name: photosensitivity
alt_id: MP:0001484
def: "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "photosensitivity abnormalities" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0002001
name: blindness
def: "loss of the sense of sight" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:4866
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0002002
name: obsolete abnormal response to visual cliff
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002003
name: miotic pupil
alt_id: MP:0001481
alt_id: MP:0001996
def: "decreased diameter of one or both pupils due to abnormal constriction of the muscles of the iris" [J:17194]
synonym: "abnormal pupil constriction" EXACT []
synonym: "constricted pupils" EXACT []
synonym: "meiotic pupils" RELATED []
synonym: "miotic pupils" EXACT []
synonym: "myotic pupils" EXACT []
synonym: "pinpoint pupils" NARROW []
synonym: "pupillary constriction" EXACT []
synonym: "pupillary miosis" EXACT []
is_a: MP:0001320 ! small pupil

[Term]
id: MP:0002006
name: neoplasm
def: "the observable morphological and physiological characteristics of  a benign or malignant tissue growth resulting from uncontrolled cell proliferation in a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597, URL:https\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3262]
synonym: "tumorigenesis" NARROW []
synonym: "tumourigenesis" NARROW []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0002007
name: increased cellular sensitivity to gamma-irradiation
def: "increased incidence of cell death following exposure to gamma-irradiation" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cellular resistance to gamma-irradiation" EXACT []
synonym: "increased cellular susceptibility to gamma-irradiation" EXACT []
is_a: MP:0004227 ! increased cellular sensitivity to ionizing radiation

[Term]
id: MP:0002009
name: preneoplasia
def: "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
is_a: MP:0002166 ! abnormal tumor susceptibility

[Term]
id: MP:0002010
name: obsolete hepatic microgranulomas
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002012
name: increased trichofolliculoma incidence
def: "greater than the expected number of dome-shaped hamartoma tumors which contain multiple abortive and/or misaligned hair follicles" [PMID:23409475]
is_a: MP:0009469 ! increased skin hamartoma incidence

[Term]
id: MP:0002013
name: increased pilomatricoma incidence
def: "greater than the expected number of neoplasms that arise from hair matrix cells occurring in a specific population in a given time period; pilomatricoma is an encapsulated tumor containing irregularly shaped, lobules of cells separated by fibrovascular connective tissue stroma; two distinct cell populations comprise this tumor, basaloid cells with scant cytoplasm located towards the periphery and the ghost (or shadow) cells occupying the central portion" [http://atlasgeneticsoncology.org/Tumors/PilomatricomaID5153.html, https://orcid.org/0000-0003-3691-0324]
synonym: "calcifying epithelioma" RELATED []
synonym: "calcifying epithelioma of Malherbe" RELATED []
synonym: "epithelioma of Malherbe" RELATED []
synonym: "pilomatrixoma" RELATED []
synonym: "trichomatricoma" RELATED []
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0002014
name: increased papilloma incidence
def: "greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells occurring in a specific population in a given time period" [MPATH:445]
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0002015
name: epithelioid cyst
def: "presence of one or more abnormal membranous sacs in an epithelium" [J:51296]
synonym: "epithelial cyst" EXACT []
synonym: "epithelial cysts" EXACT []
synonym: "epithelioid cysts" EXACT []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0002016
name: ovary cyst
def: "presence of one or more fluid-filled membranous sacs within the ovary" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "cystic ovaries" EXACT []
synonym: "cystic ovary" EXACT []
synonym: "ovarian cyst" EXACT []
synonym: "ovarian cysts" EXACT []
synonym: "ovary cysts" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0002018
name: increased malignant tumor incidence
def: "higher than normal incidence of locally invasive, destructive and metastatic tumors" [ISBN:0-683-40008-8]
synonym: "increased malignant tumour incidence" EXACT []
synonym: "malignant tumors" RELATED []
synonym: "malignant tumours" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0002019
name: abnormal tumor incidence
def: "deviation from the expected number of abnormal growths in a specific population" [MGI:cwg]
synonym: "abnormal tumour incidence" EXACT []
is_a: MP:0002166 ! abnormal tumor susceptibility

[Term]
id: MP:0002020
name: increased tumor incidence
alt_id: MP:0002017
def: "greater than the expected number of neoplasms in a specific population in a given time period, usually of a specific type" [https://orcid.org/0000-0003-3691-0324, MESH:E05.318.308.985.525.375]
synonym: "increased neoplasm incidence" EXACT []
synonym: "increased tumour incidence" EXACT []
synonym: "spontaneous tumor" EXACT []
is_a: MP:0002019 ! abnormal tumor incidence

[Term]
id: MP:0002021
name: increased incidence of induced tumors
def: "higher than normal frequency of tumor incidence induced by a carcinogen, mutagen or virus" [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0003-3691-0324]
synonym: "increased incidence of induced tumours" EXACT []
is_a: MP:0002020 ! increased tumor incidence
is_a: MP:0013151 ! abnormal incidence of induced tumors

[Term]
id: MP:0002023
name: increased B cell derived lymphoma incidence
def: "higher than normal incidence of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MESH:C04.557.386.480.150]
synonym: "B cell derived lymphoma" RELATED []
synonym: "B-cell derived lymphoma" RELATED []
is_a: MP:0012431 ! increased lymphoma incidence

[Term]
id: MP:0002024
name: increased T cell derived lymphoma incidence
alt_id: MP:0003832
alt_id: MP:0005234
def: "higher than normal incidence of a group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MESH:C04.557.386.480.750]
synonym: "T cell derived lymphoma" RELATED []
synonym: "T-cell derived lymphoma" RELATED []
synonym: "thymic lymphoma" RELATED []
synonym: "thymic tumor" RELATED []
synonym: "thymic tumour" RELATED []
synonym: "thymus tumor" RELATED []
synonym: "thymus tumour" RELATED []
is_a: MP:0010365 ! increased thymus tumor incidence
is_a: MP:0012431 ! increased lymphoma incidence

[Term]
id: MP:0002025
name: obsolete B cell/T cell derived lymphoma
def: "OBSOLETE. group of heterogeneous lymphoid tumors representing malignant transformations of both B-lymphocytes and T-lymphocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "B-cell/T-cell derived lymphoma" EXACT []
is_obsolete: true

[Term]
id: MP:0002026
name: increased leukemia incidence
def: "higher than normal incidence of a cancer characterized by progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [DOID:1240, ISBN:0-683-40008-8]
synonym: "increased leucaemia incidence" EXACT []
synonym: "increased leukaemia incidence" EXACT []
synonym: "leucaemia" RELATED []
synonym: "leukaemia" RELATED []
synonym: "leukemia" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence

[Term]
id: MP:0002027
name: increased lung adenocarcinoma incidence
def: "greater than the expected number of a malignant neoplasm of epithelial cells in the lung, usually with a glandular organization, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "lung adenocarcinoma" RELATED []
is_a: MP:0008716 ! increased lung non-small cell carcinoma incidence
is_a: MP:0009308 ! increased adenocarcinoma incidence

[Term]
id: MP:0002030
name: increased neurofibrosarcoma incidence
alt_id: MP:0002034
def: "greater than the expected number of a highly aggressive malignant neoplasm arising from the fibrous connective tissue surrounding peripheral nerves, in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased fibroblastic neurosarcoma incidence" EXACT []
synonym: "malignant neurolemmoma" RELATED []
synonym: "malignant peripheral nerve sheath tumors" RELATED []
synonym: "malignant peripheral nerve sheath tumours" RELATED []
synonym: "MPNSTs" RELATED []
synonym: "peripheral nerve sheath tumor" RELATED []
synonym: "peripheral nerve sheath tumour" RELATED []
is_a: MP:0010281 ! increased nervous system tumor incidence
is_a: MP:0010363 ! increased fibrosarcoma incidence

[Term]
id: MP:0002031
name: increased adrenal gland tumor incidence
def: "greater than the expected number of neoplams in the adrenal gland occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased adrenal gland tumour incidence" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0002032
name: increased sarcoma incidence
def: "greater than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period" [DOID:1115, ISBN:0-683-40008-8]
synonym: "sarcoma" RELATED []
is_a: MP:0002018 ! increased malignant tumor incidence

[Term]
id: MP:0002033
name: increased malignant triton tumor incidence
def: "greater than the expected number of a malignant tumor with neurogenic and myogenic differentiation, occurring in a specific population in a given time period; usually arises in tissues of neural crest origin" [ISBN:0-683-40008-8]
synonym: "increased malignant triton tumour incidence" EXACT []
synonym: "malignant triton tumors" RELATED []
synonym: "malignant triton tumours" RELATED []
synonym: "MTTs" RELATED []
is_a: MP:0002018 ! increased malignant tumor incidence

[Term]
id: MP:0002035
name: increased leiomyosarcoma incidence
def: "greater than the expected number of a malignant tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "leiomyosarcoma" RELATED []
is_a: MP:0002032 ! increased sarcoma incidence
is_a: MP:0010290 ! increased muscle tumor incidence

[Term]
id: MP:0002036
name: increased rhabdomyosarcoma incidence
def: "greater than the expected number of a malignant tumor derived from skeletal (striated) muscle, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "rhabdomyosarcoma" RELATED []
is_a: MP:0002032 ! increased sarcoma incidence
is_a: MP:0010290 ! increased muscle tumor incidence

[Term]
id: MP:0002037
name: increased fibrohistocytoma incidence
def: "greater than the expected number of slowly growing skin nodules derived from cellular fibrous tissue occurring in a specific population in a given time period; these often surround capillaries" [ISBN:0-683-40008-8]
synonym: "dermatofibroma" RELATED []
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0002038
name: increased carcinoma incidence
def: "greater than the expected number of any of a variety of malignant neoplasms arising from epithelial cells, occurring in a specific population in a given time period; carcinomas are usually glandular or squamous in origin" [ISBN:0-683-40008-8]
synonym: "carcinoma" RELATED []
is_a: MP:0002018 ! increased malignant tumor incidence

[Term]
id: MP:0002039
name: increased neuroblastoma incidence
def: "greater than the expected number of a malignant neoplasm characterized by immature nerve cells of embryonic type, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "neuroblastoma" RELATED []
is_a: MP:0008021 ! increased blastoma incidence
is_a: MP:0010281 ! increased nervous system tumor incidence

[Term]
id: MP:0002041
name: increased pituitary adenoma incidence
def: "greater than the expected number of benign neoplasms of the pituitary, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
is_a: MP:0010320 ! increased pituitary gland tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0002042
name: obsolete hemotologic neoplasia
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002043
name: increased colon hamartoma incidence
def: "greater than the expected number of benign focal malformations in the colon in a specific population in a given time period; results from faulty colonic development, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [https://orcid.org/0000-0003-3691-0324]
synonym: "colon hamartoma" RELATED []
synonym: "colonic hamartoma" RELATED []
synonym: "increased colonic hamartoma incidence" EXACT []
is_a: MP:0010306 ! increased hamartoma incidence
is_a: MP:0012436 ! increased colon tumor incidence

[Term]
id: MP:0002044
name: increased colon adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the colon, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased colonic adenoma incidence" EXACT []
synonym: "increased colonic adenomata incidence" EXACT []
is_a: MP:0002404 ! increased intestinal adenoma incidence
is_a: MP:0012436 ! increased colon tumor incidence

[Term]
id: MP:0002045
name: increased renal cystadenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising in the kidney, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased kidney cystadenoma incidence" EXACT []
synonym: "increased kidney cystoma incidence" EXACT []
synonym: "increased renal cystoma incidence" EXACT []
is_a: MP:0010294 ! increased kidney tumor incidence
is_a: MP:0013751 ! increased cystadenoma incidence

[Term]
id: MP:0002047
name: increased hepatic hemangioma incidence
def: "greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the liver, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hepatic haemangioma" RELATED []
synonym: "hepatic hemangioma" RELATED []
synonym: "increased hepatic haemangioma incidence" EXACT []
synonym: "liver angioma" RELATED []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0008019 ! increased liver tumor incidence

[Term]
id: MP:0002048
name: increased lung adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
is_a: MP:0008014 ! increased lung tumor incidence
is_a: MP:0010383 ! increased adenoma incidence
is_a: MP:0020190 ! abnormal lung adenoma incidence

[Term]
id: MP:0002049
name: increased extremity angiosarcoma incidence
def: "higher than normal incidence of malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels" [ISBN:0-683-40008-8]
synonym: "extremity angiosarcoma" RELATED []
is_a: MP:0003667 ! increased hemangiosarcoma incidence

[Term]
id: MP:0002050
name: increased pheochromocytoma incidence
def: "greater than the expected number of a benign neoplasm derived from adrenal medullary cells, occurring in a specific population in a given time period; usually associated with hypertension" [ISBN:0-683-40008-8]
synonym: "increased phaeochromocytoma incidence" EXACT []
synonym: "phaeochromocytoma" RELATED []
synonym: "pheochromocytoma" RELATED []
is_a: MP:0002031 ! increased adrenal gland tumor incidence

[Term]
id: MP:0002051
name: increased skin papilloma incidence
def: "greater than the expected number of a circumscribed, benign epithelial tumor projecting from the surrounding surface, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "skin papilloma" RELATED []
is_a: MP:0002014 ! increased papilloma incidence
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0002052
name: decreased tumor incidence
alt_id: MP:0005514
def: "less than the expected number of neoplasms in a specific population in a given time period" [MESH:E05.318.308.985.525.375, MGI:cwg]
synonym: "decreased neoplasm incidence" EXACT []
synonym: "decreased susceptibility to neoplasm development" RELATED []
synonym: "decreased susceptibility to tumor development" RELATED []
synonym: "decreased susceptibility to tumour development" RELATED []
synonym: "decreased tumour incidence" EXACT []
synonym: "increased resistance to neoplasm development" EXACT []
synonym: "increased resistance to tumor development" EXACT []
synonym: "increased resistance to tumour development" EXACT []
synonym: "reduced tumor incidence" EXACT []
synonym: "reduced tumour incidence" EXACT []
is_a: MP:0002019 ! abnormal tumor incidence

[Term]
id: MP:0002053
name: decreased incidence of induced tumors
def: "reduced frequency of tumor incidence induced by a carcinogen, mutagen or virus" [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased incidence of induced tumours" EXACT []
synonym: "reduced incidence of induced tumors" EXACT []
synonym: "reduced incidence of induced tumours" EXACT []
is_a: MP:0002052 ! decreased tumor incidence
is_a: MP:0013151 ! abnormal incidence of induced tumors

[Term]
id: MP:0002054
name: obsolete disease states
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002055
name: obsolete Diabetes
def: "OBSOLETE. either insipidus or mellitus. Having in common the symptoms of polyuria" [ISBN:0-683-40008-8, MGI:cml]
comment: This is really a disease term; see OMIM for numerous types of this disease.
is_obsolete: true

[Term]
id: MP:0002056
name: obsolete Insulin dependent diabetes
def: "Obsolete. Characterized by polydipsia, polyuria, increased appetite, weight loss, low plasma insulin levels, and episodic ketoacidosis" [ISBN:0-683-40008-8, MGI:cml]
comment: This is really a disease term; see OMIM:222100.
synonym: "IDDM" EXACT []
synonym: "Juvenile diabetes" EXACT []
synonym: "Type I diabetes" EXACT []
is_obsolete: true

[Term]
id: MP:0002057
name: obsolete Non-insulin dependent diabetes
def: "OBSOLETE. Type II, adult onset. mild form gradual onset, usually in obese individuals. Plasma insulin levels are normal to high , but low in relation to plasma glucose levels. Responsive to dietary regulation or oral hypoglycemic agents, but diabetic complications and degenerative changes can develop" [ISBN:0-683-40008-8, MGI:cml]
comment: This is really a disease term; see OMIM:125853.
synonym: "NIDDM" EXACT []
synonym: "Type II, adult onset diabetes" EXACT []
is_obsolete: true

[Term]
id: MP:0002058
name: neonatal lethality
def: "death within the neonatal period after birth (Mus: P0)" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "neonatal death" EXACT []
is_a: MP:0002081 ! perinatal lethality

[Term]
id: MP:0002059
name: abnormal seminal vesicle morphology
alt_id: MP:0000656
def: "any structural anomaly of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; each sac is pyramidal in shape and convoluted in appearance and at the anterior extremity becomes constricted into a narrow straight duct that joins the ipsilateral vas deferens to form the ejaculatory duct; seminal vesicles secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal gonecyst morphology" EXACT []
synonym: "abnormal seminal gland morphology" EXACT []
synonym: "abnormal seminal vesicles morphology" EXACT []
synonym: "seminal gland dysplasia" NARROW []
synonym: "seminal vesicle dysplasia" NARROW []
is_a: MP:0009205 ! abnormal internal male genitalia morphology
is_a: MP:0013330 ! abnormal male accessory sex gland morphology

[Term]
id: MP:0002060
name: abnormal skin morphology
def: "any structural anomaly of the membranous protective covering of the body" [ISBN:0-683-40008-8, PMID:10469309]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal cutis morphology" EXACT []
synonym: "abnormal skin anatomy" EXACT []
synonym: "skin dysplasia" NARROW []
xref: Fyler:4133
is_a: MP:0010771 ! integument phenotype

[Term]
id: MP:0002061
name: abnormal aggression-related behavior
alt_id: MP:0001352
def: "domineering, assaultive or forceful physical action" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal aggression-related behaviour" EXACT []
synonym: "hostility related behavior" EXACT []
synonym: "hostility related behaviour" EXACT []
synonym: "neurological/behavioral: aggression" EXACT []
synonym: "neurological/behavioural: aggression" EXACT []
xref: MGI:2173566
is_a: MP:0002572 ! abnormal emotion/affect behavior

[Term]
id: MP:0002062
name: abnormal associative learning
def: "anomaly in the ability to change the frequency or form of a behavior as a result of the influence of the environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal conditioning behavior" EXACT []
synonym: "abnormal conditioning behaviour" EXACT []
synonym: "neurological/behavioral: conditioning defect" EXACT []
synonym: "neurological/behavioural: conditioning defect" EXACT []
xref: MGI:2173567
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0002063
name: abnormal learning/memory/conditioning
alt_id: MP:0001449
def: "altered ability to receive, store, process or recall informational stimuli" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal learning/ memory" EXACT []
synonym: "neurological/behavioral: learning/memory anomalies" EXACT []
synonym: "neurological/behavioral: learning/memory impairment" EXACT []
synonym: "neurological/behavioural: learning/memory anomalies" EXACT []
synonym: "neurological/behavioural: learning/memory impairment" EXACT []
xref: MGI:2173568
is_a: MP:0014114 ! abnormal cognition

[Term]
id: MP:0002064
name: seizures
alt_id: MP:0000946
alt_id: MP:0001493
def: "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: seizures/epilepsy" BROAD []
synonym: "neurological/behavioural: seizures/epilepsy" BROAD []
synonym: "seizures/epilepsy" BROAD []
xref: MGI:2173569
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002065
name: abnormal fear/anxiety-related behavior
def: "altered response in tests for fear or anxiety related behaviors" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal fear/anxiety behavior" EXACT []
synonym: "abnormal fear/anxiety behaviour" EXACT []
synonym: "abnormal fear/anxiety-related behaviour" EXACT []
synonym: "neurological/behavioral: fear/anxiety" EXACT []
synonym: "neurological/behavioural: fear/anxiety" EXACT []
xref: MGI:2173570
is_a: MP:0002572 ! abnormal emotion/affect behavior

[Term]
id: MP:0002066
name: abnormal motor capabilities/coordination/movement
def: "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: motor capabilities/coordination/movement anomalies" EXACT []
synonym: "neurological/behavioural: motor capabilities/coordination/movement anomalies" EXACT []
xref: MGI:2173571
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002067
name: abnormal sensory capabilities/reflexes/nociception
def: "inability or altered ability to respond to a sensory stimulus" [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: sensory capabilities/reflexes/nociception abnormalities" EXACT []
synonym: "neurological/behavioural: sensory capabilities/reflexes/nociception abnormalities" EXACT []
xref: MGI:2173572
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002068
name: abnormal parental behavior
def: "altered behavior of animals that affects the ability of offspring to survive" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal parental behaviour" EXACT []
synonym: "neurological/behavioral: parental behavior anomalies" EXACT []
synonym: "neurological/behavioural: parental behaviour anomalies" EXACT []
xref: MGI:2173573
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior

[Term]
id: MP:0002069
name: abnormal consumption behavior
def: "altered ability or inability to eat or drink, or unusual choice or avoidance of foods or drink" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal consumption behaviour" EXACT []
synonym: "abnormal eating/drinking behavior" EXACT []
synonym: "abnormal eating/drinking behaviour" EXACT []
synonym: "abnormal feeding/drinking behavior" EXACT []
synonym: "abnormal feeding/drinking behaviour" EXACT []
synonym: "neurological/behavioral: feeding/drinking anomalies" EXACT []
synonym: "neurological/behavioural: feeding/drinking anomalies" EXACT []
xref: MGI:2173574
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002070
name: obsolete abnormal sleep pattern/circadian rhythm
def: "OBSOLETE. deviation from the normal 24 hour biological activity cycle including the wake/sleep cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: sleep pattern/circadian rhythm anomalies" EXACT []
xref: MGI:2173575
is_obsolete: true
consider: MP:0001501

[Term]
id: MP:0002071
name: obsolete other abnormal behavior
def: "OBSOLETE. abnormal behaviors not attributable to other categories" [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: other anomalies" EXACT []
xref: MGI:2173576
is_obsolete: true

[Term]
id: MP:0002072
name: obsolete neurological/behavioral: no defect detected
def: "OBSOLETE. no anomaly observed in neurological or behavioral tests" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173577
is_obsolete: true

[Term]
id: MP:0002073
name: abnormal hair growth
alt_id: MP:0000409
def: "any anomaly in the amount of hair or abnormal onset of hair growth cycle or development, or abnormal hair pattern" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "coat: hair growth defects" EXACT []
synonym: "hair growth abnormalities" EXACT []
xref: MGI:2173539
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0002074
name: abnormal hair texture
alt_id: MP:0002077
def: "irregular or unusual appearance of the structure of the hair" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "coat: hair texture defects" EXACT []
synonym: "hair texture abnormalities" EXACT []
xref: MGI:2173540
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0002075
name: abnormal coat/hair pigmentation
alt_id: MP:0000368
def: "irregular or unusual pigmentation of the hair" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal coat color" EXACT []
synonym: "abnormal coat colour" EXACT []
synonym: "abnormal hair pigmentation" EXACT []
synonym: "coat: color anomalies" EXACT []
synonym: "coat: colour anomalies" EXACT []
xref: MGI:2173541
is_a: MP:0001186 ! pigmentation phenotype
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0002076
name: obsolete abnormal hair follicle structure/orientation
def: "OBSOLETE. any structural anomaly or misalignment of the epidermis from which the hair shaft develops" [https://orcid.org/0000-0003-3691-0324]
synonym: "coat: hair follicle structure/orientation anomalies" EXACT []
xref: MGI:2173542
is_obsolete: true
consider: MP:0000377
consider: MP:0000383

[Term]
id: MP:0002078
name: abnormal glucose homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glucose metabolism" NARROW []
synonym: "metabolism: abnormal glucose homeostasis" EXACT []
xref: MGI:2173579
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0002079
name: increased circulating insulin level
def: "greater than normal levels of insulin in blood" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "hyperinsulinaemia" EXACT []
synonym: "hyperinsulinemia" EXACT []
synonym: "hyperinsulinism" EXACT []
is_a: MP:0001560 ! abnormal circulating insulin level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0002080
name: prenatal lethality
alt_id: MP:0001645
alt_id: MP:0001707
def: "death anytime between fertilization and birth (Mus: approximately E18.5)" [https://orcid.org/0000-0003-3691-0324]
comment: Note that the name of this term has previously been embryonic lethality. In many species, the terms prenatal lethality and embryonic lethality are used interchangeably. However, this is not technically correct and we have modified this ontology to define the prenatal period to include the embryonic stages distinctly from the fetal stages. The names embryonic lethality and embryonic death have been retained as a narrow synonyms to aid in searching for those species that may use these terms as synonyms.
subset: IMPC
subset: Sanger_Terms
synonym: "antenatal lethality" EXACT []
synonym: "embryonic death" NARROW []
synonym: "embryonic lethality" NARROW []
synonym: "survival: embryonic lethality" NARROW []
synonym: "survival: prenatal lethality" EXACT []
xref: MGI:2173525
is_a: MP:0010770 ! preweaning lethality

[Term]
id: MP:0002081
name: perinatal lethality
alt_id: MP:0001644
def: "death anytime within the perinatal period (Mus: E18.5 through postnatal day 1)" [https://orcid.org/0000-0003-3691-0324]
synonym: "perinatal death" EXACT []
synonym: "stillborn" RELATED []
synonym: "survival: perinatal lethality" EXACT []
xref: MGI:2173526
is_a: MP:0010832 ! lethality during fetal growth through weaning

[Term]
id: MP:0002082
name: postnatal lethality
alt_id: MP:0001643
def: "premature death anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "juvenile lethality" EXACT []
synonym: "postnatal death" EXACT []
synonym: "survival: postnatal lethality" EXACT []
xref: MGI:2173527
is_a: MP:0010832 ! lethality during fetal growth through weaning

[Term]
id: MP:0002083
name: premature death
alt_id: MP:0001642
alt_id: MP:0001646
alt_id: MP:0001662
def: "death after weaning age, but before the normal life span (Mus: after 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal survival/ lethality" EXACT []
synonym: "reduced life span" EXACT []
synonym: "reduced lifespan" EXACT []
synonym: "short life span" EXACT []
synonym: "shorter life span" EXACT []
synonym: "survival: premature death" EXACT []
xref: MGI:2173528
is_a: MP:0010769 ! abnormal survival

[Term]
id: MP:0002084
name: abnormal developmental patterning
alt_id: MP:0001702
def: "abnormal systematic arrangement of the developing body along an axis" [https://orcid.org/0000-0003-3691-0324]
synonym: "embryogenesis: developmental patterning abnormalities" EXACT []
xref: MGI:2173529
is_a: MP:0001672 ! abnormal embryo development

[Term]
id: MP:0002085
name: abnormal embryonic tissue morphology
alt_id: MP:0001673
def: "any structural anomaly of the embryonic tissue part of the whole embryo" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal embryogenesis" RELATED []
synonym: "embryogenesis: embryonic tissue dysmorphology" EXACT []
synonym: "embryonic tissue dysplasia" NARROW []
xref: MGI:2173530
is_a: MP:0014134 ! abnormal embryo morphology

[Term]
id: MP:0002086
name: abnormal extraembryonic tissue morphology
alt_id: MP:0001708
alt_id: MP:0001709
def: "any structural anomaly of the membranes involved with embryonic protection and nutrition" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal extraembryonic tissues morphology" EXACT []
synonym: "embryogenesis: extraembryonic tissue dysmorphology" EXACT []
synonym: "extraembryonic tissue dysplasia" NARROW []
xref: MGI:2173531
is_a: MP:0005380 ! embryo phenotype

[Term]
id: MP:0002087
name: obsolete embryogenesis: no defect detected
def: "OBSOLETE. no anomaly observed in examination of embryonic development" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173532
is_obsolete: true

[Term]
id: MP:0002088
name: abnormal embryonic growth/weight/body size
def: "limited or accelerated growth or development apparent during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)" [https://orcid.org/0000-0003-3691-0324]
synonym: "growth/weight/body size abnormality: embryonic" EXACT []
xref: MGI:2173533
is_a: MP:0004196 ! abnormal prenatal growth/weight/body size

[Term]
id: MP:0002089
name: abnormal postnatal growth/weight/body size
alt_id: MP:0001252
def: "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal trunk/ body shape" EXACT []
synonym: "growth/weight/body size abnormality: postnatal" EXACT []
synonym: "trunk/ body shape abnormalities" EXACT []
xref: GO:0040007
xref: GO:0040014
xref: MGI:2173534
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0002090
name: abnormal vision
alt_id: MP:0001991
alt_id: MP:0002000
def: "any anomaly in the ability to see" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal visual ability" EXACT []
synonym: "eye: visual abnormalities" EXACT []
synonym: "visual abnormalities" EXACT []
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0002091
name: obsolete eye: no defect detected
def: "OBSOLETE. no anomaly observed in examination of eye tissue" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173538
is_obsolete: true

[Term]
id: MP:0002092
name: abnormal eye morphology
alt_id: MP:0001285
alt_id: MP:0001294
alt_id: MP:0001295
alt_id: MP:0004104
def: "any structural anomaly of the spheroid organ and optic nerve that serves to detect light" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC_Prenatal
synonym: "abnormal eyes morphology" EXACT []
synonym: "abnormal ocular orb morphology" EXACT []
synonym: "eye abnormalities" BROAD []
synonym: "eye dysplasia" NARROW []
synonym: "eye malformation" NARROW []
synonym: "eye tissue abnormalities" BROAD []
synonym: "eye: dysmorphology" NARROW []
synonym: "ocular dysplasia" NARROW []
synonym: "ophthalmic malformation" NARROW []
synonym: "visual system abnormalities" BROAD []
synonym: "visual system defects" BROAD []
xref: Fyler:4863
xref: GO:0001654
xref: MGI:2173536
is_a: MP:0005391 ! vision/eye phenotype

[Term]
id: MP:0002093
name: obsolete abnormal cornea/lens morphology
def: "OBSOLETE. any dysmorphology or complete or partial opacity of the lens or cornea" [https://orcid.org/0000-0003-3691-0324]
synonym: "eye: corneal/lens defect" EXACT []
xref: MGI:2173537
is_obsolete: true
consider: MP:0001303
consider: MP:0001312

[Term]
id: MP:0002094
name: obsolete coat: no defect detected
def: "OBSOLETE. no anomaly observed in examination of coat" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173543
is_obsolete: true

[Term]
id: MP:0002095
name: abnormal skin pigmentation
alt_id: MP:0001187
def: "anomaly in the coloration of the skin due to changes in the amount, shape, or distribution of cells producing pigment" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cutaneous pigmentation" EXACT []
synonym: "skin: pigmentation anomalies" EXACT []
xref: MGI:2173544
is_a: MP:0001186 ! pigmentation phenotype
is_a: MP:0011239 ! abnormal skin coloration

[Term]
id: MP:0002096
name: obsolete abnormal skin condition/ morphology
alt_id: MP:0001185
def: "OBSOLETE. any structural anomaly or atypical condition of the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skin" EXACT []
synonym: "skin abnormalities" EXACT []
synonym: "skin: texture/condition anomalies" EXACT []
xref: MGI:2173545
is_obsolete: true
consider: MP:0001191
consider: MP:0002060

[Term]
id: MP:0002097
name: obsolete skin: no defect detected
def: "OBSOLETE. no anomaly observed in examination of skin" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173546
is_obsolete: true

[Term]
id: MP:0002098
name: abnormal vibrissa morphology
alt_id: MP:0001271
def: "any structural anomaly of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors" [https://orcid.org/0000-0003-3691-0324, MESH:A13.950]
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "abnormal contour hair morphology" EXACT []
synonym: "abnormal sinus hair morphology" EXACT []
synonym: "abnormal touch hair morphology" EXACT []
synonym: "abnormal vibrissae morphology" EXACT []
synonym: "abnormal whiskers morphology" RELATED []
synonym: "vibrissae abnormalities" BROAD []
synonym: "vibrissae defects" BROAD []
synonym: "vibrissae dysplasia" NARROW []
synonym: "vibrissae: dysmorphology" NARROW []
xref: MGI:2173547
is_a: MP:0010678 ! abnormal skin adnexa morphology

[Term]
id: MP:0002099
name: obsolete vibrissae: no defect detected
def: "OBSOLETE. no anomaly observed in examination of whiskers" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173548
is_obsolete: true

[Term]
id: MP:0002100
name: abnormal tooth morphology
alt_id: MP:0000115
alt_id: MP:0000123
def: "any anomaly in the size, shape or structure of the hard or soft tissues of the skeletal element within the mouth that is composed of dentine and used to procure or masticate food" [https://orcid.org/0000-0003-3691-0324, UBERON:0001091]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal teeth morphology" EXACT []
synonym: "abnormal tooth structure" EXACT []
synonym: "teeth abnormalities" BROAD []
synonym: "teeth: tooth dysmorphology" NARROW []
synonym: "tooth dysplasia" NARROW []
xref: MGI:2173553
is_a: MP:0000452 ! abnormal mouth morphology
is_a: MP:0030254 ! abnormal dental arch morphology

[Term]
id: MP:0002101
name: obsolete teeth: no defect detected
def: "OBSOLETE. no anomaly observed in examination of teeth" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173554
is_obsolete: true

[Term]
id: MP:0002102
name: abnormal ear morphology
alt_id: MP:0000014
alt_id: MP:0000016
def: "any structural anomaly of any of the structures involved in the ear or vestibular system" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal auditory/ vestibular system morphology" BROAD []
synonym: "abnormal ear development/ ear malformation" NARROW []
synonym: "auditory/ vestibular system abnormalities" EXACT []
synonym: "auditory/ vestibular system defects" EXACT []
synonym: "ear dysplasia" NARROW []
synonym: "ears: dysmorphology" NARROW []
xref: Fyler:4867
xref: GO:0042471
xref: MGI:2173556
is_a: MP:0005377 ! hearing/vestibular/ear phenotype

[Term]
id: MP:0002103
name: obsolete ears: no defect detected
def: "OBSOLETE. no anomaly observed in examination of auditory tissue or in hearing assessment" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173557
is_obsolete: true

[Term]
id: MP:0002106
name: abnormal muscle physiology
alt_id: MP:0002105
def: "any functional anomaly of the muscle, not due to an anatomical defect" [https://orcid.org/0000-0003-3691-0324]
synonym: "muscle physiology abnormalities" EXACT []
synonym: "musculature: physiological defects" EXACT []
xref: MGI:2173559
is_a: MP:0005369 ! muscle phenotype

[Term]
id: MP:0002107
name: obsolete musculature: no defect detected
def: "OBSOLETE. no anomaly observed in examination of muscle tissue or in physiological assessment" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173560
is_obsolete: true

[Term]
id: MP:0002108
name: abnormal muscle morphology
alt_id: MP:0000728
alt_id: MP:0000735
alt_id: MP:0000758
def: "any structural anomaly of the contractile tissue that produces movement in animals" [MESH:A02.633]
synonym: "abnormal musculature morphology" EXACT []
synonym: "muscle abnormalities" BROAD []
synonym: "muscle dysplasia" NARROW []
synonym: "musculature abnormalities" BROAD []
synonym: "musculature: muscle dysmorphology" EXACT []
xref: MGI:2173558
is_a: MP:0005369 ! muscle phenotype

[Term]
id: MP:0002109
name: abnormal limb morphology
alt_id: MP:0000546
def: "any structural anomaly of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "extremities: limb dysmorphology" EXACT []
synonym: "limb abnormalities" BROAD []
synonym: "limb dysplasia" NARROW []
xref: MGI:2173549
is_a: MP:0005371 ! limbs/digits/tail phenotype

[Term]
id: MP:0002110
name: abnormal digit morphology
alt_id: MP:0000560
def: "any structural anomaly of the fingers or toes" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal finger morphology" NARROW []
synonym: "abnormal toe morphology" NARROW []
synonym: "digit abnormalities" BROAD []
synonym: "digit dysplasia" NARROW []
synonym: "extremities: digit dysmorphology" EXACT []
xref: MGI:2173550
is_a: MP:0000572 ! abnormal autopod morphology

[Term]
id: MP:0002111
name: abnormal tail morphology
alt_id: MP:0000584
alt_id: MP:0005173
def: "any structural anomaly of the flexible elongated appendage located at the caudal end of the torso in many species; it is usually continuous with the vertebral column" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "abnormal tail structure" EXACT []
synonym: "extremities: tail dysmorphology" NARROW []
synonym: "tail abnormalities" BROAD []
synonym: "tail dysplasia" NARROW []
synonym: "tail structure abnormalities" EXACT []
xref: MGI:2173551
is_a: MP:0005371 ! limbs/digits/tail phenotype

[Term]
id: MP:0002112
name: obsolete extremities: no defect detected
def: "OBSOLETE. no anomaly observed in examination of extremities" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173552
is_obsolete: true

[Term]
id: MP:0002113
name: abnormal skeleton development
alt_id: MP:0000056
alt_id: MP:0001534
alt_id: MP:0001537
def: "any anomaly in the formation of bone tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal bone development" EXACT []
synonym: "abnormal bone formation/ structure" EXACT []
synonym: "abnormal skeletogenesis" EXACT []
synonym: "skeletal: osteogenesis/developmental anomalies" EXACT []
xref: MGI:2173561
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0002114
name: abnormal axial skeleton morphology
def: "any structural anomaly of the articulated bones of the cranium and vertebral column" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "axial skeletal dysplasia" NARROW []
synonym: "skeletal: axial defects" BROAD []
xref: MGI:2173562
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0002115
name: abnormal limb bone morphology
def: "any structural anomaly of the limb or autopod bones" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skeleton extremities morphology" EXACT []
synonym: "dysplastic skeletal extremities" EXACT []
synonym: "skeletal: extremities defects" EXACT []
xref: MGI:2173563
is_a: MP:0002109 ! abnormal limb morphology
is_a: MP:0009250 ! abnormal appendicular skeleton morphology

[Term]
id: MP:0002116
name: abnormal craniofacial bone morphology
alt_id: MP:0000072
def: "any structural anomaly of the cranial or facial bones" [https://orcid.org/0000-0003-3691-0324]
synonym: "cranial/facial bone dysplasia" NARROW []
synonym: "craniofacial bone defects" BROAD []
synonym: "craniofacial bone dysplasia" NARROW []
synonym: "skeletal: craniofacial defects" EXACT []
xref: MGI:2173564
is_a: MP:0000428 ! abnormal craniofacial morphology
is_a: MP:0002114 ! abnormal axial skeleton morphology

[Term]
id: MP:0002117
name: obsolete skeletal: no defect detected
def: "OBSOLETE. no anomaly observed in examination of bones and/or skeleton" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173565
is_obsolete: true

[Term]
id: MP:0002118
name: abnormal lipid homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "metabolism: abnormal lipid homeostasis" EXACT []
xref: MGI:2173578
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0002119
name: dipsosis
def: "excessive desire to drink, or to drink unusual fluids" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "dipsesis" EXACT []
is_a: MP:0001423 ! abnormal liquid preference

[Term]
id: MP:0002121
name: obsolete other metabolic defect
alt_id: MP:0002120
def: "OBSOLETE. altered chemical and physical processes of the body or of a tissue, not due to lipid or glucose chemistry" [https://orcid.org/0000-0003-3691-0324]
synonym: "metabolism: other metabolic defect" EXACT []
synonym: "metabolism: other metabolic defect measured by clinical chemistry" EXACT []
xref: MGI:2173580
xref: MGI:2173581
is_obsolete: true
consider: MP:0005266

[Term]
id: MP:0002122
name: obsolete metabolism: no defect detected
def: "OBSOLETE. no anomaly observed in examination of metabolic function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173582
is_obsolete: true

[Term]
id: MP:0002123
name: abnormal definitive hematopoiesis
alt_id: MP:0000236
alt_id: MP:0000241
alt_id: MP:0001600
alt_id: MP:0001604
alt_id: MP:0001605
alt_id: MP:0002402
def: "abnormal development of blood cells in the fetal and adult organism; in the fetus cells develop in the aorta, genital ridge and mesonephros region and later in the liver; in adults cells normally develop in the bone marrow and lymphatic tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal definitive haematopoiesis" EXACT []
synonym: "abnormal definitive haematosis" EXACT []
synonym: "abnormal definitive hematosis" EXACT []
synonym: "abnormal sanguification" EXACT []
synonym: "blood development abnormalities" EXACT []
xref: MGI:2173583
is_a: MP:0013693 ! abnormal hemopoiesis

[Term]
id: MP:0002126
name: obsolete hematology: no defect detected
def: "OBSOLETE. no anomaly observed in examination of hematological development or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173586
is_obsolete: true

[Term]
id: MP:0002127
name: abnormal cardiovascular system morphology
alt_id: MP:0000177
def: "any structural anomaly of the heart or vascular tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiovascular dysplasia" NARROW []
synonym: "cardiovascular system abnormalities" BROAD []
synonym: "cardiovascular system defects" BROAD []
synonym: "cardiovascular system dysplasia" NARROW []
synonym: "heart/cardiovascular system: dysmorphology" NARROW []
xref: MGI:2173587
is_a: MP:0005385 ! cardiovascular system phenotype

[Term]
id: MP:0002128
name: abnormal blood circulation
alt_id: MP:0000308
alt_id: MP:0001632
def: "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circulation" BROAD []
synonym: "heart/cardiovascular system: blood circulatory defects" EXACT []
xref: MGI:2173588
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0002131
name: obsolete heart/cardiovascular system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of heart or vascular tissue or in cardiovascular function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173591
is_obsolete: true

[Term]
id: MP:0002132
name: abnormal respiratory system morphology
alt_id: MP:0001174
def: "any structural anomaly of pulmonary tissues" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "pulmonary malformation" NARROW []
synonym: "respiratory system dysplasia" NARROW []
synonym: "respiratory system: dysmorphology" EXACT []
xref: Fyler:4235
xref: MGI:2173592
is_a: MP:0005388 ! respiratory system phenotype

[Term]
id: MP:0002133
name: abnormal respiratory system physiology
def: "any functional anomaly of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "respiratory system dysfunction" EXACT []
synonym: "respiratory system physiology abnormalities" EXACT []
synonym: "respiratory system: respiratory distress/failure/functional anomalies" EXACT []
xref: MGI:2173593
is_a: MP:0005388 ! respiratory system phenotype

[Term]
id: MP:0002134
name: obsolete respiratory system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of lung and other respiratory tissues" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173594
is_obsolete: true

[Term]
id: MP:0002135
name: abnormal kidney morphology
alt_id: MP:0000518
alt_id: MP:0003650
def: "any structural anomaly of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal renal morphology" EXACT []
synonym: "kidney dysplasia" NARROW []
synonym: "kidney/renal system: dysmorphology" NARROW []
synonym: "renal dysplasia" NARROW []
synonym: "renal malformation" NARROW []
xref: Fyler:4512
xref: MGI:2173595
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0002136
name: abnormal kidney physiology
def: "any functional anomaly and/or activity of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney function" EXACT []
synonym: "abnormal renal physiology" EXACT []
synonym: "decreased renal function" NARROW []
synonym: "impaired renal function" NARROW []
synonym: "kidney malfunction" EXACT []
synonym: "kidney/renal system: functional anomalies" EXACT []
synonym: "loss of renal function" NARROW []
synonym: "reduced renal function" NARROW []
synonym: "renal dysfunction" EXACT []
synonym: "renal functional abnormality" EXACT []
xref: MGI:2173596
is_a: MP:0005502 ! abnormal renal/urinary system physiology

[Term]
id: MP:0002137
name: obsolete kidney/renal system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of kidney and other renal tissues" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173597
is_obsolete: true

[Term]
id: MP:0002138
name: abnormal hepatobiliary system morphology
alt_id: MP:0002172
def: "any structural anomaly of any of the tissues of the liver or biliary system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal liver/biliary system morphology" EXACT []
synonym: "hepatic dysplasia" NARROW []
synonym: "hepatic system abnormalities" BROAD []
synonym: "hepatic system defects" BROAD []
synonym: "liver/biliary system dysplasia" NARROW []
synonym: "liver/hepatic system: dysmorphology" EXACT []
xref: MGI:2173598
is_a: MP:0005370 ! liver/biliary system phenotype

[Term]
id: MP:0002139
name: abnormal hepatobiliary system physiology
alt_id: MP:0002173
def: "any functional anomaly of the tissues of the liver or biliary system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic system physiology" NARROW []
synonym: "abnormal liver/biliary system physiology" EXACT []
synonym: "hepatic system physiology abnormalities" NARROW []
synonym: "liver/hepatic system: functional anomalies" EXACT []
xref: MGI:2173599
is_a: MP:0005370 ! liver/biliary system phenotype

[Term]
id: MP:0002140
name: obsolete liver/hepatic system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of liver or other hepatic tissues" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173600
is_obsolete: true

[Term]
id: MP:0002143
name: obsolete digestive system: no defect detected
def: "OBSOLETE. no anomaly obsesrved in the function of or in any region of the digestive system" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173603
is_obsolete: true

[Term]
id: MP:0002144
name: abnormal B cell differentiation
alt_id: MP:0001801
alt_id: MP:0001803
alt_id: MP:0002438
def: "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal B cell development" EXACT []
synonym: "abnormal B cell maturation" EXACT []
synonym: "abnormal B lymphocyte development" EXACT []
synonym: "abnormal B lymphocyte maturation" EXACT []
synonym: "abnormal B-cell development" EXACT []
synonym: "abnormal B-cell maturation" EXACT []
synonym: "abnormal lymphoid development/ B lymphocyte defects" BROAD []
synonym: "B cell abnormalities" BROAD []
synonym: "B lymphocyte abnormalities" BROAD []
synonym: "B-cell abnormalities" BROAD []
synonym: "immune system: lymphoid development/ B lymphocyte defects" BROAD []
xref: MGI:2173604
is_a: MP:0002401 ! abnormal lymphopoiesis
is_a: MP:0004939 ! abnormal B cell morphology

[Term]
id: MP:0002145
name: abnormal T cell differentiation
alt_id: MP:0001821
alt_id: MP:0001822
alt_id: MP:0002431
alt_id: MP:0002489
def: "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lymphoid development/ T lymphocyte defects" BROAD []
synonym: "abnormal T cell development" EXACT []
synonym: "abnormal T cell maturation" EXACT []
synonym: "abnormal T cell morphology/development" EXACT []
synonym: "abnormal T lymphocyte development" EXACT []
synonym: "abnormal T-cell development" EXACT []
synonym: "abnormal T-cell maturation" EXACT []
synonym: "abnormal thymocyte development" NARROW []
synonym: "immune system: lymphoid development/ T lymphocyte defects" BROAD []
xref: MGI:2173605
is_a: MP:0002401 ! abnormal lymphopoiesis
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0002146
name: obsolete immune system: other dysmorphology
def: "OBSOLETE. abnormal development of lymphocytes or lymphatic tissue (other than B or T lymphocytes) resulting in morphological abnormality" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173606
is_obsolete: true

[Term]
id: MP:0002147
name: obsolete immune system: immunodeficiency
def: "OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173607
is_obsolete: true

[Term]
id: MP:0002148
name: abnormal hypersensitivity reaction
def: "immune response that results in tissue injury" [https://orcid.org/0000-0003-3691-0324]
synonym: "immune system: hypersensitivity" EXACT []
synonym: "immunologically mediated tissue injury" EXACT []
xref: MGI:2173608
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0002149
name: obsolete immune system: other functional anomaly
def: "OBSOLETE. altered immune response not due to anatomical defect, immunodeficiency or hypersensitivity" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173609
is_obsolete: true

[Term]
id: MP:0002150
name: obsolete immune system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of immune system tissues or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173610
is_obsolete: true

[Term]
id: MP:0002151
name: abnormal neural tube morphology
alt_id: MP:0000922
def: "any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
subset: IMPC_Prenatal
synonym: "abnormal neural tube morphology/development" BROAD []
synonym: "central nervous system: neural tube defects" BROAD []
synonym: "neural tube defects" BROAD []
synonym: "neural tube dysplasia" NARROW []
xref: Fyler:4339
xref: MGI:2173611
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0002152
name: abnormal brain morphology
alt_id: MP:0000770
alt_id: MP:0000775
def: "any structural anomaly of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [http://cancerweb.ncl.ac.uk, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain structure" EXACT []
synonym: "brain abnormalities" BROAD []
synonym: "brain dysplasia" NARROW []
synonym: "brain structure abnormalities" EXACT []
synonym: "central nervous system: brain dysmorphology" NARROW []
xref: MGI:2173612
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002156
name: obsolete central nervous system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of central nervous system tissues or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173616
is_obsolete: true

[Term]
id: MP:0002159
name: obsolete peripheral nervous system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of peripheral nervous system tissues or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173619
is_obsolete: true

[Term]
id: MP:0002160
name: abnormal reproductive system morphology
alt_id: MP:0001114
alt_id: MP:0001115
def: "structural or developmental anomaly of any of the tissues involved in the reproductive system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal reproductive anatomy morphology" EXACT []
synonym: "abnormal reproductive system" BROAD []
synonym: "reproductive system abnormalities" BROAD []
synonym: "reproductive system defects" BROAD []
synonym: "reproductive system dysplasia" NARROW []
synonym: "reproductive system: dysmorphology" EXACT []
xref: MGI:2173620
is_a: MP:0005389 ! reproductive system phenotype

[Term]
id: MP:0002161
name: abnormal fertility/fecundity
alt_id: MP:0001920
def: "anomaly in the reproductive capability of an organism or population to produce live offspring" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal fecundity" EXACT []
synonym: "reproductive system: fertility/fecundity anomalies" EXACT []
xref: MGI:2173621
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0002162
name: obsolete reproductive system: no defect detected
def: "OBSOLETE. no anomaly observed in examination of reproductive system tissues or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173622
is_obsolete: true

[Term]
id: MP:0002163
name: abnormal gland morphology
alt_id: MP:0000594
def: "any structural anomaly of an organ that functions as a secretory or excretory organ" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glands morphology" EXACT []
synonym: "gland abnormalities" BROAD []
synonym: "glands: dysmorphology" NARROW []
synonym: "glandular dysplasia" NARROW []
xref: MGI:2173623
is_a: MP:0005379 ! endocrine/exocrine gland phenotype

[Term]
id: MP:0002164
name: abnormal gland physiology
alt_id: MP:0001733
alt_id: MP:0001738
alt_id: MP:0002692
def: "any functional anomaly of an organ that functions as a secretory or excretory organ" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal endocrine gland function" NARROW []
synonym: "abnormal endocrine system physiology" NARROW []
synonym: "abnormal gland function" EXACT []
synonym: "endocrine system physiology abnormalities" NARROW []
synonym: "gland function abnormalities" EXACT []
synonym: "glands: functional anomalies" EXACT []
xref: MGI:2173624
is_a: MP:0005379 ! endocrine/exocrine gland phenotype

[Term]
id: MP:0002165
name: obsolete glands: no defect detected
def: "OBSOLETE. no anomaly observed in examination of endocrine system tissues or function" [https://orcid.org/0000-0003-3691-0324]
xref: MGI:2173625
is_obsolete: true

[Term]
id: MP:0002166
name: abnormal tumor susceptibility
def: "greater than or less than the average number of tumors, usually a specific type, arising in a given organism when compared to controls" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal tumour susceptibility" EXACT []
synonym: "altered neoplastic susceptibility" BROAD []
synonym: "altered tumor resistance" EXACT []
synonym: "altered tumor susceptibility" EXACT []
synonym: "altered tumour resistance" EXACT []
synonym: "altered tumour susceptibility" EXACT []
synonym: "tumorigenesis: altered tumor susceptibility/resistance" EXACT []
synonym: "tumourigenesis: altered tumour susceptibility/resistance" EXACT []
xref: MGI:2173626
is_a: MP:0002006 ! neoplasm

[Term]
id: MP:0002167
name: obsolete unaffected tumor susceptibility/resistance
def: "OBSOLETE. average number of tumors in an organism compared to controls, usually referring to a specific tumor type" [https://orcid.org/0000-0003-3691-0324]
synonym: "tumorigenesis: no altered tumor susceptibility/resistance" EXACT []
xref: MGI:2173627
is_obsolete: true

[Term]
id: MP:0002168
name: obsolete other aberrant phenotype
def: "anomaly or dysmorphology not attributable to any other category" [https://orcid.org/0000-0003-3691-0324]
comment: Term was obsoleted becasue it is invalid
xref: MGI:2173628
is_obsolete: true

[Term]
id: MP:0002169
name: no abnormal phenotype detected
alt_id: MP:0005396
def: "normal viability, fertility, appearance and behavior; reported phenotype is indistinguishable from controls" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "fertile" RELATED []
synonym: "no phenotype: no defect detected" EXACT []
synonym: "normal" BROAD []
synonym: "viability" RELATED []
synonym: "viable" RELATED []
synonym: "wild type" EXACT []
synonym: "wild-type" EXACT []
xref: MGI:2173629
is_a: MP:0002873 ! normal phenotype

[Term]
id: MP:0002174
name: abnormal gastrulation movements
def: "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [https://orcid.org/0000-0003-3691-0324, J:52418]
xref: GO:0007669
is_a: MP:0001695 ! abnormal gastrulation

[Term]
id: MP:0002175
name: decreased brain weight
def: "lower than average weight of the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "low brain weight" EXACT []
synonym: "reduced brain weight" EXACT []
is_a: MP:0000774 ! decreased brain size
is_a: MP:0012775 ! abnormal brain weight

[Term]
id: MP:0002176
name: increased brain weight
def: "greater than average weight of the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "high brain weight" EXACT []
is_a: MP:0005238 ! increased brain size
is_a: MP:0012775 ! abnormal brain weight

[Term]
id: MP:0002177
name: abnormal outer ear morphology
def: "any structural anomaly of any components of the auricles or external acoustic meatus" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "abnormal pinna morphology" EXACT []
synonym: "dysplastic pinna" NARROW []
synonym: "outer ear dysplasia" NARROW []
is_a: MP:0000428 ! abnormal craniofacial morphology
is_a: MP:0000432 ! abnormal head morphology
is_a: MP:0002102 ! abnormal ear morphology

[Term]
id: MP:0002180
name: obsolete
alt_id: MP:0002178
alt_id: MP:0002179
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002181
name: obsolete abnormal brain cell morphology
def: "OBSOLETE. any structural anomaly of any or all brain cell types" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain cells" EXACT []
synonym: "brain cell abnormalities" EXACT []
is_obsolete: true
consider: MP:0004101

[Term]
id: MP:0002182
name: abnormal astrocyte morphology
def: "any structural anomaly of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord; astrocytes are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier; astrocytes regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury" [CL:0000127, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal astrocytes morphology" EXACT []
synonym: "abnormal astrocytic glia morphology" EXACT []
synonym: "abnormal astroglia morphology" EXACT []
synonym: "abnormal astroglial cell morphology" EXACT []
is_a: MP:0000952 ! abnormal CNS glial cell morphology

[Term]
id: MP:0002183
name: gliosis
def: "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003634 ! abnormal glial cell morphology

[Term]
id: MP:0002184
name: abnormal innervation
def: "the malformation, misprojection, abnormal fasciculation or abnormal refinement of the connection, of nerve fibers to a target" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal axonal projection" EXACT []
synonym: "abnormal neuronal projection" EXACT []
synonym: "innervation abnormalities" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002185
name: obsolete ectopia
alt_id: MP:0002186
def: "OBSOLETE. congenital positional anomaly or displacement of any part of the body or organ" [ISBN:0-683-40008-8]
synonym: "heterotopia" EXACT []
is_obsolete: true

[Term]
id: MP:0002187
name: abnormal fibula morphology
def: "any structural anomaly of the lateral and smaller bone of the lower limb" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "fibula dysplasia" NARROW []
is_a: MP:0003857 ! abnormal hindlimb zeugopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0002188
name: small heart
def: "reduced size of the heart relative to average" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased heart size" EXACT []
synonym: "reduced heart size" EXACT []
is_a: MP:0005406 ! abnormal heart size

[Term]
id: MP:0002189
name: abnormal myocardial trabeculae morphology
def: "any structural anomaly of the supporting bundles of muscular fibers lining the walls of the heart" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal myocardium trabecular layer morphology" EXACT []
synonym: "abnormal trabeculae morphology" BROAD []
is_a: MP:0005329 ! abnormal myocardium layer morphology

[Term]
id: MP:0002190
name: disorganized myocardium
def: "derangement of the patterned architecture of the myocardium" [ISBN:0-683-40008-8]
synonym: "disorganised myocardium" EXACT []
is_a: MP:0005329 ! abnormal myocardium layer morphology

[Term]
id: MP:0002191
name: abnormal artery morphology
def: "any structural anomaly of the blood vessels that carry blood away from the heart" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal arteries morpholgy" EXACT []
synonym: "arterial dysplasia" NARROW []
synonym: "artery dysplasia" NARROW []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0002192
name: hydrops fetalis
def: "an abnormal accumulation of serous fluid in fetal tissues" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "fetal edema" EXACT []
synonym: "fetal oedema" EXACT []
synonym: "foetal edema" EXACT []
synonym: "foetal oedema" EXACT []
synonym: "hydrops foetalis" EXACT []
is_a: MP:0001785 ! edema

[Term]
id: MP:0002193
name: minimal clonic seizures
def: "seizures involving rhythmic face and forelimb clonus including arm movement, and it may include rearing and falling and ventral flexion of the neck; a seizure is scored as minimal when it satisfies the minimal criteria up to or including ventral flexion, but does not include maximal tonic hindlimb extension" [https://orcid.org/0000-0003-3691-0324, MGI:wf]
is_a: MP:0001650 ! abnormal seizure response to electrical stimulation

[Term]
id: MP:0002194
name: maximal tonic hindlimb extension seizures
def: "seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees)" [https://orcid.org/0000-0003-3691-0324, MGI:wf]
synonym: "maximal tonic hind limb extension seizures" EXACT []
is_a: MP:0001650 ! abnormal seizure response to electrical stimulation

[Term]
id: MP:0002195
name: psychomotor seizures
def: "low frequency, tetanic stimulation used to evoke partial limbic seizures, with currents ranging from 8 mA to 20 mA, depending on the strain and gender; manifesting as rhythmic face movements and extensive forelimb clonus (e.g. shadow-boxing forelimb movements), dorsal flexion of the neck, rearing and falling, and/or transient wobbliness/ataxia; seizure lasts only 10-15 seconds and when antiepileptic drugs are present may last only a few seconds" [https://orcid.org/0000-0003-3691-0324, MGI:wf]
synonym: "partial limbic seizures" EXACT []
is_a: MP:0001650 ! abnormal seizure response to electrical stimulation

[Term]
id: MP:0002196
name: absent corpus callosum
def: "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "absence of corpus callosum" EXACT []
synonym: "acallosal" EXACT []
synonym: "agenesis of corpus callosum" EXACT []
synonym: "corpus callosum absent" EXACT []
synonym: "corpus callosum agenesis" EXACT []
xref: Fyler:4321
is_a: MP:0000780 ! abnormal corpus callosum morphology

[Term]
id: MP:0002199
name: abnormal brain commissure morphology
def: "any structural anomaly of any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal commissure" BROAD []
is_a: MP:0000778 ! abnormal nervous system tract morphology
is_a: MP:0008026 ! abnormal brain white matter morphology

[Term]
id: MP:0002200
name: abnormal brain ventricular system morphology
def: "any structural anomaly of the brain ventricles, their associated choroid plexuses or the intercommunicating channels that connect the ventricular system" [ISBN:0-683-40008-8]
synonym: "abnormal brain ventricle/choroid plexus" EXACT []
synonym: "abnormal brain ventricle/choroid plexus morphology" RELATED []
synonym: "abnormal choroid/ventricle" EXACT []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0002201
name: obsolete abnormal neurotransmitter receptor physiology
def: "OBSOLETE. aberrant function of cell surface receptors that bind signaling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells" [MGI:cwg]
synonym: "neurotransmitter receptor defects" EXACT []
is_obsolete: true

[Term]
id: MP:0002204
name: abnormal synaptic neurotransmitter level
def: "anomaly in the amount of endogenous signaling molecules in a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell" [GO:0007269, https://orcid.org/0000-0003-3691-0324]
synonym: "neurotransmitter abnormalities" BROAD []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0002205
name: obsolete neurotransmitter imbalance
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002206
name: abnormal CNS synaptic transmission
def: "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MESH:G04.335.880.850]
synonym: "abnormal CNS neurotransmission" EXACT []
synonym: "abnormal synaptic transmission" BROAD []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0002207
name: abnormal long-term potentiation
alt_id: MP:0001472
alt_id: MP:0001896
alt_id: MP:0001897
alt_id: MP:0002154
def: "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "abnormal long term potentiation" EXACT []
synonym: "abnormal LTP" EXACT []
synonym: "abnormal LTP: CA1 region" NARROW []
synonym: "abnormal LTP: CA3 region" NARROW []
synonym: "central nervous system: LTP anomalies" EXACT []
synonym: "long term potentiation abnormalities" EXACT []
xref: MGI:2173614
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002208
name: abnormal germ cell morphology
def: "any structural anomaly of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8]
is_a: MP:0001929 ! abnormal gametogenesis
is_a: MP:0009840 ! abnormal foam cell morphology

[Term]
id: MP:0002209
name: decreased germ cell number
def: "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "decreased number of germ cells" EXACT []
synonym: "germ cell depletion" EXACT []
synonym: "germ cell hypoplasia" EXACT []
synonym: "reduced germ cell number" EXACT []
synonym: "reduced number of germ cells" EXACT []
is_a: MP:0002208 ! abnormal germ cell morphology

[Term]
id: MP:0002210
name: abnormal sex determination
alt_id: MP:0001936
def: "anomaly of primary or secondary sexual development or characteristics" [MGI:cwg]
synonym: "abnormal sexual differentiation" EXACT []
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0002211
name: abnormal primary sex determination
def: "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "abnormal gonad development" EXACT []
is_a: MP:0002210 ! abnormal sex determination

[Term]
id: MP:0002212
name: abnormal secondary sex determination
def: "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [MGI:llw2]
is_a: MP:0002210 ! abnormal sex determination

[Term]
id: MP:0002213
name: true hermaphroditism
def: "the presence of both unequivocal ovarian tissue and testicular elements in the same individual regardless of karyotype; these two tissue types may be present in the same gonad (ovotestis) or may be present as separate ovaries and testis tissue elements in the same individual regardless of sex chromosome complement" [ISBN:0-683-40008-8, MGI:llw2]
is_a: MP:0002211 ! abnormal primary sex determination

[Term]
id: MP:0002214
name: streak gonad
def: "impairment of genital ridge development; aplasia of gonadal tissue which is sometimes replaced with functionless tissue" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "gonadal streak" EXACT []
is_a: MP:0002211 ! abnormal primary sex determination
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0002215
name: obsolete testicular feminization
def: "OBSOLETE. an XY animal displaying female sex characteristics, usually due to an X-linked mutation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "androgen insensitivity" EXACT []
is_obsolete: true

[Term]
id: MP:0002216
name: abnormal seminiferous tubule morphology
def: "any structural anomaly of the tubules in the testes where spermatogenesis occurs" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal seminiferous tubules morphology" EXACT []
synonym: "seminiferous tubule dysplasia" NARROW []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0002217
name: small lymph nodes
def: "lymph nodes of decreased size" [MGI:cwg]
synonym: "decreased lymph node size" EXACT []
synonym: "reduced lymph node size" EXACT []
is_a: MP:0000701 ! abnormal lymph node size

[Term]
id: MP:0002218
name: increased lymph node number
def: "greater than the normal number of lymph nodes" [MGI:cwg]
is_a: MP:0000700 ! abnormal lymph node number

[Term]
id: MP:0002219
name: decreased lymph node number
def: "fewer than the normal number of lymph nodes" [MGI:cwg]
synonym: "reduced lymph node number" EXACT []
is_a: MP:0000700 ! abnormal lymph node number

[Term]
id: MP:0002220
name: large lymphoid organs
def: "increased size of lymphatic tissues" [MGI:cwg]
synonym: "increased lymphoid organs size" EXACT []
is_a: MP:0002221 ! abnormal lymph organ size

[Term]
id: MP:0002221
name: abnormal lymph organ size
def: "change in the normal size of lymphatic tissues" [MGI:cwg]
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0002222
name: obsolete abnormal lymph organ cellularity
def: "OBSOLETE. change in the normal number of cells within a lymph organ" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002223
name: lymphoid hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lymphoid tissue, typically resulting in decreased size" [MGI:cwg]
synonym: "decreased lymphoid tissue cellularity" RELATED []
synonym: "hypoplastic lymphoid organ" EXACT []
synonym: "lymph organ hypoplasia" EXACT []
is_a: MP:0000687 ! small lymphoid organs

[Term]
id: MP:0002224
name: abnormal spleen size
def: "deviation from the normal spleen size" [MGI:cwg]
synonym: "abnormal splenic size" RELATED []
is_a: MP:0000689 ! abnormal spleen morphology
is_a: MP:0002221 ! abnormal lymph organ size

[Term]
id: MP:0002225
name: obsolete abnormal spleen cellularity
def: "OBSOLETE. anomaly in the cellular makeup of the spleen" [MGI:cwg]
synonym: "abnormal splenic cellularity" EXACT []
synonym: "spleen cellularity abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0002227
name: abnormal spleen capsule morphology
def: "any structural anomaly of the connective tissue that surrounds the spleen" [MGI:cwg]
synonym: "abnormal splenic capsule morphology" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0002228
name: abnormal spleen trabecular vein morphology
def: "any structural anomaly of one of the veins that feed the splenic vein" [ISBN:0-397-51047-0, MGI:cwg]
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0002229
name: neurodegeneration
def: "a retrogressive impairment of function or destruction of neural tissue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "neuronal degeneration" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002230
name: abnormal primitive streak formation
def: "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
is_a: MP:0002231 ! abnormal primitive streak morphology

[Term]
id: MP:0002231
name: abnormal primitive streak morphology
def: "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
synonym: "defective primitive streak" NARROW []
synonym: "primitive streak dysplasia" NARROW []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0002232
name: obsolete sensory capabilities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002233
name: abnormal nose morphology
def: "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system" [MESH:A01.456.505.733, MGI:cwg]
subset: CvDC_Terms
synonym: "nasal malformation" NARROW []
synonym: "nose dysplasia" NARROW []
xref: Fyler:4870
is_a: MP:0002132 ! abnormal respiratory system morphology
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0002234
name: abnormal pharynx morphology
def: "any structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:cwg]
synonym: "pharynx dysplasia" NARROW []
is_a: MP:0002132 ! abnormal respiratory system morphology

[Term]
id: MP:0002235
name: abnormal external nares morphology
def: "any structural anomaly of the anterior opening to the nasal cavity" [MGI:cwg]
synonym: "abnormal anterior nares morphology" EXACT []
synonym: "abnormal nostril morphology" EXACT []
synonym: "external nares dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology

[Term]
id: MP:0002236
name: abnormal internal nares morphology
def: "any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx" [MGI:cwg]
synonym: "abnormal choanae morphology" EXACT []
synonym: "abnormal posterior nares morphology" EXACT []
synonym: "internal nares dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology

[Term]
id: MP:0002237
name: abnormal nasal cavity morphology
def: "any structural anomaly of the cavity of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [MESH:A04.531.449, MGI:cwg]
synonym: "abnormal cavity of nose morphology" EXACT []
synonym: "abnormal cavity of olfactory apparatus morphology" EXACT []
synonym: "abnormal nasal canal morphology" EXACT []
synonym: "abnormal nasal conduit space morphology" EXACT []
synonym: "abnormal nasal fossa morphology" EXACT []
synonym: "abnormal olfactory cavity morphology" EXACT []
synonym: "abnormal olfactory chamber cavity morphology" EXACT []
synonym: "abnormal olfactory chamber morphology" EXACT []
is_a: MP:0002233 ! abnormal nose morphology

[Term]
id: MP:0002238
name: abnormal nasal mucosa morphology
alt_id: MP:0001112
def: "any structural anomaly of the mucous membrane that lines the nasal cavity" [MESH:A04.760.600, MGI:cwg]
synonym: "abnormal nasal mucous membrane" EXACT []
synonym: "nasal mucosa dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0002277 ! abnormal respiratory mucosa morphology

[Term]
id: MP:0002239
name: abnormal nasal septum morphology
def: "any structural anomaly of the dividing wall that runs down the midline of the nose separating the two nasal cavities, each of which ends in a nostril; it is formed by the septal nasal cartilage, parts of skull bones (ethmoid bone; vomer), and membranous parts" [http://www.medicinenet.com/script/main/art.asp?articlekey=13720, https://orcid.org/0000-0002-6490-7723, MESH:A04.531.591]
synonym: "nasal septum dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology

[Term]
id: MP:0002240
name: abnormal paranasal sinus morphology
def: "any structural anomaly of the paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity" [ISBN:0-683-40008-8]
synonym: "abnormal paranasal sinuses morphology" EXACT []
synonym: "paranasal sinus dysplasia" NARROW []
is_a: MP:0002132 ! abnormal respiratory system morphology
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0002241
name: abnormal laryngeal mucosa goblet cell morphology
def: "any structural anomaly of the epithelial cells lining the larynx, which produce mucins" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal goblet cells of the laryngeal mucosa morphology" EXACT []
is_a: MP:0002261 ! abnormal laryngeal mucosa morphology

[Term]
id: MP:0002242
name: abnormal olfactory mucosa morphology
def: "any structural anomaly of the portion of the nasal mucosa that contains the olfactory sensory endings" [MESH:A04.531.520.573, MGI:cwg]
is_a: MP:0002238 ! abnormal nasal mucosa morphology
is_a: MP:0005499 ! abnormal olfactory system morphology

[Term]
id: MP:0002243
name: abnormal vomeronasal organ morphology
def: "any structural anomaly of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system; the organ lies at the base the nasal cavity and is split into two, separated by the nasal septum" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, https://orcid.org/0000-0003-3691-0324]
comment: This organ is believed to function in sensing pheromones. While the structure has been thought to be absent from higher primate adults, some data suggests that a form may be present in adult humans.
synonym: "abnormal Jacobson organ morphology" EXACT []
synonym: "abnormal Jacobson's organ morphology" EXACT []
synonym: "abnormal organon vomeronasale morphology" EXACT []
synonym: "abnormal organum vomeronasale morphology" EXACT []
synonym: "abnormal VNO morphology" EXACT []
synonym: "vomeronasal organ dysplasia" NARROW []
is_a: MP:0000959 ! abnormal somatic sensory system morphology
is_a: MP:0002239 ! abnormal nasal septum morphology

[Term]
id: MP:0002244
name: abnormal turbinate morphology
def: "any structural anomaly of the small curved bones that extends horizontally along the lateral wall of the nasal passage" [ISBN:0-683-40008-8]
synonym: "abnormal nasal concha morphology" EXACT []
synonym: "abnormal turbinates morphology" EXACT []
synonym: "turbinate dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0002245
name: abnormal ethmoid sinus morphology
def: "any structural anomaly of the evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses" [ISBN:0-683-40008-8]
synonym: "abnormal ethmoid air cell morphology" EXACT []
synonym: "abnormal ethmoid cell morphology" EXACT []
synonym: "ethmoid sinus dysplasia" NARROW []
is_a: MP:0002240 ! abnormal paranasal sinus morphology

[Term]
id: MP:0002246
name: abnormal frontal sinus morphology
def: "any structural anomaly of the paired evaginations of the mucous membrane of the nasal cavity into the lower part of the squama of the frontal bones" [ISBN:0-683-40008-8]
synonym: "frontal sinus dysplasia" NARROW []
is_a: MP:0002240 ! abnormal paranasal sinus morphology

[Term]
id: MP:0002247
name: abnormal maxillary sinus morphology
def: "any structural anomaly of the largest of the paranasal sinuses, a paired pyramid-shaped air sinus located within the maxillary bone which drains via the maxillary ostium into the infundibulum, then through the hiatus semilunaris into the middle meatus of the nose" [ISBN:0-683-40008-8]
synonym: "abnormal antrum of Highmore morphology" EXACT []
synonym: "abnormal genyantrum morphology" EXACT []
synonym: "abnormal maxillary antra morphology" EXACT []
synonym: "abnormal maxillary antrum morphology" EXACT []
synonym: "maxillary sinus dysplasia" NARROW []
is_a: MP:0002240 ! abnormal paranasal sinus morphology

[Term]
id: MP:0002248
name: abnormal sphenoid sinus morphology
def: "any structural anomaly of the most posterior paranasal sinus located in the sphenoid bone near the optic nerve and the pituitary gland on the side of the skull; it drains into the sphenoethmoidal recess superior to the superior concha; the sinus is divided into right and left parts by a bony septum" [https://www.dartmouth.edu/~humananatomy/part_8/chapter_52.html, https://www.healthline.com/human-body-maps/sphenoid-sinus, ISBN:0-683-40008-8]
synonym: "abnormal sphenoidal sinus morphology" EXACT []
synonym: "sphenoid sinus dysplasia" NARROW []
is_a: MP:0002240 ! abnormal paranasal sinus morphology

[Term]
id: MP:0002249
name: abnormal larynx morphology
def: "any structural anomaly of the organ of voice production located between the pharynx and the trachea" [ISBN:0-683-40008-8]
synonym: "larynx dysplasia" NARROW []
is_a: MP:0002132 ! abnormal respiratory system morphology

[Term]
id: MP:0002250
name: abnormal hypopharynx morphology
def: "any structural anomaly in the portion of the pharynx that lies below the upper edge of the epiglottis and opens into the larynx and the esophagus" [MGI:cwg]
synonym: "hypopharynx dysplasia" NARROW []
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0002251
name: abnormal nasopharynx morphology
def: "any structural anomaly of the section of the pharynx that lies above the soft palate" [MGI:cwg]
synonym: "nasopharynx dysplasia" NARROW []
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0002252
name: abnormal oropharynx morphology
def: "any structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [MGI:cwg]
synonym: "oropharynx dysplasia" NARROW []
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0002253
name: abnormal pharyngeal muscle morphology
def: "any structural anomaly of any of the muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus" [MESH:A02.633.567.800, MGI:cwg]
synonym: "pharyngeal muscle dysplasia" NARROW []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0002254
name: reproductive system inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in any of the reproductive organs" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0002255
name: abnormal glottis morphology
def: "any structural anomaly of the vocal apparatus of the larynx, which includes the vocal cords and the opening between them" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "glottis dysplasia" NARROW []
is_a: MP:0002249 ! abnormal larynx morphology

[Term]
id: MP:0002256
name: abnormal laryngeal cartilage morphology
def: "any structural anomaly of the cartilaginous structures that support the larynx" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "laryngeal cartilage dysplasia" NARROW []
is_a: MP:0002249 ! abnormal larynx morphology
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0002257
name: abnormal arytenoid cartilage morphology
def: "any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal cartilago arytaenoidea morphology" EXACT []
synonym: "arytenoid cartilage dysplasia" NARROW []
is_a: MP:0002256 ! abnormal laryngeal cartilage morphology

[Term]
id: MP:0002258
name: abnormal cricoid cartilage morphology
def: "any structural anomaly of the most inferior of the laryngeal cartilages" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal cartilago cricoidea morphology" EXACT []
synonym: "cricoid cartilage dysplasia" NARROW []
is_a: MP:0002256 ! abnormal laryngeal cartilage morphology

[Term]
id: MP:0002260
name: abnormal thyroid cartilage morphology
def: "any structural anomaly of the largest of the laryngeal cartilages" [ISBN:0-397-51047-0, MGI:cwg]
comment: The thyroid cartilage consists of two fused plates; their point of fusion is the "Adam's apple".
synonym: "abnormal cartilago thyreoidea morphology" EXACT []
synonym: "thyroid cartilage dysplasia" NARROW []
is_a: MP:0002256 ! abnormal laryngeal cartilage morphology

[Term]
id: MP:0002261
name: abnormal laryngeal mucosa morphology
def: "any structural anomaly of the mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "laryngeal mucosa dysplasia" NARROW []
is_a: MP:0002249 ! abnormal larynx morphology
is_a: MP:0002277 ! abnormal respiratory mucosa morphology

[Term]
id: MP:0002262
name: abnormal nasal mucosa goblet cell morphology
def: "any structural anomaly of the cells lining the nasal epithelium that produce and secrete mucins" [MGI:cwg]
synonym: "abnormal goblet cells of the nasal mucosa morphology" EXACT []
synonym: "abnormal nasal mucous membrane" BROAD []
is_a: MP:0002238 ! abnormal nasal mucosa morphology

[Term]
id: MP:0002263
name: abnormal laryngeal muscle morphology
def: "any structural anomaly of the muscles associated with the larynx" [ISBN:0-397-51047-0, MESH:A02.633.567.500, MGI:cwg]
synonym: "abnormal laryngeal muscles morphology" EXACT []
synonym: "laryngeal muscle dysplasia" NARROW []
is_a: MP:0002249 ! abnormal larynx morphology
is_a: MP:0030427 ! abnormal neck muscle morphology

[Term]
id: MP:0002264
name: abnormal bronchus morphology
def: "any structural anomaly of the upper conducting airways of the lung; these airways arise from the terminus of the trachea" [ISBN:0-397-51047-0, MESH:A04.411.125, MGI:cwg]
synonym: "abnormal bronchal morphology" EXACT []
synonym: "abnormal bronchi morphology" EXACT []
synonym: "bronchal dysplasia" NARROW []
synonym: "bronchi dysplasia" NARROW []
synonym: "bronchus dysplasia" NARROW []
is_a: MP:0004391 ! abnormal respiratory conducting tube morphology

[Term]
id: MP:0002265
name: abnormal left major bronchus morphology
def: "any structural anomaly of the conducting airway leading to the left lobe of the lungs" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "left major bronchus dysplasia" NARROW []
is_a: MP:0002264 ! abnormal bronchus morphology

[Term]
id: MP:0002266
name: abnormal right major bronchus morphology
def: "any structural anomaly of the conducting airway leading to the right lobe of the lungs" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "right major bronchus dysplasia" NARROW []
is_a: MP:0002264 ! abnormal bronchus morphology

[Term]
id: MP:0002267
name: abnormal bronchiole morphology
def: "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal bronchioles morphology" EXACT []
synonym: "bronchiolar dysplasia" NARROW []
is_a: MP:0004391 ! abnormal respiratory conducting tube morphology

[Term]
id: MP:0002268
name: abnormal terminal bronchiole morphology
def: "any structural anomaly of the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal terminal bronchioles morphology" EXACT []
synonym: "terminal bronchiolar dysplasia" NARROW []
is_a: MP:0002267 ! abnormal bronchiole morphology

[Term]
id: MP:0002269
name: muscular atrophy
def: "acquired diminution of muscle tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "muscle atrophy" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0002270
name: abnormal pulmonary alveolus morphology
def: "any structural anomaly of the small sac-like dilations of the distal airspace of the lung; they are present along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles; gas exchange of oxygen and carbon dioxide between alveolar air and blood in the pulmonary capillaries takes place across the cell walls" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal alveoli" BROAD []
synonym: "abnormal pulmonary alveoli morphology" EXACT []
synonym: "abnormal respiratory alveoli morphology" EXACT []
synonym: "abnormal respiratory alveolus morphology" EXACT []
is_a: MP:0010911 ! abnormal pulmonary acinus morphology

[Term]
id: MP:0002271
name: abnormal pulmonary alveolar duct morphology
def: "any structural anomaly of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal alveolar ducts morphology" EXACT []
synonym: "abnormal respiratory alveolar duct morphology" EXACT []
synonym: "pulmonary alveolar duct dysplasia" NARROW []
is_a: MP:0010911 ! abnormal pulmonary acinus morphology

[Term]
id: MP:0002272
name: abnormal nervous system electrophysiology
alt_id: MP:0002677
def: "any functional anomaly of the nervous system as it relates to conduction of electrical impulses" [MGI:cwg]
synonym: "abnormal electrophysiology" BROAD []
synonym: "electrophysiology abnormalities" BROAD []
synonym: "PNS electrophysiology abnormalities" NARROW []
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0002273
name: abnormal pulmonary alveolus epithelial cell morphology
def: "any structural anomaly of the cells lining the alveoli" [MGI:cwg]
synonym: "abnormal alveolar epithelial cells morphology" EXACT []
synonym: "abnormal lung epithelial cells morphology" EXACT []
synonym: "abnormal pneumocyte morphology" EXACT []
synonym: "abnormal pneumonocyte morphology" EXACT []
synonym: "abnormal respiratory alveolar epithelial cell morphology" EXACT []
synonym: "abnormal respiratory alveolus epithelial cell morphology" EXACT []
is_a: MP:0010898 ! abnormal pulmonary alveolus epithelium morphology
is_a: MP:0010901 ! abnormal pulmonary alveolar parenchyma morphology

[Term]
id: MP:0002274
name: abnormal type I pneumocyte morphology
def: "any structural anomaly of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
synonym: "abnormal AT1 morphology" EXACT []
synonym: "abnormal ATI morphology" EXACT []
synonym: "abnormal lung type 1 cells morphology" EXACT []
synonym: "abnormal membranous pneumocytes morphology" EXACT []
synonym: "abnormal Pulmonary alveolar type I cell morphology" EXACT []
synonym: "abnormal small alveolar cells morphology" EXACT []
synonym: "abnormal squamous alveolar cell morphology" EXACT []
synonym: "abnormal squamous alveolar lining cell morphology" EXACT []
synonym: "abnormal type 1 alveolar epithelial cells morphology" EXACT []
synonym: "abnormal Type 1 pneumocyte morphology" EXACT []
synonym: "abnormal type I alveolar epithelial cells morphology" EXACT []
synonym: "abnormal type I cells morphology" EXACT []
synonym: "abnormal type I pneumocytes morphology" EXACT []
synonym: "abnormal type I pneumonocytes morphology" EXACT []
xref: CL:0002062
xref: FMA:62500
is_a: MP:0002273 ! abnormal pulmonary alveolus epithelial cell morphology

[Term]
id: MP:0002275
name: abnormal type II pneumocyte morphology
def: "any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [https://orcid.org/0000-0002-6490-7723, ISBN:0412046911, PMID:8540632]
synonym: "abnormal AT2 morphology" EXACT []
synonym: "abnormal ATII morphology" EXACT []
synonym: "abnormal Cuboidal type II cell morphology" EXACT []
synonym: "abnormal granular pneumocytes morphology" EXACT []
synonym: "abnormal Great alveolar cells morphology" EXACT []
synonym: "abnormal Lung type 2 cells morphology" EXACT []
synonym: "abnormal Lung type II cells morphology" EXACT []
synonym: "abnormal TII morphology" EXACT []
synonym: "abnormal type 2 alveolar epithelial cells morphology" EXACT []
synonym: "abnormal type 2 alveolocytes morphology" EXACT []
synonym: "abnormal type 2 pneumocyte morphology" EXACT []
synonym: "abnormal type II alveolar epithelial cells morphology" EXACT []
synonym: "abnormal type II alveolocytes morphology" EXACT []
synonym: "abnormal type II cells morphology" EXACT []
synonym: "abnormal type II pneumocytes morphology" EXACT []
synonym: "abnormal type II pneumonocytes morphology" EXACT []
xref: CL:0002063
xref: FMA:62501
is_a: MP:0002273 ! abnormal pulmonary alveolus epithelial cell morphology

[Term]
id: MP:0002276
name: abnormal lung interstitium morphology
def: "any structural anomaly of the connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin; it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:14635660]
synonym: "abnormal pulmonary interstitium morphology" EXACT []
synonym: "lung interstitium dysplasia" NARROW []
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0002277
name: abnormal respiratory mucosa morphology
def: "any structural anomaly of the mucous membrane lining the respiratory tract" [MESH:A04.760, MGI:cwg]
synonym: "abnormal respiratory mucosal morphology" EXACT []
synonym: "respiratory mucosal dysplasia" NARROW []
is_a: MP:0010942 ! abnormal respiratory epithelium morphology

[Term]
id: MP:0002278
name: obsolete abnormal respiratory muscle morphology
def: "OBSOLETE. structural anomaly of any of the muscles involved in breathing" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002279
name: abnormal diaphragm morphology
alt_id: MP:0000760
def: "any structural anomaly of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [ISBN:0-683-40008-8, MGI:cwg]
subset: IMPC_Prenatal
synonym: "diaphragm muscle dysplasia" NARROW []
is_a: MP:0003358 ! abnormal hypaxial muscle morphology

[Term]
id: MP:0002280
name: abnormal intercostal muscle morphology
def: "any structural anomaly of the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib" [https://orcid.org/0000-0003-3691-0324, MESH:A02.633.567.900.500]
synonym: "intercostal muscle dysplasia" NARROW []
is_a: MP:0003358 ! abnormal hypaxial muscle morphology

[Term]
id: MP:0002281
name: abnormal respiratory mucosa goblet cell morphology
def: "any structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:cwg]
is_a: MP:0002277 ! abnormal respiratory mucosa morphology

[Term]
id: MP:0002282
name: abnormal trachea morphology
def: "any structural anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MESH:A04.889, MGI:cwg]
synonym: "trachea dysplasia" NARROW []
is_a: MP:0002132 ! abnormal respiratory system morphology

[Term]
id: MP:0002283
name: obsolete hyaline cartilage abnormalities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
replaced_by: MP:0006429

[Term]
id: MP:0002284
name: abnormal tracheal smooth muscle morphology
def: "any structural anomaly of the smooth muscle lining the trachea" [ISBN:0-397-51047-0, MGI:cwg]
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0002285
name: abnormal tracheal ciliated epithelium morphology
def: "any structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [ISBN:0-397-51047-0, MGI:cwg]
is_a: MP:0002282 ! abnormal trachea morphology
is_a: MP:0010942 ! abnormal respiratory epithelium morphology

[Term]
id: MP:0002286
name: cryptorchism
def: "failure of one or both of the testes to descend into the scrotum around the time of birth" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abdominal testes" EXACT []
synonym: "absence of scrotal testes" EXACT []
synonym: "cryptorchidism" EXACT []
synonym: "undescended testes" EXACT []
xref: Fyler:4493
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0002287
name: obsolete reproductive system: fertility/fecundity characteristics
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002288
name: obsolete litter size
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002291
name: obsolete fecundity characteristics
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002292
name: abnormal gestational length
def: "anomaly in the usual duration of time between when a fertilized egg implants in the wall of the uterus and the birth of offspring" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0002293
name: long gestation period
def: "increase in the average duration of a pregnancy" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased gestation length" EXACT []
is_a: MP:0002292 ! abnormal gestational length

[Term]
id: MP:0002294
name: short gestation period
def: "decrease in the average duration of a pregnancy" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased gestation length" EXACT []
is_a: MP:0002292 ! abnormal gestational length

[Term]
id: MP:0002295
name: abnormal pulmonary circulation
alt_id: MP:0001941
def: "any anomaly in the circulation of blood through the lungs" [MESH:G09.330.582.163.770, MGI:cwg]
synonym: "abnormal respiratory circulation" EXACT []
synonym: "pulmonary circulation abnormalities" EXACT []
synonym: "respiratory circulation abnormalities" EXACT []
is_a: MP:0002128 ! abnormal blood circulation
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0002296
name: aspiration
def: "inspiration into the airways of fluid or any foreign material" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0002314 ! abnormal respiratory mechanics

[Term]
id: MP:0002297
name: abnormal forced expiratory flow rates
def: "anomaly in the rates of airflow during forced vital capacity determination" [MESH:E01.370.386.700.660.225, MGI:cwg]
comment: Do not confuse with forced expiratory volume, a test of pulmonary ventilation.
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002327 ! abnormal respiratory function

[Term]
id: MP:0002298
name: obsolete abnormal maximal expiratory flow rate
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002299
name: obsolete abnormal maximal expiratory flow-volume curve
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002300
name: obsolete abnormal maximal midexpiratory flow rate
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002301
name: obsolete abnormal peak expiratory flow rate
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002302
name: obsolete abnormal forced expiratory volume
def: "OBSOLETE. anomaly in the maximum amount of air that can be expelled in a given number of seconds during a forced vital capacity determination" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002303
name: obsolete abnormal maximal voluntary ventilation
def: "OBSOLETE. anomaly in the maximum amount of air that can be breathed in and blown out over a specified interval" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002304
name: abnormal total lung capacity
def: "anomaly in the volume of air contained in the lungs at the end of maximal inspiration" [MESH:G09.772.765.850]
is_a: MP:0001942 ! abnormal lung volume
is_a: MP:0002314 ! abnormal respiratory mechanics

[Term]
id: MP:0002305
name: obsolete abnormal closing volume
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002306
name: abnormal functional residual capacity
def: "anomaly in the volume of air remaining in the lungs at the end of a normal expiration" [MESH:G09.772.765.850.390, MGI:cwg]
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002307
name: obsolete abnormal expiratory reserve volume
def: "OBSOLETE. anomaly in the amount of the extra volume of air that can be expired with maximum effort beyond the level reached at the end of a normal expiration" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002308
name: abnormal residual volume
def: "anomaly in the volume of air remaining in the lungs at the end of maximal expiration" [MESH:G09.772.765.850.390.820, MGI:cwg]
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002309
name: abnormal vital capacity
def: "anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration" [MESH:G09.772.765.850.970, MGI:cwg]
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002310
name: decreased susceptibility to hepatic steatosis
def: "less likely than normal to develop hepatic steatosis" [MGI:cwg]
synonym: "decreased susceptibility to fatty liver development" EXACT []
synonym: "increased resistance to fatty liver development" EXACT []
synonym: "increased resistance to hepatic steatosis" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0002311
name: abnormal inspiratory capacity
def: "anomaly in the maximal volume of air that can be inspired after the end of a normal expiration" [MESH:E01.370.386.700.485.750.900.350, MGI:cwg]
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002312
name: abnormal inspiratory reserve volume
def: "anomaly in the extra volume of air that can be inspired with maximal effort after reaching the end of a normal inspiration" [MESH:G09.772.765.850.970.500.375, MGI:cwg]
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002313
name: abnormal tidal volume
def: "anomaly in the volume of air inspired or expired during each normal respiratory cycle" [MESH:G09.772.765.850.970.500.700, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002314
name: abnormal respiratory mechanics
def: "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MESH:G09.772.770.755.700, MGI:cwg]
is_a: MP:0001943 ! abnormal respiration

[Term]
id: MP:0002315
name: obsolete abnormal respiratory signs/symptoms
def: "OBSOLETE. manifestations of diseases of the respiratory tract" [MESH:C23.888.852, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002316
name: anoxia
def: "absence or almost complete absence of oxygen from inspired gases, in blood or tissues" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0001574 ! abnormal oxygen level

[Term]
id: MP:0002318
name: hypercapnia
def: "elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased partial CO2 level" EXACT []
is_a: MP:0003860 ! abnormal carbon dioxide level

[Term]
id: MP:0002319
name: hyperoxia
def: "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased partial O2 level" EXACT []
is_a: MP:0001574 ! abnormal oxygen level

[Term]
id: MP:0002320
name: hyperventilation
def: "a state in which there is a increased amount of air entering the pulmonary alveoli (increased alveolar ventilation), which causes an decrease in arterial carbon dioxide level" [http://www.dorlands.com/]
synonym: "increased alveolar ventilation" EXACT []
is_a: MP:0005575 ! increased pulmonary ventilation

[Term]
id: MP:0002321
name: hypoventilation
def: "a state in which there is a reduced amount of air entering the pulmonary alveoli (decreased alveolar ventilation), which causes an increase in arterial carbon dioxide level" [http://www.dorlands.com/]
synonym: "decreased alveolar ventilation" EXACT []
is_a: MP:0005576 ! decreased pulmonary ventilation

[Term]
id: MP:0002322
name: abnormal respiratory transport
def: "anomaly in the process of gas exchange" [MESH:G06.535.166.775, MGI:cwg]
is_a: MP:0001943 ! abnormal respiration

[Term]
id: MP:0002323
name: decreased susceptibility to hyperlipidemia
def: "less likely than normal to develop abnormally high levels of circulating lipids" [MGI:cwg]
synonym: "decreased susceptibility to hyperlipidaemia" EXACT []
synonym: "increased resistance to hyperlipidaemia" EXACT []
synonym: "increased resistance to hyperlipidemia" EXACT []
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0002324
name: abnormal alveolocapillary membrane morphology
def: "any structural anomaly of the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm" [MESH:A04.411.715.025, MGI:cwg]
synonym: "abnormal alveolar-capillary barrier morphology" EXACT []
synonym: "abnormal alveolar-capillary membrane morphology" EXACT []
synonym: "abnormal alveolocapillary barrier morphology" EXACT []
synonym: "abnormal blood-air barrier morphology" EXACT []
synonym: "abnormal blood-gas barrier morphology" EXACT []
is_a: MP:0010900 ! abnormal pulmonary interalveolar septum morphology

[Term]
id: MP:0002325
name: abnormal pulmonary diffusing capacity
def: "anomaly in the amount of gas taken up by pulmonary capillary blood per minute per unit of average oxygen pressure gradient between alveolar gas and pulmonary capillary blood" [MESH:G09.772.765.600, MGI:cwg]
is_a: MP:0002336 ! abnormal pulmonary gas exchange

[Term]
id: MP:0002326
name: abnormal ventilation-perfusion ratio
def: "anomaly in the ratio of alveolar ventilation to simultaneous capillary blood flow in the lung" [MESH:G09.772.765.920, MGI:cwg]
comment: Changes in the ventilation-perfusion ratio alter the amount of O2 or CO2 in the blood.
is_a: MP:0002295 ! abnormal pulmonary circulation
is_a: MP:0002336 ! abnormal pulmonary gas exchange
is_a: MP:0002338 ! abnormal pulmonary ventilation

[Term]
id: MP:0002327
name: abnormal respiratory function
def: "anomaly in any measure of the processes involved in respiration" [MGI:cwg]
is_a: MP:0001943 ! abnormal respiration

[Term]
id: MP:0002328
name: abnormal airway resistance
def: "anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MESH:E01.370.386.700.050, MGI:cwg]
is_a: MP:0002314 ! abnormal respiratory mechanics
is_a: MP:0002327 ! abnormal respiratory function

[Term]
id: MP:0002329
name: abnormal blood gas level
def: "anomaly in the amount of oxygen and carbon dioxide in the blood" [MESH:E01.450.150.100.100, MGI:cwg]
is_a: MP:0003948 ! abnormal gas homeostasis
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0002330
name: abnormal bronchial provocation
def: "anomaly in the results of measures of responsiveness to allergens, pharmacological solutions, or control solutions" [MESH:E01.370.386.700.125, MGI:cwg]
is_a: MP:0002327 ! abnormal respiratory function

[Term]
id: MP:0002332
name: abnormal exercise endurance
def: "improved or impaired performance during controlled physical activity" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal exercise fitness" EXACT []
synonym: "abnormal exercise tests" RELATED []
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0002333
name: abnormal lung compliance
def: "anomaly in the ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788X, MESH:E01.370.386.700.475]
comment: This is a measure of the stiffness of the lung and indicative for diseases that cause fibrosis or edema in the lungs.
synonym: "abnormal pulmonary compliance" EXACT []
is_a: MP:0002314 ! abnormal respiratory mechanics

[Term]
id: MP:0002334
name: abnormal airway responsiveness
alt_id: MP:0002331
def: "anomalous response in bronchial provocation tests" [MGI:cwg]
synonym: "abnormal methacholine challenge" NARROW []
is_a: MP:0002330 ! abnormal bronchial provocation

[Term]
id: MP:0002335
name: decreased airway responsiveness
def: "less easily provoked into bronchoconstriction during bronchial provocation testing" [MGI:cwg]
synonym: "airway hyporesponsiveness" EXACT []
synonym: "reduced airway responsiveness" EXACT []
is_a: MP:0002334 ! abnormal airway responsiveness

[Term]
id: MP:0002336
name: abnormal pulmonary gas exchange
def: "anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood" [MESH:G09.772.770.755.760.602, MGI:cwg]
is_a: MP:0002322 ! abnormal respiratory transport

[Term]
id: MP:0002337
name: abnormal whole-body plethysmography
def: "anomaly in the measurements gathered in a chamber that encloses the body and in which changes in volume are recorded" [ISBN:0-683-40008-8, MESH:E01.370.386.700.615, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001942 ! abnormal lung volume

[Term]
id: MP:0002338
name: abnormal pulmonary ventilation
def: "anomaly of the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: Do not confuse with pulmonary ventilation rate (aka respiratory rate). Pulmonary ventilation is the volume of air per minute; pulmonary ventilation rate is the number of breaths per minute.
synonym: "abnormal respiratory minute ventilation" RELATED []
synonym: "abnormal respiratory minute volume" EXACT []
is_a: MP:0002314 ! abnormal respiratory mechanics

[Term]
id: MP:0002339
name: abnormal lymph node morphology
alt_id: MP:0000699
alt_id: MP:0005024
def: "any structural anomaly of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue, and is the site where acquired immune responses are launched" [https://orcid.org/0000-0003-3691-0324, MESH:A10.549.400]
synonym: "abnormal lymph gland morphology" EXACT []
synonym: "abnormal lymph node structure" EXACT []
synonym: "lymph node abnormalities" BROAD []
synonym: "lymph node dysplasia" NARROW []
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0002340
name: abnormal axillary lymph node morphology
def: "any structural anomaly of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8]
synonym: "axillary lymph node abnormalities" EXACT []
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0002341
name: obsolete abnormal lymph node capsule
def: "OBSOLETE. anomaly in the connective tissue that surrounds a lymph node" [ISBN:0-397-51047-0, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002342
name: abnormal lymph node trabecula morphology
def: "any structural anomaly of the membranous processes on the internal surface of the lymph node capsule, consisting of connective tissue and muscle fibers" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal lymph node trabeculae morphology" EXACT []
synonym: "lymph node trabecula dysplasia" NARROW []
synonym: "lymph node trabeculae dysplasia" NARROW []
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0002343
name: abnormal lymph node cortex morphology
def: "any structural anomaly in the outer area of the lymph node that has B and T cell domains" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0002344
name: abnormal lymph node B cell domain morphology
def: "any structural anomaly of the part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers" [PMID:17067937]
synonym: "abnormal lymph node B cell dependent cortex morphology" EXACT []
synonym: "abnormal lymph node B-cell domain morphology" EXACT []
synonym: "abnormal nodular lymph node cortex morphology" EXACT []
is_a: MP:0002343 ! abnormal lymph node cortex morphology

[Term]
id: MP:0002345
name: abnormal lymph node primary follicle morphology
def: "any structural anomaly of an unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex" [ISBN:0716749475]
comment: Cells in the primary follicle consist of cohesive aggregates of small, normal-appearing lymphocytes.
is_a: MP:0002344 ! abnormal lymph node B cell domain morphology

[Term]
id: MP:0002346
name: abnormal lymph node secondary follicle morphology
def: "any structural anomaly of a lymph node primary follicle that has undergone antigenic challenge and is characterized by a ring of concentrically packed B lymphocytes surrounding a germinal center, which contains proliferating B cells, and a mantle area that contains nondividing B cells and some helper T cells with macrophages and follicular dendritic cells interspersed" [ISBN:0716749475]
is_a: MP:0002344 ! abnormal lymph node B cell domain morphology

[Term]
id: MP:0002347
name: abnormal lymph node T cell domain morphology
def: "any structural anomaly of the paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells; T lymphocytes proliferate in the paracortex and enlarge it but do not produce structures analogous to germinal centers" [PMID:17067937]
synonym: "abnormal lymph node deep cortex morphology" EXACT []
synonym: "abnormal lymph node T cell dependent paracortex morphology" EXACT []
synonym: "abnormal lymph node T-cell domain morphology" EXACT []
is_a: MP:0002343 ! abnormal lymph node cortex morphology

[Term]
id: MP:0002348
name: abnormal lymph node medulla morphology
def: "any structural anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "abnormal medullary sinus morphology" NARROW []
synonym: "lymph node medulla dysplasia" NARROW []
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0002349
name: abnormal afferent lymphatic vessel morphology
def: "any structural anomaly in the lymphatic tubes entering the lymph node" [MGI:cwg]
xref: MA:0000748
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0002350
name: abnormal efferent lymphatic vessel morphology
def: "any structural anomaly in the lymphatic tube exiting the lymph node" [MGI:cwg]
xref: MA:0000749
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0002351
name: abnormal cervical lymph node morphology
def: "any structural anomaly of the lymph nodes found near the neck and shoulders" [MGI:cwg]
synonym: "cervical lymph node dysplasia" NARROW []
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0002352
name: abnormal popliteal lymph node morphology
def: "any structural anomaly of the lymph nodes which drain the legs" [MGI:cwg]
synonym: "popliteal lymph node dysplasia" NARROW []
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0002353
name: abnormal inguinal lymph node morphology
def: "any structural anomaly of the lymph nodes located in the groin area" [MGI:cwg]
synonym: "inguinal lymph node dysplasia" NARROW []
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0002354
name: abnormal spleen trabecular artery morphology
def: "any structural anomaly of one of the branches of the splenic artery" [ISBN:0-397-51047-0, MGI:cwg]
is_a: MP:0000689 ! abnormal spleen morphology
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0002355
name: obsolete abnormal spleen venous sinus
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002356
name: abnormal spleen red pulp morphology
def: "any structural anomaly of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal splenic red pulp morphology" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0002357
name: abnormal spleen white pulp morphology
def: "any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [https://orcid.org/0000-0003-3691-0324]
comment: Note that there is no consensus in the literature about which compartments constitute the white pulp or the ramifications of the microvasculature. In addition, notable differences exist between humans and rodents. In this ontology, the marginal sinus and marginal zone have been included as part of the white pulp.
synonym: "abnormal splenic white pulp morphology" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0002358
name: abnormal spleen periarteriolar lymphoid sheath morphology
def: "any structural anomaly of the area of the spleen in which T cells surround the central arteriole" [ISBN:0-397-51047-0, ISBN:0-8153-1691-7, MGI:cwg]
synonym: "abnormal PALS morphology" EXACT []
synonym: "abnormal periarteriolar sheath morphology" EXACT []
synonym: "abnormal splenic periarteriolar lymphoid sheath morphology" EXACT []
synonym: "abnormal T cell domain of the splenic white pulp morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0002359
name: abnormal spleen germinal center morphology
def: "any structural anomaly of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "abnormal spleen follicle center morphology" EXACT []
synonym: "abnormal spleen follicle centre morphology" EXACT []
synonym: "abnormal spleen GC morphology" EXACT []
synonym: "abnormal spleen germinal centre morphology" EXACT []
synonym: "abnormal splenic germinal center morphology" EXACT []
synonym: "abnormal splenic germinal centre morphology" EXACT []
is_a: MP:0008472 ! abnormal spleen secondary B follicle morphology

[Term]
id: MP:0002360
name: abnormal spleen B cell corona morphology
def: "any structural anomaly of the area of the spleen secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes" [PMID:17495967]
synonym: "abnormal B cell domain of the spleen" BROAD []
synonym: "abnormal follicle mantle morphology" EXACT []
synonym: "abnormal lymphocytic corona" BROAD []
synonym: "abnormal mantle zone" EXACT []
synonym: "abnormal spleen B-cell corona morphology" EXACT []
synonym: "abnormal splenic B cell corona morphology" EXACT []
is_a: MP:0008472 ! abnormal spleen secondary B follicle morphology

[Term]
id: MP:0002361
name: abnormal spleen central arteriole morphology
def: "any structural anomaly of the blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein" [ISBN:0-8153-1691-7]
synonym: "abnormal CA morphology" EXACT []
synonym: "abnormal follicular arteriole morphology" EXACT []
synonym: "abnormal splenic central arteriole morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0002362
name: abnormal spleen marginal zone morphology
def: "any structural anomaly of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8]
comment: Note that there is no consensus in the literature about which compartments constitute the white pulp or the ramifications of the microvasculature. In addition, notable differences exist between humans and rodents. In this ontology, the marginal zone has been included as part of the white pulp.
synonym: "abnormal splenic marginal zone morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0002363
name: abnormal spleen marginal sinus morphology
def: "any structural anomaly of the border region surrounding the spleen B cell follicles and the periarteriolar lymphoid sheath (PALS) that separates it from the marginal zone that mediates lymphocyte entry into the white pulp from the blood" [PMID:11485909]
comment: Note that there is no consensus in the literature about which compartments constitute the white pulp or the ramifications of the microvasculature. In addition, notable differences exist between humans and rodents. In this ontology, the marginal sinus (which may not exist in human) has been included as part of the white pulp. The perifollicular zone, which is present in human and not rodents, may be the functional equivalent of the marginal sinus in rodents.
synonym: "abnormal splenic marginal sinus morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0002364
name: abnormal thymus size
def: "deviation from the normal size of the thymus" [MGI:cwg]
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0002221 ! abnormal lymph organ size

[Term]
id: MP:0002365
name: obsolete abnormal thymus cellularity
def: "OBSOLETE. anomaly in the cellular makeup of the thymus" [MGI:cwg]
synonym: "abnormal thymic cellularity" EXACT []
is_obsolete: true

[Term]
id: MP:0002367
name: abnormal thymus lobule morphology
def: "any structural anomaly of the basic structural unit of the thymus" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "thymus lobule dysplasia" NARROW []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0002368
name: abnormal thymus capsule morphology
def: "any structural anomaly of the fibrous connective tissue surrounding the thymus" [MGI:cwg]
synonym: "thymus capsule dysplasia" NARROW []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0002369
name: abnormal thymus subcapsular epithelium morphology
def: "any structural anomaly of the epithelial cells lining the capsule and trabeculae of the thymus" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "abnormal subcapsular epithelium of the thymus morphology" EXACT []
is_a: MP:0009544 ! abnormal thymus epithelium morphology

[Term]
id: MP:0002370
name: abnormal thymus trabecula morphology
def: "any structural anomaly of the thymic connective tissue which extends into the parenchyma" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal thymus trabeculae morphology" EXACT []
synonym: "thymus trabecula dysplasia" NARROW []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0002371
name: abnormal thymus cortex morphology
def: "any structural anomaly of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8]
comment: The thymic cortex contains immature thymocytes, cortical epithelial cells, and scattered macrophages.
synonym: "thymus cortex dysplasia" NARROW []
is_a: MP:0002367 ! abnormal thymus lobule morphology

[Term]
id: MP:0002373
name: obsolete abnormal macrophages in the thymus
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002374
name: obsolete abnormal thymus epithelial cells
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002375
name: abnormal thymus medulla morphology
def: "any structural anomaly of the inner area of thymus lobules" [ISBN:0-8153-1691-7, MGI:cwg]
comment: The thymic medulla contains mature thymocytes, medulla epithelial cells, macrophages and dendritic cells.
synonym: "thymus medulla dysplasia" NARROW []
is_a: MP:0002367 ! abnormal thymus lobule morphology

[Term]
id: MP:0002376
name: abnormal dendritic cell physiology
def: "any functional anomaly of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [J:85808, MESH:A11.066.270]
synonym: "abnormal dendritic cell function" EXACT []
synonym: "abnormal interdigitating reticular cell physiology" EXACT []
is_a: MP:0002452 ! abnormal professional antigen presenting cell physiology

[Term]
id: MP:0002377
name: abnormal mucosa-associated lymphoid tissue morphology
def: "any structural anomaly of the regional immune system associated with the mucosa" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "MALT abnormalities" BROAD []
synonym: "MALT dysplasia" NARROW []
synonym: "mucosa-associated lymphoid tissue abnormalities" BROAD []
synonym: "mucosa-associated lymphoid tissue dysplasia" NARROW []
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0002378
name: abnormal gut-associated lymphoid tissue morphology
def: "any structural anomaly of the regional immune system located in the gut" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "GALT abnormalities" BROAD []
synonym: "GALT dysplasia" NARROW []
synonym: "gut-associated lymphoid tissue abnormalities" BROAD []
synonym: "gut-associated lymphoid tissue dysplasia" NARROW []
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0002379
name: abnormal oropharyngeal lymphoid tissue morphology
def: "any structural anomaly of the circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils" [MGI:cwg]
synonym: "abnormal Waldeyer's ring morphology" EXACT []
synonym: "oropharyngeal lymphoid tissue dysplasia" NARROW []
is_a: MP:0002377 ! abnormal mucosa-associated lymphoid tissue morphology

[Term]
id: MP:0002380
name: abnormal palatine tonsil morphology
def: "any structural anomaly of either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx" [MGI:cwg]
synonym: "abnormal tonsil morphology" BROAD []
is_a: MP:0002379 ! abnormal oropharyngeal lymphoid tissue morphology

[Term]
id: MP:0002381
name: obsolete abnormal tonsil capsule
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002382
name: obsolete abnormal lymphatic nodules with germinal centers
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002383
name: obsolete abnormal tonsil crypts
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002384
name: abnormal nasopharyngeal tonsil morphology
def: "any structural anomaly of the lymph tissue in the roof and posterior wall of the nasopharynx" [MGI:cwg]
synonym: "abnormal adenoid morphology" EXACT []
synonym: "adenoid dysplasia" NARROW []
synonym: "nasopharyngeal tonsil dysplasia" NARROW []
is_a: MP:0002379 ! abnormal oropharyngeal lymphoid tissue morphology

[Term]
id: MP:0002385
name: abnormal lingual tonsillar tissue morphology
def: "any structural anomaly of the lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue" [MGI:cwg]
synonym: "lingual tonsillar tissue dysplasia" NARROW []
is_a: MP:0002379 ! abnormal oropharyngeal lymphoid tissue morphology

[Term]
id: MP:0002386
name: abnormal tubal tonsil morphology
def: "any structural anomaly of the lymph tissue associated with the pharyngeal opening of the auditory tube" [MGI:cwg]
is_a: MP:0002379 ! abnormal oropharyngeal lymphoid tissue morphology

[Term]
id: MP:0002387
name: obsolete abnormal prevalence of Peyer's patches
def: "OBSOLETE. deviation from the normal distribution and/or number of Peyer's patches" [MGI:cwg]
is_obsolete: true
consider: MP:0008131
consider: MP:0008134

[Term]
id: MP:0002388
name: abnormal Peyer's patch epithelium morphology
def: "any structural anomaly of the specialized epithelium of the Peyer's patch" [ISBN:0-8153-1691-7, MGI:cwg]
comment: Antigen normally enters the Peyer's patch via this specialized epithelium.
is_a: MP:0000488 ! abnormal intestinal epithelium morphology
is_a: MP:0000696 ! abnormal Peyer's patch morphology

[Term]
id: MP:0002389
name: abnormal Peyer's patch follicle morphology
def: "any structural anomaly of the area of the Peyer's patch normally occupied by B cells" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0000696 ! abnormal Peyer's patch morphology

[Term]
id: MP:0002390
name: obsolete abnormal Peyer's patch dome
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002391
name: abnormal Peyer's patch germinal center morphology
def: "any structural anomaly of the area of the Peyer's patch where B cells proliferate and differentiate into plasma cells" [ISBN:0-8153-1691-7, MGI:cwg]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "abnormal Peyer's patch germinal centre morphology" EXACT []
is_a: MP:0002389 ! abnormal Peyer's patch follicle morphology

[Term]
id: MP:0002392
name: abnormal Peyer's patch T cell area morphology
def: "any structural anomaly of the Peyer's patch area normally occupied by T lymphocytes" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002389 ! abnormal Peyer's patch follicle morphology

[Term]
id: MP:0002393
name: abnormal bronchus-associated lymphoid tissue morphology
def: "any structural anomaly of the regional immune system located near the bronchus" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "abnormal bronchial-associated lymphoid tissue morphology" EXACT []
synonym: "BALT abnormalities" BROAD []
synonym: "BALT dysplasia" NARROW []
synonym: "bronchial-associated lymphoid tissue abnormalities" BROAD []
synonym: "bronchus-associated lymphoid tissue abnormalities" BROAD []
is_a: MP:0002722 ! abnormal immune system organ morphology

[Term]
id: MP:0002394
name: obsolete absent thymocyte subset
def: "OBSOLETE. lack of a particular group of T cells" [MGI:cwg]
synonym: "absence of thymocyte subset" EXACT []
is_obsolete: true

[Term]
id: MP:0002395
name: obsolete hemolymphoid system abnormalities
def: "OBSOLETE. anomalies of the blood and blood-forming tissues or of the immune system and immune cell forming tissues" [MGI:cwg]
synonym: "hematolymphoid system abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0002396
name: abnormal hematopoietic system morphology/development
def: "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [MGI:cwg]
synonym: "abnormal blood morphology" EXACT []
synonym: "abnormal haematopoietic system morphology/development" EXACT []
synonym: "abnormal haemopoietic system morphology/development" EXACT []
synonym: "abnormal hemopoietic system morphology/development" EXACT []
synonym: "haematopoietic organ abnormalities" BROAD []
synonym: "haematopoietic system dysplasia" NARROW []
synonym: "hematopoietic organ abnormalities" BROAD []
synonym: "hematopoietic system dysplasia" NARROW []
is_a: MP:0005397 ! hematopoietic system phenotype

[Term]
id: MP:0002397
name: abnormal bone marrow morphology
def: "any structural anomaly of the soft tissue that fills the cavities of bones" [MGI:cwg]
comment: Note that this term refers to the contents of the bone marrow cavity, not to the structure of the cavity itself.
synonym: "bone marrow abnormalities" BROAD []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0002398
name: abnormal bone marrow cell morphology/development
def: "any structural anomaly of the cells found in the bone marrow" [MGI:cwg]
synonym: "bone marrow cell abnormalities" BROAD []
is_a: MP:0002396 ! abnormal hematopoietic system morphology/development

[Term]
id: MP:0002399
name: abnormal pluripotent precursor cell morphology
def: "any structural anomaly of the cells that give rise to most types of cells necessary for fetal development" [MESH:A11.872.700, MGI:cwg]
synonym: "pluripotent stem cell abnormalities" BROAD []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0002400
name: abnormal multipotent stem cell morphology
def: "any structural anomaly of the specialized cells that are committed to giving rise to cells with particular functions" [MESH:A11.872.590, MGI:cwg]
synonym: "multipotent stem cell abnormalities" BROAD []
is_a: MP:0002399 ! abnormal pluripotent precursor cell morphology

[Term]
id: MP:0002401
name: abnormal lymphopoiesis
alt_id: MP:0000310
alt_id: MP:0001640
alt_id: MP:0001880
alt_id: MP:0008110
def: "atypical formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MESH:G04.335.151.825.597.500]
synonym: "abnormal lymphocyte differentiation" EXACT []
synonym: "lymphopoiesis abnormalities" EXACT []
is_a: MP:0002619 ! abnormal lymphocyte morphology
is_a: MP:0005460 ! abnormal leukopoiesis

[Term]
id: MP:0002403
name: abnormal pre-B cell morphology
def: "any structural anomaly of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These cells express the mu heavy chain in both the cytoplasm and on the cell surface; in addition to the mu heavy chain, other cell surface markers include CD45R, MHC class II, CD19, CD20, CD38, and CD40.
synonym: "abnormal pre-B-cell morphology" EXACT []
is_a: MP:0004939 ! abnormal B cell morphology

[Term]
id: MP:0002404
name: increased intestinal adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-0371-1954]
synonym: "increased intestinal adenomata incidence" EXACT []
synonym: "increased intestine adenoma incidence" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0010279 ! increased gastrointestinal tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0002405
name: respiratory system inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0002406
name: increased susceptibility to infection
alt_id: MP:0002550
alt_id: MP:0003001
def: "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "decreased resistance to infection" EXACT []
synonym: "susceptibility to infection" BROAD []
is_a: MP:0001793 ! abnormal susceptibility to infection

[Term]
id: MP:0002407
name: abnormal double-negative T cell morphology
def: "any structural anomaly of the subset of T cells found in the thymus that express neither CD4 nor CD8" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes.
synonym: "abnormal double negative T cell morphology" EXACT []
synonym: "CD4-CD8- T cell abnormalities" EXACT []
synonym: "double-negative T cell abnormalities" EXACT []
synonym: "double-negative T-cell abnormalities" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation

[Term]
id: MP:0002408
name: abnormal double-positive T cell morphology
def: "any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These cells are precursors to mature T cells and are generally located in the thymus; during their development, the alpha and beta chains of the T cell receptor are rearranged and the TCR receptor can be expressed.
synonym: "abnormal double positive T cell morphology" EXACT []
synonym: "CD4+CD8+ T cell abnormalities" EXACT []
synonym: "double-positive T cell abnormalities" EXACT []
synonym: "double-positive T-cell abnormalities" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology

[Term]
id: MP:0002409
name: decreased susceptibility to infection
alt_id: MP:0002549
alt_id: MP:0003002
def: "reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "increased resistance to infection" EXACT []
synonym: "reduced susceptibility to infection" EXACT []
synonym: "resistance to infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection

[Term]
id: MP:0002410
name: decreased susceptibility to viral infection
def: "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [MGI:cwg]
synonym: "increased resistance to viral infection" EXACT []
synonym: "reduced susceptibility to viral infection" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0002411
name: decreased susceptibility to bacterial infection
def: "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "increased resistance to bacterial infection" EXACT []
synonym: "reduced susceptibility to bacterial infection" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0020186 ! abnormal susceptibility to bacterial infection

[Term]
id: MP:0002412
name: increased susceptibility to bacterial infection
def: "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased resistance to bacterial infection" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0020186 ! abnormal susceptibility to bacterial infection

[Term]
id: MP:0002413
name: abnormal megakaryocyte progenitor cell morphology
def: "any structural anomaly of the progenitor cells of the thrombocytic (platelet) line of cells" [MGI:cwg]
synonym: "abnormal CFU-Mk morphology" EXACT []
synonym: "abnormal colony forming unit megakaryocyte morphology" EXACT []
synonym: "abnormal megacaryoblast morphology" RELATED []
synonym: "abnormal megacaryocyte progenitor cell morphology" EXACT []
synonym: "abnormal megakaryoblast morphology" EXACT []
synonym: "abnormal megakaryoblast morphology/development" RELATED []
synonym: "abnormal promegacaryocyte morphology" EXACT []
synonym: "abnormal promegakaryocyte morphology" EXACT []
synonym: "megakaryoblast abnormalities" BROAD []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013658 ! abnormal myeloid cell morphology
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0002414
name: abnormal myeloblast morphology/development
def: "any structural anomaly of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [MGI:cwg]
synonym: "myeloblast abnormalities" BROAD []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development

[Term]
id: MP:0002415
name: abnormal neutrophil differentiation
def: "atypical production of or inability to produce the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MESH:A11.118.637.415.583, MGI:cwg]
synonym: "abnormal neutrophil development" EXACT []
is_a: MP:0002414 ! abnormal myeloblast morphology/development
is_a: MP:0005065 ! abnormal neutrophil morphology
is_a: MP:0008111 ! abnormal granulocyte differentiation

[Term]
id: MP:0002416
name: abnormal proerythroblast morphology
def: "any structural anomaly of the immature, nucleated erythrocyte precursors that give rise to reticulocytes and are derived from erythroid progenitor cells" [MESH:A11.148.378.590.249.200, MGI:cwg]
synonym: "abnormal proerythroblast morphology/development" EXACT []
synonym: "proerythroblast abnormalities" EXACT []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013659 ! abnormal erythroid lineage cell morphology

[Term]
id: MP:0002417
name: abnormal megakaryocyte morphology
def: "any structural anomaly of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm" [CL:0000556, ISBN:0721601464]
synonym: "abnormal megacaryocyte morphology" EXACT []
synonym: "abnormal megalocaryocyte morphology" EXACT []
synonym: "abnormal megalokaryocyte morphology" EXACT []
synonym: "megakaryocyte abnormalities" EXACT []
is_a: MP:0013660 ! abnormal bone marrow hematopoietic cell morphology

[Term]
id: MP:0002418
name: increased susceptibility to viral infection
def: "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [MGI:cwg]
synonym: "decreased resistance to viral infection" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0002419
name: abnormal innate immunity
def: "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [ISBN:0-8153-1691-7]
synonym: "innate immunity dysfunction" EXACT []
synonym: "natural immunity abnormalities" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0002420
name: abnormal adaptive immunity
def: "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "acquired immune response dysfunction" EXACT []
synonym: "adaptive immunity dysfunction" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0002421
name: abnormal cell-mediated immunity
def: "abnormal function of any adaptive immune response in which T cells play a main role" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "cell-mediated immunity dysfunction" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0002422
name: abnormal basophil morphology
def: "any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation" [CL:0000767]
synonym: "basophil abnormalities" BROAD []
is_a: MP:0002414 ! abnormal myeloblast morphology/development
is_a: MP:0002441 ! abnormal granulocyte morphology

[Term]
id: MP:0002423
name: abnormal mast cell physiology
def: "any functional anomaly of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MESH:A11.329.427]
synonym: "abnormal mast cell function" EXACT []
synonym: "mast cell abnormalities" EXACT []
is_a: MP:0002462 ! abnormal granulocyte physiology

[Term]
id: MP:0002424
name: abnormal reticulocyte morphology
def: "any structural anomaly of immature erythrocytes characterized by a meshlike pattern of threads and particles at the former site of the nucleus" [ISBN:978-0-323-05290-0]
synonym: "abnormal immature erythrocyte morphology" EXACT []
synonym: "abnormal reticulocyte morphology/development" RELATED []
synonym: "reticulocyte abnormalities" BROAD []
is_a: MP:0013659 ! abnormal erythroid lineage cell morphology

[Term]
id: MP:0002425
name: abnormal susceptibility to autoimmune disorder
def: "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MESH:C20.111]
synonym: "abnormal autoimmune disorder susceptibility" EXACT []
synonym: "abnormal resistance to autoimmune disorder" EXACT []
synonym: "altered susceptibility to autoimmune disorder" EXACT []
synonym: "autoimmune disorders" EXACT []
is_a: MP:0001844 ! autoimmune response

[Term]
id: MP:0002426
name: obsolete blood abnormalities
def: "OBSOLETE. structural anomalies in the cells, fluids, or proteins found in the blood" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002427
name: disproportionate dwarf
def: "abnormally undersized with disproportionate body parts; usually with more significant shortening of the limbs in proportion to the trunk size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: In humans, dwarfism is defined as a condition in which the standing height of a person is below the third percentile.
synonym: "disproportionate dwarfism" EXACT []
is_a: MP:0001265 ! decreased body size

[Term]
id: MP:0002428
name: abnormal semicircular canal morphology
def: "any structural anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MESH:A09.246.631.663, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002729 ! abnormal inner ear canal morphology

[Term]
id: MP:0002429
name: abnormal blood cell morphology/development
alt_id: MP:0000178
alt_id: MP:0000205
alt_id: MP:0001576
alt_id: MP:0002545
def: "any structural anomaly of any of the cells found in the blood or hematopoietic organ" [MGI:cwg]
synonym: "blood cell abnormalities" EXACT []
synonym: "blood cell defects" EXACT []
is_a: MP:0002396 ! abnormal hematopoietic system morphology/development

[Term]
id: MP:0002432
name: abnormal CD4-positive, alpha beta T cell morphology
def: "any structural anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MESH:A11.118.637.555.567.569.200, MGI:cwg]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
synonym: "abnormal CD4+ T cell morphology" EXACT []
synonym: "abnormal CD4-positive T cell morphology" EXACT []
synonym: "abnormal single positive T cell morphology" BROAD []
synonym: "CD4+ T-cell abnormalities" EXACT []
is_a: MP:0002435 ! abnormal effector T cell morphology
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology

[Term]
id: MP:0002433
name: abnormal T-helper 1 cell morphology
def: "any structural anomaly of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
synonym: "abnormal helper T cell type 1 morphology" EXACT []
synonym: "abnormal helper T lymphocyte type 1" EXACT []
synonym: "abnormal helper T-cell type 1" EXACT []
synonym: "abnormal helper T-lymphocyte type 1" EXACT []
synonym: "abnormal T helper 1 morphology" EXACT []
synonym: "abnormal TH1 cell" EXACT []
synonym: "T helper 1 abnormalities" EXACT []
synonym: "TH1 abnormalities" EXACT []
synonym: "Th1 abnormalities" EXACT []
is_a: MP:0010183 ! abnormal CD4-positive helper T cell morphology

[Term]
id: MP:0002434
name: abnormal T-helper 2 cell morphology
def: "any structural anomaly of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149]
synonym: "abnormal helper T cell type 2 morphology" EXACT []
synonym: "abnormal helper T lymphocyte type 2" EXACT []
synonym: "abnormal helper T-cell type 2" EXACT []
synonym: "abnormal helper T-lymphocyte type 2" EXACT []
synonym: "abnormal T helper 2 morphology" EXACT []
synonym: "abnormal TH2 cell" EXACT []
synonym: "T helper 2 abnormalities" EXACT []
synonym: "TH2 abnormalities" EXACT []
synonym: "Th2 abnormalities" EXACT []
is_a: MP:0010183 ! abnormal CD4-positive helper T cell morphology

[Term]
id: MP:0002435
name: abnormal effector T cell morphology
def: "any structural anomaly of a differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response" [CL:0000911]
synonym: "abnormal mature T cell morphology" RELATED []
synonym: "abnormal single positive T cell" RELATED []
synonym: "abnormal single-positive T cell" RELATED []
synonym: "effector T cell abnormalities" EXACT []
synonym: "effector T-cell abnormalities" EXACT []
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0002436
name: abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
def: "any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner" [ISBN:0781735149]
comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
synonym: "abnormal CD8-positive, alpha-beta cytotoxic T lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta cytotoxic T-cell morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta cytotoxic T-lymphocyte morphology" EXACT []
synonym: "abnormal CTL morphology" BROAD []
synonym: "abnormal cytotoxic T cell morphology" BROAD []
synonym: "abnormal cytotoxic T lymphocyte morphology" BROAD []
synonym: "abnormal cytotoxic T-cell morphology" BROAD []
synonym: "abnormal cytotoxic T-lymphocyte morphology" BROAD []
synonym: "cytotoxic T cell abnormalities" BROAD []
synonym: "cytotoxic T-cell abnormalities" BROAD []
xref: CL:0000794
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology

[Term]
id: MP:0002439
name: abnormal plasma cell morphology
def: "any structural anomaly of a terminally differentiated, post-mitotic, short-lived cell of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
comment: Plasma cells are terminally differentiated B cells and no longer respond to antigens or helper T cells. In addition, they no longer express surface Ig or surface MHC class II molecules, and they secrete antibody at high rates.
synonym: "abnormal plasmacyte morphology" EXACT []
synonym: "plasma cell abnormalities" EXACT []
is_a: MP:0004939 ! abnormal B cell morphology

[Term]
id: MP:0002440
name: abnormal memory B cell morphology
def: "any structural anomaly of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149]
synonym: "abnormal memory B lymphocyte" EXACT []
synonym: "abnormal memory B-cell" EXACT []
synonym: "abnormal memory-B lymphocyte" EXACT []
synonym: "memory B cell abnormalities" EXACT []
synonym: "memory B-cell abnormalities" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0002441
name: abnormal granulocyte morphology
def: "any structural anomaly of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MESH:A11.118.637.415, MGI:cwg]
synonym: "granulocyte abnormalities" BROAD []
is_a: MP:0008250 ! abnormal myeloid leukocyte morphology
is_a: MP:0013657 ! abnormal blood cell morphology

[Term]
id: MP:0002442
name: abnormal leukocyte physiology
def: "any functional anomaly of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes)" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal leucocyte physiology" EXACT []
synonym: "leucocyte dysfunction" EXACT []
synonym: "leukocyte dysfunction" EXACT []
is_a: MP:0001819 ! abnormal immune cell physiology
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002421 ! abnormal cell-mediated immunity
is_a: MP:0012382 ! abnormal blood cell physiology

[Term]
id: MP:0002443
name: abnormal eosinophil differentiation
def: "atypical production of or inability to produce the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions" [CL:0000771]
synonym: "abnormal eosinocyte differentiation" EXACT []
synonym: "abnormal eosinophil development" EXACT []
synonym: "abnormal eosinophilic leucocyte differentiation" EXACT []
synonym: "abnormal eosinophilic leukocyte differentiation" EXACT []
synonym: "abnormal polymorphonuclear leucocyte differentiation" EXACT []
synonym: "abnormal polymorphonuclear leukocyte differentiation" EXACT []
synonym: "eosinophil abnormalities" BROAD []
is_a: MP:0005061 ! abnormal eosinophil morphology
is_a: MP:0008111 ! abnormal granulocyte differentiation

[Term]
id: MP:0002444
name: abnormal T cell physiology
def: "any functional anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal T cell function" EXACT []
synonym: "abnormal T lymphocyte function" EXACT []
synonym: "t lymphocyte dysfunction" NARROW []
synonym: "T-cell dysfunction" NARROW []
is_a: MP:0003945 ! abnormal lymphocyte physiology

[Term]
id: MP:0002445
name: abnormal mononuclear cell differentiation
def: "atypical production of or inability to produce a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
synonym: "abnormal mononuclear leucocyte differentiation" EXACT []
synonym: "abnormal mononuclear leukocyte differentiation" EXACT []
synonym: "mononuclear leucocyte development abnormalities" EXACT []
synonym: "mononuclear leukocyte development abnormalities" EXACT []
is_a: MP:0002414 ! abnormal myeloblast morphology/development
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0005460 ! abnormal leukopoiesis

[Term]
id: MP:0002446
name: abnormal macrophage morphology
def: "any structural anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, https://orcid.org/0000-0003-3691-0324]
synonym: "macrophage abnormalities" BROAD []
synonym: "mononuclear phagocyte abnormalities" BROAD []
is_a: MP:0008195 ! abnormal professional antigen presenting cell morphology
is_a: MP:0008248 ! abnormal mononuclear phagocyte morphology

[Term]
id: MP:0002447
name: abnormal erythrocyte morphology
alt_id: MP:0002124
def: "any structural anomaly of a mature red blood cell, an ennucleate biconcave disk about 7 micrometers in diameter that contains hemoglobin confined within a lipid membrane; it is the major cellular element of the circulating blood and transports oxygen as its principal function" [ISBN:978-0-323-05290-0]
synonym: "abnormal definitive erythrocyte" NARROW []
synonym: "abnormal red blood cell morphology" EXACT []
synonym: "abnormal red corpuscle morphology" EXACT []
synonym: "erythrocyte abnormalities" BROAD []
synonym: "red blood cell abnormalities" BROAD []
xref: MGI:2173584
is_a: MP:0013657 ! abnormal blood cell morphology
is_a: MP:0013659 ! abnormal erythroid lineage cell morphology

[Term]
id: MP:0002450
name: abnormal lymph organ development
def: "anomaly in the process of morphological maturation of the organs of the lymph system" [MGI:cwg]
synonym: "lymph organ developmental abnormalities" EXACT []
is_a: MP:0002722 ! abnormal immune system organ morphology
is_a: MP:0020981 ! abnormal immune system development

[Term]
id: MP:0002451
name: abnormal macrophage physiology
def: "any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, https://orcid.org/0000-0003-3691-0324]
synonym: "macrophage dysfunction" EXACT []
is_a: MP:0002419 ! abnormal innate immunity
is_a: MP:0002442 ! abnormal leukocyte physiology
is_a: MP:0002452 ! abnormal professional antigen presenting cell physiology

[Term]
id: MP:0002452
name: abnormal professional antigen presenting cell physiology
def: "any functional anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response" [CL:0000145, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal antigen presenting cell physiology" RELATED []
synonym: "antigen presenting cell dysfunction" EXACT []
is_a: MP:0001819 ! abnormal immune cell physiology
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002421 ! abnormal cell-mediated immunity

[Term]
id: MP:0002453
name: abnormal B lymphocyte antigen presentation
def: "anomaly in the ability of B lymphocyte to process and/or present antigen" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "B cell antigen presentation abnormalities" EXACT []
synonym: "lymphocyte antigen presentation dysfunction" EXACT []
is_a: MP:0001835 ! abnormal antigen presentation
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0002454
name: abnormal macrophage antigen presentation
def: "anomaly in the ability of macrophage phagocytic cells to process and present antigen to T lymphocytes" [ISBN:0-8153-1691-7]
synonym: "macrophage antigen presentation dysfunction" EXACT []
is_a: MP:0001835 ! abnormal antigen presentation
is_a: MP:0002451 ! abnormal macrophage physiology

[Term]
id: MP:0002455
name: abnormal dendritic cell antigen presentation
def: "anomaly in the ability of dendritic cells to process and present antigen to T lymphocytes" [ISBN:0-8153-1691-7]
synonym: "dendritic cell antigen presentation dysfunction" EXACT []
is_a: MP:0001835 ! abnormal antigen presentation
is_a: MP:0002376 ! abnormal dendritic cell physiology

[Term]
id: MP:0002456
name: abnormal Langerhans cell antigen presentation
def: "anomaly in the ability of phagocytic cells of the epidermis to display antigen for recognition by T lymphocytes" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "interdigitating reticular cell antigen presentation dysfunction" EXACT []
synonym: "Langerhans cell antigen presentation dysfunction" EXACT []
is_a: MP:0002455 ! abnormal dendritic cell antigen presentation
is_a: MP:0005362 ! abnormal Langerhans cell physiology

[Term]
id: MP:0002458
name: abnormal B cell number
def: "deviation from the normal count of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal B lymphocyte number" EXACT []
synonym: "abnormal B-cell number" EXACT []
is_a: MP:0000717 ! abnormal lymphocyte cell number
is_a: MP:0004939 ! abnormal B cell morphology

[Term]
id: MP:0002459
name: abnormal B cell physiology
def: "any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "B cell dysfunction" EXACT []
synonym: "B lymphocyte dysfunction" EXACT []
synonym: "B lymphocyte functional anomalies" EXACT []
synonym: "B-cell dysfunction" EXACT []
is_a: MP:0002452 ! abnormal professional antigen presenting cell physiology
is_a: MP:0003945 ! abnormal lymphocyte physiology

[Term]
id: MP:0002460
name: decreased immunoglobulin level
alt_id: MP:0001814
def: "less than normal immunoglobulin level" [MGI:cwg]
synonym: "decreased immunoglobulin concentration" EXACT []
synonym: "decreased serum level of immunoglobulin" NARROW []
synonym: "hypogammaglobulinemia" EXACT [https://www.ncbi.nlm.nih.gov/books/NBK563134/]
synonym: "reduced immunoglobulin concentration" EXACT []
is_a: MP:0002490 ! abnormal immunoglobulin level

[Term]
id: MP:0002461
name: increased immunoglobulin level
alt_id: MP:0001811
def: "greater than normal immunoglobulin level" [MGI:cwg]
synonym: "hypergammaglobulinemia" EXACT [https://www.ncbi.nlm.nih.gov/books/NBK585137/]
synonym: "increased immunoglobulin concentration" EXACT []
synonym: "increased serum level of immunoglobulin" NARROW []
is_a: MP:0002490 ! abnormal immunoglobulin level

[Term]
id: MP:0002462
name: abnormal granulocyte physiology
def: "any functional anomaly of neutrophils, eosinophils, or basophils" [MGI:cwg]
synonym: "granulocyte dysfunction" EXACT []
is_a: MP:0002442 ! abnormal leukocyte physiology

[Term]
id: MP:0002463
name: abnormal neutrophil physiology
def: "abnormal function of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [ISBN:0721601464]
synonym: "abnormal neutrocyte physiology" EXACT []
synonym: "abnormal neutrophil leucocyte physiology" EXACT []
synonym: "abnormal neutrophil leukocyte physiology" EXACT []
synonym: "abnormal neutrophilic leucocyte physiology" EXACT []
synonym: "abnormal neutrophilic leukocyte physiology" EXACT []
synonym: "abnormal PMN physiology" BROAD []
synonym: "abnormal polymorphonuclear leucocyte physiology" BROAD []
synonym: "abnormal polymorphonuclear leukocyte physiology" BROAD []
synonym: "abnormal polymorphonuclear neutrophil physiology" BROAD []
synonym: "abnormal polynuclear neutrophilic leucocyte physiology" BROAD []
synonym: "abnormal polynuclear neutrophilic leukocyte physiology" BROAD []
synonym: "neutrophil dysfunction" EXACT []
is_a: MP:0002419 ! abnormal innate immunity
is_a: MP:0002462 ! abnormal granulocyte physiology

[Term]
id: MP:0002464
name: abnormal basophil physiology
def: "any functional anomaly of the leukocyte that contains granules that stain with basic dyes" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "basophil dysfunction" EXACT []
is_a: MP:0002462 ! abnormal granulocyte physiology

[Term]
id: MP:0002465
name: abnormal eosinophil physiology
def: "any functional anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions" [CL:0000771, ISBN:0721601464]
synonym: "abnormal eosinocyte physiology" EXACT []
synonym: "abnormal eosinophilic leucocyte physiology" EXACT []
synonym: "abnormal eosinophilic leukocyte physiology" EXACT []
synonym: "abnormal polymorphonuclear leucocyte physiology" BROAD []
synonym: "abnormal polymorphonuclear leukocyte physiology" BROAD []
synonym: "eosinophil dysfunction" EXACT []
is_a: MP:0002462 ! abnormal granulocyte physiology

[Term]
id: MP:0002467
name: impaired neutrophil phagocytosis
def: "reduced ability of neutrophils to internalize particulate matter" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002463 ! abnormal neutrophil physiology
is_a: MP:0008546 ! abnormal vesicle-mediated transport

[Term]
id: MP:0002468
name: obsolete abnormal complement physiology
def: "OBSOLETE. abnormal function of the set of plasma proteins that act together to attack extracellular pathogens" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "complement dysfunction" EXACT []
is_obsolete: true
consider: MP:0002471

[Term]
id: MP:0002469
name: obsolete abnormal C1 physiology
def: "OBSOLETE. abnormal function of the complement protein, C1" [MGI:cwg]
synonym: "C1 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002470
name: obsolete abnormal C2 physiology
def: "OBSOLETE. abnormal function of the complement protein, C2" [MGI:cwg]
synonym: "C2 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002471
name: abnormal complement pathway
def: "impaired ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes" [GO:0006956]
synonym: "abnormal complement activation" RELATED []
synonym: "abnormal complement cascade" RELATED []
synonym: "abnormal complement response" RELATED []
synonym: "complement cascade dysfunction" EXACT []
xref: GO:0006956
is_a: MP:0001800 ! abnormal humoral immune response
is_a: MP:0002419 ! abnormal innate immunity

[Term]
id: MP:0002472
name: impaired complement alternative pathway
def: "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002471 ! abnormal complement pathway

[Term]
id: MP:0002473
name: impaired complement classical pathway
def: "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [ISBN:0-8153-1691-7, MGI:cwg]
is_a: MP:0002471 ! abnormal complement pathway

[Term]
id: MP:0002474
name: obsolete abnormal C3 physiology
def: "OBSOLETE. abnormal function of the complement protein, C3" [MGI:cwg]
synonym: "C3 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002475
name: obsolete abnormal C4 physiology
def: "OBSOLETE. abnormal function of the complement protein, C4" [MGI:cwg]
synonym: "C4 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002476
name: obsolete abnormal C5 physiology
def: "OBSOLETE. abnormal function of the complement protein, C5" [MGI:cwg]
synonym: "C5 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002477
name: obsolete abnormal C6 physiology
def: "OBSOLETE. abnormal function of the complement protein, C6" [MGI:cwg]
synonym: "C6 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002478
name: obsolete abnormal C7 physiology
def: "OBSOLETE. abnormal function of the complement protein, C7" [MGI:cwg]
synonym: "C7 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002479
name: obsolete abnormal C8 physiology
def: "OBSOLETE. abnormal function of the complement protein, C8" [MGI:cwg]
synonym: "C8 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002480
name: obsolete abnormal C9 physiology
def: "OBSOLETE. abnormal function of the complement protein, C9" [MGI:cwg]
synonym: "C9 dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002481
name: obsolete abnormal factor B physiology
def: "OBSOLETE. abnormal function of the complement protein, factor B" [MGI:cwg]
synonym: "Bf abnormalities" EXACT []
synonym: "factor B dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002482
name: obsolete abnormal factor D physiology
def: "OBSOLETE. abnormal function of the complement protein, factor D" [MGI:cwg]
synonym: "factor D dysfunction" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002483
name: obsolete abnormal acute phase protein physiology
def: "OBSOLETE. functional anomaly in the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7]
synonym: "acute phase protein dysfunction" EXACT []
is_obsolete: true
consider: MP:0010211

[Term]
id: MP:0002484
name: obsolete abnormal C-reactive protein physiology
def: "OBSOLETE. anomaly in the function of this plasma protein that normally circulates in increased amounts during inflammation or after tissue damage" [MESH:D12.776.034.145]
synonym: "C-reactive protein dysfunction" EXACT []
is_obsolete: true
consider: MP:0010212

[Term]
id: MP:0002485
name: obsolete abnormal mannose-binding protein physiology
def: "OBSOLETE. an anomaly in the function of this acute phase protein that normally opsonizes pathogens bearing mannose on their surfaces and can activate the complement system" [ISBN:0-8153-1691-7]
synonym: "mannose-binding protein dysfunction" EXACT []
is_obsolete: true
consider: MP:0010211

[Term]
id: MP:0002486
name: obsolete abnormal serum amyloid protein physiology
def: "OBSOLETE. any functional anomaly in an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790]
synonym: "abnormal SAA protein physiology" RELATED []
synonym: "abnormal Serum Amyloid A Protein physiology" EXACT []
synonym: "serum amyloid protein dysfunction" EXACT []
is_obsolete: true
consider: MP:0010214

[Term]
id: MP:0002487
name: obsolete abnormal fibrinogen physiology
def: "OBSOLETE. an anomaly in the function of this coaguable protein in the blood plasma" [ISBN:0-683-40008-8]
synonym: "fibrinogen dysfunction" EXACT []
is_obsolete: true
consider: MP:0010213

[Term]
id: MP:0002488
name: obsolete abnormal phagocyte physiology
def: "OBSOLETE. anomaly in the ability of these cells to ingest and internalize particulate matter" [MGI:cwg]
synonym: "abnormal phagocytic cell physiology" EXACT []
synonym: "phagocytic cell dysfunction" EXACT []
is_obsolete: true

[Term]
id: MP:0002490
name: abnormal immunoglobulin level
alt_id: MP:0001810
def: "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [ISBN:0-683-40008-8, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal immunoglobulin concentration" EXACT []
synonym: "abnormal serum immunoglobulin concentration" NARROW []
synonym: "abnormal serum level of immunoglobulin" NARROW []
is_a: MP:0001800 ! abnormal humoral immune response
is_a: MP:0002459 ! abnormal B cell physiology
is_a: MP:0002723 ! abnormal immune serum protein physiology

[Term]
id: MP:0002491
name: decreased IgD level
def: "less than normal immunoglobulin class D level" [MGI:cwg]
synonym: "reduced IgD level" EXACT []
is_a: MP:0002460 ! decreased immunoglobulin level
is_a: MP:0020172 ! abnormal IgD level

[Term]
id: MP:0002492
name: decreased IgE level
def: "less than normal immunoglobulin class E level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "reduced IgE level" EXACT []
is_a: MP:0002460 ! decreased immunoglobulin level
is_a: MP:0020173 ! abnormal IgE level

[Term]
id: MP:0002493
name: increased IgG level
alt_id: MP:0001812
def: "greater than normal immunoglobulin class G level" [MGI:cwg]
synonym: "increased serum level of immunoglobulin G" NARROW []
is_a: MP:0002461 ! increased immunoglobulin level
is_a: MP:0020174 ! abnormal IgG level

[Term]
id: MP:0002494
name: increased IgM level
alt_id: MP:0001813
def: "greater than normal immunoglobulin class M level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased serum level of immunoglobulin M" NARROW []
is_a: MP:0002461 ! increased immunoglobulin level
is_a: MP:0020180 ! abnormal IgM level

[Term]
id: MP:0002495
name: increased IgA level
def: "greater than normal immunoglobulin class A level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002461 ! increased immunoglobulin level
is_a: MP:0020171 ! abnormal IgA level

[Term]
id: MP:0002496
name: increased IgD level
def: "greater than normal immunoglobulin class D level" [MGI:cwg]
is_a: MP:0002461 ! increased immunoglobulin level
is_a: MP:0020172 ! abnormal IgD level

[Term]
id: MP:0002497
name: increased IgE level
def: "greater than normal immunoglobulin class E level" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002461 ! increased immunoglobulin level
is_a: MP:0020173 ! abnormal IgE level

[Term]
id: MP:0002498
name: abnormal acute inflammation
def: "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response" [ISBN:0-397-51047-0, ISBN:0-8153-1691-7]
synonym: "acute inflammation" EXACT []
synonym: "leucocyte infiltration" EXACT []
synonym: "leukocyte infiltration" EXACT []
is_a: MP:0001845 ! abnormal inflammatory response

[Term]
id: MP:0002499
name: chronic inflammation
def: "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [ISBN:0-8153-1691-7]
comment: Characterized by presence of lymphocytes, plasma cells, and macrophages.
is_a: MP:0001845 ! abnormal inflammatory response

[Term]
id: MP:0002500
name: granulomatous inflammation
def: "chronic inflammation resulting from the failure of the acute inflammatory response and persistence of the injurious agent; characterized by a central area of macrophages, often fused into giant cells, and surrounded by T cells" [ISBN:0-397-51047-0, ISBN:0-8153-1691-7]
is_a: MP:0002499 ! chronic inflammation

[Term]
id: MP:0002501
name: obsolete abnormal inflammatory mediator physiology
def: "OBSOLETE. functional anomaly of any of the endogenous compounds that mediate the local accumulation of fluid, plasma proteins, and leukocytes at the site of injury, insult, or infection" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "inflammatory mediators" EXACT []
is_obsolete: true

[Term]
id: MP:0002502
name: obsolete abnormal vasoactive mediator physiology
def: "OBSOLETE. functional anomaly of any of the endogenous compounds that act on the vasculature" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002503
name: abnormal histamine physiology
def: "any functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0002504
name: obsolete abnormal serotonin physiology
def: "OBSOLETE. functional anomaly of this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets; it normally mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8]
synonym: "abnormal 5-HT physiology" EXACT []
is_obsolete: true
consider: MP:0005322

[Term]
id: MP:0002505
name: obsolete abnormal bradykinin physiology
def: "OBSOLETE. functional anomaly of this potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability" [ISBN:0-397-51047-0]
is_obsolete: true
consider: MP:0009812

[Term]
id: MP:0002506
name: obsolete abnormal anaphylotoxin physiology
def: "OBSOLETE. functional anomaly of any of the small fragments of complement proteins released by cleavage during complement activation, they are chemotactic and vasoactive" [ISBN:0-8153-1691-7]
is_obsolete: true

[Term]
id: MP:0002507
name: obsolete abnormal C4a physiology
def: "OBSOLETE. functional anomaly of complement fragment C4a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction" [ISBN:0-397-51047-0, MGI:cwg]
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002508
name: obsolete abnormal complement 5a physiology
def: "OBSOLETE. functional anomaly of this product of complement activation that is a potent chemotactic factor for neutrophils, monocytes, and basophils and enhances smooth muscle contraction and vascular permeability" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal C5a physiology" EXACT []
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002509
name: obsolete abnormal C3a physiology
def: "OBSOLETE. functional anomaly of complement fragment C3a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction" [ISBN:0-397-51047-0, MGI:cwg]
is_obsolete: true
consider: MP:0010215

[Term]
id: MP:0002510
name: obsolete abnormal leukotriene physiology
def: "OBSOLETE. functional anomaly of any of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0]
is_obsolete: true
consider: MP:0009813

[Term]
id: MP:0002511
name: obsolete abnormal leukotriene C4 physiology
def: "OBSOLETE. any functional anomaly of the conjugation product of leukotriene a4 and glutathione; it is the major arachidonic acid metabolite in macrophages and mast cells as well as in antigen-sensitized lung tissue, and it normally stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle" [http://cancerweb.ncl.ac.uk]
synonym: "abnormal LTC4 physiology" EXACT []
is_obsolete: true
consider: MP:0009813

[Term]
id: MP:0002512
name: obsolete abnormal leukotriene D4 physiology
def: "OBSOLETE. any functional anomaly of a leukotriene c4 derivative generated after partial hydrolysis of the gamma-glutamyl portion of the peptide chain; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability" [http://cancerweb.ncl.ac.uk]
synonym: "abnormal LTD4 physiology" EXACT []
is_obsolete: true
consider: MP:0009813

[Term]
id: MP:0002513
name: obsolete abnormal leukotriene E4 physiology
def: "OBSOLETE. any functional anomaly of a leukotriene d4 derivative generated by a peptidase reaction that removes the glycine residue; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability" [http://cancerweb.ncl.ac.uk]
synonym: "abnormal LTE4 physiology" EXACT []
is_obsolete: true
consider: MP:0009813

[Term]
id: MP:0002514
name: obsolete abnormal prostaglandin physiology
def: "OBSOLETE. functional anomaly of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8]
is_obsolete: true
consider: MP:0009811

[Term]
id: MP:0002515
name: obsolete PGD2
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "prostaglandin D2" EXACT []
is_obsolete: true
consider: MP:0009811

[Term]
id: MP:0002516
name: obsolete abnormal PGE2 physiology
def: "OBSOLETE. functional anomaly of this member of the prostaglandin family, which normally has vasodilatory effects, increasing vascular permeability" [ISBN:0-397-51047-0]
synonym: "abnormal prostaglandin E2 physiology" EXACT []
is_obsolete: true
consider: MP:0009811

[Term]
id: MP:0002517
name: obsolete abnormal PGI2 physiology
def: "OBSOLETE. functional anomaly of this member of the prostaglandin family that normally has vasodilatory effects, increasing vascular permeability" [ISBN:0-397-51047-0]
synonym: "abnormal prostacyclin physiology" EXACT []
synonym: "abnormal prostaglandin I2 physiology" EXACT []
is_obsolete: true
consider: MP:0009811

[Term]
id: MP:0002518
name: obsolete abnormal PGF2alpha physiology
def: "OBSOLETE. functional anomaly of this prostaglandin that normally has vasocontractile, oxytocic, luteolytic, and abortifacient activities" [MGI:cwg]
synonym: "abnormal prostaglandin F2alpha physiology" EXACT []
is_obsolete: true
consider: MP:0009811

[Term]
id: MP:0002519
name: obsolete abnormal thromboxane physiology
def: "OBSOLETE. functional anomaly of any of the members of a family of mediators with vasoactive effects" [MGI:cwg]
synonym: "abnormal TxB2 physiology" EXACT []
is_obsolete: true
consider: MP:0009818

[Term]
id: MP:0002520
name: obsolete abnormal TxA2 physiology
def: "OBSOLETE. functional anomaly of this potent vasoconstrictor that also mediates platelet aggregation" [ISBN:0-397-51047-0]
synonym: "abnormal thromboxane A2 physiology" EXACT []
is_obsolete: true
consider: MP:0009818

[Term]
id: MP:0002521
name: obsolete abnormal platelet activating factor physiology
def: "OBSOLETE. functional anomaly of this mediator generated by nearly all activated inflammatory cells, endothelial cells, and injured tissue cells; normally it is a potent vasodilator and enhances microvasculature permeability, in addition, it induces platelet aggregation and degranulation at sites of injury and enhances the release of serotonin" [ISBN:0-397-51047-0]
synonym: "abnormal PAF physiology" EXACT []
is_obsolete: true

[Term]
id: MP:0002522
name: obsolete abnormal chemotactic factor physiology
def: "OBSOLETE. functional anomaly of any of a class of pro-inflammatory proteins that attract and activate leukocytes" [ISBN:0-397-51047-0, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002523
name: obsolete abnormal chemotactic complement factor physiology
def: "OBSOLETE. functional anomaly of any of a subset of complement fragments that are involved in recruitment of leukocytes to the site of injury" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "chemotactic complement factors" EXACT []
is_obsolete: true

[Term]
id: MP:0002524
name: obsolete lipoxygenase products
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002525
name: obsolete abnormal leukotriene B4 physiology
def: "OBSOLETE. functional anomaly of this product of inflammatory cell activation that is a potent chemoattractant for macrophages and neutrophils" [ISBN:0-397-51047-0, MGI:cwg]
synonym: "abnormal LTB4 physiology" EXACT []
is_obsolete: true
consider: MP:0009813

[Term]
id: MP:0002526
name: obsolete abnormal chemokine physiology
def: "OBSOLETE. functional anomaly of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200, MGI:cwg]
is_obsolete: true
consider: MP:0008721
consider: MP:0008722
consider: MP:0010209

[Term]
id: MP:0002527
name: obsolete abnormal interleukin-8 physiology
def: "OBSOLETE. functional anomaly of this protein secreted by macrophages and is chemotactic for neutrophils and T cells" [ISBN:0-8153-1691-7]
synonym: "abnormal IL-8 physiology" EXACT []
is_obsolete: true

[Term]
id: MP:0002528
name: obsolete abnormal interleukin-1 physiology
def: "OBSOLETE. functional anomaly of this soluble factor produced by macrophages/monocytes that activates vascular endothelium and lymphocytes" [ISBN:0-8153-1691-7]
comment: This term is obsolete.  Instead, use the terms abnormal circulating interleukin-1 level (MP:0008589) and its children or abnormal interleukin-1 secretion (MP:0008650) and its children.
synonym: "abnormal IL-1 physiology" EXACT []
is_obsolete: true
consider: MP:0008589
consider: MP:0008650

[Term]
id: MP:0002529
name: obsolete abnormal interleukin physiology
def: "OBSOLETE. functional anomaly of any of the cytokines produced by leukocytes" [ISBN:0-8153-1691-7]
synonym: "abnormal lymphokines physiology" EXACT []
is_obsolete: true
consider: MP:0008568
consider: MP:0008588

[Term]
id: MP:0002530
name: obsolete abnormal tumor necrosis factor physiology
def: "OBSOLETE. functional anomaly of this cytokine produced by macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7]
comment: This term is obsolete. Instead, use the terms abnormal tumor necrosis factor level (MP:0008752) and its children or abnormal tumor necrosis factor secretion (MP:0008556) and its children.
synonym: "abnormal cachectin physiology" EXACT []
synonym: "abnormal TNF physiology" EXACT []
synonym: "abnormal TNFA physiology" EXACT []
synonym: "abnormal tumor necrosis factor alpha physiology" EXACT []
is_obsolete: true
consider: MP:0008556
consider: MP:0008752

[Term]
id: MP:0002531
name: abnormal type I hypersensitivity reaction
def: "anomaly in a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [ISBN:0-397-51047-0]
comment: Examples: hay fever, asthma, and anaphylaxis.
synonym: "anaphylactic shock" EXACT []
synonym: "anaphylaxis" EXACT []
synonym: "immediate type hypersensitivity" EXACT []
is_a: MP:0002148 ! abnormal hypersensitivity reaction
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0002532
name: abnormal type II hypersensitivity reaction
def: "anomaly in the response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved" [ISBN:0-397-51047-0]
comment: Examples: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigous, and pemphigoid.
synonym: "antibody-mediated cellular toxicity" EXACT []
synonym: "cytotoxic type hypersensitivity" EXACT []
is_a: MP:0002148 ! abnormal hypersensitivity reaction
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0002533
name: abnormal type III hypersensitivity reaction
def: "anomaly in the tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury" [ISBN:0-397-51047-0]
comment: Examples: Autoimmune diseases: systemic lupus erythmatosus (SLE), rheumatoid arthritis, sjogren syndrome, scleroderma and glomerulonephritis.
synonym: "immune complex mediated hypersensitivity" EXACT []
is_a: MP:0002148 ! abnormal hypersensitivity reaction
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0002534
name: abnormal type IV hypersensitivity reaction
def: "anomaly in an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [ISBN:0-397-51047-0]
comment: Examples: granulomatous diseases: tuberculosis, sarcoidosis. contact dermatitis: elicited by poison ivy, detergents, clothing, etc.
synonym: "cell-mediated hypersensitivity" EXACT []
synonym: "contact hypersensitivity" EXACT []
synonym: "delayed type hypersensitivity" EXACT []
is_a: MP:0002148 ! abnormal hypersensitivity reaction
is_a: MP:0002420 ! abnormal adaptive immunity
is_a: MP:0002421 ! abnormal cell-mediated immunity
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0002535
name: obsolete combined T cell/ B cell deficiency
def: "OBSOLETE.  Use cell-mediated immunity instead.  defective or absent host defense involving both B and T cells" [MGI:cwg]
synonym: "combined T-cell/B-cell deficiency" EXACT []
is_obsolete: true
consider: MP:0002421

[Term]
id: MP:0002536
name: obsolete severe combined immunodeficiency disease
def: "OBSOLETE. rare congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels" []
comment: This is a disease term.
synonym: "SCID" EXACT []
is_obsolete: true

[Term]
id: MP:0002538
name: obsolete Di George syndrome
def: "OBSOLETE. congenital syndrome with absence of thymus and parathyroids, causing impaired cellular immunity; immunoglobulin levels are normal" []
comment: this is a disease term, not a phenotype term
is_obsolete: true

[Term]
id: MP:0002539
name: obsolete B cell deficiency
def: "OBSOLETE. defective or absent host defense involving B cells" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "B-cell deficiency" EXACT []
synonym: "deficiency of antibody immunity" EXACT []
is_obsolete: true
consider: MP:0008071

[Term]
id: MP:0002540
name: obsolete congenital X-linked infantile hypogammaglobulinemia
def: "OBSOLETE. an immunologic deficiency state characterized by very low level of generally all classes of gamma-immunoglobulins" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0002541
name: obsolete selective IgA deficiency
def: "OBSOLETE. an immunologic deficiency state characterized by very low levels of the immunoglobulin class A" [MGI:cwg]
is_obsolete: true
consider: MP:0001807

[Term]
id: MP:0002543
name: brachyphalangia
def: "abnormally short phalanges" [ISBN:0-683-40008-8]
synonym: "short phalanges" EXACT []
is_a: MP:0004686 ! decreased length of long bones
is_a: MP:0005306 ! abnormal phalanx morphology

[Term]
id: MP:0002544
name: brachydactyly
def: "abnormally short digits" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "short digits" EXACT []
synonym: "short fingers" NARROW []
synonym: "short toes" NARROW []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0002546
name: mydriasis
alt_id: MP:0001321
alt_id: MP:0002860
def: "increased diameter of one or both central circular aperture of the iris through which light rays enter the eye" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "dilated pupil" EXACT []
synonym: "dilated pupils" EXACT []
synonym: "enlarged pupil" EXACT []
synonym: "enlarged pupils" EXACT []
synonym: "increased pupil size" EXACT []
synonym: "large pupil" EXACT []
synonym: "large pupils" EXACT []
synonym: "pupil dilation" EXACT []
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0002551
name: abnormal blood coagulation
alt_id: MP:0000210
alt_id: MP:0001582
def: "altered ability or inability of the blood to clot" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal clotting" EXACT []
synonym: "coagulopathy" RELATED []
synonym: "haematology: abnormal blood coagulation" EXACT []
synonym: "hematology: abnormal blood coagulation" EXACT []
xref: MGI:2173585
is_a: MP:0009676 ! abnormal hemostasis

[Term]
id: MP:0002552
name: obsolete abnormal response to addictive substance
def: "OBSOLETE. aberrant behavioral or physiological reaction to an addictive substance" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true
consider: MP:0009748

[Term]
id: MP:0002553
name: preference for addictive substance
def: "strong predilection for an addictive substance" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0002554
name: aversion to addictive substance
def: "purposeful avoidance of an addictive substance due to dislike" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0002555
name: addiction
def: "strong dependence on an addictive compound such as alcohol or narcotics that results in uncontrollable cravings for such compounds" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002553 ! preference for addictive substance

[Term]
id: MP:0002556
name: abnormal cocaine consumption
alt_id: MP:0002569
def: "aberrant behavioral-related or physiological-related intake of cocaine into the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "cocaine consumption" EXACT []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0002557
name: abnormal social/conspecific interaction behavior
alt_id: MP:0001351
def: "deviation of the normal behavior of animals towards each other" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal social behavior" EXACT []
synonym: "abnormal social behaviour" EXACT []
synonym: "abnormal socialization" EXACT []
synonym: "neurological/behavioral: social/conspecific interaction anomalies" EXACT []
synonym: "neurological/behavioural: social/conspecific interaction anomalies" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002558
name: obsolete abnormal circadian period
def: "any change in the cycle length expressed when exposed to constant conditions without temporal cues" [MGI:CFG]
comment: 'has part' some \n    (duration\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002559
name: obsolete abnormal circadian persistence
def: "anomaly in the ability for an animal to retain a circadian rhythm when time cues are removed" [MGI:CFG]
comment: 'has part' some \n    (persistence\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002560
name: obsolete arrhythmic circadian persistence
def: "loss of any rhythmic pattern upon removal of time cues" [MGI:CFG]
comment: 'has part' some \n    (arrhythmic\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002561
name: obsolete abnormal circadian phase
def: "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)" [MGI:CFG]
comment: 'has part' some \n    (phase\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002562
name: obsolete prolonged circadian period
def: "increase in the cycle length expressed when exposed to constant conditions without temporal cues" [MGI:CFG]
comment: 'has part' some \n    ('increased duration'\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002563
name: obsolete shortened circadian period
def: "decrease in the cycle length expressed when exposed to constant conditions without temporal cues" [MGI:CFG]
comment: 'has part' some \n    ('decreased duration'\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
is_obsolete: true

[Term]
id: MP:0002564
name: obsolete advanced circadian phase
def: "increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)" [MGI:CFG]
comment: 'has part' some \n    ('advanced phase'\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
synonym: "decreased circadian phase delay" EXACT []
is_obsolete: true

[Term]
id: MP:0002565
name: obsolete delayed circadian phase
def: "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)" [MGI:CFG]
comment: 'has part' some \n    ('delayed phase'\n     and ('inheres in' some 'circadian rhythm')\n     and ('has modifier' some abnormal))
synonym: "increased circadian phase delay" EXACT []
is_obsolete: true

[Term]
id: MP:0002566
name: abnormal sexual interaction
alt_id: MP:0001369
alt_id: MP:0001370
alt_id: MP:0001374
def: "altered initiation, failure of initiation or incomplete mating behavior" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal breeding" EXACT []
synonym: "abnormal breeding/mating" EXACT []
synonym: "abnormal mating" EXACT []
synonym: "abnormal mating behavior" RELATED []
synonym: "abnormal mating behaviour" RELATED []
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior

[Term]
id: MP:0002567
name: obsolete abnormal odor preference
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002568
name: obsolete addiction/drug abuse
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "neurological/behavioral: addiction/drug abuse" EXACT []
is_obsolete: true

[Term]
id: MP:0002570
name: alcohol aversion
def: "purposeful avoidance of alcohol due to dislike" [https://orcid.org/0000-0003-3691-0324]
synonym: "ethanol aversion" EXACT []
is_a: MP:0001423 ! abnormal liquid preference
is_a: MP:0001425 ! abnormal alcohol consumption
is_a: MP:0002554 ! aversion to addictive substance

[Term]
id: MP:0002571
name: senility
def: "a degenerative state of brain function manifesting in an impairment of memory, judgment, attention span, problem solving skills, the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function, and a global loss of cognitive abilities" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0002572
name: abnormal emotion/affect behavior
def: "altered response in tests for emotional related behaviors" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal emotion/affect behaviour" EXACT []
synonym: "neurological/behavioral: emotion/affect abnormalities" EXACT []
synonym: "neurological/behavioural: emotion/affect abnormalities" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002573
name: behavioral despair
def: "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [PMID:11875023]
synonym: "behavioural despair" EXACT []
is_a: MP:0014414 ! increased depression-related behavior

[Term]
id: MP:0002574
name: increased vertical activity
def: "greater than average time spent jumping or rearing" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased rearing" EXACT []
synonym: "increased reconnoitering behavior" EXACT []
synonym: "increased reconnoitering behaviour" EXACT []
is_a: MP:0001399 ! hyperactivity
is_a: MP:0020167 ! abnormal vertical activity

[Term]
id: MP:0002575
name: increased circulating ketone body level
def: "greater than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [ISBN:0-683-40008-8]
comment: Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in equilibrium with acetoacetate.
synonym: "elevated circulating ketone body level" EXACT []
synonym: "elevated plasma ketone body level" NARROW []
synonym: "elevated serum ketone body level" NARROW []
synonym: "hyperketonaemia" EXACT []
synonym: "hyperketonemia" EXACT []
is_a: MP:0003457 ! abnormal circulating ketone body level
is_a: MP:0030970 ! ketosis

[Term]
id: MP:0002576
name: abnormal enamel morphology
def: "any structural anomaly of the hard outer coating of the exposed portion of the tooth" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "enamel dysplasia" NARROW []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology

[Term]
id: MP:0002577
name: reduced enamel thickness
def: "thin hard coating of the exposed portion of the tooth" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002576 ! abnormal enamel morphology

[Term]
id: MP:0002578
name: impaired ability to fire action potentials
def: "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [https://orcid.org/0000-0003-3691-0324, J:51377]
is_a: MP:0005402 ! abnormal action potential

[Term]
id: MP:0002579
name: disorganized secondary lens fibers
def: "deformation or misalignment of the elongated cells that form the crystalline lens" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "disorganised secondary lens fibres" EXACT []
is_a: MP:0002840 ! abnormal lens fiber morphology

[Term]
id: MP:0002580
name: duodenal lesions
def: "focal pathological changes characterized by alteration in the size, shape and organization of the cellular components of the duodenum epithelium tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003271 ! abnormal duodenum morphology

[Term]
id: MP:0002581
name: abnormal ileum morphology
def: "any structural anomaly of the portion of the small intestine that extends from the jejunum to the colon" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "ileum dysplasia" NARROW []
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0002582
name: disorganized extraembryonic tissue
def: "a lack of the regular arrangement of the membranes involved with the embryo's protection and nutrition" [https://orcid.org/0000-0003-3691-0324, J:40596]
synonym: "disorganised extraembryonic tissue" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0002583
name: absent extraembryonic ectoderm
def: "absence of the endoderm layer of the extraembryonic tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of extraembryonic ectoderm" EXACT []
is_a: MP:0010736 ! abnormal extraembryonic ectoderm morphology

[Term]
id: MP:0002584
name: small ectoplacental cone
def: "reduced size of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta" [MGI:cwg]
synonym: "small epamniotic cone" EXACT []
is_a: MP:0005032 ! abnormal ectoplacental cone morphology

[Term]
id: MP:0002585
name: obsolete abnormal response/metabolism to xenobiotics
def: "OBSOLETE. altered ability or inability to metabolize or respond to foreign substances" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
comment: This term has been rendered obsolete. Please use instead the terms abnormal pharmacogenetics of xenobiotics (MP:0008875) or abnormal response to xenobiotics (MP:0008872).
synonym: "abnormal metabolism of xenobiotics" EXACT []
is_obsolete: true
consider: MP:0008872
consider: MP:0008875

[Term]
id: MP:0002586
name: abnormal platelet volume
def: "anomaly in the content of platelet cells over normal" [MGI:cml]
is_a: MP:0004720 ! abnormal platelet morphology

[Term]
id: MP:0002587
name: obsolete heart/cardiovascular system: characteristics
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002588
name: obsolete blood cell characteristics
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002589
name: obsolete mean corpuscular volume traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002590
name: increased mean corpuscular volume
def: "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [ISBN:0-683-40008-8, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "high MCV" EXACT []
synonym: "high mean corpuscular volume" EXACT []
synonym: "increased MCV" EXACT []
is_a: MP:0000226 ! abnormal mean corpuscular volume

[Term]
id: MP:0002591
name: decreased mean corpuscular volume
def: "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [ISBN:0-683-40008-8, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased MCV" EXACT []
synonym: "low MCV" EXACT []
synonym: "low mean corpuscular volume" EXACT []
synonym: "reduced mean corpuscular volume" EXACT []
is_a: MP:0000226 ! abnormal mean corpuscular volume

[Term]
id: MP:0002592
name: obsolete mean erythrocyte count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
synonym: "mean red blood cell traits" EXACT []
is_obsolete: true

[Term]
id: MP:0002593
name: high mean erythrocyte cell number
def: "greater than average numbers of red blood cells" [MGI:cwg]
synonym: "high mean erythrocyte count" EXACT []
synonym: "high mean RBC count" EXACT []
synonym: "high mean red blood cell count" EXACT []
is_a: MP:0003131 ! increased erythrocyte cell number

[Term]
id: MP:0002594
name: low mean erythrocyte cell number
def: "less than average numbers of red blood cells" [MGI:cwg]
synonym: "low mean erythrocyte count" EXACT []
synonym: "low mean RBC count" EXACT []
synonym: "low mean red blood cell count" EXACT []
is_a: MP:0002875 ! decreased erythrocyte cell number

[Term]
id: MP:0002596
name: abnormal hematocrit
alt_id: MP:0000206
alt_id: MP:0001578
def: "greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MESH:E01.450.375.400]
synonym: "abnormal haematocrit" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002597
name: obsolete platelet traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002598
name: obsolete mean platelet volume traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002599
name: increased mean platelet volume
def: "increased average content of platelet cells over normal" [MGI:cml]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "high mean platelet volume" EXACT []
synonym: "increased MPV" EXACT []
synonym: "increased platelet size" BROAD []
synonym: "large platelet size" BROAD []
synonym: "large platelets" BROAD [HP:0011877]
is_a: MP:0002586 ! abnormal platelet volume

[Term]
id: MP:0002600
name: obsolete mean leukocyte count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002601
name: obsolete lymphocyte count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002602
name: abnormal eosinophil cell number
def: "deviation from the normal numbers of eosinophils" [MGI:cwg]
synonym: "abnormal eosinophil count" EXACT []
synonym: "eosinophil count traits" EXACT []
is_a: MP:0005061 ! abnormal eosinophil morphology
is_a: MP:0020201 ! abnormal granulocyte number

[Term]
id: MP:0002603
name: obsolete basophil count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002604
name: obsolete neutrophil count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002605
name: obsolete monocyte count traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002606
name: increased basophil cell number
def: "higher than average number of basophils as measured by the percent of the total number of leukocytes" [CL:0000767, https://orcid.org/0000-0003-3691-0324, MPD:Mouse_Phenome_Database]
synonym: "high basophil count" EXACT []
synonym: "increased basophil count" EXACT []
synonym: "increased basophil number" EXACT []
is_a: MP:0000322 ! increased granulocyte number
is_a: MP:0012442 ! abnormal basophil cell number

[Term]
id: MP:0002607
name: decreased basophil cell number
def: "lower than average number of basophils as measured by the percent of the total number of leukocytes" [CL:0000767, https://orcid.org/0000-0003-3691-0324, MPD:Mouse_Phenome_Database]
synonym: "decreased basophil count" EXACT []
synonym: "decreased basophil number" EXACT []
synonym: "low basophil count" EXACT []
synonym: "reduced basophil cell number" EXACT []
is_a: MP:0000334 ! decreased granulocyte number
is_a: MP:0012442 ! abnormal basophil cell number

[Term]
id: MP:0002608
name: increased hematocrit
alt_id: MP:0000207
alt_id: MP:0001579
def: "greater than average percentage of a volume of a blood sample occupied by red blood cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased haematocrit" EXACT []
is_a: MP:0002596 ! abnormal hematocrit

[Term]
id: MP:0002609
name: obsolete blood physiology traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002610
name: obsolete blood chemistry traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002611
name: obsolete glucose homeostasis traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002614
name: obsolete lipid homeostasis traits
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002619
name: abnormal lymphocyte morphology
alt_id: MP:0005063
def: "any structural anomaly of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "lymphocyte abnormalities" BROAD []
synonym: "lymphocyte structural abnormalities" EXACT []
is_a: MP:0008247 ! abnormal mononuclear cell morphology

[Term]
id: MP:0002620
name: abnormal monocyte morphology
def: "any structural anomaly of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, https://orcid.org/0000-0003-3691-0324]
synonym: "monocyte abnormalities" BROAD []
is_a: MP:0008248 ! abnormal mononuclear phagocyte morphology

[Term]
id: MP:0002621
name: delayed neural tube closure
def: "delay in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline" [J:79790, MGI:cml]
is_a: MP:0003720 ! abnormal neural tube closure

[Term]
id: MP:0002622
name: abnormal cochlear hair cell morphology
def: "any structural anomaly of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "abnormal auditory hair cell morphology" EXACT [CL:0000202]
synonym: "abnormal cochlear hair cells morphology" EXACT []
is_a: MP:0000042 ! abnormal organ of Corti morphology
is_a: MP:0000045 ! abnormal hair cell morphology
is_a: MP:0003308 ! abnormal cochlear sensory epithelium morphology

[Term]
id: MP:0002623
name: abnormal vestibular hair cell morphology
def: "any structural anomaly of the mechanoreceptor cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear; afferent and efferent nerve fibers of the vestibular nerve end synaptically on them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the statoconial membrane of the maculae and the cupula of the cristae" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal vestibular hair cells morphology" EXACT []
is_a: MP:0000034 ! abnormal inner ear vestibule morphology
is_a: MP:0000045 ! abnormal hair cell morphology

[Term]
id: MP:0002624
name: abnormal tricuspid valve morphology
def: "any structural anomaly of the valve that is located between the right atrium and the right ventricle of the heart, and contains three cusps, the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp), attached to the outer fibrous ring (annulus)" [ISBN:0-683-40008-8, MESH:A07.541.510.893]
subset: CvDC_Terms
synonym: "abnormal right atrioventricular valve morphology" EXACT [https://orcid.org/0000-0002-6490-7723, UBERON:0002134]
synonym: "abnormal right AV valve morphology" EXACT []
synonym: "abnormal tricuspid valvar morphology" EXACT []
synonym: "tricuspid valvar dysplasia" NARROW []
synonym: "tricuspid valve dysplasia" NARROW []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology

[Term]
id: MP:0002625
name: heart left ventricle hypertrophy
def: "enlargement of heart left ventricular wall and septum from the increase in size of its cells" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "hypertrophic left ventricle" EXACT []
synonym: "left ventricle hypertrophy" EXACT []
synonym: "left ventricular hypertrophy" EXACT []
xref: Fyler:3608
is_a: MP:0001625 ! cardiac hypertrophy
is_a: MP:0010579 ! increased heart left ventricle size
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
is_a: MP:0031533 ! abnormal heart left ventricle wall morphology

[Term]
id: MP:0002626
name: increased heart rate
def: "greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute" [https://orcid.org/0000-0002-0371-1954]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "tachycardia" EXACT []
is_a: MP:0001629 ! abnormal heart rate

[Term]
id: MP:0002627
name: increased teratoma incidence
def: "higher than normal incidence of generally benign germ cell-derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor; malignant tumors are highly metatstatic" [MPATH:322]
synonym: "teratoma" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0002628
name: hepatic steatosis
def: "an accumulation of fat deposits in the liver" [https://orcid.org/0000-0002-0371-1954]
synonym: "fatty liver" EXACT []
synonym: "hepatic lipidosis" RELATED []
synonym: "hepatosteatosis" EXACT []
synonym: "liver adiposis" EXACT []
synonym: "liver steatosis" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0002629
name: hyperactivity elicited by ethanol administration
def: "increased activity after ingestion of alcohol" [MGI:Nmice]
synonym: "hyperactivity elicited by alcohol administration" EXACT []
is_a: MP:0008911 ! induced hyperactivity
is_a: MP:0009751 ! enhanced behavioral response to alcohol

[Term]
id: MP:0002630
name: abnormal endocochlear potential
def: "any alterations in the electrical potential difference (+80 - 100 mV) between the endolymphatic and perilymphatic compartments of the cochlea; this potential is generated by the stria vascularis" [https://orcid.org/0000-0002-0371-1954, J:80917]
synonym: "abnormal endolymphatic potential" EXACT []
synonym: "abnormal EP" EXACT []
is_a: MP:0006335 ! abnormal hearing electrophysiology
is_a: MP:0006390 ! abnormal cochlear endolymph physiology

[Term]
id: MP:0002631
name: abnormal epididymis morphology
def: "any structural anomaly of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal parorchis morphology" EXACT []
synonym: "epididymis dysplasia" NARROW []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0002632
name: vestigial tail
def: "a trace or rudimentary caudal structure, often a short boneless filament; the degenerated remains of any tail structure" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0002633
name: persistent truncus arteriosus
def: "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "common arterial trunk" EXACT []
synonym: "persistent truncus arteriosis" EXACT []
synonym: "PTA" EXACT []
synonym: "single outflow tract" EXACT []
synonym: "truncus arteriosis" EXACT []
synonym: "truncus arteriosus" EXACT []
xref: Fyler:0500
xref: Fyler:500
is_a: MP:0010426 ! abnormal heart and great artery attachment
is_a: MP:0010454 ! abnormal truncus arteriosus septation
is_a: MP:0010651 ! aorticopulmonary septal defect

[Term]
id: MP:0002634
name: abnormal sensorimotor gating
def: "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [https://orcid.org/0000-0002-0371-1954, J:42758]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0002635
name: reduced sensorimotor gating
def: "attenuation of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [https://orcid.org/0000-0002-0371-1954]
synonym: "impaired sensorimotor gating" EXACT []
is_a: MP:0002634 ! abnormal sensorimotor gating

[Term]
id: MP:0002636
name: delayed vaginal opening
def: "the opening of the genital canal in a female occurs at a later than expected age" [MGI:cwg]
synonym: "delayed vaginal opening time" EXACT []
synonym: "late onset of vaginal opening" EXACT []
is_a: MP:0001938 ! delayed sexual maturation
is_a: MP:0020150 ! abnormal timing of vaginal opening

[Term]
id: MP:0002637
name: small uterus
def: "reduced size of the female muscular organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased uterine size" EXACT []
synonym: "decreased uterus size" EXACT []
synonym: "reduced uterine size" EXACT []
synonym: "reduced uterus size" EXACT []
synonym: "small metra" EXACT []
is_a: MP:0004902 ! abnormal uterus size

[Term]
id: MP:0002638
name: abnormal pupillary reflex
def: "alterations or failure of the pupil to change in diameter as a reflex response to any stimulus" [ISBN:0-683-40008-8, MGI:cml]
is_a: MP:0001961 ! abnormal reflex
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0002639
name: micrognathia
def: "abnormally reduced size of the jaws, especially of the mandible" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "brachygnathia" NARROW []
synonym: "brachygnathism" NARROW []
synonym: "decreased jaw size" EXACT []
synonym: "mandibular hypoplasia" NARROW []
synonym: "micrognathism" EXACT []
xref: Fyler:4163
is_a: MP:0000454 ! abnormal jaw morphology

[Term]
id: MP:0002640
name: reticulocytosis
def: "an increase in the number of circulating reticulocytes, which is normally less than 1 per cent of the total number of red blood cells" [ISBN:0-683-40008-8]
synonym: "elevated reticulocyte number" EXACT []
synonym: "increased immature erythrocyte number" EXACT []
synonym: "increased reticulocyte number" EXACT []
is_a: MP:0011913 ! abnormal reticulocyte cell number
is_a: MP:0013663 ! increased myeloid cell number

[Term]
id: MP:0002641
name: anisopoikilocytosis
def: "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, MGI:cwg]
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002642
name: anisocytosis
alt_id: MP:0000246
alt_id: MP:0001609
def: "considerable variation of the size of red blood cells compared to a normal range" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0010067 ! increased red blood cell distribution width

[Term]
id: MP:0002643
name: poikilocytosis
def: "blood cells of variable shape on smear" [J:7209, MGI:cwg]
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002644
name: decreased circulating triglyceride level
alt_id: MP:0005143
def: "reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "low plasma triacylglycerol level" NARROW []
synonym: "low plasma triglyceride level" NARROW []
synonym: "low serum triacylglycerol level" NARROW []
synonym: "low serum triglyceride level" NARROW []
synonym: "reduced circulating triglyceride level" EXACT []
is_a: MP:0005318 ! decreased triglyceride level
is_a: MP:0011969 ! abnormal circulating triglyceride level

[Term]
id: MP:0002645
name: abnormal intestinal cholesterol absorption
def: "any anomaly in the ability of the body to take up cholesterol into the blood by absorption from the small intestine" [GO:0030299, ISBN:0-683-40008-8]
is_a: MP:0005342 ! abnormal intestinal lipid absorption

[Term]
id: MP:0002646
name: increased intestinal cholesterol absorption
def: "augmented ability of the body to take up cholesterol into the blood by absorption from the small intestine" [GO:0030299, ISBN:0-683-40008-8]
synonym: "increased cholesterol absorption" RELATED []
is_a: MP:0002645 ! abnormal intestinal cholesterol absorption

[Term]
id: MP:0002647
name: decreased intestinal cholesterol absorption
def: "reduced ability of the body to take up cholesterol into the blood by absorption from the small intestine" [GO:0030299, ISBN:0-683-40008-8]
synonym: "decreased cholesterol absorption" RELATED []
synonym: "reduced cholesterol absorption" RELATED []
synonym: "reduced intestinal cholesterol absorption" EXACT []
is_a: MP:0002645 ! abnormal intestinal cholesterol absorption

[Term]
id: MP:0002648
name: delaminated enamel
def: "separation of the hard outer coating of the exposed portion of the tooth from the underlying hard tissue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002576 ! abnormal enamel morphology

[Term]
id: MP:0002649
name: abnormal enamel rod pattern
def: "any anomaly in the orientation of the structural unit of tooth enamel" [ISBN:0-683-40008-8]
is_a: MP:0002576 ! abnormal enamel morphology

[Term]
id: MP:0002650
name: abnormal ameloblast morphology
def: "any structural anomaly of the tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ (inner enamel epithelium) of a developing tooth, involved with the formation of enamel matrix" [https://medical-dictionary.thefreedictionary.com/ameloblast, PMID:19090561]
synonym: "abnormal ameloblast cell morphology" EXACT []
synonym: "abnormal enamel secreting cell morphology" EXACT []
is_a: MP:0030544 ! abnormal enamel development

[Term]
id: MP:0002651
name: abnormal sciatic nerve morphology
def: "any structural anomaly of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MESH:A08.800.800.720.450.760]
is_a: MP:0001077 ! abnormal spinal nerve morphology

[Term]
id: MP:0002652
name: thin myocardium
def: "reduced thickness of the cardiac muscle layer" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "thin myocardial wall" RELATED []
is_a: MP:0005329 ! abnormal myocardium layer morphology

[Term]
id: MP:0002653
name: abnormal ependyma morphology
def: "any structural anomaly of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [ISBN:0-683-40008-8, MGI:il]
synonym: "abnormal ependyma" BROAD []
synonym: "ependyma dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002654
name: spongiform encephalopathy
def: "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [https://orcid.org/0000-0003-3691-0324]
synonym: "spongiform degeneration" EXACT []
is_a: MP:0002229 ! neurodegeneration

[Term]
id: MP:0002655
name: abnormal keratinocyte morphology
def: "any structural anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [ISBN:0-683-40008-8]
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0002656
name: abnormal keratinocyte differentiation
def: "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [ISBN:0-683-40008-8]
is_a: MP:0002655 ! abnormal keratinocyte morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0002657
name: chondrodystrophy
def: "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [MGI:il]
synonym: "chondrodysplasia" RELATED []
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0002658
name: abnormal liver regeneration
def: "anomaly in the renewal, repair, and/or regrowth of liver tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hepatic regeneration" EXACT []
is_a: MP:0000609 ! abnormal liver physiology

[Term]
id: MP:0002659
name: pituitary gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pituitary, typically resulting in decreased size" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "hypoplastic pituitary" RELATED []
synonym: "pituitary hypoplasia" RELATED []
is_a: MP:0005361 ! small pituitary gland

[Term]
id: MP:0002660
name: abnormal caput epididymis morphology
def: "any structural anomaly of the head of the epididymis" [ISBN:0-683-40008-8]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0002661
name: abnormal corpus epididymis morphology
def: "any structural anomaly of the body of the epididymis" [ISBN:0-683-40008-8]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0002662
name: abnormal cauda epididymis morphology
def: "any structural anomaly of the tail of the epididymis" [ISBN:0-683-40008-8]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0002663
name: absent blastocoele
def: "developmental anomaly resulting in the absence of the cavity in the blastocyst of the developing embryo" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal cavitation" EXACT []
synonym: "absent blastocoel cavity" EXACT []
synonym: "failure to cavitate" EXACT []
synonym: "failure to form blastocele" EXACT []
synonym: "failure to form blastocyst cavity" EXACT []
is_a: MP:0004963 ! abnormal blastocoele morphology

[Term]
id: MP:0002664
name: decreased circulating adrenocorticotropin level
def: "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of ACTH" NARROW []
synonym: "decreased serum levels of adrenocorticotropic hormone" NARROW []
synonym: "decreased serum levels of adrenocorticotropin" NARROW []
synonym: "decreased serum levels of adrenotropic hormone" NARROW []
synonym: "decreased serum levels of adrenotropin" NARROW []
synonym: "reduced circulating adrenocorticotropin level" EXACT []
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005128 ! decreased adrenocorticotropin level

[Term]
id: MP:0002665
name: decreased circulating corticosterone level
def: "less than the normal blood amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of corticosterone" NARROW []
synonym: "hypocorticosteronaemia" EXACT []
synonym: "hypocorticosteronemia" EXACT []
synonym: "reduced circulating corticosterone level" EXACT []
is_a: MP:0003368 ! decreased circulating glucocorticoid level
is_a: MP:0005345 ! abnormal circulating corticosterone level

[Term]
id: MP:0002666
name: increased circulating aldosterone level
def: "increased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "alsosteronism" EXACT []
synonym: "elevated serum levels of aldosterone" NARROW []
synonym: "hyperaldosteronism" EXACT []
synonym: "increased plasma aldosterone" NARROW []
is_a: MP:0003373 ! increased circulating mineralocorticoid level
is_a: MP:0005346 ! abnormal circulating aldosterone level

[Term]
id: MP:0002667
name: decreased circulating aldosterone level
def: "decreased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "decreased serum aldosterone level" NARROW []
synonym: "decreased serum levels of aldosterone" NARROW []
synonym: "hypoaldosteronism" EXACT []
synonym: "reduced circulating aldosterone level" EXACT []
is_a: MP:0003374 ! decreased circulating mineralocorticoid level
is_a: MP:0005346 ! abnormal circulating aldosterone level

[Term]
id: MP:0002668
name: abnormal circulating potassium level
def: "anomalous concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [MGI:cwg]
synonym: "abnormal blood potassium level" EXACT []
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020887 ! abnormal potassium level

[Term]
id: MP:0002669
name: abnormal scrotum morphology
def: "any structural anomaly of the external sac of skin that encloses the testes" [ISBN:0-683-40008-8]
synonym: "abnormality of the scrotum" BROAD []
synonym: "scrotum dysplasia" NARROW []
is_a: MP:0009199 ! abnormal external male genitalia morphology

[Term]
id: MP:0002670
name: absent scrotum
def: "missing the external sac of skin that encloses the testes" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "absence of scrotum" EXACT []
is_a: MP:0002669 ! abnormal scrotum morphology

[Term]
id: MP:0002671
name: belted
def: "the appearance of a stripe of white fur around the circumference of the abdomen" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0002672
name: abnormal pharyngeal arch artery morphology
alt_id: MP:0001617
alt_id: MP:0001618
def: "any structural anomaly of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:cwg]
comment: Do not confuse embryonic aortic arches with the adult aortic arch (MP:0004113).
synonym: "abnormal aortic arches" EXACT []
synonym: "abnormal branchial arch arteries" EXACT []
synonym: "abnormal branchial arch artery morphology" EXACT []
synonym: "abnormal embryonic aortic arch arteries" RELATED []
synonym: "abnormal embryonic aortic arch artery morphology" EXACT []
synonym: "abnormal PAA" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology
is_a: MP:0003410 ! abnormal artery development

[Term]
id: MP:0002673
name: abnormal sperm number
def: "increased or decreased numbers of spermatozoa" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal sperm count" EXACT []
is_a: MP:0001929 ! abnormal gametogenesis

[Term]
id: MP:0002674
name: abnormal sperm motility
def: "anomalies in the mobility of the spermatozoa" [ISBN:0-683-40008-8]
is_a: MP:0004543 ! abnormal sperm physiology
is_a: MP:0020846 ! abnormal cell motility

[Term]
id: MP:0002675
name: asthenozoospermia
def: "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "asthenospermia" EXACT []
synonym: "impaired sperm motility" EXACT []
is_a: MP:0002674 ! abnormal sperm motility

[Term]
id: MP:0002676
name: uterus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the uterus, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic uterus" EXACT []
synonym: "metra hyperplasia" EXACT []
synonym: "metral hyperplasia" EXACT []
synonym: "uterine hyperplasia" EXACT []
is_a: MP:0004906 ! enlarged uterus

[Term]
id: MP:0002678
name: increased follicle recruitment
def: "greater frequency of the entry of arrested primordial follicles into the pool of growing follicles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001130 ! abnormal ovarian folliculogenesis

[Term]
id: MP:0002679
name: abnormal corpus luteum morphology
def: "any structural anomaly of the yellow endocrine body formed in the ovary after follicle rupture" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal corpora lutea" BROAD []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0002680
name: decreased corpora lutea number
def: "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased number of corpora lutea" EXACT []
synonym: "reduced corpora lutea number" EXACT []
is_a: MP:0002679 ! abnormal corpus luteum morphology

[Term]
id: MP:0002681
name: increased corpora lutea number
def: "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased number of corpora lutea" EXACT []
is_a: MP:0002679 ! abnormal corpus luteum morphology

[Term]
id: MP:0002682
name: decreased mature ovarian follicle number
def: "fewer than normal numbers of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased number of mature ovarian follicles" EXACT []
synonym: "reduced mature ovarian follicle number" EXACT []
synonym: "reduced number of mature ovarian follicles" EXACT []
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0009364 ! abnormal mature ovarian follicle morphology

[Term]
id: MP:0002683
name: delayed fertility
def: "ability to produce live offspring occurring at a later than expected age" [MGI:llw2]
is_a: MP:0001937 ! abnormal sexual maturation
is_a: MP:0002161 ! abnormal fertility/fecundity

[Term]
id: MP:0002685
name: abnormal spermatogonia proliferation
def: "anomaly in the proliferation of the spermatogonial stem cells either due to abnormal mitosis or apoptosis" [https://orcid.org/0000-0002-0371-1954, J:62271]
synonym: "abnormal proliferation of spermatogonia" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0001156 ! abnormal spermatogenesis

[Term]
id: MP:0002686
name: globozoospermia
def: "any structural anomaly of the acrosome resulting in a round sperm head" [https://orcid.org/0000-0002-0371-1954, J:57312]
synonym: "acrosome malformation of spermatozoa" EXACT []
synonym: "round sperm heads" EXACT []
synonym: "round-headed spermatozoa" EXACT []
is_a: MP:0031354 ! abnormal acrosome assembly

[Term]
id: MP:0002687
name: oligozoospermia
alt_id: MP:0002684
def: "reduced concentration of spermatozoa in the cauda epididymis or seminal fluid" [https://orcid.org/0000-0002-0371-1954, J:57312]
synonym: "decreased sperm count" EXACT []
synonym: "decreased sperm number" EXACT []
synonym: "hypospermia" RELATED [https://orcid.org/0000-0002-6490-7723]
synonym: "oligospermia" EXACT []
synonym: "reduced sperm count" EXACT []
synonym: "reduced sperm number" EXACT []
is_a: MP:0001124 ! abnormal gametes
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0002673 ! abnormal sperm number
is_a: MP:0004901 ! decreased male germ cell number

[Term]
id: MP:0002688
name: obsolete increased sensitivity to addictive substance
def: "OBSOLETE. decreased threshold to obtain a physiological or behavioral response to an addictive substance" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to addictive substance" EXACT []
synonym: "increased susceptibility to addictive substance" EXACT []
is_obsolete: true

[Term]
id: MP:0002689
name: abnormal molar morphology
def: "any structural anomaly of the most posterior teeth located on either side of the jaw, characterized by a large crown and broad chewing surface" [MESH:A14.549.167.860.525, MGI:il]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal molars" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology

[Term]
id: MP:0002690
name: akinesia
def: "acquired absence of voluntary movement or loss of the ability to move such as temporary or prolonged paralysis or freezing in place" [MGI:cml]
is_a: MP:0003313 ! abnormal locomotor activation

[Term]
id: MP:0002691
name: small stomach
def: "reduced size of the stomach" [MGI:dlb]
synonym: "decreased stomach size" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0002693
name: abnormal pancreas physiology
def: "any functional anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ISBN:0-683-40008-8]
synonym: "abnormal pancreas function" EXACT []
is_a: MP:0002164 ! abnormal gland physiology

[Term]
id: MP:0002694
name: abnormal pancreas secretion
def: "anomaly in the production and/or release of biologically active substances from pancreatic tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002693 ! abnormal pancreas physiology

[Term]
id: MP:0002695
name: abnormal circulating glucagon level
def: "anomaly in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes" [MESH:D06.472.699.587.469.500]
synonym: "abnormal circulating HG-factor level" EXACT []
synonym: "abnormal glucagon level" EXACT []
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0002696
name: decreased circulating glucagon level
def: "reduction in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes" [MESH:D06.472.699.587.469.500]
synonym: "decreased plasma glucagon levels" NARROW []
synonym: "reduced circulating glucagon level" EXACT []
is_a: MP:0002695 ! abnormal circulating glucagon level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0002697
name: abnormal eye size
def: "deviation from the average range of eye size for a given organism" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "eye size abnormalities" EXACT []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0002698
name: abnormal sclera morphology
def: "any structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea" [MESH:A09.371.784]
synonym: "abnormal sclerotic coat morphology" EXACT []
synonym: "abnormal sclerotica morphology" EXACT []
synonym: "abnormal tunica albuginea oculi morphology" EXACT []
synonym: "abnormal tunica sclerotica morphology" EXACT []
synonym: "sclera dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0002699
name: abnormal vitreous body morphology
def: "any structural anomaly of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MESH:A09.371.943]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal corpus vitreum" EXACT []
synonym: "abnormal hyaloid body" EXACT []
synonym: "abnormal vitreal body" EXACT []
synonym: "abnormal vitreum" EXACT []
synonym: "vitreous abnormalities" EXACT []
synonym: "vitreous body abnormalities" EXACT []
is_a: MP:0005195 ! abnormal posterior eye segment morphology

[Term]
id: MP:0002700
name: increased opacity of vitreous body
alt_id: MP:0001291
def: "the transparent gel filling the inner portion of the eyeball between the lens and retina becomes cloudy and impervious to light" [MGI:llw2]
synonym: "increased opacity of corpus vitreum" EXACT []
synonym: "increased opacity of eyeball" EXACT []
synonym: "increased opacity of hyaloid body" EXACT []
synonym: "increased opacity of vitreal body" EXACT []
synonym: "increased opacity of vitreum" EXACT []
synonym: "increased vitreous body opacity" EXACT []
is_a: MP:0002699 ! abnormal vitreous body morphology

[Term]
id: MP:0002702
name: decreased circulating free fatty acids level
def: "lower than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating free fatty acid level" EXACT []
synonym: "decreased circulating non-esterified fatty acids level" EXACT []
synonym: "decreased FFA level" EXACT []
synonym: "decreased free fatty acids level" RELATED []
synonym: "decreased NEFA level" RELATED []
synonym: "decreased UFA level" EXACT []
synonym: "decreased unesterified fatty acids level" EXACT []
synonym: "lowered serum free fatty acid levels" NARROW []
synonym: "reduced circulating free fatty acid level" EXACT []
synonym: "reduced circulating non-esterified fatty acids level" EXACT []
synonym: "reduced FFA level" EXACT []
synonym: "reduced free fatty acids level" RELATED []
synonym: "reduced NEFA level" RELATED []
synonym: "reduced UFA level" EXACT []
synonym: "reduced unesterified fatty acids level" EXACT []
is_a: MP:0001553 ! abnormal circulating free fatty acids level
is_a: MP:0005282 ! decreased fatty acids level

[Term]
id: MP:0002703
name: abnormal renal tubule morphology
def: "any structural anomaly of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal kidney tubule morphology" EXACT []
synonym: "abnormal renal tubules morphology" EXACT []
synonym: "kidney tubule dysplasia" NARROW []
synonym: "renal tubule dysplasia" NARROW []
is_a: MP:0003881 ! abnormal nephron morphology

[Term]
id: MP:0002704
name: tubular nephritis
def: "inflammation of the renal tubules" [ISBN:0-683-40008-8]
is_a: MP:0001859 ! kidney inflammation
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0002705
name: dilated renal tubule
def: "stretched or widened aperture of the luminal space of one or more of the loops of Henle, proximal convoluted tubules or distal convoluted tubules" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated renal tubules" EXACT []
synonym: "renal tubule dilation" EXACT []
synonym: "renal tubule ectasia" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0002706
name: abnormal kidney size
def: "anomalous physical bulk one or both of the organs responsible for urine secretion" [MGI:cwg]
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0002707
name: abnormal kidney weight
def: "anomaly in the average weight of the organs responsible for urine secretion" [MGI:cwg]
is_a: MP:0002706 ! abnormal kidney size

[Term]
id: MP:0002708
name: nephrolithiasis
alt_id: MP:0002709
def: "calculi (stones) occurring in the kidney" [MESH:C12.777.419.600]
synonym: "kidney calculi" EXACT []
synonym: "kidney calculus" EXACT []
synonym: "kidney stone" EXACT []
synonym: "kidney stones" EXACT []
synonym: "nephrolith" EXACT []
synonym: "renal calculi" RELATED []
synonym: "renal calculus" EXACT []
synonym: "renal stones" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0005360 ! urolithiasis

[Term]
id: MP:0002710
name: increased glucagon secretion
def: "greater than normal production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [MESH:D06.472.699.587.469.500]
synonym: "elevated glucagon secretion" EXACT []
is_a: MP:0003565 ! abnormal glucagon secretion

[Term]
id: MP:0002711
name: decreased glucagon secretion
def: "reduction in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [MESH:D06.472.699.587.469.500]
synonym: "reduced glucagon secretion" EXACT []
is_a: MP:0003565 ! abnormal glucagon secretion

[Term]
id: MP:0002712
name: increased circulating glucagon level
def: "increase in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes" [MESH:D06.472.699.587.469.500]
synonym: "increased plasma glucagon level" NARROW []
is_a: MP:0002695 ! abnormal circulating glucagon level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0002713
name: abnormal glycogen catabolism
def: "inability to breakdown glycogen; or reduced or increased rate of glycogen breakdown" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glucogenesis" EXACT []
synonym: "abnormal glycogenolysis" EXACT []
is_a: MP:0005438 ! abnormal glycogen homeostasis

[Term]
id: MP:0002714
name: increased glycogen catabolism rate
def: "increased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body" [MGI:cwg]
synonym: "elevated glycogen catabolism rate" RELATED []
synonym: "increased glucogenesis rate" RELATED []
synonym: "increased glycogenolysis" EXACT []
is_a: MP:0002713 ! abnormal glycogen catabolism

[Term]
id: MP:0002715
name: decreased glycogen catabolism rate
def: "decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body" [MGI:cwg]
synonym: "decreased glucogenesis rate" RELATED []
synonym: "decreased glycogenolysis" EXACT []
synonym: "reduced glycogen catabolism rate" RELATED []
is_a: MP:0002713 ! abnormal glycogen catabolism

[Term]
id: MP:0002716
name: small male preputial gland
def: "reduced size of the sebaceous glands of the corona and neck of the glans penis" [ISBN:0-683-40008-8, MGI:il]
synonym: "decreased male preputial gland size" EXACT []
synonym: "small male preputial glands" EXACT []
is_a: MP:0002717 ! abnormal male preputial gland morphology
is_a: MP:0012725 ! small sebaceous gland

[Term]
id: MP:0002717
name: abnormal male preputial gland morphology
def: "any structural anomaly of the paired, lobulated, modified sebaceous glands of the corona, the neck of the glans penis, and the inner surface of the prepuce with pheromonal functions in male rodents; male preputial secretions strongly attract females, may accelerate estrus, and have been implicated in intermale aggression; homologous to the clitoral glands (aka female preputial glands) in female rodents; there is no true anatomical equivalent in humans" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal morphology of Tyson's glands" EXACT []
synonym: "abnormal Tyson's gland morphology" EXACT []
is_a: MP:0009102 ! abnormal glans penis morphology
is_a: MP:0013325 ! abnormal male reproductive gland morphology
is_a: MP:0013329 ! abnormal preputial gland morphology

[Term]
id: MP:0002718
name: abnormal inner cell mass morphology
def: "any structural anomaly of the cells of the blastocyst that develop into the body of the embryo and some extraembryonic tissues" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "abnormal embryoblast" EXACT []
is_a: MP:0004957 ! abnormal blastocyst morphology

[Term]
id: MP:0002720
name: obsolete urogenital system: dysmorphology
alt_id: MP:0002719
def: "OBSOLETE. abnormal development of the urogenital system resulting in morphological abnormality" [https://orcid.org/0000-0003-3691-0324]
synonym: "genitourinary abnormalities" EXACT []
synonym: "genitourinary system: dysmorphology" EXACT []
synonym: "urogenital system abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0002721
name: obsolete abnormal urogenital system physiology
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002722
name: abnormal immune system organ morphology
alt_id: MP:0000686
def: "any structural anomaly of lymphoid organs" [MGI:cwg]
synonym: "abnormal lymph organ morphology" EXACT []
synonym: "immune system organ dysplasia" NARROW []
synonym: "immune system: organ abnormalities" EXACT []
is_a: MP:0000685 ! abnormal immune system morphology

[Term]
id: MP:0002723
name: abnormal immune serum protein physiology
def: "abnormal concentration or function of circulating immune proteins" [MGI:cwg]
synonym: "immune system: serum protein abnormalities" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0002724
name: enhanced wound healing
def: "increased ability to self-repair and close wounds" [J:42016, MGI:dlb]
synonym: "improved wound healing" EXACT []
is_a: MP:0005023 ! abnormal wound healing

[Term]
id: MP:0002725
name: abnormal vein morphology
def: "any structural anomaly of the blood vessels that carry blood towards the heart" [ISBN:0-683-40008-8]
synonym: "abnormal venous morphology" EXACT []
synonym: "venous abnormalities" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0002726
name: abnormal pulmonary vein morphology
def: "any structural anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [MGI:cwg]
subset: CvDC_Terms
synonym: "abnormal pulmonary veins" EXACT []
xref: Fyler:3000
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0002727
name: decreased circulating insulin level
def: "less than normal levels of insulin in the blood" [ISBN:0-683-40008-8, MGI:dlb]
subset: IMPC
subset: Sanger_Terms
synonym: "hypoinsulinaemia" EXACT []
synonym: "hypoinsulinemia" EXACT []
synonym: "reduced circulating insulin level" EXACT []
is_a: MP:0001560 ! abnormal circulating insulin level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0002728
name: absent tibia
def: "missing the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8, MGI:cml]
synonym: "absence of tibia" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology

[Term]
id: MP:0002729
name: abnormal inner ear canal morphology
def: "any structural anomaly of the tubular ducts of the inner ear" [ISBN:0-683-40008-8]
synonym: "abnormal canal morphology" RELATED []
synonym: "abnormal canals" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0002730
name: head shaking
def: "repetitive movement of the head in the horizontal plane" [https://orcid.org/0000-0002-0371-1954]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0000436 ! abnormal head movements
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0002731
name: megacolon
def: "extreme dilation of the colon" [ISBN:0-683-40008-8]
synonym: "giant colon" EXACT []
is_a: MP:0000495 ! abnormal colon morphology

[Term]
id: MP:0002732
name: increased trichoepithelioma incidence
def: "greater than the expected number of benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts, occurring in a specific population in a given time period" [MGI:il]
synonym: "trichoepithelioma" RELATED []
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0002733
name: abnormal thermal nociception
alt_id: MP:0001972
def: "abnormal capability to sense pain elicited by thermal stimulation" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal response to temperature" EXACT []
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0002734
name: abnormal mechanical nociception
alt_id: MP:0002737
def: "abnormal capability to sense pain elicited by mechanical stimulation" [https://orcid.org/0000-0002-0371-1954]
synonym: "mechanical nociception abnormalities" EXACT []
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0002735
name: abnormal chemical nociception
def: "abnormal capability to sense pain elicited by chemical stimulation" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0002736
name: abnormal nociception after inflammation
def: "changes in pain thresholds after inflammation" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0002738
name: hyperresponsive to tactile stimuli
def: "exaggerated reflex action normally induced by touch or pain" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypesthesia" RELATED []
synonym: "tactile hyperalgesia" EXACT []
is_a: MP:0005316 ! abnormal response to tactile stimuli
is_a: MP:0005407 ! hyperalgesia

[Term]
id: MP:0002739
name: abnormal olfactory bulb development
def: "abnormality in the progression of the formation of the olfactory bulb" [https://orcid.org/0000-0002-0371-1954, J:65380]
is_a: MP:0000819 ! abnormal olfactory bulb morphology
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0002740
name: heart hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart, typically resulting in decreased size" [https://orcid.org/0000-0002-0371-1954]
synonym: "hypoplastic heart" EXACT []
synonym: "myocardial hypoplasia" RELATED []
is_a: MP:0002188 ! small heart

[Term]
id: MP:0002741
name: small olfactory bulb
def: "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
synonym: "decreased olfactory bulb size" EXACT []
synonym: "reduced olfactory bulb size" EXACT []
is_a: MP:0000819 ! abnormal olfactory bulb morphology

[Term]
id: MP:0002742
name: enlarged submandibular lymph nodes
def: "increased size of the submandibular lymph nodes" [https://orcid.org/0000-0002-0371-1954]
synonym: "increased submandibular lymph node size" EXACT []
is_a: MP:0009627 ! abnormal submandibular lymph node morphology

[Term]
id: MP:0002743
name: glomerulonephritis
def: "inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response; often characterized by decreased production of urine, the presence of blood and protein in the urine, and/or by edema; often leads to kidney failure" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "glomerular nephritis" EXACT []
synonym: "GN" EXACT []
is_a: MP:0000523 ! cortical renal glomerulopathies
is_a: MP:0001859 ! kidney inflammation

[Term]
id: MP:0002745
name: abnormal atrioventricular valve morphology
def: "any structural anomaly of the valves that gate the flow of blood from the atria into the ventricles" [https://orcid.org/0000-0002-0371-1954]
subset: CvDC_Terms
synonym: "abnormal atrioventricular valves morphology" EXACT []
synonym: "abnormal AV valve morphology" EXACT []
synonym: "atrioventricular valve dysplasia" NARROW []
is_a: MP:0000285 ! abnormal heart valve morphology
is_a: MP:0010435 ! abnormal heart atrium and ventricle connection

[Term]
id: MP:0002746
name: abnormal semilunar valve morphology
def: "any structural anomaly of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal outflow tract valves morphology" EXACT []
synonym: "abnormal semi-lunar valve morphology" EXACT []
synonym: "abnormal semilunar valves morphology" EXACT []
synonym: "semi-lunar valve dysplasia" NARROW []
synonym: "semilunar valve dysplasia" NARROW []
is_a: MP:0000285 ! abnormal heart valve morphology

[Term]
id: MP:0002747
name: abnormal aortic valve morphology
def: "any structural anomaly of the valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle, and contains three cusps, the posterior (non-coronary), right anterior and left anterior cusps, attached to an outer fibrous ring (annulus)" [ISBN:0-683-40008-8, MESH:A07.541.510.110]
subset: CvDC_Terms
synonym: "abnormal aortic semi-lunar valve morphology" EXACT []
synonym: "abnormal aortic semilunar valve morphology" EXACT [https://radiopaedia.org/articles/aortic-valve, https://www.ncbi.nlm.nih.gov/books/NBK559384/]
synonym: "abnormal left arterial valve morphology" EXACT [http://www.vhlab.umn.edu/atlas/anatomy-tutorial/cardiac-valve-nomenclature.shtml]
synonym: "abnormal left semi-lunar valve morphology" EXACT []
synonym: "abnormal left semilunar valve morphology" EXACT [https://www.kenhub.com/en/library/anatomy/aortic-valve]
synonym: "abnormal left ventriculoarterial junction morphology" EXACT [https://www.kenhub.com/en/library/anatomy/aortic-valve]
synonym: "aortic valvar abnormality" BROAD []
synonym: "aortic valve dysplasia" NARROW []
xref: Fyler:1400
xref: Fyler:1408
is_a: MP:0002746 ! abnormal semilunar valve morphology
is_a: MP:0010429 ! abnormal heart left ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0002748
name: abnormal pulmonary valve morphology
def: "any structural anomaly of the valve between the right ventricle and the pulmonary trunk, and contains three cusps, the anterior, right posterior and left posterior cusps, attached to an outer fibrous ring (annulus)" [ISBN:0-683-40008-8, MESH:A07.541.510.738]
subset: CvDC_Terms
synonym: "abnormal pulmonic valve morphology" EXACT []
synonym: "abnormal right arterial valve morphology" EXACT [http://www.vhlab.umn.edu/atlas/anatomy-tutorial/cardiac-valve-nomenclature.shtml]
synonym: "abnormal right semi-lunar valve morphology" EXACT []
synonym: "abnormal right semilunar valve morphology" EXACT [http://www.vhlab.umn.edu/atlas/anatomy-tutorial/cardiac-valve-nomenclature.shtml]
synonym: "dysplastic pulmonary valve" NARROW []
synonym: "pulmonary valvar abnormality" BROAD []
synonym: "pulmonary valve dysplasia" NARROW []
xref: Fyler:1600
xref: Fyler:1602
is_a: MP:0002746 ! abnormal semilunar valve morphology
is_a: MP:0010428 ! abnormal heart right ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0002750
name: exophthalmos
alt_id: MP:0006196
def: "forward displacement, bulging, or protrusion of one or both eyeballs" [MGI:il]
subset: IMPC
subset: Sanger_Terms
synonym: "bulging eyes" EXACT []
synonym: "ocular proptosis" EXACT []
synonym: "proptosis" EXACT []
synonym: "protruding eyes" EXACT []
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0002751
name: abnormal autonomic nervous system morphology
def: "any structural anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "autonomic nervous system abnormalities" BROAD []
synonym: "autonomic nervous system dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002752
name: abnormal somatic nervous system morphology
def: "any structural anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs)" [https://orcid.org/0000-0003-3691-0324]
synonym: "somatic nervous system abnormalities" BROAD []
synonym: "somatic nervous system dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002753
name: dilated heart left ventricle
def: "the luminal space of the lower left chamber of the heart is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0002-0371-1954]
subset: CvDC_Terms
synonym: "cardiac left ventricle dilation" EXACT []
synonym: "dilated cardiac left ventricle" EXACT []
synonym: "heart left ventricle dilation" EXACT []
synonym: "heart left ventricular dilation" EXACT []
xref: Fyler:1817
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0008022 ! dilated heart ventricle

[Term]
id: MP:0002754
name: dilated heart right ventricle
def: "the luminal space of the lower right chamber of the heart is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0002-0371-1954]
subset: CvDC_Terms
synonym: "cardiac right ventricle dilation" EXACT []
synonym: "dilated cardiac right ventricle" EXACT []
synonym: "heart right ventricle dilation" EXACT []
synonym: "heart right ventricular dilation" EXACT []
xref: Fyler:1827
is_a: MP:0008022 ! dilated heart ventricle

[Term]
id: MP:0002756
name: obsolete decreased pyramidal neuron number
def: "OBSOLETE. fewer than average number of projection neurons in the hippocampus" [MGI:cml]
synonym: "decreased pyramidal cell number" EXACT []
synonym: "reduced number of pyramidal cells" EXACT []
synonym: "reduced pyramidal cell number" EXACT []
is_obsolete: true
consider: MP:0009971
consider: MP:0009974

[Term]
id: MP:0002757
name: decreased vertical activity
alt_id: MP:0001420
def: "lesser than average time spent jumping or rearing" [https://orcid.org/0000-0002-0371-1954]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced activity in rearing test" EXACT []
synonym: "reduced activity in vertical open field test" EXACT []
synonym: "reduced rearing" EXACT []
synonym: "reduced reconnoitering behavior" EXACT []
synonym: "reduced reconnoitering behaviour" EXACT []
synonym: "reduced vertical activity" EXACT []
is_a: MP:0020167 ! abnormal vertical activity
is_a: MP:0031392 ! hypoactivity

[Term]
id: MP:0002758
name: long tail
def: "increased length of tail relative to average of a given reference population" [https://orcid.org/0000-0002-0371-1954]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased tail length" EXACT []
is_a: MP:0011999 ! abnormal tail length

[Term]
id: MP:0002759
name: abnormal caudal vertebrae morphology
alt_id: MP:0000456
def: "any structural anomaly of the bony segments of the coccyx or tail" [https://orcid.org/0000-0002-0371-1954]
comment: There are usually 27-30 caudal vertebrae present in rodents.
synonym: "abnormal coccygeal vertebrae morphology" NARROW []
synonym: "abnormal tail vertebrae morphology" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0002760
name: obsolete ectopic pyramidal neurons
def: "OBSOLETE. abnormal position of one or more triangular shaped projection neurons in the hippocampus" [ISBN:0-683-40008-8]
synonym: "ectopic pyramidal cells" EXACT []
synonym: "heterotopic pyramidal cells" EXACT []
is_obsolete: true
consider: MP:0010011
consider: MP:0010012

[Term]
id: MP:0002761
name: abnormal hippocampal mossy fiber morphology
def: "absence or misprojection of axons of neuronal cells in the dentate gyrus" [J:4978, MESH:A08.186.211.464.405.200.500]
synonym: "abnormal hippocampal mossy fibers" EXACT []
synonym: "abnormal hippocampal mossy fibre morphology" EXACT []
synonym: "abnormal hippocampal mossy fibres" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0002762
name: ectopic cerebellar granule cells
def: "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
synonym: "ectopic granule cells" BROAD []
synonym: "ectopic granule neuron" BROAD []
synonym: "heterotopic granule cells" BROAD []
xref: CL:0001031
is_a: MP:0004098 ! abnormal cerebellar granule cell morphology
is_a: MP:0011723 ! ectopic neuron

[Term]
id: MP:0002763
name: ectopic Bergmann glia cells
def: "abnormal position of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8]
synonym: "heterotopic Bergmann glia cells" EXACT []
is_a: MP:0000952 ! abnormal CNS glial cell morphology
is_a: MP:0010387 ! abnormal Bergmann glial cell morphology

[Term]
id: MP:0002764
name: short tibia
def: "reduced length of the medial and larger bone of the lower leg" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased tibia length" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0004686 ! decreased length of long bones

[Term]
id: MP:0002765
name: short fibula
def: "reduced length of the lateral and smaller of bone of the lower leg" [https://orcid.org/0000-0002-0371-1954, J:12736]
synonym: "decreased fibula length" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology
is_a: MP:0004686 ! decreased length of long bones

[Term]
id: MP:0002766
name: situs inversus
def: "lateral transposition or mirroring of the viscera of the thorax and abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MESH:C16.131.810, PMID:16461029]
subset: CvDC_Terms
synonym: "situs inversus viscerum" EXACT []
synonym: "visceral inversion" EXACT []
xref: MPATH:720
is_a: MP:0004133 ! heterotaxia

[Term]
id: MP:0002767
name: situs ambiguus
def: "an abnormality in which the thoracic and abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [PMID:18039396]
subset: CvDC_Terms
synonym: "situs ambiguous" RELATED []
xref: MPATH:711
is_a: MP:0004133 ! heterotaxia

[Term]
id: MP:0002768
name: small adrenal glands
def: "reduced size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [ISBN:0-683-40008-8]
synonym: "decreased adrenal gland size" EXACT []
synonym: "reduced adrenal gland size" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0002769
name: abnormal vas deferens morphology
def: "any structural anomaly of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "abnormal ductus deferens morphology" EXACT []
synonym: "vas deferens dysplasia" NARROW []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0002770
name: absent bulbourethral gland
def: "absence of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of bulbourethral gland" EXACT []
synonym: "absent bulbo-urethral gland" EXACT []
synonym: "absent Cowper's gland" EXACT []
synonym: "absent Mery gland" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology

[Term]
id: MP:0002771
name: absent prostate gland anterior lobe
def: "absence of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [PMID:12645922, PMID:3308446]
synonym: "absence of coagulating gland" EXACT []
synonym: "absent AP" EXACT []
synonym: "absent coagulating gland" EXACT []
is_a: MP:0001163 ! abnormal prostate gland anterior lobe morphology

[Term]
id: MP:0002772
name: brachypodia
def: "decreased length of the autopod" [J:31930, MGI:il]
synonym: "decreased autopod length" EXACT []
synonym: "short feet" EXACT []
is_a: MP:0014291 ! decreased autopod size

[Term]
id: MP:0002773
name: decreased circulating luteinizing hormone level
def: "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [https://orcid.org/0000-0002-0371-1954, MESH:D06.472.699.322.576.463]
synonym: "decreased circulating luteinising hormone level" EXACT []
synonym: "decreased serum levels of LH" NARROW []
synonym: "decreased serum levels of luteinising hormone" NARROW []
synonym: "decreased serum levels of luteinizing hormone" NARROW []
synonym: "decreased serum levels of lutropin" NARROW []
synonym: "reduced circulating luteinising hormone level" EXACT []
synonym: "reduced circulating luteinizing hormone level" EXACT []
is_a: MP:0003363 ! decreased circulating gonadotropin level
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005132 ! decreased luteinizing hormone level

[Term]
id: MP:0002774
name: small prostate gland
def: "reduced size of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0002-0371-1954]
synonym: "decreased prostate gland size" EXACT []
is_a: MP:0004959 ! abnormal prostate gland size

[Term]
id: MP:0002776
name: increased Sertoli cell number
def: "increased number of the supporting cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [https://orcid.org/0000-0002-0371-1954, J:71710]
synonym: "increased sertoli cell number" EXACT []
synonym: "Sertoli cell hyperplasia" NARROW []
is_a: MP:0002784 ! abnormal Sertoli cell morphology

[Term]
id: MP:0002777
name: absent ovarian follicles
def: "absence of the sac-like structure in the ovary which surrounds an ovum" [ISBN:0-683-40008-8]
synonym: "absence of ovarian follicles" EXACT []
synonym: "absent growing ovarian follicles" NARROW []
is_a: MP:0008871 ! abnormal ovarian follicle number

[Term]
id: MP:0002778
name: meroanencephaly
def: "type of anencephaly in which the brain and cranium are present in rudimentary form" [ISBN:0-683-40008-8, MGI:il]
is_a: MP:0001890 ! anencephaly

[Term]
id: MP:0002779
name: abnormal sex gland secretion
def: "anomaly in the production and/or release of hormones from a cell or a gland of the reproductive system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005647 ! abnormal sex gland physiology

[Term]
id: MP:0002780
name: decreased circulating testosterone level
def: "reduction in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of testosterone" NARROW []
synonym: "reduced circulating testosterone level" EXACT []
synonym: "reduced serum levels of testosterone" NARROW []
is_a: MP:0005180 ! abnormal circulating testosterone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0002781
name: increased circulating testosterone level
def: "greater than the normal blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
synonym: "elevated serum levels of testosterone" NARROW []
synonym: "increased serum levels of testosterone" NARROW []
is_a: MP:0005180 ! abnormal circulating testosterone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0002782
name: abnormal testes secretion
def: "anomaly in the production and/or release of hormones from testicular tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal testicular secretion" EXACT []
is_a: MP:0002779 ! abnormal sex gland secretion
is_a: MP:0004884 ! abnormal testis physiology

[Term]
id: MP:0002783
name: abnormal ovary secretion
def: "anomaly in the production and/or release of hormones from ovarian tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ovarian secretion" EXACT []
is_a: MP:0002779 ! abnormal sex gland secretion
is_a: MP:0003507 ! abnormal ovary physiology

[Term]
id: MP:0002784
name: abnormal Sertoli cell morphology
def: "any structural anomaly of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal Sertoli cells" EXACT []
is_a: MP:0011750 ! abnormal seminiferous tubule epithelium morphology

[Term]
id: MP:0002785
name: absent Leydig cells
def: "lack of the interstitial cells of the seminiferous tubules that secrete testosterone" [https://orcid.org/0000-0002-0371-1954]
synonym: "absence of Leydig cells" EXACT []
is_a: MP:0005536 ! decreased Leydig cell number

[Term]
id: MP:0002786
name: abnormal Leydig cell morphology
def: "any structural anomaly of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH); Leydig cells are polyhedral in shape, display a large prominent nucleus, an eosinophilic cytoplasm and numerous lipid-filled vesicles" [http://en.wikipedia.org/wiki/Leydig_cell, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Leydig cells" BROAD []
is_a: MP:0011416 ! abnormal testis interstitial tissue morphology

[Term]
id: MP:0002787
name: pseudohermaphroditism
def: "unambiguous gonadal sex (i.e. possesses either testes or ovaries, consistent with chromosomal sex) but has ambiguous secondary sexual characteristics" [https://orcid.org/0000-0002-0371-1954, MGI:llw2]
synonym: "false hermaphroditism" EXACT []
is_a: MP:0002212 ! abnormal secondary sex determination

[Term]
id: MP:0002788
name: female pseudohermaphroditism
def: "pseudohermaphroditism in which the gonads are female (ovaries) and the karyotype is XX but the secondary sex characteristics are male-like or ambiguous" [https://orcid.org/0000-0002-0371-1954, MGI:llw2]
is_a: MP:0002787 ! pseudohermaphroditism

[Term]
id: MP:0002789
name: male pseudohermaphroditism
def: "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [https://orcid.org/0000-0002-0371-1954, MGI:llw2]
is_a: MP:0002787 ! pseudohermaphroditism

[Term]
id: MP:0002790
name: decreased circulating follicle stimulating hormone level
def: "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of follicle stimulating hormone" NARROW []
synonym: "decreased serum levels of follitropin" NARROW []
synonym: "decreased serum levels of FSH" NARROW []
synonym: "decreased serum levels of gametokinetic hormone" NARROW []
synonym: "reduced circulating follicle stimulating hormone level" EXACT []
is_a: MP:0003363 ! decreased circulating gonadotropin level
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005130 ! decreased follicle stimulating hormone level

[Term]
id: MP:0002791
name: steatorrhea
def: "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [ISBN:0-683-40008-8]
synonym: "fat indigestion" BROAD []
synonym: "stearrhea" EXACT []
is_a: MP:0014460 ! increased lipid level
is_a: MP:0014476 ! abnormal feces lipid level

[Term]
id: MP:0002792
name: abnormal retina vasculature morphology
alt_id: MP:0006189
def: "any anomaly of the structure or arrangement of blood vessels supplying the retina" [MGI:cml]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal retinal vasculature morphology" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
is_a: MP:0031346 ! abnormal eye vasculature morphology

[Term]
id: MP:0002794
name: lenticonus
def: "a conical bulging of the lens capsule and the underlying cortex of the eye" [ISBN:0-683-40008-8]
comment: Lenticonus refers to a conical projection of the anterior or posterior surface of the lens, whereas lentiglobus refers to a globular projection of the anterior or posterior surface of the lens.
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0002795
name: dilated cardiomyopathy
def: "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "congestive cardiomyopathy" EXACT []
xref: Fyler:1843
is_a: MP:0004937 ! dilated heart
is_a: MP:0005330 ! cardiomyopathy

[Term]
id: MP:0002796
name: impaired skin barrier function
def: "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
synonym: "increased TEWL" RELATED [https://en.wikipedia.org/wiki/Transepidermal_water_loss]
synonym: "increased trans-epidermal water loss" RELATED []
synonym: "increased transepidermal water loss" RELATED [PMID:16761956]
synonym: "increased TWL" RELATED [https://en.wikipedia.org/wiki/Transepidermal_water_loss]
is_a: MP:0001784 ! abnormal fluid regulation
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0002797
name: increased thigmotaxis
def: "greater than average preference for staying at the perimeter walls of an open area or in an enclosed versus exposed area; may be used as an indicator of increased anxiety response" [https://orcid.org/0000-0003-4606-0597, J:56814]
is_a: MP:0001363 ! increased anxiety-related response

[Term]
id: MP:0002798
name: abnormal active avoidance behavior
def: "anomaly in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [MGI:CFG]
synonym: "abnormal active avoidance behaviour" EXACT []
synonym: "active avoidance anomalies" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior

[Term]
id: MP:0002799
name: abnormal passive avoidance behavior
def: "anomaly in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [MGI:CFG]
synonym: "abnormal inhibitory avoidance behavior" EXACT []
synonym: "abnormal inhibitory avoidance behaviour" EXACT []
synonym: "abnormal passive avoidance behaviour" EXACT []
synonym: "passive avoidance anomalies" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior

[Term]
id: MP:0002800
name: abnormal short-term object recognition memory
def: "anomaly in the short-term memory for objects is established during the first few minutes after training" [MGI:CFG]
synonym: "abnormal short term object recognition memory" EXACT []
synonym: "short-term recognition memory abnormalities" EXACT []
is_a: MP:0001458 ! abnormal object recognition memory
is_a: MP:0001468 ! abnormal temporal memory

[Term]
id: MP:0002801
name: abnormal long-term object recognition memory
def: "anomaly in long-term memory for objects that is consolidated over hours and days after training" [MGI:CFG]
synonym: "abnormal long term object recognition memory" EXACT []
synonym: "long-term recognition memory abnormalities" EXACT []
is_a: MP:0001458 ! abnormal object recognition memory
is_a: MP:0001468 ! abnormal temporal memory

[Term]
id: MP:0002802
name: abnormal discrimination learning
def: "anomaly in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [MGI:CFG]
synonym: "discrimination learning abnormalities" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0002803
name: abnormal operant conditioning behavior
def: "anomaly in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [MGI:CFG]
synonym: "abnormal operant conditional behavior" RELATED []
synonym: "abnormal operant conditional behaviour" RELATED []
synonym: "abnormal operant conditioning behaviour" EXACT []
synonym: "operant conditional abnormalities" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0002804
name: abnormal motor learning
def: "anomaly in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [MGI:CFG]
synonym: "motor learning abnormalities" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0002805
name: abnormal conditioned taste aversion behavior
def: "anomaly in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness" [MGI:CFG]
synonym: "abnormal conditioned taste aversion behaviour" EXACT []
synonym: "conditioned taste aversion anomalies" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior

[Term]
id: MP:0002806
name: abnormal conditioned emotional response
def: "anomaly in an emotional response that has been acquired by conditioning" [MGI:CFG]
synonym: "conditioned emotional response anomalies" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0002807
name: abnormal eye blink conditioning behavior
def: "anomaly in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an air puff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli" [MGI:CFG]
synonym: "abnormal eye blink conditioning behaviour" EXACT []
synonym: "eye blink conditioning anomalies" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0002808
name: abnormal barbering behavior
def: "anomaly in the behavior of plucking of fur/hair or whiskers/vibrissae from other individuals of a cohort (hetero-barbering) or oneself (self-barbering); it is recognized as patches of unevenly chopped hair and the underlying skin is seldom inflamed" [ISBN:0-471-31639-3, PMID:16236465]
comment: This is a rodent specific behavior. Whisker trimming and barbering are either normal or abnormal depending on the mouse strain. Barbering is particularly common in C57BL/6 and A2G but nearly unseen in other strains. This term should always be used in relation to the control and strain should be specified.
synonym: "abnormal barbering behaviour" EXACT []
synonym: "Dalila effect" RELATED []
synonym: "hair biting" EXACT []
synonym: "hair pulling" EXACT []
is_a: MP:0001440 ! abnormal grooming behavior

[Term]
id: MP:0002809
name: increased spinal cord size
def: "larger appearance of the spinal cord" [J:83935]
synonym: "enlarged spinal cord size" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0002810
name: microcytic anemia
def: "a reduction in the mean total mass of erythrocytes in which the remaining circulating erythrocyte corpuscular volume is smaller than normal; most commonly due to iron deficiency but also sickle cell disease and other conditions that result in hemoglobin synthesis failure or insufficiency" [ISBN:0-683-40008-8]
synonym: "microcytic anaemia" EXACT []
is_a: MP:0001577 ! anemia

[Term]
id: MP:0002811
name: macrocytic anemia
def: "deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal; most commonly due to megaloblastic anemia, or a deficiency of either vitamin B12 or folic acid" [ISBN:0-683-40008-8]
synonym: "macrocytic anaemia" EXACT []
is_a: MP:0001577 ! anemia

[Term]
id: MP:0002812
name: spherocytosis
def: "the presence of sphere-shaped erythrocytes in the circulating blood" [ISBN:0-683-40008-8]
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002813
name: microcytosis
def: "the presence of unusually small erythrocytes in the circulating blood" [ISBN:0-683-40008-8]
synonym: "microcythemia" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002814
name: hyperchromasia
def: "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [ISBN:0-683-40008-8]
synonym: "hyperchromatism" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0002816
name: colitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [ISBN:0-683-40008-8]
is_a: MP:0003304 ! large intestinal inflammation

[Term]
id: MP:0002817
name: abnormal tooth mineralization
def: "abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum" [MESH:G07.700.320.186.710]
synonym: "abnormal tooth calcification" NARROW []
synonym: "tooth mineralization defects" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0003930 ! abnormal tooth hard tissue morphology

[Term]
id: MP:0002818
name: abnormal dentin morphology
def: "any structural anomaly in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MESH:A14.549.167.900.280]
synonym: "abnormal dentin" BROAD []
synonym: "dentin abnormalities" BROAD []
synonym: "dentine abnormalities" BROAD []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology

[Term]
id: MP:0002819
name: abnormal dental pulp cavity morphology
def: "any structural anomaly of the central space (cavity) of a tooth that is bounded by dentin and contains the dental pulp; the portion of the cavity within the crown of the tooth is the pulp chamber; the portion within the root is the pulp canal or root canal" [https://www.ncbi.nlm.nih.gov/mesh/68003786, ISBN:0-683-40008-8]
synonym: "abnormal tooth pulp cavity morphology" EXACT []
synonym: "dental pulp cavity abnormalities" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology

[Term]
id: MP:0002820
name: abnormal premaxilla morphology
def: "any structural anomaly of the anterior and inner portion of the maxilla" [ISBN:0-683-40008-8]
synonym: "abnormal incisive bone morphology" EXACT []
synonym: "abnormal incisor bone morphology" EXACT []
synonym: "abnormal intermaxillary bone morphology" EXACT []
synonym: "abnormal premaxilla" BROAD []
synonym: "premaxilla dysplasia" BROAD []
is_a: MP:0000455 ! abnormal maxilla morphology

[Term]
id: MP:0002822
name: catalepsy
def: "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [ISBN:0-683-40008-8, MESH:C10.597.350.200]
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002823
name: abnormal rib development
def: "anomalous formation of the bones forming the bony wall of the chest" [https://orcid.org/0000-0002-0371-1954, J:84754]
is_a: MP:0000150 ! abnormal rib morphology
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0002824
name: abnormal chorioallantoic fusion
def: "anomaly in the process by which a highly vascularized extra-embryonic fetal membrane is formed by fusion of the chorion and allantois; in most mammals, the chorioallantois constitutes the fetal portion of the placenta" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
is_a: MP:0001712 ! abnormal placenta development

[Term]
id: MP:0002825
name: abnormal notochord morphology
def: "any structural anomaly of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8]
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0002826
name: tonic seizures
def: "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [MGI:hdene]
is_a: MP:0000947 ! convulsive seizures

[Term]
id: MP:0002827
name: abnormal renal corpuscle morphology
def: "any structural anomaly of the structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron" [ISBN:0-683-40008-8]
synonym: "abnormal cortical renal corpuscle morphology" EXACT []
synonym: "abnormal malphighian corpuscle morphology" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
is_a: MP:0003881 ! abnormal nephron morphology

[Term]
id: MP:0002828
name: abnormal renal glomerular capsule morphology
def: "any structural anomaly of the expanded beginning of a nephron that contains the glomerulus" [https://orcid.org/0000-0002-0371-1954]
synonym: "abnormal Bowman's capsule" EXACT []
synonym: "abnormal capsula glomeruli" EXACT []
synonym: "abnormal malphighian capsule" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology

[Term]
id: MP:0002829
name: abnormal juxtaglomerular apparatus morphology
def: "any structural anomaly of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [https://orcid.org/0000-0002-0371-1954, MESH:A05.810.453.324.359.520]
synonym: "juxtaglomerular complex morphology" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology

[Term]
id: MP:0002830
name: gallstones
def: "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [ISBN:0-683-40008-8, MESH:C06.130.409.633, MGI:il]
synonym: "biliary caliculi" EXACT []
synonym: "cholelithiasis" EXACT []
synonym: "gall stone" EXACT []
is_a: MP:0005083 ! abnormal biliary tract morphology

[Term]
id: MP:0002831
name: absent Peyer's patches
def: "lymphoid tissue missing from the mucosa of the small intestine" [MESH:A10.549.600]
synonym: "absence of Peyer's patches" EXACT []
is_a: MP:0000696 ! abnormal Peyer's patch morphology

[Term]
id: MP:0002832
name: coarse hair
def: "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002074 ! abnormal hair texture

[Term]
id: MP:0002833
name: increased heart weight
def: "greater than average weight of the heart compared to controls" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000274 ! enlarged heart
is_a: MP:0004857 ! abnormal heart weight

[Term]
id: MP:0002834
name: decreased heart weight
def: "less than average weight of the heart compared to controls" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced heart weight" EXACT []
is_a: MP:0002188 ! small heart
is_a: MP:0004857 ! abnormal heart weight

[Term]
id: MP:0002835
name: abnormal cranial suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the bones of the head" [https://orcid.org/0000-0002-0371-1954, MESH:A02.835.232.781.200]
synonym: "abnormal cranial sutures" EXACT []
is_a: MP:0000438 ! abnormal cranium morphology
is_a: MP:0030229 ! abnormal craniofacial suture morphology

[Term]
id: MP:0002836
name: abnormal chorion morphology
def: "any structural anomaly of the outermost extraembryonic membrane" [MESH:A10.615.284.473]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0002837
name: dystrophic cardiac calcinosis
def: "a condition characterized by the localized deposition of calcium salts in the heart; often occurring in association with inflammation or atherosclerotic lesions and other pathological states" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "calcified heart" EXACT []
synonym: "dystrophic cardiac cutis" EXACT []
synonym: "heart calcification" EXACT []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0002838
name: decreased susceptibility to dystrophic cardiac calcinosis
def: "less likely to be stricken by dystrophic cardiac calcinosis" [MGI:il]
synonym: "increased resistance to dystrophic cardiac calcinosis" EXACT []
is_a: MP:0002837 ! dystrophic cardiac calcinosis

[Term]
id: MP:0002839
name: increased susceptibility to dystrophic cardiac calcinosis
def: "more likely to be stricken by dystrophic cardiac calcinosis" [MGI:il]
synonym: "decreased resistance to dystrophic cardiac calcinosis" EXACT []
is_a: MP:0002837 ! dystrophic cardiac calcinosis

[Term]
id: MP:0002840
name: abnormal lens fiber morphology
def: "any structural anomaly of the elongated cells of the crystalline lens of the eye" [ISBN:0-683-40008-8]
synonym: "abnormal lens fibre morphology" EXACT []
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0002841
name: impaired skeletal muscle contractility
alt_id: MP:0000739
def: "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "impaired striated muscle contractility" EXACT []
is_a: MP:0000738 ! impaired muscle contractility

[Term]
id: MP:0002842
name: increased systemic arterial blood pressure
def: "increased tension of the blood within the systemic arteries" [https://orcid.org/0000-0003-3691-0324]
synonym: "high blood pressure" EXACT []
is_a: MP:0000230 ! abnormal systemic arterial blood pressure

[Term]
id: MP:0002843
name: decreased systemic arterial blood pressure
def: "decreased tension of the blood within the systemic arteries" [https://orcid.org/0000-0003-3691-0324]
synonym: "low blood pressure" EXACT []
synonym: "reduced blood pressure" EXACT []
is_a: MP:0000230 ! abnormal systemic arterial blood pressure

[Term]
id: MP:0002844
name: aortic hypertrophy
def: "increase in the bulk size of the aorta" [RGD:cur]
is_a: MP:0000272 ! abnormal aorta morphology

[Term]
id: MP:0002845
name: abnormal aortic weight
def: "anomaly in the average weight of the aorta" [RGD:cur]
synonym: "abnormal aorta weight" EXACT []
is_a: MP:0000272 ! abnormal aorta morphology

[Term]
id: MP:0002846
name: abnormal aortic mass
def: "altered physical volume or bulk of the aorta" [RGD:cur]
is_a: MP:0000272 ! abnormal aorta morphology

[Term]
id: MP:0002847
name: abnormal renal glomerular filtration rate
def: "anomaly in the rate of the process in which plasma is filtered through the glomerular membrane, which consists of capillary endothelial cells, the basement membrane, and epithelial cells; the glomerular filtrate is the same as plasma except it has no significant amount of protein" [GO:0003094]
synonym: "abnormal GFR" EXACT []
synonym: "abnormal kidney glomerular filtration rate" EXACT []
is_a: MP:0013284 ! abnormal renal glomerular filtration

[Term]
id: MP:0002848
name: obsolete increased surface glomeruli
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0002849
name: abnormal saccharin consumption
def: "anomaly in the amount of saccharin consumed in relation to other food" [RGD:cur]
is_a: MP:0005449 ! abnormal food intake

[Term]
id: MP:0002850
name: saccharin preference
def: "subjects demonstrate predilection for saccharine over other offered substance" [RGD:cur]
is_a: MP:0011976 ! sweet preference

[Term]
id: MP:0002851
name: abnormal circulating sulfate level
def: "altered concentration of sulfate in the blood" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0020891 ! abnormal sulfate level

[Term]
id: MP:0002852
name: hypersulfatemia
def: "abnormally high concentration of sulfate in the circulating blood" [J:86561]
synonym: "hypersulfataemia" EXACT []
synonym: "hypersulphataemia" EXACT []
is_a: MP:0002851 ! abnormal circulating sulfate level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0002853
name: hyposulfatemia
def: "abnormally low concentration of sulfate in the circulating blood" [J:86561]
synonym: "hyposulfataemia" EXACT []
synonym: "hyposulphataemia" EXACT []
is_a: MP:0002851 ! abnormal circulating sulfate level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0002855
name: abnormal cochlear ganglion morphology
def: "any structural anomaly of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [ISBN:0-683-40008-8]
synonym: "abnormal auditory ganglion" EXACT []
synonym: "abnormal cochlear ganglia morphology" EXACT []
synonym: "abnormal Corti ganglion" EXACT []
synonym: "abnormal spiral ganglion of vestibulocochlear (VIII) nerve" EXACT []
synonym: "cranial ganglion VIII" BROAD []
is_a: MP:0000960 ! abnormal sensory ganglion morphology
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0002856
name: abnormal vestibular ganglion morphology
def: "any structural anomaly of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [ISBN:0-683-40008-8]
synonym: "abnormal Scarpa ganglion" EXACT []
synonym: "abnormal vestibular ganglia morphology" EXACT []
synonym: "abnormal vestibular ganglion of the vestibulocochlear (VIII) nerve" EXACT []
synonym: "cranial ganglion VIII" BROAD []
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0002857
name: cochlear ganglion degeneration
def: "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [ISBN:0-683-40008-8]
synonym: "degeneration of cochlear ganglion" EXACT []
synonym: "degeneration of spiral ganglion" EXACT []
is_a: MP:0002855 ! abnormal cochlear ganglion morphology

[Term]
id: MP:0002858
name: abnormal posterior semicircular canal morphology
def: "any structural anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [ISBN:0-683-40008-8]
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0002859
name: abnormal inner ear canal fusion
def: "any structural anomaly or mistiming of the fusion of the canal primordia during development" [J:75619]
synonym: "abnormal canal fusion" RELATED []
is_a: MP:0002729 ! abnormal inner ear canal morphology

[Term]
id: MP:0002861
name: abnormal tail bud morphology
def: "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0006281 ! abnormal tail development

[Term]
id: MP:0002862
name: abnormal righting response
def: "altered ability or changed amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position" [ISBN:0-683-40008-8, MGI:hdene]
subset: Europhenome_Terms
subset: IMPC
synonym: "altered righting response" EXACT []
is_a: MP:0001516 ! abnormal motor coordination/balance
is_a: MP:0002980 ! abnormal postural reflex

[Term]
id: MP:0002863
name: improved righting response
def: "faster ability or less amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position" [ISBN:0-683-40008-8]
is_a: MP:0002862 ! abnormal righting response

[Term]
id: MP:0002864
name: abnormal ocular fundus morphology
def: "any structural anomaly of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MESH:A09.371.729.313]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal fundus oculus" EXACT []
is_a: MP:0005195 ! abnormal posterior eye segment morphology

[Term]
id: MP:0002865
name: increased growth rate
def: "reduced length of time to reach a developmental stage or stages" [J:32208, MGI:il]
is_a: MP:0001731 ! abnormal postnatal growth

[Term]
id: MP:0002866
name: abnormal glutamic acid decarboxylase level
def: "aberrant concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues" [MESH:D08.811.520.224.125.250, RGD:cur]
synonym: "abnormal GAD level" EXACT []
synonym: "abnormal glutamate decarboxylase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0002867
name: increased glutamic acid decarboxylase level
def: "greater than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide and regulates GABA levels in nervous tissues" [MESH:D08.811.520.224.125.250, RGD:cur]
synonym: "increased GAD level" EXACT []
synonym: "increased glutamate decarboxylase level" EXACT []
is_a: MP:0002866 ! abnormal glutamic acid decarboxylase level
is_a: MP:0014448 ! increased enzyme/coenzyme level

[Term]
id: MP:0002868
name: decreased glutamic acid decarboxylase level
def: "less than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues" [MESH:D08.811.520.224.125.250, RGD:cur]
synonym: "decreased GAD level" RELATED []
synonym: "decreased glutamate decarboxylase level" EXACT []
synonym: "reduced glutamate decarboxylase level" EXACT []
synonym: "reduced glutamic acid decarboxylase level" EXACT []
is_a: MP:0002866 ! abnormal glutamic acid decarboxylase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level

[Term]
id: MP:0002869
name: increased anti-insulin autoantibody level
def: "elevated level of antibodies to insulin present in the sera" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003725 ! increased autoantibody level

[Term]
id: MP:0002870
name: decreased anti-insulin autoantibody level
def: "reduced level of antibodies to insulin present in the sera" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced anti-insulin autoantibody level" EXACT []
is_a: MP:0003726 ! decreased autoantibody level

[Term]
id: MP:0002871
name: albuminuria
alt_id: MP:0005539
def: "presence of excess albumin in the urine" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased albumin excretion" EXACT []
synonym: "increased urine albumin level" EXACT []
is_a: MP:0002962 ! increased urine protein level

[Term]
id: MP:0002872
name: polycythemia
def: "an excess of circulating red blood cells" [ISBN:0-683-40008-8, MESH:C15.378.738]
synonym: "increased circulating red blood cell number" EXACT []
synonym: "polycythaemia" EXACT []
is_a: MP:0003131 ! increased erythrocyte cell number

[Term]
id: MP:0002873
name: normal phenotype
def: "no phenotypic distinctions from controls" [https://orcid.org/0000-0003-4606-0597]
comment: grouping class, not used for annotations
synonym: "fertile" RELATED []
synonym: "viable" RELATED []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0002874
name: decreased hemoglobin content
def: "decrease in the total hemoglobin content in the circulating blood" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased haemoglobin content" EXACT []
synonym: "reduced haemoglobin content" EXACT []
synonym: "reduced hemoglobin content" EXACT []
is_a: MP:0005563 ! abnormal hemoglobin content

[Term]
id: MP:0002875
name: decreased erythrocyte cell number
def: "reduced number of the cells that transport oxygen, red blood cells, per unit" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased definitive erythrocyte cell number" EXACT []
synonym: "decreased erythrocyte count" EXACT []
synonym: "decreased RBC count" EXACT []
synonym: "decreased red blood cell count" EXACT []
synonym: "erythrocytopenia" EXACT []
synonym: "erythropenia" EXACT []
synonym: "reduced definitive erythrocyte cell number" EXACT []
synonym: "reduced erythrocyte cell number" EXACT []
synonym: "reduced erythrocyte count" EXACT []
synonym: "reduced RBC count" EXACT []
synonym: "reduced red blood cell count" RELATED []
is_a: MP:0001586 ! abnormal erythrocyte cell number
is_a: MP:0013662 ! decreased myeloid cell number

[Term]
id: MP:0002876
name: abnormal thyroid gland physiology
def: "any functional anomaly of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body" [MESH:A06.407.900]
synonym: "abnormal thyroid function" EXACT []
synonym: "abnormal thyroid physiology" EXACT []
is_a: MP:0013561 ! abnormal endocrine gland physiology

[Term]
id: MP:0002877
name: abnormal melanocyte morphology
def: "any structural anomaly of the cells that produce pigment" [ISBN:0-683-40008-8]
comment: Note that significant differences exist among populations of melanocytes that populate the cutaneous tissue compared to melanocytes that populate ocular, auditory, and internal body sites. Extracutaneous melanotcytes synthesize melanosomes and melanin only during a short interval after arriving in their target tissue, and they retain their melanosomes throughout the life of the organism instead of transferring to neighboring cells like dermal melanocytes. General morphology and ultrastructure of extracutaneous melanocytes vary and also differ from cutaneous melanocytes.
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal melanocytes" EXACT []
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0002878
name: abnormal corticospinal tract morphology
def: "any structural anomaly of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
synonym: "abnormal pyramidal tract morphology" BROAD []
is_a: MP:0000778 ! abnormal nervous system tract morphology

[Term]
id: MP:0002879
name: increased cellular sensitivity to X-ray irradiation
def: "increased incidence of cell death following exposure to X-ray irradiation" [RGD:cur]
synonym: "decreased cellular resistance to X-ray irradiation" EXACT []
synonym: "increased cellular susceptibility to X-ray irradiation" EXACT []
is_a: MP:0004227 ! increased cellular sensitivity to ionizing radiation

[Term]
id: MP:0002880
name: opisthotonus
def: "a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward" [ISBN:0-683-40008-8]
comment: Stedman's Medical Dictionary states that both the -us and the -os spellings are correct and synonymous.
synonym: "opisthotonos" EXACT []
is_a: MP:0000743 ! muscle spasm
is_a: MP:0003492 ! abnormal involuntary movement

[Term]
id: MP:0002881
name: long hair
def: "increased average length of the coat hairs" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased hair length" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0002882
name: abnormal neuron morphology
def: "any structural anomaly of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
synonym: "neuron dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0002883
name: chromatolysis
def: "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [MGI:dlb]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0002884
name: abnormal pharyngeal arch morphology
def: "any structural anomaly of the transient structures of the embryo that develop into regions of the head, neck and ears" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal branchial arch morphology" EXACT []
synonym: "abnormal branchial arches" EXACT []
synonym: "abnormal pharyngeal arches" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0002885
name: abnormal AMPA-mediated synaptic currents
def: "change in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002886 ! abnormal glutamate-mediated receptor currents

[Term]
id: MP:0002886
name: abnormal glutamate-mediated receptor currents
def: "change in the measured amplitude, current density or duration of response to stimulation of glutamatergic receptors" [ISBN:0838580343]
synonym: "abnormal glutamate receptor currents" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002887
name: decreased susceptibility to pharmacologically induced seizures
def: "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a higher threshold to induce seizure activity" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased resistance to pharmacologically induced seizures" RELATED []
synonym: "resistance to pharmacologically induced seizures" EXACT []
is_a: MP:0000950 ! abnormal seizure response to pharmacological agent
is_a: MP:0012348 ! decreased susceptibility to induction of seizure by inducing agent

[Term]
id: MP:0002888
name: abnormal NMDA-mediated synaptic currents
def: "change in the measured amplitude, current density or duration of response to stimulation of NMDA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002886 ! abnormal glutamate-mediated receptor currents

[Term]
id: MP:0002891
name: increased insulin sensitivity
def: "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:cur]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0002892
name: decreased superior colliculus size
def: "decreased size of the paired superior eminence of the mesencephalic tectum" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased anterior quadrigeminal body size" EXACT []
synonym: "decreased corpora quadrigeminum posterius anterius size" EXACT []
synonym: "decreased size of superior colliculus" EXACT []
synonym: "reduced size of superior colliculus" EXACT []
synonym: "reduced superior colliculus size" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology

[Term]
id: MP:0002893
name: ketoaciduria
def: "elevated amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the urine, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [ISBN:0-683-40008-8]
synonym: "increased urine ketone body level" EXACT []
synonym: "ketonuria" EXACT []
is_a: MP:0010028 ! aciduria

[Term]
id: MP:0002894
name: abnormal otolith morphology
def: "any structural anomaly of the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane)" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "abnormal ear crystals" EXACT []
synonym: "abnormal otoconia" EXACT []
synonym: "abnormal otoconial crystal morphology" EXACT []
synonym: "abnormal otoliths" RELATED []
synonym: "abnormal statoconia" EXACT []
synonym: "abnormal statoliths" EXACT []
is_a: MP:0002895 ! abnormal otolithic membrane morphology

[Term]
id: MP:0002895
name: abnormal otolithic membrane morphology
def: "any structural anomaly of the gelatinous membrane which is supported by the stereocilia of the hair cells of the maculae of the saccule and utriculus of the inner ear; adhering to its surface are numerous calciferous crystalline particles called otoliths (statoconia)" [https://orcid.org/0000-0002-6490-7723, MESH:A09.246.631.909.625.125.680]
synonym: "abnormal membrana statoconiorum" BROAD []
synonym: "abnormal octoconial membrane morphology" EXACT []
synonym: "abnormal otolithic part of statoconial membrane morphology" EXACT []
is_a: MP:0004427 ! abnormal vestibular labyrinth morphology

[Term]
id: MP:0002896
name: abnormal bone mineralization
def: "defect in the process by which minerals are deposited into bone" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0002897
name: blotchy skin
def: "regions of spotted discoloration appearing in the dermal tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0002898
name: absent cartilage
def: "absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life" [ISBN:0-683-40008-8]
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0002899
name: fatigue
def: "easily exhausted due to mental or physical exertion" [ISBN:0-683-40008-8, MGI:hdene]
synonym: "fatigability" EXACT []
synonym: "fatigable" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0002900
name: abnormal urine phosphate level
def: "any change in the amount of phosphate in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0002901
name: increased urine phosphate level
def: "an increase in phosphate amount in the urine" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "hyperphosphaturia" EXACT []
synonym: "increased urinary phosphate level" EXACT []
is_a: MP:0002900 ! abnormal urine phosphate level

[Term]
id: MP:0002902
name: decreased urine phosphate level
def: "reduced phosphate amount in the urine" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "hypophosphaturia" EXACT []
synonym: "reduced urine phosphate level" EXACT []
is_a: MP:0002900 ! abnormal urine phosphate level

[Term]
id: MP:0002903
name: abnormal circulating parathyroid hormone level
def: "anomaly in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body" [https://orcid.org/0000-0002-0371-1954, MESH:D06.472.699.590]
synonym: "abnormal circulating level of parathyroid hormone" EXACT []
synonym: "abnormal circulating PTH level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0002904
name: increased circulating parathyroid hormone level
def: "greater blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body" [https://orcid.org/0000-0002-0371-1954, MESH:D06.472.699.590]
synonym: "increased circulating level of parathyroid hormone" EXACT []
synonym: "increased circulating PTH level" EXACT []
is_a: MP:0002903 ! abnormal circulating parathyroid hormone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0002905
name: decreased circulating parathyroid hormone level
def: "reduction in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body" [https://orcid.org/0000-0002-0371-1954, MESH:D06.472.699.590]
synonym: "decreased circulating level of parathyroid hormone" EXACT []
synonym: "decreased circulating PTH level" EXACT []
synonym: "reduced circulating parathyroid hormone level" EXACT []
is_a: MP:0002903 ! abnormal circulating parathyroid hormone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0002906
name: increased susceptibility to pharmacologically induced seizures
def: "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a lower threshold to induce seizure activity" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to pharmacologically induced seizures" EXACT []
synonym: "susceptibility to pharmacologically induced seizures" RELATED []
is_a: MP:0000950 ! abnormal seizure response to pharmacological agent
is_a: MP:0012349 ! increased susceptibility to induction of seizure by inducing agent

[Term]
id: MP:0002907
name: abnormal parturition
def: "defect in the process of labor and delivery in female animals" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal childbirth" NARROW []
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0002908
name: delayed wound healing
def: "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
is_a: MP:0005023 ! abnormal wound healing

[Term]
id: MP:0002909
name: abnormal adrenal gland physiology
def: "any functional anomaly of the suprarenal gland, including the ability to produce and secrete hormones" [MGI:hdene]
synonym: "abnormal adrenal gland function" EXACT []
synonym: "abnormal adrenal physiology" RELATED []
is_a: MP:0013561 ! abnormal endocrine gland physiology

[Term]
id: MP:0002910
name: abnormal excitatory postsynaptic currents
def: "any anomaly in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [ISBN:0838580343]
synonym: "abnormal EPSCs" EXACT []
synonym: "abnormal excitatory post-synaptic currents" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002911
name: abnormal inhibitory postsynaptic potential
def: "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [ISBN:0838580343]
synonym: "abnormal inhibitory post-synaptic potential" EXACT []
synonym: "abnormal IPSP" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002912
name: abnormal excitatory postsynaptic potential
def: "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [ISBN:0838580343]
synonym: "abnormal EPSP" EXACT []
synonym: "abnormal excitatory post-synaptic potential" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002913
name: abnormal PNS synaptic transmission
def: "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MESH:G04.335.880.850]
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0002914
name: abnormal endplate potential
def: "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [ISBN:0838580343]
synonym: "abnormal end plate potential activity" EXACT []
synonym: "abnormal EPP activity" EXACT []
is_a: MP:0002913 ! abnormal PNS synaptic transmission

[Term]
id: MP:0002915
name: abnormal synaptic depression
def: "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [ISBN:0838580343]
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002916
name: increased synaptic depression
def: "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [ISBN:0838580343]
is_a: MP:0002915 ! abnormal synaptic depression

[Term]
id: MP:0002917
name: decreased synaptic depression
def: "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [ISBN:0838580343]
synonym: "reduced synaptic depression" EXACT []
is_a: MP:0002915 ! abnormal synaptic depression

[Term]
id: MP:0002918
name: abnormal paired-pulse facilitation
def: "defects in the enhanced response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [ISBN:0838580343]
synonym: "abnormal paired pulse facilitation" EXACT []
synonym: "abnormal PPF" EXACT []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0002919
name: enhanced paired-pulse facilitation
def: "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [ISBN:0838580343]
synonym: "enhanced paired pulse facilitation" EXACT []
synonym: "enhanced PPF" EXACT []
is_a: MP:0002918 ! abnormal paired-pulse facilitation

[Term]
id: MP:0002920
name: decreased paired-pulse facilitation
def: "reduction in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [ISBN:0838580343]
synonym: "decreased paired pulse facilitation" EXACT []
synonym: "reduced paired-pulse facilitation" EXACT []
synonym: "reduced PPF" EXACT []
is_a: MP:0002918 ! abnormal paired-pulse facilitation

[Term]
id: MP:0002921
name: abnormal post-tetanic potentiation
def: "defects in the size or duration of potentials that persist after tetanic stimulation of central synapses" [ISBN:0838580343]
synonym: "abnormal post-tetanic potential" RELATED []
synonym: "abnormal PTP" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002922
name: decreased post-tetanic potentiation
def: "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [ISBN:0838580343]
synonym: "decreased post-tetanic potential" RELATED []
synonym: "decreased PTP" EXACT []
synonym: "reduced post-tetanic potential" EXACT []
is_a: MP:0002921 ! abnormal post-tetanic potentiation

[Term]
id: MP:0002923
name: increased post-tetanic potentiation
def: "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [ISBN:0838580343]
synonym: "increased post-tetanic potential" RELATED []
synonym: "increased PTP" EXACT []
is_a: MP:0002921 ! abnormal post-tetanic potentiation

[Term]
id: MP:0002924
name: delayed CNS synapse formation
def: "increase in time required to complete the process of generating connections between an axon and effector tissue or neuron" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004996 ! abnormal CNS synapse formation

[Term]
id: MP:0002925
name: abnormal cardiovascular development
def: "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:cur]
subset: IMPC_Prenatal
is_a: MP:0002127 ! abnormal cardiovascular system morphology

[Term]
id: MP:0002926
name: aganglionic megacolon
def: "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0002731 ! megacolon

[Term]
id: MP:0002927
name: toxic megacolon
def: "severe non-obstructive dilation of the colon" [ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0002731 ! megacolon

[Term]
id: MP:0002928
name: abnormal bile duct morphology
def: "any structural anomaly of the channels that secrete bile from the liver to the gall bladder and intestines" [MESH:A03.159.183, RGD:cur]
synonym: "abnormal bile duct" BROAD []
synonym: "bile duct dysplasia" NARROW []
is_a: MP:0002163 ! abnormal gland morphology
is_a: MP:0005083 ! abnormal biliary tract morphology

[Term]
id: MP:0002929
name: abnormal bile duct development
def: "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MESH:A03.159.183, RGD:cur]
is_a: MP:0002928 ! abnormal bile duct morphology
is_a: MP:0003943 ! abnormal hepatobiliary system development

[Term]
id: MP:0002930
name: obsolete hair cell degeneration
def: "OBSOLETE. a retrogressive impairment of function, destruction or apoptosis of the sensory epithelial cells of the inner ear" [ISBN:0-683-40008-8, RGD:cur]
is_obsolete: true
consider: MP:0004324
consider: MP:0004362

[Term]
id: MP:0002931
name: glutaricadicuria
def: "an accumulation of an intermediate of tryptophan catabolism in the urine" [ISBN:0-683-40008-8, RGD:cur]
synonym: "glutaric aciduria" EXACT []
is_a: MP:0030613 ! dicarboxylic aciduria

[Term]
id: MP:0002932
name: abnormal joint morphology
def: "any structural anomaly of the moveable articulation point of two or more bones" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "joint dysplasia" NARROW []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0002933
name: joint inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:cur]
synonym: "synovitis" NARROW [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/synovitis]
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0031169 ! abnormal joint physiology

[Term]
id: MP:0002934
name: acute joint inflammation
def: "early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the joints; initiated by injury, infection, or local immune response" [RGD:cur]
is_a: MP:0002498 ! abnormal acute inflammation
is_a: MP:0002933 ! joint inflammation

[Term]
id: MP:0002935
name: chronic joint inflammation
def: "persistent inflammatory response in the joints, often caused by persistent infection or during an autoimmune response" [RGD:cur]
is_a: MP:0002499 ! chronic inflammation
is_a: MP:0002933 ! joint inflammation

[Term]
id: MP:0002936
name: joint swelling
def: "enlargement of the joints, usually due to an accumulation of fluid" [RGD:cur]
is_a: MP:0001785 ! edema
is_a: MP:0002932 ! abnormal joint morphology

[Term]
id: MP:0002937
name: synovial hyperemia
def: "an increased blood flow to a synovial joint" [ISBN:0-683-40008-8, RGD:cur]
synonym: "synovial hyperaemia" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0002938
name: white spotting
def: "the appearance of patches of white fur" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0002939
name: head spot
def: "the appearance of a round area of white fur on the head" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002938 ! white spotting

[Term]
id: MP:0002940
name: variable body spotting
alt_id: MP:0000369
def: "the appearance of patches of white fur at random on the coat" [https://orcid.org/0000-0003-3691-0324]
synonym: "piebald" RELATED []
synonym: "variable white spotting" EXACT []
is_a: MP:0002938 ! white spotting

[Term]
id: MP:0002941
name: increased circulating alanine transaminase level
def: "increased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated alanine transaminase level" BROAD []
synonym: "elevated ALT level" BROAD []
synonym: "elevated circulating alanine transaminase level" EXACT []
synonym: "elevated glutamate pyruvate transaminase level" BROAD []
synonym: "elevated glutamic-pyruvic transaminase level" BROAD []
synonym: "elevated GPT level" BROAD []
synonym: "elevated SGPT level" NARROW []
synonym: "increased ALT level" BROAD []
synonym: "increased GPT level" BROAD []
synonym: "increased serum glutamate pyruvate transaminase level" NARROW []
synonym: "increased serum glutamic-pyruvic transaminase level" NARROW []
synonym: "increased SGPT level" NARROW []
is_a: MP:0001573 ! abnormal circulating alanine transaminase level
is_a: MP:0014450 ! increased circulating enzyme level

[Term]
id: MP:0002942
name: decreased circulating alanine transaminase level
def: "decreased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased ALT level" BROAD []
synonym: "decreased GPT level" BROAD []
synonym: "decreased serum glutamate pyruvate transaminase level" NARROW []
synonym: "decreased serum glutamic-pyruvic transaminase level" NARROW []
synonym: "decreased SGPT level" NARROW []
synonym: "reduced alanine transaminase level" BROAD []
synonym: "reduced ALT level" BROAD []
synonym: "reduced circulating alanine transaminase level" EXACT []
synonym: "reduced glutamate pyruvate transaminase level" BROAD []
synonym: "reduced glutamic-pyruvic transaminase level" BROAD []
synonym: "reduced GPT level" BROAD []
synonym: "reduced SGPT level" NARROW []
is_a: MP:0001573 ! abnormal circulating alanine transaminase level
is_a: MP:0014451 ! decreased circulating enzyme level

[Term]
id: MP:0002943
name: abnormal lactate dehydrogenase level
def: "abnormal level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate" [MeSH:D08.811.682.047.551.400]
synonym: "abnormal LDH level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0002944
name: increased lactate dehydrogenase level
def: "elevated level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate" [MeSH:D08.811.682.047.551.400]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated lactate dehydrogenase level" EXACT []
synonym: "elevated LDH level" EXACT []
synonym: "increased LDH level" EXACT []
is_a: MP:0002943 ! abnormal lactate dehydrogenase level
is_a: MP:0014448 ! increased enzyme/coenzyme level

[Term]
id: MP:0002945
name: abnormal inhibitory postsynaptic currents
def: "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "abnormal inhibitory post-synaptic currents" EXACT []
synonym: "abnormal IPSCs" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0002946
name: delayed axon extension
def: "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [GO:0048675, https://orcid.org/0000-0003-3691-0324]
synonym: "delayed axon outgrowth" EXACT []
is_a: MP:0003651 ! abnormal axon extension

[Term]
id: MP:0002947
name: increased hemangioma incidence
def: "greater than the expected number of benign tumors characterized by blood-filled spaces lined by benign endothelial cells, occurring in a specific population in a given time period; a cavernous hemangioma is characterized by large endothelial spaces (caverns), and a capillary hemangioma is characterized by small endothelial spaces" [HP:0001028, https://orcid.org/0000-0003-3691-0324]
synonym: "angioma" RELATED []
synonym: "haemangioma" RELATED []
synonym: "hemangioma" RELATED []
synonym: "increased angiomoma incidence" RELATED []
synonym: "increased haemangioma incidence" EXACT []
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0002948
name: abnormal neuron specification
def: "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [https://orcid.org/0000-0003-3691-0324, J:87948]
synonym: "abnormal neuronal specification" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0002949
name: obsolete abnormal neural crest cells
def: "OBSOLETE. defect in the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343]
is_obsolete: true
consider: MP:0009845

[Term]
id: MP:0002950
name: abnormal neural crest cell migration
def: "any anomaly in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [ISBN:0838580343]
synonym: "abnormal NCC migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0012745 ! abnormal neural crest cell physiology

[Term]
id: MP:0002951
name: small thyroid gland
def: "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "decreased thyroid gland size" EXACT []
synonym: "reduced thyroid gland size" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0002952
name: ventricular cardiomyopathy
def: "diseases of the ventricles of the heart" [MGI:cwg]
is_a: MP:0005330 ! cardiomyopathy

[Term]
id: MP:0002953
name: thick ventricular wall
def: "increased depth of the cardiac wall of the heart ventricles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0020135 ! abnormal heart ventricle wall thickness

[Term]
id: MP:0002954
name: obsolete abnormal aerobic energy metabolism
alt_id: MP:0005622
def: "OBSOLETE. defect in respiratory chain energy production (oxidative metabolism) process in all living cells where oxygen is consumed and carbon dioxide and water are produced" [ISBN:0-683-40008-8]
synonym: "abnormal cell respiration" EXACT []
synonym: "abnormal mitochondrial energy production" EXACT []
synonym: "abnormal respiratory chain function" EXACT []
is_obsolete: true
consider: MP:0010951
consider: MP:0010954
consider: MP:0010959

[Term]
id: MP:0002955
name: increased compensatory renal growth
def: "increased additional growth of a kidney upon removal of the other kidney through surgery or disease" [RGD:cur]
is_a: MP:0002706 ! abnormal kidney size

[Term]
id: MP:0002956
name: decreased compensatory renal growth
def: "decreased additional growth of a kidney upon removal of the other kidney through surgery or disease" [RGD:cur]
synonym: "reduced compensatory renal growth" EXACT []
is_a: MP:0002706 ! abnormal kidney size

[Term]
id: MP:0002957
name: increased intestinal adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the intestine" [https://orcid.org/0000-0002-0371-1954]
synonym: "intestinal adenocarcinoma" RELATED []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0009308 ! increased adenocarcinoma incidence
is_a: MP:0010279 ! increased gastrointestinal tumor incidence

[Term]
id: MP:0002958
name: cerebral aqueductal stenosis
def: "abnormal narrowing or constriction of the cerebral aqueduct that blocks the flow of cerebrospinal fluid (CSF) in the ventricular system" [https://en.wikipedia.org/wiki/Aqueductal_stenosis]
comment: Blockage of the cerebral aqueduct can lead to hydrocephalus, specifically as a common cause of congenital and/or obstructive hydrocephalus. {xref="https://www.chop.edu/conditions-diseases/hydrocephalus", comment="https://en.wikipedia.org/wiki/Aqueductal_stenosis"}
synonym: "aqueduct of midbrain stenosis" EXACT []
synonym: "aqueduct of Sylvius stenosis" EXACT []
synonym: "aqueductal stenosis" EXACT []
synonym: "cerebral aqueduct stenosis" EXACT []
synonym: "mesencephalic duct stenosis" EXACT []
synonym: "stenosis of midbrain cerebral aqueduct" EXACT []
is_a: MP:0000917 ! obstructive hydrocephaly
is_a: MP:0005537 ! abnormal cerebral aqueduct morphology

[Term]
id: MP:0002959
name: increased urine microalbumin level
def: "greater than the normal amount of microalbumin in the urine" [RGD:cur]
synonym: "increased microalbumin excretion" EXACT []
synonym: "microalbuminuria" EXACT []
is_a: MP:0002962 ! increased urine protein level

[Term]
id: MP:0002960
name: decreased urine microalbumin level
def: "less than the normal amount of microalbumin in the urine" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "decreased microalbumin excretion" EXACT []
synonym: "reduced microalbumin excretion" EXACT []
is_a: MP:0002963 ! decreased urine protein level

[Term]
id: MP:0002961
name: abnormal axon guidance
def: "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues" [ISBN:0838580343]
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0002962
name: increased urine protein level
alt_id: MP:0005160
def: "greater than the normal amount of proteins in the urine" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "increased protein excretion" EXACT []
synonym: "proteinuria" RELATED []
is_a: MP:0006315 ! abnormal urine protein level

[Term]
id: MP:0002963
name: decreased urine protein level
def: "less than the normal amount of proteins in the urine" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "decreased protein excretion" EXACT []
synonym: "reduced protein excretion" EXACT []
is_a: MP:0006315 ! abnormal urine protein level

[Term]
id: MP:0002964
name: aortic elastic tissue lesions
def: "focal pathological changes in the elastic lamella of the main trunk of the arterial system" [ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0009862 ! abnormal aorta elastic tissue morphology

[Term]
id: MP:0002965
name: increased circulating serum albumin level
def: "blood serum albumin concentration above the normal range" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyperalbuminaemia" EXACT []
synonym: "hyperalbuminemia" EXACT []
is_a: MP:0000199 ! abnormal circulating serum albumin level
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0002966
name: decreased circulating alkaline phosphatase level
alt_id: MP:0002967
def: "reduced concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating ALP level" EXACT []
synonym: "decreased plasma alkaline phosphatase level" NARROW []
synonym: "decreased serum alkaline phosphatase level" NARROW []
synonym: "reduced circulating alkaline phosphatase level" EXACT []
synonym: "reduced circulating ALP level" EXACT []
synonym: "reduced plasma alkaline phosphatase level" NARROW []
synonym: "reduced serum alkaline phosphatase level" NARROW []
is_a: MP:0000202 ! abnormal circulating alkaline phosphatase level
is_a: MP:0014451 ! decreased circulating enzyme level

[Term]
id: MP:0002968
name: increased circulating alkaline phosphatase level
alt_id: MP:0002775
def: "elevated concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated serum alkaline phosphatase level" NARROW []
synonym: "elevated serum AP level" NARROW []
synonym: "elevated serum level of alkaline phosphatase" NARROW []
synonym: "elevated serum level of AP" NARROW []
synonym: "increased circulating ALP level" EXACT []
synonym: "increased plasma alkaline phosphatase level" NARROW []
synonym: "increased serum alkaline phosphatase level" NARROW []
is_a: MP:0000202 ! abnormal circulating alkaline phosphatase level
is_a: MP:0014450 ! increased circulating enzyme level

[Term]
id: MP:0002969
name: impaired social transmission of food preference
def: "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [PMID:10792055]
is_a: MP:0012296 ! impaired discrimination learning

[Term]
id: MP:0002970
name: abnormal white adipose tissue morphology
def: "any structural anomaly of the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [ISBN:0-683-40008-8]
synonym: "abnormal white fat morphology" RELATED []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0002971
name: abnormal brown adipose tissue morphology
def: "any structural anomaly of the thermogenic form of adipose tissue that is composed of brown adipocytes" [MESH:A10.165.114.322]
synonym: "abnormal brown fat morphology" RELATED []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0002972
name: abnormal cardiac muscle contractility
def: "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume" [ISBN:0-683-40008-8]
synonym: "abnormal fractional shortening (FS)" NARROW []
synonym: "abnormal peak of aortic outflow velocity (PAV)" NARROW []
synonym: "abnormal velocity of circumferential fiber shortening (Vcfc)" NARROW []
synonym: "abnormal velocity of circumferential fibre shortening (Vcfc)" NARROW []
synonym: "abnormal ventricular ejection fraction volume" NARROW []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0005620 ! abnormal muscle contractility

[Term]
id: MP:0002975
name: vascular smooth muscle hypertrophy
def: "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:cur]
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology

[Term]
id: MP:0002976
name: vascular smooth muscle hypotrophy
def: "decrease in size or thickness of the smooth muscle of the vascular wall" [RGD:cur]
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology

[Term]
id: MP:0002977
name: obsolete abnormal patterning of the aortic arch
def: "OBSOLETE. abnormal development or differentiation of the convex portion of the aorta between the ascending and descending parts of the aorta" [ISBN:0-683-40008-8]
comment: Obsolete.  Use instead the terms abnormal aortic arch and aortic arch branch attachment (MP:0010464)  and its children or abnormal aortic arch development (MP:0010241).
is_obsolete: true
consider: MP:0010241
consider: MP:0010464

[Term]
id: MP:0002978
name: absent otoliths
def: "absence of the crystalline calciferous particles adhering to the otolithic membrane" [ISBN:0-683-40008-8]
synonym: "absent ear crystals" EXACT []
synonym: "absent otoconia" EXACT []
synonym: "absent otoconial crystals" EXACT []
synonym: "absent statoconia" EXACT []
synonym: "absent statoliths" EXACT []
is_a: MP:0003144 ! decreased otolith number

[Term]
id: MP:0002979
name: obsolete abnormal vestibular response
def: "OBSOLETE. abnormal response to changes in motion" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true
consider: MP:0004742

[Term]
id: MP:0002980
name: abnormal postural reflex
def: "any anomaly in the responses that control the normal position of the trunk and extremities and/or posture" [ISBN:0-683-40008-8]
synonym: "abnormal static reflexes" RELATED []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0002981
name: increased liver weight
def: "a greater than average weight of the bile-secreting exocrine gland" [MGI:il]
synonym: "increased hepatic weight" EXACT []
is_a: MP:0000599 ! enlarged liver
is_a: MP:0004847 ! abnormal liver weight

[Term]
id: MP:0002982
name: abnormal primordial germ cell migration
def: "any anomaly in the orderly movement of a primordial germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal germ cell migration" RELATED []
synonym: "abnormal PGC migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0020363 ! abnormal germ cell physiology

[Term]
id: MP:0002983
name: increased retina ganglion cell number
def: "greater number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [https://orcid.org/0000-0003-3691-0324, MGI:il]
synonym: "increased retinal ganglion cell number" EXACT []
is_a: MP:0006006 ! increased sensory neuron number
is_a: MP:0008056 ! abnormal retina ganglion cell morphology

[Term]
id: MP:0002984
name: retina hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the retina, typically resulting in decreased size" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "hypoplastic retina" EXACT []
synonym: "retinal hypoplasia" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0002985
name: abnormal urine calcium level
def: "any change in the amount of calcium in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0020879 ! abnormal calcium level

[Term]
id: MP:0002986
name: decreased urine calcium level
def: "abnormally low amounts of calcium in the urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypocalciuria" EXACT []
synonym: "reduced urinary calcium concentration" EXACT []
synonym: "reduced urinary calcium level" EXACT []
synonym: "reduced urine calcium level" EXACT []
is_a: MP:0002985 ! abnormal urine calcium level
is_a: MP:0014538 ! decreased calcium level

[Term]
id: MP:0002987
name: abnormal urine osmolality
def: "changes in the amount of ions in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal urine osmolarity" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0002988
name: decreased urine osmolality
def: "reduction in the amount of ions in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased urine osmolarity" EXACT []
synonym: "reduced urine osmolality" EXACT []
is_a: MP:0002987 ! abnormal urine osmolality

[Term]
id: MP:0002989
name: small kidney
def: "reduced physical bulk one or both of the organs responsible for urine secretion" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased kidney size" EXACT []
synonym: "reduced kidney size" EXACT []
is_a: MP:0002706 ! abnormal kidney size

[Term]
id: MP:0002990
name: short ureter
def: "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [ISBN:0-683-40008-8]
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0002991
name: abnormal sebaceous gland physiology
def: "any functional anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts" [MESH:A10.336.827]
synonym: "al sebaceous gland function" EXACT []
is_a: MP:0010680 ! abnormal skin adnexa physiology
is_a: MP:0013556 ! abnormal holocrine gland physiology

[Term]
id: MP:0002992
name: abnormal sebaceous lipid secretion
def: "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002991 ! abnormal sebaceous gland physiology

[Term]
id: MP:0002993
name: autoimmune arthritis
def: "autoimmune joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [ISBN:0-683-40008-8, MESH:C05.550.114]
is_a: MP:0002933 ! joint inflammation

[Term]
id: MP:0002995
name: primary sex reversal
def: "gonad type is not consistent with chromosomal sex" [MGI:llw2]
synonym: "sex-reversed gonad" EXACT []
is_a: MP:0002211 ! abnormal primary sex determination
is_a: MP:0005652 ! sex reversal

[Term]
id: MP:0002996
name: ovotestis
def: "state in which a single recognizable gonad contains both testicular and ovarian tissue" [MGI:llw2]
is_a: MP:0002211 ! abnormal primary sex determination
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0002997
name: enlarged seminal vesicle
def: "increased size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged seminal gland" EXACT []
synonym: "increased seminal vesicle size" EXACT []
is_a: MP:0004907 ! abnormal seminal vesicle size

[Term]
id: MP:0002998
name: abnormal bone remodeling
def: "aberrant process of the continuous turnover of bone matrix and mineral that involves a balance of resorption and reactive bone formation by osteoclasts and osteoblasts, respectively" [https://orcid.org/0000-0002-6490-7723, MESH:G04.185.753.150]
xref: GO:0046849
is_a: MP:0001533 ! abnormal skeleton physiology

[Term]
id: MP:0002999
name: abnormal bone healing
def: "defects in the restoration of integrity to bone after trauma" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001533 ! abnormal skeleton physiology
is_a: MP:0005023 ! abnormal wound healing

[Term]
id: MP:0003005
name: abnormal hippocampal fimbria morphology
def: "any structural anomaly of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8, MESH:A08.186.211.464.265]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal fimbra hippocampus morphology" EXACT []
synonym: "abnormal hippocampus fimbra morphology" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0003006
name: abnormal hippocampal fornix morphology
def: "any structural anomaly of the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body" [ISBN:0-683-40008-8, MESH:A08.186.211.464.265]
synonym: "abnormal fornix hippocampus morphology" EXACT []
synonym: "abnormal hippocampus fornix morphology" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0003007
name: ectopic thymus
def: "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0003008
name: enhanced long-term potentiation
def: "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [ISBN:0838580343]
synonym: "enhanced long term potentiation" EXACT []
synonym: "enhanced LTP" EXACT []
is_a: MP:0002207 ! abnormal long-term potentiation

[Term]
id: MP:0003009
name: abnormal cytokine secretion
def: "anomaly in the production or cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8153-1691-7]
is_a: MP:0002723 ! abnormal immune serum protein physiology

[Term]
id: MP:0003010
name: decreased mortality induced by ionizing radiation
def: "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [https://orcid.org/0000-0003-4606-0597, J:88888]
synonym: "reduced mortality induced by ionizing radiation" EXACT []
is_a: MP:0009764 ! decreased susceptibility to induced morbidity/mortality
is_a: MP:0020149 ! abnormal mortality induced by ionizing radiation

[Term]
id: MP:0003011
name: delayed dark adaptation
def: "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, MGI:hdene]
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0003012
name: obsolete no phenotypic analysis
def: "Obsolete no description of morphological, physiological or behavioral information presented" [https://orcid.org/0000-0003-3691-0324]
synonym: "no phenotype described" EXACT []
is_obsolete: true

[Term]
id: MP:0003014
name: abnormal kidney medulla morphology
def: "any structural anomaly of the inner portion of the kidney consisting of the renal pyramids" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal renal medulla" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003015
name: abnormal circulating bicarbonate level
def: "aberrant concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood" [MESH:D01.200.275.150.100, RGD:cur]
is_a: MP:0009642 ! abnormal blood homeostasis
is_a: MP:0031394 ! abnormal bicarbonate level

[Term]
id: MP:0003016
name: increased circulating bicarbonate level
def: "elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood" [MESH:D01.200.275.150.100, RGD:cur]
is_a: MP:0003015 ! abnormal circulating bicarbonate level

[Term]
id: MP:0003017
name: decreased circulating bicarbonate level
def: "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood" [MESH:D01.200.275.150.100, RGD:cur]
synonym: "reduced circulating bicarbonate level" EXACT []
is_a: MP:0003015 ! abnormal circulating bicarbonate level

[Term]
id: MP:0003018
name: abnormal circulating chloride level
def: "aberrant chloride concentration in the blood" [RGD:cur]
is_a: MP:0012007 ! abnormal chloride level

[Term]
id: MP:0003019
name: increased circulating chloride level
def: "elevated chloride concentration in the blood" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyperchloraemia" EXACT []
synonym: "hyperchloremia" EXACT []
is_a: MP:0003018 ! abnormal circulating chloride level

[Term]
id: MP:0003020
name: decreased circulating chloride level
def: "reduced chloride concentration in the blood" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypochloraemia" EXACT []
synonym: "hypochloremia" EXACT []
synonym: "reduced circulating chloride level" EXACT []
is_a: MP:0003018 ! abnormal circulating chloride level

[Term]
id: MP:0003021
name: abnormal coronary flow rate
def: "aberrant rate of blood flow in the blood vessels supplying the heart" [RGD:cur]
is_a: MP:0000233 ! abnormal blood flow velocity
is_a: MP:0006111 ! abnormal coronary circulation

[Term]
id: MP:0003022
name: increased coronary flow rate
def: "elevated rate of blood flow in the blood vessels supplying the heart" [RGD:cur]
is_a: MP:0003021 ! abnormal coronary flow rate

[Term]
id: MP:0003023
name: decreased coronary flow rate
def: "reduced rate of blood flow in the blood vessels supplying the heart" [RGD:cur]
synonym: "reduced coronary flow rate" EXACT []
is_a: MP:0003021 ! abnormal coronary flow rate

[Term]
id: MP:0003024
name: coronary artery stenosis
def: "abnormal narrowing or constriction of any of the blood vessels supplying the heart" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "coronary artery disease" EXACT []
is_a: MP:0004111 ! abnormal coronary artery morphology
is_a: MP:0006135 ! artery stenosis

[Term]
id: MP:0003025
name: increased vasoconstriction
alt_id: MP:0005588
def: "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased vascular smooth muscle contraction" EXACT []
is_a: MP:0000250 ! abnormal vasoconstriction

[Term]
id: MP:0003026
name: decreased vasoconstriction
alt_id: MP:0005589
def: "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [ISBN:0-683-40008-8, RGD:cur]
synonym: "decreased vascular smooth muscle contraction" EXACT []
synonym: "reduced vascular smooth muscle contraction" EXACT []
synonym: "reduced vasoconstriction" EXACT []
is_a: MP:0000250 ! abnormal vasoconstriction
is_a: MP:0000740 ! impaired smooth muscle contractility

[Term]
id: MP:0003027
name: abnormal blood pH regulation
def: "anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
is_a: MP:0004043 ! abnormal pH regulation
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0003028
name: alkalosis
def: "a pathological condition characterized by a decrease in the hydrogen ion concentration in tissues and in blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [https://orcid.org/0000-0003-0431-8641, ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0004043 ! abnormal pH regulation

[Term]
id: MP:0003029
name: alkalemia
def: "decreased concentration of H-ion in the blood or a rise in pH in the arterial blood" [https://orcid.org/0000-0003-0431-8641, ISBN:0-683-40008-8, RGD:cur]
synonym: "alkalaemia" EXACT []
is_a: MP:0003027 ! abnormal blood pH regulation

[Term]
id: MP:0003030
name: acidemia
def: "increased concentration of H-ion in the blood or a fall below normal in pH in the arterial blood" [https://orcid.org/0000-0003-0431-8641, ISBN:0-683-40008-8, RGD:cur]
synonym: "acidaemia" EXACT []
is_a: MP:0003027 ! abnormal blood pH regulation

[Term]
id: MP:0003031
name: acidosis
def: "a pathological state characterized by an increase in the hydrogen ion concentration in tissues and blood caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [https://orcid.org/0000-0003-0431-8641, ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0004043 ! abnormal pH regulation

[Term]
id: MP:0003032
name: hypocapnia
def: "reduced concentration of CO2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased partial CO2 pressure" EXACT []
is_a: MP:0003860 ! abnormal carbon dioxide level

[Term]
id: MP:0003033
name: abnormal pulmonary vascular resistance
def: "deviation from the normal force opposing blood flow in the lung blood vessels" [RGD:cur]
is_a: MP:0005532 ! abnormal vascular resistance

[Term]
id: MP:0003034
name: increased pulmonary vascular resistance
def: "greater than the normal force opposing blood flow in the lung blood vessels" [RGD:cur]
is_a: MP:0003033 ! abnormal pulmonary vascular resistance

[Term]
id: MP:0003035
name: decreased pulmonary vascular resistance
def: "less than the normal force opposing blood flow in the lung blood vessels" [RGD:cur]
synonym: "reduced pulmonary vascular resistance" EXACT []
is_a: MP:0003033 ! abnormal pulmonary vascular resistance

[Term]
id: MP:0003036
name: vertebral transformation
alt_id: MP:0000144
alt_id: MP:0000145
alt_id: MP:0000146
alt_id: MP:0000147
def: "homeotic transformation of a specific vertebrae to adopt the fate of another" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "transformation of C7 to T1" NARROW []
synonym: "transformation of L6 to S1" NARROW []
synonym: "transformation of T7 to T8" NARROW []
synonym: "transformation of TX to L1" NARROW []
synonym: "transitional vertebrae" EXACT []
synonym: "vertebral homeotic transformation" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0003037
name: increased myocardial infarct size
def: "increased size of necrotic area of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased myocardium infarct size" EXACT []
is_a: MP:0031217 ! increased susceptibility to myocardial ischemic injury

[Term]
id: MP:0003038
name: decreased myocardial infarct size
def: "decreased size of necrotic area of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [ISBN:0-683-40008-8, RGD:cur]
synonym: "decreased myocardium infarct size" EXACT []
synonym: "reduced myocardial infarct size" EXACT []
synonym: "reduced myocardium infarct size" EXACT []
is_a: MP:0031216 ! decreased susceptibility to myocardial ischemic injury

[Term]
id: MP:0003039
name: increased time of peak ischemic contracture
def: "increased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased time of peak ischaemic contracture" EXACT []
is_a: MP:0000343 ! abnormal response to cardiac infarction

[Term]
id: MP:0003040
name: decreased time of peak ischemic contracture
def: "decreased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction" [ISBN:0-683-40008-8, RGD:cur]
synonym: "decreased time of peak ischaemic contracture" EXACT []
synonym: "reduced time of peak ischaemic contracture" EXACT []
synonym: "reduced time of peak ischemic contracture" EXACT []
is_a: MP:0000343 ! abnormal response to cardiac infarction

[Term]
id: MP:0003041
name: increased time of onset of induced ischemic contracture
def: "increased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased time of onset of induced ischaemic contracture" EXACT []
is_a: MP:0000343 ! abnormal response to cardiac infarction

[Term]
id: MP:0003042
name: decreased time of onset of induced ischemic contracture
def: "decreased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction" [ISBN:0-683-40008-8, RGD:cur]
synonym: "decreased time of onset of induced ischaemic contracture" EXACT []
synonym: "reduced time of onset of induced ischaemic contracture" EXACT []
synonym: "reduced time of onset of induced ischemic contracture" EXACT []
is_a: MP:0000343 ! abnormal response to cardiac infarction

[Term]
id: MP:0003043
name: hypoalgesia
def: "decreased sensitivity to painful stimuli; can be due to chemical intervention, neuropathies or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, MESH:C10.597.751.791.400]
synonym: "increased pain threshold" EXACT []
is_a: MP:0001970 ! abnormal pain threshold

[Term]
id: MP:0003044
name: impaired basement membrane formation
def: "defect in the development of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [ISBN:0-683-40008-8]
synonym: "impaired basement lamina formation" EXACT []
is_a: MP:0004272 ! abnormal basement membrane morphology

[Term]
id: MP:0003045
name: obsolete fibrosis
def: "invasion of fibrous connective tissue into any organ or multiple organs, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723, MESH:C23.550.355]
comment: This term is not specific and has been removed.  Additional classes for fibrosis in anatomical locations have been added
is_obsolete: true

[Term]
id: MP:0003046
name: liver cirrhosis
def: "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "hepatic cirrhosis" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0003047
name: abnormal thoracic vertebrae morphology
def: "any structural anomaly of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [https://orcid.org/0000-0003-3691-0324, MESH:A02.835.232.834.892]
is_a: MP:0000459 ! abnormal presacral vertebrae morphology
is_a: MP:0004624 ! abnormal thoracic cage morphology

[Term]
id: MP:0003048
name: abnormal cervical vertebrae morphology
def: "any structural anomaly of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [https://orcid.org/0000-0003-3691-0324, MESH:A02.835.232.834.151]
is_a: MP:0000459 ! abnormal presacral vertebrae morphology

[Term]
id: MP:0003049
name: abnormal lumbar vertebrae morphology
def: "any structural anomaly of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [https://orcid.org/0000-0003-3691-0324, MESH:A02.835.232.834.519]
is_a: MP:0000459 ! abnormal presacral vertebrae morphology

[Term]
id: MP:0003050
name: abnormal sacral vertebrae morphology
def: "any structural anomaly of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-3691-0324]
comment: In humans, vertebrae S1-S5 are normally fused in maturity, with no intervertebral discs. In rodents, these vertebrae remain distinct in adulthood.
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0003051
name: curly tail
def: "a loop or corkscrew-like curl in the tail" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "curled tail" EXACT []
synonym: "loop tail" EXACT []
synonym: "looptail" EXACT []
synonym: "twisted tail" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0003052
name: omphalocele
def: "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion, that is caused by a severe body wall defect" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, PMID:20333300]
comment: Do not confuse with umbilical hernia - caused by a failure to retract the umbilical hernia that occurs normally during development.
subset: CvDC_Terms
synonym: "amniocele" EXACT []
synonym: "exomphalos" EXACT []
synonym: "exumbilication" EXACT []
xref: Fyler:4404
is_a: MP:0003257 ! abnormal abdominal wall morphology

[Term]
id: MP:0003053
name: delayed tooth eruption
def: "postponed onset of the growth of the teeth out of the gums" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0000119 ! abnormal tooth eruption

[Term]
id: MP:0003054
name: spina bifida
def: "common congenital midline defect of fusion of the vertebral arch" [MESH:C10.500.680.800]
subset: CvDC_Terms
synonym: "spinal dysraphism" BROAD []
xref: Fyler:4157
is_a: MP:0000929 ! open neural tube

[Term]
id: MP:0003055
name: abnormal long bone epiphyseal plate morphology
def: "any structural anomaly of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles" [MESH:A02.835.232.251.352]
synonym: "abnormal long bone epiphysial plate morphology" EXACT []
synonym: "abnormal long bone growth plate morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0003723 ! abnormal long bone morphology
is_a: MP:0006395 ! abnormal epiphyseal plate morphology

[Term]
id: MP:0003056
name: abnormal hyoid bone morphology
def: "any structural anomaly of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8, MGI:hdene]
synonym: "abnormal lingual bone" EXACT []
synonym: "abnormal tongue bone morphology" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0003057
name: abnormal epicardium morphology
def: "any structural anomaly of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal visceral serous pericardium of heart morphology" EXACT []
synonym: "abnormal visceral serous pericardium proper morphology" EXACT []
is_a: MP:0000288 ! abnormal pericardium morphology

[Term]
id: MP:0003058
name: increased insulin secretion
def: "greater production or release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [MESH:D06.472.699.587.740.625, RGD:cur]
synonym: "elevated insulin secretion" EXACT []
is_a: MP:0003564 ! abnormal insulin secretion

[Term]
id: MP:0003059
name: decreased insulin secretion
def: "reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [MESH:D06.472.699.587.740.625, RGD:cur]
synonym: "reduced insulin secretion" EXACT []
is_a: MP:0003564 ! abnormal insulin secretion

[Term]
id: MP:0003060
name: increased aerobic running capacity
def: "greater ability to run at defined speeds and/or distances compared to controls" [RGD:cur]
is_a: MP:0000348 ! abnormal aerobic fitness
is_a: MP:0012107 ! enhanced exercise endurance

[Term]
id: MP:0003061
name: decreased aerobic running capacity
def: "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:cur]
is_a: MP:0000348 ! abnormal aerobic fitness
is_a: MP:0012106 ! impaired exercise endurance

[Term]
id: MP:0003062
name: abnormal coping response
def: "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0003360 ! abnormal depression-related behavior

[Term]
id: MP:0003063
name: increased coping response
def: "enhanced ability to respond productively to a stressful situation" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0003062 ! abnormal coping response
is_a: MP:0014413 ! decreased depression-related behavior

[Term]
id: MP:0003064
name: decreased coping response
def: "reduced ability to respond productively to a stressful situation" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
synonym: "reduced coping response" EXACT []
is_a: MP:0003062 ! abnormal coping response
is_a: MP:0014414 ! increased depression-related behavior

[Term]
id: MP:0003065
name: abnormal liver copper level
def: "anomaly in the amount of copper present in the liver tissue" [RGD:cur]
synonym: "abnormal hepatic copper content" EXACT []
synonym: "abnormal liver copper concentration" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0003952 ! abnormal copper level

[Term]
id: MP:0003066
name: increased liver copper level
def: "a greater accumulation of copper in the liver tissue compared to controls" [RGD:cur]
synonym: "increased hepatic copper content" EXACT []
is_a: MP:0003065 ! abnormal liver copper level
is_a: MP:0014539 ! increased copper level

[Term]
id: MP:0003067
name: decreased liver copper level
def: "a reduced amount of copper in the liver tissue compared to controls" [RGD:cur]
synonym: "decreased hepatic copper content" EXACT []
synonym: "reduced hepatic copper content" EXACT []
synonym: "reduced liver copper level" EXACT []
is_a: MP:0003065 ! abnormal liver copper level
is_a: MP:0014540 ! decreased copper level

[Term]
id: MP:0003068
name: enlarged kidney
def: "larger than average size of the kidney" [https://orcid.org/0000-0002-0371-1954]
synonym: "increased kidney size" EXACT []
synonym: "nephromegaly" EXACT []
synonym: "renal enlargement" EXACT []
is_a: MP:0002706 ! abnormal kidney size
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0003069
name: abnormal superior semicircular canal morphology
def: "any structural anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal anterior semicircular canal" EXACT []
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0003070
name: increased vascular permeability
def: "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [ISBN:0-683-40008-8]
synonym: "vascular leakage" EXACT []
is_a: MP:0001619 ! abnormal vascular permeability

[Term]
id: MP:0003071
name: decreased vascular permeability
def: "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [ISBN:0-683-40008-8]
synonym: "reduced vascular permeability" EXACT []
is_a: MP:0001619 ! abnormal vascular permeability

[Term]
id: MP:0003072
name: abnormal metatarsal bone morphology
def: "any structural anomaly in the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8, ISBN:978-0028454405]
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0003073
name: abnormal metacarpal bone morphology
def: "any structural anomaly in the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8, ISBN:978-0028454405]
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0003074
name: absent metacarpal bones
def: "missing all of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8, ISBN:978-0028454405]
is_a: MP:0003073 ! abnormal metacarpal bone morphology

[Term]
id: MP:0003075
name: abnormal response to CNS ischemic injury
def: "altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of a tissue in the central nervous system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal response to CNS ischaemic injury" EXACT []
synonym: "altered response to CNS ischaemic injury" EXACT []
synonym: "altered response to CNS ischemic injury" EXACT []
synonym: "altered response to stroke" NARROW []
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0003076
name: increased susceptibility to ischemic brain injury
alt_id: MP:0006081
def: "more severe response, such as increased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of all or part of the brain compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to ischaemic brain injury" EXACT []
synonym: "decreased resistance to ischemic brain injury" EXACT []
synonym: "increased CNS stroke" EXACT []
synonym: "increased susceptibility to ischaemic brain injury" EXACT []
synonym: "increased susceptibility to spontaneous CNS ischaemia" RELATED []
synonym: "increased susceptibility to spontaneous CNS ischemia" RELATED []
is_a: MP:0003075 ! abnormal response to CNS ischemic injury
is_a: MP:0005165 ! increased susceptibility to injury
is_a: MP:0014523 ! increased response to brain injury

[Term]
id: MP:0003077
name: abnormal cell cycle
def: "failure to progress or abnormal progression through the stages of the cell cycle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0003078
name: aphakia
def: "absence of the crystalline lens of the eye" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "absence of lens" EXACT []
synonym: "absent lens" EXACT []
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0003079
name: decreased susceptibility to induced joint inflammation
def: "reduced or absent inflammatory response in the joints due to chemical or mechanical agents" [RGD:cur]
synonym: "increased resistance to induced joint inflammation" EXACT []
is_a: MP:0002933 ! joint inflammation

[Term]
id: MP:0003080
name: increased natural killer cell mediated cytotoxicity
def: "increased ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors" [GO:0042267, RGD:cur]
synonym: "competent NK cell cytolysis" EXACT []
synonym: "enhanced NK cell cytolysis" EXACT []
synonym: "increased killer activity" BROAD []
synonym: "increased natural killer cell mediated cell death" EXACT []
synonym: "increased natural killer cell mediated cell killing" EXACT []
synonym: "increased natural killer cell mediated cytolysis" EXACT []
synonym: "increased natural killer-cell mediated cytolysis" EXACT []
synonym: "increased NK cell mediated cell death" EXACT []
synonym: "increased NK cell mediated cell killing" EXACT []
synonym: "increased NK cell mediated cytolysis" EXACT []
synonym: "increased NK cell mediated cytotoxicity" EXACT []
is_a: MP:0011719 ! abnormal natural killer cell mediated cytotoxicity

[Term]
id: MP:0003081
name: abnormal soleus morphology
def: "any structural anomaly of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
is_a: MP:0021206 ! abnormal limb muscle morphology

[Term]
id: MP:0003082
name: abnormal gastrocnemius morphology
def: "any structural anomaly of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
is_a: MP:0021206 ! abnormal limb muscle morphology

[Term]
id: MP:0003083
name: abnormal tibialis anterior morphology
def: "any structural anomaly of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal TA morphology" EXACT []
is_a: MP:0021206 ! abnormal limb muscle morphology

[Term]
id: MP:0003084
name: abnormal skeletal muscle fiber morphology
def: "any structural anomaly of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal skeletal muscle fibre morphology" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0004087 ! abnormal muscle fiber morphology

[Term]
id: MP:0003085
name: abnormal egg cylinder morphology
def: "any structural anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0003086
name: hydromyelia
def: "increased fluid in the central canal of the spinal cord" [https://orcid.org/0000-0003-4606-0597]
synonym: "hydrorrhachis" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology
is_a: MP:0001785 ! edema

[Term]
id: MP:0003087
name: absent allantois
def: "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [ISBN:0-683-40008-8]
is_a: MP:0001726 ! abnormal allantois morphology

[Term]
id: MP:0003088
name: abnormal prepulse inhibition
def: "anomaly in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [https://orcid.org/0000-0003-4606-0597, J:91131]
synonym: "abnormal PPI" BROAD []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0003089
name: decreased skin tensile strength
def: "reduction in the normal maximum tension the skin can withstand without tearing" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "brittle skin" EXACT []
synonym: "reduced skin tensile strength" EXACT []
is_a: MP:0005275 ! abnormal skin tensile strength

[Term]
id: MP:0003090
name: abnormal muscle precursor cell migration
def: "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal muscle progenitor cell migration" RELATED []
synonym: "abnormal myogenic progenitor cell migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0012186 ! abnormal muscle precursor cell physiology

[Term]
id: MP:0003091
name: abnormal cell migration
def: "any anomaly in the movement of cells from one site to another, often occurring during developmental or chemotactic processes" [GO:0016477, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0020846 ! abnormal cell motility

[Term]
id: MP:0003092
name: decreased cornea stroma thickness
def: "reduced width of the lamellated connective tissue layer of the cornea" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased corneal stroma thickness" EXACT []
synonym: "reduced corneal stroma thickness" EXACT []
is_a: MP:0005300 ! abnormal cornea stroma morphology
is_a: MP:0005543 ! decreased cornea thickness

[Term]
id: MP:0003093
name: abnormal cornea anterior stroma morphology
def: "any structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea" [https://orcid.org/0000-0002-6490-7723, PMID:12556382]
synonym: "abnormal anterior cornea stroma morphology" EXACT []
synonym: "abnormal anterior corneal stroma morphology" EXACT []
synonym: "abnormal anterior stroma morphology" BROAD []
synonym: "abnormal corneal anterior stroma morphology" EXACT []
is_a: MP:0005300 ! abnormal cornea stroma morphology

[Term]
id: MP:0003094
name: abnormal cornea posterior stroma morphology
def: "any structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea" [https://orcid.org/0000-0002-6490-7723, PMID:12556382]
synonym: "abnormal corneal posterior stroma morphology" EXACT []
synonym: "abnormal posterior cornea stroma morphology" EXACT []
synonym: "abnormal posterior corneal stroma morphology" EXACT []
synonym: "abnormal posterior stroma morphology" BROAD []
is_a: MP:0005300 ! abnormal cornea stroma morphology

[Term]
id: MP:0003095
name: abnormal cornea stroma development
def: "anomalous differentiation of the lamellated connective tissue layer of the cornea" [https://orcid.org/0000-0002-6490-7723, PMID:12556382]
synonym: "abnormal corneal stroma development" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0005300 ! abnormal cornea stroma morphology

[Term]
id: MP:0003096
name: increased corneal light-scattering
def: "anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma" [https://orcid.org/0000-0003-3691-0324, J:81616]
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0003097
name: abnormal tendon stiffness
def: "altered ability of tendon to maintain tensile strength and load" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030802 ! abnormal tendon physiology

[Term]
id: MP:0003098
name: decreased tendon stiffness
def: "reduced ability of tendon to maintain tensile strength and load" [https://orcid.org/0000-0002-6490-7723, J:79915]
synonym: "reduced tendon stiffness" EXACT []
synonym: "tendon weakness" EXACT []
is_a: MP:0003097 ! abnormal tendon stiffness

[Term]
id: MP:0003099
name: retina detachment
def: "part or all of the retinal neural layer is separated from the outer pigmented layer of the retina; may occur with aging or as a result of trauma" [https://orcid.org/0000-0002-6490-7723, PMID:38485969]
synonym: "detached retina" EXACT []
synonym: "retinal detachment" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0003100
name: myopia
def: "optical condition in which only rays from a finite distance from the eye focus on the retina" [https://orcid.org/0000-0002-6490-7723, J:83544]
synonym: "near sight" EXACT []
synonym: "nearsightedness" EXACT []
synonym: "short sight" EXACT []
synonym: "shortsightedness" EXACT []
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0003101
name: high myopia
def: "an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation" [https://orcid.org/0000-0002-6490-7723, J:83544]
is_a: MP:0003100 ! myopia

[Term]
id: MP:0003102
name: sclera thinning
def: "reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through" [https://orcid.org/0000-0002-6490-7723]
synonym: "blue sclera" EXACT []
is_a: MP:0002698 ! abnormal sclera morphology

[Term]
id: MP:0003103
name: liver degeneration
def: "deterioration of the liver due to injury or disease, often accompanied by loss of function" [https://orcid.org/0000-0003-4606-0597, J:91653]
synonym: "hepatic degeneration" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0003104
name: acrania
def: "complete or partial absence of a skull; usually associated with anencephaly" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent skull" EXACT []
is_a: MP:0000438 ! abnormal cranium morphology

[Term]
id: MP:0003105
name: abnormal heart atrium morphology
def: "any structural anomaly of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [https://orcid.org/0000-0003-3691-0324, MESH:A07.541.358]
synonym: "abnormal heart atria morphology" EXACT []
synonym: "atrial dysplasia" NARROW []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0003106
name: abnormal fear-related response
def: "altered emotional response related to anticipation of specific pain or danger" [MGI:CFG]
synonym: "abnormal fear response" EXACT []
is_a: MP:0002065 ! abnormal fear/anxiety-related behavior

[Term]
id: MP:0003107
name: abnormal response to novelty
def: "alteration in amount of exploration/investigation of a novel object, situation or environment" [MGI:CFG]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002572 ! abnormal emotion/affect behavior

[Term]
id: MP:0003108
name: short zygomatic bone
def: "reduced length of the bone that forms the prominence of the cheek" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased zygomatic bone length" EXACT []
is_a: MP:0004468 ! small zygomatic bone
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0003109
name: short femur
def: "reduced length of the long bone of the thigh" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased femur length" EXACT []
is_a: MP:0004686 ! decreased length of long bones
is_a: MP:0030825 ! decreased femur size

[Term]
id: MP:0003110
name: absent malleus processus brevis
def: "absence of the short projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding the cartilaginous nodule" [https://orcid.org/0000-0002-6490-7723, PMID:12701100]
synonym: "absent malleal processus brevis" EXACT []
is_a: MP:0010324 ! abnormal malleus processus brevis morphology

[Term]
id: MP:0003111
name: abnormal cell nucleus morphology
def: "any structural anomaly of a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated; in most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing, but in some species, or in specialized cell types, RNA metabolism or DNA replication may be absent" [GO:0005634]
synonym: "abnormal nuclear compartment morphology" EXACT []
synonym: "abnormal nucleus morphology" BROAD []
is_a: MP:0014239 ! abnormal intracellular organelle morphology

[Term]
id: MP:0003112
name: enlarged parathyroid gland
def: "increased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ISBN:0-683-40008-8]
synonym: "increased parathyroid gland size" EXACT []
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0003113
name: small parathyroid gland
def: "decreased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ISBN:0-683-40008-8]
synonym: "decreased parathyroid gland size" EXACT []
synonym: "reduced parathyroid gland size" EXACT []
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0003114
name: pigmented parathyroid gland
def: "presence of melanocytes and/or melanin in either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0003115
name: abnormal respiratory system development
def: "aberrant differentiation of pulmonary tissues" [ISBN:0-683-40008-8]
is_a: MP:0002132 ! abnormal respiratory system morphology

[Term]
id: MP:0003116
name: rickets
def: "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal bone calcification" RELATED []
is_a: MP:0002896 ! abnormal bone mineralization

[Term]
id: MP:0003118
name: obsolete abnormal tracheal-bronchial branching morphogenesis
def: "OBSOLETE. partial or complete failure of the trachea and bronchi to repeatedly divide during development of the lung" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true
consider: MP:0011024
consider: MP:0011025
consider: MP:0011027

[Term]
id: MP:0003119
name: abnormal digestive system development
def: "abnormal formation of the organ system that converts ingested food to nutrients and energy" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003120
name: abnormal tracheal cartilage morphology
def: "any structural anomaly of the cartilaginous structures that support the trachea and prevent it from collapsing" [https://orcid.org/0000-0003-4606-0597, J:97123]
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0003121
name: genetic imprinting
def: "the process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0071514]
synonym: "genomic imprinting" EXACT []
is_a: MP:0005384 ! cellular phenotype

[Term]
id: MP:0003122
name: maternal imprinting
def: "the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the maternal germline, but that are not encoded by DNA itself" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003121 ! genetic imprinting

[Term]
id: MP:0003123
name: paternal imprinting
def: "establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal germline, but that are not encoded by DNA itself" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003121 ! genetic imprinting

[Term]
id: MP:0003124
name: hypospadia
def: "a urethral opening located below the normal location; in males, the abnormally placed opening is usually on the ventral surface of the penis, and in females, the abnormally placed opening is usually in the vagina" [ISBN:0683400088]
subset: CvDC_Terms
synonym: "hypospadias" EXACT []
synonym: "hypospadis" EXACT []
xref: Fyler:4504
is_a: MP:0011796 ! abnormal external urethral orifice morphology

[Term]
id: MP:0003125
name: abnormal septation of the cloaca
def: "absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into multiple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca" [https://orcid.org/0000-0003-4606-0597, J:91491]
is_a: MP:0010115 ! abnormal embryonic cloaca morphology

[Term]
id: MP:0003126
name: abnormal external female genitalia morphology
def: "any structural anomaly of the external feminine genital organs, collectively known as the vulva and composed of the mons pubis, the labia majora and minora, the clitoris, the vestibule of the vagina and its glands, and the opening of the urethra and of the vagina" [https://orcid.org/0000-0002-6490-7723]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cunnus morphology" EXACT []
synonym: "abnormal external female genital organs morphology" EXACT []
synonym: "abnormal external female genitals" RELATED []
synonym: "abnormal organa genitalia feminina externa" RELATED []
synonym: "abnormal vulva morphology" EXACT []
synonym: "vulva dysplasia" NARROW []
synonym: "vulval defects" NARROW []
is_a: MP:0009208 ! abnormal female genitalia morphology

[Term]
id: MP:0003127
name: abnormal clitoris morphology
def: "any structural anomaly of the small, erectile body located at the anterior end of the vulva" [ISBN:0-683-40008-8]
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0003128
name: splayed clitoris
def: "flattened or spread out clitoris" [https://orcid.org/0000-0003-4606-0597, J:91491]
is_a: MP:0003127 ! abnormal clitoris morphology

[Term]
id: MP:0003129
name: persistent cloaca
def: "persistence of an early embryonic state in which the urinary, genital, and gastrointestinal tracts remain confluent and communicate with the exterior through a single perineal opening; due to failure of the urogenital septum to divide the embryonic cloaca into rectal and urogenital portions" [https://orcid.org/0000-0002-6490-7723]
comment: Note that the term "urogenital sinus" may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal.
synonym: "cloacogenic bladder" EXACT []
synonym: "congenital cloaca" EXACT []
synonym: "urogenital sinus" RELATED []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
is_a: MP:0003119 ! abnormal digestive system development
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0003130
name: anal atresia
def: "congenital absence of an anal opening due to the persistence of the epithelial plug (persistence of the anal membrane) or to complete absence of the anal canal" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
synonym: "atresia ani" EXACT []
synonym: "imperforate anus" EXACT []
synonym: "proctatresia" EXACT []
xref: Fyler:4402
xref: Fyler:4443
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0003131
name: increased erythrocyte cell number
def: "greater number of the cells that transport oxygen, red blood cells, per unit" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased definitive erythrocyte cell number" RELATED []
synonym: "increased erythrocyte count" EXACT []
is_a: MP:0001586 ! abnormal erythrocyte cell number
is_a: MP:0013663 ! increased myeloid cell number

[Term]
id: MP:0003132
name: increased pre-B cell number
def: "greater number of progenitor cells that form the B cell component of the immune system" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8153-1691-7]
synonym: "increased number of pre-B cells" EXACT []
is_a: MP:0002403 ! abnormal pre-B cell morphology
is_a: MP:0005014 ! increased B cell number

[Term]
id: MP:0003133
name: increased early pro-B cell number
def: "greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8153-1691-7]
synonym: "increased number of early pro-B cells" EXACT []
is_a: MP:0005019 ! abnormal early pro-B cell
is_a: MP:0008186 ! increased pro-B cell number

[Term]
id: MP:0003134
name: increased late pro-B cell number
def: "greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8153-1691-7]
synonym: "increased number of late pro-B cells" EXACT []
is_a: MP:0005020 ! abnormal late pro-B cell
is_a: MP:0008186 ! increased pro-B cell number

[Term]
id: MP:0003135
name: increased erythroid progenitor cell number
def: "greater numbers of progenitors of the erythrocyte lineage" [CL:0000038, https://orcid.org/0000-0003-4606-0597]
synonym: "increased BFU-E number" RELATED []
synonym: "increased blast forming unit erythroid number" RELATED []
synonym: "increased burst forming unit erythroid number" RELATED []
synonym: "increased CFU-E number" RELATED []
synonym: "increased colony forming unit erythroid number" RELATED []
synonym: "increased erythroid precursors" EXACT []
synonym: "increased erythroid stem cell number" RELATED []
is_a: MP:0008801 ! abnormal erythroid progenitor cell morphology

[Term]
id: MP:0003136
name: yellow coat color
def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is maximally increased in agouti hair" [MGI:llw2]
comment: This term is rodent specific.
synonym: "yellow coat colour" EXACT []
is_a: MP:0012076 ! abnormal agouti pigmentation

[Term]
id: MP:0003137
name: abnormal impulse conducting system conduction
def: "any functional anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [MESH:A07.541.409, MGI:hdene]
synonym: "abnormal bundle of Kent conduction" EXACT []
synonym: "abnormal cardiac muscle conduction" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0003138
name: absent tympanic ring
def: "missing the bony ring at the ear canal to which the tympanic membrane is attached" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000030 ! abnormal tympanic ring morphology

[Term]
id: MP:0003139
name: patent ductus arteriosus
def: "failure of the fetal connection between the aorta and pulmonary artery to close after birth" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "dominant ductus arteriosus" EXACT []
synonym: "patent arterial duct" EXACT []
synonym: "PDA" EXACT []
synonym: "persistent ductus arteriosus" EXACT []
xref: Fyler:2100
is_a: MP:0000364 ! abnormal vascular regression
is_a: MP:0010564 ! abnormal fetal ductus arteriosus morphology

[Term]
id: MP:0003140
name: dilated heart atrium
def: "the luminal space of one or both of the upper chambers of the heart is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-4606-0597]
synonym: "atria dilation" EXACT []
synonym: "atrial dilation" EXACT []
synonym: "cardiac atrium dilation" EXACT []
synonym: "dilated atria" EXACT []
synonym: "dilated cardiac atria" EXACT []
synonym: "dilated cardiac atrium" EXACT []
synonym: "dilated heart atria" EXACT []
synonym: "heart atrium dilation" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0004937 ! dilated heart

[Term]
id: MP:0003141
name: cardiac fibrosis
def: "formation of fibrous tissue within the heart often resulting from inflammation or injury" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0003142
name: anotia
def: "congenital absence of one or both auricles of the ears" [https://orcid.org/0000-0002-6490-7723, PMID:10471511]
is_a: MP:0005579 ! absent outer ear

[Term]
id: MP:0003143
name: enlarged otoliths
def: "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [https://orcid.org/0000-0002-6490-7723, PMID:11152663]
synonym: "enlarged ear crystals" EXACT []
synonym: "enlarged otoconial crystals" EXACT []
synonym: "enlarged statoconia" EXACT []
synonym: "enlarged statoliths" EXACT []
synonym: "giant otoconia" EXACT []
synonym: "increased otolith size" EXACT []
is_a: MP:0002894 ! abnormal otolith morphology

[Term]
id: MP:0003144
name: decreased otolith number
def: "reduced average number of the crystalline calciferous particles adhering to the otolithic membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased number of otoliths" EXACT []
synonym: "decreased otoconial crystal number" EXACT []
synonym: "reduced number of otoconia" EXACT []
synonym: "reduced number of otoliths" EXACT []
synonym: "reduced otolith number" EXACT []
is_a: MP:0002894 ! abnormal otolith morphology

[Term]
id: MP:0003145
name: detached otolithic membrane
def: "part or all of the otolithic (otoconial) membrane is abnormally separated from the sensory epithelium (macula) of the utricle and/or saccule" [https://orcid.org/0000-0002-6490-7723, PMID:22116368]
synonym: "detached octoconial membrane" EXACT []
synonym: "detached otolithic part of statoconial membrane" EXACT []
is_a: MP:0002895 ! abnormal otolithic membrane morphology

[Term]
id: MP:0003146
name: absent cochlear ganglion
def: "absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "absent cochlear ganglia" EXACT []
synonym: "absent spiral ganglion" EXACT []
is_a: MP:0002855 ! abnormal cochlear ganglion morphology

[Term]
id: MP:0003147
name: absent cochlea
def: "absence or agenesis of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003148
name: decreased cochlea coiling
def: "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cochlear coiling" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003149
name: abnormal tectorial membrane morphology
def: "any structural anomaly of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0003150
name: detached tectorial membrane
def: "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0003151
name: absent tunnel of Corti
def: "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013808 ! abnormal tunnel of Corti morphology

[Term]
id: MP:0003152
name: abnormal pillar cell differentiation
def: "abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003825 ! abnormal pillar cell morphology
is_a: MP:0008304 ! abnormal organ of Corti supporting cell differentiation

[Term]
id: MP:0003153
name: early eyelid opening
def: "early average time for the first postnatal eye opening" [https://orcid.org/0000-0003-4606-0597, J:92240]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later.
synonym: "early eye lid opening" EXACT []
is_a: MP:0004874 ! abnormal timing of postnatal eyelid opening

[Term]
id: MP:0003154
name: abnormal soft palate morphology
def: "any structural anomaly of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal velum" EXACT []
synonym: "abnormal velum palatinum" EXACT []
is_a: MP:0013550 ! abnormal secondary palate morphology

[Term]
id: MP:0003155
name: abnormal telomere length
def: "abnormal length of the terminal repetitive DNA section of a chromosome that is involved in chromosomal replication and senescence and protects the end of the chromosome from deterioration; normal length is a few hundred base pairs" [https://orcid.org/0000-0003-3691-0324, MGI:hdene]
is_a: MP:0010207 ! abnormal telomere morphology

[Term]
id: MP:0003156
name: abnormal leukocyte migration
def: "altered ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV" [GO:0050900, MGI:acv]
synonym: "abnormal leucocyte homing" NARROW []
synonym: "abnormal leucocyte migration" EXACT []
synonym: "abnormal leucocyte trafficking" EXACT []
synonym: "abnormal leukocyte homing" NARROW []
synonym: "abnormal leukocyte trafficking" EXACT []
synonym: "abnormal lymphocyte migration/homing" NARROW []
is_a: MP:0002442 ! abnormal leukocyte physiology
is_a: MP:0003091 ! abnormal cell migration

[Term]
id: MP:0003157
name: impaired muscle relaxation
def: "reduced or absent ability of muscle to lengthen following contractions" [https://orcid.org/0000-0003-4606-0597, J:92510]
synonym: "myotonia" RELATED []
is_a: MP:0004036 ! abnormal muscle relaxation

[Term]
id: MP:0003158
name: dysphagia
def: "difficulty in swallowing food or liquid" [ISBN:0-683-40008-8]
synonym: "impaired swallowing" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0005449 ! abnormal food intake

[Term]
id: MP:0003159
name: abnormal esophageal smooth muscle morphology
def: "any structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal oesophageal smooth muscle morphology" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0000767 ! abnormal smooth muscle morphology

[Term]
id: MP:0003160
name: abnormal esophagus development
def: "aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal esophageal development" EXACT []
synonym: "abnormal oesophageal development" EXACT []
synonym: "abnormal oesophagus development" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0003119 ! abnormal digestive system development

[Term]
id: MP:0003161
name: absent lateral semicircular canal
def: "absence of the lateral long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000037 ! abnormal lateral semicircular canal morphology

[Term]
id: MP:0003162
name: decreased lateral semicircular canal size
def: "small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased size of lateral semicircular canal" EXACT []
synonym: "reduced size of lateral semicircular canal" EXACT []
is_a: MP:0000037 ! abnormal lateral semicircular canal morphology

[Term]
id: MP:0003163
name: absent posterior semicircular canal
alt_id: MP:0003676
def: "absence of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723]
synonym: "aplasia of posterior semicircular canal" EXACT []
is_a: MP:0002858 ! abnormal posterior semicircular canal morphology

[Term]
id: MP:0003164
name: decreased posterior semicircular canal size
def: "small size of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased size of posterior semicircular canal" RELATED []
synonym: "reduced posterior semicircular canal size" EXACT []
synonym: "reduced size of posterior semicircular canal" EXACT []
is_a: MP:0002858 ! abnormal posterior semicircular canal morphology

[Term]
id: MP:0003165
name: absent superior semicircular canal
def: "absence of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [ISBN:0-683-40008-8]
synonym: "absent anterior semicircular canal" EXACT []
is_a: MP:0003069 ! abnormal superior semicircular canal morphology

[Term]
id: MP:0003166
name: decreased superior semicircular canal size
def: "small size of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [ISBN:0-683-40008-8]
synonym: "decreased size of superior semicircular canal" RELATED []
synonym: "reduced size of anterior semicircular canal" EXACT []
synonym: "reduced size of superior semicircular canal" EXACT []
is_a: MP:0003069 ! abnormal superior semicircular canal morphology

[Term]
id: MP:0003167
name: abnormal scala tympani morphology
def: "any structural anomaly of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003168
name: abnormal scala vestibuli morphology
def: "any structural anomaly of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal perilymphatic space" EXACT []
synonym: "abnormal vestibular canal" EXACT []
synonym: "abnormal vestibular chamber" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003169
name: abnormal scala media morphology
def: "any structural anomaly of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [https://orcid.org/0000-0002-6490-7723, PMID:1680563]
synonym: "abnormal cochlear chamber" EXACT []
synonym: "abnormal cochlear duct morphology" EXACT []
synonym: "abnormal Lowenberg scala" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology
is_a: MP:0004426 ! abnormal cochlear labyrinth morphology

[Term]
id: MP:0003171
name: phenotypic reversion
def: "wild-type phenotype restored from a previously characterized mutant phenotype" [MGI:llw2]
synonym: "phenotypic instability" EXACT []
synonym: "revertant" EXACT []
is_a: MP:0002873 ! normal phenotype

[Term]
id: MP:0003172
name: abnormal lysosome physiology
def: "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [MGI:llw2]
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0003173
name: decreased lysosomal enzyme secretion
def: "production or release of glycoprotein hydrolytic enzymes is decreased compared to normal" [MGI:llw2]
synonym: "reduced lysosomal enzyme secretion" EXACT []
is_a: MP:0003172 ! abnormal lysosome physiology

[Term]
id: MP:0003174
name: increased lysosomal enzyme secretion
def: "production or secretion of glycoprotein hydrolytic enzymes is increased compared to normal" [MGI:llw2]
is_a: MP:0003172 ! abnormal lysosome physiology

[Term]
id: MP:0003175
name: reversion by mitotic recombination
def: "cross-over event between sequences containing mutant and wild-type alleles during DNA replication in a heterozygote resulting in cells with two wild-type alleles" [MGI:llw2]
is_a: MP:0003171 ! phenotypic reversion

[Term]
id: MP:0003176
name: reversion by viral sequence excision
def: "restoration of wild-type phenotype by removal of a viral sequence or a viral- related sequence that produced a mutant phenotype" [MGI:llw2]
is_a: MP:0003171 ! phenotypic reversion

[Term]
id: MP:0003177
name: allodynia
def: "condition in which nonpainful stimuli evoke a pain sensation" [ISBN:0-683-40008-8]
is_a: MP:0001970 ! abnormal pain threshold

[Term]
id: MP:0003178
name: left pulmonary isomerism
def: "anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the left side of the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000542 ! left-sided isomerism
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010853 ! abnormal lung position or orientation

[Term]
id: MP:0003179
name: thrombocytopenia
alt_id: MP:0002749
def: "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [https://orcid.org/0000-0003-3691-0324, MGI:hdene]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased platelet cell number" EXACT []
synonym: "decreased platelet count" RELATED []
synonym: "decreased thrombocyte number" EXACT []
synonym: "reduced platelet count" EXACT []
synonym: "thrombopenia" EXACT []
is_a: MP:0011898 ! abnormal platelet cell number
is_a: MP:0013662 ! decreased myeloid cell number

[Term]
id: MP:0003180
name: abnormal pulmonary endothelial cell surface
def: "altered morphology or area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell" [RGD:cur]
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0004007 ! abnormal lung vasculature morphology
is_a: MP:0006055 ! abnormal vascular endothelial cell morphology

[Term]
id: MP:0003181
name: increased pulmonary endothelial cell surface
def: "increased total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell" [RGD:cur]
is_a: MP:0003180 ! abnormal pulmonary endothelial cell surface

[Term]
id: MP:0003182
name: decreased pulmonary endothelial cell surface
def: "reduced total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell" [RGD:cur]
synonym: "reduced pulmonary endothelial cell surface" EXACT []
is_a: MP:0003180 ! abnormal pulmonary endothelial cell surface

[Term]
id: MP:0003183
name: obsolete abnormal peptide metabolism
def: "anomaly in the biochemical modification and homeostasis of molecules consisting of linked amino acids and their derivatives" [RGD:cur]
comment: Removing duplicate term.
is_obsolete: true
replaced_by: MP:0013246

[Term]
id: MP:0003184
name: increased angiotensin I-converting enzyme activity
def: "greater activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin" [RGD:cur]
synonym: "increased ACE activity" EXACT []
is_a: MP:0013254 ! abnormal angiotensin I-converting enzyme activity

[Term]
id: MP:0003185
name: decreased angiotensin I-converting enzyme activity
def: "reduced activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin" [RGD:cur]
synonym: "decreased ACE activity" EXACT []
synonym: "reduced angiotensin I-converting enzyme activity" EXACT []
is_a: MP:0013254 ! abnormal angiotensin I-converting enzyme activity

[Term]
id: MP:0003186
name: abnormal redox activity
def: "any anomaly in the processes that maintain the redox environment of a cell or compartment within a cell" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0003187
name: obsolete increased reduction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0003188
name: obsolete decreased reduction
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0003189
name: fused joints
def: "partial or complete absence of a functional articulation point of two or more bones" [https://orcid.org/0000-0003-3691-0324]
synonym: "fusion of joints" EXACT []
synonym: "joint fusion" EXACT []
is_a: MP:0002932 ! abnormal joint morphology

[Term]
id: MP:0003190
name: fused synovial joints
def: "partial or complete absence of separations containing synovial fluid between bones" [https://orcid.org/0000-0003-4606-0597]
synonym: "fusion of synovial joints" EXACT []
synonym: "synovial joint fusion" EXACT []
is_a: MP:0003189 ! fused joints
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0003191
name: abnormal cellular cholesterol metabolism
def: "impaired regulation of cellular cholesterol levels" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005621 ! abnormal cell physiology
is_a: MP:0013245 ! abnormal lipid metabolism

[Term]
id: MP:0003192
name: increased cholesterol efflux
def: "greater level of removal of excess cholesterol from cells by an active transport pathway" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
is_a: MP:0003191 ! abnormal cellular cholesterol metabolism

[Term]
id: MP:0003193
name: decreased cholesterol efflux
def: "reduced level of removal of excess cholesterol from cells by an active transport pathway" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "reduced cholesterol efflux" EXACT []
is_a: MP:0003191 ! abnormal cellular cholesterol metabolism

[Term]
id: MP:0003194
name: abnormal frequency of paradoxical sleep
def: "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "abnormal frequency of rapid eye movement sleep" EXACT []
synonym: "abnormal frequency of REM sleep" EXACT []
is_a: MP:0012288 ! abnormal paradoxical sleep pattern

[Term]
id: MP:0003195
name: calcinosis
def: "pathologic deposition of calcium salts in tissues" [MESH:C18.452.174.130, RGD:cur]
is_a: MP:0004231 ! abnormal calcium ion homeostasis

[Term]
id: MP:0003196
name: calcified skin
def: "pathologic deposition of calcium salts in the skin" [RGD:cur]
synonym: "skin calcification" EXACT []
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0003197
name: nephrocalcinosis
def: "diffusely scattered foci of calcification in the renal parenchyma, with microscopic or macroscopic deposits of calcium salts" [MESH:C12.777.419.590, RGD:cur]
synonym: "calcified kidney" EXACT []
synonym: "kidney calcification" BROAD []
synonym: "renal calcification" BROAD []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003198
name: calcified tendon
def: "pathologic deposition of calcium salts in the tendons" [RGD:cur]
synonym: "tendon calcification" BROAD []
is_a: MP:0005503 ! abnormal tendon morphology

[Term]
id: MP:0003199
name: calcified muscle
def: "pathologic deposition of calcium salts in muscle" [RGD:cur]
synonym: "muscle calcification" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0003200
name: calcified joint
def: "pathologic deposition of calcium salts in the joints" [RGD:cur]
synonym: "joint calcification" BROAD []
is_a: MP:0002932 ! abnormal joint morphology

[Term]
id: MP:0003201
name: extremity edema
def: "an accumulation of serous fluid in the limbs, paws and tail" [RGD:cur]
synonym: "extremity oedema" EXACT []
is_a: MP:0001785 ! edema

[Term]
id: MP:0003202
name: abnormal neuron apoptosis
def: "change in the timing or the number of neurons undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neuronal apoptosis" EXACT []
synonym: "abnormal neuronal cell death" RELATED []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0004811 ! abnormal neuron physiology

[Term]
id: MP:0003203
name: increased neuron apoptosis
def: "increase in the number of neurons undergoing programmed cell death" [RGD:cur]
synonym: "increased neuronal apoptosis" EXACT []
synonym: "increased neuronal cell death" EXACT []
is_a: MP:0003202 ! abnormal neuron apoptosis
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0003204
name: decreased neuron apoptosis
def: "decrease in the number of neurons undergoing programmed cell death" [RGD:cur]
synonym: "decreased neuronal apoptosis" EXACT []
synonym: "decreased neuronal cell death" RELATED []
synonym: "reduced neuronal apoptosis" EXACT []
synonym: "reduced neuronal cell death" RELATED []
is_a: MP:0003202 ! abnormal neuron apoptosis
is_a: MP:0006043 ! decreased apoptosis

[Term]
id: MP:0003205
name: testicular atrophy
def: "acquired diminution of the size of the testis associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "testis atrophy" EXACT []
is_a: MP:0001147 ! small testis

[Term]
id: MP:0003207
name: decreased cellular sensitivity to gamma-irradiation
def: "decreased incidence of cell death following exposure to gamma-irradiation" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cellular susceptibility to gamma-irradiation" EXACT []
synonym: "increased cellular resistance to gamma-irradiation" EXACT []
synonym: "reduced cellular sensitivity to gamma-irradiation" EXACT []
is_a: MP:0004228 ! decreased cellular sensitivity to ionizing radiation

[Term]
id: MP:0003208
name: abnormal neuromere morphology
def: "any structural anomaly of the segments of the developing neural tube" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0003209
name: abnormal pulmonary elastic fiber morphology
def: "any structural anomaly of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [ISBN:0-683-40008-8, RGD:cur]
synonym: "abnormal pulmonary elastic fibre morphology" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0003210
name: abnormal heart elastic fiber morphology
def: "any structural anomaly of the slender connective tissue fiber in cardiac tissue characterized by great elasticity" [ISBN:0-683-40008-8, RGD:cur]
synonym: "abnormal cardiac elastic fiber morphology" EXACT []
synonym: "abnormal cardiac elastic fibre morphology" EXACT []
synonym: "abnormal heart elastic fibre morphology" EXACT []
is_a: MP:0009863 ! abnormal heart elastic tissue morphology

[Term]
id: MP:0003211
name: abnormal aorta elastic fiber morphology
def: "any structural anomaly of the slender connective tissue fiber in aortic tissue characterized by great elasticity" [ISBN:0-683-40008-8, RGD:cur]
synonym: "abnormal aorta elastic fibre morphology" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009862 ! abnormal aorta elastic tissue morphology

[Term]
id: MP:0003212
name: increased susceptibility to age related obesity
def: "increased probability of excessive weight gain that is progressive with age" [RGD:cur]
synonym: "decreased resistance to age related obesity" EXACT []
is_a: MP:0005455 ! increased susceptibility to weight gain

[Term]
id: MP:0003213
name: decreased susceptibility to age related obesity
def: "reduced probability of excessive weight gain that is progressive with age" [RGD:cur]
synonym: "increased resistance to age related obesity" EXACT []
is_a: MP:0010182 ! decreased susceptibility to weight gain

[Term]
id: MP:0003214
name: neurofibrillary tangles
def: "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies" [GO:0097418, https://www.ncbi.nlm.nih.gov/mesh/68016874, ISBN:0-683-40008-8, RGD:cur]
synonym: "neuritic plaques" RELATED []
synonym: "senile plaques" RELATED []
synonym: "tau protein tangles" EXACT []
is_a: MP:0004250 ! tau protein deposits

[Term]
id: MP:0003215
name: renal interstitial fibrosis
def: "formation of fibrous tissue within the functional space in the kidney beneath the individual filters (glomeruli) as a result of repair or a reactive process" [RGD:cur]
is_a: MP:0003985 ! renal fibrosis
is_a: MP:0011425 ! abnormal kidney interstitium morphology

[Term]
id: MP:0003216
name: absence seizures
def: "impairment of consciousness without convulsions associated with sudden behavioral arrest and widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [PMID:16725200, RGD:cur]
synonym: "absence epilepsy" EXACT []
synonym: "spike wave seizures" EXACT []
synonym: "spike-wave seizures" EXACT []
is_a: MP:0000948 ! nonconvulsive seizures

[Term]
id: MP:0003217
name: increased spike-wave discharge type I
def: "increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than spike-wave discharge type II" [RGD:cur]
is_a: MP:0008840 ! abnormal spike wave discharge

[Term]
id: MP:0003218
name: decreased spike-wave discharge type I
def: "decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than Spike-wave discharge type II" [RGD:cur]
synonym: "reduced spike-wave discharge type I" EXACT []
is_a: MP:0008840 ! abnormal spike wave discharge

[Term]
id: MP:0003219
name: increased spike-wave discharge type II
def: "increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I" [RGD:cur]
is_a: MP:0008840 ! abnormal spike wave discharge

[Term]
id: MP:0003220
name: decreased spike-wave discharge type II
def: "decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I" [RGD:cur]
synonym: "reduced spike-wave discharge type II" EXACT []
is_a: MP:0008840 ! abnormal spike wave discharge

[Term]
id: MP:0003221
name: abnormal cardiomyocyte apoptosis
def: "change in the timing or the number of cardiac muscle cells undergoing programmed cell death" [RGD:cur]
comment: Note that this is a generic term that applies to cardiomyocytes irrespective of the life stage of the organism, that is, regardless of whether cardiac muscle cells are still in the process of differentiation or terminally differentiated.
synonym: "abnormal cardiac muscle cell apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0003222
name: increased cardiomyocyte apoptosis
def: "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:cur]
synonym: "elevated cardiac muscle cell apoptosis" EXACT []
synonym: "elevated cardiomyocyte apoptosis" EXACT []
synonym: "increased cardiac muscle cell apoptosis" EXACT []
is_a: MP:0003221 ! abnormal cardiomyocyte apoptosis
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0003223
name: decreased cardiomyocyte apoptosis
def: "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:cur]
synonym: "decreased cardiac muscle cell apoptosis" EXACT []
synonym: "reduced cardiac muscle cell apoptosis" EXACT []
synonym: "reduced cardiomyocyte apoptosis" EXACT []
is_a: MP:0003221 ! abnormal cardiomyocyte apoptosis
is_a: MP:0006043 ! decreased apoptosis

[Term]
id: MP:0003224
name: neuron degeneration
def: "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses" [ISBN:0-683-40008-8]
is_a: MP:0002229 ! neurodegeneration
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0003225
name: axonal dystrophy
def: "axon degeneration that may result from genetic abnormalities or inadequate or faulty metabolism" [RGD:cur]
is_a: MP:0005405 ! axon degeneration

[Term]
id: MP:0003226
name: absent cochlear modiolus
def: "absence of the central cone shaped core of spongy bone about which turns the spiral canal" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0003309 ! abnormal cochlear modiolus morphology

[Term]
id: MP:0003227
name: abnormal vascular branching morphogenesis
def: "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000260 ! abnormal angiogenesis

[Term]
id: MP:0003228
name: abnormal sinus venosus morphology
def: "any structural anomaly of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sinus venosus" BROAD []
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0003229
name: abnormal vitelline vasculature morphology
def: "any structural anomaly of the vascular network that supplies the yolk sac" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal omphalomesenteric vasculature" EXACT []
synonym: "abnormal yolk sac vasculature" EXACT []
is_a: MP:0000259 ! abnormal vascular development
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0003230
name: abnormal umbilical artery morphology
def: "any structural anomaly of the paired arteries that bring unoxygenated blood back to the placenta from the dorsal aorta through the umbilical cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003410 ! abnormal artery development
is_a: MP:0012300 ! abnormal umbilical cord blood vessel morphology

[Term]
id: MP:0003231
name: abnormal placenta vasculature
def: "any structural anomaly of the vessels of the placenta" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "abnormal placental vasculature" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0003232
name: abnormal forebrain development
def: "anomaly in the formation or patterning of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
subset: IMPC_Prenatal
synonym: "abnormal prosencephalon development" EXACT []
is_a: MP:0000783 ! abnormal forebrain morphology
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0003233
name: prolonged QT interval
def: "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave" [https://orcid.org/0000-0003-4606-0597, PMID:12114851]
comment: A prolonged QT interval is a risk factor for ventricular tachyarrhythmias and sudden death. It varies with heart rate and for clinical relevance requires a correction for this, giving the QTc.
synonym: "increased QT interval" EXACT []
synonym: "long QT syndrome" RELATED []
synonym: "widened QT interval" EXACT []
is_a: MP:0003899 ! abnormal QT interval

[Term]
id: MP:0003234
name: enhanced NMDA-mediated synaptic currents
def: "increase in the measured amplitude, current density or duration of response to stimulation of NMDA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002888 ! abnormal NMDA-mediated synaptic currents

[Term]
id: MP:0003235
name: abnormal alisphenoid bone morphology
def: "any structural anomaly of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal great wing of the sphenoid bone" EXACT []
synonym: "abnormal greater wing of the sphenoid bone" EXACT []
is_a: MP:0000104 ! abnormal sphenoid bone morphology

[Term]
id: MP:0003236
name: abnormal lens capsule morphology
def: "any structural anomaly of the elastic, clear, membrane-like structure, that is outer most layer of the lens" [https://orcid.org/0000-0003-4606-0597, PMID:15483628]
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0003237
name: abnormal lens epithelium morphology
def: "any structural anomaly in the one or more of the layers of epithelial cells in the lens" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0003238
name: slow REM
def: "decreased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place" [RGD:cur]
synonym: "slow rapid eye movement" EXACT []
is_a: MP:0012288 ! abnormal paradoxical sleep pattern

[Term]
id: MP:0003239
name: fast REM
def: "increased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place" [RGD:cur]
synonym: "fast rapid eye movement" EXACT []
is_a: MP:0012288 ! abnormal paradoxical sleep pattern

[Term]
id: MP:0003240
name: loss of hippocampal neurons
def: "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:cur]
is_a: MP:0009939 ! abnormal hippocampus neuron morphology

[Term]
id: MP:0003241
name: loss of cortex neurons
def: "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:cur]
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0003242
name: loss of basal ganglia neurons
def: "loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event" [RGD:cur]
is_a: MP:0006007 ! abnormal basal ganglion morphology

[Term]
id: MP:0003243
name: abnormal dopaminergic neuron morphology
def: "any structural anomaly of the neurons that utilize dopamine as a neurotransmitter" [ISBN:0838580343]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0003244
name: loss of dopaminergic neurons
def: "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:cur]
is_a: MP:0003243 ! abnormal dopaminergic neuron morphology

[Term]
id: MP:0003245
name: abnormal GABAergic neuron morphology
def: "any structural anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [ISBN:0838580343]
synonym: "abnormal GABA neuron morphology" RELATED []
synonym: "abnormal GABA neurons" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0003246
name: loss of GABAergic neurons
def: "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:cur]
synonym: "loss of GABA neurons" EXACT []
is_a: MP:0003245 ! abnormal GABAergic neuron morphology

[Term]
id: MP:0003247
name: abnormal glutaminergic neuron morphology
def: "any structural anomaly of the neurons that utilize glutamate as a neurotransmitter" [ISBN:0838580343]
synonym: "abnormal glutamatergic neuron morphology" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0003248
name: loss of glutamate neurons
def: "loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event" [RGD:cur]
is_a: MP:0003247 ! abnormal glutaminergic neuron morphology

[Term]
id: MP:0003249
name: increased muscle free fatty acids level
def: "greater than normal muscle concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues" [ISBN:0-683-40008-8, RGD:cur]
synonym: "elevated muscle free fatty acid (FFA)" EXACT []
synonym: "increased muscle free fatty acid level" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0005281 ! increased fatty acids level
is_a: MP:0010358 ! abnormal free fatty acids level

[Term]
id: MP:0003250
name: absent gallbladder
def: "absence of the organ which serves as a storage reservoir for bile" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "absent cholecyst" EXACT []
synonym: "absent gall bladder" EXACT []
is_a: MP:0005084 ! abnormal gallbladder morphology

[Term]
id: MP:0003251
name: gallbladder inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the gall bladder" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "gall bladder inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005085 ! abnormal gallbladder physiology

[Term]
id: MP:0003252
name: abnormal bile duct physiology
def: "any functional anomaly of the channels that secrete bile from the liver to the gall bladder and intestines" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0002139 ! abnormal hepatobiliary system physiology

[Term]
id: MP:0003253
name: dilated bile duct
def: "the luminal space of one or more bile ducts is increased in volume or area, usually with an increase in contained fluid or bile" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
synonym: "bile duct dilation" EXACT []
synonym: "dilated bile ducts" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0003254
name: bile duct inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "cholangitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003252 ! abnormal bile duct physiology

[Term]
id: MP:0003255
name: bile duct proliferation
def: "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [NCBI:matt]
synonym: "increased bile duct number" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0003256
name: biliary cirrhosis
def: "liver damage to parenchymal cells due to obstruction of bile flow in the bile ducts" [MESH:C06.130.120.135.250.250, NCBI:matt]
is_a: MP:0003252 ! abnormal bile duct physiology

[Term]
id: MP:0003257
name: abnormal abdominal wall morphology
def: "any structural anomaly of the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MESH:A01.047.050, NCBI:matt]
is_a: MP:0003385 ! abnormal body wall morphology

[Term]
id: MP:0003258
name: hiatal hernia
def: "protrusion of abdominal structures through the esophageal hiatus of the diaphragm" [ISBN:0-683-40008-8, MESH:C23.300.707.500.467, NCBI:matt]
is_a: MP:0003257 ! abnormal abdominal wall morphology

[Term]
id: MP:0003259
name: nausea
def: "gastric discomfort associated with the inclination to vomit" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0001664 ! abnormal digestion

[Term]
id: MP:0003260
name: vomiting
def: "the retrograde expulsion of gastric contents through the oral cavity" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0001664 ! abnormal digestion

[Term]
id: MP:0003261
name: hematemesis
def: "vomiting of blood; indicative of bleeding in the upper gastrointestinal tract" [MESH:C06.405.227.400, NCBI:matt]
synonym: "vomiting blood" EXACT []
is_a: MP:0003260 ! vomiting

[Term]
id: MP:0003262
name: intestinal/bowel diverticulum
def: "a pouch or sac protruding from the intestinal or bowel wall" [NCBI:matt]
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0003263
name: obsolete abnormal cholesterol biosynthesis
def: "OBSOLETE. altered ability to form cholesterol from constituent compounds" [NCBI:matt]
is_obsolete: true

[Term]
id: MP:0003264
name: obsolete increased cholesterol biosynthesis
def: "OBSOLETE. augmented rate at which cholesterol is formed from constituent compounds" [NCBI:matt]
is_obsolete: true

[Term]
id: MP:0003265
name: obsolete decreased cholesterol biosynthesis
def: "OBSOLETE. reduced rate at which cholesterol is formed from constituent compounds" [NCBI:matt]
is_obsolete: true

[Term]
id: MP:0003266
name: biliary cyst
def: "presence of one or more abnormal fluid-filled sacs within the bile ducts" [NCBI:matt]
synonym: "biliary cysts" EXACT []
synonym: "choledochal cyst" EXACT []
synonym: "choledochal cysts" EXACT []
synonym: "choledochocele" EXACT []
synonym: "choledochoceles" EXACT []
synonym: "common bile duct cyst" EXACT []
synonym: "common bile duct cysts" EXACT []
synonym: "cystic bile duct" EXACT []
synonym: "cystic bile ducts" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003267
name: constipation
def: "incomplete, infrequent or difficult evacuation of fecal matter" [MESH:C23.888.821.150, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0003866 ! abnormal defecation

[Term]
id: MP:0003268
name: chronic constipation
def: "prolonged or long-term difficulty in evacuation of fecal matter" [MESH:C23.888.821.150, NCBI:matt]
is_a: MP:0003267 ! constipation

[Term]
id: MP:0003269
name: colon polyps
def: "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [MESH:C23.300.825.411.235, NCBI:matt]
synonym: "colonic polyps" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0008011 ! intestine polyps

[Term]
id: MP:0003270
name: intestinal obstruction
def: "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus" [MESH:C06.405.469.531, NCBI:matt]
is_a: MP:0011082 ! abnormal gastrointestinal motility

[Term]
id: MP:0003271
name: abnormal duodenum morphology
def: "any structural anomaly of the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MESH:A03.556.124.684.124]
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0003272
name: duodenal atresia
def: "congenital blockage or absence of the lumen of the duodenum" [MESH:C06.198.719, NCBI:matt]
subset: CvDC_Terms
xref: Fyler:4406
is_a: MP:0003271 ! abnormal duodenum morphology

[Term]
id: MP:0003273
name: duodenal ulcer
def: "a lesion on the mucosal surface of the duodenum, usually produced by the sloughing of inflammatory necrotic tissue" [MESH:C23.550.891, NCBI:matt]
synonym: "Curling ulcer" EXACT []
is_a: MP:0003271 ! abnormal duodenum morphology
is_a: MP:0003301 ! peptic ulcer

[Term]
id: MP:0003274
name: intestinal microaneurysm
def: "focal dilation of arteriocapillary junctions in the intestine" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0003279 ! aneurysm

[Term]
id: MP:0003275
name: gastric microaneurysm
def: "focal dilation of arteriocapillary junctions in the stomach" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0003279 ! aneurysm

[Term]
id: MP:0003276
name: esophageal atresia
def: "congenital blockage or absence of the lumen of the esophagus" [MESH:C06.198.330, NCBI:matt]
subset: CvDC_Terms
synonym: "oesophageal atresia" EXACT []
xref: Fyler:4412
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0003277
name: increased esophageal papilloma incidence
def: "higher than normal incidence of a benign epithelial tumor consisting of villous or arborescent outgrowths of fibrovascular stroma of the esophagus" [MPATH:445]
synonym: "esophageal papilloma" RELATED []
synonym: "increased oesophageal papilloma incidence" EXACT []
synonym: "oesophageal papilloma" RELATED []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0002014 ! increased papilloma incidence
is_a: MP:0010292 ! increased alimentary system tumor incidence

[Term]
id: MP:0003278
name: esophageal inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [NCBI:matt]
synonym: "esophagitis" EXACT []
synonym: "inflammation of esophagus" EXACT []
synonym: "inflammation of oesophagus" EXACT []
synonym: "oesophageal inflammation" EXACT []
synonym: "oesophagitis" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0003279
name: aneurysm
def: "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [ISBN:0-683-40008-8, MESH:C14.907.055, NCBI:matt]
subset: CvDC_Terms
xref: Fyler:2399
is_a: MP:0002127 ! abnormal cardiovascular system morphology

[Term]
id: MP:0003280
name: urinary incontinence
def: "inability to control the urinary bladder excretory functions leading to involuntary urination" [NCBI:matt]
is_a: MP:0001756 ! abnormal urination

[Term]
id: MP:0003281
name: fecal incontinence
def: "inability to control the anal sphincter resulting in the involuntary passage of feces" [MESH:C06.405.469.860.300, NCBI:matt]
synonym: "faecal incontinence" EXACT []
is_a: MP:0003866 ! abnormal defecation

[Term]
id: MP:0003282
name: gastric ulcer
def: "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MESH:C06.405.608.849, NCBI:matt]
is_a: MP:0003301 ! peptic ulcer
is_a: MP:0010792 ! abnormal stomach mucosa morphology

[Term]
id: MP:0003283
name: abnormal digestive organ placement
def: "different location or arrangement of any of the alimentary tract organs" [NCBI:matt]
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003284
name: abnormal large intestine placement
def: "different location or arrangement of the large intestinal tract" [NCBI:matt]
is_a: MP:0000489 ! abnormal large intestine morphology
is_a: MP:0014023 ! abnormal intestine placement

[Term]
id: MP:0003285
name: gastric hypertrophy
def: "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [NCBI:matt]
is_a: MP:0003883 ! enlarged stomach

[Term]
id: MP:0003286
name: gastroesophageal reflux
def: "retrograde movement of gastric contents into the esophagus" [MESH:C06.405.117.119.500.484, NCBI:matt]
is_a: MP:0010154 ! abnormal gastroesophageal sphincter physiology

[Term]
id: MP:0003287
name: increased intestinal hemangioma incidence
def: "greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the intestines, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
synonym: "increased intestinal haemangioma incidence" EXACT []
synonym: "intestinal angioma" RELATED []
synonym: "intestinal haemangioma" RELATED []
synonym: "intestinal hemangioma" RELATED []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0010279 ! increased gastrointestinal tumor incidence

[Term]
id: MP:0003288
name: intestinal edema
def: "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells" [NCBI:matt]
synonym: "intestinal oedema" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0001785 ! edema

[Term]
id: MP:0003289
name: abnormal intestinal peristalsis
def: "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0005620 ! abnormal muscle contractility
is_a: MP:0011082 ! abnormal gastrointestinal motility

[Term]
id: MP:0003290
name: intestinal hypoperistalsis
def: "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "hypanakinesia" EXACT []
synonym: "hypoperistalsis" BROAD []
is_a: MP:0003289 ! abnormal intestinal peristalsis

[Term]
id: MP:0003291
name: interstinal hyperperistalsis
def: "increased intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "hyperanakinesia" EXACT []
synonym: "hyperperistalsis" BROAD []
is_a: MP:0003289 ! abnormal intestinal peristalsis

[Term]
id: MP:0003292
name: melena
def: "dark colored, foul-smelling feces due to the presence of blood" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "blood in faeces" EXACT []
synonym: "blood in feces" EXACT []
synonym: "bloody stool" EXACT []
synonym: "melanorhhagia" EXACT []
synonym: "melanorrhea" EXACT []
is_a: MP:0003868 ! abnormal feces composition

[Term]
id: MP:0003293
name: rectal hemorrhage
def: "bleeding in the rectum" [NCBI:matt]
synonym: "rectal bleeding" EXACT []
synonym: "rectal haemorrhage" EXACT []
is_a: MP:0031156 ! large intestine hemorrhage

[Term]
id: MP:0003294
name: intussusception
def: "telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction" [MESH:C06.405.469.531.577, NCBI:matt]
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0003295
name: lymphomesenteric cyst
def: "cystic mass in the abdominal mesenchyme containing lymph; sometimes becomes calcified" [NCBI:matt]
synonym: "lymphomesenteric cysts" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003296
name: microcolon
def: "small, unused colon in neonates, usually due to atresia or other gastrointestinal blockage" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0000495 ! abnormal colon morphology

[Term]
id: MP:0003298
name: choking
def: "spasm of the larynx and trachea due to prevention of respiration by compression or obstruction" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0003299
name: gastric polyps
def: "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the stomach" [MESH:C23.300.825, NCBI:matt]
synonym: "gastric polyposis" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0010352 ! gastrointestinal tract polyps

[Term]
id: MP:0003300
name: gastrointestinal ulcer
def: "any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue" [NCBI:matt]
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003301
name: peptic ulcer
def: "any lesion on the mucosal surface of the portion of the alimentary tract that is exposed to gastric acid, usually in the stomach or the duodenum" [ISBN:0-683-40008-8, MESH:C06.405.469.275.800, NCBI:matt]
synonym: "gastroduodenal ulcer" EXACT []
synonym: "marginal ulcer" EXACT []
is_a: MP:0003300 ! gastrointestinal ulcer

[Term]
id: MP:0003302
name: perirectal abscess
def: "acute focal inflammation of the tissues surrounding the rectum, often with accumulation of purulent material" [NCBI:matt]
is_a: MP:0000492 ! abnormal rectum morphology

[Term]
id: MP:0003303
name: peritoneal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "peritoneum inflammation" EXACT []
synonym: "peritonitis" RELATED []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0003304
name: large intestinal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [NCBI:matt]
is_a: MP:0001858 ! intestinal inflammation

[Term]
id: MP:0003305
name: proctitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MESH:C06.405.205.865, NCBI:matt]
synonym: "rectitis" EXACT []
is_a: MP:0003304 ! large intestinal inflammation

[Term]
id: MP:0003306
name: small intestinal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [NCBI:matt]
is_a: MP:0001858 ! intestinal inflammation

[Term]
id: MP:0003307
name: pyloric stenosis
def: "abnormal narrowing or constriction of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, NCBI:matt]
subset: CvDC_Terms
xref: Fyler:4444
is_a: MP:0010785 ! abnormal stomach pyloric region morphology

[Term]
id: MP:0003308
name: abnormal cochlear sensory epithelium morphology
def: "any structural anomaly of the epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cochlear neuroepithelium" EXACT []
synonym: "abnormal inner ear neuroepithelium" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003309
name: abnormal cochlear modiolus morphology
def: "any structural anomaly of the central cone shaped core of spongy bone about which turns the spiral canal" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0003310
name: reduced cochlear modiolus
def: "a reduction in the volume of the central conical bony pillar of the cochlea" [https://orcid.org/0000-0002-6490-7723, J:66787]
is_a: MP:0003309 ! abnormal cochlear modiolus morphology

[Term]
id: MP:0003311
name: aminoaciduria
def: "excretion of amino acids in the urine, especially in excessive amounts" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperaminoaciduria" EXACT []
is_a: MP:0010028 ! aciduria
is_a: MP:0011468 ! abnormal urine amino acid level

[Term]
id: MP:0003312
name: abnormal locomotor coordination
def: "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in behavioral locomotor activity" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001392 ! abnormal locomotor behavior

[Term]
id: MP:0003313
name: abnormal locomotor activation
def: "altered ability or desire of an animal to initiate locomotor activity" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001392 ! abnormal locomotor behavior

[Term]
id: MP:0003314
name: dysmetria
def: "an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0003315
name: abnormal perineum morphology
def: "any structural anomaly of the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "perineum dysplasia" RELATED []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0003316
name: perineal fistula
def: "an abnormal anatomical passage that connects the perineum to organs such as the bladder or the rectum" [MESH:C23.300.575, NCBI:matt]
is_a: MP:0003315 ! abnormal perineum morphology

[Term]
id: MP:0003317
name: anoperineal fistula
def: "an abnormal anatomical passage that connects the perineum to the anal canal" [NCBI:matt]
synonym: "ano-perineal fistula" EXACT []
is_a: MP:0003316 ! perineal fistula
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0003318
name: rectoperineal fistula
def: "an abnormal anatomical passage that connects the perineum to the rectum" [MESH:C23.300.575, NCBI:matt]
synonym: "recto-perineal fistula" EXACT []
synonym: "recto-peritoneal fistula" EXACT []
synonym: "rectoperitoneal fistula" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
is_a: MP:0003316 ! perineal fistula

[Term]
id: MP:0003319
name: anal fistula
def: "an abnormal anatomical passage at or near the anus that usually opens into the rectum above the internal sphincter" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0003320
name: rectovaginal fistula
def: "an abnormal anatomical passage connecting the rectum and the vagina" [MESH:C06.267.550.600.650, NCBI:matt]
synonym: "recto-vaginal fistula" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003321
name: tracheoesophageal fistula
alt_id: MP:0003117
def: "an abnormal passage is present between the esophagus and the trachea; may be acquired or congenital, and is often associated with esophageal atresia" [MESH:C06.267.250.725, NCBI:matt]
subset: CvDC_Terms
synonym: "esophago-tracheal fistula" EXACT []
synonym: "esophagotracheal fistula" EXACT []
synonym: "impaired tracheal-esophageal septation" EXACT []
synonym: "impaired tracheal-oesophageal septation" EXACT []
synonym: "oesophago-tracheal fistula" EXACT []
synonym: "oesophagotracheal fistula" EXACT []
synonym: "tracheo-oesophageal fistula" EXACT []
xref: Fyler:4202
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0003322
name: biliary fistula
def: "an abnormal anatomical passage that connects any organ of the biliary tract and other organs" [MESH:C06.267.150, NCBI:matt]
is_a: MP:0005083 ! abnormal biliary tract morphology

[Term]
id: MP:0003323
name: gastrocolic fistula
def: "an abnormal anatomical passage between the stomach and the colon" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0000495 ! abnormal colon morphology

[Term]
id: MP:0003324
name: increased liver adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the liver, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "increased hepatocellular adenoma incidence" EXACT []
is_a: MP:0008019 ! increased liver tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0003325
name: decreased liver function
def: "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage" [NCBI:matt]
synonym: "reduced hepatic function" EXACT []
synonym: "reduced liver function" EXACT []
is_a: MP:0000609 ! abnormal liver physiology

[Term]
id: MP:0003326
name: liver failure
def: "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [NCBI:matt]
synonym: "hepatic failure" EXACT []
is_a: MP:0000609 ! abnormal liver physiology

[Term]
id: MP:0003327
name: liver cyst
def: "presence of one or more abnormal membranous sacs in any portion of the liver" [NCBI:matt]
synonym: "hepatic cyst" EXACT []
synonym: "hepatic cysts" EXACT []
synonym: "liver cysts" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003328
name: portal hypertension
def: "elevation of blood pressure in the hepatic portal vein, often a result of cirrhosis or from obstruction of the portal vein" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0000609 ! abnormal liver physiology
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0003329
name: amyloid beta deposits
def: "formation of self-assembled aggregates of the cleaved App Abeta protein fragment; often seen in neurodegenerative disorders such as Alzheimer's disease" [https://orcid.org/0000-0003-3691-0324]
synonym: "amyloid beta plaques" EXACT []
synonym: "increased amyloid beta deposition" EXACT []
is_a: MP:0000604 ! amyloidosis
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0003330
name: abnormal auditory tube morphology
def: "any structural anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [ISBN:0-683-40008-8]
synonym: "abnormal Eustachian tube" EXACT []
synonym: "abnormal pharyngotympanic tube" EXACT []
is_a: MP:0000049 ! abnormal middle ear morphology

[Term]
id: MP:0003331
name: increased hepatocellular carcinoma incidence
alt_id: MP:0005510
def: "greater than the expected number of a malignant neoplasm arising from liver cells, usually in adults and caused by liver trauma due to disease or injury, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "HCC" RELATED []
synonym: "hepatocellular carcinoma" RELATED []
synonym: "liver neoplasia" BROAD []
synonym: "liver neoplasm" BROAD []
synonym: "malignant hepatoma" RELATED []
synonym: "neoplastic liver" BROAD []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0008019 ! increased liver tumor incidence

[Term]
id: MP:0003332
name: liver abscess
def: "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents" [NCBI:matt]
synonym: "hepatic abscess" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0003333
name: liver fibrosis
def: "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury" [MESH:C23.550.355, NCBI:matt]
synonym: "hepatic fibrosis" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0003334
name: pancreas fibrosis
def: "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury" [MESH:C23.550.355, NCBI:matt]
synonym: "pancreatic fibrosis" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0003335
name: exocrine pancreatic insufficiency
def: "inadequate synthesis and/or secretion of digestive enzymes by the exocrine portion of the pancreas, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causing maldigestion and malabsorption of nutrients" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0010148 ! abnormal exocrine pancreas physiology

[Term]
id: MP:0003336
name: pancreas cyst
def: "presence of one or more abnormal fluid-filled sacs within the pancreas" [NCBI:matt]
synonym: "cystic pancreas" EXACT []
synonym: "pancreas cysts" EXACT []
synonym: "pancreatic cyst" EXACT []
synonym: "pancreatic cysts" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003337
name: exocrine pancreas hyperplasia
def: "increase in the number of normal cells in normal arrangement in the exocrine pancreas, typically resulting in increased size" [MESH:A03.734.540, NCBI:matt]
synonym: "exocrine pancreatic hyperplasia" EXACT []
synonym: "hyperplastic exocrine pancreas" EXACT []
synonym: "increased exocrine pancreas cellularity" RELATED []
is_a: MP:0005220 ! abnormal exocrine pancreas morphology
is_a: MP:0009110 ! pancreas hyperplasia

[Term]
id: MP:0003338
name: pancreas lipomatosis
def: "an accumulation of abnormally localized or tumor-like fat in the pancreas" [MESH:C17.800.463, NCBI:matt]
synonym: "pancreatic lipomatosis" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0003339
name: decreased pancreatic beta cell number
def: "fewer than normal number of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131, NCBI:matt]
synonym: "decreased number of pancreatic beta cells" EXACT []
synonym: "reduced pancreatic beta cell number" EXACT []
is_a: MP:0020578 ! abnormal pancreatic beta cell number

[Term]
id: MP:0003340
name: acute pancreas inflammation
def: "early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the pancreas; initiated by injury, infection, or local immune response" [NCBI:matt]
is_a: MP:0001869 ! pancreas inflammation
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0003341
name: chronic pancreas inflammation
def: "persistent inflammatory response in the pancreas, often caused by persistent infection or during an autoimmune response" [NCBI:matt]
is_a: MP:0001869 ! pancreas inflammation
is_a: MP:0002499 ! chronic inflammation

[Term]
id: MP:0003342
name: accessory spleen
def: "the splenic tissue is divided into equal masses; often related to situs inversus" [ISBN:0-683-40008-8, NCBI:matt]
subset: CvDC_Terms
synonym: "polysplenia" RELATED []
xref: Fyler:4772
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0003344
name: mammary gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mammary gland, typically resulting in decreased size" [NCBI:matt]
synonym: "breast hypoplasia" EXACT []
synonym: "Brustdruese hypoplasia" EXACT []
synonym: "glandula mammaria hypoplasia" EXACT []
synonym: "Lactiferous gland hypoplasia" EXACT []
synonym: "lactiferous gland hypoplasia" EXACT []
synonym: "Lobe of breast hypoplasia" EXACT []
synonym: "lobe of breast hypoplasia" EXACT []
synonym: "Lobe of mammary gland hypoplasia" EXACT []
synonym: "lobe of mammary gland hypoplasia" EXACT []
synonym: "mamma hypoplasia" EXACT []
synonym: "mammae hypoplasia" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0003345
name: decreased rib number
def: "fewer than normal numbers of the pairs of bony structures that make up the body wall" [ISBN:0-683-40008-8, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of ribs" EXACT []
synonym: "reduced rib number" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0003346
name: abnormal pectoral muscle morphology
def: "any structural anomaly of the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs" [ISBN:0-683-40008-8, MESH:A02.633.567.775, NCBI:matt]
synonym: "abnormal pectoralis muscle morphology" EXACT [MESH:A02.633.567.775]
is_a: MP:0003358 ! abnormal hypaxial muscle morphology

[Term]
id: MP:0003347
name: hyperpituitarism
def: "hypersecretion of adenohypophyseal hormones from the glandular, anterior portion of the pituitary; often due to a functional adenoma" [MESH:C10.228.140.617.738.250, NCBI:matt]
synonym: "increased pituitary hormone secretion" EXACT []
is_a: MP:0001746 ! abnormal pituitary secretion

[Term]
id: MP:0003348
name: hypopituitarism
def: "reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma" [MESH:C10.228.140.617.738.300, NCBI:matt]
synonym: "pituitary insufficiency" EXACT []
synonym: "reduced pituitary hormone secretion" EXACT []
is_a: MP:0001746 ! abnormal pituitary secretion

[Term]
id: MP:0003349
name: abnormal circulating renin level
def: "aberrant blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I" [MESH:D08.811.277.656.300.066.780, NCBI:matt]
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0003350
name: increased circulating levels of thyroid hormone
def: "increased concentration of hormones in the blood that are synthesized and secreted by the thyroid" [NCBI:matt]
is_a: MP:0005468 ! abnormal thyroid hormone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003351
name: decreased circulating levels of thyroid hormone
def: "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [NCBI:matt]
synonym: "reduced circulating levels of thyroid hormone" EXACT []
is_a: MP:0005468 ! abnormal thyroid hormone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003352
name: increased circulating renin level
def: "elevated blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I" [MESH:D08.811.277.656.300.066.780, NCBI:matt]
is_a: MP:0003349 ! abnormal circulating renin level
is_a: MP:0014450 ! increased circulating enzyme level

[Term]
id: MP:0003353
name: decreased circulating renin level
def: "reduced blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I" [MESH:D08.811.277.656.300.066.780, NCBI:matt]
synonym: "reduced circulating renin level" EXACT []
is_a: MP:0003349 ! abnormal circulating renin level
is_a: MP:0014451 ! decreased circulating enzyme level

[Term]
id: MP:0003354
name: astrocytosis
def: "a proliferation or spread of astrocytes into the area of a degenerative lesion or damaged tissue" [MESH:C23.550.369]
synonym: "astrogliosis" EXACT []
synonym: "reactive astrogliosis" EXACT []
is_a: MP:0002183 ! gliosis
is_a: MP:0012065 ! increased astrocyte number

[Term]
id: MP:0003355
name: decreased ovulation rate
def: "reduction in the frequency in which an ovum (or ova) is/are released from a rupturing ovarian follicle(s)" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased ovulation frequency" EXACT []
synonym: "reduced ovulation" BROAD []
is_a: MP:0001928 ! abnormal ovulation

[Term]
id: MP:0003356
name: impaired luteinization
def: "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [https://orcid.org/0000-0002-6490-7723, J:43075, J:57854]
synonym: "impaired luteal phase" RELATED []
synonym: "impaired luteinisation" EXACT []
is_a: MP:0009344 ! abnormal ovulation cycle

[Term]
id: MP:0003357
name: impaired granulosa cell differentiation
def: "atypical production of or inability to produce the supporting cells for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
is_a: MP:0003507 ! abnormal ovary physiology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0003358
name: abnormal hypaxial muscle morphology
def: "any structural anomaly of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [PMID:1591996]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0003359
name: hypaxial muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the hypaxial muscle, typically resulting in decreased size" [PMID:1591996]
synonym: "hypoplastic hypaxial muscle" EXACT []
is_a: MP:0000734 ! muscle hypoplasia
is_a: MP:0003358 ! abnormal hypaxial muscle morphology

[Term]
id: MP:0003360
name: abnormal depression-related behavior
def: "responses to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:cur]
synonym: "abnormal depression-related behaviour" EXACT []
is_a: MP:0002572 ! abnormal emotion/affect behavior

[Term]
id: MP:0003361
name: abnormal circulating gonadotropin level
def: "aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis" [MESH:D06.472.699.322]
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0003362
name: increased circulating gonadotropin level
def: "greater than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis" [MESH:D06.472.699.322, NCBI:matt]
is_a: MP:0003361 ! abnormal circulating gonadotropin level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003363
name: decreased circulating gonadotropin level
def: "less than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis" [MESH:D06.472.699.322, NCBI:matt]
synonym: "reduced circulating gonadotropin level" EXACT []
is_a: MP:0003361 ! abnormal circulating gonadotropin level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003364
name: increased insulinoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet beta cells, occurring in a specific population in a given time period; these tumors secrete excess insulin" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "increased beta-cell adenoma incidence" EXACT []
synonym: "increased beta-cell tumor incidence" EXACT []
synonym: "increased insuloma incidence" EXACT []
synonym: "increased pancreatic beta cell tumor incidence" EXACT []
is_a: MP:0003430 ! increased pancreatic islet cell adenoma incidence

[Term]
id: MP:0003365
name: increased glucagonoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet alpha cells, occurring in a specific population in a given time period; these tumors secrete excess glucagon" [https://orcid.org/0000-0003-3691-0324, MESH:C04.557.470.200.025.290.750, NCBI:matt]
synonym: "increased alpha-cell adenoma incidence" EXACT []
synonym: "increased alpha-cell tumor incidence" EXACT []
is_a: MP:0003430 ! increased pancreatic islet cell adenoma incidence

[Term]
id: MP:0003366
name: abnormal circulating glucocorticoid level
def: "aberrant blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0003367
name: increased circulating glucocorticoid level
def: "greater than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [NCBI:matt]
is_a: MP:0003366 ! abnormal circulating glucocorticoid level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003368
name: decreased circulating glucocorticoid level
def: "less than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [NCBI:matt]
synonym: "reduced circulating glucocorticoid level" RELATED []
is_a: MP:0003366 ! abnormal circulating glucocorticoid level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003369
name: abnormal circulating estrogen level
def: "aberration in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0003370
name: increased circulating estrogen level
def: "greater than normal blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [NCBI:matt]
synonym: "increased circulating oestrogen level" EXACT []
is_a: MP:0003369 ! abnormal circulating estrogen level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003371
name: decreased circulating estrogen level
def: "reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [NCBI:matt]
synonym: "decreased circulating oestrogen level" EXACT []
synonym: "reduced circulating estrogen level" EXACT []
synonym: "reduced circulating oestrogen level" EXACT []
is_a: MP:0003369 ! abnormal circulating estrogen level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003372
name: abnormal circulating mineralocorticoid level
def: "aberrant blood concentration of corticosteroids that influence water and electrolyte metabolism and balance" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0003373
name: increased circulating mineralocorticoid level
def: "greater than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003372 ! abnormal circulating mineralocorticoid level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003374
name: decreased circulating mineralocorticoid level
def: "less than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "reduced circulating mineralocorticoid level" EXACT []
is_a: MP:0003372 ! abnormal circulating mineralocorticoid level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003375
name: abnormal menstrual cycle
def: "failure of or aberrant timing of a recurring cycle in human primates in which the endometrial lining of the uterus prepares for pregnancy and ovulation occurs; if pregnancy does not occur the lining is discharged at menstruation" [NCBI:matt]
is_a: MP:0009344 ! abnormal ovulation cycle

[Term]
id: MP:0003376
name: amenorrhea
def: "absence or abnormal cessation of the shedding of the endometrium and associated bleeding in primates" [MESH:C23.550.568.500, NCBI:matt]
synonym: "absent menstruation" EXACT []
is_a: MP:0003375 ! abnormal menstrual cycle

[Term]
id: MP:0003377
name: late onset of menarche
def: "the onset of menstrual cycles occurs at a later age than normal" [NCBI:matt]
is_a: MP:0001938 ! delayed sexual maturation

[Term]
id: MP:0003378
name: early sexual maturation
def: "pubertal changes occur at an earlier than normal age" [NCBI:matt]
synonym: "early onset of sexual maturity" EXACT []
synonym: "precocious puberty" EXACT []
is_a: MP:0001937 ! abnormal sexual maturation

[Term]
id: MP:0003379
name: absent sexual maturation
def: "failure to initiate pubertal changes that result in achievement of full sexual capacity" [NCBI:matt]
is_a: MP:0001937 ! abnormal sexual maturation

[Term]
id: MP:0003380
name: abnormal intestine regeneration
def: "anomaly in the renewal, repair, and/or regrowth of intestinal tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intestinal regeneration" EXACT []
is_a: MP:0010155 ! abnormal intestine physiology

[Term]
id: MP:0003381
name: vitreal fibroplasia
def: "production of excess fibrous tissue in the vitreous body of the eye" [MGI:brs]
synonym: "corpus vitreum fibroplasia" EXACT []
synonym: "hyaloid body fibroplasia" EXACT []
synonym: "vitreal body fibroplasia" EXACT []
synonym: "vitreous body fibroplasia" EXACT []
synonym: "vitreum fibroplasia" EXACT []
is_a: MP:0002699 ! abnormal vitreous body morphology

[Term]
id: MP:0003382
name: straub tail
def: "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001391 ! abnormal tail movements

[Term]
id: MP:0003383
name: abnormal gluconeogenesis
def: "anomaly in the formation of glucose from non-carbohydrates, such as proteins or fat" [J:93896]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0003384
name: abnormal ventral body wall morphology
def: "any structural anomaly of the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0009-0005-7755-8314]
synonym: "ventral body wall defects" EXACT []
is_a: MP:0003385 ! abnormal body wall morphology

[Term]
id: MP:0003385
name: abnormal body wall morphology
def: "any structural anomaly of the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0003386
name: obsolete increased sensitivity to nicotine
def: "OBSOLETE. decreased threshold to obtain a physiological or behavioral response to nicotine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to nicotine" EXACT []
synonym: "increased susceptibility to nicotine" EXACT []
synonym: "nicotine hypersensitivity" EXACT []
is_obsolete: true

[Term]
id: MP:0003387
name: aorta coarctation
def: "a congenital focal constriction of the aorta most commonly found just distal to the origin of the left subclavian artery; the most commonly found form is juxtaductal coarctation, but it may occur at any point from the transverse arch to the iliac bifurcation" [http://emedicine.medscape.com, NCBI:matt]
subset: CvDC_Terms
synonym: "aortic coarctation" EXACT []
synonym: "coarctation of aorta" EXACT []
is_a: MP:0000272 ! abnormal aorta morphology

[Term]
id: MP:0003388
name: absent pericardium
def: "absence of the fibroserous membrane covering the heart and beginning of the great vessels" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "absent pericardial sac" EXACT []
synonym: "pericardial agenesis" EXACT []
xref: Fyler:1910
is_a: MP:0000288 ! abnormal pericardium morphology

[Term]
id: MP:0003389
name: constriction of pericardium
def: "tightening of the pericardium around the heart" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0000288 ! abnormal pericardium morphology

[Term]
id: MP:0003390
name: lymphedema
def: "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001785 ! edema

[Term]
id: MP:0003391
name: increased myxoma incidence
def: "higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; may show multiple differentiated components" [MPATH:431]
synonym: "myxoma" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0003392
name: increased atrial myxoma incidence
def: "higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of either the left or right atrium connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; an increase in primary intracardiac tumor incidence" [MPATH:431]
synonym: "atrial myxoma" RELATED []
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0003391 ! increased myxoma incidence
is_a: MP:0010291 ! increased cardiovascular system tumor incidence

[Term]
id: MP:0003393
name: decreased cardiac output
def: "reduction in the blood volume pumped by each ventricle per minute" [https://orcid.org/0000-0003-4606-0597, MESH:E01.370.370.380.150, NCBI:matt]
synonym: "reduced cardiac output" EXACT []
is_a: MP:0001627 ! abnormal cardiac output

[Term]
id: MP:0003394
name: increased cardiac output
def: "greater than normal blood volume pumped by each ventricle per minute" [https://orcid.org/0000-0003-4606-0597, MESH:E01.370.370.380.150, NCBI:matt]
is_a: MP:0001627 ! abnormal cardiac output

[Term]
id: MP:0003395
name: abnormal subclavian artery morphology
def: "any structural anomaly of the right or left subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body and the left subclavian artery extends from the aortic arch to the left side of the body" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0003396
name: abnormal embryonic hematopoiesis
def: "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages that circulate in the embryonic and extraembryonic tissues, and which occurs in blood islands in the yolk sac from E7-E11 in the mouse and through 10 weeks in humans" [https://orcid.org/0000-0003-4606-0597, J:94136]
synonym: "abnormal embryonic haematopoiesis" EXACT []
synonym: "abnormal primitive haematopoiesis" EXACT []
synonym: "abnormal primitive hematopoiesis" EXACT []
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
is_a: MP:0013693 ! abnormal hemopoiesis

[Term]
id: MP:0003397
name: increased muscle weight
def: "greater than average muscle weight" [https://orcid.org/0000-0003-4606-0597, J:94134]
is_a: MP:0004233 ! abnormal muscle weight

[Term]
id: MP:0003398
name: increased skeletal muscle size
def: "greater than average dimensions of one or more of the muscles of the skeleton" [https://orcid.org/0000-0003-4606-0597, J:94134]
is_a: MP:0004818 ! increased skeletal muscle mass
is_a: MP:0009458 ! abnormal skeletal muscle size

[Term]
id: MP:0003400
name: kinked neural tube
def: "twists or kinks in the embryonic neural tube" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0003401
name: enlarged tail bud
def: "increased size or area of the primordial region of the embryo that arises to form the tail of the adult" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased tail bud size" EXACT []
is_a: MP:0002861 ! abnormal tail bud morphology

[Term]
id: MP:0003402
name: decreased liver weight
def: "reduced average weight of the bile-secreting exocrine gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hepatic weight" EXACT []
synonym: "reduced hepatic weight" EXACT []
synonym: "reduced liver weight" EXACT []
is_a: MP:0000601 ! small liver
is_a: MP:0004847 ! abnormal liver weight

[Term]
id: MP:0003403
name: absent placental labyrinth
def: "absence of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001716 ! abnormal placenta labyrinth morphology

[Term]
id: MP:0003404
name: absent enamel
def: "absence of the hard outer coating of the exposed portion of the tooth" [ISBN:0-683-40008-8]
is_a: MP:0002576 ! abnormal enamel morphology

[Term]
id: MP:0003405
name: abnormal platelet shape
def: "any anomaly in the characteristic surface outline or contour of the normal small, disk-like shape of blood plasma cells derived from megakaryocytes and which function to promote blood clotting" [MESH:A11.118.188]
synonym: "abnormal thrombocyte shape" EXACT []
is_a: MP:0004720 ! abnormal platelet morphology

[Term]
id: MP:0003406
name: failure of zygotic cell division
def: "inability of a fertilized oocyte to initiate or complete early cell divisions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001730 ! embryonic growth arrest
is_a: MP:0009781 ! abnormal preimplantation embryo development

[Term]
id: MP:0003407
name: abnormal central nervous system regeneration
def: "anomaly in the renewal, repair, and/or regrowth of central nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal CNS regeneration" EXACT []
is_a: MP:0004858 ! abnormal nervous system regeneration

[Term]
id: MP:0003408
name: increased width of hypertrophic chondrocyte zone
def: "increased width of cartilage cell matrix layer" [ISBN:0-683-40008-8]
is_a: MP:0000165 ! abnormal long bone hypertrophic chondrocyte zone

[Term]
id: MP:0003409
name: decreased width of hypertrophic chondrocyte zone
def: "decreased width of cartilage cell matrix layer" [ISBN:0-683-40008-8]
synonym: "reduced width of hypertrophic chondrocyte zone" EXACT []
is_a: MP:0000165 ! abnormal long bone hypertrophic chondrocyte zone

[Term]
id: MP:0003410
name: abnormal artery development
def: "anomaly in the process of forming the blood vessels that carry blood away from the heart" [https://orcid.org/0000-0003-4606-0597, MESH:A07.231.114]
is_a: MP:0000260 ! abnormal angiogenesis
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0003411
name: abnormal vein development
def: "anomaly in the process of forming the blood vessels that carry blood to the heart" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000260 ! abnormal angiogenesis
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0003412
name: abnormal afterhyperpolarization
def: "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [https://orcid.org/0000-0003-4606-0597, PMID:15190101]
synonym: "abnormal AHP" EXACT []
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0003413
name: hair follicle degeneration
def: "a retrogressive impairment of function or destruction of the hair follicle" [https://orcid.org/0009-0005-7755-8314]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000377 ! abnormal hair follicle morphology

[Term]
id: MP:0003414
name: epidermal cyst
def: "presence of one or more benign masses derived from the epidermis or the epithelium of a hair follicle, formed by enclosure of epithelium within the dermis and filled with keratin and lipid-rich inclusions" [https://orcid.org/0009-0005-7755-8314, ISBN:0-683-40008-8, MESH:C04.182.254, MGI:llw2]
synonym: "cystic epidermis" EXACT []
synonym: "epidermal cysts" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology
is_a: MP:0031309 ! skin cyst

[Term]
id: MP:0003415
name: priapism
def: "prolonged penile erection, often painful and without sexual desire" [https://orcid.org/0000-0003-4606-0597, MESH:C12.294.494.786]
is_a: MP:0001379 ! abnormal penile erection

[Term]
id: MP:0003416
name: premature bone ossification
def: "early onset of the formation of bone" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0003417
name: premature endochondral bone ossification
def: "early onset of bone formation in bones that form from cartilage" [https://orcid.org/0000-0003-4606-0597, J:94631]
is_a: MP:0003416 ! premature bone ossification
is_a: MP:0008272 ! abnormal endochondral bone ossification

[Term]
id: MP:0003418
name: premature intramembranous bone ossification
def: "early onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003416 ! premature bone ossification
is_a: MP:0008273 ! abnormal intramembranous bone ossification

[Term]
id: MP:0003419
name: delayed endochondral bone ossification
def: "late onset of bone formation in bones that form from cartilage" [https://orcid.org/0000-0003-4606-0597, J:94631]
is_a: MP:0000060 ! delayed bone ossification
is_a: MP:0008272 ! abnormal endochondral bone ossification

[Term]
id: MP:0003420
name: delayed intramembranous bone ossification
def: "late onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle" [https://orcid.org/0000-0003-4606-0597, J:94631]
is_a: MP:0000060 ! delayed bone ossification
is_a: MP:0008273 ! abnormal intramembranous bone ossification

[Term]
id: MP:0003421
name: abnormal thyroid gland development
def: "failure or abnormality in the formation of the thyroid gland during organogenesis" [https://orcid.org/0000-0003-4606-0597, J:95017]
synonym: "abnormal thyroid development" RELATED []
is_a: MP:0000681 ! abnormal thyroid gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0003422
name: abnormal thrombolysis
def: "altered ability to break up (lyse) blood clots that are restricting the blood flow" [https://orcid.org/0000-0002-6490-7723, J:17427]
is_a: MP:0002551 ! abnormal blood coagulation

[Term]
id: MP:0003423
name: reduced thrombolysis
def: "reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow" [https://orcid.org/0000-0002-6490-7723, J:17427]
is_a: MP:0003422 ! abnormal thrombolysis

[Term]
id: MP:0003424
name: premature neuronal precursor differentiation
def: "earlier than normal transformation of neuronal precursor cells into neurons" [https://orcid.org/0000-0003-4606-0597, J:94391]
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0003425
name: abnormal optic vesicle formation
def: "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [https://orcid.org/0000-0003-4606-0597, J:94391]
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0003426
name: pulmonary interstitial fibrosis
def: "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002276 ! abnormal lung interstitium morphology
is_a: MP:0006050 ! pulmonary fibrosis

[Term]
id: MP:0003427
name: parakeratosis
def: "thickening of the stratum corneum of the epidermis (hyperkeratosis) with nucleated keratinocytes retained in this layer" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "parakeratotic hyperkeratosis" EXACT []
is_a: MP:0001242 ! hyperkeratosis

[Term]
id: MP:0003429
name: insensitivity to growth hormone
def: "no growth response to exogenous growth hormone" [NCBI:matt]
is_a: MP:0003638 ! abnormal response/metabolism to endogenous compounds

[Term]
id: MP:0003430
name: increased pancreatic islet cell adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the islet cells of the pancreas, occurring in a specific population in a given time period" [NCBI:matt]
is_a: MP:0009043 ! increased pancreas adenoma incidence

[Term]
id: MP:0003431
name: abnormal parathyroid gland physiology
def: "any functional anomaly of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [NCBI:matt]
is_a: MP:0013561 ! abnormal endocrine gland physiology

[Term]
id: MP:0003432
name: increased activity of parathyroid
def: "increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [NCBI:matt]
synonym: "hyperparathyroidism" EXACT []
is_a: MP:0003431 ! abnormal parathyroid gland physiology

[Term]
id: MP:0003433
name: decreased activity of parathyroid
def: "reduced function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [NCBI:matt]
synonym: "hypoparathyroidism" EXACT []
synonym: "reduced activity of parathyroid" EXACT []
is_a: MP:0003431 ! abnormal parathyroid gland physiology

[Term]
id: MP:0003434
name: decreased susceptibility to induced choroidal neovascularization
def: "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to induced choroidal neovascularization" EXACT []
is_a: MP:0005546 ! choroidal neovascularization

[Term]
id: MP:0003435
name: herniated seminal vesicle
def: "protrusion of the seminal vesicles through the pelvic outlet" [https://orcid.org/0000-0002-6490-7723, J:73613]
synonym: "herniated seminal glands" EXACT []
synonym: "herniated seminal vesicles" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0003436
name: decreased susceptibility to induced arthritis
def: "less likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to induced arthritis" EXACT []
is_a: MP:0002993 ! autoimmune arthritis
is_a: MP:0003079 ! decreased susceptibility to induced joint inflammation
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0003437
name: abnormal carotid body morphology
def: "any structural anomaly of a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [https://orcid.org/0009-0005-7755-8314, ISBN:0-683-40008-8, MESH:A08.800.550.700.120.600.150]
is_a: MP:0004181 ! abnormal carotid artery morphology

[Term]
id: MP:0003438
name: abnormal carotid body physiology
def: "any functional anomaly in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [https://orcid.org/0009-0005-7755-8314, ISBN:0-683-40008-8, MESH:A08.800.550.700.120.600.150]
is_a: MP:0000249 ! abnormal blood vessel physiology

[Term]
id: MP:0003439
name: abnormal glycerol level
def: "abnormal level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0003440
name: decreased glycerol level
def: "reduced level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced glycerol level" EXACT []
is_a: MP:0003439 ! abnormal glycerol level
is_a: MP:0014461 ! decreased lipid level

[Term]
id: MP:0003441
name: increased glycerol level
def: "elevated level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003439 ! abnormal glycerol level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0003442
name: decreased circulating glycerol level
def: "reduced blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced circulating glycerol level" EXACT []
is_a: MP:0003440 ! decreased glycerol level
is_a: MP:0011973 ! abnormal circulating glycerol level

[Term]
id: MP:0003443
name: increased circulating glycerol level
def: "elevated blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "hyperglycerolaemia" EXACT []
synonym: "hyperglycerolemia" EXACT [HP:0040302]
is_a: MP:0003441 ! increased glycerol level
is_a: MP:0011973 ! abnormal circulating glycerol level

[Term]
id: MP:0003444
name: abnormal neurotransmitter uptake
def: "aberration in the reabsorption of endogenous signaling molecules released into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell" [GO:0007269, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0003445
name: sirenomelia
def: "fusion of the caudal-most (posterior or lower) limbs often with partial or complete fusion of the autopods" [ISBN:0-683-40008-8]
synonym: "mermaid malformation" EXACT []
synonym: "symmelia" EXACT []
synonym: "sympus" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0001706 ! abnormal left-right axis patterning
is_a: MP:0006279 ! abnormal limb development

[Term]
id: MP:0003446
name: renal hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the kidney, typically resulting in decreased size" [MGI:llw2]
synonym: "hypoplastic kidney" EXACT []
synonym: "kidney hypoplasia" EXACT []
is_a: MP:0002989 ! small kidney

[Term]
id: MP:0003447
name: decreased tumor growth/size
def: "less than expected development of tumorous growth when compared to controls" [https://orcid.org/0000-0002-6490-7723, J:65383]
synonym: "decreased neoplasm growth/size" BROAD []
synonym: "decreased tumour growth/size" EXACT []
synonym: "reduced tumor growth/size" EXACT []
synonym: "reduced tumour growth/size" EXACT []
is_a: MP:0003448 ! abnormal tumor morphology

[Term]
id: MP:0003448
name: abnormal tumor morphology
def: "any structural anomaly of a given tumor type compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal neoplasm morphology" BROAD []
synonym: "abnormal tumour morphology" EXACT []
synonym: "altered tumor characteristics" EXACT []
synonym: "altered tumor morphology" EXACT []
synonym: "altered tumour characteristics" EXACT []
synonym: "altered tumour morphology" EXACT []
is_a: MP:0010639 ! abnormal tumor pathology

[Term]
id: MP:0003449
name: abnormal intestinal goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; the goblet cell is a highly polarized unicellular exocrine gland with the nucleus and other organelles concentrated at the base of the cell; the remainder of the cell's cytoplasm is occupied by membrane-bound secretory granules containing mucin; the goblet shape is due to the mucus laden granules in the apical part expanding, causing that part of the cell to balloon; the apical plasma membrane projects microvilli to give an increased surface area for secretion" [CL:1000317, http://en.wikipedia.org/wiki/Goblet_cell, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intestinal goblet cells" BROAD []
is_a: MP:0000358 ! abnormal cell morphology
is_a: MP:0000511 ! abnormal intestinal mucosa morphology

[Term]
id: MP:0003450
name: enlarged pancreas
def: "increase of the size of the pancreas compared to controls" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pancreas size" EXACT []
is_a: MP:0009106 ! abnormal pancreas size
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0003451
name: absent olfactory bulb
def: "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [ISBN:0-683-40008-8]
is_a: MP:0000819 ! abnormal olfactory bulb morphology

[Term]
id: MP:0003452
name: abnormal parotid gland morphology
def: "any structural anomaly of either of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal external salivary gland morphology" EXACT []
synonym: "abnormal glandula parotidea morphology" EXACT []
synonym: "abnormal glandula parotis morphology" EXACT []
is_a: MP:0003792 ! abnormal major salivary gland morphology
is_a: MP:0008052 ! abnormal serous gland morphology

[Term]
id: MP:0003453
name: abnormal keratinocyte physiology
def: "abnormal function of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [https://orcid.org/0009-0005-7755-8314, ISBN:0-683-40008-8]
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0003454
name: erythroderma
def: "exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease" [https://orcid.org/0000-0003-4606-0597, J:95549]
is_a: MP:0001194 ! dermatitis

[Term]
id: MP:0003455
name: decreased susceptibility to induced retina damage
def: "reduced or absent pathological changes in the retina due to chemical or mechanical agents" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to induced retinal damage" EXACT []
synonym: "increased resistance to induced retina damage" EXACT []
synonym: "increased resistance to induced retinal damage" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0003456
name: absent tail
alt_id: MP:0005080
def: "completely lacking the appendage at the caudal end of the vertebral column" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "tail less" EXACT []
synonym: "tailless" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0003457
name: abnormal circulating ketone body level
def: "aberrant amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [ISBN:0-683-40008-8]
comment: Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in equilibrium with acetoacetate.
is_a: MP:0002118 ! abnormal lipid homeostasis
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0003458
name: decreased circulating ketone body level
def: "less than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [ISBN:0-683-40008-8]
comment: Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in equilibrium with acetoacetate.
synonym: "hypoketonaemia" EXACT []
synonym: "hypoketonemia" EXACT []
synonym: "hypoketosis" EXACT []
synonym: "hypoketotic" EXACT [PMID:31324765]
synonym: "reduced circulating ketone body level" EXACT []
is_a: MP:0003457 ! abnormal circulating ketone body level

[Term]
id: MP:0003459
name: increased fear-related response
def: "greater emotional response related to anticipation of specific pain or danger" [MGI:CFG]
is_a: MP:0003106 ! abnormal fear-related response

[Term]
id: MP:0003460
name: decreased fear-related response
def: "reduced emotional response related to anticipation of specific pain or danger" [MGI:CFG]
synonym: "reduced fear-related response" EXACT []
is_a: MP:0003106 ! abnormal fear-related response

[Term]
id: MP:0003461
name: abnormal response to novel object
def: "altered behavioral reaction associated with exposing an animal to a novel object" [MGI:CFG]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0003107 ! abnormal response to novelty

[Term]
id: MP:0003462
name: abnormal response to novel odor
def: "altered behavioral reaction associated with exposing an animal to a novel odor" [MGI:CFG]
synonym: "abnormal response to novel odour" EXACT []
is_a: MP:0003107 ! abnormal response to novelty
is_a: MP:0020852 ! abnormal olfactory behavior

[Term]
id: MP:0003463
name: abnormal single cell response
def: "altered values from controls obtained upon extra- or intracellular recordings from single cells" [MGI:Nmice]
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0003464
name: abnormal single cell response threshold
def: "any change in the value at which a stimulus first elicits a recordable response recorded in a single cell" [MGI:Nmice]
is_a: MP:0003463 ! abnormal single cell response

[Term]
id: MP:0003465
name: increased single cell response threshold
def: "increase in the value at which a stimulus first elicits a recordable response recorded in a single cell" [MGI:Nmice]
is_a: MP:0003464 ! abnormal single cell response threshold

[Term]
id: MP:0003466
name: decreased single cell response threshold
def: "reduction in the value at which a stimulus first elicits a recordable response recorded in a single cell" [MGI:Nmice]
synonym: "reduced single cell response threshold" EXACT []
is_a: MP:0003464 ! abnormal single cell response threshold

[Term]
id: MP:0003467
name: abnormal single cell response intensity
def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell" [MGI:Nmice]
is_a: MP:0003463 ! abnormal single cell response

[Term]
id: MP:0003468
name: increased single cell response intensity
def: "increase in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell" [MGI:Nmice]
is_a: MP:0003467 ! abnormal single cell response intensity

[Term]
id: MP:0003469
name: decreased single cell response intensity
def: "reduction in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell" [MGI:Nmice]
synonym: "reduced single cell response intensity" EXACT []
is_a: MP:0003467 ! abnormal single cell response intensity

[Term]
id: MP:0003470
name: abnormal summary potential
def: "anomaly in the electrophysiological recording of the activity of several cells" [MGI:Nmice]
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0003471
name: abnormal summary potential threshold
def: "any change in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice" [MGI:Nmice]
is_a: MP:0003470 ! abnormal summary potential

[Term]
id: MP:0003472
name: increased summary potential threshold
def: "increase in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice" [MGI:Nmice]
is_a: MP:0003471 ! abnormal summary potential threshold

[Term]
id: MP:0003473
name: decreased summary potential threshold
def: "reduction in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice" [MGI:Nmice]
synonym: "reduced summary potential threshold" EXACT []
is_a: MP:0003471 ! abnormal summary potential threshold

[Term]
id: MP:0003474
name: abnormal summary potential intensity
def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice" [MGI:Nmice]
is_a: MP:0003470 ! abnormal summary potential

[Term]
id: MP:0003475
name: increased summary potential intensity
def: "increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice" [MGI:Nmice]
is_a: MP:0003474 ! abnormal summary potential intensity

[Term]
id: MP:0003476
name: decreased summary potential intensity
def: "reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice" [MGI:Nmice]
synonym: "reduced summary potential intensity" EXACT []
is_a: MP:0003474 ! abnormal summary potential intensity

[Term]
id: MP:0003477
name: abnormal nerve fiber response
def: "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "abnormal nerve fibre response" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0003478
name: abnormal nerve fiber response threshold
def: "any change in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "abnormal nerve fibre response threshold" EXACT []
is_a: MP:0003477 ! abnormal nerve fiber response

[Term]
id: MP:0003479
name: abnormal nerve fiber response intensity
def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "abnormal nerve fibre response intensity" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003477 ! abnormal nerve fiber response

[Term]
id: MP:0003480
name: increased nerve fiber response intensity
def: "increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "increased nerve fibre response intensity" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003479 ! abnormal nerve fiber response intensity

[Term]
id: MP:0003481
name: decreased nerve fiber response intensity
def: "reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "decreased nerve fibre response intensity" EXACT []
synonym: "reduced nerve fiber response intensity" EXACT []
synonym: "reduced nerve fibre response intensity" EXACT []
is_a: MP:0003479 ! abnormal nerve fiber response intensity

[Term]
id: MP:0003482
name: increased nerve fiber response threshold
def: "increase in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "increased nerve fibre response threshold" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003478 ! abnormal nerve fiber response threshold

[Term]
id: MP:0003483
name: decreased nerve fiber response threshold
def: "reduction in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)" [MGI:Nmice]
synonym: "decreased nerve fibre response threshold" EXACT []
synonym: "reduced nerve fiber response threshold" EXACT []
synonym: "reduced nerve fibre response threshold" EXACT []
is_a: MP:0003478 ! abnormal nerve fiber response threshold

[Term]
id: MP:0003484
name: abnormal channel response
alt_id: MP:0002203
def: "anomalies in the electrophysiological recordings from ion channels" [MGI:Nmice]
synonym: "channel defects" EXACT []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0003485
name: abnormal channel response threshold
def: "any change in the value at which a stimulus first elicits a recordable response recorded from ion channels" [MGI:Nmice]
is_a: MP:0003484 ! abnormal channel response

[Term]
id: MP:0003486
name: abnormal channel response intensity
def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels" [MGI:Nmice]
is_a: MP:0003484 ! abnormal channel response

[Term]
id: MP:0003487
name: increased channel response intensity
def: "increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels" [MGI:Nmice]
is_a: MP:0003486 ! abnormal channel response intensity

[Term]
id: MP:0003488
name: decreased channel response intensity
def: "reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels" [MGI:Nmice]
synonym: "reduced channel response intensity" EXACT []
is_a: MP:0003486 ! abnormal channel response intensity

[Term]
id: MP:0003489
name: increased channel response threshold
def: "increase in the value at which a stimulus first elicits a recordable response recorded from ion channels" [MGI:Nmice]
is_a: MP:0003485 ! abnormal channel response threshold

[Term]
id: MP:0003490
name: decreased channel response threshold
def: "reduction in the value at which a stimulus first elicits a recordable response recorded from ion channels" [MGI:Nmice]
synonym: "reduced channel response threshold" EXACT []
is_a: MP:0003485 ! abnormal channel response threshold

[Term]
id: MP:0003491
name: abnormal voluntary movement
def: "anomaly in coordinated movements executed with a purpose and can be improved by learning and/or experience" [MGI:Nmice]
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0003492
name: abnormal involuntary movement
def: "anomaly in movements that occur independent of planning (e.g. reflexive behavior)" [MGI:Nmice]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0003493
name: parathyroid gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the parathyroid gland, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "hyperplastic parathyroid gland" EXACT []
synonym: "parathyroid hyperplasia" RELATED []
is_a: MP:0003112 ! enlarged parathyroid gland

[Term]
id: MP:0003494
name: parathyroid hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the parathyroid gland, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "hypoplastic parathyroid gland" EXACT []
is_a: MP:0003113 ! small parathyroid gland

[Term]
id: MP:0003495
name: increased parathyroid adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the parathyroid gland, occurring in a specific population in a given time period" [NCBI:matt]
is_a: MP:0010321 ! increased parathyroid gland tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0003496
name: increased thyroid adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the thyroid gland, occurring in a specific population in a given time period" [NCBI:matt]
is_a: MP:0010316 ! increased thyroid tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0003497
name: insensitivity to parathyroid hormone
def: "no changes in calcium homeostasis in response to endogenous or exogenous hormone" [NCBI:matt]
is_a: MP:0003638 ! abnormal response/metabolism to endogenous compounds

[Term]
id: MP:0003498
name: thyroid gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the thyroid gland, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "hyperplastic thyroid" EXACT []
synonym: "thyroid hyperplasia" RELATED []
is_a: MP:0005355 ! enlarged thyroid gland

[Term]
id: MP:0003499
name: thyroid gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the thyroid gland, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "hypoplastic thyroid gland" EXACT []
synonym: "thyroid hypoplasia" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002951 ! small thyroid gland

[Term]
id: MP:0003501
name: iodide oxidation defect
def: "thyroid defect in oxidation and organification of iodide" [NCBI:matt]
is_a: MP:0002876 ! abnormal thyroid gland physiology

[Term]
id: MP:0003502
name: increased activity of thyroid gland
def: "increased function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body" [NCBI:matt]
synonym: "hyperthyroidism" EXACT []
synonym: "increased activity of thyroid" EXACT []
is_a: MP:0002876 ! abnormal thyroid gland physiology

[Term]
id: MP:0003503
name: decreased activity of thyroid gland
def: "reduced function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body" [NCBI:matt]
synonym: "decreased activity of thyroid" EXACT []
synonym: "hypothyroidism" EXACT []
synonym: "reduced activity of thyroid" EXACT []
is_a: MP:0002876 ! abnormal thyroid gland physiology

[Term]
id: MP:0003504
name: thyroid gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [NCBI:matt]
synonym: "thyroid inflammation" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "thyroiditis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002876 ! abnormal thyroid gland physiology

[Term]
id: MP:0003505
name: increased prolactinoma incidence
def: "greater than the expected number of a pituitary adenoma characterized by secretion of prolactin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, MESH:C04.557.470.035.625, NCBI:matt]
is_a: MP:0002041 ! increased pituitary adenoma incidence
is_a: MP:0010350 ! increased pituitary adenohypophysis tumor incidence

[Term]
id: MP:0003506
name: acromegaly
def: "excessive secretion of growth hormone resulting in progressive enlargement of the face, hands, feet, head, and thorax; organomegaly and impaired glucose homeostasis may ensue" [ISBN:0-683-40008-8, MESH:C05.116.132.082, NCBI:matt]
synonym: "increased growth hormone secretion" EXACT []
is_a: MP:0001746 ! abnormal pituitary secretion

[Term]
id: MP:0003507
name: abnormal ovary physiology
def: "any functional anomaly of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MESH:A05.360.319.114.630, NCBI:matt]
synonym: "abnormal ovarian physiology" EXACT []
is_a: MP:0003699 ! abnormal female reproductive system physiology
is_a: MP:0013326 ! abnormal female reproductive gland physiology

[Term]
id: MP:0003508
name: abnormal circulating dihydrotestosterone level
def: "aberration in the blood concentration of a potent androgenic metabolite of testosterone" [MESH:D04.808.054.040.248, NCBI:matt]
synonym: "abnormal circulating level of stanolone" EXACT []
synonym: "abnormal circulating levels of dihydrotestosterone" RELATED []
is_a: MP:0009819 ! abnormal circulating androgen level

[Term]
id: MP:0003509
name: increased circulating dihydrotestosterone level
def: "greater than normal blood concentration of this potent androgenic metabolite of testosterone" [MESH:D04.808.054.040.248, NCBI:matt]
synonym: "increased circulating levels of dihydrotestosterone" EXACT []
is_a: MP:0003508 ! abnormal circulating dihydrotestosterone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0003510
name: decreased circulating dihydrotestosterone level
def: "reduction in the blood concentration of a potent androgenic metabolite of testosterone" [MESH:D04.808.054.040.248, NCBI:matt]
synonym: "decreased circulating levels of dihydrotestosterone" EXACT []
synonym: "reduced circulating levels of dihydrotestosterone" EXACT []
is_a: MP:0003508 ! abnormal circulating dihydrotestosterone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0003511
name: abnormal labium morphology
def: "any structural anomaly of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0003512
name: enlarged labia
def: "increased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "increased labia size" EXACT []
is_a: MP:0003511 ! abnormal labium morphology

[Term]
id: MP:0003513
name: small labia
def: "decreased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "decreased labia size" EXACT []
synonym: "reduced labia size" EXACT []
is_a: MP:0003511 ! abnormal labium morphology

[Term]
id: MP:0003514
name: interlabial sulcus
def: "the presence of grooves or furrows in the folds of skin which lips on both sides of the vaginal opening" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003511 ! abnormal labium morphology

[Term]
id: MP:0003515
name: abnormal labia majora morphology
def: "any structural anomaly of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003511 ! abnormal labium morphology

[Term]
id: MP:0003516
name: absent labia majora
def: "absence of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003515 ! abnormal labia majora morphology

[Term]
id: MP:0003517
name: enlarged labia majora
def: "increased size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "increased labia majora size" EXACT []
is_a: MP:0003515 ! abnormal labia majora morphology

[Term]
id: MP:0003518
name: small labia majora
def: "reduced size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "decreased labia majora size" EXACT []
synonym: "reduced labia majora size" EXACT []
is_a: MP:0003515 ! abnormal labia majora morphology

[Term]
id: MP:0003519
name: splayed labia majora
def: "flattened or spread out appearance of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003515 ! abnormal labia majora morphology

[Term]
id: MP:0003520
name: abnormal labia minora morphology
def: "any structural anomaly of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003511 ! abnormal labium morphology

[Term]
id: MP:0003521
name: absent labia minora
def: "absence of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003520 ! abnormal labia minora morphology

[Term]
id: MP:0003522
name: enlarged labia minora
def: "increased size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "increased labia minora size" EXACT []
is_a: MP:0003520 ! abnormal labia minora morphology

[Term]
id: MP:0003523
name: small labia minora
def: "reduced size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening" [NCBI:matt]
synonym: "decreased labia minora size" EXACT []
synonym: "reduced labia minora size" EXACT []
is_a: MP:0003520 ! abnormal labia minora morphology

[Term]
id: MP:0003524
name: splayed labia minora
def: "flattened or spread out appearance of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening" [NCBI:matt]
is_a: MP:0003520 ! abnormal labia minora morphology

[Term]
id: MP:0003525
name: vulva warts
def: "benign epithelial growths of the external genitalia of the female" [NCBI:matt]
synonym: "external female genitalia warts" EXACT []
synonym: "vulval warts" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0003526
name: vulva cyst
def: "presence of one or more abnormal membranous sacs in the vulva" [NCBI:matt]
synonym: "cystic external female genitalia" EXACT []
synonym: "cystic vulva" EXACT []
synonym: "vulva cysts" EXACT []
synonym: "vulval cyst" EXACT []
synonym: "vulval cysts" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003527
name: small vulva
def: "decreased size of the external genitalia of the female" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "decreased vulva size" EXACT []
synonym: "reduced vulva size" EXACT []
synonym: "small external female genitalia" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0003528
name: enlarged vulva
def: "increased size of the external genitalia of the female" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "enlarged external female genitalia" EXACT []
synonym: "increased vulva size" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0003529
name: enlarged clitoris
def: "increased size of the small, erectile body located at the anterior end of the vulva" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "clitorimegaly" EXACT []
synonym: "increased clitoris size" EXACT []
is_a: MP:0009100 ! abnormal clitoris size

[Term]
id: MP:0003530
name: small clitoris
def: "reduced size of the small, erectile body located at the anterior end of the vulva" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "decreased clitoris size" EXACT []
is_a: MP:0009100 ! abnormal clitoris size

[Term]
id: MP:0003531
name: abnormal vagina development
def: "abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva" [NCBI:matt]
synonym: "abnormal vaginal development" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0003533
name: bifid vagina
def: "cleft of the female reproductive canal located between the uterus and the vulva into two parts or branches" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "double vagina" EXACT []
synonym: "intact vaginal septum" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003534
name: blind vagina
def: "presence the female reproductive canal that ends in a sac and does not connect to internal genitalia" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003535
name: absent vagina
def: "absence of the female reproductive canal located between the uterus and the vulva" [NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003536
name: vagina dryness
def: "lack of the normal presence or reduced presence of secretions in the vagina" [NCBI:matt]
synonym: "vaginal dryness" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003537
name: hydrometrocolpos
def: "collection of fluid in the vagina; often due to a congenital obstruction" [NCBI:matt]
synonym: "hydrometrocolops" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003538
name: abnormal hymen development
def: "anomaly in the morphogenesis of the thin membrane which may partially occlude the opening of the vagina; often absent in normal females" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0001142 ! abnormal vagina orifice morphology

[Term]
id: MP:0003539
name: absent hymen
def: "absence of the thin membrane which may partially occlude the opening of the vagina" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003538 ! abnormal hymen development

[Term]
id: MP:0003540
name: imperforate hymen
def: "absence of the normal opening of the thin membrane which may partially occlude the opening of the vagina; here the opening is completely occluded" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0003538 ! abnormal hymen development

[Term]
id: MP:0003541
name: vaginal inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the vagina" [NCBI:matt]
synonym: "vaginitis" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0031162 ! abnormal vagina physiology

[Term]
id: MP:0003542
name: abnormal vascular endothelial cell development
def: "anomaly in the differentiation of the cells that line the vasculature" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000259 ! abnormal vascular development

[Term]
id: MP:0003543
name: abnormal vascular endothelial cell differentiation
def: "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003542 ! abnormal vascular endothelial cell development
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0003544
name: abnormal vascular endothelial cell migration
def: "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0003542 ! abnormal vascular endothelial cell development

[Term]
id: MP:0003545
name: increased alcohol consumption
def: "greater than normal consumption of alcohol" [RGD:cur]
is_a: MP:0001425 ! abnormal alcohol consumption
is_a: MP:0011941 ! increased fluid intake

[Term]
id: MP:0003546
name: decreased alcohol consumption
def: "less than normal consumption of alcohol" [RGD:cur]
synonym: "reduced alcohol consumption" EXACT []
is_a: MP:0001425 ! abnormal alcohol consumption
is_a: MP:0011942 ! decreased fluid intake

[Term]
id: MP:0003547
name: abnormal pulmonary pressure
def: "altered tension of the blood within the pulmonary arteries" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0003548
name: pulmonary hypertension
def: "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004012 ! increased pulmonary artery pressure

[Term]
id: MP:0003549
name: pulmonary hypotension
def: "sustained low pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004013 ! decreased pulmonary artery pressure

[Term]
id: MP:0003550
name: short perineum
def: "reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [NCBI:matt]
synonym: "decreased perineum length" EXACT []
is_a: MP:0005189 ! abnormal anogenital distance

[Term]
id: MP:0003551
name: blind perineal pouch
def: "opening in the perineum leading to a blind-ending sac" [NCBI:matt]
is_a: MP:0003315 ! abnormal perineum morphology

[Term]
id: MP:0003552
name: vagina cyst
def: "presence of one or more benign epithelial growths in the vagina" [NCBI:matt]
synonym: "cystic vagina" EXACT []
synonym: "vagina cysts" EXACT []
synonym: "vaginal cyst" EXACT []
synonym: "vaginal cysts" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003553
name: abnormal foreskin morphology
def: "any structural anomaly of the loose fold of skin that covers the penis" [NCBI:matt]
synonym: "abnormal prepuce morphology" EXACT []
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0003554
name: phimosis
def: "inability of the penis to protrude from the prepuce/foreskin; may be due to a narrow opening of the foreskin resulting in the inability to retract the distal foreskin over the glans penis" [MGI:mberry, NCBI:matt]
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0003555
name: chordee
def: "acute angulation of the penis upon erection; often painful and due to disease or congenital malformation" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0001379 ! abnormal penile erection
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0003557
name: absent vas deferens
alt_id: MP:0003556
def: "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "absent ductus deferens" EXACT []
synonym: "agenesis of vas deferens" EXACT []
synonym: "ductus deferens aplasia" EXACT []
synonym: "vas deferens aplasia" EXACT []
is_a: MP:0002769 ! abnormal vas deferens morphology

[Term]
id: MP:0003558
name: absent uterus
def: "absence of the female muscular organ of gestation" [NCBI:matt]
synonym: "absence of metra" EXACT []
synonym: "absence of uterus" EXACT []
synonym: "absent metra" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0003559
name: bifid uterus
def: "cleft of the female muscular organ of gestation into two parts or branches, often having the appearance of two lobes" [NCBI:matt]
synonym: "bifid metra" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0003560
name: osteoarthritis
def: "a type of arthritis that results in the breakdown and eventual loss of the articular cartilage of one or more joints" [https://orcid.org/0000-0003-4606-0597, J:95374]
synonym: "degenerative arthritis" EXACT []
synonym: "osteoarthrosis" EXACT []
is_a: MP:0002933 ! joint inflammation

[Term]
id: MP:0003561
name: rheumatoid arthritis
def: "an autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [ISBN:0-683-40008-8]
synonym: "osteoarthrosis deformans" EXACT []
is_a: MP:0001844 ! autoimmune response
is_a: MP:0002993 ! autoimmune arthritis

[Term]
id: MP:0003562
name: abnormal pancreatic beta cell physiology
def: "anomaly in the function of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas" [CL:0000169]
synonym: "abnormal insulin-secreting cell physiology" EXACT []
synonym: "abnormal pancreatic B cell physiology" EXACT []
is_a: MP:0010147 ! abnormal endocrine pancreas physiology

[Term]
id: MP:0003563
name: abnormal pancreatic alpha cell physiology
def: "anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal glucagon secreting cell physiology" EXACT []
synonym: "abnormal pancreatic A cell physiology" EXACT []
is_a: MP:0010147 ! abnormal endocrine pancreas physiology

[Term]
id: MP:0003564
name: abnormal insulin secretion
def: "anomaly in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [https://orcid.org/0000-0003-4606-0597, MESH:D06.472.699.587.740.625]
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0003562 ! abnormal pancreatic beta cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0003565
name: abnormal glucagon secretion
def: "anomaly in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [https://orcid.org/0000-0003-4606-0597, MESH:D06.472.699.587.469.500]
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0003563 ! abnormal pancreatic alpha cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0003566
name: abnormal cell adhesion
def: "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0003567
name: abnormal fetal cardiomyocyte proliferation
def: "anomaly in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cardiomyoblast proliferation" EXACT []
synonym: "abnormal foetal cardiomyocyte proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0002106 ! abnormal muscle physiology
is_a: MP:0011390 ! abnormal fetal cardiomyocyte physiology

[Term]
id: MP:0003568
name: uterus atresia
def: "congenital absence of the normal opening or lumen of the uterus" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "metra atresia" EXACT []
synonym: "metral atresia" EXACT []
synonym: "uterine atresia" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0003569
name: increased leiomyoma incidence
def: "greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "increased fibroid tumor incidence" EXACT []
synonym: "increased fibroid tumour incidence" EXACT []
synonym: "increased fibromyoma incidence" EXACT []
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010290 ! increased muscle tumor incidence

[Term]
id: MP:0003570
name: increased uterus leiomyoma incidence
def: "greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle of the uterus, occurring in a specific population in a given time period" [MESH:C04.557.450.590.450, NCBI:matt]
synonym: "increased fibroid uterus incidence" EXACT []
synonym: "increased uterine fibroid incidence" EXACT []
synonym: "increased uterine fibroma incidence" EXACT []
synonym: "increased uterine fibromyoma incidence" EXACT []
synonym: "increased uterine leiomyoma incidence" EXACT []
is_a: MP:0003569 ! increased leiomyoma incidence
is_a: MP:0009222 ! increased uterus tumor incidence

[Term]
id: MP:0003571
name: uterus rupture
def: "tearing of the uterine tissue; may be due to trauma or pregnancy complications" [MESH:C23.300.909, NCBI:matt]
synonym: "metra rupture" EXACT []
synonym: "metral rupture" EXACT []
synonym: "rupture of uterus" EXACT []
synonym: "uterine rupture" RELATED []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0003572
name: abnormal uterus development
def: "abnormal morphogenesis of the female muscular organ of gestation" [NCBI:matt]
synonym: "abnormal metra development" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0003574
name: abnormal oviduct morphology
def: "any structural anomaly of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fallopian tube morphology" EXACT []
synonym: "abnormal salpinges morphology" EXACT []
synonym: "abnormal salpinx morphology" EXACT []
synonym: "abnormal salpinx uterina morphology" EXACT []
synonym: "abnormal tuba fallopiana morphology" EXACT []
synonym: "abnormal tuba fallopii morphology" EXACT []
synonym: "abnormal tuba uterina morphology" EXACT []
synonym: "abnormal uterine tube morphology" EXACT []
synonym: "fallopian tube dysplasia" NARROW []
synonym: "oviduct dysplasia" NARROW []
is_a: MP:0009209 ! abnormal internal female genitalia morphology

[Term]
id: MP:0003575
name: absent oviduct
def: "absence of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent fallopian tubes" EXACT []
synonym: "absent salpinges" EXACT []
synonym: "absent salpinx" EXACT []
synonym: "absent salpinx uterina" EXACT []
synonym: "absent tuba fallopiana" EXACT []
synonym: "absent tuba fallopii" EXACT []
synonym: "absent tuba uterina" EXACT []
synonym: "absent uterine tube" EXACT []
synonym: "agenesis of fallopian tubes" EXACT []
synonym: "aplasia of fallopian tubes" EXACT []
synonym: "oviduct agenesis" EXACT []
synonym: "oviduct aplasia" EXACT []
is_a: MP:0003574 ! abnormal oviduct morphology

[Term]
id: MP:0003576
name: oviduct hypoplasia
alt_id: MP:0003577
def: "decrease in the number of normal cells in normal arrangement in the oviduct, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "fallopian tube hypoplasia" EXACT []
synonym: "hypoplastic oviduct" EXACT []
synonym: "rudimentary fallopian tubes" EXACT []
synonym: "rudimentary oviduct" EXACT []
synonym: "rudimentary salpinges" EXACT []
synonym: "rudimentary salpinx" EXACT []
synonym: "rudimentary salpinx uterina" EXACT []
synonym: "rudimentary tuba fallopiana" EXACT []
synonym: "rudimentary tuba fallopii" EXACT []
synonym: "rudimentary tuba uterina" EXACT []
synonym: "rudimentary uterine tube" EXACT []
synonym: "salpinges hypoplasia" EXACT []
synonym: "salpinx hypoplasia" EXACT []
synonym: "salpinx uterina hypoplasia" EXACT []
synonym: "tuba fallopiana hypoplasia" EXACT []
synonym: "tuba fallopii hypoplasia" EXACT []
synonym: "tuba uterina hypoplasia" EXACT []
synonym: "uterine tube hypoplasia" EXACT []
is_a: MP:0009070 ! small oviduct

[Term]
id: MP:0003578
name: absent ovary
def: "absence of the female reproductive gland containing the germ cells" [NCBI:matt]
synonym: "bilateral ovarian agenesis" EXACT []
synonym: "bilateral ovarian aplasia" EXACT []
synonym: "female agonadism" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology
is_a: MP:0005644 ! agonadal

[Term]
id: MP:0003579
name: increased ovarian carcinoma incidence
def: "greater than the expected number of a malignant neoplasm arising from ovarian tissue, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "ovarian carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0008000 ! increased ovary tumor incidence

[Term]
id: MP:0003580
name: increased fibroma incidence
alt_id: MP:0003297
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue, in a specific population in a given time period" [MESH:C04.557.450.565.590.340]
synonym: "fibromatosis" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence

[Term]
id: MP:0003581
name: increased ovarian fibroma incidence
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the ovary, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, MESH:C04.557.450.565.590.340, NCBI:matt]
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0008000 ! increased ovary tumor incidence

[Term]
id: MP:0003582
name: abnormal ovary development
def: "abnormal morphogenesis of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MESH:A05.360.319.114.630]
is_a: MP:0001126 ! abnormal ovary morphology
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0003584
name: bifid ureter
def: "two ureters join before draining into the urinary bladder; a duplex kidney with a bifid renal pelvis or bifid ureter ensues when a single ureteral bud bifurcates before the ampulla bifurcates" [https://orcid.org/0000-0002-6490-7723]
synonym: "partial ureter duplication" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003585
name: large ureter
def: "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "megaureter" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003586
name: dilated ureter
def: "abnormal distention of one or both ureters due to accumulation of fluid" [NCBI:matt]
synonym: "dilated ureters" EXACT []
synonym: "ureter dilation" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003587
name: ureter obstruction
def: "a partial or total blockage in any part of the ureter causing obstruction of urine flow from the kidney to the urinary bladder; may be congenital, acquired, unilateral, bilateral, acute or chronic" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
synonym: "obstructive uropathy" EXACT []
synonym: "ureteral obstruction" EXACT []
synonym: "ureteral stasis" EXACT []
synonym: "ureteric obstruction" EXACT []
xref: Fyler:4492
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003588
name: ureter stenosis
def: "abnormal narrowing or constriction of the ureter" [NCBI:matt]
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003589
name: abnormal ureter physiology
def: "any functional anomaly of the tube that conducts the urine from the renal pelvis to the bladder" [NCBI:matt]
is_a: MP:0005502 ! abnormal renal/urinary system physiology

[Term]
id: MP:0003590
name: OBSOLETE ureteral reflux
def: "OBSOLETE retrograde movement of urine from the bladder to the kidney" [NCBI:matt]
is_obsolete: true
replaced_by: MP:0001948

[Term]
id: MP:0003591
name: urethra atresia
def: "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [NCBI:matt]
is_a: MP:0000537 ! abnormal urethra morphology

[Term]
id: MP:0003592
name: urethra stricture
def: "abnormal narrowing or constriction at one or more points in the urethra" [https://orcid.org/0000-0002-6490-7723]
comment: Urethral stricture is almost invariably restricted to males and often secondary to injury, inflammation, tumors or any other cause of scarring; whether congenital or acquired, urethral strictures may compromise voiding and cause incontinence, bleeding, stones or even renal failure.
synonym: "urethra stenosis" EXACT []
synonym: "urethral constriction" EXACT []
synonym: "urethral stricture" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology

[Term]
id: MP:0003593
name: urethrovaginal fistula
def: "an abnormal anatomical passage connecting the urethra and the vagina" [MESH:C23.300.575, NCBI:matt]
synonym: "urethro-vaginal fistula" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0003594
name: small urethra
def: "decreased size or length of the canal that leads from the bladder and discharges urine externally" [NCBI:matt]
is_a: MP:0000537 ! abnormal urethra morphology

[Term]
id: MP:0003595
name: epididymal cyst
def: "presence of one or more benign growths in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [NCBI:matt]
synonym: "cystic epididymis" EXACT []
synonym: "epididymal cysts" EXACT []
synonym: "epididymis cyst" EXACT []
synonym: "epididymis cysts" EXACT []
is_a: MP:0002631 ! abnormal epididymis morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003596
name: epididymis inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [NCBI:matt]
synonym: "epididymal inflammation" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "epididymitis" EXACT []
synonym: "inflamed epididymides" EXACT []
synonym: "inflamed epididymis" EXACT []
synonym: "inflammation of the epididymides" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0014190 ! abnormal epididymis physiology

[Term]
id: MP:0003597
name: increased epididymal cystadenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising from epididymal tissue, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
synonym: "increased epididymal cystoma incidence" EXACT []
is_a: MP:0002631 ! abnormal epididymis morphology
is_a: MP:0010287 ! increased reproductive system tumor incidence
is_a: MP:0013751 ! increased cystadenoma incidence

[Term]
id: MP:0003598
name: epispadia
def: "congenital absence of the upper wall of the urethra, occurring in both sexes, but more often in the male, with the urethral opening somewhere on the dorsum of the penis at any point below the internal sphincter; in females, the malformed urethral opening is often located aberrantly" [https://orcid.org/0000-0002-6490-7723]
synonym: "epispadias" EXACT []
synonym: "hyperspadia" EXACT []
synonym: "hyperspadias" EXACT []
is_a: MP:0011796 ! abnormal external urethral orifice morphology

[Term]
id: MP:0003599
name: large penis
def: "enlarged size of the organ of copulation and urination in the male" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "increased penis size" EXACT []
synonym: "macropenis" EXACT []
synonym: "macrophallus" EXACT []
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0003600
name: ectopic kidney
def: "a kidney located outside of its normal position usually due to failed migration of the ureteral bud and developing metanephric blastema to the renal fossa; the most common example of renal ectopia is a pelvic kidney; other sites of ectopic kidneys include the iliac region, the abdomen, the chest, and, in some cases, the contralateral side, referred to as crossed" [https://orcid.org/0000-0002-6490-7723]
synonym: "renal ectopia" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003601
name: bifid kidney
def: "cleft of the kidney into two parts or branches, often having the appearance of two lobes" [NCBI:matt]
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003602
name: increased renal hamartoma incidence
def: "greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the kidney, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue" [NCBI:matt]
synonym: "renal hamartoma" RELATED []
is_a: MP:0010294 ! increased kidney tumor incidence
is_a: MP:0010306 ! increased hamartoma incidence

[Term]
id: MP:0003603
name: increased renal hemangioblastoma incidence
def: "greater than the expected number of a benign cyst-like tumor of the kidney that is composed of multiple capillary and sinusoidal channels lined with endothelial cells, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "increased renal haemangioblastoma incidence" RELATED []
synonym: "renal haemangioblastoma" RELATED []
synonym: "renal hemangioblastoma" RELATED []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0008021 ! increased blastoma incidence
is_a: MP:0010294 ! increased kidney tumor incidence

[Term]
id: MP:0003604
name: single kidney
def: "presence of only one of the paired organs responsible for urine secretion" [NCBI:matt]
subset: CvDC_Terms
synonym: "unilateral kidney agenesis" EXACT []
synonym: "unilateral renal agenesis" EXACT []
xref: Fyler:4509
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003605
name: fused kidneys
def: "a defect in which there is a single malformed organ resulting from partial or complete fusion of the two renal anlage" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, NCBI:matt]
subset: CvDC_Terms
synonym: "cake kidney" NARROW []
synonym: "disc kidney" NARROW []
synonym: "disk kidney" NARROW []
synonym: "fusion of kidneys" EXACT []
synonym: "horseshoe kidney" NARROW []
synonym: "kidney fusion" EXACT []
xref: Fyler:4507
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003606
name: kidney failure
def: "failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur" [NCBI:matt]
synonym: "renal failure" EXACT []
synonym: "renal insufficiency" BROAD []
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0003607
name: abnormal prostate gland physiology
def: "any functional anomaly of the gland in males that secretes part of the seminiferous fluid" [ISBN:0-683-40008-8]
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0013327 ! abnormal male reproductive gland physiology
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0003608
name: prostate gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [MGI:cwg]
synonym: "prostate inflammation" EXACT []
synonym: "prostatitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003607 ! abnormal prostate gland physiology

[Term]
id: MP:0003609
name: small scrotum
def: "reduced size of the external sac of skin that encloses the testes" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "decreased scrotum size" EXACT []
is_a: MP:0002669 ! abnormal scrotum morphology

[Term]
id: MP:0003610
name: scrotum hyperplasia
def: "increase in the number of normal cells in normal arrangement in the external sac of skin that encloses the testes, typically resulting in increased size" [NCBI:matt]
synonym: "hyperplastic scrotum" EXACT []
is_a: MP:0001150 ! enlarged scrotum

[Term]
id: MP:0003611
name: scrotum hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the scrotum, typically resulting in decreased size" [NCBI:matt]
synonym: "hypoplastic scrotum" EXACT []
synonym: "scrotal hypoplasia" EXACT []
is_a: MP:0003609 ! small scrotum

[Term]
id: MP:0003612
name: bifid scrotum
def: "cleft of the scrotum into two parts or branches, often having the appearance of two lobes" [NCBI:matt]
is_a: MP:0002669 ! abnormal scrotum morphology

[Term]
id: MP:0003613
name: abnormal kidney medulla development
def: "anomaly in the differentiation of the inner portion of the kidney consisting of the renal pyramids" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal renal medulla development" EXACT []
is_a: MP:0000527 ! abnormal kidney development
is_a: MP:0003014 ! abnormal kidney medulla morphology

[Term]
id: MP:0003614
name: urinary bladder prolapse
def: "hernial protrusion of the urinary bladder, usually through the vaginal wall" [https://orcid.org/0000-0002-6490-7723, NCBI:matt]
synonym: "cystocele" EXACT []
synonym: "cystocoele" EXACT []
synonym: "fallen bladder" EXACT []
synonym: "prolapsed bladder" EXACT []
synonym: "vesical hernia" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0003615
name: urinary bladder diverticulum
def: "a pouch or sac protruding from the urinary bladder wall" [NCBI:matt]
synonym: "bladder diverticulum" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0003616
name: abnormal urachus morphology
def: "any structural anomaly of the fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0001725 ! abnormal umbilical cord morphology

[Term]
id: MP:0003617
name: urinary bladder hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the urinary bladder, typically resulting in decreased size" [NCBI:matt]
synonym: "cystis urinaria hypoplasia" EXACT []
synonym: "hypoplastic urinary bladder" EXACT []
synonym: "urocyst hypoplasia" EXACT []
synonym: "urocystis hypoplasia" EXACT []
synonym: "vesica hypoplasia" EXACT []
synonym: "vesica urinaria hypoplasia" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0003618
name: uterine cervical atresia
def: "narrowing of the cervical opening" [NCBI:matt]
synonym: "canalis cervicis uteri atresia" EXACT []
synonym: "caudal segment of uterus atresia" EXACT []
synonym: "cervical atresia" BROAD []
synonym: "cervical canal atresia" EXACT []
synonym: "cervical canal of uterus atresia" EXACT []
synonym: "cervix atresia" BROAD []
synonym: "cervix uteri atresia" EXACT []
synonym: "neck of uterus atresia" EXACT []
is_a: MP:0001135 ! abnormal uterine cervix morphology

[Term]
id: MP:0003619
name: abnormal urine color
def: "any alteration from the usual straw-coloration of the urine" [NCBI:matt]
synonym: "abnormal urine colour" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0003620
name: oliguria
def: "a reduction in the volume of urine produced and excreted; however, some urine is still produced" [NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
synonym: "low urine output" EXACT []
synonym: "oliguresis" EXACT []
is_a: MP:0031358 ! decreased urine output

[Term]
id: MP:0003621
name: dysuria
def: "difficult or painful urination" [NCBI:matt]
is_a: MP:0001756 ! abnormal urination

[Term]
id: MP:0003622
name: ischuria
def: "upon urination, some urine is retained in the bladder instead of being excreted" [NCBI:matt]
synonym: "incomplete emptying of bladder" EXACT []
synonym: "urinary retention" EXACT []
is_a: MP:0001756 ! abnormal urination
is_a: MP:0010386 ! abnormal urinary bladder physiology

[Term]
id: MP:0003623
name: hydrocele
def: "accumulation of fluid around testes" [NCBI:matt]
synonym: "hydrocele testis" EXACT []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0003624
name: anuria
alt_id: MP:0002755
def: "inability to form or excrete urine" [NCBI:matt]
synonym: "failure to urinate" EXACT []
synonym: "inability to micturate" EXACT []
synonym: "inability to urinate" EXACT []
is_a: MP:0031358 ! decreased urine output

[Term]
id: MP:0003625
name: kidney medulla hyperplasia
def: "increase in the number of normal cells in normal arrangement in the kidney medulla, typically resulting in increased size" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "hyperplastic renal medulla" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology

[Term]
id: MP:0003626
name: kidney medulla hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the kidney medulla, typically resulting in decreased size" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "hypoplastic kidney medulla" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology

[Term]
id: MP:0003627
name: abnormal leukocyte tethering or rolling
def: "anomaly in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal leucocyte tethering" EXACT []
synonym: "abnormal leucocyte tethering or rolling" EXACT []
synonym: "abnormal leukocyte tethering" EXACT []
synonym: "abnormal lymphocyte rolling" NARROW []
is_a: MP:0003628 ! abnormal leukocyte adhesion
is_a: MP:0009858 ! abnormal cellular extravasation

[Term]
id: MP:0003628
name: abnormal leukocyte adhesion
def: "anomaly in the number of or process by which leukocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal leucocyte adhesion" EXACT []
synonym: "abnormal lymphocyte adhesion" NARROW []
synonym: "abnormal lymphocyte firm adhesion" EXACT []
is_a: MP:0003156 ! abnormal leukocyte migration

[Term]
id: MP:0003630
name: abnormal urothelium morphology
def: "any structural anomaly of the epithelial lining of the lumen of the organs of the urinary tract" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0003631
name: nervous system phenotype
alt_id: MP:0005368
alt_id: MP:0005383
def: "the observable morphological and physiological characteristics of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]
synonym: "central nervous system phenotype" NARROW []
synonym: "CNS phenotype" NARROW []
synonym: "peripheral nervous system phenotype" NARROW []
synonym: "PNS phenotype" NARROW []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0003632
name: abnormal nervous system morphology
alt_id: MP:0000769
alt_id: MP:0000957
alt_id: MP:0002153
alt_id: MP:0002157
alt_id: MP:0002170
alt_id: MP:0002171
def: "any structural anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal central nervous system morphology" NARROW []
synonym: "abnormal peripheral nervous system" NARROW []
synonym: "abnormal peripheral nervous system morphology" NARROW []
synonym: "central nervous system abnormalities" NARROW []
synonym: "central nervous system anomaly" NARROW []
synonym: "central nervous system defects" NARROW []
synonym: "central nervous system: other dysmorphology" NARROW []
synonym: "nervous system dysplasia" NARROW []
synonym: "neurologic malformation" NARROW []
synonym: "other abnormal central nervous system morphology" NARROW []
synonym: "peripheral nervous system abnormalities" NARROW []
synonym: "peripheral nervous system abnormality" NARROW []
synonym: "peripheral nervous system anomaly" NARROW []
synonym: "peripheral nervous system defects" NARROW []
synonym: "peripheral nervous system: dysmorphology" NARROW []
xref: Fyler:4135
xref: Fyler:4300
xref: GO:0007417
xref: MGI:2173613
xref: MGI:2173617
is_a: MP:0003631 ! nervous system phenotype

[Term]
id: MP:0003633
name: abnormal nervous system physiology
alt_id: MP:0000945
alt_id: MP:0001887
alt_id: MP:0001910
alt_id: MP:0001918
alt_id: MP:0002155
alt_id: MP:0002158
def: "any functional anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain function" NARROW []
synonym: "abnormal central nervous system physiology" NARROW []
synonym: "abnormal peripheral nervous system physiology" NARROW []
synonym: "central nervous system functional abnormalities" NARROW []
synonym: "central nervous system: other functional anomalies" NARROW []
synonym: "peripheral nervous system: functional anomalies" NARROW []
xref: MGI:2173615
xref: MGI:2173618
is_a: MP:0003631 ! nervous system phenotype

[Term]
id: MP:0003634
name: abnormal glial cell morphology
def: "any structural anomaly of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MESH:A08.637]
synonym: "abnormal glia morphology" EXACT []
synonym: "abnormal neuroglia morphology" EXACT []
synonym: "glial cell dysplasia" NARROW []
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0003635
name: abnormal synaptic transmission
alt_id: MP:0002202
def: "defect in the communication from a neuron to a target across a synapse" [MESH:G04.335.880.850]
synonym: "abnormal neurotransmission" EXACT []
is_a: MP:0021009 ! abnormal synaptic physiology

[Term]
id: MP:0003636
name: obsolete absence of hair cells
def: "OBSOLETE. absence of the sensory epithelial cells of the inner ear" [ISBN:0-683-40008-8]
is_obsolete: true
consider: MP:0004325
consider: MP:0004405

[Term]
id: MP:0003637
name: cochlear ganglion hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the cochlear ganglion, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic cochlear ganglion" EXACT []
synonym: "reduced number of spiral ganglion cells" EXACT []
synonym: "spiral ganglion hypoplasia" EXACT []
is_a: MP:0003986 ! small cochlear ganglion

[Term]
id: MP:0003638
name: abnormal response/metabolism to endogenous compounds
def: "altered ability or inability to metabolize or respond to substances normally present in the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal metabolism of endogenous compounds" EXACT []
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0003639
name: abnormal response to vitamins
def: "altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body" [MESH:D27.505.696.377.605.600]
synonym: "abnormal metabolism of vitamins" EXACT []
is_a: MP:0003638 ! abnormal response/metabolism to endogenous compounds
is_a: MP:0004019 ! abnormal vitamin homeostasis

[Term]
id: MP:0003641
name: small lung
def: "reduced size of the lung compared to controls" [https://orcid.org/0000-0003-4606-0597, J:95332]
synonym: "decreased lung size" EXACT []
is_a: MP:0004881 ! abnormal lung size

[Term]
id: MP:0003642
name: absent seminal vesicle
def: "absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [ISBN:0-683-40008-8]
synonym: "absent seminal gland" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0003643
name: spleen atrophy
def: "acquired diminution of the size of the spleen associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic spleen" EXACT []
synonym: "splenic atrophy" EXACT []
is_a: MP:0000692 ! small spleen

[Term]
id: MP:0003644
name: thymus atrophy
def: "acquired diminution of the size of the thymus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic thymus" EXACT []
synonym: "atrophied thymus" EXACT []
synonym: "thymic atrophy" EXACT []
is_a: MP:0000706 ! small thymus

[Term]
id: MP:0003645
name: increased pancreatic beta cell number
def: "greater than normal number of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
synonym: "increased number of pancreatic beta cells" RELATED []
is_a: MP:0020578 ! abnormal pancreatic beta cell number

[Term]
id: MP:0003646
name: increased muscle fatigability
def: "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
synonym: "decreased resistance to muscle fatigue" EXACT []
synonym: "increased muscle fatiguability" EXACT []
synonym: "increased muscle fatigue" EXACT []
synonym: "increased susceptibility to muscle fatigue" EXACT []
synonym: "reduced resistance to muscle fatigue" EXACT []
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0003647
name: absent oligodendrocytes
def: "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
synonym: "absent oligodendroglia" EXACT []
synonym: "absent oligodendroglial cells" EXACT []
synonym: "absent oligoglia" EXACT []
synonym: "absent oligoglia cells" EXACT []
is_a: MP:0009808 ! decreased oligodendrocyte number

[Term]
id: MP:0003648
name: abnormal radial glial cell morphology
def: "any structural anomaly of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal radial glia" EXACT []
is_a: MP:0000952 ! abnormal CNS glial cell morphology
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0003649
name: decreased heart right ventricle size
def: "less than average size of the right ventricle compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased right ventricle size" EXACT []
synonym: "reduced right ventricle" EXACT []
is_a: MP:0010577 ! abnormal heart right ventricle size
is_a: MP:0031544 ! decreased heart ventricle size

[Term]
id: MP:0003651
name: abnormal axon extension
def: "abnormality in the ability of an axon to exhibit long distance growth of a single axon process from a neuron cell body involved in cellular development" [GO:0048675, https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal axon elongation" EXACT []
synonym: "abnormal axon outgrowth" EXACT []
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0003652
name: abnormal skin turgor
def: "anomaly in the ability of the skin to resist deformation; influential factors include dehydration and age" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal turgor" EXACT []
is_a: MP:0001191 ! abnormal skin condition

[Term]
id: MP:0003653
name: decreased skin turgor
def: "reduced ability of the skin to resist deformation; influential factors include dehydration and age" [https://orcid.org/0000-0003-3691-0324]
synonym: "poor skin turgor" EXACT []
synonym: "poor turgor" EXACT []
synonym: "reduced skin turgor" EXACT []
is_a: MP:0003652 ! abnormal skin turgor

[Term]
id: MP:0003654
name: nasal bone hyperplasia
def: "increase in the number of normal cells in normal arrangement in the bone that forms the nasal bridge, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic nasal bone" EXACT []
is_a: MP:0004474 ! enlarged nasal bone

[Term]
id: MP:0003655
name: absent pancreas
def: "absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0003656
name: abnormal erythrocyte physiology
alt_id: MP:0012383
def: "aberrant measurable or observable characteristic related to the function of or processes in the cells in the blood that carry oxygen, red blood cells" [MPD:Molly]
synonym: "abnormal red blood cell physiology" EXACT []
is_a: MP:0012382 ! abnormal blood cell physiology

[Term]
id: MP:0003657
name: abnormal erythrocyte osmotic lysis
def: "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal erythrocyte fragility" EXACT []
synonym: "abnormal erythrocyte lysis" BROAD []
synonym: "abnormal erythroid stress" EXACT []
is_a: MP:0010163 ! hemolysis

[Term]
id: MP:0003658
name: abnormal capillary morphology
def: "any structural anomaly of the small branching blood vessels that form a network between the arterioles and venules, where the exchange of water, oxygen, carbon dioxide, and other nutrient and waste chemical substances occurs between the blood and the surrounding tissues" [http://en.wikipedia.org/wiki/Capillary, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal capillaries" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0003659
name: abnormal lymph circulation
def: "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0002128 ! abnormal blood circulation
is_a: MP:0010368 ! abnormal lymphatic system physiology

[Term]
id: MP:0003660
name: chylothorax
def: "an accumulation of chyle in the pleural space; chyle is fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels" [ISBN:0-683-40008-8]
synonym: "chylopleura" EXACT []
synonym: "chylous hydrothorax" EXACT []
is_a: MP:0010334 ! pleural effusion

[Term]
id: MP:0003661
name: abnormal locus ceruleus morphology
def: "any structural anomaly of a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [ISBN:0838580343]
synonym: "abnormal locus coeruleus morphology" EXACT []
is_a: MP:0000848 ! abnormal pons morphology

[Term]
id: MP:0003662
name: abnormal long bone epiphyseal plate proliferative zone
def: "any anomaly of the germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal long bone epiphysial plate proliferative zone" RELATED []
is_a: MP:0000164 ! abnormal cartilage development
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0003663
name: abnormal thermosensation
def: "defect in the ability to sense or display a preference for a given temperature" [https://orcid.org/0009-0005-7755-8314, J:96549]
synonym: "abnormal thermal preference" EXACT []
synonym: "impaired thermosensation" EXACT []
is_a: MP:0002067 ! abnormal sensory capabilities/reflexes/nociception

[Term]
id: MP:0003664
name: ocular pterygium
def: "abnormal mass of hypertrophied bulbar subconjunctival tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea towards the pupil" [https://orcid.org/0009-0005-7755-8314, ISBN:0-683-40008-8]
synonym: "pterygia" BROAD []
synonym: "Surfer's eye" EXACT []
synonym: "web eye" EXACT []
is_a: MP:0001310 ! abnormal conjunctiva morphology

[Term]
id: MP:0003665
name: endophthalmitis
def: "inflammation of the internal structures of the tissues in the eyeball" [https://orcid.org/0009-0005-7755-8314, J:96018]
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0003666
name: impaired sperm capacitation
def: "reduced ability or inability of spermatozoa to undergo the series of morphological and molecular maturational processes in the female genital tract that enable them to penetrate and fertilize an egg" [GO:0048240, J:96669]
is_a: MP:0013286 ! abnormal sperm capacitation

[Term]
id: MP:0003667
name: increased hemangiosarcoma incidence
def: "higher than normal incidence of a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, MESH:C04.557.450.795.390]
synonym: "angiosarcoma" EXACT []
synonym: "haemangiosarcoma" RELATED []
synonym: "hemangiosarcoma" RELATED []
synonym: "increased haemangiosarcoma incidence" EXACT []
is_a: MP:0002032 ! increased sarcoma incidence

[Term]
id: MP:0003668
name: abnormal periodontal ligament morphology
def: "any structural anomaly of the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal periodontium ligament" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
is_a: MP:0005504 ! abnormal ligament morphology
is_a: MP:0030131 ! abnormal periodontium morphology

[Term]
id: MP:0003669
name: periodontal ligament hypercellularity
def: "increased cell density of the periodontal ligament" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003668 ! abnormal periodontal ligament morphology

[Term]
id: MP:0003670
name: dilated renal glomerular capsule
def: "stretched or widened aperture of the expanded beginning of a nephron that contains the glomerulus" [https://orcid.org/0000-0002-6490-7723]
synonym: "Bowman's capsule dilation" EXACT []
synonym: "dilated Bowman's capsule" EXACT []
synonym: "dilated Bowman's capsules" EXACT []
synonym: "dilated renal glomerular capsules" EXACT []
synonym: "renal glomerular capsule dilation" EXACT []
is_a: MP:0002828 ! abnormal renal glomerular capsule morphology

[Term]
id: MP:0003671
name: abnormal eyelid aperture
def: "any anomaly in the normal distance from one eyelid to the other, or closure of the eyes" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal blepharon fissure size" RELATED []
synonym: "abnormal eye lid aperture" EXACT []
synonym: "abnormal eyelid opening" EXACT []
synonym: "abnormal palpebral fissure size" RELATED []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0003672
name: abnormal ureter development
def: "any anomaly in the differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000534 ! abnormal ureter morphology
is_a: MP:0003942 ! abnormal urinary system development

[Term]
id: MP:0003673
name: abnormal inguinal canal morphology
def: "any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively" [ISBN:0-683-40008-8, MESH:A01.047.412]
synonym: "inguinal canal dysplasia" RELATED []
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0003674
name: oxidative stress
def: "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MESH:G06.535.710]
synonym: "increased reactive oxygen species production" RELATED []
synonym: "increased ROS production" RELATED []
is_a: MP:0003186 ! abnormal redox activity

[Term]
id: MP:0003675
name: kidney cyst
alt_id: MP:0005347
def: "presence of one or more abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "cystic kidney" EXACT []
synonym: "cystic kidneys" EXACT []
synonym: "kidney cysts" EXACT []
synonym: "renal cyst" EXACT []
synonym: "renal cysts" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003677
name: abnormal ear lobe morphology
def: "any structural anomaly in the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0003678
name: absent ear lobes
def: "missing the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage" [NCBI:matt]
synonym: "absence of ear lobes" EXACT []
is_a: MP:0003677 ! abnormal ear lobe morphology

[Term]
id: MP:0003679
name: ear lobe hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ear lobe, typically resulting in decreased size" [NCBI:matt]
synonym: "hypoplastic ear lobes" EXACT []
is_a: MP:0003677 ! abnormal ear lobe morphology

[Term]
id: MP:0003680
name: thick ear lobes
def: "an increase in the fleshiness of the ear lobes" [NCBI:matt]
synonym: "fleshy earlobes" EXACT []
is_a: MP:0003677 ! abnormal ear lobe morphology

[Term]
id: MP:0003681
name: protruding ear lobes
def: "ear lobes that project outward" [NCBI:matt]
synonym: "protruding lobules" EXACT []
is_a: MP:0003677 ! abnormal ear lobe morphology

[Term]
id: MP:0003682
name: linear crease in ear lobe
def: "appearance of fold-like marks in the ear lobe" [NCBI:matt]
synonym: "linear ear lobe creases" EXACT []
is_a: MP:0003677 ! abnormal ear lobe morphology

[Term]
id: MP:0003683
name: prominent ear lobes
def: "conspicuous appearance of the ear lobes" [NCBI:matt]
is_a: MP:0003681 ! protruding ear lobes

[Term]
id: MP:0003684
name: abnormal inferior olivary complex morphology
def: "any structural anomaly in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [ISBN:0838580343]
synonym: "abnormal inferior olivary nucleus morphology" EXACT []
synonym: "abnormal inferior olive morphology" EXACT []
synonym: "abnormal oliva morphology" EXACT []
is_a: MP:0000846 ! abnormal medulla oblongata morphology

[Term]
id: MP:0003685
name: abnormal cardiac ganglion morphology
def: "any structural anomaly of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery" [ISBN:0-683-40008-8]
synonym: "abnormal cardiac ganglia morphology" EXACT []
synonym: "abnormal Wrisberg ganglion morphology" EXACT []
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology

[Term]
id: MP:0003686
name: abnormal eye muscle morphology
def: "any structural anomaly of the muscles of the eye" [https://orcid.org/0000-0003-4606-0597]
synonym: "eye muscle dysplasia" NARROW []
synonym: "ocular muscle dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0003687
name: abnormal intraocular muscle morphology
def: "any structural anomaly of the smooth muscles within the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "abnormal intra-ocular muscle morphology" EXACT []
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0003686 ! abnormal eye muscle morphology

[Term]
id: MP:0003688
name: ophthalmoparesis
def: "loss of strength in the muscles that control eye movement" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0000747 ! muscle weakness
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0003689
name: ophthalmoplegia
def: "paralysis of the ocular muscles" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0003690
name: abnormal glial cell physiology
def: "any functional anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MESH:A08.637]
synonym: "abnormal glial cell function" EXACT []
synonym: "abnormal neuroglia physiology" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0003691
name: abnormal microglial cell physiology
def: "any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques" [PMID:16322748]
is_a: MP:0002451 ! abnormal macrophage physiology
is_a: MP:0003690 ! abnormal glial cell physiology

[Term]
id: MP:0003692
name: xanthoma
def: "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0003693
name: abnormal blastocyst hatching
def: "any anomaly of the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [GO:0001835]
synonym: "abnormal embryo hatching" RELATED []
is_a: MP:0009781 ! abnormal preimplantation embryo development

[Term]
id: MP:0003694
name: failure of blastocyst to hatch from the zona pellucida
def: "the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, fails to occur" [GO:0001835]
is_a: MP:0003693 ! abnormal blastocyst hatching

[Term]
id: MP:0003695
name: delayed blastocyst hatching from the zona pellucida
def: "the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, occurs later in development than expected" [GO:0001835]
is_a: MP:0003693 ! abnormal blastocyst hatching

[Term]
id: MP:0003696
name: abnormal zona pellucida morphology
def: "any structural anomaly of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001125 ! abnormal oocyte morphology

[Term]
id: MP:0003697
name: absent zona pellucida
def: "missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003696 ! abnormal zona pellucida morphology

[Term]
id: MP:0003698
name: abnormal male reproductive system physiology
def: "any functional anomaly of the male organs associated with producing offspring" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0003699
name: abnormal female reproductive system physiology
def: "any functional anomaly of the female organs associated with producing offspring" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0003700
name: abnormal oviduct transport
def: "increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus" [https://orcid.org/0000-0003-4606-0597, J:97633]
is_a: MP:0012018 ! abnormal oviduct physiology

[Term]
id: MP:0003701
name: elevated level of mitotic sister chromatid exchange
def: "increased number of crossovers between sister chromatids during mitosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes; normally crossover exchanges are supressed during mitosis and only occur in meiosis" [MGI:hdene, PMID:15831450]
synonym: "elevated SCE" EXACT []
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0003702
name: abnormal chromosome morphology
def: "any structural anomaly of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information" [MGI:hdene]
subset: CvDC_Terms
xref: Fyler:4013
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0003703
name: abnormal vestibulocochlear ganglion morphology
alt_id: MP:0001090
def: "any structural anomaly of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal spiral ganglion" BROAD []
synonym: "abnormal vestibular cochlear ganglion" EXACT []
synonym: "abnormal vestibular cochlear ganglion morphology" EXACT []
synonym: "abnormal vestibulocochlear ganglia morphology" EXACT []
is_a: MP:0001081 ! abnormal cranial ganglia morphology
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0003704
name: abnormal hair follicle development
def: "any anomaly in the development of the tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open" [GO:0001942]
is_a: MP:0000377 ! abnormal hair follicle morphology
is_a: MP:0020982 ! abnormal skin adnexa development

[Term]
id: MP:0003705
name: abnormal hypodermis morphology
def: "any structural anomaly of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia; usually consisting primarily of a fatty layer and may also include a muscle layer and/or a fibrous layer, or it may occur as a membranous layer only, being nearly devoid of fat; it contains skin ligaments extending between the dermis and deep fascia, cutaneous nerves, and superficial vessels, with terminal branches passing into the skin layers" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal hypoderm morphology" RELATED []
synonym: "abnormal stratum subcutaneum morphology" EXACT []
synonym: "abnormal subcutaneous tissue morphology" EXACT []
synonym: "abnormal subcutis morphology" EXACT []
synonym: "abnormal superficial fascia morphology" EXACT []
synonym: "abnormal tela subcutanea morphology" EXACT []
synonym: "hypodermal dysplasia" NARROW []
is_a: MP:0010678 ! abnormal skin adnexa morphology

[Term]
id: MP:0003706
name: abnormal cell nucleus count
def: "absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis" [MGI:pg]
synonym: "abnormal nucleus count" RELATED []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0003707
name: increased cell nucleus count
def: "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [MGI:pg]
synonym: "increased nucleus count" RELATED []
is_a: MP:0003706 ! abnormal cell nucleus count

[Term]
id: MP:0003708
name: binucleate
def: "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [MGI:pg]
is_a: MP:0003707 ! increased cell nucleus count

[Term]
id: MP:0003709
name: anucleate
def: "absent nucleus of a cell body when one is expected; often due to events leading to apoptosis" [MGI:pg]
synonym: "enucleate" EXACT []
is_a: MP:0003706 ! abnormal cell nucleus count

[Term]
id: MP:0003710
name: abnormal physiological neovascularization
def: "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process" [MESH:G09.330.582.751]
synonym: "abnormal angiogenesis involved in wound healing" EXACT []
synonym: "abnormal physiological angiogenesis" EXACT [MESH:G09.330.582.751]
xref: GO:0060055
is_a: MP:0000260 ! abnormal angiogenesis

[Term]
id: MP:0003711
name: pathological neovascularization
def: "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MESH:C23.550.589.500]
synonym: "pathologic angiogenesis" EXACT []
synonym: "pathologic neovascularization" EXACT []
synonym: "pathological angiogenesis" EXACT []
is_a: MP:0000249 ! abnormal blood vessel physiology

[Term]
id: MP:0003712
name: raised ear position
def: "outer ears which are situated above the normal location" [MGI:cwg, NCBI:matt]
is_a: MP:0000023 ! abnormal ear position

[Term]
id: MP:0003713
name: abnormal ear rotation
def: "outer ears that are positioned such that the ears are turned relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000023 ! abnormal ear position

[Term]
id: MP:0003714
name: absent platelets
def: "lack of non-nucleated cells found in the blood and involved in blood coagulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of platelets" EXACT []
synonym: "absent thrombocytes" EXACT []
is_a: MP:0003179 ! thrombocytopenia

[Term]
id: MP:0003715
name: posteriorly rotated ears
def: "outer ears that are positioned such that the ears are turned backwards relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0003713 ! abnormal ear rotation

[Term]
id: MP:0003716
name: anteriorly rotated ears
def: "outer ears that are positioned such that the ears are turned forward relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
synonym: "anteverted pinnae" EXACT []
is_a: MP:0003713 ! abnormal ear rotation

[Term]
id: MP:0003717
name: pallor
def: "an unnatural paleness to the skin, generally attributable to anemia" [MESH:C23.888.885.500]
subset: Europhenome_Terms
subset: IMPC_Prenatal
synonym: "pale skin" EXACT []
synonym: "pallid" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0003718
name: maternal effect
def: "expression of a phenotypic trait in a female animal's offspring that is dependent on the maternal genotype" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005384 ! cellular phenotype

[Term]
id: MP:0003719
name: abnormal pericyte morphology
def: "any structural anomaly of the connective tissue cells that occurs around capillaries or other small blood vessels" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal adventitial reticular cell morphology" EXACT []
synonym: "abnormal cell of Rouget morphology" EXACT []
synonym: "abnormal pericyte of Rouget morphology" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0003720
name: abnormal neural tube closure
def: "any anomaly in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline" [https://orcid.org/0009-0005-7755-8314]
subset: IMPC_Prenatal
synonym: "abnormal neural fold fusion" EXACT []
synonym: "abnormal neural tube fusion" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0003721
name: increased tumor growth/size
def: "greater than expected development of tumorous growth when compared to controls" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased neoplasm growth/size" BROAD []
synonym: "increased tumour growth/size" EXACT []
is_a: MP:0003448 ! abnormal tumor morphology

[Term]
id: MP:0003722
name: absent ureter
def: "missing the tube that conducts the urine from the renal pelvis to the bladder" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0003723
name: abnormal long bone morphology
def: "any structural anomaly of the bones that consist of a tubular shaft (diaphysis) and two ends that are wider than the shaft (epiphysis); long bones include the femora, tibiae, and fibulae, and the humeri, radii, and ulnae of the limbs; metacarpals and metatarsals of the autopods, the phalanges of the digits, and the clavicles" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "long bone dysplasia" NARROW []
is_a: MP:0009250 ! abnormal appendicular skeleton morphology

[Term]
id: MP:0003724
name: increased susceptibility to induced arthritis
def: "more likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [MGI:acv]
synonym: "decreased resistance to induced arthritis" EXACT []
is_a: MP:0002993 ! autoimmune arthritis
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0003725
name: increased autoantibody level
def: "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [https://orcid.org/0000-0003-3691-0324, MGI:acv]
is_a: MP:0001844 ! autoimmune response

[Term]
id: MP:0003726
name: decreased autoantibody level
def: "reduced level of antibodies to self-antigens present in the sera" [https://orcid.org/0000-0003-3691-0324, MGI:acv]
synonym: "reduced autoantibody level" EXACT []
is_a: MP:0001844 ! autoimmune response

[Term]
id: MP:0003727
name: abnormal retina layer morphology
def: "any structural anomaly of any of the layers that make up the retina" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal retinal layer morphology" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0003728
name: abnormal retina photoreceptor layer morphology
def: "any structural anomaly of the photoreceptor layer" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal photoreceptor layer" EXACT []
synonym: "abnormal retinal photoreceptor layer morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0003729
name: abnormal photoreceptor outer segment morphology
def: "any structural anomaly of the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal photoreceptor outer segments" EXACT []
xref: GO:0001750
is_a: MP:0001004 ! abnormal retina photoreceptor morphology

[Term]
id: MP:0003730
name: abnormal photoreceptor inner segment morphology
def: "any structural anomaly of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal photoreceptor inner segments" EXACT []
xref: GO:0001917
is_a: MP:0001004 ! abnormal retina photoreceptor morphology

[Term]
id: MP:0003731
name: abnormal retina outer nuclear layer morphology
def: "any structural anomaly of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal retina ONL morphology" EXACT []
synonym: "abnormal retinal ONL morphology" EXACT []
synonym: "abnormal retinal outer nuclear layer morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0003732
name: abnormal retina outer plexiform layer morphology
def: "any structural anomaly of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal retina OPL morphology" EXACT []
synonym: "abnormal retinal OPL morphology" EXACT []
synonym: "abnormal retinal outer plexiform layer morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0003733
name: abnormal retina inner nuclear layer morphology
def: "any structural anomaly of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal retinal INL morphology" EXACT []
synonym: "abnormal retinal inner nuclear layer morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0003734
name: abnormal retina inner plexiform layer morphology
def: "any structural anomaly of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal retina IPL morphology" EXACT []
synonym: "abnormal retinal inner plexiform layer morphology" EXACT []
synonym: "abnormal retinal IPL morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0003735
name: cup-shaped ears
def: "deeply concave appearance to the outer ear" [NCBI:matt]
is_a: MP:0000022 ! abnormal ear shape

[Term]
id: MP:0003736
name: folded helix
def: "the bending over of the upper cartilaginous rim of the outer ear" [NCBI:matt]
is_a: MP:0000022 ! abnormal ear shape

[Term]
id: MP:0003737
name: ossification of pinnae
def: "formation of bone in the outer ear, which is normally cartilaginous" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0003739
name: dense middle ear ossicles
def: "thickening of the three small bones of the middle ear" [NCBI:matt]
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0003740
name: fusion of middle ear ossicles
def: "union of the three small bones of the middle ear into a single structure" [NCBI:matt]
synonym: "fused middle ear ossicles" EXACT []
synonym: "middle ear ossicle fusion" EXACT []
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0003741
name: tinnitus
def: "persistent sensation of buzzing, ringing, clicking, or other noises in the ear" [MESH:C09.218.458.670, NCBI:matt]
is_a: MP:0001963 ! abnormal hearing physiology

[Term]
id: MP:0003742
name: narrow head
def: "a shorter ear- to -ear distance resulting in the appearance of a thin face and a protruding nasal region" [NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
synonym: "dolichocephaly" RELATED []
is_a: MP:0011495 ! abnormal head shape

[Term]
id: MP:0003743
name: abnormal facial morphology
def: "any structural anomaly of the face" [NCBI:matt]
subset: IMPC_Prenatal
is_a: MP:0000428 ! abnormal craniofacial morphology
is_a: MP:0000432 ! abnormal head morphology

[Term]
id: MP:0003744
name: obsolete abnormal orofacial morphology
def: "any structural anomaly of the the mouth and the face" [NCBI:matt]
is_obsolete: true
consider: MP:0003743

[Term]
id: MP:0003745
name: abnormal oral mucosa morphology
def: "any structural anomaly of the mucous membrane that lines the inside of the mouth and consists of stratified squamous epithelium termed oral epithelium and an underlying connective tissue termed lamina propria" [https://en.wikipedia.org/wiki/Oral_mucosa]
comment: In this context, oral mucosa includes any mucous membrane of the mouth - including palate, lips, uvula, etc.
synonym: "abnormal mouth mucosa morphology" EXACT []
synonym: "abnormal mucosal lining of the mouth" EXACT []
synonym: "abnormalities of the oral mucous membrane" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003746
name: stomatitis
def: "inflammation of the mucous lining of the mouth" [NCBI:matt]
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0003747
name: mouth mucosal ulcer
def: "lesions through the mucous membrane of the mouth, usually associated with loss of tissue" [NCBI:matt]
synonym: "mouth mucosal ulceration" EXACT []
is_a: MP:0003745 ! abnormal oral mucosa morphology

[Term]
id: MP:0003748
name: increased oral mucosa hemangioma incidence
def: "greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the oral mucosa, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
synonym: "increased oral mucosa haemangioma incidence" EXACT []
synonym: "oral mucosa haemangioma" RELATED []
synonym: "oral mucosa hemangioma" RELATED []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0003750 ! increased mouth tumor incidence
is_a: MP:0010292 ! increased alimentary system tumor incidence

[Term]
id: MP:0003749
name: down-turned corners of mouth
def: "the lateral points of the oral cavity opening appear in a lower position that the rest of the lips" [NCBI:matt]
synonym: "down slanted corners of mouth" EXACT []
synonym: "down turned corners of mouth" EXACT []
synonym: "down-slanted corners of mouth" EXACT []
is_a: MP:0031501 ! abnormal mouth shape

[Term]
id: MP:0003750
name: increased mouth tumor incidence
def: "greater than the expected number of neoplasms in the mouth tissues, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mouth tumour incidence" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology
is_a: MP:0008018 ! increased facial tumor incidence

[Term]
id: MP:0003751
name: oral leukoplakia
def: "white patchy lesions of the mucous membranes of the oral cavity; often considered a precancerous condition" [NCBI:matt]
synonym: "oral leucoplakia" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003745 ! abnormal oral mucosa morphology

[Term]
id: MP:0003752
name: increased oral papilloma incidence
def: "greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in the oral cavity" [MPATH:445]
synonym: "oral papilloma" RELATED []
is_a: MP:0002014 ! increased papilloma incidence
is_a: MP:0003750 ! increased mouth tumor incidence

[Term]
id: MP:0003753
name: increased lip papilloma incidence
def: "greater than the expected number of a benign epithelial tumor of the lip of the oral cavity, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "lip papilloma" RELATED []
is_a: MP:0003752 ! increased oral papilloma incidence
is_a: MP:0003780 ! increased lip tumor incidence

[Term]
id: MP:0003754
name: increased gingival papilloma incidence
def: "greater than the expected number of a benign epithelial tumor of the oral gum tissue" [NCBI:matt]
synonym: "gingival papilloma" RELATED []
is_a: MP:0003752 ! increased oral papilloma incidence

[Term]
id: MP:0003755
name: abnormal palate morphology
def: "any structural anomaly of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [NCBI:matt]
synonym: "palate dysplasia" NARROW []
is_a: MP:0000452 ! abnormal mouth morphology
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003756
name: abnormal hard palate morphology
def: "any structural anomaly of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult" [NCBI:matt]
is_a: MP:0013550 ! abnormal secondary palate morphology

[Term]
id: MP:0003757
name: high palate
def: "greater distance upward to the roof of the oral cavity than usual" [NCBI:matt]
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0003758
name: narrow palate
def: "abnormally slim shape to the roof of the oral cavity" [NCBI:matt]
synonym: "decreased palate width" EXACT []
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0003759
name: broad palate
def: "abnormally wide shape to the roof of the oral cavity" [NCBI:matt]
synonym: "increased palate width" EXACT []
synonym: "wide palate" EXACT []
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0003760
name: decreased palatal length
def: "reduction in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge" [NCBI:matt]
synonym: "reduced palatal length" EXACT []
synonym: "short palate" EXACT []
is_a: MP:0003764 ! abnormal palatal length

[Term]
id: MP:0003761
name: arched palate
def: "abnormally concaved shape to the roof of the oral cavity" [NCBI:matt]
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0003762
name: abnormal immune organ physiology
def: "any functional anomaly of the organs of the immune system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0003763
name: abnormal thymus physiology
def: "any functional anomaly of the primary lymphoid organ that is required for immune system development" [ISBN:0-683-40008-8]
is_a: MP:0001545 ! abnormal hematopoietic system physiology
is_a: MP:0003762 ! abnormal immune organ physiology
is_a: MP:0013561 ! abnormal endocrine gland physiology

[Term]
id: MP:0003764
name: abnormal palatal length
def: "any change in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge" [NCBI:matt]
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0003765
name: increased palatal length
def: "greater than average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge" [NCBI:matt]
synonym: "long palate" EXACT []
is_a: MP:0003764 ! abnormal palatal length

[Term]
id: MP:0003766
name: obsolete decreased palatal length
is_obsolete: true
replaced_by: MP:0003760

[Term]
id: MP:0003767
name: palate inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the palate" [NCBI:matt]
synonym: "palatal inflammation" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0003768
name: palatal telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the palate" [NCBI:matt]
synonym: "palatal telangiectases" EXACT []
synonym: "palatal telangiectasias" EXACT []
synonym: "palatal telangiectasis" EXACT []
is_a: MP:0003755 ! abnormal palate morphology
is_a: MP:0004175 ! telangiectasia

[Term]
id: MP:0003769
name: abnormal lip morphology
def: "any structural anomaly of the fleshy margins of the mouth" [NCBI:matt]
is_a: MP:0000452 ! abnormal mouth morphology

[Term]
id: MP:0003770
name: lip ulcer
def: "lesions through the mucous membrane of the inner surface of the lip" [NCBI:matt]
synonym: "lip ulceration" EXACT []
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003771
name: abnormal lip shape
def: "changes in the characteristic contours of the fleshy margins of the mouth" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003772
name: lip pit
def: "an abnormal hollow or depression in the fleshy margins of the mouth" [https://orcid.org/0000-0002-6490-7723, NCBI:matt, PMID:25201852]
comment: A lip pit is distinct from a cleft lip or a lip notch which may represent a mild case of cleft lip. {xref="PMID:37075751", xref="https://orcid.org/0000-0002-6490-7723"}
synonym: "lip pits" EXACT []
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003773
name: eclabion
def: "an outward turning of the inner surface of the lip" [NCBI:matt]
synonym: "eclabium" EXACT []
synonym: "eversion of a lip" EXACT []
synonym: "everted lip" EXACT []
synonym: "everted lips" EXACT []
synonym: "outward turned lip" EXACT []
synonym: "outward turned lips" EXACT []
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003774
name: thick lip
def: "lips having an abundance and often an excess of soft tissue" [NCBI:matt]
synonym: "fleshy lip" EXACT []
synonym: "full lip" EXACT []
synonym: "increased volume of lip" EXACT []
synonym: "plump lip" EXACT []
synonym: "prominent lip" EXACT []
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003775
name: thin lip
def: "lips having a reduced amount of soft tissue" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003776
name: lip atrophy
def: "acquired diminution of the size of the lip tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003777
name: lip inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the lips" [NCBI:matt]
synonym: "cheilitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0003778
name: lip telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the lip" [NCBI:matt]
synonym: "lip telangiectases" EXACT []
synonym: "lip telangiectasias" EXACT []
synonym: "lip telangiectasis" EXACT []
is_a: MP:0003769 ! abnormal lip morphology
is_a: MP:0004175 ! telangiectasia

[Term]
id: MP:0003779
name: lip cyst
def: "presence of one or more fluid-filled membranous sacs in one or both lips" [NCBI:matt]
synonym: "cystic lip" EXACT []
synonym: "cystic lips" EXACT []
synonym: "lip cysts" EXACT []
is_a: MP:0003769 ! abnormal lip morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0003780
name: increased lip tumor incidence
def: "greater than the expected number of abnormal rapidly proliferating cells in the lip, usually in the form of a distinct mass, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "increased lip tumour incidence" EXACT []
synonym: "lip tumor" RELATED []
synonym: "lip tumour" RELATED []
is_a: MP:0008018 ! increased facial tumor incidence

[Term]
id: MP:0003781
name: increased lip neuroma incidence
def: "greater than the expected number of a tumor derived from nerve cells or fibers residing in the lip, occurring in a specific population in a given time period" [NCBI:matt]
synonym: "lip neuroma" RELATED []
is_a: MP:0003780 ! increased lip tumor incidence
is_a: MP:0010281 ! increased nervous system tumor incidence

[Term]
id: MP:0003782
name: short lip
def: "lip that does not extend fully to the normal placement and meet the opposite lip" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003783
name: tented upper lip
def: "an upper lip having an inverted V- shape" [NCBI:matt]
is_a: MP:0012523 ! abnormal upper lip morphology

[Term]
id: MP:0003784
name: thin lip vermilion border
def: "reduced thickness of the line between the lip and the facial skin around the mouth" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003785
name: lip mucosal nodules
def: "small mass of tissue or aggregation of cells in the mucosal tissue of the inner lip" [NCBI:matt]
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0003786
name: premature aging
def: "earlier than normal occurrence of the normal signs of aging" [https://orcid.org/0000-0003-4606-0597]
synonym: "premature ageing" EXACT []
is_a: MP:0010768 ! mortality/aging

[Term]
id: MP:0003787
name: abnormal imprinting
def: "defects in the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself" [GO:0006349]
synonym: "abnormal regulation of gene expression by DNA imprinting" EXACT []
synonym: "abnormal regulation of gene expression by genetic imprinting" EXACT []
is_a: MP:0003121 ! genetic imprinting
is_a: MP:0012167 ! abnormal epigenetic regulation of gene expression

[Term]
id: MP:0003788
name: obsolete abnormal interferon physiology
def: "OBSOLETE. impairment or increase of the cellular release of any of the cytokines produced by T cells, fibroblasts and other cells in response to a challenge by a foreign agents such as viruses, bacteria, parasites and tumor cells" [ISBN:0-683-40008-8, MGI:hdene]
is_obsolete: true
consider: MP:0008555
consider: MP:0008750

[Term]
id: MP:0003789
name: increased osteosarcoma incidence
def: "greater than the expected number of a malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes, occurring in a specific population in a given time period; osteosarcoma is a highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone" [MPATH:397]
synonym: "osteogenic sarcoma" RELATED []
is_a: MP:0002032 ! increased sarcoma incidence
is_a: MP:0010280 ! increased skeletal tumor incidence

[Term]
id: MP:0003790
name: absent CD4-positive, alpha-beta T cells
def: "lack of the set of single-positive T cells that express CD4 on their surface" [https://orcid.org/0000-0003-3691-0324, MGI:acv, MGI:cwg]
synonym: "absent CD4+ T cells" EXACT []
synonym: "absent CD4+8- T cells" EXACT []
synonym: "absent CD4-positive T cells" EXACT []
synonym: "absent single positive T cells" BROAD []
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number

[Term]
id: MP:0003791
name: abnormal minor salivary gland morphology
def: "any structural anomaly of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0003792
name: abnormal major salivary gland morphology
def: "any structural anomaly of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0003793
name: abnormal submandibular gland morphology
def: "any structural anomaly of either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal maxillary gland morphology" EXACT []
synonym: "abnormal submaxillary gland morphology" EXACT []
is_a: MP:0003792 ! abnormal major salivary gland morphology

[Term]
id: MP:0003794
name: delayed somite formation
def: "late onset of the induction and/or differentiation of the somites" [https://orcid.org/0000-0003-4606-0597, J:99723]
is_a: MP:0001688 ! abnormal somite development

[Term]
id: MP:0003795
name: abnormal bone structure
def: "anomaly in the composite material or the layered arrangement of the bony endoskeleton of the body" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0003797
name: abnormal compact bone morphology
alt_id: MP:0003796
def: "any structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [ISBN:0-683-40008-8, MGI:hdene]
synonym: "abnormal cortical bone morphology" EXACT []
synonym: "abnormal dense bone" EXACT []
synonym: "abnormal lamellar bone" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0003798
name: abnormal Harderian gland pigmentation
def: "any anomaly in the coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid, due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:llw2]
comment: The Harderian gland does not normally exist in some types of mammals (bats, cows and horses), terrestrial carnivores, and higher primates including human.
is_a: MP:0005248 ! abnormal Harderian gland morphology
is_a: MP:0009389 ! abnormal extracutaneous pigmentation

[Term]
id: MP:0003799
name: impaired macrophage chemotaxis
alt_id: MP:0005496
def: "reduced diffusion or accumulation of macrophages in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [GO:0048246]
synonym: "decreased macrophage recruitment" EXACT []
synonym: "impaired macrophage migration" EXACT []
synonym: "impaired macrophage recruitment" EXACT []
synonym: "reduced macrophage recruitment" EXACT []
is_a: MP:0010760 ! abnormal macrophage chemotaxis

[Term]
id: MP:0003800
name: monodactyly
def: "having only one toe or digit on each extremity" [https://orcid.org/0009-0005-7755-8314]
synonym: "monodactylous" EXACT []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0003801
name: obsolete deviant histocompatibility locus
def: "OBSOLETE. deviation from the parental type of histocompatibility" [MGI:mberry]
synonym: "altered histocompatibility locus" EXACT []
is_obsolete: true

[Term]
id: MP:0003802
name: obsolete deviant class I histocompatibility locus
def: "OBSOLETE. deviation from the parental type of class I histocompatibility" [MGI:mberry]
is_obsolete: true

[Term]
id: MP:0003803
name: obsolete deviant class II histocompatibility locus
def: "OBSOLETE. deviation from the parental type of class II histocompatibility" [MGI:mberry]
is_obsolete: true

[Term]
id: MP:0003804
name: obsolete deviant minor histocompatibility locus
def: "OBSOLETE. deviation from the parental type of minor histocompatibility" [MGI:mberry]
is_obsolete: true

[Term]
id: MP:0003805
name: obsolete deviant histocompatibility-related locus
def: "OBSOLETE. deviation from the parental type of a histocompatibility-related locus" [MGI:mberry]
is_obsolete: true

[Term]
id: MP:0003806
name: abnormal nucleotide metabolism
def: "any anomaly in the chemical reactions and pathways involving a nucleotide, including metabolic, catabolic and biosynthetic processes" [GO:0009117]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0003807
name: camptodactyly
def: "permanent flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [https://orcid.org/0000-0003-3691-0324]
synonym: "flexed digits" EXACT []
synonym: "flexed fingers" NARROW []
synonym: "flexed toes" NARROW []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0003808
name: increased atrioventricular cushion size
def: "larger than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal" [MGI:mac]
synonym: "enlarged atrioventricular cushions" EXACT []
synonym: "enlarged endocardial cushions" EXACT []
synonym: "increased endocardial cushion size" EXACT []
is_a: MP:0000297 ! abnormal atrioventricular cushion morphology

[Term]
id: MP:0003809
name: abnormal hair shaft morphology
alt_id: MP:0002854
def: "any structural anomaly of the cuticle, cortex and/or medulla of a hair" [MGI:llw2]
synonym: "abnormal hair fiber morphology" EXACT []
synonym: "abnormal hair fibre morphology" EXACT []
synonym: "abnormal hair shaft" BROAD []
synonym: "hair shaft dysplasia" NARROW []
is_a: MP:0000367 ! abnormal coat/ hair morphology
is_a: MP:0030572 ! abnormal pilosebaceous unit morphology

[Term]
id: MP:0003810
name: abnormal hair cuticle
def: "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [MGI:llw2]
is_a: MP:0003809 ! abnormal hair shaft morphology

[Term]
id: MP:0003811
name: abnormal hair cortex morphology
def: "any structural anomaly in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix" [MGI:llw2]
is_a: MP:0003809 ! abnormal hair shaft morphology

[Term]
id: MP:0003812
name: abnormal hair medulla
def: "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0003809 ! abnormal hair shaft morphology

[Term]
id: MP:0003813
name: abnormal hair follicle dermal papilla morphology
def: "any structural anomaly of the mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts" [PMID:19211055]
is_a: MP:0010681 ! abnormal hair follicle bulb morphology

[Term]
id: MP:0003814
name: vascular smooth muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the vascular smooth muscle, typically resulting in decreased size" [MGI:cwg]
synonym: "hypoplastic vascular smooth muscle" EXACT []
synonym: "vascular smooth muscle cell hypoplasia" EXACT []
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology

[Term]
id: MP:0003815
name: hairless
def: "having no hair at any time throughout lifespan, generally referring to primary genetic hairlessness" [MGI:llw2]
synonym: "absent hair" BROAD []
synonym: "bald" RELATED []
synonym: "hypotrichosis" RELATED []
synonym: "naked" RELATED []
synonym: "nude" EXACT []
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0003816
name: abnormal pituitary gland development
def: "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [https://orcid.org/0000-0003-4606-0597, J:51160]
synonym: "abnormal pituitary development" RELATED []
is_a: MP:0000633 ! abnormal pituitary gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0003817
name: abnormal pituitary diverticulum morphology
def: "any structural anomaly of a tubular outgrowth of ectoderm from the stomodeum of the embryo; the outgrowth grows toward the infundibular process of the diencephalon, around which it forms a cup-like mass, giving rise to the pars distalis and pars juxtaneuralis of the hypophysis" [ISBN:0-683-40008-8]
synonym: "abnormal craniopharyngeal duct morphology" EXACT []
synonym: "abnormal hypophyseal pouch morphology" EXACT []
synonym: "abnormal Rathke diverticulum morphology" EXACT []
synonym: "abnormal Rathke's pocket morphology" EXACT []
synonym: "abnormal Rathke's pouch morphology" EXACT []
is_a: MP:0013337 ! abnormal adenohypophysis development

[Term]
id: MP:0003818
name: abnormal eye muscle development
def: "malformation or arrest of differentiation of the muscles of the eye" [https://orcid.org/0000-0003-4606-0597, J:51160]
is_a: MP:0000733 ! abnormal muscle development
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0003819
name: increased left ventricle diastolic pressure
def: "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:cur]
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003820
name: increased left ventricle systolic pressure
def: "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:cur]
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003821
name: decreased left ventricle diastolic pressure
def: "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:cur]
synonym: "reduced left ventricle diastolic pressure" EXACT []
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003822
name: decreased left ventricle systolic pressure
def: "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:cur]
synonym: "reduced left ventricle systolic pressure" EXACT []
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003823
name: increased left ventricle developed pressure
def: "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:cur]
synonym: "increased left ventricular developed pressure" EXACT []
synonym: "increased LVDP" EXACT []
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003824
name: decreased left ventricle developed pressure
def: "decrease in the difference between left ventricular systolic and diastolic pressures" [RGD:cur]
synonym: "decreased left ventricular developed pressure" EXACT []
synonym: "decreased LVDP" EXACT []
synonym: "reduced left ventricular developed pressure" EXACT []
synonym: "reduced LVDP" EXACT []
is_a: MP:0010754 ! abnormal heart left ventricle pressure

[Term]
id: MP:0003825
name: abnormal pillar cell morphology
def: "any structural anomaly of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology

[Term]
id: MP:0003826
name: abnormal Mullerian duct morphology
def: "any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal Muller duct morphology" EXACT []
synonym: "abnormal paramesonephric duct" EXACT []
is_a: MP:0008487 ! abnormal mesonephros morphology

[Term]
id: MP:0003827
name: abnormal Wolffian duct morphology
def: "any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [ISBN:0-683-40008-8, MESH:A16.254.940]
synonym: "abnormal archinephric duct morphology" EXACT []
synonym: "abnormal ductus mesonephricus" EXACT []
synonym: "abnormal Gartner's duct morphology" EXACT []
synonym: "abnormal Leydig's duct morphology" EXACT []
synonym: "abnormal mesonephric duct morphology" EXACT []
synonym: "abnormal nephric duct morphology" EXACT []
synonym: "abnormal pronephric duct morphology" EXACT []
is_a: MP:0008487 ! abnormal mesonephros morphology

[Term]
id: MP:0003828
name: pulmonary edema
def: "an accumulation of an excessive amount of serous fluid in the parenchyma and the alveoli via effusion of intravascular fluid from the pulmonary vascular bed" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, MESH:C08.381.742]
synonym: "pulmonary oedema" EXACT []
synonym: "wet lung" EXACT [MESH:C08.381.742]
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0001785 ! edema

[Term]
id: MP:0003829
name: impaired febrile response
def: "reduced or absent febrile response to exogenous or endogenous pyrogens" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired fever response" EXACT []
is_a: MP:0001777 ! abnormal body temperature homeostasis

[Term]
id: MP:0003830
name: abnormal testis development
def: "abnormal morphogenesis of the male reproductive gland containing the germ cells" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001146 ! abnormal testis morphology
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0003833
name: decreased satellite cell number
def: "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased number of satellite cells" EXACT []
synonym: "reduced satellite cell number" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0003834
name: abnormal adrenergic chromaffin cell morphology
def: "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal adrenergic chromaffin neuron" EXACT []
is_a: MP:0008504 ! abnormal adrenal chromaffin cell morphology

[Term]
id: MP:0003838
name: abnormal milk ejection
def: "anomaly of the milk ejection reflex in response to suckling during lactation" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001882 ! abnormal lactation
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0003839
name: abnormal insulin clearance
def: "increase or decrease in the rate at which insulin is removed from the blood stream" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0003840
name: abnormal coronal suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones and the frontal bone" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal frontoparietal suture morphology" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0003841
name: abnormal lambdoid suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the superior border of the occipital bone and the posterior borders of the right and left parietal bones" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal lambdoidal suture morphology" EXACT []
synonym: "abnormal occipital suture morphology" EXACT []
synonym: "abnormal occipitoparietal suture morphology" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0003842
name: abnormal metopic suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the frontal bones from the sagittal suture to the root of the nose; it is visible in neonates and juveniles, but it is frequently obliterated in some adult organisms; in mice and rats, the posterior frontal (PF) suture, situated between the frontal bones, is analogous to the human metopic suture; the anterior landmark for the PF suture is the jugum limitans; the posterior landmark for the PF suture is the bregma" [https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/metopic-suture, ISBN:0803606559, PMID:15882577]
synonym: "abnormal frontal suture morphology" EXACT []
synonym: "abnormal interfrontal suture morphology" EXACT []
synonym: "abnormal median frontal suture morphology" EXACT []
synonym: "abnormal mediofrontal suture morphology" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0003843
name: abnormal sagittal suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal interparietal suture morphology" EXACT []
synonym: "abnormal longitudinal suture morphology" EXACT []
synonym: "abnormal parietal suture morphology" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0003844
name: abnormal squamoparietal suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the squamous part of the temporal bone and the inferior aspect of the parietal bone; posteriorly, the squamous suture becomes the parietomastoid suture where the mastoid process articulates with the parietal bone; anteriorly, the squamous suture extends towards the pterion" [http://anatomyzone.com/anatomy-feed/squamous-suture/, https://orcid.org/0000-0002-6490-7723, ISBN:0803606559]
synonym: "abnormal squamo-parietal suture morphology" EXACT []
synonym: "abnormal squamosal suture morphology" EXACT []
synonym: "abnormal squamous suture morphology" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology

[Term]
id: MP:0003845
name: abnormal decidualization
def: "atypical cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation; this process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta; expected changes include the eosinophilic proliferation around arterioles after ovulation or progesterone action on endometrium which increases glandular epithelial secretion, stimulates glycogen accumulation in stromal cell cytoplasm, and promotes stromal vascularity (spiral arterioles) and edema" [GO:0046697, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal decidual cell reaction" EXACT []
synonym: "defective decidualization" EXACT []
is_a: MP:0001712 ! abnormal placenta development
is_a: MP:0004014 ! abnormal uterine environment

[Term]
id: MP:0003846
name: matted coat
def: "coat hairs sticks together to form clumps and does not lie flat" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002074 ! abnormal hair texture

[Term]
id: MP:0003847
name: disorganized lens bow
def: "derangement of the area where the lens epithelium pushes into the lens proper and forms new lens fibers" [MGI:brs]
synonym: "disorganised lens bow" EXACT []
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0003848
name: brittle hair
def: "hair is susceptible to breakage" [MGI:llw2]
is_a: MP:0002074 ! abnormal hair texture

[Term]
id: MP:0003849
name: greasy coat
def: "fur is oily in appearance or texture" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "oily coat" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0003850
name: abnormal thymocyte activation
def: "anomaly in the process of producing activated thymocytes from naive thymocytes" [MGI:mberry]
is_a: MP:0001828 ! abnormal T cell activation
is_a: MP:0003763 ! abnormal thymus physiology

[Term]
id: MP:0003851
name: skeletal muscle interstitial fibrosis
def: "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8]
is_a: MP:0009419 ! skeletal muscle fibrosis

[Term]
id: MP:0003852
name: skeletal muscle necrosis
def: "morphological changes resulting from pathological death of skeletal muscle tissue; usually due to irreversible damage" [ISBN:0-683-40008-8]
synonym: "necrotic skeletal muscle" EXACT []
synonym: "necrotic skeletal muscles" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0003853
name: dry skin
def: "skin characterized by the lack of natural or normal moisture" [https://orcid.org/0009-0005-7755-8314]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "xerosis" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0003854
name: abnormal forelimb stylopod morphology
def: "any structural anomaly of the proximal element of the forelimb including the humerus" [https://orcid.org/0000-0003-3691-0324, PMID:12560810]
is_a: MP:0000550 ! abnormal forelimb morphology

[Term]
id: MP:0003855
name: abnormal forelimb zeugopod morphology
def: "any structural anomaly of the distal elements of the forelimb including the radius and ulna" [https://orcid.org/0000-0003-3691-0324, PMID:12560810]
synonym: "abnormal lower arm morphology" RELATED []
is_a: MP:0000550 ! abnormal forelimb morphology

[Term]
id: MP:0003856
name: abnormal hindlimb stylopod morphology
def: "any structural anomaly of the proximal element of the hindlimb including the femur" [https://orcid.org/0000-0003-3691-0324, PMID:12560810]
synonym: "abnormal hind limb stylopod morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology

[Term]
id: MP:0003857
name: abnormal hindlimb zeugopod morphology
def: "any structural anomaly of the distal elements of the hindlimb including the tibia and fibula" [https://orcid.org/0000-0003-3691-0324, PMID:12560810]
synonym: "abnormal hind limb zeugopod morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology

[Term]
id: MP:0003858
name: enhanced coordination
def: "improved ability to execute integrated movements of muscle" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0003859
name: abnormal Harderian gland physiology
def: "any functional anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents)" [https://orcid.org/0009-0005-7755-8314, ISBN:0486631850, PMID:8843648]
comment: The Harderian gland does not normally exist in some types of mammals (bats, cows and horses), terrestrial carnivores, and higher primates including human.
is_a: MP:0013557 ! abnormal merocrine gland physiology

[Term]
id: MP:0003860
name: abnormal carbon dioxide level
def: "anomalous concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0003861
name: abnormal nervous system development
def: "impaired or altered growth of the components of the nervous system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0003862
name: decreased aggression towards male mice
def: "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice" [https://orcid.org/0009-0005-7755-8314]
synonym: "reduced aggression towards males" EXACT []
is_a: MP:0003863 ! decreased aggression towards mice

[Term]
id: MP:0003863
name: decreased aggression towards mice
def: "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [https://orcid.org/0009-0005-7755-8314]
synonym: "reduced aggression towards mice" EXACT []
is_a: MP:0005656 ! decreased aggression
is_a: MP:0021115 ! abnormal aggression towards conspecific

[Term]
id: MP:0003864
name: abnormal midbrain development
def: "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal mesencephalon development" EXACT []
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0003865
name: lymph node inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [https://orcid.org/0009-0005-7755-8314]
synonym: "lymphadenitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003762 ! abnormal immune organ physiology

[Term]
id: MP:0003866
name: abnormal defecation
def: "anomaly in the discharge of feces from the body" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal defaecation" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology

[Term]
id: MP:0003867
name: increased defecation amount
def: "increase in the amount of discharge of feces from the body" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased defaecation amount" EXACT []
is_a: MP:0020147 ! abnormal defecation amount

[Term]
id: MP:0003868
name: abnormal feces composition
def: "increase or decrease in the amount of compounds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal faeces composition" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0003869
name: ectopic cartilage
def: "positional abnormality of cartilage" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0003870
name: decreased urine glucose level
def: "a reduced amount of glucose in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "reduced urine glucose level" EXACT []
is_a: MP:0001758 ! abnormal urine glucose level

[Term]
id: MP:0003871
name: abnormal myelin sheath morphology
def: "any structural anomaly of the insulating envelope that surrounds nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005404 ! abnormal axon morphology

[Term]
id: MP:0003872
name: absent heart right ventricle
def: "missing the lower right chamber of the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent pulmonary ventricle" EXACT []
synonym: "absent right ventricle" EXACT []
is_a: MP:0003920 ! abnormal heart right ventricle morphology

[Term]
id: MP:0003873
name: pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pharyngeal arches, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "branchial arch hypoplasia" EXACT []
synonym: "decreased branchial arch cellularity" RELATED []
synonym: "hypoplastic branchial arches" EXACT []
is_a: MP:0006346 ! small pharyngeal arch

[Term]
id: MP:0003874
name: absent pharyngeal arches
def: "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "absent branchial arches" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0003875
name: abnormal hair follicle regression
def: "abnormal length of time for the onset of catagen phase of the cyclic transformation of the hair follicle" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0003876
name: obsolete abnormal cerebral function
def: "OBSOLETE. anomalous activity of the thin layer of grey matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri that is responsible for higher mental functions" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0003877
name: abnormal serotonergic neuron morphology
def: "any structural anomaly of the neurons that secrete serotonin" [https://orcid.org/0000-0002-6490-7723, J:54240]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0003878
name: abnormal ear physiology
def: "any functional anomaly of the ear, not due to an anatomical defect" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005377 ! hearing/vestibular/ear phenotype

[Term]
id: MP:0003879
name: abnormal hair cell physiology
def: "any functional anomaly of the sensory epithelial cells of the inner ear" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003878 ! abnormal ear physiology
is_a: MP:0010055 ! abnormal sensory neuron physiology

[Term]
id: MP:0003880
name: abnormal central pattern generator function
def: "any functional anomaly of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [https://orcid.org/0000-0003-4606-0597, PMID:14766172]
synonym: "abnormal CPG function" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0003881
name: abnormal nephron morphology
def: "any structural anomaly of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003882
name: abnormal pulse pressure
def: "anomaly in the difference between systolic and diastolic blood pressure" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0000230 ! abnormal systemic arterial blood pressure

[Term]
id: MP:0003883
name: enlarged stomach
def: "increased size of the stomach" [https://orcid.org/0009-0005-7755-8314]
synonym: "increased stomach size" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0003884
name: decreased macrophage cell number
def: "fewer than the normal numbers of macrophages" [MGI:acv]
synonym: "decreased macrophage count" EXACT []
synonym: "reduced macrophage cell number" EXACT []
synonym: "reduced macrophage count" EXACT []
is_a: MP:0000221 ! decreased leukocyte cell number
is_a: MP:0020202 ! abnormal macrophage cell number

[Term]
id: MP:0003885
name: abnormal rostral-caudal body axis extension
def: "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [MGI:brs]
synonym: "abnormal rostro-caudal body axis extension" EXACT []
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0003886
name: abnormal embryonic epiblast morphology
def: "any structural anomaly of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion" [http://discovery.lifemapsc.com/in-vivo-development/epiblast/epiblast, PMID:21123814]
comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
synonym: "abnormal ectoblast morphology" EXACT []
synonym: "abnormal embryonic ectoderm morphology" EXACT []
synonym: "abnormal EPI" EXACT []
synonym: "abnormal primary ectoderm morphology" EXACT []
synonym: "abnormal primitive ectoderm morphology" EXACT []
is_a: MP:0012103 ! abnormal bilaminar embryonic disk morphology

[Term]
id: MP:0003887
name: increased hepatocyte apoptosis
def: "increase in the number of hepatocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0010080 ! abnormal hepatocyte physiology

[Term]
id: MP:0003888
name: liver hemorrhage
def: "bleeding within the liver" [https://orcid.org/0000-0002-6490-7723]
synonym: "hepatic haemorrhage" EXACT []
synonym: "hepatic hemorrhage" EXACT []
synonym: "liver haemorrhage" EXACT []
is_a: MP:0000609 ! abnormal liver physiology
is_a: MP:0001634 ! internal hemorrhage

[Term]
id: MP:0003889
name: enhanced sensorimotor gating
def: "amplification of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0002634 ! abnormal sensorimotor gating

[Term]
id: MP:0003890
name: abnormal embryonic-extraembryonic boundary morphology
def: "any structural anomaly in the delineating tissue and the segregation between the embryo proper and extraembryonic tissues" [MGI:brs]
is_a: MP:0014134 ! abnormal embryo morphology

[Term]
id: MP:0003891
name: increased allantois apoptosis
def: "increase in the number of cells of the allantois undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0003892
name: abnormal gastric gland morphology
def: "any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal fundic glands" EXACT []
synonym: "abnormal fundus gland" EXACT []
synonym: "abnormal gastric follicle" EXACT []
synonym: "abnormal oxyntic gland morphology" EXACT []
synonym: "abnormal Wassmann gland morphology" EXACT []
is_a: MP:0010792 ! abnormal stomach mucosa morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0003893
name: increased hepatocyte proliferation
def: "increase in the expansion rate of the hepatocyte cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0010080 ! abnormal hepatocyte physiology

[Term]
id: MP:0003894
name: abnormal Purkinje cell innervation
def: "any structural anomaly of the supply of nerve fibers that connect to the Purkinje cells" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0003895
name: increased ectoderm apoptosis
def: "increase in the number of ectoderm cells undergoing programmed cell death during development" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001675 ! abnormal ectoderm development
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis

[Term]
id: MP:0003896
name: prolonged PR interval
def: "increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [https://orcid.org/0009-0005-7755-8314]
synonym: "prolonged PR-interval" EXACT []
is_a: MP:0003901 ! abnormal PR interval
is_a: MP:0010519 ! atrioventricular block

[Term]
id: MP:0003897
name: abnormal ST segment
def: "anomaly in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal ST segment duration" EXACT []
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature

[Term]
id: MP:0003898
name: abnormal QRS complex
def: "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction" [https://orcid.org/0009-0005-7755-8314]
comment: The ventricles have a large muscle mass compared to the atria and so the QRS complex usually has a much larger amplitude than the P-wave.
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature

[Term]
id: MP:0003899
name: abnormal QT interval
def: "anomaly in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave" [https://orcid.org/0000-0003-4606-0597, PMID:12114851]
comment: A prolonged QT interval is a risk factor for ventricular tachyarrhythmias and sudden death. It varies with heart rate and for clinical relevance requires a correction for this, giving the QTc.
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature

[Term]
id: MP:0003900
name: shortened QT interval
def: "decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave" [https://orcid.org/0000-0003-4606-0597, PMID:12114851]
synonym: "decreased QT interval" EXACT []
synonym: "reduced QT interval" EXACT []
synonym: "short QT" EXACT []
synonym: "short QT syndrome" RELATED []
is_a: MP:0003899 ! abnormal QT interval

[Term]
id: MP:0003901
name: abnormal PR interval
def: "anomaly in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [https://orcid.org/0009-0005-7755-8314]
comment: The PR interval is measured from the beginning of the P wave to the beginning of the QRS complex. The PR interval reflects the time the electrical impulse takes to travel from the sinus node through the AV node and entering the ventricles. The PR interval is therefore a good estimate of AV node function.
is_a: MP:0006141 ! abnormal atrioventricular node conduction
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature

[Term]
id: MP:0003902
name: abnormal cell mass
def: "anomaly in the total physical bulk or volume of a cell compared to the normal state" [RGD:cur]
is_a: MP:0000358 ! abnormal cell morphology

[Term]
id: MP:0003903
name: increased cell mass
def: "greater total physical bulk or volume of a cell compared to the normal state" [RGD:cur]
is_a: MP:0003902 ! abnormal cell mass

[Term]
id: MP:0003904
name: decreased cell mass
def: "reduction in the total physical bulk or volume of a cell compared to the normal state" [RGD:cur]
synonym: "reduced cell mass" EXACT []
is_a: MP:0003902 ! abnormal cell mass

[Term]
id: MP:0003905
name: abnormal aorta elastin content
def: "anomaly in the physical amount of elastin in the aorta compared to the normal state" [RGD:cur]
is_a: MP:0003211 ! abnormal aorta elastic fiber morphology

[Term]
id: MP:0003906
name: increased aorta elastin content
def: "greater physical amount of elastin in the aorta compared to the normal state" [RGD:cur]
is_a: MP:0003905 ! abnormal aorta elastin content

[Term]
id: MP:0003907
name: decreased aorta elastin content
def: "reduction in the physical amount of elastin in the aorta compared to the normal state" [RGD:cur]
synonym: "reduced aorta elastin content" EXACT []
is_a: MP:0003905 ! abnormal aorta elastin content

[Term]
id: MP:0003908
name: decreased stereotypic behavior
def: "less frequent incidence of repetitive, invariant, persistent motor patterns that do not appear to be purposeful" [RGD:cur]
synonym: "decreased stereotypic behaviour" EXACT []
synonym: "reduced stereotypic behavior" EXACT []
synonym: "reduced stereotypic behaviour" EXACT []
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0003913
name: increased heart right ventricle weight
def: "greater than average weight of the right ventricle compared to the average" [RGD:cur]
synonym: "increased right ventricle weight" EXACT []
is_a: MP:0010563 ! increased heart right ventricle size
is_a: MP:0020205 ! abnormal heart right ventricle weight

[Term]
id: MP:0003914
name: decreased heart right ventricle weight
def: "less than average weight of the right ventricle compared to the average" [RGD:cur]
synonym: "decreased right ventricle weight" EXACT []
synonym: "reduced right ventricle weight" EXACT []
is_a: MP:0003649 ! decreased heart right ventricle size
is_a: MP:0020205 ! abnormal heart right ventricle weight

[Term]
id: MP:0003915
name: increased heart left ventricle weight
def: "greater than average weight of the heart left ventricle compared to the average for a particular population" [RGD:cur]
synonym: "increased left ventricle weight" EXACT []
is_a: MP:0010579 ! increased heart left ventricle size
is_a: MP:0020204 ! abnormal heart left ventricle weight

[Term]
id: MP:0003916
name: decreased heart left ventricle weight
def: "less than average weight of the heart left ventricle compared to the average for a particular population" [RGD:cur]
synonym: "decreased left ventricle weight" EXACT []
synonym: "reduced left ventricle weight" EXACT []
is_a: MP:0010580 ! decreased heart left ventricle size
is_a: MP:0020204 ! abnormal heart left ventricle weight

[Term]
id: MP:0003917
name: increased kidney weight
def: "greater weight of the organs responsible for urine secretion" [RGD:cur]
is_a: MP:0002707 ! abnormal kidney weight
is_a: MP:0003068 ! enlarged kidney

[Term]
id: MP:0003918
name: decreased kidney weight
def: "reduced weight of the organs responsible for urine secretion" [RGD:cur]
synonym: "reduced kidney weight" EXACT []
is_a: MP:0002707 ! abnormal kidney weight
is_a: MP:0002989 ! small kidney

[Term]
id: MP:0003919
name: obsolete abnormal lymph node cellularity
def: "OBSOLETE. anomaly in the cellular make up of the lymph nodes" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true

[Term]
id: MP:0003920
name: abnormal heart right ventricle morphology
def: "any structural anomaly of the right lower chamber of the heart" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "abnormal right ventricle morphology" EXACT []
synonym: "abnormal RV" EXACT []
synonym: "RV abnormality" RELATED []
xref: Fyler:1820
is_a: MP:0005294 ! abnormal heart ventricle morphology

[Term]
id: MP:0003921
name: abnormal heart left ventricle morphology
def: "any structural anomaly of the left lower chamber of the heart" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "abnormal left ventricle morphology" EXACT []
synonym: "abnormal LV" EXACT []
synonym: "LV abnormality" EXACT []
xref: Fyler:1810
is_a: MP:0005294 ! abnormal heart ventricle morphology

[Term]
id: MP:0003922
name: abnormal heart right atrium morphology
def: "any structural anomaly of the right upper chamber of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal right atrium morphology" EXACT []
xref: Fyler:1770
is_a: MP:0003105 ! abnormal heart atrium morphology

[Term]
id: MP:0003923
name: abnormal heart left atrium morphology
def: "any structural anomaly of the left upper chamber of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal left atrium morphology" EXACT []
xref: Fyler:3010
is_a: MP:0003105 ! abnormal heart atrium morphology

[Term]
id: MP:0003924
name: diaphragmatic hernia
def: "protrusion of abdominal contents into the thoracic cavity through a hole in the diaphragm" [https://orcid.org/0000-0003-4606-0597]
synonym: "congenital diaphragmatic hernia" NARROW []
synonym: "herniated diaphragm" EXACT []
is_a: MP:0002279 ! abnormal diaphragm morphology

[Term]
id: MP:0003925
name: abnormal cellular glucose uptake
def: "anomaly in the ability of a cell to take in glucose from the environment" [RGD:cur]
synonym: "abnormal cellular glucose import" EXACT []
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0003926
name: decreased cellular glucose uptake
def: "reduced ability of a cell to take in glucose from the environment" [RGD:cur]
synonym: "impaired cellular glucose import" EXACT []
synonym: "impaired cellular glucose uptake" EXACT []
is_a: MP:0003925 ! abnormal cellular glucose uptake

[Term]
id: MP:0003927
name: increased cellular glucose import
def: "increased ability of a cell to take in glucose from the environment" [RGD:cur]
synonym: "enhanced cellular glucose import" EXACT []
synonym: "improved cellular glucose uptake" EXACT []
is_a: MP:0003925 ! abnormal cellular glucose uptake

[Term]
id: MP:0003928
name: increased heart rate variability
def: "increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle" [RGD:cur]
comment: Heart rate variability (HRV) is the variation of beat-to-beat intervals. A healthy heart has a large HRV, while decreased or absent variability may indicate cardiac disease. HRV also decreases with exercise-induced tachycardia. Heart rate variability (HRV) refers to the beat-to-beat alterations in heart rate. Under resting conditions, the ECG of healthy individuals exhibits periodic variation in R-R intervals. This rhythmic phenomenon, known as respiratory sinus arrhythmia (RSA), fluctuates with the phase of respiration -- cardio-acceleration during inspiration, and cardio-deceleration during expiration. RSA is predominantly mediated by respiratory gating of parasympathetic efferent activity to the heart: vagal efferent traffic to the sinus node occurs primarily in phase with expiration and is absent or attenuated during inspiration. The major reason for the interest in measuring HRV stems from its ability to predict survival after heart attack. Over half a dozen prospective studies have shown that reduced HRV predicts sudden death in patients with MI, independent of other prognostic indicators such as ejection fraction. Reduced HRV appears to be a marker of fatal ventricular arrhythmia. Moreover, a small number of studies have begun to suggest that reduced HRV may predict risk of survival even among individuals free of CHD.
synonym: "increased heart rate variation" EXACT []
synonym: "increased HRV" EXACT []
synonym: "increased respiratory sinus arrhythmia" EXACT []
is_a: MP:0004122 ! abnormal sinus arrhythmia

[Term]
id: MP:0003929
name: decreased heart rate variability
def: "reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle" [RGD:cur]
comment: Heart rate variability (HRV) is the variation of beat-to-beat intervals. A healthy heart has a large HRV, while decreased or absent variability may indicate cardiac disease. HRV also decreases with exercise-induced tachycardia. Heart rate variability (HRV) refers to the beat-to-beat alterations in heart rate. Under resting conditions, the ECG of healthy individuals exhibits periodic variation in R-R intervals. This rhythmic phenomenon, known as respiratory sinus arrhythmia (RSA), fluctuates with the phase of respiration -- cardio-acceleration during inspiration, and cardio-deceleration during expiration. RSA is predominantly mediated by respiratory gating of parasympathetic efferent activity to the heart: vagal efferent traffic to the sinus node occurs primarily in phase with expiration and is absent or attenuated during inspiration. The major reason for the interest in measuring HRV stems from its ability to predict survival after heart attack. Over half a dozen prospective studies have shown that reduced HRV predicts sudden death in patients with MI, independent of other prognostic indicators such as ejection fraction. Reduced HRV appears to be a marker of fatal ventricular arrhythmia. Moreover, a small number of studies have begun to suggest that reduced HRV may predict risk of survival even among individuals free of CHD.
synonym: "decreased heart rate variation" EXACT []
synonym: "decreased HRV" EXACT []
synonym: "decreased respiratory sinus arrhythmia" EXACT []
synonym: "reduced heart rate variability" RELATED []
synonym: "reduced heart rate variation" EXACT []
synonym: "reduced HRV" EXACT []
is_a: MP:0004122 ! abnormal sinus arrhythmia

[Term]
id: MP:0003930
name: abnormal tooth hard tissue morphology
def: "any structural anomaly of the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal odontoid tissue morphology" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology

[Term]
id: MP:0003931
name: absent molars
def: "absence of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MESH:A14.549.167.860.525]
is_a: MP:0006400 ! decreased molar number

[Term]
id: MP:0003932
name: abnormal molar crown morphology
def: "any structural anomaly of the part of a molar that is covered by enamel" [ISBN:0-683-40008-8]
is_a: MP:0002689 ! abnormal molar morphology

[Term]
id: MP:0003933
name: abnormal cementum morphology
def: "any strucutral anomaly in the bonelike rigid connective tissue covering the root of a tooth" [MESH:A14.549.167.646.267]
synonym: "abnormal dental cementum" EXACT []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology
is_a: MP:0030131 ! abnormal periodontium morphology

[Term]
id: MP:0003934
name: abnormal pancreas development
def: "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal pancreatogenesis" EXACT []
synonym: "pancreas dysgenesis" EXACT []
synonym: "pancreatic dysgenesis" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0003935
name: abnormal craniofacial development
def: "anomaly in the process of forming the face and/or cranium" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0000428 ! abnormal craniofacial morphology

[Term]
id: MP:0003936
name: abnormal reproductive system development
def: "developmental anomaly of any of the organs involved in the reproductive system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002160 ! abnormal reproductive system morphology

[Term]
id: MP:0003937
name: obsolete abnormal limbs/digits/tail development
def: "OBSOLETE. anomaly of the formation of the digits, autopod, limbs, or tail" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0003938
name: abnormal ear development
def: "developmental anomaly of any of the structures involved in the ear or vestibular system" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0002102 ! abnormal ear morphology

[Term]
id: MP:0003939
name: abnormal myotome morphology
def: "any structural anomaly of the mesoderm that is derived from the somite that is fated to become the musculature" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000733 ! abnormal muscle development

[Term]
id: MP:0003940
name: abnormal dermatome morphology
def: "any structural anomaly in the mesoderm that is derived from the somite that is fated to become the dermis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003941 ! abnormal skin development

[Term]
id: MP:0003941
name: abnormal skin development
def: "anomaly in the formation of the membranous protective covering of the body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0003942
name: abnormal urinary system development
def: "any anomaly in the differentiation of the organ system that produces, stores, and eliminates urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0003943
name: abnormal hepatobiliary system development
def: "developmental anomaly of any of the tissues of the liver or biliary system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal liver/biliary system development" EXACT []
is_a: MP:0002138 ! abnormal hepatobiliary system morphology

[Term]
id: MP:0003944
name: abnormal T cell subpopulation ratio
def: "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [MGI:mberry]
is_a: MP:0006387 ! abnormal T cell number
is_a: MP:0013887 ! abnormal T cell compartment

[Term]
id: MP:0003945
name: abnormal lymphocyte physiology
def: "any functional anomaly of any of the white blood cells that includes B cells, T cells, and NK cells" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0002442 ! abnormal leukocyte physiology

[Term]
id: MP:0003946
name: renal necrosis
def: "morphological changes resulting from pathological death of renal tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney necrosis" EXACT []
synonym: "necrotic kidney" EXACT []
synonym: "necrotic kidneys" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003947
name: abnormal cholesterol level
def: "anomaly in the amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005278 ! abnormal cholesterol homeostasis
is_a: MP:0012224 ! abnormal sterol level

[Term]
id: MP:0003948
name: abnormal gas homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of gaseous elements in animal tissues or blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0003949
name: abnormal circulating lipid level
def: "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "dyslipidaemia" EXACT []
synonym: "dyslipidemia" EXACT []
is_a: MP:0001547 ! abnormal lipid level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0003950
name: abnormal plasma membrane morphology
def: "any structural anomaly of the semi-permeable membrane that encloses the cytoplasm of a cell" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal cell membrane morphology" EXACT []
is_a: MP:0000358 ! abnormal cell morphology

[Term]
id: MP:0003951
name: abnormal copper homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of copper that is a cofactor in a number of proteins including amine oxidases and chaperone proteins" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0005636 ! abnormal mineral homeostasis

[Term]
id: MP:0003952
name: abnormal copper level
def: "anomaly in the concentration in the body of the metallic element atom that has formula Cu, and normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins" [CHEBI:28694, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0003951 ! abnormal copper homeostasis

[Term]
id: MP:0003953
name: abnormal hormone level
def: "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MESH:D06.472]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0003954
name: abnormal Reichert's membrane morphology
def: "any structural anomaly of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011187 ! abnormal parietal endoderm morphology

[Term]
id: MP:0003955
name: abnormal ultimobranchial body morphology
def: "any structural anomaly of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth" [PMID:20144910]
synonym: "abnormal corpus ultimopharyngeum morphology" EXACT []
synonym: "abnormal postbranchial body morphology" EXACT []
synonym: "abnormal telobranchial body morphology" EXACT []
synonym: "abnormal telopharyngeal body morphology" EXACT []
synonym: "abnormal ultimobranchial gland morphology" EXACT []
synonym: "abnormal ultimopharyngeal body morphology" EXACT []
synonym: "abnormal ultimopharyngeal gland morphology" EXACT []
is_a: MP:0003421 ! abnormal thyroid gland development
is_a: MP:0006031 ! abnormal pharyngeal pouch morphology

[Term]
id: MP:0003956
name: abnormal body size
def: "anomaly in the average body weight, height and/or length of an organism compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002089 ! abnormal postnatal growth/weight/body size

[Term]
id: MP:0003957
name: abnormal nitric oxide homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of nitric oxide, a free radical gas and a potent vasodilator" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal endothelium derived relaxation factor homeostasis" EXACT []
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0003958
name: heart valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in any of the heart valves, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic cardiac valves" EXACT []
synonym: "hyperplastic heart valves" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology

[Term]
id: MP:0003959
name: abnormal lean body mass
def: "anomaly in the amount of the fat-free physical bulk or volume of the body including all its components except adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002089 ! abnormal postnatal growth/weight/body size
is_a: MP:0005451 ! abnormal body composition

[Term]
id: MP:0003960
name: increased lean body mass
def: "greater amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0003959 ! abnormal lean body mass

[Term]
id: MP:0003961
name: decreased lean body mass
def: "reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced lean body mass" EXACT []
is_a: MP:0003959 ! abnormal lean body mass

[Term]
id: MP:0003962
name: abnormal adrenaline level
alt_id: MP:0003835
def: "aberrant concentration in the blood or tissues of this catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-0371-1954, MESH:D02.033.100.291.310]
synonym: "abnormal epinephrine level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
is_a: MP:0011479 ! abnormal catecholamine level

[Term]
id: MP:0003963
name: abnormal corticosterone level
alt_id: MP:0003837
def: "anomalous blood or tissue amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal adrenal corticosterone level" EXACT []
is_a: MP:0001547 ! abnormal lipid level
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0003964
name: abnormal noradrenaline level
alt_id: MP:0003836
def: "aberrant amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [ISBN:0198506732]
synonym: "abnormal adrenal noradrenaline level" EXACT []
synonym: "abnormal adrenal norepinephrine level" EXACT []
synonym: "abnormal norepinephrine level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
is_a: MP:0011479 ! abnormal catecholamine level

[Term]
id: MP:0003965
name: abnormal pituitary hormone level
alt_id: MP:0005125
def: "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [MGI:cwg]
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0003966
name: abnormal adrenocorticotropin level
def: "anomaly in the level of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [ISBN:0-683-40008-8]
synonym: "abnormal levels of ACTH" EXACT []
synonym: "abnormal levels of adrenocorticotropic hormone" EXACT []
synonym: "abnormal levels of adrenocorticotropin" EXACT []
synonym: "abnormal levels of adrenotropic hormone" EXACT []
synonym: "abnormal levels of adrenotropin" EXACT []
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003967
name: abnormal follicle stimulating hormone level
def: "anomalous concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8]
synonym: "abnormal follitropin level" EXACT [MESH:D06.472.699.322.576.288]
synonym: "abnormal FSH level" EXACT [MESH:D06.472.699.322.576.288]
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003968
name: abnormal growth hormone level
def: "anomalous concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [ISBN:0-683-40008-8]
synonym: "abnormal GH level" EXACT []
synonym: "abnormal pituitary growth hormone level" EXACT [MESH:D06.472.699.631.525.425]
synonym: "abnormal somatotropic hormone level" EXACT [MESH:D06.472.699.631.525.425]
synonym: "abnormal somatotropin level" EXACT [MESH:D06.472.699.631.525.425]
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003969
name: abnormal luteinizing hormone level
def: "aberrant levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [https://orcid.org/0000-0002-0371-1954, MESH:D06.472.699.322.576.463]
synonym: "abnormal ICSH level" EXACT [MESH:D06.472.699.322.576.463]
synonym: "abnormal interstitial cell-stimulating hormone level" EXACT [MESH:D06.472.699.322.576.463]
synonym: "abnormal LH level" EXACT [MESH:D06.472.699.322.576.463]
synonym: "abnormal luteinising hormone level" EXACT []
synonym: "abnormal lutropin level" EXACT [MESH:D06.472.699.322.576.463]
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003970
name: abnormal prolactin level
def: "anomalous concentration of the hormone that stimulates milk secretion" [ISBN:0-683-40008-8]
synonym: "abnormal galactopoietic hormone level" EXACT []
synonym: "abnormal lactation hormone level" EXACT []
synonym: "abnormal lactogenic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "abnormal lactotropin level" EXACT []
synonym: "abnormal mammotropic factor level" EXACT []
synonym: "abnormal mammotropic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "abnormal mammotropin level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "abnormal PRL level" EXACT [MESH:D06.472.699.322.576.773]
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003971
name: abnormal thyroid-stimulating hormone level
def: "anomalous concentration of the hormone that stimulates the growth and function of the thyroid gland" [ISBN:0-683-40008-8]
synonym: "abnormal thyropic hormone level" EXACT []
synonym: "abnormal thyrotrophin level" EXACT []
synonym: "abnormal thyrotropin level" EXACT []
synonym: "abnormal TSH level" EXACT []
is_a: MP:0003965 ! abnormal pituitary hormone level

[Term]
id: MP:0003972
name: decreased pituitary hormone level
alt_id: MP:0005126
def: "less than the expected amount of any of the pituitary hormones in the blood or tissues" [MGI:cwg]
synonym: "decreased pituitary levels of pituitary hormone" EXACT []
synonym: "reduced pituitary hormone level" EXACT []
is_a: MP:0003965 ! abnormal pituitary hormone level
is_a: MP:0014455 ! decreased hormone level

[Term]
id: MP:0003973
name: increased pituitary hormone level
alt_id: MP:0005127
def: "greater than the expected amount of any of the pituitary hormones in the blood or tissues" [MGI:cwg]
synonym: "increased pituitary levels of pituitary hormone" EXACT []
is_a: MP:0003965 ! abnormal pituitary hormone level
is_a: MP:0014454 ! increased hormone level

[Term]
id: MP:0003974
name: abnormal endocardium morphology
def: "any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [https://orcid.org/0000-0003-4606-0597, MESH:A07.541.207]
is_a: MP:0010545 ! abnormal heart layer morphology

[Term]
id: MP:0003975
name: increased circulating VLDL triglyceride level
def: "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [MGI:brs]
is_a: MP:0001552 ! increased circulating triglyceride level

[Term]
id: MP:0003976
name: decreased circulating VLDL triglyceride level
def: "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [MGI:brs]
synonym: "reduced circulating VLDL triglyceride level" EXACT []
is_a: MP:0002644 ! decreased circulating triglyceride level

[Term]
id: MP:0003977
name: abnormal circulating carnitine level
def: "aberrant concentration in the blood of carnitine, a quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [MGI:brs]
is_a: MP:0021132 ! abnormal amino acid betaine level

[Term]
id: MP:0003978
name: decreased circulating carnitine level
def: "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [MGI:brs]
synonym: "reduced circulating carnitine level" EXACT []
is_a: MP:0003977 ! abnormal circulating carnitine level
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0021134 ! decreased amino acid betaine level

[Term]
id: MP:0003979
name: increased circulating carnitine level
def: "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [MGI:brs]
is_a: MP:0003977 ! abnormal circulating carnitine level
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0021133 ! increased amino acid betaine level

[Term]
id: MP:0003980
name: increased circulating phospholipid level
def: "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0006084 ! abnormal circulating phospholipid level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0003981
name: decreased circulating phospholipid level
def: "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "reduced circulating phospholipid level" EXACT []
is_a: MP:0006084 ! abnormal circulating phospholipid level

[Term]
id: MP:0003982
name: increased cholesterol level
def: "greater than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003947 ! abnormal cholesterol level
is_a: MP:0012226 ! increased sterol level

[Term]
id: MP:0003983
name: decreased cholesterol level
def: "less than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cholesterol level" EXACT []
is_a: MP:0003947 ! abnormal cholesterol level
is_a: MP:0012225 ! decreased sterol level

[Term]
id: MP:0003984
name: embryonic growth retardation
alt_id: MP:0001692
def: "slow or limited development during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "delayed embryonic development" EXACT []
is_a: MP:0001672 ! abnormal embryo development
is_a: MP:0002088 ! abnormal embryonic growth/weight/body size
is_a: MP:0010865 ! prenatal growth retardation

[Term]
id: MP:0003985
name: renal fibrosis
def: "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [https://orcid.org/0000-0003-3691-0324]
synonym: "kidney fibrosis" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0003986
name: small cochlear ganglion
def: "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0002855 ! abnormal cochlear ganglion morphology

[Term]
id: MP:0003987
name: small vestibular ganglion
def: "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [https://orcid.org/0009-0005-7755-8314]
synonym: "small Scarpa ganglion" EXACT []
is_a: MP:0002856 ! abnormal vestibular ganglion morphology

[Term]
id: MP:0003988
name: disorganized embryonic tissue
def: "a lack of the regular arrangement of any embryonic tissues" [https://orcid.org/0000-0002-6490-7723, J:58080]
synonym: "disorganised embryonic tissue" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0003989
name: abnormal barrel cortex morphology
def: "any structural anomaly of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000860 ! abnormal primary somatosensory cortex morphology

[Term]
id: MP:0003990
name: decreased neurotransmitter release
def: "reduced production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced neurotransmitter release" EXACT []
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0003991
name: arteriosclerosis
def: "thickening, hardening and/or loss of elasticity of the walls of arteries" [MESH:C14.907.137.126]
synonym: "arterial sclerosis" EXACT []
synonym: "vascular sclerosis" EXACT []
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0003992
name: increased mortality induced by ionizing radiation
def: "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays, resulting in death" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0020149 ! abnormal mortality induced by ionizing radiation

[Term]
id: MP:0003993
name: abnormal ventral spinal root morphology
def: "any structural anomaly of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [MGI:brs]
synonym: "abnormal anterior root morphology" EXACT []
synonym: "abnormal ventral root morphology" EXACT []
is_a: MP:0001077 ! abnormal spinal nerve morphology

[Term]
id: MP:0003994
name: abnormal dorsal spinal root morphology
def: "any structural anomaly of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [MGI:brs]
synonym: "abnormal dorsal root morphology" EXACT []
synonym: "abnormal posterior root morphology" EXACT []
is_a: MP:0001077 ! abnormal spinal nerve morphology

[Term]
id: MP:0003995
name: abnormal uterine artery morphology
def: "any structural anomaly of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal metral artery morphology" EXACT []
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0003996
name: clonic seizures
def: "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000947 ! convulsive seizures

[Term]
id: MP:0003997
name: tonic-clonic seizures
def: "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [https://orcid.org/0000-0003-4606-0597]
synonym: "grand mal seizures" EXACT []
is_a: MP:0000947 ! convulsive seizures

[Term]
id: MP:0003998
name: decreased thermal nociceptive threshold
def: "a lower than average point at which thermal pain sensation is first detectable" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased thermal nociception" EXACT []
synonym: "reduced latency in hot plate test" EXACT []
synonym: "reduced thermal nociceptive threshold" EXACT []
synonym: "thermal hyperalgesia" EXACT []
is_a: MP:0002733 ! abnormal thermal nociception
is_a: MP:0005407 ! hyperalgesia

[Term]
id: MP:0003999
name: enhanced passive avoidance behavior
def: "increase in the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced passive avoidance behaviour" EXACT []
synonym: "improved passive avoidance behavior" RELATED []
synonym: "improved passive avoidance behaviour" EXACT []
is_a: MP:0002799 ! abnormal passive avoidance behavior
is_a: MP:0003459 ! increased fear-related response
is_a: MP:0012313 ! enhanced avoidance learning behavior

[Term]
id: MP:0004000
name: impaired passive avoidance behavior
def: "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002799 ! abnormal passive avoidance behavior
is_a: MP:0003460 ! decreased fear-related response
is_a: MP:0012312 ! impaired avoidance learning behavior

[Term]
id: MP:0004001
name: decreased hepatocyte proliferation
def: "reduction in the expansion rate of the hepatocyte cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced hepatocyte proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0010080 ! abnormal hepatocyte physiology

[Term]
id: MP:0004002
name: abnormal jejunum morphology
def: "any structural anomaly of the portion of the small intestine that extends from the duodenum to the ileum" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0004003
name: abnormal vascular endothelial cell physiology
def: "anomaly in the function of the cells that line the vasculature" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000249 ! abnormal blood vessel physiology

[Term]
id: MP:0004004
name: patent ductus venosus
def: "failure of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein (that allows oxygenated blood to bypass the developing liver) to close in adults" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000364 ! abnormal vascular regression
is_a: MP:0013873 ! abnormal ductus venosus morphology

[Term]
id: MP:0004005
name: impaired contractility of intestinal smooth muscle
def: "inability or reduced ability of intestinal smooth muscle to shorten or to develop increased tension" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000740 ! impaired smooth muscle contractility

[Term]
id: MP:0004006
name: impaired contractility of jejunal smooth muscle
def: "inability or reduced ability of the jejunal smooth muscle to shorter or to develop increased tension" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0004005 ! impaired contractility of intestinal smooth muscle

[Term]
id: MP:0004007
name: abnormal lung vasculature morphology
def: "any structural anomaly of the blood vessels of the lung" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0004008
name: abnormal GABA-mediated receptor currents
def: "change in the measured amplitude, current density or duration of response to stimulation of GABA receptors" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal gamma-amino-n-butyric acid receptor currents" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0004009
name: abnormal diastolic filling velocity
def: "anomaly in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:cur]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0004010
name: increased diastolic filling velocity
def: "greater rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:cur]
is_a: MP:0004009 ! abnormal diastolic filling velocity

[Term]
id: MP:0004011
name: decreased diastolic filling velocity
def: "reduction in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:cur]
synonym: "reduced diastolic filling velocity" EXACT []
is_a: MP:0004009 ! abnormal diastolic filling velocity

[Term]
id: MP:0004012
name: increased pulmonary artery pressure
def: "increased pulmonary pressure compared to controls" [RGD:cur]
is_a: MP:0003547 ! abnormal pulmonary pressure

[Term]
id: MP:0004013
name: decreased pulmonary artery pressure
def: "reduced pulmonary pressure compared to controls" [RGD:cur]
synonym: "reduced pulmonary artery pressure" EXACT []
is_a: MP:0003547 ! abnormal pulmonary pressure

[Term]
id: MP:0004014
name: abnormal uterine environment
def: "anomaly or inability of the uterus to support embryonic development" [MGI:llw2]
synonym: "abnormal metral environment" EXACT []
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0004015
name: abnormal oviduct environment
def: "anomaly or inability of the oviduct to support egg viability" [MGI:llw2]
is_a: MP:0012018 ! abnormal oviduct physiology

[Term]
id: MP:0004016
name: decreased bone mass
def: "a reduction in the total amount of bone tissue contained in the skeleton" [https://orcid.org/0009-0005-7755-8314]
synonym: "reduced bone mass" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0004017
name: duplex kidney
def: "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [MGI:rbabiuk]
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0004018
name: abnormal galactose homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of galactose in the fluids and tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0004019
name: abnormal vitamin homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function" [https://orcid.org/0000-0003-3691-0324, MESH:D27.505.696.377.605.600]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0004020
name: polyhydramnios
def: "abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities" [https://orcid.org/0009-0005-7755-8314]
synonym: "hydramnios" EXACT []
synonym: "polyamnios" EXACT []
synonym: "polyhydramnion" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation

[Term]
id: MP:0004021
name: abnormal rod electrophysiology
def: "any functional anomaly of dark adapted vision mediated by the rods" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal scotopic response" EXACT []
is_a: MP:0005551 ! abnormal eye electrophysiology

[Term]
id: MP:0004022
name: abnormal cone electrophysiology
def: "any functional anomaly of light adapted vision mediated by the cones" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal photopic response" EXACT []
is_a: MP:0005551 ! abnormal eye electrophysiology

[Term]
id: MP:0004023
name: abnormal chromosome number
def: "chromosome count is other than the expected diploid chromosome number" [MGI:llw2]
is_a: MP:0003702 ! abnormal chromosome morphology

[Term]
id: MP:0004024
name: aneuploidy
def: "chromosome count is not an exact multiple of the haploid number" [ISBN:0-683-40008-8, MGI:llw2]
is_a: MP:0004023 ! abnormal chromosome number

[Term]
id: MP:0004025
name: polyploidy
def: "more than two chromosome sets are present" [MGI:llw2]
is_a: MP:0004023 ! abnormal chromosome number

[Term]
id: MP:0004026
name: monosomy
def: "one chromosome missing from an otherwise diploid chromosome set" [MGI:llw2]
is_a: MP:0004024 ! aneuploidy

[Term]
id: MP:0004027
name: trisomy
def: "presence of an extra chromosome in an otherwise diploid chromosome set" [MGI:llw2]
is_a: MP:0004024 ! aneuploidy

[Term]
id: MP:0004028
name: chromosome breakage
alt_id: MP:0002008
def: "chromosome instability in the form of increased frequency of spontaneous breakage with or without rearrangements" [MGI:llw2]
is_a: MP:0008866 ! chromosomal instability

[Term]
id: MP:0004029
name: spontaneous chromosome breakage
def: "chromosome breakage due to inherent instability of chromosomes" [MGI:llw2]
is_a: MP:0004028 ! chromosome breakage

[Term]
id: MP:0004030
name: induced chromosome breakage
def: "chromosome breakage following treatment with a DNA-damaging agent" [MGI:llw2]
is_a: MP:0004028 ! chromosome breakage

[Term]
id: MP:0004031
name: insulitis
def: "a histological change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [MGI:rbabiuk]
synonym: "intra-insulitis" EXACT []
is_a: MP:0001869 ! pancreas inflammation

[Term]
id: MP:0004032
name: abnormal interventricular groove morphology
def: "any structural anomaly of the indentation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal interventricular sulcus morphology" EXACT []
is_a: MP:0005294 ! abnormal heart ventricle morphology

[Term]
id: MP:0004033
name: supernumerary teeth
def: "presence of a supernumerary, i.e., extra, tooth or teeth" [HP:0011069, https://orcid.org/0000-0002-6490-7723]
synonym: "extra teeth" EXACT []
synonym: "hyperdontia" EXACT []
synonym: "increased number of teeth" EXACT []
synonym: "increased tooth count" EXACT []
synonym: "increased tooth number" EXACT []
synonym: "polydontia" EXACT []
synonym: "supernumerary dentition" EXACT []
synonym: "supplemental dentition" EXACT []
synonym: "supplemental teeth" EXACT []
is_a: MP:0030611 ! abnormal tooth number

[Term]
id: MP:0004034
name: belly blaze
def: "the appearance of a stripe or zigzag of white fur on the ventrum" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0004035
name: abnormal sublingual gland morphology
def: "any structural anomaly of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [MGI:hdene]
synonym: "abnormal Rivinus gland morphology" EXACT []
is_a: MP:0003792 ! abnormal major salivary gland morphology

[Term]
id: MP:0004036
name: abnormal muscle relaxation
def: "altered ability of the muscle to lengthen following contractions" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0004037
name: increased muscle relaxation
def: "greater than the normal ability of the muscle to lengthen following contractions or increase in the ability of the muscle to lengthen following contractions" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0004036 ! abnormal muscle relaxation

[Term]
id: MP:0004038
name: lymphangiectasis
alt_id: MP:0010201
def: "stretched or widened aperture of the luminal space of one or more of the lymphatic vessels" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "dilated lymphatic vessel" EXACT []
synonym: "dilated lymphatic vessels" EXACT []
synonym: "lymphangiectasia" EXACT []
synonym: "lymphatic vessel dilation" EXACT []
synonym: "lymphectasia" EXACT []
synonym: "telangiectasia lymphatica" EXACT []
xref: Fyler:4042
is_a: MP:0010200 ! enlarged lymphatic vessel

[Term]
id: MP:0004039
name: abnormal cardiac muscle cell glucose uptake
def: "anomalous ability of the cells of the heart muscle to take in glucose" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0004130 ! abnormal muscle cell glucose uptake

[Term]
id: MP:0004040
name: abnormal susceptibility to kidney reperfusion injury
def: "a change in the likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [MGI:brs]
synonym: "abnormal resistance to kidney reperfusion injury" EXACT []
synonym: "abnormal response to renal IRI" BROAD [PMID:37452495]
synonym: "abnormal susceptibility to renal ischemia/reperfusion injury" EXACT [PMID:37452495]
synonym: "altered susceptibility to kidney reperfusion injury" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0004041
name: increased susceptibility to kidney reperfusion injury
def: "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [MGI:brs]
synonym: "decreased resistance to kidney reperfusion injury" EXACT []
synonym: "increased response to renal IRI" BROAD [PMID:37452495]
synonym: "increased susceptibility to renal ischemia/reperfusion injury" EXACT [PMID:37452495]
is_a: MP:0004040 ! abnormal susceptibility to kidney reperfusion injury

[Term]
id: MP:0004042
name: decreased susceptibility to kidney reperfusion injury
def: "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [MGI:brs]
synonym: "decreased response to renal IRI" BROAD [PMID:37452495]
synonym: "decreased susceptibility to renal ischemia/reperfusion injury" EXACT [PMID:37452495]
synonym: "increased resistance to kidney reperfusion injury" EXACT []
synonym: "reduced susceptibility to kidney reperfusion injury" EXACT []
is_a: MP:0004040 ! abnormal susceptibility to kidney reperfusion injury
is_a: MP:0005166 ! decreased susceptibility to injury

[Term]
id: MP:0004043
name: abnormal pH regulation
def: "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0004044
name: aortic dissection
def: "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000272 ! abnormal aorta morphology

[Term]
id: MP:0004045
name: abnormal cell cycle checkpoint function
def: "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003077 ! abnormal cell cycle

[Term]
id: MP:0004046
name: abnormal mitosis
def: "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis)" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003077 ! abnormal cell cycle

[Term]
id: MP:0004047
name: abnormal milk composition
def: "anomaly in one or more of the constituents of milk including protein, lipid, and/or mineral content or in the appearance of milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001882 ! abnormal lactation

[Term]
id: MP:0004048
name: obsolete increased resistance to addictive substance
def: "OBSOLETE. increased threshold to obtain a physiological or behavioral response to an addictive substance" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased sensitivity to addictive substance" EXACT []
synonym: "decreased susceptibility to addictive substance" EXACT []
is_obsolete: true

[Term]
id: MP:0004049
name: increased acute promyelocytic leukemia incidence
def: "higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [ISBN:0-683-40008-8]
synonym: "acute promyelocytic leukaemia" RELATED []
synonym: "acute promyelocytic leukemia" RELATED []
synonym: "increased acute promyelocytic leukaemia incidence" EXACT []
is_a: MP:0002026 ! increased leukemia incidence

[Term]
id: MP:0004050
name: abnormal renal sympathetic nerve activity
def: "any anomaly in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function" [PMID:29651418]
synonym: "abnormal RSNA" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0004051
name: increased renal sympathetic nerve activity
def: "elevation in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function" [PMID:29651418]
synonym: "elevated RSNA" EXACT []
is_a: MP:0004050 ! abnormal renal sympathetic nerve activity

[Term]
id: MP:0004052
name: decreased renal sympathetic nerve activity
def: "reduction in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function" [PMID:29651418]
synonym: "reduced renal sympathetic nerve activity" EXACT []
synonym: "reduced RSNA" EXACT []
is_a: MP:0004050 ! abnormal renal sympathetic nerve activity

[Term]
id: MP:0004053
name: abnormal synchondrosis
def: "anomalous or persistent cartilaginous fusion of two bones" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000164 ! abnormal cartilage development
is_a: MP:0030875 ! abnormal cartilaginous joint morphology

[Term]
id: MP:0004054
name: abnormal periocular mesenchyme morphology
def: "any structural anomaly of the mesenchymal cells that give rise to the corneal endothelium, corneal stroma, sclera, iris stroma, ciliary muscle, ciliary stroma, and trabecular meshwork of the eye" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0011260 ! abnormal head mesenchyme morphology

[Term]
id: MP:0004055
name: heart atrium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart atrium, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "atria hypoplasia" EXACT []
synonym: "cardiac atrial hypoplasia" EXACT []
synonym: "hypoplastic atria" EXACT []
is_a: MP:0031577 ! decreased heart atrium size

[Term]
id: MP:0004056
name: abnormal myocardium compact layer morphology
alt_id: MP:0010550
def: "any structural anomaly of the outer, dense layer of the myocardium uniting the epicardium and myocardium" [http://www.dorlands.com/, https://orcid.org/0000-0002-6490-7723]
comment: Note that the synonyms "subepicardium layer" and "subepicardial layer" are used in older literature to refer to the myocardium compact layer.
synonym: "abnormal compact subepicardial layer morphology" EXACT []
synonym: "abnormal compact subepicardial myocardium morphology" RELATED []
synonym: "abnormal heart compact layer" EXACT []
synonym: "abnormal myocardial compact layer morphology" EXACT []
synonym: "abnormal subepicardial layer morphology" EXACT []
synonym: "abnormal subepicardium layer morphology" RELATED []
synonym: "abnormal subepicardium morphology" EXACT []
is_a: MP:0005329 ! abnormal myocardium layer morphology

[Term]
id: MP:0004057
name: thin myocardium compact layer
def: "reduced thickness of the outer, dense layer of the myocardium" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin myocardial compact layer" EXACT []
is_a: MP:0004056 ! abnormal myocardium compact layer morphology

[Term]
id: MP:0004058
name: abnormal ventricle papillary muscle morphology
alt_id: MP:0004059
def: "any structural anomaly of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal musculus papillaris morphology" EXACT []
synonym: "abnormal ventricular papillary muscle morphology" EXACT []
synonym: "dysplastic papillary muscle" NARROW []
synonym: "papillary muscle dysplasia" NARROW []
is_a: MP:0010499 ! abnormal ventricle myocardium morphology

[Term]
id: MP:0004060
name: absent papillary muscle
def: "absence of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004058 ! abnormal ventricle papillary muscle morphology

[Term]
id: MP:0004061
name: papillary muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the papillary muscle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic papillary muscle" EXACT []
is_a: MP:0031539 ! decreased papillary muscle size

[Term]
id: MP:0004062
name: dilated heart right atrium
def: "the luminal space of the right upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
synonym: "cardiac right atrial dilation" EXACT []
synonym: "cardiac right atrium dilation" EXACT []
synonym: "dilated cardiac right atria" EXACT []
synonym: "dilated cardiac right atrium" EXACT []
synonym: "dilated heart right atria" EXACT []
synonym: "heart right atrium dilation" EXACT []
synonym: "right atrial dilation" EXACT []
xref: Fyler:2859
is_a: MP:0003140 ! dilated heart atrium
is_a: MP:0003922 ! abnormal heart right atrium morphology

[Term]
id: MP:0004063
name: dilated heart left atrium
def: "the luminal space of the left upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
synonym: "cardiac left atrial dilation" EXACT []
synonym: "cardiac left atrium dilation" EXACT []
synonym: "dilated cardiac left atria" EXACT []
synonym: "dilated cardiac left atrium" EXACT []
synonym: "dilated heart left atria" EXACT []
synonym: "heart left atrial dilation" EXACT []
synonym: "left atrium dilation" EXACT []
xref: Fyler:3020
is_a: MP:0003140 ! dilated heart atrium
is_a: MP:0003923 ! abnormal heart left atrium morphology

[Term]
id: MP:0004064
name: decreased susceptibility to induced muscular atrophy
def: "less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased resistance to induced muscular atrophy" EXACT []
is_a: MP:0002269 ! muscular atrophy

[Term]
id: MP:0004065
name: increased susceptibility to induced muscular atrophy
def: "greater than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to induced muscular atrophy" EXACT []
is_a: MP:0002269 ! muscular atrophy

[Term]
id: MP:0004066
name: abnormal primitive node morphology
def: "any structural anomaly of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorly to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal embryonic node morphology" EXACT []
synonym: "abnormal Hensen's node morphology" RELATED []
synonym: "abnormal Henson's node morphology" RELATED []
synonym: "abnormal primitive knot morphology" EXACT []
synonym: "abnormal prochordal knot morphology" EXACT []
synonym: "abnormal Spemann's organizer morphology" RELATED []
is_a: MP:0002231 ! abnormal primitive streak morphology

[Term]
id: MP:0004067
name: abnormal trabecula carnea morphology
def: "any structural anomaly of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal columnae carneae morphology" EXACT []
synonym: "abnormal fleshy beams" EXACT []
synonym: "abnormal Rathke bundle morphology" RELATED []
synonym: "abnormal ventricular trabeculae morphology" EXACT []
is_a: MP:0002189 ! abnormal myocardial trabeculae morphology
is_a: MP:0010499 ! abnormal ventricle myocardium morphology

[Term]
id: MP:0004068
name: dilated dorsal aorta
def: "stretched or widened aperture of the luminal space of one or both of the pair of arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated dorsal aortae" EXACT []
synonym: "dilated dorsal aortas" EXACT []
synonym: "dorsal aorta dilation" EXACT []
is_a: MP:0004787 ! abnormal dorsal aorta morphology

[Term]
id: MP:0004069
name: abnormal muscle spindle morphology
def: "any structural anomaly of the sensory organs in muscle that are involved in the stretch reflex" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "abnormal Kuhne spindle" EXACT []
synonym: "abnormal neuromuscular spindle morphology" EXACT []
is_a: MP:0000990 ! abnormal skeletal muscle mechanoreceptor morphology

[Term]
id: MP:0004070
name: abnormal P wave
def: "any anomaly in the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006142 ! abnormal sinoatrial node conduction
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature

[Term]
id: MP:0004071
name: prolonged P wave
def: "increase in the length of time of the P wave electrical impulses, measured from the beginning to the end of the P wave" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased P wave width" EXACT []
is_a: MP:0004070 ! abnormal P wave
is_a: MP:0010520 ! sinoatrial block

[Term]
id: MP:0004072
name: abnormal frontal plane axis
def: "any anomaly found in the sum of all electrical currents in the heart during systole" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal electrical axis of the heart" EXACT []
is_a: MP:0003137 ! abnormal impulse conducting system conduction

[Term]
id: MP:0004073
name: caudal body truncation
def: "caudal part of body truncated; typically with the rostral portion of the body relatively normal" [https://orcid.org/0000-0003-3691-0324]
synonym: "caudal truncation(s)" EXACT []
synonym: "posterior body truncation" EXACT []
synonym: "posterior truncation(s)" EXACT []
is_a: MP:0005221 ! abnormal rostral-caudal axis patterning

[Term]
id: MP:0004074
name: abnormal Schwann cell precursor morphology
def: "any structural anomaly of the progenitors of cells that sheath the axons of the peripheral nervous system" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal Schwann cell precursors" BROAD []
is_a: MP:0001106 ! abnormal Schwann cell morphology

[Term]
id: MP:0004075
name: decreased Schwann cell precursor number
def: "fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system" [https://orcid.org/0009-0005-7755-8314]
synonym: "reduced Schwann cell precursor number" EXACT []
is_a: MP:0004074 ! abnormal Schwann cell precursor morphology

[Term]
id: MP:0004076
name: abnormal vitelline vascular remodeling
def: "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology

[Term]
id: MP:0004077
name: abnormal striatum morphology
def: "any structural anomaly of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal neostriatum morphology" EXACT []
synonym: "abnormal striate body" EXACT []
is_a: MP:0000787 ! abnormal telencephalon morphology
is_a: MP:0006007 ! abnormal basal ganglion morphology

[Term]
id: MP:0004078
name: abnormal caudate nucleus morphology
def: "any structural anomaly of one or both C-shaped structures that border the lateral ventricle wall and contain input neurons involved with control of voluntary movement in the brain" [ISBN:0-683-40008-8, ISBN:0838580343]
is_a: MP:0004102 ! abnormal dorsal striatum morphology

[Term]
id: MP:0004079
name: abnormal putamen morphology
def: "any structural anomaly of the lens-shaped basal ganglion involved with control of voluntary movement in the brain" [ISBN:0838580343]
is_a: MP:0004102 ! abnormal dorsal striatum morphology

[Term]
id: MP:0004080
name: abnormal nucleus accumbens morphology
def: "any structural anomaly of the group of neurons located at the head of the caudate nucleus and anterior to the putamen; these neurons normally are involved in sensations of pleasure and reactions to addictive substances" [ISBN:0838580343]
synonym: "abnormal accumbens nucleus morphology" EXACT []
synonym: "abnormal Nacc morphology" EXACT []
is_a: MP:0004103 ! abnormal ventral striatum morphology
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0004081
name: abnormal globus pallidus morphology
def: "any structural anomaly of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [ISBN:0838580343]
synonym: "abnormal paleostriatum" EXACT []
synonym: "abnormal pallidum morphology" EXACT []
is_a: MP:0000830 ! abnormal diencephalon morphology
is_a: MP:0006007 ! abnormal basal ganglion morphology

[Term]
id: MP:0004082
name: abnormal habenula morphology
def: "any structural anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [https://orcid.org/0000-0003-3691-0324]
comment: Note that the habenula term originally denoted the stalk of the pineal gland, but now refers to the habenular nucleus, a neighboring group of neurons in the epithalamus.
synonym: "abnormal habenular nucleus morphology" EXACT []
is_a: MP:0000840 ! abnormal epithalamus morphology

[Term]
id: MP:0004083
name: polysyndactyly
def: "greater than the normal complement of digits present on an autopod with interdigital webbing also present" [MGI:rbabiuk]
subset: IMPC
subset: Sanger_Terms
synonym: "polydactylous syndactyly" EXACT []
synonym: "synpolydactyly" EXACT []
is_a: MP:0000562 ! polydactyly
is_a: MP:0000564 ! syndactyly

[Term]
id: MP:0004084
name: abnormal cardiac muscle relaxation
def: "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0004036 ! abnormal muscle relaxation

[Term]
id: MP:0004085
name: abnormal heartbeat
def: "anomaly in the appearance of regularly spaced contractions of the heart due to defects in the frequency, rate, pattern or extent of heart contraction" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiac contraction" EXACT []
synonym: "abnormal heart beat" EXACT []
synonym: "abnormal heart beating" EXACT []
synonym: "abnormal heart contraction" EXACT []
synonym: "abnormal heart rhythm" NARROW []
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0004086
name: absent heartbeat
def: "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [https://orcid.org/0000-0002-6490-7723]
synonym: "asystole" EXACT []
is_a: MP:0004085 ! abnormal heartbeat

[Term]
id: MP:0004087
name: abnormal muscle fiber morphology
def: "any structural anomaly of the muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal muscle fibre morphology" EXACT []
synonym: "muscle fiber dysplasia" NARROW []
synonym: "muscle fibre dysplasia" NARROW []
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0004088
name: abnormal sarcoplasmic reticulum morphology
def: "any structural anomaly in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004087 ! abnormal muscle fiber morphology

[Term]
id: MP:0004089
name: dilated sarcoplasmic reticulum
def: "an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere" [https://orcid.org/0000-0002-6490-7723]
synonym: "sarcoplasmic reticulum dilation" EXACT []
is_a: MP:0004088 ! abnormal sarcoplasmic reticulum morphology

[Term]
id: MP:0004090
name: abnormal sarcomere morphology
def: "any structural anomaly in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0004087 ! abnormal muscle fiber morphology

[Term]
id: MP:0004091
name: abnormal Z line morphology
def: "any structural anomaly in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intermediate disc" BROAD []
synonym: "abnormal intermediate disk" BROAD []
synonym: "abnormal Z band" BROAD []
synonym: "abnormal Z disc" BROAD []
synonym: "abnormal Z disk" BROAD []
synonym: "abnormal Z line" BROAD []
synonym: "abnormal Z lines" BROAD []
synonym: "abnormal Z-line morphology" EXACT []
is_a: MP:0030567 ! abnormal I band morphology

[Term]
id: MP:0004092
name: absent Z line
def: "missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent Z band" EXACT []
synonym: "absent Z disc" EXACT []
synonym: "absent Z disk" EXACT []
synonym: "absent Z lines" EXACT []
synonym: "absent Z-line" EXACT []
is_a: MP:0004091 ! abnormal Z line morphology

[Term]
id: MP:0004093
name: diffuse Z line
def: "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [https://orcid.org/0000-0002-6490-7723]
synonym: "diffuse Z band" EXACT []
synonym: "diffuse Z disc" EXACT []
synonym: "diffuse Z disk" EXACT []
synonym: "diffuse Z lines" EXACT []
synonym: "diffuse Z-line" EXACT []
is_a: MP:0004091 ! abnormal Z line morphology

[Term]
id: MP:0004094
name: abnormal M line morphology
def: "any structural anomaly of the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal M band" BROAD []
synonym: "abnormal M disc" BROAD []
synonym: "abnormal M disk" BROAD []
synonym: "abnormal M line" BROAD []
synonym: "abnormal M lines" BROAD []
synonym: "abnormal M-line morphology" EXACT []
synonym: "abnormal mesophragma" BROAD []
is_a: MP:0030566 ! abnormal A band morphology

[Term]
id: MP:0004095
name: ocular distichiasis
def: "presence of a double row of eyelashes on an eyelid, one or both of which are turned in against the eyeball" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0013895 ! abnormal eyelid cilium morphology

[Term]
id: MP:0004096
name: abnormal midbrain-hindbrain boundary development
def: "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal isthmic organizer development" EXACT []
synonym: "abnormal isthmomesencephalic boundary development" EXACT []
synonym: "abnormal isthmus development" EXACT []
synonym: "abnormal isthmus organizer development" EXACT []
synonym: "abnormal MHB development" EXACT []
synonym: "abnormal midbrain-hindbrain organizer development" EXACT []
is_a: MP:0012132 ! abnormal midbrain-hindbrain boundary morphology

[Term]
id: MP:0004097
name: abnormal cerebellar cortex morphology
def: "any structural anomaly of the thin mantle of grey matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
is_a: MP:0000849 ! abnormal cerebellum morphology

[Term]
id: MP:0004098
name: abnormal cerebellar granule cell morphology
def: "any structural anomaly of the small neurons of the cerebellar granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343]
synonym: "abnormal cerebellar granule neuron morphology" EXACT []
synonym: "abnormal granule cell" BROAD []
synonym: "abnormal granule neuron" BROAD []
xref: CL:0001031
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0004099
name: abnormal cerebellar glomerulus morphology
def: "any structural anomaly of an intertwined cluster of nerve fibers surrounded by glia where mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons" [ISBN:0838580343]
synonym: "abnormal cerebellar glomeruli" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0004100
name: abnormal spinal cord interneuron morphology
def: "any structural anomaly of neurons that exclusively interact with other neurons in the spinal cord" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002882 ! abnormal neuron morphology
is_a: MP:0008503 ! abnormal spinal cord grey matter morphology

[Term]
id: MP:0004101
name: abnormal brain interneuron morphology
def: "any structural anomaly of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0004102
name: abnormal dorsal striatum morphology
def: "any structural anomaly of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [ISBN:0-683-40008-8]
synonym: "abnormal caudate putamen complex" EXACT []
synonym: "abnormal caudate-putamen morphology" EXACT []
synonym: "abnormal caudatoputamen morphology" EXACT []
synonym: "abnormal dorsal basal ganglia" EXACT []
is_a: MP:0004077 ! abnormal striatum morphology

[Term]
id: MP:0004103
name: abnormal ventral striatum morphology
def: "any structural anomaly of the regions of the nucleus accumbens and some nuclei of the olfactory tubercle that lie ventral to the anterior commissure" [ISBN:0-683-40008-8]
is_a: MP:0004077 ! abnormal striatum morphology

[Term]
id: MP:0004105
name: cornea abrasion
def: "scraping away or denuding of the corneal surface" [https://orcid.org/0000-0002-6490-7723]
synonym: "corneal abrasion" EXACT []
synonym: "tunica cornea abrasion" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0004106
name: lymphatic vessel hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lymphatic vessels, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic lymphatic vessel" EXACT []
synonym: "hyperplastic lymphatic vessels" EXACT []
is_a: MP:0010200 ! enlarged lymphatic vessel

[Term]
id: MP:0004107
name: abnormal thoracic duct morphology
def: "any structural anomaly in the largest collecting lymph vessel in the body, beginning at the cisterna chyli at about the level of the second lumbar vertebra, and drains into the systemic (blood) circulation at the left brachiocephalic vein between the left subclavian and left internal jugular veins" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal alimentary duct morphology" EXACT []
synonym: "abnormal chyliferous duct morphology" EXACT []
synonym: "abnormal ductus thoracicus morphology" EXACT []
synonym: "abnormal left lymphatic duct morphology" EXACT []
synonym: "abnormal Pecquet duct morphology" EXACT []
synonym: "abnormal Van Hoorne's canal morphology" EXACT []
synonym: "abnormal van Horne canal morphology" EXACT []
is_a: MP:0001879 ! abnormal lymphatic vessel morphology

[Term]
id: MP:0004108
name: abnormal esophageal peristalsis
def: "altered esophageal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls that move the esophagus contents forward" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal oesophageal peristalsis" EXACT []
is_a: MP:0005620 ! abnormal muscle contractility
is_a: MP:0011082 ! abnormal gastrointestinal motility

[Term]
id: MP:0004109
name: abnormal Sertoli cell development
def: "anomalous differentiation of cells that support germ cell differentiation in males" [MGI:llw2]
is_a: MP:0003830 ! abnormal testis development

[Term]
id: MP:0004110
name: transposition of great arteries
alt_id: MP:0006127
def: "cardiovascular structural anomaly in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [https://orcid.org/0009-0005-7755-8314]
subset: CvDC_Terms
synonym: "discordant VA connections" EXACT []
synonym: "TGA" EXACT []
synonym: "transposition of great vessels" BROAD []
is_a: MP:0010426 ! abnormal heart and great artery attachment

[Term]
id: MP:0004111
name: abnormal coronary artery morphology
def: "any structural anomaly of any of the arteries that branch from the ascending aorta to supply blood to the heart" [https://orcid.org/0009-0005-7755-8314]
subset: CvDC_Terms
synonym: "congenital coronary anomaly" BROAD []
synonym: "coronary arterial dysplasia" NARROW []
xref: Fyler:3100
is_a: MP:0010551 ! abnormal coronary vessel morphology
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0004112
name: abnormal arteriole morphology
def: "any structural anomaly of the small diameter vessels that branch from the arteries and lead to the capillaries" [MESH:A07.231.114.060]
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0004113
name: abnormal aortic arch morphology
def: "any structural anomaly of the convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8]
comment: Note that this term refers to the adult aortic arch structure. For multiple aortic arches present in the embryo, see the term for embryonic aortic arches [abnormal branchial arch artery morphology; MP:0002672].
subset: CvDC_Terms
synonym: "abnormal adult aortic arch" EXACT []
synonym: "abnormal arch of aorta" EXACT []
synonym: "abnormal arch of the aorta" EXACT []
synonym: "aortic arch abnormality" EXACT []
xref: Fyler:2700
xref: MA:0000475
is_a: MP:0010468 ! abnormal thoracic aorta morphology

[Term]
id: MP:0004114
name: abnormal atrioventricular node morphology
def: "any structural anomaly of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MESH:A07.541.409.147]
synonym: "abnormal A-V node" EXACT []
synonym: "abnormal atrio-ventricular node" EXACT []
synonym: "abnormal AV node" EXACT []
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0004123 ! abnormal impulse conducting system morphology

[Term]
id: MP:0004115
name: abnormal sinoatrial node morphology
def: "any structural anomaly of the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atrium that is the source of contraction impulses for the heart" [MESH:A07.541.409.819]
synonym: "abnormal pacemaker" EXACT []
synonym: "abnormal SA node" EXACT []
synonym: "abnormal SAN morphology" EXACT []
synonym: "abnormal sinu-atrial node" EXACT []
synonym: "abnormal sinuatrial node" EXACT []
synonym: "abnormal sinus node" EXACT []
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0004123 ! abnormal impulse conducting system morphology

[Term]
id: MP:0004116
name: abnormal atrioventricular bundle conduction
def: "anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MESH:A07.541.409.273]
synonym: "abnormal bundle of His conduction" EXACT []
is_a: MP:0003137 ! abnormal impulse conducting system conduction

[Term]
id: MP:0004117
name: abnormal atrioventricular bundle morphology
def: "any structural anomaly of the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MESH:A07.541.409.273]
synonym: "abnormal atrioventricular band morphology" EXACT []
synonym: "abnormal bundle of His" EXACT []
synonym: "abnormal Gaskell bridge morphology" EXACT []
synonym: "abnormal His band morphology" EXACT []
synonym: "abnormal His bundle" EXACT []
synonym: "abnormal Keith bundle morphology" EXACT []
synonym: "abnormal Kent bundle morphology" EXACT []
synonym: "abnormal Kent-His bundle morphology" RELATED []
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0004123 ! abnormal impulse conducting system morphology

[Term]
id: MP:0004118
name: abnormal baroreceptor morphology
def: "any structural anomaly in the sensory nerve endings in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [ISBN:0-683-40008-8]
synonym: "abnormal pressoreceptor morphology" EXACT []
is_a: MP:0000972 ! abnormal mechanoreceptor morphology

[Term]
id: MP:0004119
name: hypokalemia
def: "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [ISBN:0-683-40008-8]
synonym: "hypokalaemia" EXACT []
synonym: "hypopotassaemia" EXACT []
synonym: "hypopotassemia" EXACT []
is_a: MP:0005628 ! decreased circulating potassium level

[Term]
id: MP:0004120
name: cardiac ischemia
def: "inadequate blood flow to the heart; may cause infarction and is usually caused by coronary artery disease" [ISBN:0-683-40008-8]
synonym: "cardiac ischaemia" EXACT []
is_a: MP:0006111 ! abnormal coronary circulation

[Term]
id: MP:0004121
name: abnormal sarcolemma morphology
def: "any structural anomaly in the plasma membrane of a muscle fiber that is capable of conducting electrical impulses" [ISBN:0-683-40008-8]
synonym: "abnormal myolemma morphology" EXACT []
is_a: MP:0004087 ! abnormal muscle fiber morphology

[Term]
id: MP:0004122
name: abnormal sinus arrhythmia
def: "any anomaly in the normal phenomenon of mild acceleration and slowing of the heart rate that occurs during the respiratory cycle" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal heart rate variability" RELATED []
synonym: "abnormal respiratory sinus arrythmia" EXACT []
synonym: "abnormal RSA" EXACT []
synonym: "abnormal SA" EXACT []
xref: Fyler:7011
is_a: MP:0001629 ! abnormal heart rate

[Term]
id: MP:0004123
name: abnormal impulse conducting system morphology
def: "any structural anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [MESH:A07.541.409]
synonym: "abnormal bundle of Kent" EXACT []
synonym: "abnormal heart conducting system" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology

[Term]
id: MP:0004124
name: abnormal Purkinje fiber morphology
def: "any structural anomaly in the cardiac muscle fibers composing the terminal portion of the heart conduction system located in the ventricle" [MESH:A07.541.409.683]
synonym: "abnormal Purkinje fibre morphology" EXACT []
is_a: MP:0004123 ! abnormal impulse conducting system morphology

[Term]
id: MP:0004125
name: abnormal venule morphology
def: "any structural anomaly of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MESH:A07.231.432.952]
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0004126
name: thin hypodermis
def: "reduced thickness of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003705 ! abnormal hypodermis morphology

[Term]
id: MP:0004127
name: thick hypodermis
def: "increase in the width of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003705 ! abnormal hypodermis morphology

[Term]
id: MP:0004129
name: abnormal respiratory quotient
def: "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal respiratory coefficient" EXACT []
synonym: "abnormal respiratory exchange ratio" EXACT []
synonym: "abnormal RQ" EXACT []
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0004130
name: abnormal muscle cell glucose uptake
def: "anomaly in the ability of muscle cells to take in glucose" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002106 ! abnormal muscle physiology
is_a: MP:0003925 ! abnormal cellular glucose uptake

[Term]
id: MP:0004131
name: abnormal motile primary cilium morphology
def: "any structural anomaly of the cilia of the embryo found on the cells of the embryonic node, which generate flow of extraembryonic fluid surrounding the node in a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization" [GO:0031512, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal embryonic cilia morphology" EXACT []
synonym: "abnormal embryonic ciliary morphology" EXACT []
synonym: "abnormal embryonic cilium morphology" BROAD []
synonym: "abnormal motile primary cilia morphology" EXACT []
synonym: "abnormal nodal cilium morphology" EXACT []
is_a: MP:0004066 ! abnormal primitive node morphology
is_a: MP:0013203 ! abnormal primary cilium morphology
is_a: MP:0013206 ! abnormal motile cilium morphology

[Term]
id: MP:0004132
name: absent embryonic cilia
def: "absence of cilia on the cells of the embryonic node" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent embryonic ciliary" EXACT []
synonym: "absent motile primary cilia" EXACT []
synonym: "absent motile primary cilium" EXACT []
synonym: "absent nodal cilium" EXACT []
is_a: MP:0004131 ! abnormal motile primary cilium morphology

[Term]
id: MP:0004133
name: heterotaxia
def: "abnormal arrangement of organs or parts of the body in relation to each other according to the left-right axis" [https://orcid.org/0000-0002-6490-7723, PMID:16461029]
subset: CvDC_Terms
synonym: "abnormal bilateral symmetry" EXACT []
synonym: "heterotaxis" EXACT []
synonym: "heterotaxy" EXACT []
synonym: "heterotaxy syndrome" RELATED []
xref: Fyler:0190
xref: Fyler:190
xref: MPATH:712
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0004134
name: abnormal chest morphology
def: "any structural anomaly of the part of the body between the neck and the abdomen" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal thorax morphology" EXACT []
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0004135
name: abnormal mammary gland embryonic development
def: "aberration in the differentiation of the mammary gland during early embryogenesis" [https://orcid.org/0000-0003-4606-0597, MGI:llw2]
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0004136
name: abnormal tongue muscle morphology
def: "any structural anomaly of the muscular portion of the tongue" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal lingual muscle morphology" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0004137
name: abnormal gastric surface mucous cell morphology
def: "any structural anomaly of the mucus secreting epithelial cells that line the luminal surface of the stomach and the gastric pits which secrete mucus and HCO3- to protect the gastric surface from the acidic environment of the stomach" [https://orcid.org/0009-0005-7755-8314, ISBN:0781768527]
synonym: "abnormal gastric surface mucous cells" BROAD []
is_a: MP:0010792 ! abnormal stomach mucosa morphology

[Term]
id: MP:0004138
name: abnormal mucous neck cell morphology
def: "any structural anomaly of the mucin-producing epithelial cells present in the neck of the gastric glands" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0003892 ! abnormal gastric gland morphology
is_a: MP:0004137 ! abnormal gastric surface mucous cell morphology

[Term]
id: MP:0004139
name: abnormal gastric parietal cell morphology
def: "any structural anomaly of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal parietal cell morphology" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0004140
name: abnormal gastric chief cell morphology
def: "any structural anomaly of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal chief cell morphology" BROAD []
synonym: "abnormal chief cell of stomach morphology" EXACT []
synonym: "abnormal gastric zymogenic cell morphology" EXACT []
synonym: "abnormal peptic cell morphology" EXACT []
synonym: "abnormal zymogenic cell of stomach morphology" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0004141
name: abnormal enteroendocrine cell morphology
def: "any structural anomaly of the various hormone- or neurotransmitter-secreting epithelial cells present throughout the mucosa of the digestive tract" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal intestinal L cell morphology" NARROW []
synonym: "abnormal intestinal S cell morphology" NARROW []
synonym: "abnormal intestinal secretin cell morphology" NARROW []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0004142
name: abnormal muscle tone
def: "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [MGI:hdene]
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0004143
name: muscle hypertonia
def: "increased muscle tension resulting in stiffness of the muscles in the resting state" [MGI:hdene]
synonym: "muscle hypertonicity" EXACT []
synonym: "muscle hypertonus" EXACT []
synonym: "muscle spasticity" EXACT []
is_a: MP:0004142 ! abnormal muscle tone

[Term]
id: MP:0004144
name: hypotonia
def: "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [MGI:hdene]
synonym: "hypotonicity" EXACT []
synonym: "hypotonus" EXACT []
is_a: MP:0004142 ! abnormal muscle tone

[Term]
id: MP:0004145
name: abnormal muscle electrophysiology
def: "any functional anomaly of the musculature as it relates to electrical phenomena" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal muscle electrical activity" EXACT []
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0004146
name: absent M line
def: "missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent M band" EXACT []
synonym: "absent M disc" EXACT []
synonym: "absent M disk" EXACT []
synonym: "absent M lines" EXACT []
synonym: "absent mesophragma" EXACT []
is_a: MP:0004094 ! abnormal M line morphology

[Term]
id: MP:0004147
name: increased porphyrin level
def: "elevated concentration of porphyrins or protoporphyrins" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011989 ! abnormal porphyrin level

[Term]
id: MP:0004148
name: increased compact bone thickness
def: "thicker than normal superficial layer of compact bone" [MGI:brs]
synonym: "increased cortical bone thickness" EXACT []
is_a: MP:0000134 ! abnormal compact bone thickness

[Term]
id: MP:0004149
name: increased bone strength
def: "increased ability of bone to endure the application of force without yielding or breaking" [MGI:brs]
is_a: MP:0001542 ! abnormal bone strength

[Term]
id: MP:0004150
name: absent caveolae
def: "absence of the small pockets, vesicles, caves, or recesses communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003950 ! abnormal plasma membrane morphology

[Term]
id: MP:0004151
name: decreased circulating iron level
def: "less than the normal concentration of iron in the blood" [https://orcid.org/0000-0002-6490-7723]
comment: Serum iron measures the total amount of iron in the blood, nearly all of which is bound to transferrin.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased serum iron level" NARROW []
synonym: "hypoferraemia" EXACT []
synonym: "hypoferremia" EXACT []
synonym: "reduced circulating iron level" EXACT []
synonym: "serum iron deficiency" NARROW []
is_a: MP:0004152 ! abnormal circulating iron level
is_a: MP:0014542 ! decreased iron level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0004152
name: abnormal circulating iron level
def: "anomalous blood concentration of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [ISBN:0-683-40008-8]
comment: Serum iron measures the total amount of iron in the blood, nearly all of which is bound to transferrin.
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0006357 ! abnormal circulating mineral level

[Term]
id: MP:0004153
name: increased renal tubule apoptosis
def: "increase in the number of renal tubule cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011368 ! increased kidney apoptosis

[Term]
id: MP:0004154
name: renal tubular necrosis
def: "morphological changes resulting from pathological death of renal tubular tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "necrotic renal tubule" EXACT []
synonym: "necrotic renal tubules" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology
is_a: MP:0003946 ! renal necrosis

[Term]
id: MP:0004155
name: decreased susceptibility to induced pancreatitis
def: "reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation" [https://orcid.org/0000-0001-7973-5445]
synonym: "increased resistance to induced pancreatitis" RELATED []
is_a: MP:0002693 ! abnormal pancreas physiology

[Term]
id: MP:0004156
name: abnormal QT variability
def: "anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal QTVI" EXACT []
is_a: MP:0003899 ! abnormal QT interval

[Term]
id: MP:0004157
name: interrupted aortic arch
def: "complete discontinuation between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [https://orcid.org/0009-0005-7755-8314, https://www.cincinnatichildrens.org/health/i/iaa]
subset: CvDC_Terms
synonym: "IAA" EXACT []
xref: Fyler:1250
is_a: MP:0004113 ! abnormal aortic arch morphology
is_a: MP:0010544 ! interrupted aorta

[Term]
id: MP:0004158
name: right aortic arch
def: "the aortic arch lies to the right of the trachea and esophagus; results from persistence of the entire right dorsal arch and involution of a segment of the left arch" [https://orcid.org/0009-0005-7755-8314]
subset: CvDC_Terms
synonym: "right sided aortic arch" EXACT []
synonym: "right-sided aortic arch" EXACT []
xref: Fyler:2720
is_a: MP:0004113 ! abnormal aortic arch morphology

[Term]
id: MP:0004159
name: double aortic arch
def: "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body" [https://orcid.org/0009-0005-7755-8314]
subset: CvDC_Terms
synonym: "double-sided aortic arch" EXACT []
xref: Fyler:2761
is_a: MP:0010466 ! vascular ring

[Term]
id: MP:0004160
name: retroesophageal right subclavian artery
def: "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [https://orcid.org/0009-0005-7755-8314]
synonym: "arteria subclavia lusoria" EXACT []
synonym: "retro-esophageal right subclavian artery" EXACT []
synonym: "retro-oesophageal right subclavian artery" EXACT []
is_a: MP:0010465 ! aberrant origin of the right subclavian artery

[Term]
id: MP:0004161
name: cervical aortic arch
def: "aortic arch is located above the level of the clavicle" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0004113 ! abnormal aortic arch morphology

[Term]
id: MP:0004162
name: abnormal mammillary body morphology
def: "any structural anomaly of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000830 ! abnormal diencephalon morphology

[Term]
id: MP:0004163
name: abnormal adenohypophysis morphology
def: "any structural anomaly of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal adenophysis morphology" EXACT []
synonym: "abnormal anterior pituitary lobe" EXACT []
synonym: "abnormal pituitary anterior lobe" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology

[Term]
id: MP:0004164
name: abnormal neurohypophysis morphology
def: "any structural anomaly of the posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormone" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal infundibular process morphology" EXACT []
synonym: "abnormal neural lobe of pituitary gland morphology" EXACT []
synonym: "abnormal neural lobe of pituitary morphology" EXACT []
synonym: "abnormal neurophysis morphology" EXACT []
synonym: "abnormal pituitary posterior lobe" RELATED []
synonym: "abnormal posterior lobe of pituitary gland morphology" EXACT []
synonym: "abnormal posterior lobe of pituitary morphology" EXACT []
synonym: "abnormal posterior pituitary morphology" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology
is_a: MP:0013563 ! abnormal secretory circumventricular organ morphology

[Term]
id: MP:0004165
name: abnormal lateral geniculate nucleus morphology
def: "any structural anomaly of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [ISBN:0-683-40008-8]
synonym: "abnormal LGN morphology" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0004166
name: abnormal limbic system morphology
def: "any structural anomaly of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system" [https://orcid.org/0000-0003-3691-0324, PMID:2181500]
is_a: MP:0000783 ! abnormal forebrain morphology

[Term]
id: MP:0004167
name: abnormal cingulate gyrus morphology
def: "any structural anomaly of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal callosal gyrus morphology" EXACT []
synonym: "abnormal falciform lobe" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0020749 ! abnormal cingulate cortex morphology

[Term]
id: MP:0004168
name: abnormal parahippocampal gyrus morphology
def: "any structural anomaly of the ridge in the cerebral cortex that contains the olfactory cortex and that plays a role in the formation of topographical memory" [ISBN:0-683-40008-8]
is_a: MP:0000801 ! abnormal temporal lobe morphology
is_a: MP:0004169 ! abnormal fornicate gyrus morphology

[Term]
id: MP:0004169
name: abnormal fornicate gyrus morphology
def: "any structural anomaly of the horseshoe-shaped gyrus of the cerebral cortex that consists of the cingulate gyrus and the parahippocampal gyrus" [ISBN:0-683-40008-8]
synonym: "abnormal limbic lobe morphology" EXACT []
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0004170
name: abnormal orbitofrontal cortex morphology
def: "any structural anomaly of the region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0000798 ! abnormal frontal lobe morphology
is_a: MP:0004166 ! abnormal limbic system morphology

[Term]
id: MP:0004171
name: abnormal pallium development
def: "anomaly in the progression of the formation of the roof region of the telencephalon" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0004172
name: abnormal subpallium development
def: "anomaly in the progression of the formation of the base region of the telencephalon" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0004173
name: abnormal intervertebral disk morphology
def: "any structural anomaly of the cartilaginous and gelatinous structure found between vertebrae" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal intervertebral disc morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0004703 ! abnormal vertebral column morphology
is_a: MP:0030877 ! abnormal symphysis morphology

[Term]
id: MP:0004174
name: abnormal spine curvature
def: "deviation from the typical S-shape of the spine" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0004703 ! abnormal vertebral column morphology

[Term]
id: MP:0004175
name: telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels" [https://orcid.org/0009-0005-7755-8314]
synonym: "telangiectases" EXACT [https://www.ncbi.nlm.nih.gov/medgen/21088]
synonym: "telangiectasias" EXACT []
synonym: "telangiectasis" EXACT []
is_a: MP:0001613 ! abnormal vasodilation

[Term]
id: MP:0004176
name: ear telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the ear" [https://orcid.org/0009-0005-7755-8314]
synonym: "ear telangiectases" EXACT []
synonym: "ear telangiectasias" EXACT []
synonym: "ear telangiectasis" EXACT []
is_a: MP:0002102 ! abnormal ear morphology
is_a: MP:0004175 ! telangiectasia

[Term]
id: MP:0004177
name: tail telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the tail" [https://orcid.org/0009-0005-7755-8314]
synonym: "tail telangiectases" EXACT []
synonym: "tail telangiectasias" EXACT []
synonym: "tail telangiectasis" EXACT []
is_a: MP:0004175 ! telangiectasia

[Term]
id: MP:0004178
name: neck telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the neck" [https://orcid.org/0009-0005-7755-8314]
synonym: "neck telangiectases" EXACT []
synonym: "neck telangiectasias" EXACT []
synonym: "neck telangiectasis" EXACT []
is_a: MP:0004175 ! telangiectasia

[Term]
id: MP:0004179
name: transmission ratio distortion
def: "the frequency that an allele or haplotype in the offspring of an organism deviates from expected Mendelian ratios" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "nonrandom segregation ratio" EXACT []
is_a: MP:0001929 ! abnormal gametogenesis

[Term]
id: MP:0004180
name: failure of initiation of embryo turning
def: "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage" [https://orcid.org/0009-0005-7755-8314]
comment: In mouse, this event occurs at E8.5-E9.5.
is_a: MP:0001700 ! abnormal embryo turning

[Term]
id: MP:0004181
name: abnormal carotid artery morphology
def: "any structural anomaly of the bilaterally paired branched arteries that deliver oxygenated nutrient filled blood from the heart to the head, neck, and brain; of the two common carotid arteries, which extend headward on each side of the anterior neck, the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery near the top of the thyroid" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0004182
name: abnormal spermiation
def: "anomaly in the process by which mature spermatids are released from the supporting Sertoli cells into the lumen of seminiferous tubules prior to their passage to the epididymis" [https://orcid.org/0000-0002-6490-7723, PMID:21866274]
is_a: MP:0001932 ! abnormal spermiogenesis

[Term]
id: MP:0004183
name: abnormal sympathetic nervous system physiology
def: "any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006276 ! abnormal autonomic nervous system physiology

[Term]
id: MP:0004184
name: abnormal baroreceptor physiology
def: "any functional anomaly of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal baroreflex function" EXACT []
synonym: "abnormal pressoreceptor physiology" EXACT []
is_a: MP:0004183 ! abnormal sympathetic nervous system physiology

[Term]
id: MP:0004185
name: abnormal adipocyte glucose uptake
def: "anomaly in the ability of adipocytes to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fat cell glucose uptake" EXACT []
is_a: MP:0003925 ! abnormal cellular glucose uptake
is_a: MP:0005666 ! abnormal adipose tissue physiology

[Term]
id: MP:0004186
name: abnormal area postrema morphology
def: "any structural anomaly of the small, elevated area in the lateral wall of the inferior recess of the fourth ventricle, involved in the control of cardiorespiratory physiology; in addition, the area postrema is the location of the chemotoxic trigger zone at which emesis (vomiting) is induced by various toxins in the blood stream and that affect the hypothalamus to induce taste aversion" [http://neuroscience.uth.tmc.edu/s4/chapter01.html, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000828 ! abnormal fourth ventricle morphology
is_a: MP:0013564 ! abnormal sensory circumventricular organ morphology

[Term]
id: MP:0004187
name: cardia bifida
def: "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000270 ! abnormal heart tube morphology

[Term]
id: MP:0004188
name: delayed embryo turning
def: "completion of axial rotation occurs later than in controls but is eventually completed" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001700 ! abnormal embryo turning

[Term]
id: MP:0004189
name: abnormal alveolar process morphology
def: "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal alveolar body morphology" EXACT []
synonym: "abnormal alveolar bone morphology" EXACT []
synonym: "abnormal alveolar ridge morphology" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
is_a: MP:0030131 ! abnormal periodontium morphology

[Term]
id: MP:0004190
name: abnormal direction of embryo turning
def: "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage; clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6]
comment: In mouse, this event occurs at E8.5-E9.5.
is_a: MP:0001700 ! abnormal embryo turning

[Term]
id: MP:0004191
name: neuronal intranuclear inclusions
def: "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington's disease" [MGI:acv]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0004192
name: abnormal kidney pyramid morphology
def: "any structural anomaly of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal malpighian pyramid morphology" EXACT []
synonym: "abnormal medullary pyramid morphology" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology

[Term]
id: MP:0004193
name: abnormal kidney papilla morphology
def: "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004192 ! abnormal kidney pyramid morphology
is_a: MP:0004194 ! abnormal kidney pelvis morphology

[Term]
id: MP:0004194
name: abnormal kidney pelvis morphology
def: "any structural anomaly of the area at the center of the kidney formed by convergence of the major calices where urine collects and is funneled into the ureter" [https://orcid.org/0000-0003-4606-0597, url:https\://www.cancer.gov/publications/dictionaries/cancer-terms/def/renal-pelvis]
synonym: "abnormal pelvis of ureter morphology" EXACT []
synonym: "abnormal pyelum morphology" RELATED []
synonym: "abnormal renal pelvis morphology" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0004195
name: abnormal kidney calyx morphology
def: "any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal calyx morphology" EXACT []
synonym: "abnormal kidney calicies morphology" RELATED []
synonym: "abnormal kidney calix morphology" EXACT []
synonym: "abnormal renal calix morphology" RELATED []
synonym: "abnormal renal calyx morphology" EXACT []
xref: MA:0000369
is_a: MP:0004194 ! abnormal kidney pelvis morphology

[Term]
id: MP:0004196
name: abnormal prenatal growth/weight/body size
def: "limited or accelerated growth or development apparent before birth" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0004197
name: abnormal fetal growth/weight/body size
def: "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal foetal growth/weight/body size" EXACT []
is_a: MP:0004196 ! abnormal prenatal growth/weight/body size

[Term]
id: MP:0004198
name: abnormal fetal size
def: "anomalous proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal foetal size" EXACT []
is_a: MP:0004197 ! abnormal fetal growth/weight/body size
is_a: MP:0010866 ! abnormal prenatal body size

[Term]
id: MP:0004199
name: increased fetal size
def: "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged fetal size" EXACT []
synonym: "enlarged foetal size" EXACT []
synonym: "increased foetal size" EXACT []
is_a: MP:0004198 ! abnormal fetal size

[Term]
id: MP:0004200
name: decreased fetal size
def: "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased foetal size" EXACT []
synonym: "reduced fetal size" EXACT []
synonym: "reduced foetal size" EXACT []
is_a: MP:0004198 ! abnormal fetal size

[Term]
id: MP:0004201
name: fetal growth retardation
def: "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "foetal growth retardation" EXACT []
is_a: MP:0004197 ! abnormal fetal growth/weight/body size
is_a: MP:0010865 ! prenatal growth retardation

[Term]
id: MP:0004202
name: pulmonary hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lung, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic lung" EXACT []
synonym: "lung hyperplasia" EXACT []
is_a: MP:0004882 ! enlarged lung

[Term]
id: MP:0004203
name: abnormal cranial flexure morphology
def: "any structural anomaly or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cephalic flexure morphology" EXACT []
synonym: "abnormal cerebral flexure morphology" EXACT []
synonym: "abnormal mesencephalic flexure morphology" EXACT []
synonym: "abnormal midbrain flexure morphology" EXACT []
is_a: MP:0003864 ! abnormal midbrain development

[Term]
id: MP:0004204
name: absent stapes
def: "absence of the smallest and innermost of the three auditory ossicles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000040 ! absent middle ear ossicles
is_a: MP:0005107 ! abnormal stapes morphology

[Term]
id: MP:0004205
name: absent hyoid bone
def: "absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lingual bone" EXACT []
synonym: "absent tongue bone" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004206
name: abnormal dermomyotome development
def: "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal dermamyotome development" EXACT []
is_a: MP:0000737 ! abnormal myotome development

[Term]
id: MP:0004207
name: increased squamous cell carcinoma incidence
def: "higher than normal incidence of a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk]
synonym: "SCC" RELATED []
synonym: "squamous cell carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence

[Term]
id: MP:0004208
name: increased basal cell carcinoma incidence
def: "greater than the expected number of a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis, occurring in a specific population in a given time period" [MGI:rbabiuk]
synonym: "skin basal cell carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0004209
name: abnormal sweet taste sensitivity
def: "changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001986 ! abnormal taste sensitivity

[Term]
id: MP:0004210
name: abnormal bitter taste sensitivity
def: "changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001986 ! abnormal taste sensitivity

[Term]
id: MP:0004211
name: abnormal sour taste sensitivity
def: "changes in the ability to perceive a particular flavor or suggestion of something sour by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001986 ! abnormal taste sensitivity

[Term]
id: MP:0004212
name: abnormal salty taste sensitivity
def: "changes in the ability to perceive a particular flavor or suggestion of something salty by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001986 ! abnormal taste sensitivity

[Term]
id: MP:0004213
name: abnormal umami taste sensitivity
def: "changes in the ability to perceive a particular flavor or suggestion of something umami (savory) by the chemoreceptors of the gustatory system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001986 ! abnormal taste sensitivity

[Term]
id: MP:0004214
name: abnormal long bone diaphysis morphology
def: "any structural anomaly of the main or mid section (shaft) of a long bone" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal long bone shaft morphology" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0004215
name: abnormal myocardial fiber physiology
def: "anomaly in the function of the terminally differentiated, non-proliferative, multinucleated muscle cells of the heart" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal adult cardiomyocyte physiology" EXACT []
synonym: "abnormal cardiac muscle cell physiology" EXACT []
synonym: "abnormal cardiac myocyte physiology" EXACT []
synonym: "abnormal myocardial fibre physiology" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0004216
name: salt-resistant hypertension
def: "sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000231 ! hypertension

[Term]
id: MP:0004217
name: salt-sensitive hypertension
def: "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [https://orcid.org/0000-0003-3691-0324]
synonym: "salt-induced hypertension" EXACT []
is_a: MP:0000231 ! hypertension

[Term]
id: MP:0004218
name: meiotic nondisjunction during M1 phase
def: "abnormal separation of pairs of homologous chromosomes during anaphase of the first meiotic division such that each daughter cell receives one set of paired chromosomes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009566 ! meiotic nondisjunction

[Term]
id: MP:0004219
name: meiotic nondisjunction during M2 phase
def: "abnormal separation of chromosomes during anaphase of the second meiotic division such that one complete chromosome goes to each daughter cell" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009566 ! meiotic nondisjunction

[Term]
id: MP:0004220
name: abnormal peripheral nervous system regeneration
def: "anomaly in the renewal, repair, and/or regrowth of peripheral nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal PNS regeneration" EXACT []
is_a: MP:0004858 ! abnormal nervous system regeneration

[Term]
id: MP:0004221
name: abnormal iridocorneal angle
def: "any structural anomaly of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [https://orcid.org/0000-0002-6490-7723, PMID:8652890]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal angle of the iris" EXACT []
synonym: "abnormal anterior chamber angle" EXACT []
synonym: "abnormal filtration angle" EXACT []
is_a: MP:0005198 ! abnormal aqueous drainage system morphology

[Term]
id: MP:0004222
name: iris synechia
def: "an adhesion (synechia) of the iris to the cornea or lens of the eye that may develop from glaucoma, cataracts, uveitis, or keratitis or as a complication of surgery or trauma to the eye; synechiae may prevent or impede flow of aqueous fluid between the anterior and posterior chambers of the eye, resulting in angle closure glaucoma" [https://orcid.org/0000-0002-6490-7723]
synonym: "iris synechiae" EXACT []
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0004223
name: hypoplastic trabecular meshwork
def: "decrease in the number of normal cells in normal arrangement in the trabecular meshwork of the eye, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723, MESH:A09.371.060.932]
synonym: "trabecular meshwork hypoplasia" EXACT []
is_a: MP:0005203 ! abnormal trabecular meshwork morphology

[Term]
id: MP:0004224
name: absent trabecular meshwork
def: "absence of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [https://orcid.org/0000-0002-6490-7723, MESH:A09.371.060.932]
is_a: MP:0005203 ! abnormal trabecular meshwork morphology

[Term]
id: MP:0004225
name: patent cardiac foramen ovale
def: "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [https://orcid.org/0000-0002-6490-7723]
subset: CvDC_Terms
synonym: "persistent cardiac foramen ovale" EXACT []
synonym: "PFO" EXACT []
xref: Fyler:2020
is_a: MP:0000282 ! abnormal interatrial septum morphology

[Term]
id: MP:0004226
name: absent Schlemm's canal
def: "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0005204 ! abnormal canal of Schlemm morphology

[Term]
id: MP:0004227
name: increased cellular sensitivity to ionizing radiation
def: "increased incidence of cell death following exposure to ionizing radiation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to ionizing radiation" EXACT []
synonym: "increased cellular susceptibility to ionizing radiation" EXACT []
is_a: MP:0008943 ! increased sensitivity to induced cell death

[Term]
id: MP:0004228
name: decreased cellular sensitivity to ionizing radiation
def: "decreased incidence of cell death following exposure to ionizing radiation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular susceptibility to ionizing radiation" EXACT []
synonym: "increased cellular resistance to ionizing radiation" EXACT []
synonym: "reduced cellular sensitivity to ionizing radiation" EXACT []
is_a: MP:0008944 ! decreased sensitivity to induced cell death

[Term]
id: MP:0004229
name: abnormal embryonic erythropoiesis
def: "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal embryonic erythrocyte development" EXACT []
synonym: "abnormal primitive erythropoiesis" EXACT []
is_a: MP:0003396 ! abnormal embryonic hematopoiesis
is_a: MP:0004230 ! abnormal embryonic erythrocyte morphology

[Term]
id: MP:0004230
name: abnormal embryonic erythrocyte morphology
def: "any structural anomaly of the embryonic blood cells that carry oxygen; embryonic erythrocytes arise from yolk sac blood islands and express different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes, and can enucleate in circulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal primary erythrocyte morphology" RELATED []
synonym: "abnormal primitive erythroblast morphology" EXACT []
synonym: "abnormal primitive erythrocyte morphology" EXACT []
synonym: "abnormal primitive erythroid cell morphology" EXACT []
synonym: "abnormal primitive red blood cell morphology" EXACT []
xref: CL:0002355
is_a: MP:0013659 ! abnormal erythroid lineage cell morphology

[Term]
id: MP:0004231
name: abnormal calcium ion homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [https://orcid.org/0000-0003-3691-0324]
xref: GO:0006874
is_a: MP:0001765 ! abnormal ion homeostasis

[Term]
id: MP:0004232
name: decreased muscle weight
def: "less than average muscle weight" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced muscle weight" EXACT []
is_a: MP:0004233 ! abnormal muscle weight

[Term]
id: MP:0004233
name: abnormal muscle weight
def: "any anomaly in the average muscle weight" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002108 ! abnormal muscle morphology

[Term]
id: MP:0004234
name: abnormal masticatory muscle morphology
def: "any structural anomaly of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles" [https://orcid.org/0000-0002-6490-7723, MESH:A02.633.567.600]
is_a: MP:0030039 ! abnormal facial muscle morphology

[Term]
id: MP:0004235
name: abnormal masseter muscle morphology
def: "any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [https://orcid.org/0000-0002-6490-7723, MESH:A02.633.567.600.500]
is_a: MP:0004234 ! abnormal masticatory muscle morphology

[Term]
id: MP:0004236
name: absent masseter muscle
def: "absence of the masticatory muscle of posterior cheek" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004235 ! abnormal masseter muscle morphology

[Term]
id: MP:0004237
name: abnormal pterygoid muscle morphology
def: "any structural anomaly of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle; the action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side" [https://orcid.org/0000-0002-6490-7723, MESH:A02.633.567.600.700]
is_a: MP:0004234 ! abnormal masticatory muscle morphology

[Term]
id: MP:0004238
name: absent pterygoid muscle
def: "absence of either the internal or external or of both pterygoid muscles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004237 ! abnormal pterygoid muscle morphology

[Term]
id: MP:0004239
name: abnormal temporalis muscle morphology
def: "any structural anomaly of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible" [https://orcid.org/0000-0002-6490-7723, MESH:A02.633.567.600.850]
synonym: "abnormal musculus temporalis" EXACT []
synonym: "abnormal temporal muscle" EXACT [MESH:A02.633.567.600.850]
synonym: "abnormal temporalis" EXACT []
is_a: MP:0004234 ! abnormal masticatory muscle morphology

[Term]
id: MP:0004240
name: absent temporalis muscle
def: "absence of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible" [https://orcid.org/0000-0002-6490-7723, MESH:A02.633.567.600.850]
synonym: "absent musculus temporalis" EXACT []
synonym: "absent temporal muscle" EXACT []
synonym: "absent temporalis" EXACT []
is_a: MP:0004239 ! abnormal temporalis muscle morphology

[Term]
id: MP:0004241
name: acantholysis
def: "separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease" [MESH:C17.800.865.070]
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0004242
name: abnormal plasmacytoid dendritic cell morphology
def: "any structural anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [https://orcid.org/0000-0003-3691-0324, PMID:10449155, PMID:15596797]
synonym: "abnormal DC2" EXACT []
synonym: "abnormal lymphoid dendritic cell" EXACT []
synonym: "abnormal pDC" EXACT []
synonym: "abnormal plasmacytoid monocytes" EXACT []
synonym: "abnormal plasmacytoid T cell" EXACT []
synonym: "abnormal T-associated plasma cells" EXACT []
is_a: MP:0005461 ! abnormal dendritic cell morphology

[Term]
id: MP:0004243
name: abnormal motor nerve collateral sprouting
def: "aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal motor nerve nodal sprouting" NARROW []
synonym: "abnormal motor nerve terminal sprouting" NARROW []
is_a: MP:0010726 ! abnormal collateral sprouting

[Term]
id: MP:0004244
name: abnormal miscarriage rate
def: "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal spontaneous abortion rate" EXACT []
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0004245
name: genital hemorrhage
def: "bleeding into the genitals" [https://orcid.org/0000-0002-6490-7723]
synonym: "genital haemorrhage" EXACT []
is_a: MP:0001914 ! hemorrhage
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0004246
name: abnormal extensor digitorum longus morphology
def: "any structural anomaly of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal EDL morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0021206 ! abnormal limb muscle morphology

[Term]
id: MP:0004247
name: small pancreas
def: "decrease of the size of the pancreas compared to controls" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased pancreas size" EXACT []
synonym: "reduced pancreas size" EXACT []
is_a: MP:0009106 ! abnormal pancreas size

[Term]
id: MP:0004248
name: abnormal epaxial muscle morphology
def: "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0004249
name: abnormal crista ampullaris morphology
def: "any structural anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cristae morphology" EXACT []
xref: MA:0002771
is_a: MP:0008488 ! abnormal semicircular canal ampulla morphology

[Term]
id: MP:0004250
name: tau protein deposits
def: "formation of self-assembled aggregates of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [https://orcid.org/0000-0003-3691-0324, PMID:38930877]
is_a: MP:0014062 ! nervous system inclusion bodies
is_a: MP:0021002 ! brain lesion

[Term]
id: MP:0004251
name: failure of heart looping
def: "failure of the primitive heart tube to loop asymmetrically during early development" [GO:0001947]
subset: IMPC_Prenatal
synonym: "failure of cardiac looping" EXACT []
synonym: "failure of looping morphogenesis" RELATED []
is_a: MP:0000269 ! abnormal heart looping

[Term]
id: MP:0004252
name: abnormal direction of heart looping
def: "deviation from the characteristic rightward direction of looping of the primitive heart tube; frequently seen in heterotaxy syndromes" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal direction of cardiac looping" EXACT []
synonym: "abnormal direction of looping morphogenesis" RELATED []
is_a: MP:0000269 ! abnormal heart looping

[Term]
id: MP:0004253
name: bifid atrial appendage
def: "a cardiac anomaly whereby the left or right atrial appendage is cleaved, forming two separate pouches connected by a thin strand of muscular tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010489 ! abnormal heart atrium auricular region morphology

[Term]
id: MP:0004254
name: cerebral amyloid angiopathy
def: "a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [MGI:acv]
is_a: MP:0000604 ! amyloidosis
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0004255
name: abnormal spongiotrophoblast layer morphology
def: "any structural anomaly of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [ISBN-10:0521851653]
is_a: MP:0005031 ! abnormal trophoblast layer morphology
is_a: MP:0008957 ! abnormal placenta junctional zone morphology

[Term]
id: MP:0004256
name: abnormal maternal decidual layer morphology
def: "any structural anomaly of the maternal uterine-derived portion of the placenta" [PMID:11433360]
is_a: MP:0001120 ! abnormal uterus morphology
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0004257
name: abnormal placenta weight
def: "any change in the weight of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004258 ! abnormal placenta size

[Term]
id: MP:0004258
name: abnormal placenta size
def: "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0004259
name: small placenta
def: "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased placenta size" EXACT []
synonym: "reduced size of placenta" EXACT []
is_a: MP:0004258 ! abnormal placenta size

[Term]
id: MP:0004260
name: enlarged placenta
def: "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased size of placenta" EXACT []
synonym: "large placenta" RELATED []
synonym: "placentomegaly" EXACT []
is_a: MP:0004258 ! abnormal placenta size

[Term]
id: MP:0004261
name: abnormal embryonic neuroepithelium morphology
def: "any structural anomaly of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [https://orcid.org/0009-0005-7755-8314, ISBN:0838580343]
synonym: "abnormal embryonic neuroectoderm morphology" EXACT []
synonym: "abnormal neural tube neuroepithelium morphology" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0004262
name: abnormal physical strength
def: "altered ability of an organism to exert force on physical objects or of the body to support its load" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement

[Term]
id: MP:0004263
name: abnormal limb posture
def: "atypical intentionally or habitually assumed position of the limbs compared to the normal carriage of the body" [https://orcid.org/0000-0003-3691-0324]
comment: This term should not be used to describe abnormal limb placement on the body (congenital or trauma induced).
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0004264
name: abnormal extraembryonic tissue physiology
def: "any functional anomaly of the membranes involved with embryonic protection and nutrition" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005380 ! embryo phenotype

[Term]
id: MP:0004265
name: abnormal placental transport
def: "anomaly in the conveyance of metabolic products and nutrients across the placenta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010038 ! abnormal placenta physiology

[Term]
id: MP:0004266
name: pale placenta
def: "placenta lacking normal reddish coloration, often refers to bloodless condition" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0004267
name: abnormal optic tract morphology
def: "any structural anomaly of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal tractus opticus morphology" EXACT []
is_a: MP:0000778 ! abnormal nervous system tract morphology
is_a: MP:0008026 ! abnormal brain white matter morphology

[Term]
id: MP:0004268
name: abnormal optic stalk morphology
def: "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3]
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0004269
name: abnormal optic cup morphology
def: "any structural anomaly of double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal eye cup morphology" EXACT []
synonym: "abnormal eyecup morphology" EXACT []
synonym: "abnormal ocular cup morphology" EXACT []
synonym: "abnormal ophtalmic cup morphology" EXACT []
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0004270
name: analgesia
def: "inability to sense pain" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001968 ! abnormal touch/ nociception

[Term]
id: MP:0004272
name: abnormal basement membrane morphology
def: "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8, MESH:A10.272.220]
comment: Note: Basal lamina and lamina reticularis (or of two basal laminae) compose the basement membrane. Thus, in strict sense, the term basement membrane is different from and should not be confused with basal lamina.
synonym: "abnormal basement lamina morphology" EXACT []
synonym: "basement membrane dysplasia" NARROW []
is_a: MP:0013258 ! abnormal extracellular matrix morphology

[Term]
id: MP:0004273
name: abnormal basal lamina morphology
def: "any structural anomaly of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8]
comment: Note: Basal lamina and lamina reticularis (or of two basal laminae) compose the basement membrane. Thus, in strict sense, the term basement membrane is different from and should not be confused with basal lamina.
is_a: MP:0004272 ! abnormal basement membrane morphology

[Term]
id: MP:0004274
name: abnormal embryonic/fetal subventricular zone morphology
def: "any structural anomaly of the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [https://orcid.org/0000-0003-3691-0324, PMID:12637172]
synonym: "abnormal embryonic subventricular zone" EXACT []
synonym: "abnormal embryonic/foetal subventricular zone morphology" EXACT []
synonym: "abnormal subependymal layer" BROAD []
synonym: "abnormal subependymal plate" BROAD []
synonym: "abnormal subependymal zone" BROAD []
synonym: "abnormal subventricular zone" BROAD []
synonym: "abnormal SVZ" BROAD []
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0004275
name: abnormal postnatal subventricular zone morphology
def: "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [https://orcid.org/0000-0003-3691-0324, PMID:12637172]
synonym: "abnormal adult SVZ" EXACT []
synonym: "abnormal SEZ morphology" EXACT []
synonym: "abnormal subependymal layer" BROAD []
synonym: "abnormal subependymal plate" BROAD []
synonym: "abnormal subependymal zone" BROAD []
synonym: "abnormal subventricular zone" BROAD []
synonym: "abnormal SVZ" BROAD []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0004276
name: abnormal medial ganglionic eminence morphology
def: "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [https://orcid.org/0000-0003-3691-0324, PMID:12637172]
synonym: "abnormal MGE" EXACT []
is_a: MP:0004274 ! abnormal embryonic/fetal subventricular zone morphology

[Term]
id: MP:0004277
name: abnormal lateral ganglionic eminence morphology
def: "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [https://orcid.org/0000-0003-3691-0324, PMID:12637172]
synonym: "abnormal LGE" EXACT []
is_a: MP:0004274 ! abnormal embryonic/fetal subventricular zone morphology

[Term]
id: MP:0004278
name: abnormal caudal ganglionic eminence morphology
def: "any structural anomaly of the caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle" [https://orcid.org/0000-0003-3691-0324, PMID:12637172]
synonym: "abnormal CGE" EXACT []
is_a: MP:0004274 ! abnormal embryonic/fetal subventricular zone morphology

[Term]
id: MP:0004279
name: abnormal rostral migratory stream morphology
def: "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002739 ! abnormal olfactory bulb development

[Term]
id: MP:0004280
name: abnormal oculomotor nucleus morphology
def: "any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000897 ! abnormal midbrain morphology

[Term]
id: MP:0004281
name: abnormal hypoglossal nucleus morphology
def: "any structural anomaly of the group of motor neurons throughout most of the length of the medulla oblongata that give rise to the motor fibers of the hypoglossal nerve" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000846 ! abnormal medulla oblongata morphology

[Term]
id: MP:0004282
name: retrognathia
def: "abnormal posterior-shifted positioning of the upper or lower jaw relative to the facial skeleton and soft tissues; a type of malocclusion, that is, misalignment of the teeth caused by abnormal positioning of the jaws; the mandible is more frequently affected than the maxilla" [https://orcid.org/0000-0002-6490-7723]
synonym: "jaw retroposition" EXACT []
synonym: "receding jaw" EXACT []
synonym: "recessed jaw" EXACT []
synonym: "retrognathism" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology

[Term]
id: MP:0004283
name: absent cornea endothelium
def: "absence of the single layer of large flattened cells that cover the surface of the cornea" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent corneal endothelium" EXACT []
is_a: MP:0005301 ! abnormal cornea endothelium morphology

[Term]
id: MP:0004284
name: abnormal Descemet membrane morphology
def: "any structural anomaly in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [https://orcid.org/0000-0002-6490-7723, MESH:A09.371.060.217.271]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal Descemet's membrane" EXACT []
synonym: "abnormal Duddell membrane" EXACT []
synonym: "abnormal entocornea" EXACT []
synonym: "abnormal hyaloid membrane" EXACT []
synonym: "abnormal lamina elastica posterior" EXACT []
synonym: "abnormal lamina limitans posterior corneae" EXACT []
synonym: "abnormal membrana hyaloidea" EXACT []
synonym: "abnormal membrana vitrea" EXACT []
synonym: "abnormal posterior elastic layer" EXACT []
synonym: "abnormal posterior limiting lamina of cornea" EXACT []
synonym: "abnormal posterior limiting layer of cornea" EXACT []
synonym: "abnormal tunica vitrea" EXACT []
synonym: "abnormal vitreous membrane" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0004285
name: absent Descemet membrane
def: "absence of the transparent homogeneous acellular layer normally found between the substantia propria and the endothelial layer of the cornea" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004284 ! abnormal Descemet membrane morphology

[Term]
id: MP:0004286
name: abnormal internal auditory canal morphology
def: "any structural anomaly in the canal beginning at the opening of the internal acoustic meatus in the posterior cranial fossa, passing laterally through the petrous portion of the temporal bone to end at the fundus, where a thin plate of bone separates it from the vestibule; it gives passage to the facial and vestibulocochlear nerves together with the labyrinthine artery and veins" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal acoustic meatus morphology" EXACT []
synonym: "abnormal internal auditory meatus morphology" EXACT []
synonym: "abnormal meatus auditorius internus morphology" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0030309 ! abnormal posterior cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology

[Term]
id: MP:0004287
name: abnormal spiral limbus morphology
def: "any structural anomaly in the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal limbus laminae spiralis osseae" EXACT []
synonym: "abnormal limbus spiralis" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0004288
name: abnormal spiral ligament morphology
def: "any structural anomaly in the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal crista spiralis" EXACT []
synonym: "abnormal ligamentum spirale cochleae" EXACT []
synonym: "abnormal ligamentum spirale ductus cochlearis" EXACT []
synonym: "abnormal spiral crest" EXACT []
synonym: "abnormal spiral ligament of cochlea" EXACT []
synonym: "abnormal spiral ligament of cochlear duct" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology
is_a: MP:0005504 ! abnormal ligament morphology

[Term]
id: MP:0004289
name: abnormal bony labyrinth
def: "any structural anomaly in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal labyrinthus osseus" EXACT []
synonym: "abnormal osseous labyrinth" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology

[Term]
id: MP:0004290
name: abnormal stapes footplate morphology
def: "any structural anomaly in the flat portion of the stapes that fits in the oval window" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal base of stapes morphology" EXACT []
synonym: "abnormal basis stapedis morphology" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology

[Term]
id: MP:0004292
name: abnormal spiral ligament fibrocyte morphology
def: "any structural anomaly in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004288 ! abnormal spiral ligament morphology

[Term]
id: MP:0004293
name: abnormal type I spiral ligament fibrocytes
def: "any structural anomaly of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004292 ! abnormal spiral ligament fibrocyte morphology

[Term]
id: MP:0004294
name: abnormal type II spiral ligament fibrocytes
def: "any structural anomaly of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004292 ! abnormal spiral ligament fibrocyte morphology

[Term]
id: MP:0004295
name: abnormal type III spiral ligament fibrocytes
def: "any structural anomaly of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004292 ! abnormal spiral ligament fibrocyte morphology

[Term]
id: MP:0004296
name: abnormal type IV spiral ligament fibrocytes
def: "any structural anomaly of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004292 ! abnormal spiral ligament fibrocyte morphology

[Term]
id: MP:0004297
name: abnormal proprioceptive neuron morphology
def: "any structural anomaly of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene]
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology
is_a: MP:0000965 ! abnormal sensory neuron morphology

[Term]
id: MP:0004298
name: vestibular ganglion degeneration
def: "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [https://orcid.org/0000-0002-6490-7723]
synonym: "degeneration of ganglion vestibulare" EXACT []
synonym: "degeneration of Scarpa ganglion" EXACT []
is_a: MP:0002856 ! abnormal vestibular ganglion morphology

[Term]
id: MP:0004299
name: absent vestibular ganglion
def: "absence of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ganglion vestibulare" EXACT []
synonym: "absent Scarpa ganglion" EXACT []
is_a: MP:0002856 ! abnormal vestibular ganglion morphology

[Term]
id: MP:0004300
name: abnormal organ of Corti supporting cell morphology
def: "any structural anomaly in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal supporting cells of the organ of Corti" EXACT []
is_a: MP:0000042 ! abnormal organ of Corti morphology

[Term]
id: MP:0004301
name: absent organ of Corti supporting cells
def: "absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent supporting cells of the organ of Corti" EXACT []
is_a: MP:0004497 ! decreased organ of Corti supporting cell number

[Term]
id: MP:0004302
name: abnormal Deiters cell morphology
def: "any structural anomaly in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal phalangeal cell morphology" EXACT []
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology

[Term]
id: MP:0004303
name: abnormal Hensen cell morphology
def: "any structural anomaly in the supporting cells that form the lateral border of the organ of Corti, immediately to the outer side of Deiters' cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology

[Term]
id: MP:0004304
name: absent spiral limbus
def: "absence of the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent abnormal limbus spiralis" EXACT []
synonym: "absent limbus laminae spiralis osseae" EXACT []
is_a: MP:0004287 ! abnormal spiral limbus morphology

[Term]
id: MP:0004305
name: abnormal Rosenthal canal morphology
def: "any structural anomaly in the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea; it is divided incompletely into two compartments by a winding shelf of bone, the bony spiral lamina" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal canalis spiralis cochleae" EXACT []
synonym: "abnormal cochlear canal" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology
is_a: MP:0002729 ! abnormal inner ear canal morphology

[Term]
id: MP:0004306
name: small Rosenthal canal
def: "reduced size of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "small canalis spiralis cochleae" EXACT []
synonym: "small cochlear canal" EXACT []
is_a: MP:0004305 ! abnormal Rosenthal canal morphology

[Term]
id: MP:0004307
name: absent Rosenthal canal
def: "absence of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent canalis spiralis cochleae" EXACT []
synonym: "absent cochlear canal" RELATED []
is_a: MP:0004305 ! abnormal Rosenthal canal morphology

[Term]
id: MP:0004308
name: abnormal basilar membrane morphology
def: "any structural anomaly in the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal basilar lamina morphology" EXACT []
synonym: "abnormal basilar membrane of cochlear duct morphology" EXACT []
synonym: "abnormal lamina basilaris cochleae morphology" EXACT []
synonym: "abnormal lamina basilaris ductus cochlearis morphology" EXACT []
synonym: "abnormal membrana basilaris morphology" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0004309
name: absent otic vesicle
def: "absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent acoustic vesicle" EXACT []
synonym: "absent auditory vesicle" EXACT []
synonym: "absent otocyst" EXACT []
is_a: MP:0009806 ! abnormal otic vesicle morphology

[Term]
id: MP:0004310
name: small otic vesicle
def: "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "small acoustic vesicle" EXACT []
synonym: "small auditory vesicle" EXACT []
synonym: "small otocyst" EXACT []
is_a: MP:0009806 ! abnormal otic vesicle morphology

[Term]
id: MP:0004311
name: otic vesicle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the otic vesicle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "acoustic vesicle hypoplasia" EXACT []
synonym: "auditory vesicle hypoplasia" EXACT []
synonym: "hypoplastic otic vesicle" EXACT []
synonym: "hypoplastic otocyst" EXACT []
synonym: "otocyst hypoplasia" EXACT []
is_a: MP:0004310 ! small otic vesicle

[Term]
id: MP:0004312
name: absent pillar cells
def: "absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003825 ! abnormal pillar cell morphology

[Term]
id: MP:0004313
name: absent vestibulocochlear ganglion
def: "absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003703 ! abnormal vestibulocochlear ganglion morphology

[Term]
id: MP:0004314
name: absent inner ear vestibule
def: "absence of the cavity between the semicircular canals and the cochlea of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent vestibule" BROAD []
is_a: MP:0000034 ! abnormal inner ear vestibule morphology

[Term]
id: MP:0004315
name: absent vestibular saccule
def: "absence of the smaller of the two sacs in the vestibule" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent saccule" EXACT []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0004316
name: enlarged vestibular saccule
def: "enlarged size of the cavity between the semicircular canals and the cochlea of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged saccule" EXACT []
synonym: "increased vestibular saccule size" EXACT []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0004317
name: small vestibular saccule
def: "reduced size of the cavity between the semicircular canals and the cochlea of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased vestibular saccule size" EXACT []
synonym: "reduced vestibular saccule size" EXACT []
synonym: "small saccule" EXACT []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0004318
name: absent incus
def: "absence of the middle of the three auditory ossicles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000040 ! absent middle ear ossicles
is_a: MP:0005106 ! abnormal incus morphology

[Term]
id: MP:0004319
name: absent malleus
def: "absence of the largest of the three auditory ossicles, which resembles a club or hammer" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000029 ! abnormal malleus morphology
is_a: MP:0000040 ! absent middle ear ossicles

[Term]
id: MP:0004320
name: split sternum
def: "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [https://orcid.org/0000-0003-3691-0324]
synonym: "bifid sternum" EXACT []
synonym: "bifurcated sternum" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0004321
name: short sternum
def: "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased sternum length" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0004322
name: abnormal sternebra morphology
def: "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal sternebrae morphology" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0004323
name: sternum hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the sternum, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic sternum" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0004324
name: vestibular hair cell degeneration
def: "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002623 ! abnormal vestibular hair cell morphology
is_a: MP:0003224 ! neuron degeneration

[Term]
id: MP:0004325
name: absent vestibular hair cells
def: "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004328 ! decreased vestibular hair cell number

[Term]
id: MP:0004326
name: abnormal vestibular hair cell number
def: "abnormal number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002623 ! abnormal vestibular hair cell morphology

[Term]
id: MP:0004327
name: increased vestibular hair cell number
def: "increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004326 ! abnormal vestibular hair cell number
is_a: MP:0006006 ! increased sensory neuron number

[Term]
id: MP:0004328
name: decreased vestibular hair cell number
def: "decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced vestibular hair cell number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0004326 ! abnormal vestibular hair cell number

[Term]
id: MP:0004329
name: vestibular saccular degeneration
def: "degeneration or loss of the smaller of the two sacs in the vestibule" [https://orcid.org/0000-0002-6490-7723]
synonym: "saccular degeneration" RELATED []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0004330
name: abnormal vestibular saccular macula morphology
def: "any structural anomaly of the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal macula sacculi" EXACT []
synonym: "abnormal saccular macula morphology" EXACT []
synonym: "abnormal saccular spot" RELATED []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0004331
name: vestibular saccular macula degeneration
def: "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [https://orcid.org/0000-0002-6490-7723]
synonym: "saccular macula degeneration" EXACT []
is_a: MP:0004330 ! abnormal vestibular saccular macula morphology

[Term]
id: MP:0004332
name: utricular degeneration
def: "degeneration or loss of the larger of the two sacs in the vestibule" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0004333
name: abnormal utricular macula morphology
def: "any structural anomaly of the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal macula utriculi morphology" EXACT []
synonym: "abnormal utricular spot morphology" EXACT []
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0004334
name: utricular macular degeneration
def: "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004333 ! abnormal utricular macula morphology

[Term]
id: MP:0004335
name: enlarged utricle
def: "increased size of the larger of the two sacs in the vestibule" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased utricle size" EXACT []
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0004336
name: small utricle
def: "reduced size of the larger of the two sacs in the vestibule" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased utricle size" EXACT []
synonym: "reduced utricle size" EXACT []
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0004337
name: clavicle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the clavicle, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic clavicles" EXACT []
is_a: MP:0004338 ! small clavicle

[Term]
id: MP:0004338
name: small clavicle
def: "reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8]
is_a: MP:0005298 ! abnormal clavicle morphology

[Term]
id: MP:0004339
name: absent clavicle
def: "missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8]
is_a: MP:0005298 ! abnormal clavicle morphology

[Term]
id: MP:0004340
name: short scapula
def: "reduced length of either or both of the large, flat bones of the back part of the shoulder" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004343 ! small scapula

[Term]
id: MP:0004341
name: absent scapula
def: "missing either or both of the large, flat bones of the back part of the shoulder" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000149 ! abnormal scapula morphology

[Term]
id: MP:0004342
name: scapular bone foramen
def: "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [https://orcid.org/0000-0003-3691-0324]
synonym: "hole in scapula" EXACT []
synonym: "scapula foramen" EXACT []
synonym: "scapula hole" EXACT []
synonym: "scapular hole" EXACT []
is_a: MP:0000149 ! abnormal scapula morphology

[Term]
id: MP:0004343
name: small scapula
def: "reduced size of either or both of the large, flat bones of the back part of the shoulder" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000149 ! abnormal scapula morphology

[Term]
id: MP:0004344
name: scapular bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the scapular bone, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic scapular bone" EXACT []
is_a: MP:0004343 ! small scapula

[Term]
id: MP:0004345
name: abnormal acromion morphology
def: "any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder" [ISBN:0-683-40008-8]
synonym: "abnormal acromial process morphology" EXACT []
is_a: MP:0000149 ! abnormal scapula morphology

[Term]
id: MP:0004346
name: absent acromion
def: "lack of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder" [ISBN:0-683-40008-8]
synonym: "absence of acromion" EXACT []
synonym: "absent acromial process" EXACT []
is_a: MP:0004345 ! abnormal acromion morphology

[Term]
id: MP:0004347
name: abnormal scapular spine morphology
def: "any structural anomaly of the triangular ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached" [ISBN:0-683-40008-8]
synonym: "abnormal spine of scapula" EXACT []
is_a: MP:0000149 ! abnormal scapula morphology

[Term]
id: MP:0004348
name: long femur
def: "increased length of the long bone of the thigh" [ISBN:0-683-40008-8]
synonym: "increased femur length" EXACT []
is_a: MP:0004695 ! increased length of long bones
is_a: MP:0030823 ! increased femur size

[Term]
id: MP:0004349
name: absent femur
def: "missing the long bone of the thigh" [ISBN:0-683-40008-8]
is_a: MP:0000559 ! abnormal femur morphology

[Term]
id: MP:0004350
name: long humerus
def: "increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8]
synonym: "increased humerus length" EXACT []
is_a: MP:0004695 ! increased length of long bones
is_a: MP:0005296 ! abnormal humerus morphology

[Term]
id: MP:0004351
name: short humerus
def: "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8]
synonym: "decreased humerus length" EXACT []
is_a: MP:0004686 ! decreased length of long bones
is_a: MP:0005296 ! abnormal humerus morphology

[Term]
id: MP:0004352
name: absent humerus
def: "missing one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8]
is_a: MP:0005296 ! abnormal humerus morphology

[Term]
id: MP:0004353
name: abnormal deltoid tuberosity morphology
def: "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal deltoid crest" EXACT []
synonym: "abnormal deltoid eminence" EXACT []
synonym: "abnormal deltoid impression" EXACT []
synonym: "abnormal deltoid process" EXACT []
synonym: "abnormal deltopectoral crest morphology" EXACT [UBERON:0002498]
is_a: MP:0005296 ! abnormal humerus morphology

[Term]
id: MP:0004354
name: absent deltoid tuberosity
def: "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8]
synonym: "absent deltoid crest" EXACT []
synonym: "absent deltoid eminence" EXACT []
synonym: "absent deltoid impression" EXACT []
synonym: "absent deltoid process" EXACT []
is_a: MP:0004353 ! abnormal deltoid tuberosity morphology

[Term]
id: MP:0004355
name: short radius
def: "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8]
synonym: "decreased redius length" EXACT []
is_a: MP:0004686 ! decreased length of long bones
is_a: MP:0030886 ! decreased radius size

[Term]
id: MP:0004356
name: radius hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the radius, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic radius" EXACT []
is_a: MP:0030886 ! decreased radius size

[Term]
id: MP:0004357
name: long tibia
def: "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased tibia length" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0004695 ! increased length of long bones

[Term]
id: MP:0004358
name: bowed tibia
def: "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "bent tibia" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology

[Term]
id: MP:0004359
name: short ulna
def: "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8]
synonym: "decreased ulna length" EXACT []
is_a: MP:0004686 ! decreased length of long bones
is_a: MP:0030900 ! decreased ulna size

[Term]
id: MP:0004360
name: absent ulna
def: "missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8]
is_a: MP:0005108 ! abnormal ulna morphology

[Term]
id: MP:0004361
name: bowed ulna
def: "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8]
synonym: "bent ulna" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology

[Term]
id: MP:0004362
name: cochlear hair cell degeneration
def: "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "auditory hair cell degeneration" RELATED []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology
is_a: MP:0003224 ! neuron degeneration

[Term]
id: MP:0004363
name: stria vascularis degeneration
def: "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000032 ! cochlear degeneration
is_a: MP:0000048 ! abnormal stria vascularis morphology

[Term]
id: MP:0004364
name: thin stria vascularis
def: "reduced thickness of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000048 ! abnormal stria vascularis morphology

[Term]
id: MP:0004365
name: abnormal strial basal cell morphology
def: "any structural anomaly in the polarized cells which are juxtaposed to fibrocytes in the underlying spiral ligament" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal strial basal cells" BROAD []
is_a: MP:0000048 ! abnormal stria vascularis morphology

[Term]
id: MP:0004366
name: abnormal strial marginal cell morphology
def: "any structural anomaly in the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal strial marginal cells" RELATED []
is_a: MP:0000048 ! abnormal stria vascularis morphology

[Term]
id: MP:0004367
name: abnormal strial intermediate cell morphology
def: "any structural anomaly in the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cochlear melanocytes" BROAD []
synonym: "abnormal otic melanocytes" BROAD [ISBN:978-1-4051-2034-0]
synonym: "abnormal stria vascularis intermediate cells" BROAD []
synonym: "abnormal stria vascularis melanocytes" RELATED []
synonym: "abnormal strial intermediate cells" BROAD []
synonym: "abnormal strial melanocytes" BROAD []
is_a: MP:0000048 ! abnormal stria vascularis morphology
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0009390 ! abnormal otic pigmentation

[Term]
id: MP:0004368
name: abnormal stria vascularis vasculature morphology
def: "any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal stria vascularis blood vessels" EXACT []
synonym: "abnormal strial vascularization" EXACT []
is_a: MP:0000048 ! abnormal stria vascularis morphology
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0004369
name: absent utricle
def: "absence of the larger of the two sacs in the vestibule" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0004370
name: long ulna
def: "increased length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8]
synonym: "increased ulna length" EXACT []
is_a: MP:0004695 ! increased length of long bones
is_a: MP:0030901 ! increased ulna size

[Term]
id: MP:0004371
name: bowed femur
def: "increased curvature of the long bone of the thigh" [ISBN:0-683-40008-8]
synonym: "bent femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology

[Term]
id: MP:0004372
name: bowed fibula
def: "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8]
synonym: "bent fibula" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology

[Term]
id: MP:0004373
name: bowed humerus
def: "increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8]
synonym: "bent humerus" EXACT []
is_a: MP:0005296 ! abnormal humerus morphology

[Term]
id: MP:0004374
name: bowed radius
def: "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8]
synonym: "bent radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology

[Term]
id: MP:0004375
name: enlarged frontal bone
def: "increased size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
synonym: "increased frontal bone size" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology

[Term]
id: MP:0004376
name: absent frontal bone
def: "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
is_a: MP:0000107 ! abnormal frontal bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004377
name: small frontal bone
def: "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
synonym: "decreased frontal bone size" EXACT []
synonym: "reduced frontal bone size" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology

[Term]
id: MP:0004378
name: frontal bone foramen
def: "presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
synonym: "frontal bone hole" EXACT []
synonym: "hole in frontal bone" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology

[Term]
id: MP:0004379
name: wide frontal bone
def: "increased width of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
synonym: "increased frontal bone width" EXACT []
is_a: MP:0004375 ! enlarged frontal bone

[Term]
id: MP:0004380
name: short frontal bone
def: "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8]
synonym: "decreased frontal bone length" EXACT []
synonym: "reduced frontal bone length" EXACT []
is_a: MP:0004377 ! small frontal bone
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0004381
name: abnormal hair follicle melanocyte morphology
def: "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2]
synonym: "abnormal hair follicle melanocytes" EXACT []
is_a: MP:0002075 ! abnormal coat/hair pigmentation
is_a: MP:0002877 ! abnormal melanocyte morphology

[Term]
id: MP:0004382
name: abnormal hair follicle melanogenesis
def: "failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
is_a: MP:0005077 ! abnormal melanogenesis

[Term]
id: MP:0004383
name: absent interparietal bone
def: "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000077 ! abnormal interparietal bone morphology

[Term]
id: MP:0004384
name: small interparietal bone
def: "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased interparietal bone size" EXACT []
synonym: "reduced interparietal bone size" EXACT []
is_a: MP:0000077 ! abnormal interparietal bone morphology

[Term]
id: MP:0004385
name: interparietal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the interparietal bone, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic interparietal bone" EXACT []
is_a: MP:0004384 ! small interparietal bone

[Term]
id: MP:0004386
name: enlarged interparietal bone
def: "increased size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased interparietal bone size" EXACT []
is_a: MP:0000077 ! abnormal interparietal bone morphology

[Term]
id: MP:0004387
name: abnormal prechordal plate morphology
def: "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343]
synonym: "abnormal prochordal plate morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0004388
name: absent prechordal plate
def: "absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343]
is_a: MP:0004387 ! abnormal prechordal plate morphology

[Term]
id: MP:0004389
name: abnormal respiratory bronchiole morphology
def: "any structural anomaly of the smallest bronchioles, which connect the terminal bronchioles to alveolar ducts and have alveoli rising from their walls" [ISBN:0-683-40008-8, MGI:brs]
is_a: MP:0010911 ! abnormal pulmonary acinus morphology

[Term]
id: MP:0004390
name: abnormal bronchoalveolar duct junction morphology
def: "any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts" [ISBN:0-683-40008-8, MGI:brs]
is_a: MP:0002271 ! abnormal pulmonary alveolar duct morphology
is_a: MP:0004389 ! abnormal respiratory bronchiole morphology

[Term]
id: MP:0004391
name: abnormal respiratory conducting tube morphology
def: "any structural anomaly of the tubes of the respiratory system that allow passage of air from the trachea to the terminal bronchioles" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal conducting airways" EXACT []
synonym: "abnormal respiratory conducting zone" EXACT []
synonym: "abnormal respiratory passage" EXACT []
synonym: "airway malformation" BROAD []
xref: Fyler:4232
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0004392
name: abnormal CD8-positive, alpha-beta T cell physiology
def: "any functional anomaly of the subset of T lymphocytes that express the CD8 marker on the cell surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CD8+ T cell physiology" EXACT []
synonym: "abnormal CD8-positive T cell physiology" EXACT []
synonym: "abnormal single positive T cell physiology" BROAD []
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0004393
name: abnormal cochlear inner hair cell morphology
def: "any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell's surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory inner hair cell morphology" RELATED []
synonym: "abnormal cochlear IHCs" EXACT []
synonym: "abnormal cochlear inner hair cells" EXACT []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology

[Term]
id: MP:0004394
name: abnormal cochlear inner hair cell number
def: "abnormal number of the flask-shaped inner hair sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory inner hair cell number" EXACT []
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology

[Term]
id: MP:0004395
name: increased cochlear inner hair cell number
def: "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "extra IHCs" EXACT []
synonym: "extra row(s) of IHCs" EXACT []
synonym: "increased auditory IHCs" EXACT []
synonym: "increased auditory inner hair cell number" EXACT []
synonym: "supernumerary IHCs" EXACT []
is_a: MP:0004394 ! abnormal cochlear inner hair cell number
is_a: MP:0004407 ! increased cochlear hair cell number

[Term]
id: MP:0004396
name: decreased cochlear inner hair cell number
def: "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased auditory IHCs" EXACT []
synonym: "decreased auditory inner hair cell number" EXACT []
synonym: "decreased cochlear IHCs" RELATED []
synonym: "reduced cochlear inner hair cell number" EXACT []
is_a: MP:0004394 ! abnormal cochlear inner hair cell number
is_a: MP:0004408 ! decreased cochlear hair cell number

[Term]
id: MP:0004397
name: absent cochlear inner hair cells
def: "absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory IHCs" EXACT []
synonym: "absent cochlear IHCs" EXACT []
synonym: "absent IHCs" BROAD []
is_a: MP:0004396 ! decreased cochlear inner hair cell number

[Term]
id: MP:0004398
name: cochlear inner hair cell degeneration
def: "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "auditory inner hair cell degeneration" EXACT []
is_a: MP:0004362 ! cochlear hair cell degeneration
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology

[Term]
id: MP:0004399
name: abnormal cochlear outer hair cell morphology
def: "any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell's surface through the cuticular plate into the tectorial membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory outer hair cell morphology" EXACT []
synonym: "abnormal cochlear OHCs" EXACT []
synonym: "abnormal cochlear outer hair cells" EXACT []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology

[Term]
id: MP:0004400
name: abnormal cochlear outer hair cell number
def: "abnormal number of the columnar outer hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory outer hair cell number" EXACT []
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology

[Term]
id: MP:0004401
name: increased cochlear outer hair cell number
def: "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "extra OHCs" EXACT []
synonym: "extra row(s) of OHCs" EXACT []
synonym: "increased auditory OHCs" EXACT []
synonym: "increased auditory outer hair cell number" EXACT []
synonym: "supernumerary OHCs" EXACT []
is_a: MP:0004400 ! abnormal cochlear outer hair cell number
is_a: MP:0004407 ! increased cochlear hair cell number

[Term]
id: MP:0004402
name: decreased cochlear outer hair cell number
def: "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased auditory OHCs" EXACT []
synonym: "decreased auditory outer hair cell number" EXACT []
synonym: "decreased cochlear OHCs" RELATED []
synonym: "reduced cochlear outer hair cell number" EXACT []
is_a: MP:0004400 ! abnormal cochlear outer hair cell number
is_a: MP:0004408 ! decreased cochlear hair cell number

[Term]
id: MP:0004403
name: absent cochlear outer hair cells
def: "absence of the columnar outer hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory OHCs" EXACT []
synonym: "absent cochlear OHCs" EXACT []
is_a: MP:0004402 ! decreased cochlear outer hair cell number

[Term]
id: MP:0004404
name: cochlear outer hair cell degeneration
def: "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "auditory outer hair cell degeneration" EXACT []
is_a: MP:0004362 ! cochlear hair cell degeneration
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology

[Term]
id: MP:0004405
name: absent cochlear hair cells
def: "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory hair cells" RELATED []
is_a: MP:0004408 ! decreased cochlear hair cell number

[Term]
id: MP:0004406
name: abnormal cochlear hair cell number
def: "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory hair cell number" EXACT []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology

[Term]
id: MP:0004407
name: increased cochlear hair cell number
def: "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased auditory hair cell number" RELATED []
is_a: MP:0004406 ! abnormal cochlear hair cell number
is_a: MP:0006006 ! increased sensory neuron number

[Term]
id: MP:0004408
name: decreased cochlear hair cell number
def: "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased auditory hair cell number" RELATED []
synonym: "reduced cochlear hair cell number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0004406 ! abnormal cochlear hair cell number

[Term]
id: MP:0004409
name: abnormal crista ampullaris neuroepithelium morphology
def: "any structural anomaly in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ampullary crest neuroepithelium morphology" EXACT []
synonym: "abnormal neuroepithelium of ampullary crest" EXACT []
xref: MA:0002870
is_a: MP:0004249 ! abnormal crista ampullaris morphology

[Term]
id: MP:0004410
name: absent endocochlear potential
def: "absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent endolymphatic potential" EXACT []
synonym: "loss of endocochlear potential" EXACT []
is_a: MP:0002630 ! abnormal endocochlear potential

[Term]
id: MP:0004411
name: decreased endocochlear potential
def: "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased endolymphatic potential" EXACT []
synonym: "low endocochlear potential" EXACT []
synonym: "reduced endocochlear potential" EXACT []
synonym: "reduced endolymphatic potential" EXACT []
is_a: MP:0002630 ! abnormal endocochlear potential

[Term]
id: MP:0004412
name: abnormal cochlear microphonics
def: "any anomaly in the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004434 ! abnormal cochlear outer hair cell physiology
is_a: MP:0006332 ! abnormal cochlear potential

[Term]
id: MP:0004413
name: absent cochlear microphonics
def: "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cochlear potential" EXACT []
is_a: MP:0004412 ! abnormal cochlear microphonics

[Term]
id: MP:0004414
name: decreased cochlear microphonics
def: "reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cochlear potential" EXACT []
synonym: "reduced cochlear microphonics" EXACT []
synonym: "reduced cochlear potential" EXACT []
is_a: MP:0004412 ! abnormal cochlear microphonics

[Term]
id: MP:0004415
name: abnormal cochlear nerve compound action potential
def: "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory nerve compound action potential" RELATED []
is_a: MP:0005402 ! abnormal action potential
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0004416
name: absent cochlear nerve compound action potential
def: "absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory nerve compound action potential" RELATED []
is_a: MP:0004415 ! abnormal cochlear nerve compound action potential

[Term]
id: MP:0004417
name: decreased cochlear nerve compound action potential
def: "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased auditory nerve compound action potential" RELATED []
synonym: "reduced auditory nerve compound action potential" RELATED []
synonym: "reduced cochlear nerve compound action potential" EXACT []
is_a: MP:0004415 ! abnormal cochlear nerve compound action potential

[Term]
id: MP:0004418
name: small parietal bone
def: "reduced size of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased parietal bone size" EXACT []
synonym: "reduced parietal bone size" EXACT []
synonym: "small parietal bones" EXACT []
is_a: MP:0000109 ! abnormal parietal bone morphology

[Term]
id: MP:0004419
name: absent parietal bone
def: "absence of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent parietal bones" EXACT []
is_a: MP:0000109 ! abnormal parietal bone morphology

[Term]
id: MP:0004420
name: parietal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the parietal bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic parietal bone" EXACT []
synonym: "hypoplastic parietal bones" EXACT []
is_a: MP:0004418 ! small parietal bone

[Term]
id: MP:0004421
name: enlarged parietal bone
def: "increased size of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged parietal bones" EXACT []
synonym: "increased parietal bone size" EXACT []
is_a: MP:0000109 ! abnormal parietal bone morphology

[Term]
id: MP:0004422
name: small temporal bone
def: "reduced size of the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8]
synonym: "decreased temporal bone length" EXACT []
synonym: "reduced temporal bone length" EXACT []
is_a: MP:0005272 ! abnormal temporal bone morphology

[Term]
id: MP:0004423
name: abnormal temporal bone squamous part morphology
def: "any structural anomaly of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [http://www.medilexicon.com/dictionary/66008, https://en.wikipedia.org/wiki/Squamous_part_of_temporal_bone, https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/squamous-part-of-temporal-bone]
synonym: "abnormal os squamosum morphology" EXACT []
synonym: "abnormal pars squamosa (os temporale) morphology" EXACT []
synonym: "abnormal pars squamosa ossis temporalis morphology" EXACT []
synonym: "abnormal squama temporalis morphology" RELATED []
synonym: "abnormal squamosal bone morphology" EXACT []
synonym: "abnormal squamous bone morphology" EXACT []
synonym: "abnormal squamous temporal bone morphology" EXACT []
synonym: "abnormal temporal squama morphology" RELATED []
is_a: MP:0005272 ! abnormal temporal bone morphology

[Term]
id: MP:0004424
name: temporal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the temporal bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic temporal bone" EXACT []
is_a: MP:0004422 ! small temporal bone

[Term]
id: MP:0004425
name: abnormal otolith organ morphology
def: "any structural anomaly in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000034 ! abnormal inner ear vestibule morphology
is_a: MP:0004427 ! abnormal vestibular labyrinth morphology

[Term]
id: MP:0004426
name: abnormal cochlear labyrinth morphology
def: "any structural anomaly in the portion of the membranous labyrinth concerned with the sense of hearing (vs. the vestibular labyrinth, which is concerned with the sense of equilibration) and innervated by the cochlear nerve; it is located within the cochlea of the bony labyrinth, and consists of the cochlear duct, which contains the spiral organ" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal labyrinthus cochlearis" EXACT []
synonym: "abnormal organ of hearing" EXACT []
is_a: MP:0000035 ! abnormal membranous labyrinth morphology

[Term]
id: MP:0004427
name: abnormal vestibular labyrinth morphology
def: "any structural anomaly in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal labyrinthus vestibularis" BROAD []
synonym: "abnormal vestibular organ morphology" EXACT []
is_a: MP:0000035 ! abnormal membranous labyrinth morphology

[Term]
id: MP:0004428
name: abnormal type I vestibular cell
def: "any structural anomaly in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002623 ! abnormal vestibular hair cell morphology

[Term]
id: MP:0004429
name: abnormal type II vestibular cells
def: "any structural anomaly in the cylindrical sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear which are normally contacted by bouton endings of afferent and efferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002623 ! abnormal vestibular hair cell morphology

[Term]
id: MP:0004430
name: abnormal Claudius cell morphology
def: "any structural anomaly in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ (also known as the organ of Corti)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0004431
name: abnormal hair cell mechanoelectric transduction
def: "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003879 ! abnormal hair cell physiology

[Term]
id: MP:0004432
name: abnormal cochlear hair cell physiology
def: "any functional anomaly in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003879 ! abnormal hair cell physiology

[Term]
id: MP:0004433
name: abnormal cochlear inner hair cell physiology
def: "any functional anomaly in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cochlear IHC physiology" EXACT []
is_a: MP:0004432 ! abnormal cochlear hair cell physiology

[Term]
id: MP:0004434
name: abnormal cochlear outer hair cell physiology
def: "any functional anomaly in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cochlear OHC physiology" EXACT []
is_a: MP:0004432 ! abnormal cochlear hair cell physiology

[Term]
id: MP:0004435
name: abnormal cochlear outer hair cell electromotility
def: "anomalous motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal electromechanical transduction" EXACT []
synonym: "abnormal OHC electromotility" EXACT []
is_a: MP:0004434 ! abnormal cochlear outer hair cell physiology

[Term]
id: MP:0004436
name: absent cochlear outer hair cell electromotility
def: "absence or loss of motility of the cochlear OHCs in response to electrical stimulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent OHC electromotility" EXACT []
is_a: MP:0004435 ! abnormal cochlear outer hair cell electromotility

[Term]
id: MP:0004437
name: decreased cochlear outer hair cell electromotility
def: "reduced motility of the cochlear OHCs in response to electrical stimulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cochlear outer hair cell electromotility" EXACT []
synonym: "reduced OHC electromotility" EXACT []
is_a: MP:0004435 ! abnormal cochlear outer hair cell electromotility

[Term]
id: MP:0004438
name: abnormal vestibular hair cell physiology
def: "anomalies in processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003879 ! abnormal hair cell physiology

[Term]
id: MP:0004439
name: absent Meckel's cartilage
def: "absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8]
is_a: MP:0005587 ! abnormal Meckel's cartilage morphology

[Term]
id: MP:0004440
name: absent occipital bone
def: "absence of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8]
is_a: MP:0005269 ! abnormal occipital bone morphology

[Term]
id: MP:0004441
name: small occipital bone
def: "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8]
synonym: "decreased occipital bone size" EXACT []
synonym: "reduced occipital bone size" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology

[Term]
id: MP:0004442
name: occipital bone foramen
def: "presence of a hole in the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8]
synonym: "hole in occipital bone" EXACT []
synonym: "occipital bone hole" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology

[Term]
id: MP:0004443
name: absent supraoccipital bone
def: "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000078 ! abnormal supraoccipital bone morphology

[Term]
id: MP:0004444
name: small supraoccipital bone
def: "reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased supraoccipital bone size" EXACT []
synonym: "reduced supraoccipital bone size" EXACT []
is_a: MP:0000078 ! abnormal supraoccipital bone morphology

[Term]
id: MP:0004445
name: small exoccipital bone
def: "reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8]
synonym: "decreased exoccipital bone size" EXACT []
synonym: "reduced exoccipital bone size" EXACT []
is_a: MP:0000080 ! abnormal exoccipital bone morphology

[Term]
id: MP:0004446
name: split exoccipital bone
def: "the appearance of an abnormal division in the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8]
synonym: "bifid exoccipital bone" EXACT []
is_a: MP:0000080 ! abnormal exoccipital bone morphology

[Term]
id: MP:0004447
name: small basioccipital bone
def: "reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8]
synonym: "decreased basioccipital bone size" EXACT []
synonym: "reduced basioccipital bone size" EXACT []
is_a: MP:0000079 ! abnormal basioccipital bone morphology

[Term]
id: MP:0004448
name: abnormal presphenoid bone morphology
def: "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8]
is_a: MP:0000104 ! abnormal sphenoid bone morphology

[Term]
id: MP:0004449
name: absent presphenoid bone
def: "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8]
is_a: MP:0004448 ! abnormal presphenoid bone morphology

[Term]
id: MP:0004450
name: presphenoid bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the presphenoid bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic presphenoid bone" EXACT []
is_a: MP:0030383 ! small presphenoid bone
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004451
name: short presphenoid bone
def: "reduced length of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8]
synonym: "decreased presphenoid bone length" EXACT []
synonym: "reduced presphenoid bone length" EXACT []
is_a: MP:0030383 ! small presphenoid bone

[Term]
id: MP:0004452
name: abnormal pterygoid process morphology
def: "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8]
is_a: MP:0000104 ! abnormal sphenoid bone morphology

[Term]
id: MP:0004453
name: abnormal pterygoid bone morphology
def: "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8]
is_a: MP:0004452 ! abnormal pterygoid process morphology

[Term]
id: MP:0004454
name: absent pterygoid process
def: "absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8]
is_a: MP:0004452 ! abnormal pterygoid process morphology

[Term]
id: MP:0004455
name: pterygoid bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pterygoid bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic pterygoid bone" EXACT []
is_a: MP:0004456 ! small pterygoid bone

[Term]
id: MP:0004456
name: small pterygoid bone
def: "reduced size of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8]
synonym: "decreased pterygoid bone size" EXACT []
synonym: "reduced pterygoid bone size" EXACT []
is_a: MP:0004453 ! abnormal pterygoid bone morphology

[Term]
id: MP:0004457
name: abnormal orbitosphenoid bone morphology
def: "any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [ISBN:0-683-40008-8]
synonym: "abnormal alae orbitales morphology" RELATED []
synonym: "abnormal lesser wing of the sphenoid bone" EXACT []
synonym: "abnormal small wing of the sphenoid bone" EXACT []
is_a: MP:0000104 ! abnormal sphenoid bone morphology
is_a: MP:0010030 ! abnormal orbit morphology

[Term]
id: MP:0004458
name: absent alisphenoid bone
def: "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8]
is_a: MP:0003235 ! abnormal alisphenoid bone morphology

[Term]
id: MP:0004459
name: small alisphenoid bone
def: "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8]
synonym: "decreased alisphenoid bone sze" EXACT []
synonym: "reduced alisphenoid bone sze" EXACT []
is_a: MP:0003235 ! abnormal alisphenoid bone morphology

[Term]
id: MP:0004460
name: alisphenoid bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the alisphenoid bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "decreased alisphenoid bone cellularity" RELATED []
synonym: "hypoplastic alisphenoid bone" EXACT []
is_a: MP:0004459 ! small alisphenoid bone
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004461
name: basisphenoid bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the basisphenoid bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "decreased basisphenoid bone cellularity" RELATED []
synonym: "hypoplastic basisphenoid bone" EXACT []
is_a: MP:0004462 ! small basisphenoid bone
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004462
name: small basisphenoid bone
def: "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8]
synonym: "decreased basisphenoid bone sze" EXACT []
synonym: "reduced basisphenoid bone sze" EXACT []
is_a: MP:0000106 ! abnormal basisphenoid bone morphology

[Term]
id: MP:0004463
name: basisphenoid bone foramen
def: "the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8]
synonym: "basisphenoid bone hole" EXACT []
synonym: "hole in basisphenoid bone" EXACT []
is_a: MP:0000106 ! abnormal basisphenoid bone morphology

[Term]
id: MP:0004464
name: absent strial basal cell tight junctions
def: "absence of tight junctions from the basal cell layer of stria vascularis, resulting in destruction of the paracellular barrier between basal cells; loss of basal cell tight junctions renders the intrastrial space open to perilymph and abolishes its electrical isolation" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004365 ! abnormal strial basal cell morphology

[Term]
id: MP:0004465
name: degeneration of organ of Corti supporting cells
def: "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "degeneration of the supporting cells of the organ of Corti" EXACT []
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology

[Term]
id: MP:0004466
name: short cochlear outer hair cells
def: "reduced height of the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve" [https://orcid.org/0000-0003-3691-0324]
synonym: "short auditory outer hair cells" EXACT []
synonym: "short cochlear OHCs" EXACT []
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology

[Term]
id: MP:0004467
name: absent zygomatic bone
def: "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8]
is_a: MP:0005270 ! abnormal zygomatic bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004468
name: small zygomatic bone
def: "reduced size of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8]
is_a: MP:0005270 ! abnormal zygomatic bone morphology

[Term]
id: MP:0004469
name: abnormal zygomatic arch morphology
def: "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8]
synonym: "abnormal malar arch morphology" EXACT []
synonym: "abnormal zygoma morphology" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0004470
name: small nasal bone
def: "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8]
synonym: "decreased nasal bone size" EXACT []
synonym: "reduced nasal bone size" EXACT []
is_a: MP:0000102 ! abnormal nasal bone morphology

[Term]
id: MP:0004471
name: short nasal bone
def: "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8]
synonym: "decreased nasal bone length" EXACT []
is_a: MP:0004470 ! small nasal bone
is_a: MP:0030384 ! short facial bone

[Term]
id: MP:0004472
name: broad nasal bone
def: "increased width of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8]
synonym: "wide nasal bone" EXACT []
is_a: MP:0004474 ! enlarged nasal bone

[Term]
id: MP:0004473
name: absent nasal bone
def: "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8]
is_a: MP:0000102 ! abnormal nasal bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004474
name: enlarged nasal bone
def: "increased size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8]
synonym: "increased nasal bone size" EXACT []
is_a: MP:0000102 ! abnormal nasal bone morphology

[Term]
id: MP:0004475
name: palatine bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the palatine bone, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic palatine bone" EXACT []
is_a: MP:0005249 ! abnormal palatine bone morphology
is_a: MP:0009892 ! palate bone hypoplasia
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004476
name: absent palatine bone
def: "absence of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits" [ISBN:0-683-40008-8]
is_a: MP:0005249 ! abnormal palatine bone morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004477
name: turbinate hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the turbinate, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic turbinate" EXACT []
is_a: MP:0002244 ! abnormal turbinate morphology

[Term]
id: MP:0004478
name: increased testicular teratoma incidence
def: "greater than the expected number of a usually benign tumor found in the testis that is the result of an anomaly of germ cell development, occurring in a specific population in a given time period; teratomas typically contains a diversity of tissues often representing all organ systems such as hair, teeth, bone, thyroid, or nerve tissue" [MGI:llw2]
synonym: "testicular teratoma" RELATED []
is_a: MP:0002627 ! increased teratoma incidence
is_a: MP:0006262 ! increased testis tumor incidence

[Term]
id: MP:0004479
name: abnormal oval window morphology
def: "any structural anomaly of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes" [ISBN:0-683-40008-8]
synonym: "abnormal fenestra of the vestibule" EXACT []
synonym: "abnormal fenestra ovalis" EXACT []
synonym: "abnormal fenestra vestibuli" EXACT []
synonym: "abnormal vestibular window" EXACT []
is_a: MP:0000049 ! abnormal middle ear morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology

[Term]
id: MP:0004480
name: abnormal round window morphology
def: "any structural anomaly of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [ISBN:0-683-40008-8]
synonym: "abnormal cochlear window" EXACT []
synonym: "abnormal fenestra cochleae" EXACT []
synonym: "abnormal fenestra of the cochlea" EXACT []
synonym: "abnormal fenestra rotunda" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0000049 ! abnormal middle ear morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology

[Term]
id: MP:0004481
name: abnormal conjunctival epithelium morphology
def: "any structural anomaly of the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001310 ! abnormal conjunctiva morphology

[Term]
id: MP:0004482
name: abnormal interdental cell morphology
def: "any structural anomaly of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004287 ! abnormal spiral limbus morphology

[Term]
id: MP:0004483
name: absent interdental cells
def: "absence of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004482 ! abnormal interdental cell morphology

[Term]
id: MP:0004484
name: abnormal response of heart to induced stress
def: "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [https://orcid.org/0000-0003-3691-0324]
synonym: "altered response of heart to induced stress" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0004485
name: increased response of heart to induced stress
def: "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased protection of heart to induced stress" EXACT []
is_a: MP:0004484 ! abnormal response of heart to induced stress
is_a: MP:0005165 ! increased susceptibility to injury

[Term]
id: MP:0004486
name: decreased response of heart to induced stress
def: "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased protection of heart from induced stress" EXACT []
synonym: "reduced response of heart to induced stress" EXACT []
is_a: MP:0004484 ! abnormal response of heart to induced stress
is_a: MP:0005166 ! decreased susceptibility to injury

[Term]
id: MP:0004487
name: type I spiral ligament fibrocyte degeneration
def: "degeneration or loss of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004293 ! abnormal type I spiral ligament fibrocytes

[Term]
id: MP:0004488
name: type II spiral ligament fibrocyte degeneration
def: "degeneration or loss of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004294 ! abnormal type II spiral ligament fibrocytes

[Term]
id: MP:0004489
name: type III spiral ligament fibrocyte degeneration
def: "degeneration or loss of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004295 ! abnormal type III spiral ligament fibrocytes

[Term]
id: MP:0004490
name: type IV spiral ligament fibrocyte degeneration
def: "degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004296 ! abnormal type IV spiral ligament fibrocytes

[Term]
id: MP:0004491
name: abnormal orientation of outer hair cell stereociliary bundles
def: "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004522 ! abnormal orientation of cochlear hair cell stereociliary bundles
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology

[Term]
id: MP:0004492
name: abnormal orientation of inner hair cell stereociliary bundles
def: "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004522 ! abnormal orientation of cochlear hair cell stereociliary bundles
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology

[Term]
id: MP:0004493
name: dilated cochlea
def: "the luminal space of the cochlea is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "cochlea dilation" EXACT []
synonym: "cochlear dilation" EXACT []
synonym: "dilated cochleas" EXACT []
is_a: MP:0014297 ! abnormal cochlea size

[Term]
id: MP:0004494
name: abnormal synaptic glutamate release
def: "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs]
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0004495
name: decreased synaptic glutamate release
def: "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs]
synonym: "reduced synaptic glutamate release" EXACT []
is_a: MP:0003990 ! decreased neurotransmitter release
is_a: MP:0004494 ! abnormal synaptic glutamate release

[Term]
id: MP:0004496
name: abnormal organ of Corti supporting cell number
def: "abnormal number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal number of supporting cells of the organ of Corti" RELATED []
synonym: "abnormal supporting cell number of the organ of Corti" EXACT []
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology

[Term]
id: MP:0004497
name: decreased organ of Corti supporting cell number
def: "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased number of supporting cells of the organ of Corti" EXACT []
synonym: "decreased supporting cell number of the organ of Corti" EXACT []
synonym: "reduced supporting cell number of the organ of Corti" RELATED []
is_a: MP:0004496 ! abnormal organ of Corti supporting cell number

[Term]
id: MP:0004498
name: increased organ of Corti supporting cell number
def: "increased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased number of supporting cells of the organ of Corti" EXACT []
synonym: "increased supporting cell number of the organ of Corti" EXACT []
is_a: MP:0004496 ! abnormal organ of Corti supporting cell number

[Term]
id: MP:0004499
name: increased incidence of tumors by chemical induction
def: "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased incidence of chemically-induced tumors" EXACT []
synonym: "increased incidence of chemically-induced tumours" EXACT []
synonym: "increased incidence of tumours by chemical induction" EXACT []
is_a: MP:0002021 ! increased incidence of induced tumors
is_a: MP:0008873 ! increased physiological sensitivity to xenobiotic

[Term]
id: MP:0004500
name: increased incidence of tumors by ionizing radiation induction
def: "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased incidence of ionizing radiation-induced tumors" EXACT []
synonym: "increased incidence of ionizing radiation-induced tumours" EXACT []
synonym: "increased incidence of tumours by ionizing radiation induction" EXACT []
is_a: MP:0002021 ! increased incidence of induced tumors

[Term]
id: MP:0004501
name: increased incidence of tumors by UV-induction
def: "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased incidence of tumours by UV-induction" EXACT []
synonym: "increased incidence of UV-induced tumors" EXACT []
synonym: "increased incidence of UV-induced tumours" EXACT []
is_a: MP:0002021 ! increased incidence of induced tumors

[Term]
id: MP:0004502
name: decreased incidence of tumors by chemical induction
def: "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased incidence of chemically-induced tumors" EXACT []
synonym: "decreased incidence of chemically-induced tumours" EXACT []
synonym: "decreased incidence of tumours by chemical induction" EXACT []
synonym: "reduced incidence of chemically-induced tumors" EXACT []
synonym: "reduced incidence of chemically-induced tumours" EXACT []
is_a: MP:0002053 ! decreased incidence of induced tumors
is_a: MP:0008874 ! decreased physiological sensitivity to xenobiotic

[Term]
id: MP:0004503
name: decreased incidence of tumors by ionizing radiation induction
def: "lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased incidence of ionizing radiation-induced tumors" EXACT []
synonym: "decreased incidence of ionizing radiation-induced tumours" EXACT []
synonym: "decreased incidence of tumours by ionizing radiation induction" EXACT []
synonym: "reduced incidence of ionizing radiation-induced tumors" EXACT []
synonym: "reduced incidence of ionizing radiation-induced tumours" EXACT []
is_a: MP:0002053 ! decreased incidence of induced tumors

[Term]
id: MP:0004504
name: decreased incidence of tumors by UV induction
def: "lower than normal frequency of tumor incidence induced by exposure to ultraviolet light" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased incidence of tumours by UV induction" EXACT []
synonym: "decreased incidence of UV-induced tumors" EXACT []
synonym: "decreased incidence of UV-induced tumours" EXACT []
synonym: "reduced incidence of tumors by UV induction" EXACT []
synonym: "reduced incidence of tumours by UV induction" EXACT []
synonym: "reduced incidence of UV-induced tumors" EXACT []
synonym: "reduced incidence of UV-induced tumours" EXACT []
is_a: MP:0002053 ! decreased incidence of induced tumors

[Term]
id: MP:0004505
name: decreased renal glomerulus number
def: "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased number of renal glomeruli" EXACT []
synonym: "reduced glomerulus number" EXACT []
synonym: "reduced number of glomeruli" EXACT []
synonym: "reduced renal glomerulus number" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology

[Term]
id: MP:0004506
name: abnormal pubis morphology
def: "any structural anomaly of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal pubic bone morphology" EXACT []
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology

[Term]
id: MP:0004507
name: abnormal ischium morphology
def: "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology

[Term]
id: MP:0004508
name: abnormal pectoral girdle bone morphology
def: "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton" [MGI:cwg]
synonym: "abnormal shoulder bone morphology" EXACT []
synonym: "abnormal shoulder girdle morphology" EXACT []
synonym: "shoulder bone dysplasia" NARROW []
is_a: MP:0009250 ! abnormal appendicular skeleton morphology

[Term]
id: MP:0004509
name: abnormal pelvic girdle bone morphology
def: "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal coxal bones" BROAD []
synonym: "abnormal innominate bones" BROAD []
synonym: "abnormal pelvic bone morphology" EXACT []
synonym: "abnormal pelvis bones" BROAD []
synonym: "pelvic girdle bone dysplasia" NARROW []
is_a: MP:0009250 ! abnormal appendicular skeleton morphology

[Term]
id: MP:0004510
name: myositis
alt_id: MP:0001865
alt_id: MP:0004511
def: "inflammation of muscle; local accumulation of fluid, plasma proteins, and leukocytes in muscle" [ISBN:0-683-40008-8]
synonym: "muscle inflammation" EXACT []
synonym: "skeletal muscle inflammation" EXACT []
synonym: "striated muscle inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0004512
name: anosmia
def: "loss of the sense of smell" [MGI:mberry]
is_a: MP:0001984 ! abnormal olfaction

[Term]
id: MP:0004513
name: avnosmia
def: "loss of the ability to detect pheromones through the vomeronasal system" [https://orcid.org/0000-0003-3691-0324, PMID:12214233]
is_a: MP:0005423 ! abnormal somatic nervous system physiology

[Term]
id: MP:0004514
name: dystocia
def: "slow or difficult delivery of offspring and/or placenta" [MESH:C13.703.420.288]
is_a: MP:0002907 ! abnormal parturition

[Term]
id: MP:0004515
name: abnormal vestibular hair cell stereociliary bundle morphology
def: "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vestibular hair bundles" RELATED []
synonym: "abnormal vestibular hair cell stereocilia" EXACT []
synonym: "abnormal vestibular hair cell stereociliary bundles" EXACT []
is_a: MP:0002623 ! abnormal vestibular hair cell morphology

[Term]
id: MP:0004516
name: fused vestibular hair cell stereocilia
def: "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells, often resulting in giant stereocilia" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused vestibular stereocilia" EXACT []
synonym: "fusion of vestibular hair cell stereocilia" EXACT []
synonym: "giant vestibular stereocilia" EXACT []
synonym: "vestibular hair cell stereocilia fusion" EXACT []
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004517
name: decreased vestibular hair cell stereocilia number
def: "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced vestibular hair cell stereocilia number" EXACT []
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004518
name: absent vestibular hair cell stereocilia
def: "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004519
name: thin vestibular hair cell stereocilia
def: "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004520
name: short vestibular hair cell stereocilia
def: "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004521
name: abnormal cochlear hair cell stereociliary bundle morphology
def: "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cochlear hair bundles" EXACT []
synonym: "abnormal cochlear hair cell stereocilia" EXACT []
synonym: "abnormal cochlear hair cell stereociliary bundles" EXACT []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology

[Term]
id: MP:0004522
name: abnormal orientation of cochlear hair cell stereociliary bundles
def: "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004523
name: decreased cochlear hair cell stereocilia number
def: "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cochlear hair cell stereocilia number" EXACT []
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004524
name: short cochlear hair cell stereocilia
def: "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004525
name: thin cochlear hair cell stereocilia
def: "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004526
name: absent cochlear hair cell stereocilia
def: "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cochlear hair cell stereocilium" EXACT []
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004527
name: abnormal outer hair cell stereociliary bundle morphology
def: "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal OHC bundles" EXACT []
synonym: "abnormal OHC stereocilia" EXACT []
synonym: "abnormal OHC stereociliary bundles" EXACT []
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004528
name: fused outer hair cell stereocilia
def: "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused OHC stereocilia" EXACT []
synonym: "fusion of outer hair cell stereocilia" EXACT []
synonym: "giant OHC stereocilia" EXACT []
synonym: "outer hair cell stereocilia fusion" EXACT []
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology

[Term]
id: MP:0004529
name: decreased outer hair cell stereocilia number
def: "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced outer hair cell stereocilia number" EXACT []
is_a: MP:0004523 ! decreased cochlear hair cell stereocilia number
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology

[Term]
id: MP:0004530
name: absent outer hair cell stereocilia
def: "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology

[Term]
id: MP:0004531
name: short outer hair cell stereocilia
def: "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased OHC stereocilia length" EXACT []
synonym: "reduced OHC stereocilium length" EXACT []
is_a: MP:0004524 ! short cochlear hair cell stereocilia
is_a: MP:0014411 ! abnormal outer hair cell stereocilia length

[Term]
id: MP:0004532
name: abnormal inner hair cell stereociliary bundle morphology
def: "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal IHC bundles" EXACT []
synonym: "abnormal IHC stereocilia" EXACT []
synonym: "abnormal IHC stereociliary bundles" EXACT []
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004533
name: fused inner hair cell stereocilia
def: "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused IHC stereocilia" EXACT []
synonym: "fusion of inner hair cell stereocilia" EXACT []
synonym: "giant IHC stereocilia" EXACT []
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology

[Term]
id: MP:0004534
name: decreased inner hair cell stereocilia number
def: "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced inner hair cell stereocilia number" EXACT []
is_a: MP:0004523 ! decreased cochlear hair cell stereocilia number
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology

[Term]
id: MP:0004535
name: absent inner hair cell stereocilia
def: "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology

[Term]
id: MP:0004536
name: short inner hair cell stereocilia
def: "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004524 ! short cochlear hair cell stereocilia
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology

[Term]
id: MP:0004537
name: abnormal palatine bone horizontal plate morphology
def: "any structural anomaly of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal horizontal plate" EXACT []
synonym: "abnormal palatal process of palatine bone" EXACT []
synonym: "abnormal palatine palatal process" EXACT []
synonym: "abnormal palatine shelf morphology" EXACT []
is_a: MP:0005249 ! abnormal palatine bone morphology
is_a: MP:0009891 ! abnormal palate bone morphology

[Term]
id: MP:0004538
name: abnormal maxillary shelf morphology
def: "any structural anomaly of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal maxillary palatal process" EXACT []
synonym: "abnormal palatal process of maxilla" EXACT []
synonym: "abnormal palatine process" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
is_a: MP:0009891 ! abnormal palate bone morphology

[Term]
id: MP:0004539
name: absent maxilla
def: "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8]
synonym: "absence of upper jaw" EXACT []
synonym: "absent upper jaw" EXACT []
synonym: "agenesis of the maxilla" EXACT []
synonym: "agenesis of the upper jaw bone" EXACT []
synonym: "aplasia of the maxilla" EXACT []
synonym: "aplasia of the upper jaw bone" EXACT []
synonym: "maxillary agenesis" EXACT []
synonym: "maxillary agnathia" EXACT []
synonym: "maxillary aplasia" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
is_a: MP:0030268 ! agnathia
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004540
name: small maxilla
def: "reduced size of the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8]
synonym: "decreased maxilla size" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology

[Term]
id: MP:0004541
name: absent auditory tube
def: "absence of the tube connecting the tympanic cavity and the nasopharynx" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent Eustachian tube" EXACT []
synonym: "absent pharyngotympanic tube" EXACT []
is_a: MP:0003330 ! abnormal auditory tube morphology

[Term]
id: MP:0004542
name: impaired acrosome reaction
def: "reduced ability or inability to execute the cellular exocytosis of a single, anterior secretory granule following a sperm's attachment to the zona pellucida surrounding an oocyte" [GO:0007340, https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000242 ! impaired fertilization
is_a: MP:0013287 ! abnormal acrosome reaction

[Term]
id: MP:0004543
name: abnormal sperm physiology
def: "anomaly in the normal function of spermatozoa" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0004544
name: absent esophagus
def: "absence of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent oesophagus" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0004545
name: enlarged esophagus
def: "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged oesophagus" EXACT []
synonym: "increased esophagus size" EXACT []
synonym: "increased oesophagus size" EXACT []
synonym: "megaesophagus" RELATED []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0004546
name: esophagus hyperplasia
def: "increase in the number of normal cells in normal arrangement in the esophagus, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "esophageal hyperplasia" EXACT []
synonym: "hyperplastic esophagus" EXACT []
synonym: "hyperplastic oesophagus" EXACT []
synonym: "oesophageal hyperplasia" EXACT []
synonym: "oesophagus hyperplasia" EXACT []
is_a: MP:0004545 ! enlarged esophagus

[Term]
id: MP:0004547
name: esophageal ulcer
def: "a lesion on the mucosal surface of the esophagus, usually produced by the sloughing of inflammatory necrotic tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "oesophageal ulcer" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0004548
name: dilated esophagus
def: "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated esophagi" EXACT []
synonym: "dilated oesophagus" EXACT []
synonym: "esophageal dilation" EXACT []
synonym: "esophagus dilation" EXACT []
synonym: "oesophageal dilation" EXACT []
synonym: "oesophagus dilation" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0004549
name: small trachea
def: "reduced size of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0004550
name: short trachea
def: "reduced length of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004549 ! small trachea

[Term]
id: MP:0004551
name: decreased tracheal cartilage ring number
def: "less than the expected number of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing" [https://orcid.org/0000-0002-6490-7723]
comment: The rodent trachea contains C-shaped incomplete cartilaginous rings that vary in number between mice (15-18) and rats (20-25). A total of 15-20 incomplete U-shaped cartilaginous rings support the human trachea. {xref="ISBN:978-0-12-802900-8"}
synonym: "reduced tracheal cartilage ring number" EXACT []
synonym: "reduced tracheal ring number" EXACT []
is_a: MP:0003120 ! abnormal tracheal cartilage morphology

[Term]
id: MP:0004552
name: fused tracheal cartilage rings
def: "fusion of some or all of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused tracheal rings" EXACT []
synonym: "fusion of tracheal cartilage rings" EXACT []
synonym: "tracheal cartilage ring fusion" EXACT []
is_a: MP:0003120 ! abnormal tracheal cartilage morphology

[Term]
id: MP:0004553
name: absent tracheal cartilage rings
def: "absence of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent tracheal cartilage" EXACT []
synonym: "absent tracheal rings" EXACT []
is_a: MP:0004551 ! decreased tracheal cartilage ring number

[Term]
id: MP:0004554
name: small pharynx
def: "reduced size of the passage between the mouth and the posterior nares and the larynx and esophagus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0004555
name: pharynx hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pharynx, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic pharynx" EXACT []
synonym: "pharyngeal hypoplasia" EXACT []
is_a: MP:0004554 ! small pharynx

[Term]
id: MP:0004556
name: enlarged allantois
def: "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased allantois size" EXACT []
is_a: MP:0001726 ! abnormal allantois morphology

[Term]
id: MP:0004557
name: dilated allantois
def: "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [https://orcid.org/0000-0002-6490-7723]
synonym: "allantois dilation" EXACT []
synonym: "distended allantois" EXACT []
synonym: "swollen allantois" EXACT []
is_a: MP:0001726 ! abnormal allantois morphology

[Term]
id: MP:0004558
name: delayed allantois development
def: "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "retarded allantois formation" EXACT []
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology

[Term]
id: MP:0004559
name: small allantois
def: "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased allantois size" EXACT []
is_a: MP:0001726 ! abnormal allantois morphology

[Term]
id: MP:0004560
name: abnormal chorionic plate morphology
def: "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0009-0005-7755-8314]
is_a: MP:0001711 ! abnormal placenta morphology
is_a: MP:0002836 ! abnormal chorion morphology

[Term]
id: MP:0004561
name: absent facial nerve
def: "absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [ISBN:0838580343]
is_a: MP:0001071 ! abnormal facial nerve morphology

[Term]
id: MP:0004562
name: abnormal inner hair cell synaptic ribbon morphology
def: "any structural anomaly in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal IHC synaptic ribbon" EXACT []
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology

[Term]
id: MP:0004563
name: absent active-zone-anchored inner hair cell synaptic ribbon
def: "absence or loss of the usually single synaptic ribbon, a characteristic osmiophilic, electron-dense structure to which synaptic vesicles are tethered at the active zone of the cochlear inner hair cell afferent synapse" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent IHC synaptic ribbon" EXACT []
is_a: MP:0004562 ! abnormal inner hair cell synaptic ribbon morphology

[Term]
id: MP:0004564
name: increased myocardial fiber size
def: "increased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [https://orcid.org/0009-0005-7755-8314]
synonym: "enlarged adult cardiomyocyte" EXACT []
synonym: "enlarged myocardial fiber" EXACT []
synonym: "enlarged myocardial fibre" EXACT []
synonym: "increased adult cardiomyocyte size" EXACT []
synonym: "increased myocardial fibre size" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0004565
name: decreased myocardial fiber size
def: "decreased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased adult cardiomyocyte size" EXACT []
synonym: "decreased myocardial fibre size" EXACT []
synonym: "reduced myocardial fiber size" EXACT []
synonym: "reduced myocardial fibre size" EXACT []
synonym: "small adult cardiomyocyte" EXACT []
synonym: "small myocardial fiber" EXACT []
synonym: "small myocardial fibre" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0004566
name: myocardial fiber degeneration
def: "deterioration or destruction of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [https://orcid.org/0009-0005-7755-8314]
synonym: "adult cardiomyocyte degeneration" EXACT []
synonym: "myocardial fibre degeneration" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0004567
name: decreased myocardial fiber number
def: "decreased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased adult cardiomyocyte number" EXACT []
synonym: "decreased myocardial fibre number" EXACT []
synonym: "reduced adult cardiomyocyte number" EXACT []
synonym: "reduced myocardial fiber number" EXACT []
synonym: "reduced myocardial fibre number" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0004568
name: fusion of glossopharyngeal and vagus nerve
def: "union of the ninth and tenth cranial nerves into a single structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "fused glossopharyngeal and vagus nerves" RELATED []
synonym: "glossopharyngeal and vagus nerve fusion" EXACT []
is_a: MP:0001073 ! abnormal glossopharyngeal nerve morphology
is_a: MP:0001074 ! abnormal vagus nerve morphology

[Term]
id: MP:0004569
name: glossopharyngeal nerve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the glossopharyngeal nerve, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "hypoplastic glossopharyngeal nerve" EXACT []
is_a: MP:0001073 ! abnormal glossopharyngeal nerve morphology

[Term]
id: MP:0004570
name: absent glossopharyngeal nerve
def: "absence of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
is_a: MP:0001073 ! abnormal glossopharyngeal nerve morphology

[Term]
id: MP:0004571
name: absent vagus nerve
def: "absence of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "absent CN-X" EXACT []
synonym: "absent vagal nerve" EXACT []
is_a: MP:0001074 ! abnormal vagus nerve morphology

[Term]
id: MP:0004572
name: fusion of basioccipital and basisphenoid bone
def: "union of the basioccipital and basisphenoid bones into one structure, when this fusion does not normally occur (such as in a species where these bones normally persist as separate entities)" [https://orcid.org/0000-0003-3691-0324]
synonym: "basioccipital and basisphenoid bone fusion" EXACT []
synonym: "fused basioccipital and basisphenoid bones" EXACT []
is_a: MP:0000079 ! abnormal basioccipital bone morphology
is_a: MP:0000106 ! abnormal basisphenoid bone morphology

[Term]
id: MP:0004573
name: absent limb buds
def: "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:A16.567]
is_a: MP:0005650 ! abnormal limb bud morphology

[Term]
id: MP:0004574
name: broad limb buds
def: "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:A16.567]
synonym: "wide limb buds" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology

[Term]
id: MP:0004575
name: small limb buds
def: "reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:A16.567]
is_a: MP:0005650 ! abnormal limb bud morphology

[Term]
id: MP:0004576
name: abnormal embryonic autopod plate morphology
def: "any structural anomaly of transient  developing limb structure that forms by expansion of the distal end of the limb paddle and will give rise to the pedal appendages (e.g. hand, foot, paw)" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "abnormal foot plate morphology" NARROW []
synonym: "abnormal footplate morphology" NARROW []
synonym: "abnormal hand plate morphology" NARROW []
synonym: "abnormal handplate morphology" NARROW []
synonym: "abnormal limb plate morphology" EXACT []
is_a: MP:0006279 ! abnormal limb development

[Term]
id: MP:0004577
name: abnormal cochlear hair cell inter-stereocilial links morphology
def: "any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004521 ! abnormal cochlear hair cell stereociliary bundle morphology

[Term]
id: MP:0004578
name: abnormal cochlear hair bundle tip links morphology
def: "any structural anomaly in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004577 ! abnormal cochlear hair cell inter-stereocilial links morphology

[Term]
id: MP:0004579
name: abnormal cochlear hair bundle horizontal top connectors morphology
def: "any structural anomaly in the inter-stereocilial links that connect the top of a shorter stereocilium to an adjacent longer stereocilium at a short distance below the tip links; the appearance of horizontal top connectors, which persist into adulthood, occurs concomitant with this loss of ankle links; top connectors are essentially unaffected by treatment with subtilisin and EGTA" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004577 ! abnormal cochlear hair cell inter-stereocilial links morphology

[Term]
id: MP:0004580
name: abnormal cochlear hair bundle transient lateral links morphology
def: "any structural anomaly in the fine lateral links that interconnect stereocilia at prenatal stages; transient lateral links diminish at early postnatal stages when ankle links appear at the base of stereocilia, and are essentially unaffected by treatment with subtilisin and EGTA" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004577 ! abnormal cochlear hair cell inter-stereocilial links morphology

[Term]
id: MP:0004581
name: abnormal cochlear hair bundle ankle links morphology
def: "any structural anomaly in the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down; in the mouse, ankle links are only a transient feature of the developing cochlear hair bundles, present predominantly from P2 though P9, but are absent by P12; ankle links are disrupted by treatment of hair cells with EGTA and subtilisin but not by La3+ and elastase" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004577 ! abnormal cochlear hair cell inter-stereocilial links morphology

[Term]
id: MP:0004582
name: absent cochlear hair bundle ankle links
def: "absence of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004581 ! abnormal cochlear hair bundle ankle links morphology

[Term]
id: MP:0004583
name: abnormal vestibular hair bundle inter-stereocilial links
def: "any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of vestibular hair bundles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004515 ! abnormal vestibular hair cell stereociliary bundle morphology

[Term]
id: MP:0004584
name: abnormal vestibular hair bundle shaft connectors
def: "any structural anomaly in the links that connect the shafts of neighboring stereocilia in vestibular hair bundles; each shaft connector is composed of a ruthenium red-reactive, electron-dense particle that is connected to the plasma membrane by several fine strands of variable length" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004583 ! abnormal vestibular hair bundle inter-stereocilial links

[Term]
id: MP:0004585
name: absent vestibular hair bundle shaft connectors
def: "absence of the inter-stereocilial links that connect the shafts of neighboring stereocilia in vestibular hair bundles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004584 ! abnormal vestibular hair bundle shaft connectors

[Term]
id: MP:0004586
name: pillar cell degeneration
def: "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003825 ! abnormal pillar cell morphology

[Term]
id: MP:0004587
name: decreased cellular sensitivity to X-ray irradiation
def: "decreased incidence of cell death following exposure to X-ray irradiation" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased cellular susceptibility to X-ray irradiation" EXACT []
synonym: "increased cellular resistance to X-ray irradiation" EXACT []
synonym: "reduced cellular sensitivity to X-ray irradiation" EXACT []
is_a: MP:0004228 ! decreased cellular sensitivity to ionizing radiation

[Term]
id: MP:0004588
name: abnormal vestibular hair cell development
def: "atypical initial production, differentiation, migration or maturation of hair cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the inner ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002623 ! abnormal vestibular hair cell morphology
is_a: MP:0011238 ! abnormal inner ear development

[Term]
id: MP:0004589
name: abnormal cochlear hair cell development
def: "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory hair cell development" EXACT []
is_a: MP:0002622 ! abnormal cochlear hair cell morphology
is_a: MP:0003938 ! abnormal ear development

[Term]
id: MP:0004590
name: absent Deiters cells
def: "absence of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent phalangeal cells" EXACT []
is_a: MP:0004302 ! abnormal Deiters cell morphology

[Term]
id: MP:0004591
name: enlarged tectorial membrane
def: "increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased tectorial membrane size" EXACT []
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0004592
name: small mandible
def: "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8]
synonym: "decreased mandible size" EXACT []
synonym: "reduced mandible size" EXACT []
synonym: "small lower jaw" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology

[Term]
id: MP:0004593
name: long mandible
def: "increased length of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8]
synonym: "increased mandible length" EXACT []
is_a: MP:0030050 ! large mandible

[Term]
id: MP:0004594
name: abnormal mandibular coronoid process morphology
def: "any structural anomaly of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion); includes the attachment site to the temporal muscle" [https://orcid.org/0000-0003-3691-0324]
comment: abnormal mandible coronoid process morphology
synonym: "abnormal coronoid process of the mandible morphology" EXACT []
is_a: MP:0010150 ! abnormal mandibular ramus morphology

[Term]
id: MP:0004595
name: abnormal mandibular condyloid process morphology
def: "any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal condyloid process of the mandible morphology" EXACT []
is_a: MP:0010150 ! abnormal mandibular ramus morphology

[Term]
id: MP:0004596
name: abnormal mandibular angle morphology
def: "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal angular process of the mandible morphology" EXACT []
synonym: "abnormal gonial angle morphology" EXACT []
synonym: "abnormal mandible angular process morphology" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology

[Term]
id: MP:0004597
name: increased susceptibility to noise-induced hearing loss
def: "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to noise-induced hearing loss" EXACT []
is_a: MP:0006334 ! abnormal susceptibility to hearing loss

[Term]
id: MP:0004598
name: abnormal cochlear basement membrane morphology
def: "any structural anomaly in the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000031 ! abnormal cochlea morphology
is_a: MP:0004272 ! abnormal basement membrane morphology

[Term]
id: MP:0004599
name: abnormal vertebral arch morphology
alt_id: MP:0009730
def: "any structural anomaly of the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal dorsal arch morphology" EXACT []
synonym: "abnormal neural arch morphology" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0004600
name: abnormal vertebral transverse process morphology
def: "any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004601
name: abnormal vertebral spinous process morphology
def: "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal dorsal spine" EXACT []
synonym: "abnormal vertebral spine" EXACT []
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004602
name: abnormal vertebral articular process morphology
def: "any structural anomaly of the bilateral flat projections that arise from the junctions of the pedicles and laminae" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004603
name: absent vertebral arch
def: "loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent dorsal arch" EXACT []
synonym: "absent neural arch" EXACT []
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004604
name: abnormal vertebral pedicle morphology
def: "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004605
name: abnormal vertebral lamina morphology
def: "any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0004599 ! abnormal vertebral arch morphology

[Term]
id: MP:0004606
name: absent vertebral spinous process
def: "missing the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8]
synonym: "absent vertebral spine" EXACT []
is_a: MP:0004601 ! abnormal vertebral spinous process morphology

[Term]
id: MP:0004607
name: abnormal cervical atlas morphology
def: "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal C1 vertebra morphology" EXACT []
is_a: MP:0003048 ! abnormal cervical vertebrae morphology

[Term]
id: MP:0004608
name: abnormal cervical axis morphology
def: "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal C2 vertebra morphology" EXACT []
synonym: "abnormal epistropheus morphology" EXACT []
is_a: MP:0003048 ! abnormal cervical vertebrae morphology

[Term]
id: MP:0004609
name: vertebral fusion
def: "the union of one or more vertebrae into a single structure" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "fused vertebrae" EXACT []
synonym: "fusion of vertebrae" RELATED []
synonym: "vertebral ankylosis" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology
is_a: MP:0003189 ! fused joints

[Term]
id: MP:0004610
name: small vertebrae
def: "reduced size of the bony segments of the spinal column" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased vertebrae size" EXACT []
synonym: "reduced vertebrae size" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0004611
name: increased susceptibility to ototoxicity-induced hearing loss
def: "greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to ototoxicity-induced hearing loss" EXACT []
is_a: MP:0006334 ! abnormal susceptibility to hearing loss
is_a: MP:0008873 ! increased physiological sensitivity to xenobiotic

[Term]
id: MP:0004612
name: fusion of vertebral bodies
def: "improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal" [https://orcid.org/0000-0003-3691-0324]
synonym: "fused vertebral bodies" RELATED []
synonym: "vertebral body fusion" EXACT []
is_a: MP:0000141 ! abnormal vertebral body morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004613
name: fusion of vertebral arches
def: "improper union of the dorsal part of adjacent vertebra" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "fused vertebral arches" EXACT []
synonym: "fusion of dorsal arches" EXACT []
synonym: "fusion of neural arches" EXACT []
synonym: "vertebral arch fusion" EXACT []
is_a: MP:0004599 ! abnormal vertebral arch morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004614
name: caudal vertebral transformation
def: "homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae" [https://orcid.org/0000-0003-3691-0324]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
subset: IMPC
subset: Sanger_Terms
synonym: "caudal transitional vertebrae" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0003036 ! vertebral transformation

[Term]
id: MP:0004615
name: cervical vertebral transformation
def: "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "cervical transitional vertebrae" EXACT []
is_a: MP:0003036 ! vertebral transformation
is_a: MP:0003048 ! abnormal cervical vertebrae morphology

[Term]
id: MP:0004616
name: lumbar vertebral transformation
def: "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "lumbar transitional vertebrae" EXACT []
is_a: MP:0003036 ! vertebral transformation
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004617
name: sacral vertebral transformation
def: "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "sacral transitional vertebrae" EXACT []
is_a: MP:0003036 ! vertebral transformation
is_a: MP:0003050 ! abnormal sacral vertebrae morphology

[Term]
id: MP:0004618
name: thoracic vertebral transformation
def: "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "thoracic transitional vertebrae" RELATED []
is_a: MP:0003036 ! vertebral transformation
is_a: MP:0003047 ! abnormal thoracic vertebrae morphology

[Term]
id: MP:0004619
name: caudal vertebral fusion
def: "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [https://orcid.org/0000-0003-3691-0324]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
subset: IMPC
subset: Sanger_Terms
synonym: "caudal vertebral ankylosis" EXACT []
synonym: "fused caudal vertebrae" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004620
name: cervical vertebral fusion
def: "the union of one or more cervical vertebrae into a single structure" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "cervical vertebral ankylosis" EXACT []
synonym: "fused cervical vertebrae" EXACT []
is_a: MP:0003048 ! abnormal cervical vertebrae morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004621
name: lumbar vertebral fusion
def: "the union of one or more lumbar vertebrae into a single structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "fusion of lumbar vertebrae" EXACT []
synonym: "lumbar vertebral ankylosis" EXACT []
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004622
name: sacral vertebral fusion
def: "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [https://orcid.org/0000-0003-3691-0324]
comment: In humans, vertebrae S1-S5 are normally fused in maturity, with no intervertebral discs. In rodents, these vertebrae remain distinct in adulthood.
synonym: "fused sacral vertebrae" EXACT []
synonym: "fusion of sacral vertebrae" EXACT []
is_a: MP:0003050 ! abnormal sacral vertebrae morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004623
name: thoracic vertebral fusion
def: "the union of one or more thoracic vertebrae into a single structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "fusied thoracic vertebrae" EXACT []
synonym: "fusion of thoracic vertebrae" EXACT []
synonym: "thoracic vertebral ankylosis" EXACT []
is_a: MP:0003047 ! abnormal thoracic vertebrae morphology
is_a: MP:0004609 ! vertebral fusion

[Term]
id: MP:0004624
name: abnormal thoracic cage morphology
def: "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal rib cage morphology" EXACT []
synonym: "abnormal ribcage morphology" EXACT []
synonym: "abnormal thoracic basket morphology" EXACT []
is_a: MP:0002114 ! abnormal axial skeleton morphology

[Term]
id: MP:0004625
name: abnormal rib joint morphology
def: "any anomaly in the normal joining of the ribs to the vertebral column or to the sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal rib articulation" EXACT []
synonym: "abnormal rib attachment" EXACT []
is_a: MP:0002932 ! abnormal joint morphology
is_a: MP:0004624 ! abnormal thoracic cage morphology

[Term]
id: MP:0004626
name: vertebral compression
def: "appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0021136 ! abnormal vertebrae shape

[Term]
id: MP:0004627
name: abnormal trochanter morphology
def: "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8]
is_a: MP:0000559 ! abnormal femur morphology

[Term]
id: MP:0004628
name: Deiters cell degeneration
def: "degeneration or loss of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [https://orcid.org/0000-0002-6490-7723]
synonym: "phalangeal cell degeneration" EXACT []
is_a: MP:0004302 ! abnormal Deiters cell morphology

[Term]
id: MP:0004629
name: abnormal spiral modiolar artery morphology
def: "any structural anomaly of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0004630
name: spiral modiolar artery stenosis
def: "abnormal narrowing or constriction of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus and serves the ganglion and the cochlear duct and its contents" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004629 ! abnormal spiral modiolar artery morphology
is_a: MP:0006135 ! artery stenosis

[Term]
id: MP:0004631
name: abnormal auditory cortex morphology
def: "any structural anomaly in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000801 ! abnormal temporal lobe morphology

[Term]
id: MP:0004632
name: abnormal cochlear OHC efferent innervation pattern
def: "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology
is_a: MP:0014489 ! abnormal cochlear sensory neuron innervation pattern

[Term]
id: MP:0004633
name: abnormal cochlear IHC efferent innervation pattern
def: "any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology
is_a: MP:0014489 ! abnormal cochlear sensory neuron innervation pattern

[Term]
id: MP:0004634
name: short metacarpal bones
def: "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "reduced length of metacarpal bones" EXACT []
is_a: MP:0003073 ! abnormal metacarpal bone morphology
is_a: MP:0004686 ! decreased length of long bones

[Term]
id: MP:0004635
name: short metatarsal bones
def: "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "reduced length of metatarsal bones" EXACT []
is_a: MP:0003072 ! abnormal metatarsal bone morphology
is_a: MP:0004686 ! decreased length of long bones

[Term]
id: MP:0004636
name: decreased metacarpal bone number
def: "reduced number of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "decreased number of metacarpal bones" EXACT []
synonym: "reduced metacarpal bone number" RELATED []
is_a: MP:0003073 ! abnormal metacarpal bone morphology

[Term]
id: MP:0004637
name: metacarpal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the metacarpal bones, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic metacarpal bones" EXACT []
is_a: MP:0003073 ! abnormal metacarpal bone morphology

[Term]
id: MP:0004638
name: elongated metacarpal bones
def: "increased length of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8]
is_a: MP:0003073 ! abnormal metacarpal bone morphology
is_a: MP:0004695 ! increased length of long bones

[Term]
id: MP:0004639
name: fused metacarpal bones
def: "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "fusion of metacarpal bones" EXACT []
synonym: "metacarpal bone fusion" EXACT []
is_a: MP:0003073 ! abnormal metacarpal bone morphology

[Term]
id: MP:0004640
name: decreased metatarsal bone number
def: "reduced number of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "decreased number of metatarsal bones" EXACT []
synonym: "reduced metatarsal bone number" EXACT []
is_a: MP:0003072 ! abnormal metatarsal bone morphology

[Term]
id: MP:0004641
name: elongated metatarsal bones
def: "increased length of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8]
is_a: MP:0003072 ! abnormal metatarsal bone morphology
is_a: MP:0004695 ! increased length of long bones

[Term]
id: MP:0004642
name: fused metatarsal bones
def: "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8]
synonym: "fusion of metatarsal bones" EXACT []
synonym: "metatarsal bone fusion" EXACT []
is_a: MP:0003072 ! abnormal metatarsal bone morphology

[Term]
id: MP:0004643
name: abnormal vertebrae number
def: "altered number of the bony segments of the spinal column" [ISBN:0-683-40008-8]
synonym: "abnormal number of vertebrae" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0004644
name: increased vertebrae number
def: "an increase over the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8]
synonym: "increased number of vertebrae" RELATED []
synonym: "supernumerary vertebrae" EXACT []
is_a: MP:0004643 ! abnormal vertebrae number

[Term]
id: MP:0004645
name: decreased vertebrae number
def: "a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8]
synonym: "decreased number of vertebrae" EXACT []
synonym: "reduced number of vertebrae" EXACT []
synonym: "reduced vertebrae number" EXACT []
is_a: MP:0004643 ! abnormal vertebrae number

[Term]
id: MP:0004646
name: decreased cervical vertebrae number
def: "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of cervical vertebrae" EXACT []
synonym: "reduced cervical vertebrae number" EXACT []
synonym: "reduced number of cervical vertebrae" EXACT []
is_a: MP:0000461 ! decreased presacral vertebrae number
is_a: MP:0003048 ! abnormal cervical vertebrae morphology

[Term]
id: MP:0004647
name: decreased lumbar vertebrae number
def: "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:A02.835.232.834.519]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of lumbar vertebrae" EXACT []
synonym: "reduced lumbar vertebrae number" EXACT []
is_a: MP:0000461 ! decreased presacral vertebrae number
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004648
name: decreased thoracic vertebrae number
def: "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:A02.835.232.834.892]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of thoracic vertebrae" RELATED []
synonym: "reduced thoracic vertebrae number" EXACT []
is_a: MP:0000461 ! decreased presacral vertebrae number
is_a: MP:0003047 ! abnormal thoracic vertebrae morphology

[Term]
id: MP:0004649
name: decreased sacral vertebrae number
def: "reduced number of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of sacral vertebrae" RELATED []
synonym: "reduced sacral vertebrae number" EXACT []
is_a: MP:0003050 ! abnormal sacral vertebrae morphology
is_a: MP:0004645 ! decreased vertebrae number

[Term]
id: MP:0004650
name: increased lumbar vertebrae number
def: "increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:A02.835.232.834.519]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased number of lumbar vertebrae" EXACT []
is_a: MP:0000464 ! increased presacral vertebrae number
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004651
name: increased thoracic vertebrae number
def: "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:A02.835.232.834.892]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased number of thoracic vertebrae" EXACT []
is_a: MP:0000464 ! increased presacral vertebrae number
is_a: MP:0003047 ! abnormal thoracic vertebrae morphology

[Term]
id: MP:0004652
name: small caudal vertebrae
def: "reduced size of the bony segments of the coccyx or tail" [https://orcid.org/0000-0003-3691-0324]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
is_a: MP:0002759 ! abnormal caudal vertebrae morphology

[Term]
id: MP:0004653
name: absent caudal vertebrae
def: "absence of all of the bony segments of the coccyx or tail" [https://orcid.org/0000-0003-3691-0324]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
is_a: MP:0002759 ! abnormal caudal vertebrae morphology

[Term]
id: MP:0004654
name: absent lumbar vertebrae
def: "absence of all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:A02.835.232.834.519]
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004655
name: absent thoracic vertebrae
def: "absence of all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:A02.835.232.834.892]
is_a: MP:0003047 ! abnormal thoracic vertebrae morphology

[Term]
id: MP:0004656
name: absent sacral vertebrae
def: "absence of all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003050 ! abnormal sacral vertebrae morphology

[Term]
id: MP:0004657
name: small sacral vertebrae
def: "reduced size of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased sacral vertebra size" EXACT []
synonym: "reduced sacral vertebra size" EXACT []
is_a: MP:0003050 ! abnormal sacral vertebrae morphology

[Term]
id: MP:0004658
name: abnormal ventral tubercle of atlas morphology
def: "any structural anomaly of the conical ventral projection on the arch of the atlas" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004607 ! abnormal cervical atlas morphology

[Term]
id: MP:0004659
name: abnormal odontoid process morphology
def: "any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8, MESH:A02.835.232.834.151.383.668]
synonym: "abnormal dens morphology" EXACT []
synonym: "abnormal odontoid peg morphology" EXACT []
is_a: MP:0004608 ! abnormal cervical axis morphology

[Term]
id: MP:0004660
name: absent thyroid follicular cells
def: "absence of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004697 ! abnormal thyroid follicular cell morphology

[Term]
id: MP:0004661
name: absent thyroid parafollicular C-cells
def: "absence of the neuroepithelial secretory cells that occur singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid; these cells secrete calcitonin, 5-hydroxytryptamine and dopamine" [CL:0000570, https://orcid.org/0000-0002-6490-7723]
synonym: "absent C cells" EXACT []
synonym: "absent C cells of thyroid gland" EXACT []
synonym: "absent clear cells of thyroid gland" EXACT []
synonym: "absent parafollicular cells of thyroid gland" EXACT []
synonym: "absent thyroid clear cells" EXACT []
synonym: "absent thyroid parafollicular cells" EXACT []
is_a: MP:0004698 ! abnormal thyroid parafollicular C-cell morphology

[Term]
id: MP:0004662
name: abnormal thyroid diverticulum morphology
def: "any structural anomaly in the endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003421 ! abnormal thyroid gland development

[Term]
id: MP:0004663
name: athyroidism
def: "congenital absence of the thyroid gland or suppression or absence of its hormonal secretion" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0004664
name: delayed inner ear development
def: "slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011238 ! abnormal inner ear development

[Term]
id: MP:0004665
name: abnormal stapedial artery morphology
def: "any structural anomaly in the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000049 ! abnormal middle ear morphology
is_a: MP:0014012 ! abnormal cranial blood vasculature morphology

[Term]
id: MP:0004666
name: absent stapedial artery
def: "absence of the small artery that passes through the ring of the stapes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004665 ! abnormal stapedial artery morphology

[Term]
id: MP:0004667
name: vertebral body hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the vertebral body, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic vertebral body" EXACT []
is_a: MP:0004670 ! small vertebral body

[Term]
id: MP:0004668
name: absent vertebral body
def: "absence of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8]
is_a: MP:0000141 ! abnormal vertebral body morphology

[Term]
id: MP:0004669
name: enlarged vertebral body
def: "increased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8]
synonym: "increased vertebral body size" EXACT []
is_a: MP:0000141 ! abnormal vertebral body morphology

[Term]
id: MP:0004670
name: small vertebral body
def: "decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8]
synonym: "decreased vertebral body size" EXACT []
synonym: "reduced vertebral body size" EXACT []
is_a: MP:0000141 ! abnormal vertebral body morphology

[Term]
id: MP:0004671
name: long ribs
def: "increased length of the bones forming the bony wall of the chest" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased rib length" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004672
name: short ribs
def: "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8]
synonym: "decreased rib length" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004673
name: splayed ribs
def: "any deviation from the normal curvature of the ribs such that the ribs are turned outward" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004674
name: thin ribs
def: "a more slender appearance of the bones forming the bony wall of the chest" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "gracile ribs" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004675
name: rib fractures
def: "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8]
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004676
name: wide ribs
def: "an increase in the width of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8]
synonym: "broad ribs" EXACT []
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004677
name: truncated ribs
def: "ribs that terminate abruptly as if having an end or point cut off" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0004678
name: split xiphoid process
def: "the appearance of an abnormal division of the caudal tip of the sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "bifid xiphoid process" EXACT []
is_a: MP:0000159 ! abnormal xiphoid process morphology

[Term]
id: MP:0004679
name: xiphoid process foramen
def: "the appearance of a hole or holes in the caudal tip of the sternum" [ISBN:0-683-40008-8]
is_a: MP:0000159 ! abnormal xiphoid process morphology

[Term]
id: MP:0004680
name: small xiphoid process
def: "reduced size of the caudal tip of the sternum" [ISBN:0-683-40008-8]
is_a: MP:0000159 ! abnormal xiphoid process morphology

[Term]
id: MP:0004681
name: intervertebral disk hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the intervertebral disk, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "hypoplastic intervertebral disk" EXACT []
synonym: "intervertebral disc hypoplasia" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004682 ! small intervertebral disk

[Term]
id: MP:0004682
name: small intervertebral disk
def: "reduced size of the cartilaginous and gelatinous structure found between vertebrae" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "small intervertebral disc" EXACT []
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0004683
name: absent intervertebral disk
def: "absence of the cartilaginous and gelatinous structure found between vertebrae" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "absent intervertebral disc" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0004684
name: intervertebral disk degeneration
def: "retrogressive pathological change of the cartilaginous and gelatinous structure found between vertebrae" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "intervertebral disc degeneration" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "spondylosis" EXACT []
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0004685
name: calcified intervertebral disk
def: "pathologic deposition of calcium salts in one or more intervertebral disks" [https://orcid.org/0000-0002-6490-7723]
synonym: "calcified intervertebral disc" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "calcified intervertebral discs" EXACT []
synonym: "calcified intervertebral disks" EXACT []
synonym: "intervertebral calcification" BROAD []
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0004686
name: decreased length of long bones
def: "reduced end-to-end length of the several elongated bones of the extremities" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced length of long bones" EXACT []
synonym: "short long bones" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0004687
name: split vertebrae
def: "any vertebrae or vertebral section that is cleft into two parts" [https://orcid.org/0000-0003-3691-0324]
synonym: "bifid vertebrae" EXACT []
synonym: "cleft vertebrae" EXACT []
synonym: "splayed vertebrae" NARROW []
is_a: MP:0021136 ! abnormal vertebrae shape

[Term]
id: MP:0004688
name: absent ilium
def: "absence of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis" [ISBN:0-683-40008-8]
is_a: MP:0005354 ! abnormal ilium morphology

[Term]
id: MP:0004689
name: small ischium
def: "reduced size of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [https://orcid.org/0009-0005-7755-8314]
synonym: "small ischium bone" RELATED []
is_a: MP:0004507 ! abnormal ischium morphology

[Term]
id: MP:0004690
name: ischium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ischium, typically resulting in decreased size" [https://orcid.org/0009-0005-7755-8314]
synonym: "hypoplastic ischium" EXACT []
synonym: "ischium bone hypoplasia" EXACT []
is_a: MP:0004689 ! small ischium

[Term]
id: MP:0004691
name: absent pubis
def: "absence of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [https://orcid.org/0009-0005-7755-8314]
synonym: "absent pubic bone" EXACT []
is_a: MP:0004506 ! abnormal pubis morphology

[Term]
id: MP:0004692
name: small pubis
def: "reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [https://orcid.org/0009-0005-7755-8314]
synonym: "small pubic bone" RELATED []
is_a: MP:0004506 ! abnormal pubis morphology

[Term]
id: MP:0004693
name: pubis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pubis, typically resulting in decreased size" [https://orcid.org/0009-0005-7755-8314]
synonym: "hypoplastic pubis" EXACT []
synonym: "pubic bone hypoplasia" EXACT []
is_a: MP:0004692 ! small pubis

[Term]
id: MP:0004694
name: absent patella
def: "absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8]
is_a: MP:0005353 ! abnormal patella morphology

[Term]
id: MP:0004695
name: increased length of long bones
def: "greater end-to-end length of the several elongated bones of the extremities" [https://orcid.org/0000-0003-3691-0324]
synonym: "long long bones" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0004696
name: abnormal thyroid follicle morphology
def: "any structural anomaly of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8]
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0004697
name: abnormal thyroid follicular cell morphology
def: "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal thyrocyte morphology" EXACT []
synonym: "abnormal thyroid principal cell morphology" EXACT []
is_a: MP:0004696 ! abnormal thyroid follicle morphology

[Term]
id: MP:0004698
name: abnormal thyroid parafollicular C-cell morphology
def: "any structural anomaly of the neuroepithelial secretory cells that occur singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid; these cells secrete calcitonin, 5-hydroxytryptamine and dopamine" [CL:0000570, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal C cell morphology" EXACT []
synonym: "abnormal C cell of thyroid gland morphology" EXACT []
synonym: "abnormal clear cell of thyroid gland morphology" EXACT []
synonym: "abnormal parafollicular cell of thyroid gland morphology" EXACT []
synonym: "abnormal thyroid clear cell morphology" EXACT []
synonym: "abnormal thyroid parafollicular C-cells" BROAD []
synonym: "abnormal thyroid parafollicular cell morphology" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0004699
name: unilateral deafness
def: "bilateral asymmetry in auditory function whereby one of the two ears displays auditory thresholds indicative of intact hearing while the other ear displays thresholds reflecting auditory dysfunction" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0004700
name: abnormal circulating insulin-like growth factor I level
def: "anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [https://orcid.org/0000-0003-3691-0324, MESH:D12.644.276.937.400]
synonym: "abnormal circulating IGF-I level" EXACT []
synonym: "abnormal circulating IGF1 level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0008831 ! abnormal insulin-like growth factor I level

[Term]
id: MP:0004701
name: decreased circulating insulin-like growth factor I level
def: "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced circulating insulin-like growth factor I level" EXACT []
is_a: MP:0004700 ! abnormal circulating insulin-like growth factor I level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0004702
name: increased circulating insulin-like growth factor I level
def: "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004700 ! abnormal circulating insulin-like growth factor I level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0004703
name: abnormal vertebral column morphology
def: "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal backbone morphology" EXACT []
synonym: "abnormal spinal column morphology" EXACT []
synonym: "abnormal spine morphology" EXACT []
is_a: MP:0002114 ! abnormal axial skeleton morphology

[Term]
id: MP:0004704
name: short vertebral column
def: "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased vertebral column length" EXACT []
synonym: "short spinal axis" EXACT []
synonym: "short spinal column" EXACT []
synonym: "short spine" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology

[Term]
id: MP:0004705
name: elongated vertebral body
def: "increased length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8]
synonym: "increased vertebral body length" EXACT []
is_a: MP:0000141 ! abnormal vertebral body morphology

[Term]
id: MP:0004706
name: short vertebral body
def: "reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8]
synonym: "decreased vertebral body length" EXACT []
synonym: "reduced vertebral body length" EXACT []
is_a: MP:0004670 ! small vertebral body

[Term]
id: MP:0004707
name: enlarged lumbar vertebrae
def: "increased size of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lumbar vertebra size" EXACT []
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004708
name: short lumbar vertebrae
def: "reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lumbar vertebra length" EXACT []
synonym: "reduced lumbar vertebra length" EXACT []
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology

[Term]
id: MP:0004709
name: cervical vertebrae degeneration
def: "retrogressive pathologic change of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [https://orcid.org/0000-0003-3691-0324, MESH:A02.835.232.834.151]
is_a: MP:0003048 ! abnormal cervical vertebrae morphology

[Term]
id: MP:0004710
name: small notochord
def: "reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8]
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0004711
name: persistence of notochord tissue
def: "failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen" [https://orcid.org/0000-0003-3691-0324]
synonym: "lack of notochord regression" EXACT []
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0004712
name: notochord degeneration
def: "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8]
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0004713
name: split notochord
def: "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8]
synonym: "bifid notochord" EXACT []
synonym: "bifurcated notochord" EXACT []
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0004714
name: truncated notochord
def: "notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8]
is_a: MP:0002825 ! abnormal notochord morphology

[Term]
id: MP:0004715
name: absent vestibulocochlear nerve
def: "absence of the composite sensory nerve innervating the receptor cells of the membranous labyrinth" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent eighth cranial nerve [CN VIII]" EXACT []
synonym: "absent eighth nerve" EXACT []
synonym: "absent nervus acusticus [CN VIII]" EXACT []
synonym: "absent nervus octavus [CN VIII]" EXACT []
synonym: "absent nervus statoacusticus [CN VIII]" EXACT []
synonym: "absent nervus vestibulocochlearis [CN VIII]" EXACT []
synonym: "absent octavus" EXACT []
synonym: "absent statoacoustic nerve" EXACT []
is_a: MP:0001072 ! abnormal vestibulocochlear nerve morphology

[Term]
id: MP:0004716
name: abnormal cochlear nerve morphology
def: "any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auditory nerve morphology" EXACT []
synonym: "abnormal cochlear part of vestibulocochlear nerve morphology" EXACT []
synonym: "abnormal inferior part of vestibulocochlear nerve morphology" EXACT []
synonym: "abnormal nervus cochlearis morphology" EXACT []
synonym: "abnormal pars cochlearis nervi vestibulocochlearis morphology" EXACT []
is_a: MP:0001072 ! abnormal vestibulocochlear nerve morphology

[Term]
id: MP:0004717
name: absent cochlear nerve
def: "absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the cochlear root" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory nerve" EXACT []
synonym: "absent cochlear part of vestibulocochlear nerve" EXACT []
synonym: "absent inferior part of vestibulocochlear nerve" EXACT []
synonym: "absent nervus cochlearis" EXACT []
synonym: "absent pars cochlearis nervi vestibulocochlearis" EXACT []
is_a: MP:0004716 ! abnormal cochlear nerve morphology

[Term]
id: MP:0004718
name: abnormal vestibular nerve morphology
def: "any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal nervus vestibularis morphology" EXACT []
synonym: "abnormal pars vestibularis nervi vestibulocochlearis morphology" EXACT []
synonym: "abnormal superior part of vestibulocochlear nerve morphology" EXACT []
synonym: "abnormal vestibular part of vestibulocochlear nerve morphology" EXACT []
synonym: "abnormal vestibular root of cranial nerve VIII morphology" EXACT []
is_a: MP:0001072 ! abnormal vestibulocochlear nerve morphology

[Term]
id: MP:0004719
name: absent vestibular nerve
def: "absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the vestibular root" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent nervus vestibularis" EXACT []
synonym: "absent pars vestibularis nervi vestibulocochlearis" EXACT []
synonym: "absent superior part of vestibulocochlear nerve" EXACT []
synonym: "absent vestibular part of vestibulocochlear nerve" EXACT []
synonym: "absent vestibular root of cranial nerve VIII" EXACT []
is_a: MP:0004718 ! abnormal vestibular nerve morphology

[Term]
id: MP:0004720
name: abnormal platelet morphology
def: "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:A11.118.188]
synonym: "abnormal blood platelet morphology" RELATED [MESH:A11.118.188]
synonym: "abnormal platelets morphology" EXACT []
synonym: "abnormal thrombocyte morphology" EXACT [MESH:A11.118.188]
synonym: "platelet dysplasia" NARROW [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013657 ! abnormal blood cell morphology
is_a: MP:0013658 ! abnormal myeloid cell morphology

[Term]
id: MP:0004721
name: abnormal platelet dense granule morphology
def: "any structural anomaly of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [MGI:llw2]
synonym: "abnormal platelet delta granule morphology" EXACT []
synonym: "abnormal platelet delta-granule morphology" EXACT []
synonym: "abnormal platelet dense body morphology" EXACT []
synonym: "abnormal thrombocyte dense granule morphology" EXACT []
is_a: MP:0004720 ! abnormal platelet morphology

[Term]
id: MP:0004722
name: abnormal platelet dense granule number
def: "altered number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [MGI:llw2]
synonym: "abnormal number of platelet dense granules" RELATED []
synonym: "abnormal platelet delta granule number" EXACT []
synonym: "abnormal platelet delta-granule number" EXACT []
synonym: "abnormal thrombocyte dense granule number" EXACT []
is_a: MP:0004721 ! abnormal platelet dense granule morphology

[Term]
id: MP:0004723
name: abnormal platelet serotonin level
def: "anomaly in the amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [MESH:D02.092.211.215.801.852]
synonym: "abnormal platelet 5-HT level" EXACT []
synonym: "abnormal platelet 5-hydroxytryptamine level" EXACT []
synonym: "abnormal platelet enteramine level" EXACT []
synonym: "abnormal platelet hippophaine level" EXACT []
synonym: "abnormal platelet hydroxytryptamine level" EXACT []
is_a: MP:0004721 ! abnormal platelet dense granule morphology
is_a: MP:0005322 ! abnormal serotonin level

[Term]
id: MP:0004724
name: increased platelet serotonin level
def: "greater than normal amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8, MESH:D02.092.211.215.801.852]
synonym: "increased platelet 5-HT level" EXACT []
synonym: "increased platelet 5-hydroxytryptamine level" EXACT []
synonym: "increased platelet enteramine level" EXACT []
synonym: "increased platelet hippophaine level" EXACT []
synonym: "increased platelet hydroxytryptamine level" EXACT []
is_a: MP:0004723 ! abnormal platelet serotonin level
is_a: MP:0010069 ! increased serotonin level

[Term]
id: MP:0004725
name: decreased platelet serotonin level
def: "reduced amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8, MESH:D02.092.211.215.801.852]
synonym: "decreased platelet 5-HT level" EXACT []
synonym: "decreased platelet 5-hydroxytryptamine level" EXACT []
synonym: "decreased platelet enteramine level" EXACT []
synonym: "decreased platelet hippophaine level" EXACT []
synonym: "decreased platelet hydroxytryptamine level" EXACT []
synonym: "reduced platelet serotonin level" EXACT []
is_a: MP:0004723 ! abnormal platelet serotonin level
is_a: MP:0010070 ! decreased serotonin level

[Term]
id: MP:0004726
name: abnormal nasal capsule morphology
def: "any structural anomaly in the cartilage around the developing nasal cavity of the embryo" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003935 ! abnormal craniofacial development
is_a: MP:0031449 ! abnormal nasal cartilage morphology

[Term]
id: MP:0004727
name: absent epididymis
def: "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0004728
name: abnormal efferent ductules of testis morphology
def: "any structural anomaly in the small seminal ducts that lead from the testis to the head of the epididymis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ductuli efferentes testis" EXACT []
synonym: "abnormal efferent duct" EXACT []
synonym: "abnormal vas efferens" EXACT []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0004729
name: absent efferent ductules of testis
def: "absence of the small seminal ducts that lead from the testis to the head of the epididymis" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ductuli efferentes testis" EXACT []
synonym: "absent efferent duct" EXACT []
synonym: "absent vas efferens" EXACT []
is_a: MP:0004728 ! abnormal efferent ductules of testis morphology

[Term]
id: MP:0004730
name: abnormal circulating gastrin level
def: "anomalous concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8]
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0004731
name: increased circulating gastrin level
def: "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8]
synonym: "hypergastrinaemia" EXACT []
synonym: "hypergastrinemia" EXACT []
is_a: MP:0004730 ! abnormal circulating gastrin level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0004732
name: decreased circulating gastrin level
def: "reduced concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8]
synonym: "hypogastrinaemia" EXACT []
synonym: "hypogastrinemia" EXACT []
synonym: "reduced circulating gastrin level" EXACT []
is_a: MP:0004730 ! abnormal circulating gastrin level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0004733
name: abnormal thoracic cavity morphology
def: "any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal rib cavity" EXACT []
is_a: MP:0004134 ! abnormal chest morphology

[Term]
id: MP:0004734
name: small thoracic cavity
def: "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased thoracic cavity size" EXACT []
synonym: "reduced thoracic cavity size" EXACT []
is_a: MP:0004733 ! abnormal thoracic cavity morphology

[Term]
id: MP:0004735
name: enlarged thoracic cavity
def: "increased size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased thoracic cavity size" EXACT []
is_a: MP:0004733 ! abnormal thoracic cavity morphology

[Term]
id: MP:0004736
name: abnormal distortion product otoacoustic emission
def: "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http\://www.emedicine.com/ent/topic372.htm, https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal DPOAE(s)" EXACT []
is_a: MP:0006336 ! abnormal otoacoustic response

[Term]
id: MP:0004737
name: absent distortion product otoacoustic emissions
def: "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent DPOAEs" EXACT []
is_a: MP:0004736 ! abnormal distortion product otoacoustic emission

[Term]
id: MP:0004738
name: abnormal auditory brainstem response
def: "anomaly in the electrical activity generated in the ascending auditory system in response to short tone bursts; may be used to evaluate sensorineural hearing function; measurements may include the amplitude (the number of neurons firing), latency (the speed of transmission), interpeak latency (the time between peaks), interaural latency (the difference in wave V latency between ears) and threshold" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal ABRs" EXACT []
synonym: "abnormal BAEP(s)" EXACT []
synonym: "abnormal brainstem auditory brainstem response(s)" EXACT []
synonym: "abnormal brainstem auditory evoked potential" EXACT []
synonym: "abnormal brainstem evoked responses" EXACT []
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0004739
name: conductive hearing loss
alt_id: MP:0004291
def: "progressive hearing loss due to lesions in the external auditory canal or middle ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal middle-ear sound conduction" EXACT []
is_a: MP:0006326 ! conductive hearing impairment

[Term]
id: MP:0004740
name: sensorineural hearing loss
def: "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006329 ! sensorineural hearing impairment

[Term]
id: MP:0004741
name: mixed hearing loss
def: "progressive reduction in the ability to hear resulting from a combination of conductive and sensorineural hearing loss" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006327 ! mixed hearing impairment

[Term]
id: MP:0004742
name: abnormal vestibular system physiology
def: "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may result in impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0004743
name: abnormal vestibular evoked myogenic potential
def: "anomaly in the biphasic response elicited by loud clicks or tone bursts recorded from the tonically contracted sternocleidomastoid muscle; normally, acoustic stimulation of the saccule gives rise to a vestibulocollic reflex, the output of which can be measured in the neck as inhibition of activity in the ipsilateral sternocleidomastoid muscle; VEMP testing provides diagnostic information about saccular and/or inferior vestibular nerve function (assessment of balance disorders)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal VEMP(s)" EXACT []
is_a: MP:0004742 ! abnormal vestibular system physiology

[Term]
id: MP:0004744
name: reduced vestibular evoked myogenic potential
def: "reduction of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004743 ! abnormal vestibular evoked myogenic potential

[Term]
id: MP:0004745
name: absent vestibular evoked myogenic potential
def: "absence of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004743 ! abnormal vestibular evoked myogenic potential

[Term]
id: MP:0004746
name: abnormal cochlear IHC afferent innervation pattern
def: "any changes in the placement, morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004393 ! abnormal cochlear inner hair cell morphology
is_a: MP:0014489 ! abnormal cochlear sensory neuron innervation pattern

[Term]
id: MP:0004747
name: abnormal cochlear OHC afferent innervation pattern
def: "any changes in the morphology, placement or number of afferent terminals and/or their synapses in the cochlear OHC region" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004399 ! abnormal cochlear outer hair cell morphology
is_a: MP:0014489 ! abnormal cochlear sensory neuron innervation pattern

[Term]
id: MP:0004748
name: increased susceptibility to age-related hearing loss
def: "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to age-related hearing loss" EXACT []
synonym: "decreased resistance to presbyacousia" EXACT []
synonym: "decreased resistance to presbyacusis" EXACT []
synonym: "decreased resistance to presbycusis" EXACT []
synonym: "increased susceptibility to presbyacousia" EXACT []
synonym: "increased susceptibility to presbyacusis" EXACT []
synonym: "increased susceptibility to presbycusis" EXACT []
is_a: MP:0006334 ! abnormal susceptibility to hearing loss

[Term]
id: MP:0004749
name: nonsyndromic hearing loss
def: "a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006328 ! nonsyndromic hearing impairment

[Term]
id: MP:0004750
name: syndromic hearing loss
def: "a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006330 ! syndromic hearing impairment

[Term]
id: MP:0004751
name: increased length of allograft survival
def: "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005671 ! abnormal response to transplant

[Term]
id: MP:0004752
name: decreased length of allograft survival
def: "compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced length of allograft survival" EXACT []
is_a: MP:0005671 ! abnormal response to transplant

[Term]
id: MP:0004753
name: abnormal miniature excitatory postsynaptic currents
def: "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mEPSCs" EXACT []
synonym: "abnormal miniature excitatory post-synaptic currents" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0004754
name: abnormal kidney collecting duct morphology
def: "any structural anomaly of the kidney ducts lined by simple cuboidal epithelium that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance; each cortical collecting duct joints with other ducts to make a medullary connecting duct, which eventually drains into a papillary duct, emptying urine into the renal pelvis for drainage into the ureter" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal collecting tubule morphology" EXACT []
synonym: "abnormal kidney collecting tube morphology" EXACT []
synonym: "abnormal kidney collecting tubule morphology" EXACT []
synonym: "abnormal renal collecting duct morphology" EXACT []
synonym: "abnormal renal collecting tube morphology" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0004755
name: abnormal loop of Henle morphology
def: "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ansa nephroni morphology" EXACT []
synonym: "abnormal Henle's loop morphology" RELATED []
synonym: "abnormal limb of Henle" EXACT []
synonym: "abnormal nephron loop morphology" RELATED []
xref: MA:0001675
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0004756
name: abnormal proximal convoluted tubule morphology
def: "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes; the most distinctive characteristic of the proximal tubule is its brush border (or striated border), not found in the distal convoluted tubule" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal proximal kidney tubule" EXACT []
synonym: "abnormal proximal renal tubule" EXACT []
synonym: "abnormal proximal tubule" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0004757
name: abnormal distal convoluted tubule morphology
def: "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002703 ! abnormal renal tubule morphology

[Term]
id: MP:0004758
name: absent strial marginal cells
def: "absence or loss of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004366 ! abnormal strial marginal cell morphology

[Term]
id: MP:0004759
name: decreased mitotic index
def: "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
synonym: "reduced mitotic index" EXACT []
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0004760
name: increased mitotic index
def: "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0004761
name: increased susceptibility to induced pancreatitis
def: "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [https://orcid.org/0000-0003-3691-0324, MGI:hdene]
synonym: "decreased resistance to induced pancreatitis" EXACT []
is_a: MP:0001869 ! pancreas inflammation

[Term]
id: MP:0004762
name: increased anti-double stranded DNA antibody level
def: "increase in the level of antibodies that recognize double stranded DNA" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased dsDNA antibody level" EXACT []
is_a: MP:0004794 ! increased anti-nuclear antigen antibody level

[Term]
id: MP:0004763
name: obsolete absent brainstem auditory evoked potential
def: "absence of the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ABRs" EXACT []
synonym: "absent BAEP(s)" EXACT []
synonym: "absent brainstem auditory brainstem response(s)" EXACT []
synonym: "absent brainstem evoked responses" EXACT []
is_obsolete: true
replaced_by: MP:0011967

[Term]
id: MP:0004764
name: obsolete increased brainstem auditory evoked potential
def: "greater synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; decreases in auditory thresholds required to generate a response may indicate a increased potential" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ABR threshold" NARROW []
synonym: "increased ABR amplitude" NARROW []
synonym: "increased ABRs" EXACT []
synonym: "increased BAEP(s)" EXACT []
synonym: "increased brainstem auditory brainstem response(s)" EXACT []
synonym: "increased brainstem evoked responses" EXACT []
is_obsolete: true

[Term]
id: MP:0004765
name: obsolete decreased brainstem auditory evoked potential
def: "reduction in the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; increases in auditory thresholds required to generate a response may indicate a decreased potential" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ABR amplitude" NARROW []
synonym: "decreased ABRs" EXACT []
synonym: "decreased BAEP(s)" EXACT []
synonym: "decreased brainstem auditory brainstem response(s)" EXACT []
synonym: "decreased brainstem evoked responses" EXACT []
synonym: "increased ABR threshold" NARROW []
synonym: "reduced ABRs" EXACT []
synonym: "reduced BAEP(s)" EXACT []
synonym: "reduced brainstem auditory evoked potential" EXACT []
is_obsolete: true

[Term]
id: MP:0004766
name: decreased susceptibility to age-related hearing loss
def: "less than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to age-related hearing loss" EXACT []
is_a: MP:0006334 ! abnormal susceptibility to hearing loss

[Term]
id: MP:0004767
name: increased cochlear nerve compound action potential
def: "greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased auditory nerve compound action potential" RELATED []
is_a: MP:0004415 ! abnormal cochlear nerve compound action potential

[Term]
id: MP:0004768
name: abnormal axonal transport
def: "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004811 ! abnormal neuron physiology

[Term]
id: MP:0004769
name: abnormal synaptic vesicle morphology
def: "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neurotransmitter vesicle" EXACT []
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0004770
name: abnormal synaptic vesicle recycling
def: "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004811 ! abnormal neuron physiology

[Term]
id: MP:0004771
name: increased anti-single stranded DNA antibody level
def: "increase in the level of antibodies that recognize single stranded DNA" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased anti-ssDNA antibody level" EXACT []
is_a: MP:0004794 ! increased anti-nuclear antigen antibody level

[Term]
id: MP:0004772
name: abnormal bile secretion
def: "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003252 ! abnormal bile duct physiology
is_a: MP:0005085 ! abnormal gallbladder physiology

[Term]
id: MP:0004773
name: abnormal bile composition
def: "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0005085 ! abnormal gallbladder physiology

[Term]
id: MP:0004774
name: abnormal bile salt level
alt_id: MP:0005086
def: "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [https://orcid.org/0000-0003-3691-0324, MESH:D04.808.105]
synonym: "abnormal bile acid level" RELATED []
synonym: "abnormal bile amount" EXACT []
synonym: "abnormal bile volume" NARROW []
is_a: MP:0001547 ! abnormal lipid level
is_a: MP:0005365 ! abnormal bile salt homeostasis

[Term]
id: MP:0004775
name: abnormal vestibular dark cell morphology
def: "any structural anomaly in the nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high potassium ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000034 ! abnormal inner ear vestibule morphology

[Term]
id: MP:0004776
name: vestibular dark cell degeneration
def: "degeneration or loss of the nonsensory epithelial cells that lie adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004775 ! abnormal vestibular dark cell morphology

[Term]
id: MP:0004777
name: abnormal phospholipid level
def: "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0004778
name: increased macrophage derived foam cell number
def: "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
synonym: "increased foam cell number" BROAD []
synonym: "increased number of foam cells" BROAD []
xref: CL:0000517
is_a: MP:0005425 ! increased macrophage cell number
is_a: MP:0008243 ! abnormal macrophage derived foam cell morphology
is_a: MP:0009841 ! foam cell reticulosis

[Term]
id: MP:0004780
name: abnormal surfactant secretion
alt_id: MP:0004779
def: "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal production of surfactant" EXACT []
is_a: MP:0004782 ! abnormal surfactant physiology

[Term]
id: MP:0004781
name: abnormal surfactant composition
def: "anomaly in the chemical constituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004782 ! abnormal surfactant physiology

[Term]
id: MP:0004782
name: abnormal surfactant physiology
def: "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0004783
name: abnormal cardinal vein morphology
def: "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003411 ! abnormal vein development

[Term]
id: MP:0004784
name: abnormal anterior cardinal vein morphology
def: "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8]
is_a: MP:0004783 ! abnormal cardinal vein morphology

[Term]
id: MP:0004785
name: abnormal posterior cardinal vein morphology
def: "any structural anomaly of the two paired veins draining the caudal part of the body" [ISBN:0-683-40008-8]
is_a: MP:0004783 ! abnormal cardinal vein morphology

[Term]
id: MP:0004786
name: abnormal common cardinal vein morphology
def: "any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart" [ISBN:0-683-40008-8]
synonym: "abnormal Cuvier duct morphology" EXACT []
synonym: "abnormal duct of Cuvier" EXACT []
is_a: MP:0004783 ! abnormal cardinal vein morphology

[Term]
id: MP:0004787
name: abnormal dorsal aorta morphology
def: "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3]
synonym: "abnormal embryonic dorsal aorta morphology" EXACT []
is_a: MP:0003410 ! abnormal artery development

[Term]
id: MP:0004788
name: abnormal auditory cortex tonotopy
def: "any abnormality in the spatial arrangement of structures that subserve various frequencies in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004631 ! abnormal auditory cortex morphology

[Term]
id: MP:0004789
name: increased bile salt level
def: "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [https://orcid.org/0000-0003-3691-0324, MESH:D04.808.105]
synonym: "increased bile acid level" EXACT []
is_a: MP:0004774 ! abnormal bile salt level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0004790
name: absent upper incisors
def: "absence of the upper pair of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent maxillary incisors" EXACT []
synonym: "agenesis of maxillary incisors" EXACT []
synonym: "agenesis of upper incisors" EXACT []
synonym: "aplasia of maxillary incisors" EXACT []
synonym: "aplasia of upper incisors" EXACT []
synonym: "maxillary incisor agenesis" EXACT []
synonym: "maxillary incisor aplasia" EXACT []
synonym: "missing maxillary incisors" EXACT []
synonym: "missing upper incisors" EXACT []
is_a: MP:0030609 ! decreased incisor number

[Term]
id: MP:0004791
name: absent lower incisors
def: "missing the lower pair of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent mandibular incisors" EXACT []
synonym: "agenesis of lower incisors" EXACT []
synonym: "agenesis of mandibular incisors" EXACT []
synonym: "aplasia of lower incisors" EXACT []
synonym: "aplasia of mandibular incisors" EXACT []
synonym: "mandibular incisor agenesis" EXACT []
synonym: "mandibular incisor aplasia" EXACT []
synonym: "missing lower incisors" EXACT []
synonym: "missing mandibular incisors" EXACT []
is_a: MP:0030609 ! decreased incisor number

[Term]
id: MP:0004792
name: abnormal synaptic vesicle number
def: "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004769 ! abnormal synaptic vesicle morphology

[Term]
id: MP:0004793
name: abnormal synaptic vesicle clustering
def: "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004811 ! abnormal neuron physiology

[Term]
id: MP:0004794
name: increased anti-nuclear antigen antibody level
def: "elevated level of antibodies to nuclear antigens present in the sera" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased ANA level" EXACT []
is_a: MP:0003725 ! increased autoantibody level

[Term]
id: MP:0004795
name: decreased anti-nuclear antigen antibody level
def: "reduced level of antibodies to nuclear antigens present in the sera" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced anti-nuclear antigen antibody level" EXACT []
is_a: MP:0003726 ! decreased autoantibody level

[Term]
id: MP:0004796
name: increased anti-histone antibody level
def: "elevated level of antibodies to histones present in the sera" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004794 ! increased anti-nuclear antigen antibody level

[Term]
id: MP:0004797
name: increased anti-erythrocyte antigen antibody level
def: "elevated level of antibodies to erythrocyte antigen present in the sera" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased anti-RBC antibody level" EXACT []
is_a: MP:0003725 ! increased autoantibody level

[Term]
id: MP:0004798
name: decreased anti-double stranded DNA antibody level
def: "reduced level of antibodies to double stranded DNA present in the sera" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced anti-double stranded DNA antibody level" EXACT []
is_a: MP:0004795 ! decreased anti-nuclear antigen antibody level

[Term]
id: MP:0004799
name: increased susceptibility to experimental autoimmune encephalomyelitis
def: "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to EAE" EXACT []
synonym: "decreased resistance to experimental allergic encephalitis" EXACT []
synonym: "decreased resistance to experimental allergic encephalomyelitis" EXACT []
synonym: "decreased resistance to experimental autoimmune encephalomyelitis" EXACT []
synonym: "increased susceptibility to EAE" EXACT []
synonym: "increased susceptibility to experimental allergic encephalitis" EXACT []
synonym: "increased susceptibility to experimental allergic encephalomyelitis" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004800
name: decreased susceptibility to experimental autoimmune encephalomyelitis
def: "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to EAE" EXACT []
synonym: "decreased susceptibility to experimental allergic encephalitis" EXACT []
synonym: "decreased susceptibility to experimental allergic encephalomyelitis" EXACT []
synonym: "increased resistance to EAE" EXACT []
synonym: "increased resistance to experimental allergic encephalitis" EXACT []
synonym: "increased resistance to experimental allergic encephalomyelitis" EXACT []
synonym: "increased resistance to experimental autoimmune encephalomyelitis" EXACT []
synonym: "reduced susceptibility to experimental autoimmune encephalomyelitis" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004801
name: increased susceptibility to systemic lupus erythematosus
def: "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to lupus" EXACT []
synonym: "decreased resistance to SLE" EXACT []
synonym: "decreased resistance to systemic lupus erythematosus" EXACT []
synonym: "increased susceptibility to lupus" EXACT []
synonym: "increased susceptibility to SLE" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004802
name: decreased susceptibility to systemic lupus erythematosus
def: "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to lupus" EXACT []
synonym: "decreased susceptibility to SLE" EXACT []
synonym: "increased resistance to lupus" EXACT []
synonym: "increased resistance to SLE" EXACT []
synonym: "increased resistance to systemic lupus erythematosus" EXACT []
synonym: "reduced susceptibility to systemic lupus erythematosus" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004803
name: increased susceptibility to autoimmune diabetes
def: "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to autoimmune diabetes" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004804
name: decreased susceptibility to autoimmune diabetes
def: "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased resistance to autoimmune diabetes" EXACT []
synonym: "reduced susceptibility to autoimmune diabetes" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004805
name: absent oocytes
def: "absence of mature germ cells in the female" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001117 ! absent gametes
is_a: MP:0005431 ! decreased oocyte number

[Term]
id: MP:0004806
name: absent germ cells
def: "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8]
is_a: MP:0002209 ! decreased germ cell number

[Term]
id: MP:0004807
name: abnormal paired-pulse inhibition
def: "any anomaly in the suppressive response of central synapses when activated twice in rapid succession" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal paired pulse depression" EXACT []
synonym: "abnormal paired pulse inhibition" EXACT []
synonym: "abnormal paired-pulse depression" EXACT []
synonym: "abnormal PPD" EXACT []
synonym: "abnormal PPI" BROAD []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0004808
name: abnormal hematopoietic stem cell morphology
def: "any structural anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal haematopoietic progenitor cell morphology" EXACT []
synonym: "abnormal haematopoietic stem cell morphology" EXACT []
synonym: "abnormal haemopoietic progenitor cell morphology" EXACT []
synonym: "abnormal hematopoietic progenitor cell morphology" EXACT []
synonym: "abnormal hemopoietic progenitor cell morphology" EXACT []
synonym: "abnormal HSCs" RELATED []
synonym: "abnormal LSK cell morphology" NARROW []
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0004809
name: increased hematopoietic stem cell number
def: "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased haematopoietic progenitor cell number" EXACT []
synonym: "increased haematopoietic stem cell number" EXACT []
synonym: "increased haemopoietic progenitor cell number" EXACT []
synonym: "increased hematopoietic progenitor cell number" EXACT []
synonym: "increased hemopoietic progenitor cell number" EXACT []
synonym: "increased HSCs" EXACT []
synonym: "increased LSK cell number" NARROW []
synonym: "increased number of hematopoietic stem cells" EXACT []
is_a: MP:0004808 ! abnormal hematopoietic stem cell morphology
is_a: MP:0011181 ! increased hematopoietic cell number

[Term]
id: MP:0004810
name: decreased hematopoietic stem cell number
def: "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased haematopoietic progenitor cell number" EXACT []
synonym: "decreased haematopoietic stem cell number" EXACT []
synonym: "decreased haemopoietic progenitor cell number" EXACT []
synonym: "decreased hematopoietic progenitor cell number" EXACT []
synonym: "decreased hemopoietic progenitor cell number" EXACT []
synonym: "decreased HSCs" EXACT []
synonym: "decreased LSK cell number" NARROW []
synonym: "decreased number of hematopoietic stem cells" RELATED []
synonym: "reduced haematopoietic stem cell number" EXACT []
synonym: "reduced hematopoietic stem cell number" EXACT []
is_a: MP:0004808 ! abnormal hematopoietic stem cell morphology
is_a: MP:0011182 ! decreased hematopoietic cell number

[Term]
id: MP:0004811
name: abnormal neuron physiology
def: "any functional anomaly of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0004812
name: abnormal linear vestibular evoked potential
def: "anomaly in the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal linear vestibular compound action potentials" EXACT []
synonym: "abnormal VeSPs" EXACT []
is_a: MP:0004742 ! abnormal vestibular system physiology

[Term]
id: MP:0004813
name: absent linear vestibular evoked potential
def: "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004812 ! abnormal linear vestibular evoked potential

[Term]
id: MP:0004814
name: reduced linear vestibular evoked potential
def: "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004812 ! abnormal linear vestibular evoked potential

[Term]
id: MP:0004815
name: abnormal somatic hypermutation frequency
def: "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal SHM" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation
is_a: MP:0002420 ! abnormal adaptive immunity

[Term]
id: MP:0004816
name: abnormal class switch recombination
def: "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CSR" EXACT []
synonym: "abnormal isotype switching" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0004817
name: abnormal skeletal muscle mass
def: "anomaly in the physical bulk, or total amount of matter contained within skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0004818
name: increased skeletal muscle mass
def: "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypermuscularity" EXACT []
is_a: MP:0004817 ! abnormal skeletal muscle mass

[Term]
id: MP:0004819
name: decreased skeletal muscle mass
def: "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced skeletal muscle mass" EXACT []
is_a: MP:0004817 ! abnormal skeletal muscle mass

[Term]
id: MP:0004820
name: abnormal urine potassium level
alt_id: MP:0006311
def: "any change in the amount of potassium in the urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal kidney potassium excretion" EXACT []
synonym: "abnormal renal potassium secretion" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0020887 ! abnormal potassium level

[Term]
id: MP:0004821
name: increased susceptibility to experimental autoimmune uveoretinitis
def: "greater likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to EAU" EXACT []
synonym: "decreased resistance to experimental autoimmune uveitis" EXACT []
synonym: "decreased resistance to experimental autoimmune uveoretinitis" EXACT []
synonym: "increased susceptibility to EAU" EXACT []
synonym: "increased susceptibility to experimental autoimmune uveitis" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004822
name: decreased susceptibility to experimental autoimmune uveoretinitis
def: "reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to EAU" EXACT []
synonym: "decreased susceptibility to experimental autoimmune uveitis" EXACT []
synonym: "increased resistance to EAU" EXACT []
synonym: "increased resistance to experimental autoimmune uveitis" EXACT []
synonym: "increased resistance to experimental autoimmune uveoretinitis" EXACT []
synonym: "reduced susceptibility to experimental autoimmune uveoretinitis" RELATED []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004823
name: increased susceptibility to experimental autoimmune myasthenia gravis
def: "greater likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to EAMG" EXACT []
synonym: "decreased resistance to experimental autoimmune myasthenia gravis" EXACT []
synonym: "increased susceptibility to EAMG" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004824
name: decreased susceptibility to experimental autoimmune myasthenia gravis
def: "reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to EAMG" EXACT []
synonym: "increased resistance to EAMG" EXACT []
synonym: "increased resistance to experimental autoimmune myasthenia gravis" EXACT []
synonym: "reduced susceptibility to experimental autoimmune myasthenia gravis" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004825
name: increased susceptibility to experimental autoimmune thyroiditis
def: "greater likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to EAT" EXACT []
synonym: "decreased resistance to experimental autoimmune thyroiditis" EXACT []
synonym: "increased susceptibility to EAT" EXACT []
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004826
name: decreased susceptibility to experimental autoimmune thyroiditis
def: "reduced likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to EAT" EXACT []
synonym: "increased resistance to EAT" EXACT []
synonym: "increased resistance to experimental autoimmune thyroiditis" EXACT []
synonym: "reduced susceptibility to experimental autoimmune thyroiditis" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004827
name: increased susceptibility to autoimmune hemolytic anemia
def: "greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to autoimmune hemolytic anaemia" EXACT []
synonym: "decreased resistance to autoimmune hemolytic anemia" EXACT []
synonym: "decreased resistance to idiopathic autoimmune hemolytic anaemia (AIHA)" EXACT []
synonym: "decreased resistance to idiopathic autoimmune hemolytic anemia (AIHA)" EXACT []
synonym: "decreased resistance to immune mediated hemolytic anaemia (IMHA)" EXACT []
synonym: "decreased resistance to immune mediated hemolytic anemia (IMHA)" EXACT []
synonym: "increased susceptibility to autoimmune haemolytic anaemia" EXACT []
synonym: "increased susceptibility to autoimmune hemolytic anaemia" EXACT []
synonym: "increased susceptibility to idiopathic autoimmune hemolytic anaemia (AIHA)" EXACT []
synonym: "increased susceptibility to idiopathic autoimmune hemolytic anemia (AIHA)" EXACT []
synonym: "increased susceptibility to immune mediated hemolytic anaemia (IMHA)" EXACT []
synonym: "increased susceptibility to immune mediated hemolytic anemia (IMHA)" EXACT []
is_a: MP:0001585 ! hemolytic anemia
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder

[Term]
id: MP:0004828
name: decreased susceptibility to autoimmune hemolytic anemia
def: "reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to autoimmune haemolytic anaemia" EXACT []
synonym: "decreased susceptibility to autoimmune hemolytic anaemia" EXACT []
synonym: "decreased susceptibility to idiopathic autoimmune hemolytic anaemia (AIHA)" EXACT []
synonym: "decreased susceptibility to idiopathic autoimmune hemolytic anemia (AIHA)" EXACT []
synonym: "decreased susceptibility to immune mediated hemolytic anaemia (IMHA)" EXACT []
synonym: "decreased susceptibility to immune mediated hemolytic anemia (IMHA)" EXACT []
synonym: "increased resistance to autoimmune hemolytic anaemia" EXACT []
synonym: "increased resistance to autoimmune hemolytic anemia" EXACT []
synonym: "increased resistance to idiopathic autoimmune hemolytic anaemia (AIHA)" EXACT []
synonym: "increased resistance to idiopathic autoimmune hemolytic anemia (AIHA)" EXACT []
synonym: "increased resistance to immune mediated hemolytic anaemia (IMHA)" EXACT []
synonym: "increased resistance to immune mediated hemolytic anemia (IMHA)" EXACT []
synonym: "reduced susceptibility to autoimmune hemolytic anaemia" EXACT []
synonym: "reduced susceptibility to autoimmune hemolytic anemia" EXACT []
is_a: MP:0001585 ! hemolytic anemia
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder

[Term]
id: MP:0004829
name: increased anti-chromatin antibody level
def: "increase in the level of antibodies that recognize chromatin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004794 ! increased anti-nuclear antigen antibody level

[Term]
id: MP:0004830
name: short incisors
def: "reduced length of the set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased incisor length" EXACT []
is_a: MP:0030079 ! small incisors

[Term]
id: MP:0004831
name: long incisors
def: "increased length of the set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "increased incisor length" EXACT []
synonym: "overgrown incisors" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0030091 ! macrodontia

[Term]
id: MP:0004832
name: enlarged ovary
def: "increased size of the female reproductive gland containing the germ cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased ovary size" EXACT []
is_a: MP:0004853 ! abnormal ovary size
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0004833
name: ovary atrophy
def: "acquired diminution of the size of the ovaries associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "ovarian atrophy" EXACT []
is_a: MP:0001127 ! small ovary

[Term]
id: MP:0004834
name: ovary hemorrhage
def: "presence of bleeding in the ovary" [https://orcid.org/0000-0003-3691-0324]
synonym: "ovarian haemorrhage" EXACT []
synonym: "ovarian hemorrhage" EXACT []
synonym: "ovary haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0003507 ! abnormal ovary physiology
is_a: MP:0004245 ! genital hemorrhage

[Term]
id: MP:0004835
name: abnormal miniature endplate potential
def: "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mEPP" EXACT []
synonym: "abnormal miniature end plate potential" EXACT []
is_a: MP:0002913 ! abnormal PNS synaptic transmission

[Term]
id: MP:0004836
name: abnormal synaptic acetylcholine release
def: "aberrant release into synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal AcH release" EXACT []
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0004837
name: abnormal neural fold formation
def: "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neural groove formation" EXACT []
is_a: MP:0011256 ! abnormal neural fold morphology

[Term]
id: MP:0004838
name: abnormal neural fold elevation formation
def: "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004837 ! abnormal neural fold formation

[Term]
id: MP:0004839
name: bile duct hyperplasia
def: "increase in the number of normal cells in normal arrangement in the bile ducts, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic bile ducts" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0004840
name: increased Deiters cell number
def: "increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [https://orcid.org/0000-0002-6490-7723]
synonym: "extra Deiters cells" EXACT []
synonym: "extra row(s) of Deiters cells" EXACT []
synonym: "supernumerary Deiters cells" EXACT []
is_a: MP:0004302 ! abnormal Deiters cell morphology

[Term]
id: MP:0004841
name: abnormal small intestine crypts of Lieberkuhn morphology
def: "any structural anomaly of the parallel, tubular, epithelial pits (crypts) with openings at the bases of the small intestinal villi; their thin walls are formed by columnar epithelial cells: mostly undifferentiated stem and intermediate cells and an increasing number of mucus-secreting goblet cells as the small intestine proceeds distally, all of which migrate out of the glands onto the villi, but also protein- (enzyme-) secreting Paneth cells that remain in the glands" [http://medical-dictionary.thefreedictionary.com/glands+of+small+intestine, https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal glandulae intestini tenuis morphology" EXACT []
synonym: "abnormal small intestine crypt morphology" EXACT []
synonym: "abnormal small intestine gland morphology" EXACT []
is_a: MP:0000490 ! abnormal crypts of Lieberkuhn morphology
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0004842
name: abnormal large intestine crypts of Lieberkuhn morphology
def: "any structural anomaly of the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8]
is_a: MP:0000489 ! abnormal large intestine morphology
is_a: MP:0000490 ! abnormal crypts of Lieberkuhn morphology

[Term]
id: MP:0004843
name: abnormal Paneth cell morphology
def: "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal Davidoff cell morphology" EXACT []
synonym: "abnormal Paneth granule cell morphology" EXACT []
is_a: MP:0004841 ! abnormal small intestine crypts of Lieberkuhn morphology

[Term]
id: MP:0004844
name: abnormal vestibuloocular reflex
alt_id: MP:0001477
alt_id: MP:0001992
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system in which impulses are conveyed from the semicircular canals and the otolithic membrane to the oculomotor nerve; this stimulation may occur by angular acceleration or deceleration or by irrigation of the ear with hot or cold water; normally, this reflex functions to maintain a stable retinal image during head rotation by generating appropriate compensatory eye movements" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal eye reflex" EXACT []
synonym: "abnormal nystagmus" EXACT []
synonym: "abnormal ocular reflex" EXACT []
synonym: "abnormal vestibulo ocular reflex" EXACT []
synonym: "abnormal VOR" EXACT []
is_a: MP:0001961 ! abnormal reflex
is_a: MP:0004742 ! abnormal vestibular system physiology

[Term]
id: MP:0004845
name: absent vestibuloocular reflex
def: "absence of nystagmus or deviation of the eyes in response to stimulation of the vestibular system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004844 ! abnormal vestibuloocular reflex

[Term]
id: MP:0004846
name: absent skeletal muscle
def: "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0004847
name: abnormal liver weight
def: "anomaly in the average weight of the bile-secreting exocrine gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic weight" EXACT []
is_a: MP:0004848 ! abnormal liver size

[Term]
id: MP:0004848
name: abnormal liver size
def: "anomaly in the average size of the liver" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "abnormal hepatic size" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0004849
name: abnormal testis size
def: "anomaly in the size of the male reproductive glands" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal testes size" EXACT []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0004850
name: abnormal testis weight
def: "anomaly in the average weight of the male reproductive glands" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal testes weight" EXACT []
is_a: MP:0004849 ! abnormal testis size

[Term]
id: MP:0004851
name: increased testis weight
def: "greater average weight of the male reproductive glands" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001148 ! enlarged testis
is_a: MP:0004850 ! abnormal testis weight

[Term]
id: MP:0004852
name: decreased testis weight
def: "reduced average weight of the male reproductive glands" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced testis weight" EXACT []
is_a: MP:0001147 ! small testis
is_a: MP:0004850 ! abnormal testis weight

[Term]
id: MP:0004853
name: abnormal ovary size
def: "anomaly in the average size of the female reproductive gland containing the germ cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0004854
name: abnormal ovary weight
def: "anomaly in the average weight of the female reproductive gland containing the germ cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004853 ! abnormal ovary size

[Term]
id: MP:0004855
name: increased ovary weight
def: "greater average weight of the female reproductive gland containing the germ cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004832 ! enlarged ovary
is_a: MP:0004854 ! abnormal ovary weight

[Term]
id: MP:0004856
name: decreased ovary weight
def: "reduction in the average weight of the female reproductive gland containing the germ cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced ovary weight" EXACT []
is_a: MP:0001127 ! small ovary
is_a: MP:0004854 ! abnormal ovary weight

[Term]
id: MP:0004857
name: abnormal heart weight
def: "anomaly in the average weight of the heart compared to controls" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005406 ! abnormal heart size

[Term]
id: MP:0004858
name: abnormal nervous system regeneration
def: "anomaly in the renewal, repair, and/or regrowth of nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0004859
name: abnormal synaptic plasticity
def: "anomaly in the ability of a synapse to change its strength as a result of successive activations" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
is_a: MP:0021009 ! abnormal synaptic physiology

[Term]
id: MP:0004860
name: dilated kidney collecting duct
def: "stretched or widened aperture of the luminal space of one or more of the kidney collecting ducts" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated kidney collecting ducts" EXACT []
synonym: "dilated kidney collecting tube" EXACT []
synonym: "dilated kidney collecting tubes" EXACT []
synonym: "dilated kidney collecting tubule" EXACT []
synonym: "dilated kidney collecting tubules" EXACT []
synonym: "dilated renal collecting duct" EXACT []
synonym: "dilated renal collecting ducts" EXACT []
synonym: "dilated renal collecting tube" EXACT []
synonym: "dilated renal collecting tubes" EXACT []
synonym: "dilated renal collecting tubule" EXACT []
synonym: "dilated renal collecting tubules" EXACT []
synonym: "kidney collecting duct dilation" RELATED []
synonym: "kidney collecting tubule dilation" EXACT []
synonym: "renal collecting duct dilation" EXACT []
synonym: "renal collecting tubule dilation" EXACT []
is_a: MP:0004754 ! abnormal kidney collecting duct morphology

[Term]
id: MP:0004861
name: abnormal Raphe nucleus morphology
def: "any structural anomaly of the subgroup of the reticular nuclei of the brain stem that are located in and along the median plane of the medulla oblongata, pons, and mesencephalon that include neurons that synthesize serotonin and extend ascending fibers to parts of the limbic system and descending fibers to other brain stem nuclei, the medulla oblongata, and the pons" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal median column reticular nuclei" EXACT []
synonym: "abnormal Raphe nuclei" EXACT []
is_a: MP:0005277 ! abnormal brainstem morphology

[Term]
id: MP:0004862
name: small scala tympani
def: "volume reduction of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced scala tympani" EXACT []
is_a: MP:0003167 ! abnormal scala tympani morphology

[Term]
id: MP:0004863
name: thin spiral ligament
def: "reduced thickness of the periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004288 ! abnormal spiral ligament morphology

[Term]
id: MP:0004864
name: spiral ligament degeneration
def: "degeneration or loss of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000032 ! cochlear degeneration
is_a: MP:0004288 ! abnormal spiral ligament morphology

[Term]
id: MP:0004865
name: abnormal platelet calcium level
def: "anomaly in the amount in the platelet of calcium" [RGD:cur]
is_a: MP:0004721 ! abnormal platelet dense granule morphology
is_a: MP:0020879 ! abnormal calcium level

[Term]
id: MP:0004866
name: increased platelet calcium level
def: "increased concentration in the platelet of calcium" [RGD:cur]
is_a: MP:0004865 ! abnormal platelet calcium level
is_a: MP:0014537 ! increased calcium level

[Term]
id: MP:0004867
name: decreased platelet calcium level
def: "decreased concentration in the platelet of calcium" [RGD:cur]
synonym: "reduced platelet calcium level" EXACT []
is_a: MP:0004865 ! abnormal platelet calcium level
is_a: MP:0014538 ! decreased calcium level

[Term]
id: MP:0004868
name: increased endometrial carcinoma incidence
def: "greater than the expected number of a malignant neoplasm arising from the endometrial tissue, occurring in a specific population in a given time period" [RGD:cur]
synonym: "endometrial carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0009222 ! increased uterus tumor incidence

[Term]
id: MP:0004869
name: frontal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the frontal bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic frontal bone" EXACT []
is_a: MP:0004377 ! small frontal bone
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004870
name: small premaxilla
def: "reduced size of the anterior and interior portion of the maxilla" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002820 ! abnormal premaxilla morphology

[Term]
id: MP:0004871
name: premaxilla hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the premaxilla, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic premaxilla" EXACT []
is_a: MP:0004870 ! small premaxilla
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0004872
name: absent nasal septum
def: "absence of the structure that separates the two nasal cavities" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002239 ! abnormal nasal septum morphology

[Term]
id: MP:0004873
name: absent turbinates
def: "absence of the small curved bones that extend horizontally along the lateral wall of the nasal passage" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent nasal conchae" EXACT []
is_a: MP:0002244 ! abnormal turbinate morphology
is_a: MP:0030385 ! absent facial bone

[Term]
id: MP:0004874
name: abnormal timing of postnatal eyelid opening
def: "anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open" [https://orcid.org/0000-0003-3691-0324]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later (P8-12).
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal timing of eye lid opening" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0004875
name: increased mean systemic arterial blood pressure
def: "increase in the average arterial pressure during a single cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased MAP" RELATED []
synonym: "increased mean arterial pressure" EXACT []
is_a: MP:0002842 ! increased systemic arterial blood pressure

[Term]
id: MP:0004876
name: decreased mean systemic arterial blood pressure
def: "decrease in the average arterial pressure during a single cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased MAP" EXACT []
synonym: "decreased mean arterial pressure" EXACT []
synonym: "reduced MAP" EXACT []
synonym: "reduced mean arterial blood pressure" EXACT []
synonym: "reduced mean arterial pressure" EXACT []
is_a: MP:0002843 ! decreased systemic arterial blood pressure

[Term]
id: MP:0004877
name: abnormal systemic vascular resistance
def: "anomaly in the normal force opposing blood flow in the peripheral blood vessels" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal SVR" EXACT []
synonym: "abnormal total peripheral resistance" EXACT []
is_a: MP:0005532 ! abnormal vascular resistance

[Term]
id: MP:0004878
name: increased systemic vascular resistance
def: "increase in the normal force opposing blood flow in the peripheral blood vessels" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased SVR" EXACT []
is_a: MP:0004877 ! abnormal systemic vascular resistance

[Term]
id: MP:0004879
name: decreased systemic vascular resistance
def: "reduction in the normal force opposing blood flow in the peripheral blood vessels" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased SVR" EXACT []
synonym: "reduced systemic vascular resistance" EXACT []
is_a: MP:0004877 ! abnormal systemic vascular resistance

[Term]
id: MP:0004880
name: lung cyst
def: "presence of one or more abnormal membranous or fluid-filled sacs in the lung" [https://orcid.org/0000-0003-3691-0324]
synonym: "cystic lung" EXACT []
synonym: "cystic lungs" EXACT []
synonym: "lung cysts" EXACT []
synonym: "pulmonary cyst" EXACT []
synonym: "pulmonary cysts" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0004881
name: abnormal lung size
def: "anomaly in the size of the lung compared to controls" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0004882
name: enlarged lung
def: "increased size of the lung compared to controls" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lung size" EXACT []
is_a: MP:0004881 ! abnormal lung size
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0004883
name: abnormal vascular wound healing
def: "anomaly in the repair process of damaged blood vessels after injury" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal blood vessel healing" EXACT []
synonym: "abnormal neointima formation" NARROW []
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0005023 ! abnormal wound healing

[Term]
id: MP:0004884
name: abnormal testis physiology
def: "any functional anomaly of the male reproductive glands" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal didymus physiology" EXACT []
synonym: "abnormal male gonad physiology" EXACT []
synonym: "abnormal testicle physiology" EXACT []
synonym: "abnormal testicular physiology" EXACT []
synonym: "abnormal testiculus physiology" EXACT []
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0013327 ! abnormal male reproductive gland physiology

[Term]
id: MP:0004885
name: abnormal endolymph physiology
def: "any alteration in the normal production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear; unlike perilymph, endolymph resembles intracellular fluid in composition and has a high concentration of potassium ion and a low concentration of sodium ion" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal endolympha" EXACT []
synonym: "abnormal Scarpa's fluid" EXACT []
synonym: "abnormal Scarpa's liquor" EXACT []
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0004886
name: increased endolymph production
def: "increased synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased endolympha production" EXACT []
synonym: "increased Scarpa fluid production" EXACT []
synonym: "increased Scarpa liquor production" EXACT []
is_a: MP:0004885 ! abnormal endolymph physiology

[Term]
id: MP:0004887
name: decreased endolymph production
def: "reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased endolympha production" EXACT []
synonym: "decreased Scarpa fluid production" EXACT []
synonym: "decreased Scarpa liquor production" EXACT []
synonym: "reduced endolymph production" RELATED []
is_a: MP:0004885 ! abnormal endolymph physiology

[Term]
id: MP:0004888
name: abnormal perilymph physiology
def: "change in the normal production (volume) or ionic homeostasis of the fluid contained within the osseous labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition, has a high concentration of sodium ion and a low concentration of potassium ion and, through the perilymphatic duct, is in continuity with cerebrospinal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Cotunnius liquid" EXACT []
synonym: "abnormal perilympha" EXACT []
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0004889
name: increased energy expenditure
def: "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
synonym: "increased energy efficiency" EXACT []
is_a: MP:0005450 ! abnormal energy expenditure

[Term]
id: MP:0004890
name: decreased energy expenditure
def: "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased energy efficiency" EXACT []
synonym: "reduced energy expenditure" EXACT []
is_a: MP:0005450 ! abnormal energy expenditure

[Term]
id: MP:0004891
name: abnormal adiponectin level
def: "abnormal level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0004892
name: increased adiponectin level
def: "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004891 ! abnormal adiponectin level
is_a: MP:0014454 ! increased hormone level

[Term]
id: MP:0004893
name: decreased adiponectin level
def: "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced adiponectin level" EXACT []
is_a: MP:0004891 ! abnormal adiponectin level
is_a: MP:0014455 ! decreased hormone level

[Term]
id: MP:0004894
name: uterus atrophy
def: "acquired diminution of the size of the uterus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "metra atrophy" EXACT []
synonym: "metral atrophy" EXACT []
synonym: "uterine atrophy" EXACT []
is_a: MP:0002637 ! small uterus

[Term]
id: MP:0004895
name: vagina atrophy
def: "acquired diminution of the size of the vagina associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "vaginal atrophy" RELATED []
is_a: MP:0008983 ! small vagina

[Term]
id: MP:0004896
name: abnormal endometrium morphology
def: "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [https://orcid.org/0000-0003-4606-0597, MESH:A05.360.319.679.490]
synonym: "endometrium dysplasia" NARROW []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0004897
name: otosclerosis
def: "formation of spongy bone in the bony labyrinth of the ear, especially adjacent to the footplate of the stapes; it may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis results in sensorineural hearing loss" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004289 ! abnormal bony labyrinth

[Term]
id: MP:0004898
name: uterine hemorrhage
def: "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2]
synonym: "uterine haemorrhage" EXACT []
synonym: "uterus bleeding" EXACT []
synonym: "uterus haemorrhage" EXACT []
synonym: "uterus hemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0004245 ! genital hemorrhage
is_a: MP:0009671 ! abnormal uterus physiology

[Term]
id: MP:0004899
name: absent temporal bone squamous part
def: "absence of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent squama temporalis" EXACT []
synonym: "absent squamosal bone" EXACT []
synonym: "absent squamous bone" EXACT []
synonym: "absent squamous part of temporal bone" EXACT []
synonym: "absent squamous temporal bone" EXACT []
synonym: "absent temporal squama" EXACT []
is_a: MP:0004423 ! abnormal temporal bone squamous part morphology

[Term]
id: MP:0004900
name: absent zygomatic arch
def: "absence of the bony arch that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004469 ! abnormal zygomatic arch morphology

[Term]
id: MP:0004901
name: decreased male germ cell number
def: "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [https://orcid.org/0000-0003-4606-0597, MGI:llw2]
synonym: "decreased number of male germ cells" EXACT []
synonym: "male germ cell hypoplasia" RELATED []
synonym: "reduced male germ cell number" EXACT []
is_a: MP:0002209 ! decreased germ cell number
is_a: MP:0006362 ! abnormal male germ cell morphology

[Term]
id: MP:0004902
name: abnormal uterus size
def: "anomaly in the size of the female organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal metra size" EXACT []
synonym: "abnormal metral size" EXACT []
synonym: "abnormal uterine size" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0004903
name: abnormal uterus weight
def: "anomaly in the weight of the female organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal metra weight" RELATED []
synonym: "abnormal metral weight" EXACT []
synonym: "abnormal uterine weight" EXACT []
is_a: MP:0004902 ! abnormal uterus size

[Term]
id: MP:0004904
name: increased uterus weight
def: "increase in the weight of the female organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased metra weight" EXACT []
synonym: "increased metral weight" EXACT []
synonym: "increased uterine weight" EXACT []
is_a: MP:0004903 ! abnormal uterus weight
is_a: MP:0004906 ! enlarged uterus

[Term]
id: MP:0004905
name: decreased uterus weight
def: "reduction in the weight of the female organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased metra weight" EXACT []
synonym: "decreased metral weight" EXACT []
synonym: "decreased uterine weight" EXACT []
synonym: "reduced uterine weight" EXACT []
synonym: "reduced uterus weight" EXACT []
is_a: MP:0002637 ! small uterus
is_a: MP:0004903 ! abnormal uterus weight

[Term]
id: MP:0004906
name: enlarged uterus
def: "increased size of the female muscular organ of gestation" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged metra" EXACT []
synonym: "increased uterine size" EXACT []
synonym: "increased uterus size" EXACT []
is_a: MP:0004902 ! abnormal uterus size

[Term]
id: MP:0004907
name: abnormal seminal vesicle size
def: "anomaly in the size of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal seminal gland size" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0004908
name: abnormal seminal vesicle weight
def: "anomaly in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal seminal gland weight" EXACT []
is_a: MP:0004907 ! abnormal seminal vesicle size

[Term]
id: MP:0004909
name: increased seminal vesicle weight
def: "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased seminal gland weight" EXACT []
is_a: MP:0002997 ! enlarged seminal vesicle
is_a: MP:0004908 ! abnormal seminal vesicle weight

[Term]
id: MP:0004910
name: decreased seminal vesicle weight
def: "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased seminal gland weight" EXACT []
synonym: "reduced seminal gland weight" EXACT []
synonym: "reduced seminal vesicle weight" EXACT []
is_a: MP:0001157 ! small seminal vesicle
is_a: MP:0004908 ! abnormal seminal vesicle weight

[Term]
id: MP:0004911
name: absent mandibular condyloid process
def: "absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004595 ! abnormal mandibular condyloid process morphology

[Term]
id: MP:0004912
name: absent mandibular coronoid process
def: "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004594 ! abnormal mandibular coronoid process morphology

[Term]
id: MP:0004913
name: absent mandibular angle
def: "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent gonial angle" EXACT []
synonym: "absent mandible angular process" EXACT []
synonym: "missing angular process of the mandible" EXACT []
is_a: MP:0004596 ! abnormal mandibular angle morphology

[Term]
id: MP:0004914
name: absent ultimobranchial body
def: "absence of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth" [PMID:20144910]
synonym: "absent corpus ultimopharyngeum" EXACT []
synonym: "absent postbranchial body" EXACT []
synonym: "absent telobranchial body" EXACT []
synonym: "absent telopharyngeal body" EXACT []
synonym: "absent ultimobranchial gland" EXACT []
synonym: "absent ultimopharyngeal body" EXACT []
synonym: "absent ultimopharyngeal gland" EXACT []
is_a: MP:0003955 ! abnormal ultimobranchial body morphology

[Term]
id: MP:0004915
name: abnormal Reichert's cartilage morphology
def: "any structural anomaly of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hyoid cartilage morphology" EXACT []
synonym: "abnormal Reichert cartilage morphology" EXACT []
synonym: "abnormal Reicherts cartilage morphology" EXACT []
synonym: "abnormal second pharyngeal arch cartilage morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0004916
name: absent Reichert cartilage
def: "absence of the cartilage normally found in the mesenchyme of the second branchial arch in the embryo, from which develop the stapes, the styloid processes, the stylohyoid ligaments, and the lesser cornua of the hyoid bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent hyoid cartilage" RELATED []
synonym: "absent Reicherts cartilage" EXACT []
synonym: "absent second pharyngeal arch cartilage" RELATED []
is_a: MP:0004915 ! abnormal Reichert's cartilage morphology

[Term]
id: MP:0004917
name: abnormal T cell selection
def: "any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation" [GO:0045058]
is_a: MP:0002145 ! abnormal T cell differentiation

[Term]
id: MP:0004918
name: abnormal negative T cell selection
def: "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
is_a: MP:0004917 ! abnormal T cell selection

[Term]
id: MP:0004919
name: abnormal positive T cell selection
def: "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
is_a: MP:0004917 ! abnormal T cell selection

[Term]
id: MP:0004920
name: increased placenta weight
def: "increase in the weight of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004257 ! abnormal placenta weight
is_a: MP:0004260 ! enlarged placenta

[Term]
id: MP:0004921
name: decreased placenta weight
def: "reduction in the weight of the organ of metabolic interchange between fetus and mother" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced placenta weight" EXACT []
is_a: MP:0004257 ! abnormal placenta weight
is_a: MP:0004259 ! small placenta

[Term]
id: MP:0004922
name: abnormal common crus morphology
def: "any structural anomaly in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal common crus of semicircular ducts" EXACT []
synonym: "abnormal common membranous limb of membranous semicircular ducts" EXACT []
synonym: "abnormal crus membranaceum commune ductuum semicircularium" EXACT []
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0004923
name: absent common crus
def: "absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent common crus of semicircular ducts" EXACT []
synonym: "absent common membranous limb of membranous semicircular ducts" EXACT []
synonym: "absent crus membranaceum commune ductuum semicircularium" EXACT []
is_a: MP:0004922 ! abnormal common crus morphology

[Term]
id: MP:0004924
name: abnormal behavior
def: "any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal behaviour" EXACT []
synonym: "abnormal general behavior" RELATED []
synonym: "abnormal general behaviour" RELATED []
is_a: MP:0005386 ! behavior/neurological phenotype

[Term]
id: MP:0004925
name: decreased susceptibility to noise-induced hearing loss
def: "less than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to noise-induced hearing loss" EXACT []
synonym: "reduced susceptibility to noise-induced hearing loss" EXACT []
is_a: MP:0006334 ! abnormal susceptibility to hearing loss

[Term]
id: MP:0004926
name: abnormal epididymis size
def: "anomaly in the size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0004927
name: abnormal epididymis weight
def: "anomaly in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004926 ! abnormal epididymis size

[Term]
id: MP:0004928
name: increased epididymis weight
def: "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004927 ! abnormal epididymis weight
is_a: MP:0004931 ! enlarged epididymis

[Term]
id: MP:0004929
name: decreased epididymis weight
def: "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced epididymis weight" EXACT []
is_a: MP:0004927 ! abnormal epididymis weight
is_a: MP:0004930 ! small epididymis

[Term]
id: MP:0004930
name: small epididymis
def: "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased epididymis size" EXACT []
is_a: MP:0004926 ! abnormal epididymis size

[Term]
id: MP:0004931
name: enlarged epididymis
def: "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased epididymis size" EXACT []
is_a: MP:0004926 ! abnormal epididymis size

[Term]
id: MP:0004932
name: epididymis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the epididymis, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic epididymis" EXACT []
is_a: MP:0004930 ! small epididymis

[Term]
id: MP:0004933
name: abnormal epididymis epithelium morphology
def: "any structural anomaly of the layer of secretory cells which lines the epididymis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0004934
name: epididymis epithelium degeneration
def: "pathological deterioration of the layer of secretory cells which lines the epididymis" [https://orcid.org/0000-0003-3691-0324]
synonym: "epididymis epithelial degeneration" EXACT []
is_a: MP:0004933 ! abnormal epididymis epithelium morphology
is_a: MP:0004935 ! epididymis degeneration

[Term]
id: MP:0004935
name: epididymis degeneration
def: "pathological deterioration of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0003-3691-0324]
synonym: "epididymal degeneration" EXACT []
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0004936
name: impaired branching involved in ureteric bud morphogenesis
def: "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired ureteric bud branching morphogenesis" EXACT []
is_a: MP:0010981 ! abnormal branching involved in ureteric bud morphogenesis

[Term]
id: MP:0004937
name: dilated heart
def: "stretched or widened aperture of one or more of the luminal spaces of the heart, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiac dilation" EXACT []
synonym: "dilated hearts" EXACT []
synonym: "heart dilation" EXACT []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0004938
name: dilated vasculature
def: "stretched or widened aperture of the luminal space of one or more of the blood vessels" [https://orcid.org/0000-0003-3691-0324]
synonym: "blood vessel dilation" EXACT []
synonym: "dilated blood vessel" EXACT []
synonym: "dilated blood vessels" EXACT []
synonym: "vasculature dilation" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0004939
name: abnormal B cell morphology
def: "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal B lymphocyte morphology" EXACT []
synonym: "abnormal B-cell morphology" EXACT []
is_a: MP:0002619 ! abnormal lymphocyte morphology

[Term]
id: MP:0004940
name: abnormal B-1 B cell morphology
def: "any structural anomaly of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "abnormal B-1 B lymphocyte morphology" EXACT []
synonym: "abnormal B-1 B-cell morphology" EXACT []
synonym: "abnormal B-1 B-lymphocyte morphology" EXACT []
synonym: "abnormal B1 cell morphology" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0004941
name: abnormal regulatory T cell morphology
alt_id: MP:0002437
def: "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal regulatory T lymphocyte morphology" EXACT []
synonym: "abnormal regulatory T-cell morphology" EXACT []
synonym: "abnormal regulatory T-lymphocyte" EXACT []
synonym: "abnormal suppressor T cell morphology" EXACT []
synonym: "abnormal suppressor T cell morphology/development" EXACT []
synonym: "abnormal suppressor T lymphocyte morphology" EXACT []
synonym: "abnormal suppressor T-cell morphology" EXACT []
synonym: "abnormal suppressor T-lymphocyte morphology" EXACT []
synonym: "abnormal Treg cell morphology" NARROW []
synonym: "suppressor T cell abnormalities" EXACT []
synonym: "suppressor T-cell abnormalities" EXACT []
xref: CL:0000815
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0004942
name: abnormal B cell selection
def: "anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival" [GO:0002339]
xref: GO:0002339
is_a: MP:0002144 ! abnormal B cell differentiation

[Term]
id: MP:0004943
name: abnormal B cell positive selection
def: "any anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival" [https://orcid.org/0000-0003-3691-0324]
xref: GO:0002346
is_a: MP:0004942 ! abnormal B cell selection

[Term]
id: MP:0004944
name: abnormal B cell negative selection
def: "any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [https://orcid.org/0000-0003-3691-0324]
xref: GO:0002352
is_a: MP:0004942 ! abnormal B cell selection

[Term]
id: MP:0004945
name: abnormal bone resorption
def: "anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002998 ! abnormal bone remodeling

[Term]
id: MP:0004946
name: abnormal regulatory T cell physiology
def: "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0004947
name: skin inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "rubor" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0004948
name: abnormal neuronal precursor proliferation
def: "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neuroblast proliferation" EXACT []
synonym: "abnormal neuronal progenitor proliferation" EXACT []
is_a: MP:0009967 ! abnormal neuron proliferation

[Term]
id: MP:0004949
name: absent neuronal precursor cells
def: "absence of the neuroblast embryonic cells that develop into nerve cells or neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent neuroblast cells" EXACT []
synonym: "absent neuronal progenitor cells" EXACT []
synonym: "absent NPCs" EXACT []
is_a: MP:0004981 ! decreased neuronal precursor cell number

[Term]
id: MP:0004950
name: abnormal brain vasculature morphology
def: "any structural anomaly of the blood vessel network of the brain" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0014012 ! abnormal cranial blood vasculature morphology

[Term]
id: MP:0004951
name: abnormal spleen weight
def: "anomaly in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal splenic weight" EXACT []
is_a: MP:0002224 ! abnormal spleen size

[Term]
id: MP:0004952
name: increased spleen weight
def: "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased splenic weight" EXACT []
is_a: MP:0000691 ! enlarged spleen
is_a: MP:0004951 ! abnormal spleen weight

[Term]
id: MP:0004953
name: decreased spleen weight
def: "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased splenic weight" RELATED []
synonym: "reduced spleen weight" EXACT []
is_a: MP:0000692 ! small spleen
is_a: MP:0004951 ! abnormal spleen weight

[Term]
id: MP:0004954
name: abnormal thymus weight
def: "anomaly in the average weight of the primary lymphoid organ that is required for maturation of T cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002364 ! abnormal thymus size

[Term]
id: MP:0004955
name: increased thymus weight
def: "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000709 ! enlarged thymus
is_a: MP:0004954 ! abnormal thymus weight

[Term]
id: MP:0004956
name: decreased thymus weight
def: "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced thymus weight" EXACT []
is_a: MP:0000706 ! small thymus
is_a: MP:0004954 ! abnormal thymus weight

[Term]
id: MP:0004957
name: abnormal blastocyst morphology
def: "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014137 ! abnormal preimplantation embryo morphology

[Term]
id: MP:0004958
name: enlarged prostate gland
def: "increased size of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased prostate gland size" EXACT []
is_a: MP:0004959 ! abnormal prostate gland size

[Term]
id: MP:0004959
name: abnormal prostate gland size
def: "anomaly in the average size of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal prostate size" EXACT []
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0004960
name: abnormal prostate gland weight
def: "anomaly in the average weight of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal prostate weight" RELATED []
is_a: MP:0004959 ! abnormal prostate gland size

[Term]
id: MP:0004961
name: increased prostate gland weight
def: "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased prostate weight" EXACT []
is_a: MP:0004958 ! enlarged prostate gland
is_a: MP:0004960 ! abnormal prostate gland weight

[Term]
id: MP:0004962
name: decreased prostate gland weight
def: "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased prostate weight" RELATED []
synonym: "reduced prostate weight" EXACT []
is_a: MP:0002774 ! small prostate gland
is_a: MP:0004960 ! abnormal prostate gland weight

[Term]
id: MP:0004963
name: abnormal blastocoele morphology
def: "any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal blastocoel cavity" EXACT []
is_a: MP:0004957 ! abnormal blastocyst morphology

[Term]
id: MP:0004964
name: absent inner cell mass
def: "absence of the cells of the blastocyst that develop into the body of the embryo" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002718 ! abnormal inner cell mass morphology

[Term]
id: MP:0004965
name: inner cell mass degeneration
def: "a retrogressive impairment of function or destruction of the cells of the blastocyst that develop into the body of the embryo" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002718 ! abnormal inner cell mass morphology

[Term]
id: MP:0004966
name: abnormal inner cell mass proliferation
def: "any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal inner cell mass growth" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0008932 ! abnormal embryonic tissue physiology

[Term]
id: MP:0004967
name: abnormal kidney epithelium morphology
def: "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal renal epithelium morphology" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0004968
name: kidney epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the kidney epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic renal epithelium" EXACT []
synonym: "renal epithelial hyperplasia" EXACT []
synonym: "renal epithelium hyperplasia" EXACT []
is_a: MP:0004967 ! abnormal kidney epithelium morphology

[Term]
id: MP:0004969
name: pale kidney
def: "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0004970
name: kidney atrophy
alt_id: MP:0003013
def: "acquired diminution of the size of the kidney associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "renal atrophy" EXACT []
is_a: MP:0002989 ! small kidney

[Term]
id: MP:0004971
name: dermal hyperplasia
def: "increase in the number of normal cells in normal arrangement in the dermal layer of the skin, typically resulting in increased thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "excessive skin" BROAD []
synonym: "hyperplastic dermal layer" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0004972
name: abnormal regulatory T cell number
def: "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal suppressor T cell number" EXACT []
synonym: "abnormal Treg cell number" EXACT []
is_a: MP:0004941 ! abnormal regulatory T cell morphology
is_a: MP:0006387 ! abnormal T cell number

[Term]
id: MP:0004973
name: increased regulatory T cell number
def: "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased suppressor T cell number" EXACT []
synonym: "increased Treg cell number" EXACT []
is_a: MP:0004972 ! abnormal regulatory T cell number
is_a: MP:0005015 ! increased T cell number

[Term]
id: MP:0004974
name: decreased regulatory T cell number
def: "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased suppressor T cell number" EXACT []
synonym: "decreased Treg cell number" EXACT []
synonym: "reduced regulatory T cell number" EXACT []
synonym: "reduced Treg cell number" EXACT []
is_a: MP:0004972 ! abnormal regulatory T cell number
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0004975
name: absent regulatory T cells
def: "absence of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent suppressor T cells" EXACT []
synonym: "absent Treg cells" RELATED []
is_a: MP:0004974 ! decreased regulatory T cell number

[Term]
id: MP:0004976
name: abnormal B-1 B cell number
def: "deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal B1 cell number" EXACT []
is_a: MP:0004940 ! abnormal B-1 B cell morphology

[Term]
id: MP:0004977
name: increased B-1 B cell number
def: "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased B1 cell number" EXACT []
is_a: MP:0004976 ! abnormal B-1 B cell number
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0004978
name: decreased B-1 B cell number
def: "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased B1 cell number" EXACT []
synonym: "reduced B-1 B cell number" EXACT []
is_a: MP:0004976 ! abnormal B-1 B cell number
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0004979
name: abnormal neuronal precursor cell number
def: "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neuroblast cell number" EXACT []
synonym: "abnormal NPC number" EXACT []
synonym: "abnormal number of neural progenitor cells" EXACT []
is_a: MP:0008946 ! abnormal neuron number

[Term]
id: MP:0004980
name: increased neuronal precursor cell number
def: "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "expansion of neuronal precursor cells" EXACT []
synonym: "increased NPC number" EXACT []
synonym: "increased number of neuronal precursor cells" EXACT []
is_a: MP:0004979 ! abnormal neuronal precursor cell number

[Term]
id: MP:0004981
name: decreased neuronal precursor cell number
def: "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased NPC number" EXACT []
synonym: "reduced NPC number" EXACT []
synonym: "reduced number of neuronal precursor cells" EXACT []
is_a: MP:0004979 ! abnormal neuronal precursor cell number

[Term]
id: MP:0004982
name: abnormal osteoclast morphology
def: "any structural anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092]
synonym: "abnormal chondroclast morphology" RELATED []
synonym: "abnormal osteophage morphology" EXACT []
is_a: MP:0002446 ! abnormal macrophage morphology
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0004983
name: abnormal osteoclast cell number
def: "deviation from the average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal chondroclast cell number" RELATED []
is_a: MP:0004982 ! abnormal osteoclast morphology

[Term]
id: MP:0004984
name: increased osteoclast cell number
def: "greater than average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092]
synonym: "increased chondroclast cell number" RELATED []
is_a: MP:0004983 ! abnormal osteoclast cell number
is_a: MP:0005425 ! increased macrophage cell number

[Term]
id: MP:0004985
name: decreased osteoclast cell number
def: "reduced number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092]
synonym: "decreased chondroclast cell number" RELATED []
synonym: "reduced chondroclast cell number" RELATED []
synonym: "reduced osteoclast cell number" EXACT []
is_a: MP:0003884 ! decreased macrophage cell number
is_a: MP:0004983 ! abnormal osteoclast cell number

[Term]
id: MP:0004986
name: abnormal osteoblast morphology
def: "any structural anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell" [CL:0000062]
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0004987
name: abnormal osteoblast cell number
def: "deviation from the average number of the skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
is_a: MP:0004986 ! abnormal osteoblast morphology

[Term]
id: MP:0004988
name: increased osteoblast cell number
alt_id: MP:0002744
def: "greater than average number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
synonym: "increased osteoblast formation" EXACT []
is_a: MP:0004987 ! abnormal osteoblast cell number

[Term]
id: MP:0004989
name: decreased osteoblast cell number
alt_id: MP:0000058
def: "reduction in the number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
synonym: "decreased osteoblast formation" EXACT []
synonym: "reduced osteoblast cell number" EXACT []
synonym: "reduced osteoblast formation" EXACT []
is_a: MP:0004987 ! abnormal osteoblast cell number

[Term]
id: MP:0004990
name: abnormal ciliary ganglion morphology
def: "any structural anomaly of the parasympathetic ganglia in the orbit behind the eye that receives preganglionic innervation through the oculomotor nerve" [https://orcid.org/0009-0005-7755-8314]
synonym: "abnormal ciliary ganglia morphology" EXACT []
synonym: "abnormal lenticular ganglion morphology" EXACT []
synonym: "abnormal Schacher ganglion" EXACT []
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology
is_a: MP:0001081 ! abnormal cranial ganglia morphology

[Term]
id: MP:0004991
name: decreased bone strength
def: "reduced ability of bone to endure the application of force without yielding or breaking" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced bone strength" EXACT []
is_a: MP:0001542 ! abnormal bone strength

[Term]
id: MP:0004992
name: increased bone resorption
def: "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004945 ! abnormal bone resorption

[Term]
id: MP:0004993
name: decreased bone resorption
def: "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced bone resorption" EXACT []
is_a: MP:0004945 ! abnormal bone resorption

[Term]
id: MP:0004994
name: abnormal brain wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ECoG pattern" EXACT []
synonym: "abnormal EEG pattern" EXACT []
synonym: "abnormal electrocorticogram pattern" EXACT []
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0004995
name: abnormal B cell clonal deletion
def: "a defect in the process of removal by apoptosis of immature B lymphocytes that interact with self antigens during maturation" [MGI:acv]
is_a: MP:0004944 ! abnormal B cell negative selection
is_a: MP:0005001 ! abnormal clonal deletion

[Term]
id: MP:0004996
name: abnormal CNS synapse formation
def: "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0004997
name: increased CNS synapse formation
def: "greater frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004996 ! abnormal CNS synapse formation

[Term]
id: MP:0004998
name: decreased CNS synapse formation
def: "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced CNS synapse formation" EXACT []
is_a: MP:0004996 ! abnormal CNS synapse formation

[Term]
id: MP:0004999
name: abnormal blood-inner ear barrier function
def: "anomaly in the function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0005000
name: abnormal immune tolerance
def: "anomaly in the process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it" [GO:0002507, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0005001
name: abnormal clonal deletion
def: "a defect in the process of removal of immature lymphocytes that interact with self antigens during maturation" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "clonal deletion abnormalities" EXACT []
is_a: MP:0005000 ! abnormal immune tolerance

[Term]
id: MP:0005002
name: abnormal T cell clonal deletion
def: "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [ISBN:0-8153-1691-7]
synonym: "T cell clonal deletion abnormalities" EXACT []
synonym: "T lymphocyte clonal deletion abnormalities" EXACT []
synonym: "T-cell clonal deletion abnormalities" EXACT []
is_a: MP:0004918 ! abnormal negative T cell selection
is_a: MP:0005001 ! abnormal clonal deletion

[Term]
id: MP:0005003
name: obsolete B cell clonal deletion abnormalities
def: "OBSOLETE. a defect in the process of removal of immature B lymphocytes that interact with self antigens during maturation" [ISBN:0-8153-1691-7]
synonym: "B lymphocyte clonal deletion abnormalities" EXACT []
synonym: "B-cell clonal deletion abnormalities" EXACT []
is_obsolete: true

[Term]
id: MP:0005004
name: abnormal lymphocyte anergy
def: "anomaly in the process of establishing a state of functional inactivation of self-reactive lymphocytes" [GO:0002249, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal anergy" EXACT []
synonym: "abnormal clonal anergy" EXACT []
is_a: MP:0005000 ! abnormal immune tolerance

[Term]
id: MP:0005005
name: abnormal self tolerance
def: "a defect in the normal lack of response to autologous (self) antigens" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "self tolerance abnormalities" EXACT []
is_a: MP:0005000 ! abnormal immune tolerance

[Term]
id: MP:0005006
name: abnormal osteoblast physiology
def: "any functional anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell" [CL:0000062]
is_a: MP:0002998 ! abnormal bone remodeling
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0005009
name: obsolete congenital skeletal deformities
def: "OBSOLETE. malformations of the bones/skeleton existing at birth" [ISBN:0-683-40008-8]
is_obsolete: true

[Term]
id: MP:0005010
name: abnormal CD8-positive, alpha beta T cell morphology
def: "any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MESH:A11.118.637.555.567.569.220]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
synonym: "abnormal CD8+ T cell morphology" EXACT []
synonym: "abnormal CD8-positive T cell morphology" EXACT []
synonym: "abnormal single positive T cell morphology" BROAD []
synonym: "CD8+ T cell abnormalities" EXACT []
synonym: "CD8+ T-cell abnormalities" EXACT []
is_a: MP:0002435 ! abnormal effector T cell morphology
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology

[Term]
id: MP:0005011
name: increased eosinophil cell number
def: "greater than normal eosinophil numbers" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "eosinophilia" EXACT []
synonym: "increased eosinophil count" EXACT []
synonym: "increased eosinophil number" EXACT []
is_a: MP:0000322 ! increased granulocyte number
is_a: MP:0002602 ! abnormal eosinophil cell number

[Term]
id: MP:0005012
name: decreased eosinophil cell number
def: "fewer than normal eosinophil numbers" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased eosinophil count" EXACT []
synonym: "decreased eosinophil number" EXACT []
synonym: "reduced eosinophil cell number" EXACT []
is_a: MP:0000334 ! decreased granulocyte number
is_a: MP:0002602 ! abnormal eosinophil cell number

[Term]
id: MP:0005013
name: increased lymphocyte cell number
alt_id: MP:0000323
alt_id: MP:0000718
alt_id: MP:0000720
def: "greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased immune cell number" BROAD []
synonym: "increased lymphocyte count" EXACT []
synonym: "lymphocytosis" EXACT []
is_a: MP:0000218 ! increased leukocyte cell number
is_a: MP:0000717 ! abnormal lymphocyte cell number

[Term]
id: MP:0005014
name: increased B cell number
def: "greater than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased B cell count" EXACT []
synonym: "increased B lymphocyte count" EXACT []
synonym: "increased B lymphocyte number" EXACT []
synonym: "increased B-cell count" EXACT []
is_a: MP:0002458 ! abnormal B cell number
is_a: MP:0005013 ! increased lymphocyte cell number

[Term]
id: MP:0005015
name: increased T cell number
def: "greater than normal T cell numbers" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased T cell count" EXACT []
synonym: "increased T-cell count" EXACT []
is_a: MP:0005013 ! increased lymphocyte cell number
is_a: MP:0006387 ! abnormal T cell number

[Term]
id: MP:0005016
name: decreased lymphocyte cell number
alt_id: MP:0000335
alt_id: MP:0000722
alt_id: MP:0000724
def: "fewer than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased immune cell number" BROAD []
synonym: "decreased lymphocyte count" EXACT []
synonym: "lymphopenia" EXACT []
synonym: "reduced lymphocyte cell number" EXACT []
synonym: "reduced lymphocyte count" EXACT []
is_a: MP:0000221 ! decreased leukocyte cell number
is_a: MP:0000717 ! abnormal lymphocyte cell number

[Term]
id: MP:0005017
name: decreased B cell number
def: "fewer than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased B cell count" EXACT []
synonym: "decreased B lymphocyte count" EXACT []
synonym: "decreased B-cell count" EXACT []
synonym: "reduced B cell number" EXACT []
synonym: "reduced B lymphocyte count" EXACT []
is_a: MP:0002458 ! abnormal B cell number
is_a: MP:0005016 ! decreased lymphocyte cell number

[Term]
id: MP:0005018
name: decreased T cell number
def: "fewer than normal T cell numbers" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased T cell count" EXACT []
synonym: "decreased T-cell count" EXACT []
synonym: "decreased T-cell number" EXACT []
synonym: "reduced T cell number" EXACT []
synonym: "reduced T lymphocyte number" EXACT []
synonym: "reduced T-cell count" EXACT []
synonym: "reduced T-cell number" EXACT []
synonym: "reduced T-lymphocyte number" EXACT []
is_a: MP:0005016 ! decreased lymphocyte cell number
is_a: MP:0006387 ! abnormal T cell number

[Term]
id: MP:0005019
name: abnormal early pro-B cell
def: "any structural anomaly of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These cells express no surface Ig; cell surface markers for these cells are: CD45R, MHC class II, CD19, CD38, CD40.
synonym: "early pro-B cell abnormalities" EXACT []
synonym: "early pro-B-cell abnormalities" EXACT []
is_a: MP:0005432 ! abnormal pro-B cell morphology

[Term]
id: MP:0005020
name: abnormal late pro-B cell
def: "any structural anomaly of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These cells express no surface Ig; cell surface markers for these cells are: CD45R, MHC class II, CD19, CD38, CD40.
synonym: "late pro-B cell abnormalities" EXACT []
synonym: "late pro-B-cell abnormalities" EXACT []
is_a: MP:0005432 ! abnormal pro-B cell morphology

[Term]
id: MP:0005021
name: obsolete B lymphoblast abnormalities
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005022
name: abnormal immature B cell morphology
def: "any structural anomaly of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7, MGI:cwg]
comment: These cells express IgM on their surface, in addition to CD45R, MHC class II, CD19, CD20, CD21, CD40.
synonym: "immature B cell abnormalities" EXACT []
synonym: "immature B lymphocyte abnormalities" EXACT []
synonym: "immature B-cell abnormalities" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation

[Term]
id: MP:0005023
name: abnormal wound healing
def: "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0005025
name: abnormal response to infection
def: "any anomaly in the body's reaction to invasion and multiplication of microorganisms in its tissues, or the body's reaction to components of or toxins produced by pathogenic microorganisms" [MGI:cwg]
is_a: MP:0020000 ! abnormal response to antigen

[Term]
id: MP:0005026
name: decreased susceptibility to parasitic infection
def: "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites" [MGI:cwg]
synonym: "decreased susceptibility to parasite infection" EXACT []
synonym: "increased resistance to parasitic infection" EXACT []
synonym: "reduced susceptibility to parasitic infection" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0020184 ! abnormal susceptibility to parasitic infection

[Term]
id: MP:0005027
name: increased susceptibility to parasitic infection
def: "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites" [MGI:cwg]
synonym: "decreased resistance to parasitic infection" EXACT []
synonym: "increased susceptibility to parasite infection" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0020184 ! abnormal susceptibility to parasitic infection

[Term]
id: MP:0005028
name: abnormal trophectoderm morphology
def: "any structural anomaly outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition" [ISBN:0-683-40008-8, MGI:dlb]
is_a: MP:0004957 ! abnormal blastocyst morphology
is_a: MP:0011203 ! abnormal parietal yolk sac morphology

[Term]
id: MP:0005029
name: abnormal amnion morphology
def: "any structural anomaly of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0005030
name: absent amnion
def: "absence of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of amnion" EXACT []
is_a: MP:0005029 ! abnormal amnion morphology

[Term]
id: MP:0005031
name: abnormal trophoblast layer morphology
def: "any structural anomaly of the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta" [ISBN:0-683-40008-8]
synonym: "abnormal trophoblast" RELATED []
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0005032
name: abnormal ectoplacental cone morphology
def: "any structural anomaly of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta" [MGI:cwg]
synonym: "abnormal epamniotic cone" EXACT []
is_a: MP:0001711 ! abnormal placenta morphology
is_a: MP:0012056 ! abnormal polar trophectoderm morphology

[Term]
id: MP:0005033
name: abnormal trophoblast giant cell morphology
def: "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta" [ISBN:0-683-40008-8, MGI:dlb]
synonym: "abnormal trophoblast giant cells" BROAD []
is_a: MP:0005031 ! abnormal trophoblast layer morphology
is_a: MP:0012057 ! abnormal mural trophectoderm morphology

[Term]
id: MP:0005034
name: abnormal anus morphology
def: "any structural anomaly of the lower opening of the digestive tract" [ISBN:0-683-40008-8]
synonym: "abnormal anal opening morphology" EXACT []
synonym: "abnormal anal orifice morphology" EXACT []
synonym: "abnormal opening of terminal part of digestive tract morphology" EXACT []
synonym: "anus abnormalities" BROAD []
synonym: "anus dysplasia" NARROW []
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0005035
name: perianal ulcer
def: "lesion around or near the anus" [MGI:cml]
synonym: "perianal ulceration" EXACT []
is_a: MP:0005034 ! abnormal anus morphology

[Term]
id: MP:0005036
name: diarrhea
def: "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [ISBN:0-683-40008-8]
synonym: "diarrhoea" EXACT []
is_a: MP:0003866 ! abnormal defecation
is_a: MP:0014483 ! increased feces water content

[Term]
id: MP:0005037
name: mucous diarrhea
def: "presence of considerable mucous in the stools" [ISBN:0-683-40008-8]
synonym: "anal mucous discharge" EXACT []
synonym: "mucoid diarrhea" EXACT []
synonym: "mucous diarrhoea" EXACT []
is_a: MP:0005036 ! diarrhea

[Term]
id: MP:0005039
name: hypoxia
def: "reduced oxygenation of body tissues resulting in the decreased pressure of this component of body gases; commonly due to hypoxemia" [ISBN:978-0-387-75246-4]
synonym: "decreased tissue partial O2 level" EXACT []
is_a: MP:0001574 ! abnormal oxygen level

[Term]
id: MP:0005040
name: abnormal MHC II cell surface expression on macrophages
def: "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [J:31326, MGI:cwg]
is_a: MP:0002454 ! abnormal macrophage antigen presentation
is_a: MP:0005042 ! abnormal level of surface class II molecules

[Term]
id: MP:0005041
name: abnormal antigen presentation via MHC class II
alt_id: MP:0001843
def: "anomaly in the process by which peptide, bound to major histocompatibility complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [MGI:cwg]
is_a: MP:0001835 ! abnormal antigen presentation

[Term]
id: MP:0005042
name: abnormal level of surface class II molecules
def: "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [MGI:cwg]
comment: Unlike class I, which is expressed by almost all nucleated cells, only B cells, macrophages, other antigen presenting cells (e.g., Langerhans' cells), and epithelial cells of the thymus express MHC class II at their surface.
is_a: MP:0005041 ! abnormal antigen presentation via MHC class II

[Term]
id: MP:0005043
name: defective assembly of class II molecules
def: "impaired production of major histocompatibility complex class II molecules" [MGI:cwg]
is_a: MP:0005041 ! abnormal antigen presentation via MHC class II

[Term]
id: MP:0005044
name: sepsis
def: "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [ISBN:0-683-40008-8]
is_a: MP:0005025 ! abnormal response to infection

[Term]
id: MP:0005046
name: absent spleen white pulp
def: "absence of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent splenic white pulp" RELATED []
synonym: "failure of spleen white pulp formation" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0005047
name: enlarged celiac lymph nodes
def: "increased size of the celiac lymph nodes" [MGI:cwg]
synonym: "enlarged coeliac lymph nodes" EXACT []
synonym: "increased celiac lymph node size" EXACT []
synonym: "increased coeliac lymph node size" EXACT []
is_a: MP:0009626 ! abnormal celiac lymph node morphology

[Term]
id: MP:0005048
name: abnormal thrombosis
def: "any anomaly in the formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements" [ISBN:0-397-51047-0, MGI:cwg]
is_a: MP:0002551 ! abnormal blood coagulation

[Term]
id: MP:0005049
name: obsolete abnormal cytokine physiology
def: "OBSOLETE. functional anomaly of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7, MGI:cwg]
comment: This term is obsolete.  Instead, use the terms abnormal cytokine level (MP:0008713) and its children or abnormal cytokine secretion (MP:0003009) and its children.
is_obsolete: true
consider: MP:0003009
consider: MP:0008713

[Term]
id: MP:0005050
name: obsolete abnormal chemotactic interleukin physiology
def: "OBSOLETE. functional anomaly of any of a subset of interleukins that are involved in attracting leukocytes to a site of tissue injury" [MGI:cwg]
synonym: "chemotactic interleukins" EXACT []
is_obsolete: true

[Term]
id: MP:0005051
name: obsolete altered response to anesthetics
def: "OBSOLETE. a reaction that differs from normal to compounds that reversibly depress neuronal function" [MGI:cwg]
synonym: "altered sensitivity to anesthetics" EXACT []
is_obsolete: true

[Term]
id: MP:0005052
name: obsolete increased sleep after pentobarbital treatment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005053
name: obsolete altered response to pentobarbital
def: "OBSOLETE. a reaction to pentobarbital that differs from normal" [MGI:cwg]
synonym: "altered sensitivity to pentobarbital" EXACT []
is_obsolete: true

[Term]
id: MP:0005054
name: obsolete altered response to tribromoethanol
def: "OBSOLETE. a reaction to tribromoethanol that differs from normal" [MGI:cwg]
synonym: "altered sensitivity to tribromoethanol" EXACT []
is_obsolete: true

[Term]
id: MP:0005055
name: obsolete altered response to alphaxalone
def: "OBSOLETE. a reaction to alphaxalone that differs from controls" [MGI:cwg]
synonym: "altered sensitivity to alphaxalone" EXACT []
is_obsolete: true

[Term]
id: MP:0005056
name: obsolete increased sleep after tribromoethanol treatment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005057
name: obsolete increased sleep after alphaxalone treatment
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005058
name: abnormal lysosome morphology
def: "any structural anomaly of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal lysosome" EXACT []
xref: GO:0005764
is_a: MP:0020851 ! abnormal vacuole morphology

[Term]
id: MP:0005059
name: lysosomal protein accumulation
def: "buildup of protein in the lysosome" [MGI:cwg]
xref: GO:0007041
is_a: MP:0003172 ! abnormal lysosome physiology

[Term]
id: MP:0005060
name: accumulation of giant lysosomes in kidney/renal tubule cells
def: "buildup of contents in lysosomes in cells of the kidney tubules" [MGI:cwg, PMID:408]
comment: PMID:408 is correct.
is_a: MP:0002703 ! abnormal renal tubule morphology
is_a: MP:0005058 ! abnormal lysosome morphology

[Term]
id: MP:0005061
name: abnormal eosinophil morphology
def: "any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions" [CL:0000771, ISBN:0721601464]
synonym: "abnormal eosinocyte morphology" EXACT []
synonym: "abnormal eosinophilic leucocyte morphology" EXACT []
synonym: "abnormal eosinophilic leukocyte morphology" EXACT []
synonym: "abnormal polymorphonuclear leucocyte morphology" BROAD []
synonym: "abnormal polymorphonuclear leukocyte morphology" BROAD []
synonym: "eosinophil structural abnormalities" EXACT []
is_a: MP:0002414 ! abnormal myeloblast morphology/development
is_a: MP:0002441 ! abnormal granulocyte morphology

[Term]
id: MP:0005062
name: obsolete presence of giant granules in eosinophils
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005064
name: obsolete presence of giant granules in lymphocytes
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005065
name: abnormal neutrophil morphology
def: "any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [CL:0000775, ISBN:0721601464]
synonym: "abnormal neutrocyte morphology" EXACT []
synonym: "abnormal neutrophil leucocyte morphology" EXACT []
synonym: "abnormal neutrophil leukocyte morphology" EXACT []
synonym: "abnormal neutrophilic leucocyte morphology" EXACT []
synonym: "abnormal neutrophilic leukocyte morphology" EXACT []
synonym: "abnormal PMN morphology" BROAD []
synonym: "abnormal polymorphonuclear cell" EXACT []
synonym: "abnormal polymorphonuclear leucocyte morphology" BROAD []
synonym: "abnormal polymorphonuclear leukocyte morphology" BROAD []
synonym: "abnormal polymorphonuclear neutrophil morphology" BROAD []
synonym: "abnormal polynuclear neutrophilic leucocyte morphology" BROAD []
synonym: "abnormal polynuclear neutrophilic leukocyte morphology" BROAD []
synonym: "neutrophil structural abnormalities" EXACT []
is_a: MP:0002441 ! abnormal granulocyte morphology
is_a: MP:0008251 ! abnormal phagocyte morphology

[Term]
id: MP:0005066
name: obsolete presence of giant granules in neutrophils
def: "OBSOLETE." [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005067
name: obsolete presence of melanin granules in retina
def: "OBSOLETE. pigment particles found in retina" [https://orcid.org/0000-0003-3691-0324]
is_obsolete: true

[Term]
id: MP:0005068
name: abnormal NK cell morphology
def: "any structural anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
synonym: "abnormal natural killer cell" EXACT []
synonym: "abnormal NK cells" EXACT []
synonym: "natural killer cell abnormalities" EXACT []
synonym: "NK cell abnormalities" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0002619 ! abnormal lymphocyte morphology

[Term]
id: MP:0005070
name: impaired natural killer cell mediated cytotoxicity
def: "impaired ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors" [GO:0042267, ISBN:0-683-40008-8]
synonym: "defective natural killer cell cytolysis" EXACT []
synonym: "defective NK cell cytolysis" EXACT []
synonym: "impaired killer activity" BROAD []
synonym: "impaired natural killer cell mediated cell death" EXACT []
synonym: "impaired natural killer cell mediated cell killing" EXACT []
synonym: "impaired natural killer cell mediated cytolysis" EXACT []
synonym: "impaired natural killer-cell mediated cytolysis" EXACT []
synonym: "impaired NK cell cytolysis" EXACT []
synonym: "impaired NK cell mediated cell death" EXACT []
synonym: "impaired NK cell mediated cell killing" EXACT []
synonym: "impaired NK cell mediated cytolysis" EXACT []
synonym: "impaired NK cell mediated cytotoxicity" EXACT []
is_a: MP:0011719 ! abnormal natural killer cell mediated cytotoxicity

[Term]
id: MP:0005071
name: enlarged hair follicle melanin granules
def: "increased size of the pigment particles located in the hair follicle" [MGI:llw2]
synonym: "increased hair follicle melanin granule size" EXACT []
is_a: MP:0005072 ! abnormal hair follicle melanin granule morphology

[Term]
id: MP:0005072
name: abnormal hair follicle melanin granule morphology
def: "any structural anomaly of the pigment particles in the hair follicles" [MGI:cwg]
synonym: "hair follicle melanin granule abnormalities" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology
is_a: MP:0004381 ! abnormal hair follicle melanocyte morphology
is_a: MP:0005075 ! abnormal melanosome morphology

[Term]
id: MP:0005074
name: impaired granulocyte bactericidal activity
def: "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [J:5405, MGI:cwg]
synonym: "defective granulocyte bactericidal activity" EXACT []
is_a: MP:0002462 ! abnormal granulocyte physiology

[Term]
id: MP:0005075
name: abnormal melanosome morphology
def: "any structural anomaly of the tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [MGI:cwg]
synonym: "abnormal melanosome" EXACT []
xref: GO:0042470
is_a: MP:0002877 ! abnormal melanocyte morphology

[Term]
id: MP:0005076
name: abnormal cell differentiation
def: "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history" [MGI:cwg]
xref: GO:0030154
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0005077
name: abnormal melanogenesis
def: "anomaly in the biosynthetic pathway of melanin formation in cells" [J:5346, MGI:cwg]
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0005078
name: abnormal cytotoxic T cell physiology
def: "any functional anomaly of the subset of CD8-positive T lymphocytes capable of directly killing appropriately targeted cells" [MESH:A11.118.637.555.567.569.220.200]
synonym: "CTL dysfunction" EXACT []
synonym: "cytotoxic T cell dysfunction" EXACT []
synonym: "cytotoxic T lymphocyte dysfunction" EXACT []
synonym: "cytotoxic T-cell dysfunction" EXACT []
is_a: MP:0004392 ! abnormal CD8-positive, alpha-beta T cell physiology

[Term]
id: MP:0005079
name: decreased cytotoxic T cell cytolysis
def: "impaired ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane" [MGI:cwg]
synonym: "defective CTL cytolysis" EXACT []
synonym: "defective cytotoxic T cell cytolysis" EXACT []
synonym: "defective cytotoxic T lymphocyte cytolysis" EXACT []
synonym: "defective cytotoxic T-cell cytolysis" EXACT []
is_a: MP:0013280 ! abnormal cytotoxic T cell cytolysis

[Term]
id: MP:0005081
name: abnormal dermis reticular layer morphology
def: "any structural anomaly of the thicker, deeper layer of the dermis, comprised of criss-crossing collagen fibers that form a strong elastic network and also containing blood and lymph vessels, nerves and nerve endings, and hair follicles" [ISBN:0-683-40008-8]
synonym: "abnormal reticular layer morphology" EXACT []
synonym: "abnormal stratum reticulare corii" EXACT []
synonym: "abnormal stratum reticulare cutis" EXACT []
synonym: "abnormal stratum reticulare morphology" EXACT []
synonym: "abnormal tunica propria corii" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0005083
name: abnormal biliary tract morphology
def: "any structural anomaly of the gall bladder or its bile ducts" [MESH:A03.159]
synonym: "biliary tract dysplasia" NARROW []
is_a: MP:0002138 ! abnormal hepatobiliary system morphology

[Term]
id: MP:0005084
name: abnormal gallbladder morphology
def: "any structural anomaly of the organ which serves as a storage reservoir for bile" [ISBN:0-683-40008-8, MESH:A03.159.439]
comment: Note that rats, horses and deer do not have a gallbladder. Mice and human have a gallbladder.
synonym: "abnormal cholecyst morphology" RELATED []
synonym: "gall bladder dysplasia" NARROW []
synonym: "gallbladder abnormalities" BROAD []
is_a: MP:0002163 ! abnormal gland morphology
is_a: MP:0005083 ! abnormal biliary tract morphology

[Term]
id: MP:0005085
name: abnormal gallbladder physiology
def: "any functional anomaly of the organ that stores and concentrates bile" [ISBN:0-683-40008-8]
synonym: "abnormal gall bladder function" EXACT []
synonym: "abnormal gall bladder physiology" EXACT []
synonym: "abnormal gallbladder function" EXACT []
is_a: MP:0002139 ! abnormal hepatobiliary system physiology

[Term]
id: MP:0005087
name: decreased acute inflammation
def: "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response" [ISBN:0-397-51047-0]
synonym: "diminished acute inflammation" EXACT []
synonym: "diminished acute inflammatory response" EXACT []
synonym: "reduced acute inflammation" EXACT []
synonym: "reduced acute inflammatory response" EXACT []
is_a: MP:0001876 ! decreased inflammatory response
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0005088
name: increased acute inflammation
def: "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response" [ISBN:0-397-51047-0]
synonym: "increased acute inflammatory response" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002498 ! abnormal acute inflammation

[Term]
id: MP:0005089
name: decreased double-negative T cell number
def: "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [ISBN:0-8153-1691-7]
synonym: "decreased CD4-CD8- T cell count" EXACT []
synonym: "decreased CD4-CD8- T cell numbers" EXACT []
synonym: "decreased double negative T cell number" EXACT []
synonym: "decreased double-negative T cell count" EXACT []
synonym: "decreased double-negative T cell numbers" EXACT []
synonym: "decreased double-negative T-cell numbers" EXACT []
synonym: "reduced CD4-CD8- T cell count" EXACT []
synonym: "reduced CD4-CD8- T cell numbers" EXACT []
synonym: "reduced double negative T cell number" EXACT []
synonym: "reduced double-negative T cell count" EXACT []
synonym: "reduced double-negative T cell numbers" EXACT []
synonym: "reduced double-negative T-cell numbers" EXACT []
is_a: MP:0002407 ! abnormal double-negative T cell morphology
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0005090
name: increased double-negative T cell number
def: "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [ISBN:0-8153-1691-7]
synonym: "increased CD4-CD8- T cell count" EXACT []
synonym: "increased double negative T cell number" EXACT []
synonym: "increased double-negative T cell count" EXACT []
synonym: "increased double-negative T cell numbers" EXACT []
synonym: "increased double-negative T-cell numbers" EXACT []
synonym: "increased numbers of CD4-CD8- T cells" EXACT []
synonym: "increased numbers of double-negative T cells" EXACT []
is_a: MP:0002407 ! abnormal double-negative T cell morphology
is_a: MP:0005015 ! increased T cell number

[Term]
id: MP:0005091
name: increased double-positive T cell number
def: "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [ISBN:0-8153-1691-7]
synonym: "increased CD4+CD8+ T cell count" EXACT []
synonym: "increased CD4+CD8+ T cell numbers" EXACT []
synonym: "increased double positive T cell number" EXACT []
synonym: "increased double-positive T cell count" EXACT []
synonym: "increased double-positive T cell numbers" EXACT []
synonym: "increased double-positive T-cell numbers" EXACT []
is_a: MP:0002408 ! abnormal double-positive T cell morphology
is_a: MP:0005015 ! increased T cell number

[Term]
id: MP:0005092
name: decreased double-positive T cell number
def: "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [ISBN:0-8153-1691-7]
synonym: "decreased CD4+CD8+ T cell count" EXACT []
synonym: "decreased CD4+CD8+ T cell numbers" EXACT []
synonym: "decreased double positive T cell number" EXACT []
synonym: "decreased double-positive T cell count" EXACT []
synonym: "decreased double-positive T cell numbers" EXACT []
synonym: "decreased double-positive T-cell numbers" EXACT []
synonym: "reduced CD4+CD8+ T cell count" EXACT []
synonym: "reduced CD4+CD8+ T cell numbers" EXACT []
synonym: "reduced double positive T cell number" EXACT []
synonym: "reduced double-positive T cell count" EXACT []
synonym: "reduced double-positive T cell numbers" EXACT []
synonym: "reduced double-positive T-cell numbers" EXACT []
is_a: MP:0002408 ! abnormal double-positive T cell morphology
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0005093
name: decreased B cell proliferation
def: "absent or reduced expansion rate of the B cell population by cell division in response to stimuli" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "B cell hypoproliferation" EXACT []
synonym: "B lymphocyte hypoproliferation" EXACT []
synonym: "decreased B lymphocyte proliferation" EXACT []
synonym: "defective B cell proliferation" EXACT []
synonym: "defective B-cell proliferation" EXACT []
synonym: "impaired B cell proliferation" RELATED []
synonym: "reduced B cell proliferation" EXACT []
synonym: "reduced B lymphocyte proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0005153 ! abnormal B cell proliferation

[Term]
id: MP:0005094
name: abnormal T cell proliferation
def: "anomaly in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli" [ISBN:0-8153-1691-7]
synonym: "abnormal T-cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0001828 ! abnormal T cell activation

[Term]
id: MP:0005095
name: decreased T cell proliferation
def: "reduction in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli" [ISBN:0-8153-1691-7]
synonym: "decreased T-cell proliferation" EXACT []
synonym: "impaired T cell proliferation" EXACT []
synonym: "impaired T-cell proliferation" EXACT []
synonym: "reduced T cell proliferation" EXACT []
synonym: "reduced T-cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0005094 ! abnormal T cell proliferation

[Term]
id: MP:0005096
name: erythroblastosis
def: "presence of erythroblasts in great number in the blood" [ISBN:0-683-40008-8]
is_a: MP:0011178 ! increased erythroblast number

[Term]
id: MP:0005097
name: polychromatophilia
def: "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [ISBN:0-683-40008-8]
synonym: "polychromasia" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0005098
name: abnormal optic choroid morphology
def: "any structural anomaly of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [ISBN:0-683-40008-8]
synonym: "abnormal choroid morphology" EXACT []
synonym: "abnormal posterior uvea morphology" EXACT []
synonym: "abnormal tunica vasculosa bulbi morphology" EXACT []
synonym: "abnormal uveal tract morphology" EXACT []
synonym: "abnormal vascular layer of the eyeball morphology" EXACT []
synonym: "choroid dysplasia" NARROW []
synonym: "tunica vasculosa oculi abnormalities" EXACT []
synonym: "vascular tunic of the eye abnormalities" BROAD []
is_a: MP:0005197 ! abnormal uvea morphology

[Term]
id: MP:0005099
name: abnormal ciliary body morphology
def: "any structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris, and is made up of the ciliary muscle and the ciliary processes; the processes radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "ciliary body abnormalities" EXACT []
is_a: MP:0005194 ! abnormal anterior uvea morphology

[Term]
id: MP:0005100
name: abnormal choroid pigmentation
def: "anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [ISBN:0-683-40008-8]
synonym: "abnormal uveal pigmentation" EXACT []
is_a: MP:0001324 ! abnormal eye pigmentation
is_a: MP:0005098 ! abnormal optic choroid morphology

[Term]
id: MP:0005101
name: abnormal ciliary body pigmentation
def: "anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [ISBN:0-683-40008-8]
is_a: MP:0001324 ! abnormal eye pigmentation
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0005102
name: abnormal iris pigmentation
def: "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001322 ! abnormal iris morphology
is_a: MP:0001324 ! abnormal eye pigmentation

[Term]
id: MP:0005103
name: abnormal retina pigmentation
def: "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal retinal pigmentation" EXACT []
is_a: MP:0005201 ! abnormal retina pigment epithelium morphology

[Term]
id: MP:0005104
name: abnormal tarsal bone morphology
def: "any structural anomaly of any of the eight bones of the instep of the paw/foot: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [ISBN:0-683-40008-8, ISBN:978-0028454405]
comment: Note that humans only have seven tarsal bones, while rodents have eight. The tibiale is not present in humans.
synonym: "abnormal tarsals morphology" EXACT []
synonym: "abnormal tarsus morphology" EXACT []
synonym: "tarsal bone dysplasia" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0002115 ! abnormal limb bone morphology

[Term]
id: MP:0005105
name: abnormal middle ear ossicle morphology
alt_id: MP:0003738
def: "any structural anomaly of the three small bones of the middle ear" [ISBN:0-683-40008-8]
synonym: "abnormal middle ear bone morphology" EXACT []
synonym: "abnormal middle ear ossicles morphology" EXACT []
synonym: "middle ear bone abnormalities" BROAD []
synonym: "middle ear ossicle dysplasia" NARROW []
is_a: MP:0000049 ! abnormal middle ear morphology
is_a: MP:0002116 ! abnormal craniofacial bone morphology

[Term]
id: MP:0005106
name: abnormal incus morphology
def: "any structural anomaly of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially; its parts include: a body which articulates with the head of the malleus, and to which the superior ligament of the incus is attached (to the roof of the middle ear cavity); a long crus down to the lentiform process (lenticular process) which articulates with the stapes; and a short crus to which the posterior ligament of the incus is attached" [ISBN:0-683-40008-8]
synonym: "abnormal incus bone morphology" EXACT []
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0005107
name: abnormal stapes morphology
def: "any structural anomaly of the smallest and innermost of the three auditory ossicles" [ISBN:0-683-40008-8]
synonym: "abnormal stapes" EXACT []
is_a: MP:0005105 ! abnormal middle ear ossicle morphology

[Term]
id: MP:0005108
name: abnormal ulna morphology
def: "any structural anomaly of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "ulna dysplasia" NARROW []
is_a: MP:0003855 ! abnormal forelimb zeugopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0005109
name: abnormal talus morphology
def: "any structural anomaly of the bone that articulates with the tibia and fibula" [ISBN:0-683-40008-8]
synonym: "abnormal ankle bone morphology" BROAD []
synonym: "abnormal astragalus morphology" EXACT []
synonym: "talus dysplasia" NARROW []
is_a: MP:0005104 ! abnormal tarsal bone morphology

[Term]
id: MP:0005110
name: absent talus
def: "absence of the bone that articulates with the tibia and fibula" [ISBN:0-683-40008-8]
is_a: MP:0005109 ! abnormal talus morphology

[Term]
id: MP:0005111
name: hyperdipsia
def: "intense thirst that is relatively temporary" [ISBN:0-683-40008-8, J:83217]
is_a: MP:0001422 ! abnormal drinking behavior

[Term]
id: MP:0005112
name: abnormal spinal cord ventral horn morphology
def: "any structural anomaly of the ventral grey column of the spinal cord" [ISBN:0-683-40008-8]
comment: Note that the synonym anterior column may refer to either the grey matter ventral horn or the white matter ventral column in the spinal cord. The synonym anterior horn may also refer to a region of the brain lateral ventricles.
synonym: "abnormal anterior column morphology" EXACT []
synonym: "abnormal anterior horn morphology" EXACT []
synonym: "abnormal ventral horn morphology" EXACT []
xref: MA:0001134
is_a: MP:0008503 ! abnormal spinal cord grey matter morphology

[Term]
id: MP:0005113
name: decreased spinal cord ventral horn cell number
def: "fewer than the expected number of cells in the ventral grey column of the spinal cord" [ISBN:0-683-40008-8]
comment: The synonym anterior horn may also refer to a region of the brain lateral ventricles.
synonym: "decreased anterior column cell number" EXACT []
synonym: "decreased anterior horn cell number" EXACT []
synonym: "decreased number of anterior horn cells" EXACT []
synonym: "decreased spinal cord anterior horn cell number" EXACT []
synonym: "reduced anterior horn cell number" EXACT []
is_a: MP:0005112 ! abnormal spinal cord ventral horn morphology

[Term]
id: MP:0005114
name: premature hair loss
def: "release of fur at an earlier than expected time" [MGI:cwg]
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0005116
name: abnormal circulating pituitary hormone level
alt_id: MP:0005115
def: "aberration in the blood concentration of any of the hormones secreted by the pituitary" [MGI:cwg]
synonym: "abnormal circulating level of pituitary hormone" EXACT []
synonym: "abnormal serum level of pituitary hormone" NARROW []
is_a: MP:0003965 ! abnormal pituitary hormone level
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005117
name: increased circulating pituitary hormone level
def: "greater than expected concentration of any of the pituitary hormones in the blood" [MGI:cwg]
synonym: "increased serum level of pituitary hormone" NARROW []
is_a: MP:0003973 ! increased pituitary hormone level
is_a: MP:0005116 ! abnormal circulating pituitary hormone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005118
name: decreased circulating pituitary hormone level
def: "less than expected concentration of any of the pituitary hormones found in the blood" [MGI:cwg]
synonym: "decreased serum levels of pituitary hormone" NARROW []
synonym: "reduced circulating pituitary hormone level" EXACT []
is_a: MP:0003972 ! decreased pituitary hormone level
is_a: MP:0005116 ! abnormal circulating pituitary hormone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005119
name: decreased circulating thyroid-stimulating hormone level
def: "reduced amount in the blood of the hormone that stimulates the growth and function of the thyroid gland" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of thyroid-stimulating hormone" NARROW []
synonym: "decreased serum levels of thyropic hormone" NARROW []
synonym: "decreased serum levels of thyrotrophin" NARROW []
synonym: "decreased serum levels of thyrotropin" NARROW []
synonym: "decreased serum levels of TSH" NARROW []
synonym: "reduced circulating thyroid-stimulating hormone" EXACT []
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005134 ! decreased thyroid-stimulating hormone level

[Term]
id: MP:0005120
name: decreased circulating growth hormone level
def: "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [ISBN:0-683-40008-8]
synonym: "decreased serum levels of GH" NARROW []
synonym: "decreased serum levels of growth hormone" NARROW []
synonym: "decreased serum levels of somatotropic hormone" NARROW []
synonym: "decreased serum levels of somatropin" NARROW []
synonym: "reduced circulating growth hormone level" EXACT []
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005136 ! decreased growth hormone level

[Term]
id: MP:0005121
name: decreased circulating prolactin level
def: "less than expected blood concentration of the hormone that stimulates milk secretion" [ISBN:0-683-40008-8]
synonym: "decreased circulating mammotropin level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "decreased serum levels of galactopoietic hormone" NARROW []
synonym: "decreased serum levels of lactation hormone" NARROW []
synonym: "decreased serum levels of lactogenic hormone" NARROW [MESH:D06.472.699.322.576.773]
synonym: "decreased serum levels of lactotropin" NARROW []
synonym: "decreased serum levels of mammotropic factor" NARROW []
synonym: "decreased serum levels of mammotropic hormone" NARROW [MESH:D06.472.699.322.576.773]
synonym: "decreased serum levels of PRL" NARROW [MESH:D06.472.699.322.576.773]
synonym: "decreased serum levels of prolactin" NARROW []
synonym: "hypoprolactinaemia" EXACT []
synonym: "hypoprolactinemia" EXACT []
synonym: "reduced circulating prolactin level" EXACT []
is_a: MP:0003363 ! decreased circulating gonadotropin level
is_a: MP:0005118 ! decreased circulating pituitary hormone level
is_a: MP:0005138 ! decreased prolactin level

[Term]
id: MP:0005122
name: increased circulating thyroid-stimulating hormone level
def: "greater amount in the blood of the hormone that stimulates the growth and function of the thyroid gland" [ISBN:0-683-40008-8]
synonym: "increased serum levels of thyroid-stimulating hormone" NARROW []
synonym: "increased serum levels of thyrotrophin" NARROW []
synonym: "increased serum levels of thyrotropic hormone" NARROW []
synonym: "increased serum levels of thyrotropin" NARROW []
synonym: "increased serum levels of TSH" NARROW []
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005135 ! increased thyroid-stimulating hormone level

[Term]
id: MP:0005123
name: increased circulating growth hormone level
def: "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [ISBN:0-683-40008-8]
synonym: "increased serum levels of GH" NARROW []
synonym: "increased serum levels of growth hormone" NARROW []
synonym: "increased serum levels of somatotropic hormone" NARROW []
synonym: "increased serum levels of somatotropin" NARROW []
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005137 ! increased growth hormone level

[Term]
id: MP:0005124
name: increased circulating prolactin level
def: "greater than expected blood concentration of the hormone that stimulates milk secretion" [ISBN:0-683-40008-8]
synonym: "hyperprolactinaemia" EXACT []
synonym: "hyperprolactinemia" EXACT []
synonym: "increased serum levels of galactopoietic hormone" NARROW []
synonym: "increased serum levels of lactation hormone" NARROW []
synonym: "increased serum levels of lactogenic hormone" NARROW []
synonym: "increased serum levels of lactotropin" NARROW []
synonym: "increased serum levels of mammotropic factor" NARROW []
synonym: "increased serum levels of mammotropic hormone" NARROW []
synonym: "increased serum levels of PRL" NARROW []
synonym: "increased serum levels of prolactin" NARROW []
is_a: MP:0003362 ! increased circulating gonadotropin level
is_a: MP:0005117 ! increased circulating pituitary hormone level
is_a: MP:0005139 ! increased prolactin level

[Term]
id: MP:0005128
name: decreased adrenocorticotropin level
def: "decreased concentration of adrenocorticotropic hormone" [ISBN:0-683-40008-8]
synonym: "decreased level of ACTH" EXACT []
synonym: "decreased level of adrenocorticotropic hormone" EXACT []
synonym: "decreased level of adrenocorticotropin" EXACT []
synonym: "decreased level of adrenotropic hormone" EXACT []
synonym: "decreased level of adrenotropin" EXACT []
synonym: "decreased pituitary levels of ACTH" NARROW []
synonym: "decreased pituitary levels of adrenocorticotropin" NARROW []
synonym: "reduced adrenocorticotropin level" EXACT []
is_a: MP:0003966 ! abnormal adrenocorticotropin level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005129
name: increased adrenocorticotropin level
def: "increased concentration of adrenocorticotropic hormone" [ISBN:0-683-40008-8]
synonym: "increased level of ACTH" EXACT []
synonym: "increased level of adrenocorticotropic hormone" EXACT []
synonym: "increased level of adrenocorticotropin" EXACT []
synonym: "increased level of adrenotropic hormone" EXACT []
synonym: "increased level of adrenotropin" EXACT []
synonym: "increased pituitary levels of ACTH" NARROW []
synonym: "increased pituitary levels of adrenocorticotropin" NARROW []
is_a: MP:0003966 ! abnormal adrenocorticotropin level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005130
name: decreased follicle stimulating hormone level
def: "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8]
synonym: "decreased pituitary levels of follicle stimulating hormone" EXACT []
synonym: "decreased pituitary levels of FSH" EXACT []
synonym: "reduced follicle stimulating hormone level" EXACT []
is_a: MP:0003967 ! abnormal follicle stimulating hormone level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005131
name: increased follicle stimulating hormone level
def: "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [ISBN:0-683-40008-8]
synonym: "increased pituitary levels of follicle stimulating hormone" EXACT []
synonym: "increased pituitary levels of FSH" EXACT []
is_a: MP:0003967 ! abnormal follicle stimulating hormone level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005132
name: decreased luteinizing hormone level
def: "lower than normal concentration of LH" [ISBN:0-683-40008-8]
synonym: "decreased luteinising hormone level" EXACT []
synonym: "decreased pituitary levels of LH" NARROW []
synonym: "decreased pituitary levels of luteinising hormone" NARROW []
synonym: "decreased pituitary levels of luteinizing hormone" NARROW []
synonym: "reduced luteinising hormone level" EXACT []
synonym: "reduced luteinizing hormone level" EXACT []
is_a: MP:0003969 ! abnormal luteinizing hormone level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005133
name: increased luteinizing hormone level
def: "higher than normal levels of LH" [ISBN:0-683-40008-8]
synonym: "increased luteinising hormone level" EXACT []
synonym: "increased pituitary levels of LH" NARROW []
synonym: "increased pituitary levels of luteinising hormone" NARROW []
synonym: "increased pituitary levels of luteinizing hormone" NARROW []
is_a: MP:0003969 ! abnormal luteinizing hormone level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005134
name: decreased thyroid-stimulating hormone level
def: "reduced amount of the hormone that stimulates the growth and function of the thyroid gland" [ISBN:0-683-40008-8]
synonym: "decreased pituitary levels of thyroid-stimulating hormone" NARROW []
synonym: "decreased pituitary levels of TSH" NARROW []
synonym: "decreased thyropic hormone level" EXACT []
synonym: "decreased thyrotrophin level" EXACT []
synonym: "decreased thyrotropin level" EXACT []
synonym: "decreased TSH level" EXACT []
synonym: "reduced thyroid-stimulating hormone level" EXACT []
is_a: MP:0003971 ! abnormal thyroid-stimulating hormone level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005135
name: increased thyroid-stimulating hormone level
def: "greater amount of the hormone that stimulates the growth and function of the thyroid gland" [ISBN:0-683-40008-8]
synonym: "increased pituitary levels of thyroid-stimulating hormone" NARROW []
synonym: "increased pituitary levels of TSH" NARROW []
synonym: "increased thyropic hormone level" EXACT []
synonym: "increased thyrotrophin level" EXACT []
synonym: "increased thyrotropin level" EXACT []
synonym: "increased TSH level" EXACT []
is_a: MP:0003971 ! abnormal thyroid-stimulating hormone level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005136
name: decreased growth hormone level
def: "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [ISBN:0-683-40008-8]
synonym: "decreased level of GH" EXACT []
synonym: "decreased level of growth hormone" EXACT []
synonym: "decreased level of pituitary growth hormone" EXACT []
synonym: "decreased level of somatotropic hormone" EXACT []
synonym: "decreased level of somatotropin" EXACT []
synonym: "decreased pituitary levels of GH" NARROW []
synonym: "decreased pituitary levels of growth hormone" NARROW []
synonym: "reduced growth hormone level" EXACT []
is_a: MP:0003968 ! abnormal growth hormone level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005137
name: increased growth hormone level
def: "greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [ISBN:0-683-40008-8]
synonym: "increased level of GH" EXACT []
synonym: "increased level of growth hormone" EXACT []
synonym: "increased level of pituitary growth hormone" EXACT []
synonym: "increased level of somatotropic hormone" EXACT []
synonym: "increased level of somatotropin" EXACT []
synonym: "increased pituitary levels of GH" NARROW []
synonym: "increased pituitary levels of growth hormone" NARROW []
is_a: MP:0003968 ! abnormal growth hormone level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005138
name: decreased prolactin level
def: "less than expected concentration of the hormone that stimulates milk secretion" [ISBN:0-683-40008-8]
synonym: "decreased galactopoietic hormone level" EXACT []
synonym: "decreased lactation hormone level" EXACT []
synonym: "decreased lactogenic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "decreased lactotropin level" EXACT []
synonym: "decreased mammotropic factor level" EXACT []
synonym: "decreased mammotropic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "decreased mammotropin level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "decreased pituitary levels of PRL" NARROW []
synonym: "decreased pituitary levels of prolactin" NARROW []
synonym: "decreased PRL level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "reduced prolactin level" EXACT []
is_a: MP:0003970 ! abnormal prolactin level
is_a: MP:0003972 ! decreased pituitary hormone level

[Term]
id: MP:0005139
name: increased prolactin level
def: "greater than expected concentration of the hormone that stimulates milk secretion" [ISBN:0-683-40008-8]
synonym: "increased galactopoietic hormone level" EXACT []
synonym: "increased lactation hormone level" EXACT []
synonym: "increased lactogenic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "increased lactotropin level" EXACT []
synonym: "increased mammotropic factor level" EXACT []
synonym: "increased mammotropic hormone level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "increased mammotropin level" EXACT [MESH:D06.472.699.322.576.773]
synonym: "increased pituitary levels of PRL" NARROW []
synonym: "increased pituitary levels of prolactin" NARROW []
synonym: "increased PRL level" EXACT [MESH:D06.472.699.322.576.773]
is_a: MP:0003970 ! abnormal prolactin level
is_a: MP:0003973 ! increased pituitary hormone level

[Term]
id: MP:0005140
name: decreased cardiac muscle contractility
alt_id: MP:0002974
def: "inability or reduced ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume" [ISBN:0-683-40008-8]
synonym: "decreased cardiac muscle contraction" EXACT []
synonym: "impaired cardiac contractility" EXACT []
synonym: "impaired cardiac muscle contractility" EXACT []
synonym: "reduced cardiac contractility" EXACT []
synonym: "reduced cardiac muscle contractility" EXACT []
synonym: "reduced fractional shortening (FS)" NARROW []
synonym: "reduced peak of aortic outflow velocity (PAV)" NARROW []
synonym: "reduced velocity of circumferential fiber shortening (Vcfc)" NARROW []
synonym: "reduced velocity of circumferential fibre shortening (Vcfc)" NARROW []
synonym: "reduced ventricular ejection fraction volume" NARROW []
is_a: MP:0000738 ! impaired muscle contractility
is_a: MP:0002972 ! abnormal cardiac muscle contractility

[Term]
id: MP:0005141
name: liver hyperplasia
def: "increase in the number of normal cells in normal arrangement in the liver, typically resulting in increased size" [MGI:cwg]
synonym: "hepatic hyperplasia" EXACT []
synonym: "hyperplastic liver" EXACT []
is_a: MP:0000599 ! enlarged liver

[Term]
id: MP:0005144
name: abnormal circulating VLDL cholesterol level
def: "any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal blood VLDL cholesterol level" EXACT []
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0020151 ! abnormal circulating non-HDL cholesterol level

[Term]
id: MP:0005145
name: increased circulating VLDL cholesterol level
def: "greater amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "elevated circulating VLDL cholesterol level" EXACT []
synonym: "elevated VLDL cholesterol level" BROAD []
synonym: "increased VLDL cholesterol level" BROAD []
is_a: MP:0005144 ! abnormal circulating VLDL cholesterol level
is_a: MP:0005178 ! increased circulating cholesterol level

[Term]
id: MP:0005146
name: decreased circulating VLDL cholesterol level
def: "reduced amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased VLDL cholesterol level" BROAD []
synonym: "low VLDL cholesterol level" BROAD []
synonym: "reduced circulating VLDL cholesterol level" EXACT []
synonym: "reduced VLDL cholesterol level" BROAD []
is_a: MP:0005144 ! abnormal circulating VLDL cholesterol level
is_a: MP:0005179 ! decreased circulating cholesterol level

[Term]
id: MP:0005147
name: prostate gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the prostate gland, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic prostate gland" EXACT []
is_a: MP:0002774 ! small prostate gland

[Term]
id: MP:0005148
name: seminal vesicle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the seminal vesicle, typically resulting in decreased size" [MGI:cwg]
synonym: "hypoplastic seminal gland" EXACT []
synonym: "hypoplastic seminal vesicle" EXACT []
synonym: "seminal gland hypoplasia" EXACT []
is_a: MP:0001157 ! small seminal vesicle

[Term]
id: MP:0005149
name: abnormal gubernaculum morphology
def: "any structural anomaly of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus" [ISBN:0-683-40008-8]
synonym: "abnormal caudal suspensory ligament morphology" EXACT []
synonym: "abnormal gubernaculae" BROAD []
synonym: "gubernaculum dysplasia" NARROW []
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0005504 ! abnormal ligament morphology

[Term]
id: MP:0005150
name: cachexia
def: "general weight loss and wasting occurring in the course of chronic disease" [ISBN:0-683-40008-8]
synonym: "emaciation" EXACT []
synonym: "wasting" EXACT []
is_a: MP:0001263 ! weight loss

[Term]
id: MP:0005151
name: diffuse hepatic necrosis
def: "morphological changes resulting from disseminated pathological death of some or all liver tissue; usually due to irreversible damage" [ISBN:0-683-40008-8]
synonym: "diffuse liver necrosis" EXACT []
synonym: "diffusely necrotic liver" EXACT []
is_a: MP:0001654 ! hepatic necrosis

[Term]
id: MP:0005152
name: pancytopenia
def: "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [ISBN:0-683-40008-8]
is_a: MP:0011182 ! decreased hematopoietic cell number

[Term]
id: MP:0005153
name: abnormal B cell proliferation
def: "anomaly in the ability of the B cell population to undergo rapid expansion by cell division in response to stimuli" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "abnormal B lymphocyte proliferation" EXACT []
synonym: "abnormal B-cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0008217 ! abnormal B cell activation

[Term]
id: MP:0005154
name: increased B cell proliferation
def: "greater than normal expansion rate of the B cell population by cell division in response to stimuli" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "B cell hyperproliferation" EXACT []
synonym: "B-cell hyperproliferation" EXACT []
synonym: "enhanced B cell proliferation" EXACT []
synonym: "enhanced B-cell proliferation" EXACT []
synonym: "increased B-cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0005153 ! abnormal B cell proliferation

[Term]
id: MP:0005155
name: herniated intestine
def: "protrusion of any portion of the intestine from its normal anatomical position" [ISBN:0-683-40008-8]
synonym: "intestinal hernia" EXACT []
synonym: "intestinal herniation" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0005156
name: bradykinesia
def: "decreased spontaneity and movement, without external stimulus" [ISBN:0-683-40008-8]
synonym: "bradycinesia" EXACT []
synonym: "hypokinesia" RELATED []
synonym: "reduced spontaneous movement" EXACT []
is_a: MP:0031392 ! hypoactivity

[Term]
id: MP:0005157
name: holoprosencephaly
def: "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [ISBN:0-683-40008-8]
subset: CvDC_Terms
subset: IMPC_Prenatal
synonym: "HPE" EXACT []
xref: Fyler:4338
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0005158
name: ovary hypoplasia
alt_id: MP:0003583
def: "decrease in the number of normal cells in normal arrangement in the ovary, typically resulting in decreased size" [MGI:cwg]
synonym: "hypoplastic ovaries" EXACT []
synonym: "hypoplastic ovary" EXACT []
synonym: "ovarian hypoplasia" EXACT []
synonym: "rudimentary ovary" EXACT []
is_a: MP:0001127 ! small ovary

[Term]
id: MP:0005159
name: azoospermia
def: "a condition where there is no measurable level of spermatozoa in the semen" [MGI:llw2]
synonym: "absence of sperm" EXACT []
synonym: "absent sperm" EXACT []
synonym: "aspermia" EXACT []
is_a: MP:0001117 ! absent gametes
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0002673 ! abnormal sperm number
is_a: MP:0004901 ! decreased male germ cell number

[Term]
id: MP:0005161
name: hematuria
def: "presence of blood in the urine" [ISBN:0-683-40008-8]
synonym: "haematuria" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0005162
name: carpoptosis
def: "paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve" [ISBN:0-683-40008-8]
synonym: "carpoptosia" EXACT []
synonym: "drop hand" EXACT []
synonym: "drop wrist" EXACT []
synonym: "wrist drop" EXACT []
is_a: MP:0000753 ! paralysis

[Term]
id: MP:0005163
name: cyclopia
def: "a congenital defect characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities; cyclopia is a rare form of holoprosencephaly that typically presents with a median single eye or a partially divided eye in a single orbit, absent nose, and a proboscis above the eye" [ISBN:0-683-40008-8, PMID:25698887]
synonym: "cyclocephaly" EXACT []
synonym: "cyclopea" EXACT []
synonym: "Cyclops eye" EXACT []
synonym: "one eye" EXACT []
synonym: "single central eye" EXACT []
synonym: "synophthalmia" EXACT []
synonym: "synophthalmus" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0005164
name: abnormal response to injury
def: "anomaly in the body's reaction to trauma, especially that by physical means" [ISBN:0-683-40008-8]
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0005165
name: increased susceptibility to injury
def: "greater than the normal reaction to trauma, especially that by physical means" [ISBN:0-683-40008-8]
synonym: "decreased resistance to injury" EXACT []
synonym: "increased response to injury" EXACT []
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0005166
name: decreased susceptibility to injury
def: "less than the normal reaction to trauma, especially that by physical means" [ISBN:0-683-40008-8]
synonym: "decreased response to injury" EXACT []
synonym: "increased resistance to injury" EXACT []
synonym: "reduced susceptibility to injury" EXACT []
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0005167
name: abnormal blood-brain barrier function
def: "anomaly in the function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [ISBN:0-683-40008-8]
synonym: "abnormal BBB function" EXACT []
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0005168
name: abnormal female meiosis
def: "anomaly in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8]
xref: GO:0007143
is_a: MP:0001930 ! abnormal meiosis
is_a: MP:0001931 ! abnormal oogenesis

[Term]
id: MP:0005169
name: abnormal male meiosis
def: "anomaly in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8]
xref: GO:0007140
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0005170
name: cleft upper lip
def: "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MESH:C07.465.409.225]
subset: CvDC_Terms
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "cheiloschisis" EXACT []
synonym: "cleft lip" BROAD []
synonym: "harelip" EXACT []
xref: Fyler:4875
is_a: MP:0003771 ! abnormal lip shape
is_a: MP:0012523 ! abnormal upper lip morphology
is_a: MP:0021164 ! oral cleft

[Term]
id: MP:0005171
name: absent coat pigmentation
def: "fur or hair is devoid of coloration and appears white" [MGI:cwg]
synonym: "absent fur pigmentation" RELATED []
synonym: "absent hair pigmentation" EXACT []
synonym: "albino coat" EXACT []
synonym: "lack of coat pigmentation" EXACT []
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0005172
name: decreased eye pigmentation
def: "the eye has less pigmentation than normal with a possible range of color from dark red, somewhat reduced in pigment, to pink, typical of albinism or ocular albinism" [MGI:llw2]
synonym: "reduced eye pigmentation" EXACT []
is_a: MP:0001324 ! abnormal eye pigmentation
is_a: MP:0005408 ! hypopigmentation

[Term]
id: MP:0005174
name: abnormal tail pigmentation
def: "anomaly in the coloration of the tail due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:cwg, MGI:llw2]
synonym: "tail pigmentation abnormalities" EXACT []
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0005175
name: non-pigmented tail tip
def: "lack of color at the end of the tail" [MGI:cwg]
is_a: MP:0005174 ! abnormal tail pigmentation
is_a: MP:0013177 ! abnormal tail tip morphology

[Term]
id: MP:0005176
name: eyelids fail to open
def: "eyes remain shut when eyelids are expected to be open" [MGI:cwg]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "closed eyes" EXACT []
synonym: "eye lids fail to open" EXACT []
synonym: "eyelids don't open" EXACT []
synonym: "eyes fail to open" EXACT []
is_a: MP:0004874 ! abnormal timing of postnatal eyelid opening

[Term]
id: MP:0005178
name: increased circulating cholesterol level
alt_id: MP:0001550
alt_id: MP:0002615
def: "greater than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated total circulating cholesterol level" EXACT []
synonym: "elevated total plasma cholesterol level" NARROW []
synonym: "elevated total serum cholesterol level" NARROW []
synonym: "high serum cholesterol level" NARROW []
synonym: "hypercholesterolaemia" EXACT []
synonym: "hypercholesterolemia" EXACT []
synonym: "increased total circulating cholesterol level" EXACT []
synonym: "increased total plasma cholesterol level" NARROW []
synonym: "increased total serum cholesterol level" NARROW []
is_a: MP:0000180 ! abnormal circulating cholesterol level
is_a: MP:0003982 ! increased cholesterol level

[Term]
id: MP:0005179
name: decreased circulating cholesterol level
alt_id: MP:0002616
def: "less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased total circulating cholesterol level" EXACT []
synonym: "decreased total plasma cholesterol level" NARROW []
synonym: "decreased total serum cholesterol level" NARROW []
synonym: "hypocholesterolaemia" EXACT []
synonym: "hypocholesterolemia" EXACT []
synonym: "low total circulating cholesterol level" EXACT []
synonym: "low total plasma cholesterol level" NARROW []
synonym: "low total serum cholesterol level" NARROW []
synonym: "reduced circulating cholesterol level" EXACT []
is_a: MP:0000180 ! abnormal circulating cholesterol level
is_a: MP:0003983 ! decreased cholesterol level

[Term]
id: MP:0005180
name: abnormal circulating testosterone level
def: "anomaly in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal circulating level of testosterone" EXACT []
is_a: MP:0009819 ! abnormal circulating androgen level
is_a: MP:0011385 ! abnormal testosterone level

[Term]
id: MP:0005181
name: decreased circulating estradiol level
def: "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [ISBN:0-683-40008-8]
synonym: "decreased circulating oestradiol level" EXACT []
synonym: "decreased serum estradiol level" NARROW []
synonym: "decreased serum oestradiol level" NARROW []
synonym: "reduced circulating estradiol level" EXACT []
synonym: "reduced circulating oestradiol level" EXACT []
synonym: "reduced serum estradiol level" NARROW []
synonym: "reduced serum oestradiol level" NARROW []
is_a: MP:0003371 ! decreased circulating estrogen level
is_a: MP:0005183 ! abnormal circulating estradiol level

[Term]
id: MP:0005182
name: increased circulating estradiol level
def: "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [ISBN:0-683-40008-8]
synonym: "elevated serum estradiol level" NARROW []
synonym: "elevated serum oestradiol level" NARROW []
synonym: "increased circulating oestradiol level" EXACT []
synonym: "increased serum estradiol level" NARROW []
synonym: "increased serum oestradiol level" NARROW []
is_a: MP:0003370 ! increased circulating estrogen level
is_a: MP:0005183 ! abnormal circulating estradiol level

[Term]
id: MP:0005183
name: abnormal circulating estradiol level
def: "aberration in the blood concentration of this most potent estrogen" [MGI:cwg]
synonym: "abnormal circulating level of estradiol" EXACT []
synonym: "abnormal circulating level of oestradiol" EXACT []
synonym: "abnormal circulating oestradiol level" EXACT []
is_a: MP:0003369 ! abnormal circulating estrogen level

[Term]
id: MP:0005184
name: abnormal circulating progesterone level
def: "anomaly in the blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [ISBN:0-683-40008-8]
synonym: "abnormal circulating level of progesterone" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0011384 ! abnormal progesterone level

[Term]
id: MP:0005185
name: decreased circulating progesterone level
def: "reduced blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [ISBN:0-683-40008-8]
synonym: "decreased serum progesterone level" NARROW []
synonym: "reduced circulating progesterone level" EXACT []
synonym: "reduced serum progesterone level" NARROW []
is_a: MP:0005184 ! abnormal circulating progesterone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005186
name: increased circulating progesterone level
def: "increased blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [ISBN:0-683-40008-8]
synonym: "elevated serum progesterone level" NARROW []
synonym: "increased serum progesterone level" NARROW []
is_a: MP:0005184 ! abnormal circulating progesterone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005187
name: abnormal penis morphology
def: "any structural anomaly of the organ of copulation and urination in the male" [ISBN:0-683-40008-8]
synonym: "abnormality of the penis" BROAD []
synonym: "penis dysplasia" NARROW []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
is_a: MP:0009199 ! abnormal external male genitalia morphology

[Term]
id: MP:0005188
name: small penis
def: "reduced size of the organ of copulation and urination in the male" [ISBN:0-683-40008-8]
synonym: "decreased penis size" EXACT []
synonym: "micropenis" EXACT []
synonym: "microphallus" NARROW []
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0005189
name: abnormal anogenital distance
def: "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [MGI:cwg]
synonym: "abnormal ano-genital distance" EXACT []
is_a: MP:0003315 ! abnormal perineum morphology

[Term]
id: MP:0005190
name: osteomyelitis
def: "bone inflammation" [ISBN:0-683-40008-8]
is_a: MP:0001533 ! abnormal skeleton physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0005191
name: head tilt
def: "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [MGI:cwg]
is_a: MP:0000436 ! abnormal head movements

[Term]
id: MP:0005192
name: increased motor neuron number
def: "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses" [https://orcid.org/0000-0002-0371-1954]
synonym: "increased motoneuron number" EXACT []
is_a: MP:0000937 ! abnormal motor neuron morphology
is_a: MP:0008947 ! increased neuron number

[Term]
id: MP:0005193
name: abnormal anterior eye segment morphology
alt_id: MP:0000095
def: "any structural anomaly of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)" [ISBN:0-683-40008-8, MESH:A09.371.060]
synonym: "abnormal anterior segment morphology" EXACT []
synonym: "anterior eye segment dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0005194
name: abnormal anterior uvea morphology
def: "any structural anomaly of any of the parts of the front, or ventral, portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris" [ISBN:0-683-40008-8]
synonym: "anterior uvea abnormalities" EXACT []
synonym: "Haller tunica vascula abnormalities" EXACT []
synonym: "tunica vasculosa bulbosa abnormalities" EXACT []
synonym: "uveal tract abnormalities" BROAD []
synonym: "vascular layer of the eyeball" BROAD []
synonym: "vascular tunic of the eye" BROAD []
synonym: "vasculosa oculi abnormalities" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology
is_a: MP:0005197 ! abnormal uvea morphology

[Term]
id: MP:0005195
name: abnormal posterior eye segment morphology
def: "any structural anomaly of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)" [ISBN:0-683-40008-8]
synonym: "posterior eye segment dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0005196
name: obsolete abnormal posterior uvea morphology
def: "any structural anomaly of the rear, or dorsal, portion of the vascular, pigmentary, or middle coat of the eye, includes the choroid" [ISBN:0-683-40008-8]
synonym: "posterior uvea abnormalities" EXACT []
synonym: "tunica vasculosa bulbi" EXACT []
synonym: "tunica vasculosa oculi abnormalities" EXACT []
synonym: "uveal tract abnormalities" BROAD []
synonym: "vascular layer of the eyeball" BROAD []
synonym: "vascular tunic of the eye abnormalities" BROAD []
is_obsolete: true
replaced_by: MP:0005098

[Term]
id: MP:0005197
name: abnormal uvea morphology
def: "any structural anomaly of the pigmented vascular coat of the eyeball, consisting of the iris, ciliary body, and choroid" [MESH:A09.371.894]
synonym: "abnormal tunica vasculosa of eyeball morphology" EXACT []
synonym: "abnormal vascular layer of the eyeball morphology" RELATED []
synonym: "uvea dysplasia" NARROW []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0005198
name: abnormal aqueous drainage system morphology
def: "any structural anomaly of the structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins" [PMID:8652890]
is_a: MP:0005194 ! abnormal anterior uvea morphology

[Term]
id: MP:0005199
name: abnormal iris pigment epithelium
def: "anomaly in the epithelial layer of the iris composed of cells containing pigment granules" [ISBN:0-683-40008-8]
is_a: MP:0001322 ! abnormal iris morphology
is_a: MP:0001324 ! abnormal eye pigmentation

[Term]
id: MP:0005200
name: obsolete abnormal eye pigment epithelium morphology
def: "OBSOLETE. any structural anomaly in the epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules" [MESH:A09.371.670]
comment: This term is not specific to a structure. Best to use the more specific terms of 'abnormal retinal pigment epithelium morphology', 'abnormal ciliary body pigmentation' or 'abnormal iris pigmentation'.
synonym: "abnormal pigment epithelium of the eye" BROAD []
is_obsolete: true

[Term]
id: MP:0005201
name: abnormal retina pigment epithelium morphology
def: "any structural anomaly in the epithelial layer of the retina composed of cells containing pigment granules" [MESH:A09.371.670]
synonym: "abnormal pigmented retinal epithelium morphology" EXACT []
synonym: "abnormal retinal pigment epithelium morphology" EXACT []
synonym: "abnormal RPE morphology" EXACT []
is_a: MP:0001324 ! abnormal eye pigmentation
is_a: MP:0003727 ! abnormal retina layer morphology

[Term]
id: MP:0005202
name: lethargy
def: "mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction" [ISBN:0-683-40008-8]
synonym: "languor" EXACT []
synonym: "listlessness" EXACT []
synonym: "torpidity" EXACT []
synonym: "torpor" EXACT []
is_a: MP:0020224 ! decreased alertness
is_a: MP:0031392 ! hypoactivity

[Term]
id: MP:0005203
name: abnormal trabecular meshwork morphology
def: "any structural anomaly in the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932]
is_a: MP:0004221 ! abnormal iridocorneal angle

[Term]
id: MP:0005204
name: abnormal canal of Schlemm morphology
def: "any structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8]
synonym: "circular sinus abnormalities" EXACT []
synonym: "Fontana canal abnormalities" EXACT []
synonym: "Lauth canal abnormalities" EXACT []
synonym: "Schlemm's canal" EXACT []
synonym: "scleral venous sinus abnormalities" EXACT []
synonym: "sinus circularis abnormalities" EXACT []
synonym: "sinus venosus sclerae abnormalities" EXACT []
synonym: "venous sinus of sclera abnormalities" EXACT []
is_a: MP:0004221 ! abnormal iridocorneal angle

[Term]
id: MP:0005205
name: abnormal eye anterior chamber morphology
def: "any structural anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067]
subset: IMPC
subset: Sanger_Terms
synonym: "eye anterior chamber abnormalities" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0005206
name: abnormal aqueous humor
def: "anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye" [MESH:A09.371.060.067.070]
synonym: "abnormal aqueous flare" EXACT []
synonym: "abnormal aqueous humour" EXACT []
synonym: "abnormal intraocular fluid" EXACT []
synonym: "aqueous humor abnormalities" EXACT []
synonym: "aqueous humour abnormalities" EXACT []
is_a: MP:0005205 ! abnormal eye anterior chamber morphology

[Term]
id: MP:0005207
name: abnormal aqueous vein morphology
def: "any structural anomaly of this vessel that receives aqueous humor from the sinus venosus sclerae (canal of Schlemm)" [ISBN:0-683-40008-8]
is_a: MP:0004221 ! abnormal iridocorneal angle

[Term]
id: MP:0005208
name: abnormal iris stroma morphology
def: "any structural anomaly of the lamellated vascular connective tissue of the iris" [ISBN:0-683-40008-8]
synonym: "abnormal stroma iridis" EXACT []
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0005210
name: disorganized stomach mucosa
def: "derangement of the pattern of the mucous layer of the stomach wall" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised gastric mucosa" EXACT []
is_a: MP:0010792 ! abnormal stomach mucosa morphology

[Term]
id: MP:0005211
name: increased stomach mucosa thickness
def: "greater than the normal depth or width of the of the mucous layer of the stomach wall" [https://orcid.org/0000-0003-3691-0324]
synonym: "expanded mucosal thickness of the stomach" EXACT []
synonym: "increased thickness of gastric mucosa" EXACT []
is_a: MP:0010799 ! stomach mucosa hyperplasia

[Term]
id: MP:0005212
name: obsolete immature goblet-like cells in stomach
def: "OBSOLETE. unusual appearance of stomach mucosa in which one finds cells resembling those that produce and secrete mucins" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005213
name: gastric metaplasia
def: "condition in which there is a change of one adult cell type to another adult cell type in the stomach" [PMID:12080087]
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0005214
name: regional gastric metaplasia
def: "localized areas of the stomach in which there is a change from one adult cell type to another adult cell type" [PMID:12080087]
is_a: MP:0005213 ! gastric metaplasia

[Term]
id: MP:0005215
name: abnormal pancreatic islet morphology
alt_id: MP:0001946
alt_id: MP:0005219
def: "any structural anomaly of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "abnormal islands of Langerhans morphology" EXACT []
synonym: "abnormal islet of Langerhans" EXACT []
synonym: "abnormal islet of Langerhans morphology" EXACT []
synonym: "islet cell abnormalities" EXACT []
is_a: MP:0009165 ! abnormal endocrine pancreas morphology

[Term]
id: MP:0005216
name: abnormal pancreatic alpha cell morphology
def: "any structural anomaly of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
synonym: "abnormal glucagon-secreting cell" EXACT []
synonym: "abnormal pancreatic A cell" EXACT []
synonym: "abnormal pancreatic alpha cells" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0005217
name: abnormal pancreatic beta cell morphology
def: "any structural anomaly of a cell that secretes insulin and is located towards the center of the islets of Langerhans in the pancreas" [CL:0000169]
synonym: "abnormal insulin-secreting cells" EXACT []
synonym: "abnormal pancreatic B cells" EXACT []
synonym: "abnormal pancreatic beta cells" EXACT []
synonym: "abnormal type B enteroendocrine cell morphology" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0005218
name: abnormal pancreatic delta cell morphology
def: "any structural anomaly of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
synonym: "abnormal D cells" EXACT []
synonym: "abnormal pancreatic D cells" BROAD []
synonym: "abnormal pancreatic delta cells" EXACT []
synonym: "abnormal somatostatin-secreting cell morphology" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0005220
name: abnormal exocrine pancreas morphology
def: "any structural anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [MESH:A03.734.540]
synonym: "abnormal exocrine pancreas" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0005221
name: abnormal rostral-caudal axis patterning
alt_id: MP:0001703
def: "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [MGI:cwg]
synonym: "abnormal anterior-posterior axis patterning" NARROW []
synonym: "abnormal head-tail axis patterning" EXACT []
synonym: "abnormal rostro-caudal axis patterning" EXACT []
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0005222
name: abnormal somite size
def: "atypical size of any of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "irregular somite size" EXACT []
is_a: MP:0001688 ! abnormal somite development

[Term]
id: MP:0005223
name: abnormal dorsal-ventral polarity of the somites
def: "anomalous development or formation of the pattern of somites along the axis that runs from the front (ventral) to the back (dorsal) surface of the body" [MGI:cwg, PMID:11641270]
synonym: "abnormal anterior-posterior polarity of the somites" BROAD []
synonym: "abnormal ventro-dorsal polarity of the somites" EXACT []
is_a: MP:0001688 ! abnormal somite development

[Term]
id: MP:0005224
name: abnormal left-right axis symmetry of the somites
def: "anomaly in the formation or development of the somites in relation to the left and right sides of the body" [MGI:cwg]
synonym: "left-right asymmetry" EXACT []
is_a: MP:0001688 ! abnormal somite development
is_a: MP:0001706 ! abnormal left-right axis patterning

[Term]
id: MP:0005225
name: abnormal vertebrae development
def: "anomalous formation of the vertebrae from the sclerotome" [MGI:cwg]
is_a: MP:0000137 ! abnormal vertebrae morphology
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0005226
name: abnormal vertebral arch development
def: "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen" [ISBN:0-683-40008-8]
synonym: "abnormal dorsal arch development" EXACT []
synonym: "abnormal neural arch development" EXACT []
is_a: MP:0004599 ! abnormal vertebral arch morphology
is_a: MP:0005225 ! abnormal vertebrae development

[Term]
id: MP:0005227
name: abnormal vertebral body development
def: "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [ISBN:0-683-40008-8]
is_a: MP:0000141 ! abnormal vertebral body morphology
is_a: MP:0005225 ! abnormal vertebrae development

[Term]
id: MP:0005228
name: obsolete abnormal fusion of vertebral bodies/neural arches
def: "OBSOLETE. improper joining of the main portion of the vertebra anterior to the vertebral canal and the cartilaginous or bony arch that encloses and protects the spinal cord on the back" [ISBN:0-683-40008-8]
synonym: "vertebral body/neural arch fusion" EXACT []
is_obsolete: true

[Term]
id: MP:0005229
name: abnormal intervertebral disk development
def: "any anomaly in the formation of the cartilaginous and gelatinous structure found between vertebrae" [MGI:cwg]
synonym: "abnormal intervertebral disc development" EXACT []
synonym: "abnormal intervertebral disc formation" EXACT []
synonym: "abnormal intervertebral disk formation" EXACT []
is_a: MP:0000164 ! abnormal cartilage development
is_a: MP:0004173 ! abnormal intervertebral disk morphology
is_a: MP:0005225 ! abnormal vertebrae development

[Term]
id: MP:0005230
name: ectrodactyly
def: "absence of the middle rays, i.e., the central digits; usually associated with cleft hands/feet and may also include syndactyly or aplasia of remaining digits" [MIM:119100]
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0005231
name: abnormal brachial lymph node morphology
def: "any structural anomaly of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8]
synonym: "brachial lymph node abnormalities" EXACT []
synonym: "humeral axillary lymph node abnormalities" EXACT []
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0005232
name: abnormal mesenteric lymph node morphology
def: "any structural anomaly of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8]
synonym: "mesenteric lymph node abnormalities" EXACT []
is_a: MP:0009625 ! abnormal abdominal lymph node morphology

[Term]
id: MP:0005235
name: obsolete abnormal olfactory pathway morphology
def: "OBSOLETE. any structural anomaly of any of the set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex, including the olfactory nerve; olfactory bulb; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex" [MESH:A08.186.211.464.699]
synonym: "abnormal olfactory pathways" EXACT []
is_obsolete: true

[Term]
id: MP:0005236
name: abnormal olfactory nerve morphology
alt_id: MP:0001057
def: "any structural anomaly of the first cranial nerve, which conveys the sense of smell" [MESH:A08.800.800.120.640]
synonym: "abnormal CN-I morphology" EXACT []
synonym: "olfactory nerve abnormalities" BROAD []
synonym: "olfactory nerve dysplasia" NARROW []
is_a: MP:0001056 ! abnormal cranial nerve morphology

[Term]
id: MP:0005237
name: abnormal olfactory tract morphology
def: "any structural anomaly of the nerve-like, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus" [ISBN:0-683-40008-8]
synonym: "abnormal olfactory tract" EXACT []
xref: MA:0000975
is_a: MP:0005267 ! abnormal olfactory cortex morphology

[Term]
id: MP:0005238
name: increased brain size
alt_id: MP:0000773
def: "larger than the normal physical proportions of the brain" [MGI:cwg]
synonym: "enlarged brain" EXACT []
synonym: "larger brain size" EXACT []
synonym: "macrencephaly" EXACT []
synonym: "macroencephaly" EXACT []
synonym: "megalencephaly" EXACT []
synonym: "megaloencephaly" EXACT []
is_a: MP:0000771 ! abnormal brain size

[Term]
id: MP:0005239
name: abnormal Bruch membrane morphology
def: "any structural anomaly of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [ISBN:0-683-40008-8]
synonym: "basal lamina of the choroid abnormalities" EXACT []
synonym: "basal layer of the choroid abnormalities" EXACT []
synonym: "Bruch's membrane abnormalities" EXACT []
synonym: "Henle membrane abnormalities" EXACT []
synonym: "lamina basalis choroidae abnormalities" EXACT []
synonym: "lamina vitrea abnormalities" EXACT []
synonym: "vitreous lamella abnormalities" EXACT []
is_a: MP:0005098 ! abnormal optic choroid morphology

[Term]
id: MP:0005240
name: abnormal amacrine cell morphology
def: "any structural anomaly of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [MESH:A08.663.358.050]
synonym: "abnormal amacrine cells" BROAD []
synonym: "abnormal amacrine neuron morphology" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0005241
name: abnormal retina ganglion layer morphology
def: "any structural anomaly of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [ISBN:0-914294-08-3]
synonym: "abnormal retina GCL morphology" EXACT []
synonym: "abnormal retinal ganglion cell layer" EXACT []
synonym: "abnormal retinal ganglion layer morphology" EXACT []
synonym: "abnormal retinal GCL morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0005242
name: cryptophthalmos
def: "congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids" [ISBN:0-683-40008-8]
is_a: MP:0001341 ! absent eyelids

[Term]
id: MP:0005243
name: hemothorax
def: "bleeding into the pleural space" [ISBN:0-397-51047-0]
synonym: "haematothorax" EXACT []
synonym: "haemothorax" EXACT []
synonym: "hematothorax" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0002295 ! abnormal pulmonary circulation

[Term]
id: MP:0005244
name: hemopericardium
alt_id: MP:0000289
def: "bleeding into the pericardial space" [ISBN:0-397-51047-0]
synonym: "blood in pericardial cavity" EXACT []
synonym: "haemopericardium" EXACT []
synonym: "haemorrhagic pericardial effusion" EXACT []
synonym: "hemorrhagic pericardial effusion" EXACT []
synonym: "pericardial haemorrhage" EXACT []
synonym: "pericardial hemorrhage" EXACT []
is_a: MP:0005312 ! pericardial effusion
is_a: MP:0009698 ! heart hemorrhage
is_a: MP:0012501 ! abnormal pericardial cavity morphology

[Term]
id: MP:0005245
name: hemarthrosis
def: "bleeding into a joint space" [ISBN:0-397-51047-0]
synonym: "haemarthrosis" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0031169 ! abnormal joint physiology

[Term]
id: MP:0005247
name: abnormal extraocular muscle morphology
def: "any structural anomaly of any of the striated muscles that are located within the orbit but are extrinsic and separate from the eyeball itself and control the movements of the eyeball and the superior eyelid; there are seven extraocular muscles: superior rectus, inferior rectus, medial rectus, lateral rectus, inferior oblique, superior oblique, and levator palpebrae superioris" [MGI:cwg]
synonym: "abnormal extra-ocular muscle morphology" EXACT []
xref: http://teachmeanatomy.info/head/organs/eye/extraocular-muscles/
xref: https://en.wikipedia.org/wiki/Extraocular_muscles
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0003686 ! abnormal eye muscle morphology

[Term]
id: MP:0005248
name: abnormal Harderian gland morphology
def: "any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane" [ISBN:0486631850, PMID:8843648]
comment: The Harderian gland does not normally exist in some types of mammals (bats, cows and horses), terrestrial carnivores, and higher primates including human.
synonym: "Harderian gland abnormalities" BROAD []
synonym: "Harderian gland dysplasia" NARROW []
is_a: MP:0013544 ! abnormal merocrine gland morphology

[Term]
id: MP:0005249
name: abnormal palatine bone morphology
def: "any structural anomaly of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits" [ISBN:0-683-40008-8]
synonym: "abnormal palatinium bone" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0005250
name: decreased Sertoli cell number
def: "decreased number of the supporting cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [ISBN:0-683-40008-8]
synonym: "decreased sertoli cell number" EXACT []
synonym: "reduced Sertoli cell number" EXACT []
synonym: "reduced sertoli cell number" EXACT []
synonym: "Sertoli cell hypoplasia" NARROW []
is_a: MP:0002784 ! abnormal Sertoli cell morphology

[Term]
id: MP:0005251
name: blepharitis
def: "inflammation of the eyelids" [MESH:C11.338.133]
synonym: "eye lid inflammation" EXACT []
synonym: "inflamed eyelids" EXACT []
synonym: "palpebritis" EXACT []
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0005252
name: abnormal Meibomian gland morphology
def: "any structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [ISBN:0-683-40008-8]
synonym: "abnormal tarsal gland" RELATED []
synonym: "meibomian gland dysplasia" NARROW []
is_a: MP:0001340 ! abnormal eyelid morphology
is_a: MP:0009535 ! abnormal skin sebaceous gland morphology

[Term]
id: MP:0005253
name: abnormal eye physiology
def: "any functional anomaly and/or activity of the spheroid organ and optic nerve that serves to detect light" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0005391 ! vision/eye phenotype

[Term]
id: MP:0005254
name: strabismus
def: "misalignment of the visual axes of the eyes" [MESH:C10.292.562.887]
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0005255
name: exotropia
def: "a form of ocular misalignment in which the lateral rectus muscle pulls the eye in an outward direction" [MESH:C10.292.562.887.650]
is_a: MP:0005254 ! strabismus

[Term]
id: MP:0005256
name: esotropia
def: "a form of ocular misalignment in which there is excessive convergence of the visual axes, giving a cross-eyed appearance" [MESH:C11.590.810.400]
synonym: "cross eyed" EXACT []
is_a: MP:0005254 ! strabismus

[Term]
id: MP:0005257
name: abnormal intraocular pressure
def: "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [ISBN:0-683-40008-8]
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0005258
name: ocular hypertension
alt_id: MP:0005259
def: "abnormal elevation of the intraocular pressure" [MESH:C11.525]
is_a: MP:0005257 ! abnormal intraocular pressure

[Term]
id: MP:0005260
name: ocular hypotension
def: "abnormally low intraocular pressure" [MESH:C11.540]
is_a: MP:0005257 ! abnormal intraocular pressure

[Term]
id: MP:0005261
name: aniridia
def: "abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth" [MESH:C11.250.060]
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0005262
name: coloboma
def: "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MESH:C11.250.110]
subset: CvDC_Terms
xref: Fyler:4311
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0005263
name: obsolete ectopia lentis
def: "OBSOLETE. congenital displacement of the lens due to defective zonule formation" [MESH:C11.250.300]
synonym: "ectopic lens" EXACT []
synonym: "lens displacement" EXACT []
is_obsolete: true
replaced_by: MP:0031428

[Term]
id: MP:0005264
name: glomerulosclerosis
def: "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [ISBN:0-683-40008-8]
synonym: "glomerular sclerosis" EXACT []
is_a: MP:0000523 ! cortical renal glomerulopathies

[Term]
id: MP:0005265
name: abnormal blood urea nitrogen level
def: "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [ISBN:0-683-40008-8]
synonym: "abnormal blood urea nitrogen" EXACT []
synonym: "abnormal BUN" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0005266
name: abnormal metabolism
def: "any anomaly in the processes that cause many of the chemical changes in living organisms, including anabolism and catabolism; metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation" [GO:0008152]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal metabolic process" EXACT []
synonym: "metabolic abnormalities" EXACT []
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0005267
name: abnormal olfactory cortex morphology
def: "any structural anomaly of cortex area which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [ISBN:0-683-40008-8]
synonym: "olfactory cortex dysplasia" NARROW []
xref: MA:0000193
is_a: MP:0009944 ! abnormal olfactory lobe morphology

[Term]
id: MP:0005269
name: abnormal occipital bone morphology
def: "any structural anomaly of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8]
comment: The basioccipital, exoccipital and supraoccipital bones are distinct bones in prenatal, neonatal and some early juvenile stages in most mammals. In adult organisms, these structures are fused to form the unified adult occipital bone.  This term refers to the adult mammalian structure.
synonym: "occipital bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0005270
name: abnormal zygomatic bone morphology
def: "any structural anomaly of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cheek bone morphology" EXACT []
synonym: "abnormal jugal bone morphology" EXACT []
synonym: "abnormal malar bone morphology" EXACT []
synonym: "abnormal yoke bone morphology" EXACT []
synonym: "zygomatic bone dysplasia" NARROW []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0005271
name: abnormal lacrimal bone morphology
def: "any structural anomaly of the irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla" [ISBN:0-683-40008-8]
synonym: "lacrimal bone dysplasia" NARROW []
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0005272
name: abnormal temporal bone morphology
def: "any structural anomaly of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [ISBN:0-683-40008-8]
synonym: "abnormal squamosal bone morphology" BROAD []
synonym: "temporal bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology

[Term]
id: MP:0005274
name: abnormal viscerocranium morphology
def: "any structural anomaly of the part of the skull that comprises the facial bones" [ISBN:0-683-40008-8]
synonym: "abnormal facial bones morphology" EXACT []
synonym: "viscerocranium dysplasia" NARROW []
is_a: MP:0000438 ! abnormal cranium morphology

[Term]
id: MP:0005275
name: abnormal skin tensile strength
def: "change from the normal maximum tension the skin can withstand without tearing" [ISBN:0-683-40008-8]
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0005277
name: abnormal brainstem morphology
def: "any structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal brain stem morphology" EXACT []
synonym: "abnormal truncus encephali morphology" EXACT []
synonym: "brainstem dysplasia" NARROW []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0005278
name: abnormal cholesterol homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of cholesterol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [GO:0042632, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0005279
name: narcolepsy
def: "recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by cataplexy, sleep paralysis and hallucinations" [ISBN:0-683-40008-8]
is_a: MP:0001501 ! abnormal sleep pattern

[Term]
id: MP:0005280
name: abnormal fatty acids level
def: "any anomaly in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated" [CHEBI:24024]
synonym: "abnormal fatty acid level" EXACT []
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0005281
name: increased fatty acids level
def: "elevated concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated" [CHEBI:24024]
synonym: "elevated fatty acid level" EXACT []
synonym: "increased fatty acid level" EXACT []
is_a: MP:0005280 ! abnormal fatty acids level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0005282
name: decreased fatty acids level
def: "reduction in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated" [CHEBI:24024]
synonym: "decreased fatty acid level" EXACT []
synonym: "lowered fatty acid level" EXACT []
synonym: "reduced fatty acid level" EXACT []
is_a: MP:0005280 ! abnormal fatty acids level
is_a: MP:0014461 ! decreased lipid level

[Term]
id: MP:0005283
name: increased unsaturated fatty acids level
def: "elevated concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms" [CHEBI:24024, ISBN:0-683-40008-8]
synonym: "elevated unsaturated fatty acid level" EXACT []
synonym: "increased unsaturated fatty acid level" EXACT []
is_a: MP:0005281 ! increased fatty acids level

[Term]
id: MP:0005284
name: increased saturated fatty acids level
def: "elevated concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms" [CHEBI:24024, ISBN:0-683-40008-8]
synonym: "elevated saturated fatty acid level" EXACT []
synonym: "increased saturated fatty acid level" EXACT []
is_a: MP:0005281 ! increased fatty acids level

[Term]
id: MP:0005285
name: decreased unsaturated fatty acids level
def: "reduced concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms" [CHEBI:24024, ISBN:0-683-40008-8]
synonym: "decreased unsaturated fatty acid level" EXACT []
synonym: "lowered unsaturated fatty acid level" EXACT []
synonym: "reduced unsaturated fatty acid level" EXACT []
is_a: MP:0005282 ! decreased fatty acids level

[Term]
id: MP:0005286
name: decreased saturated fatty acids level
def: "reduced concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms" [CHEBI:24024, ISBN:0-683-40008-8]
synonym: "decreased saturated fatty acid level" EXACT []
synonym: "lowered saturated fatty acid level" EXACT []
synonym: "reduced saturated fatty acid level" EXACT []
is_a: MP:0005282 ! decreased fatty acids level

[Term]
id: MP:0005287
name: narrow eye opening
def: "less than the normal distance from one eyelid to the other without fusion of the eyelid margins" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "blepharophimosis" NARROW [https://eyewiki.org/Blepharophimosis_Syndrome]
synonym: "blepharostenosis" EXACT []
synonym: "closer eyelid folds" EXACT []
synonym: "closer roots of eyelids" EXACT []
synonym: "narrow palpebral fissure" EXACT []
synonym: "reduced palpebral fissure size" EXACT []
synonym: "slit eyes" EXACT []
synonym: "small eyelid aperture" EXACT []
is_a: MP:0003671 ! abnormal eyelid aperture

[Term]
id: MP:0005288
name: abnormal oxygen consumption
def: "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MESH:G06.535.723]
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0005289
name: increased oxygen consumption
def: "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MESH:G06.535.723]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0005288 ! abnormal oxygen consumption

[Term]
id: MP:0005290
name: decreased oxygen consumption
def: "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MESH:G06.535.723]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced oxygen consumption" EXACT []
is_a: MP:0005288 ! abnormal oxygen consumption

[Term]
id: MP:0005291
name: abnormal glucose tolerance
def: "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MESH:C18.452.394.952.500]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0005292
name: improved glucose tolerance
def: "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MESH:C18.452.394.952.500]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased glucose clearance" RELATED []
synonym: "increased glucose tolerance" EXACT []
is_a: MP:0005291 ! abnormal glucose tolerance

[Term]
id: MP:0005293
name: impaired glucose tolerance
def: "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MESH:C18.452.394.952.500]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "glucose intolerance" BROAD []
synonym: "poor glucose tolerance" EXACT []
synonym: "reduced glucose tolerance" EXACT []
is_a: MP:0005291 ! abnormal glucose tolerance

[Term]
id: MP:0005294
name: abnormal heart ventricle morphology
def: "any structural anomaly of one or both of the two lower chambers of the heart" [MESH:A07.541.560, MGI:cwg]
synonym: "heart ventricle dysplasia" NARROW []
synonym: "ventricular dysplasia" BROAD []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0005296
name: abnormal humerus morphology
def: "any structural anomaly of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "humerus dysplasia" NARROW []
is_a: MP:0003854 ! abnormal forelimb stylopod morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0005297
name: spina bifida occulta
def: "defective closure of the laminae of the vertebral column in the lumbosacral region without hernial protrusion of the spinal cord or meninges; the mildest, most common and often asymptomatic form of spina bifida, identified externally by a skin depression or dimple, dark tufts of hair, telangiectasis, or soft subcutaneous lipomas at the site of defect" [https://orcid.org/0000-0002-6490-7723]
synonym: "closed spinal bifida" EXACT []
synonym: "cryptomerorrhachischis" EXACT []
synonym: "hidden spina bifida" EXACT []
synonym: "occult spina bifida" EXACT []
is_a: MP:0003054 ! spina bifida
is_a: MP:0005226 ! abnormal vertebral arch development

[Term]
id: MP:0005298
name: abnormal clavicle morphology
def: "any structural anomaly of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal collar bone morphology" EXACT []
synonym: "clavicle dysplasia" NARROW []
is_a: MP:0003723 ! abnormal long bone morphology
is_a: MP:0004508 ! abnormal pectoral girdle bone morphology

[Term]
id: MP:0005299
name: abnormal eye posterior chamber morphology
def: "any structural anomaly of the ring-like space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [ISBN:0-683-40008-8]
synonym: "eye posterior chamber abnormalities" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0005300
name: abnormal cornea stroma morphology
def: "any structural anomaly of the lamellated connective tissue of the cornea between the Bowman and Descemet membranes" [ISBN:0-683-40008-8, MESH:A09.371.060.217.228]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal corneal stroma morphology" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0005301
name: abnormal cornea endothelium morphology
def: "any structural anomaly of the single layer of large flattened cells that cover the surface of the cornea" [MESH:A09.371.060.067.318]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal corneal endothelium morphology" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0005302
name: neurogenic bladder
def: "defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS" [ISBN:0-683-40008-8]
synonym: "neuropathic bladder" EXACT []
is_a: MP:0002184 ! abnormal innervation
is_a: MP:0010386 ! abnormal urinary bladder physiology

[Term]
id: MP:0005304
name: bulbourethral gland cyst
def: "presence of one or more membrane-lined sacs containing gas, fluid, or semisolid matter in the bulbourethral gland" [ISBN:0-683-40008-8]
synonym: "bulbourethral gland cysts" EXACT []
synonym: "Cowper gland cyst" EXACT []
synonym: "Cowper gland cysts" EXACT []
synonym: "cystic bulbo-urethral gland" EXACT []
synonym: "cystic bulbourethral gland" EXACT []
synonym: "cystic Cowper's gland" EXACT []
synonym: "cystic Mery gland" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0005305
name: prostate gland anterior lobe hyperplasia
def: "increase in the number of normal cells in normal arrangement in the prostate gland anterior lobe, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "anterior prostate hyperplasia" EXACT []
synonym: "AP hyperplasia" EXACT []
synonym: "CG hyperplasia" EXACT []
synonym: "coagulating gland hyperplasia" EXACT []
synonym: "hyperplastic anterior prostate lobe" EXACT []
synonym: "hyperplastic coagulating gland" EXACT []
synonym: "hyperplastic prostate gland anterior lobe" EXACT []
is_a: MP:0009738 ! enlarged prostate gland anterior lobe

[Term]
id: MP:0005306
name: abnormal phalanx morphology
def: "any structural anomaly of any of the long bones of the digits" [ISBN:0-683-40008-8]
synonym: "abnormal phalanges morphology" EXACT []
synonym: "abnormal phalanxes morphology" EXACT []
synonym: "phalanges dysplasia" NARROW []
is_a: MP:0002110 ! abnormal digit morphology
is_a: MP:0011504 ! abnormal limb long bone morphology

[Term]
id: MP:0005307
name: head tossing
def: "repetitive flailing of the head in multiple directions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000436 ! abnormal head movements
is_a: MP:0001408 ! stereotypic behavior

[Term]
id: MP:0005308
name: abnormal circulating ammonia level
def: "aberrant amount of ammonia or its compounds in blood, formed in the body during organic decomposition" [ISBN:0-683-40008-8]
synonym: "abnormal blood ammonia level" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis
is_a: MP:0030604 ! abnormal ammonia homeostasis

[Term]
id: MP:0005309
name: increased circulating ammonia level
def: "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy" [ISBN:0-683-40008-8]
synonym: "hyperammonaemia" EXACT []
synonym: "hyperammonemia" EXACT []
synonym: "increased ammonia concentration" RELATED []
synonym: "increased blood ammonia level" EXACT []
is_a: MP:0005308 ! abnormal circulating ammonia level

[Term]
id: MP:0005310
name: abnormal salivary gland physiology
def: "any functional anomaly of any of the glands in the mouth that secrete saliva" [MESH:A03.556.500.760]
synonym: "abnormal salivary gland function" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0013557 ! abnormal merocrine gland physiology

[Term]
id: MP:0005311
name: abnormal circulating amino acid level
def: "any anomaly in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709]
synonym: "abnormal blood amino acid level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0005312
name: pericardial effusion
def: "escape of fluid from blood vessels or lymphatic vessels into the fibrous sac surrounding the heart" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "dropsy of pericardium" EXACT []
xref: Fyler:1940
is_a: MP:0000288 ! abnormal pericardium morphology
is_a: MP:0021205 ! effusion

[Term]
id: MP:0005313
name: absent adrenal gland
def: "absence of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [ISBN:0-683-40008-8]
synonym: "absence of adrenal glands" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0005314
name: absent thyroid gland
def: "lack of the endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [ISBN:0-683-40008-8]
synonym: "absence of thyroid gland" EXACT []
is_a: MP:0004663 ! athyroidism

[Term]
id: MP:0005315
name: absent pituitary gland
def: "lack of the gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [ISBN:0-683-40008-8]
synonym: "absence of pituitary gland" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology

[Term]
id: MP:0005316
name: abnormal response to tactile stimuli
def: "anomaly in the reflex action normally induced by touch or pain" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal tactile reflex" EXACT []
is_a: MP:0001968 ! abnormal touch/ nociception
is_a: MP:0012079 ! abnormal spinal reflex

[Term]
id: MP:0005317
name: increased triglyceride level
def: "greater concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "elevated triglyceride level" EXACT []
is_a: MP:0000187 ! abnormal triglyceride level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0005318
name: decreased triglyceride level
def: "reduced concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "low triglyceride level" EXACT []
synonym: "reduced triglyceride level" EXACT []
is_a: MP:0000187 ! abnormal triglyceride level
is_a: MP:0014461 ! decreased lipid level

[Term]
id: MP:0005319
name: abnormal enzyme/coenzyme level
def: "altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances" [ISBN:0-683-40008-8]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0005320
name: abnormal biopterin level
def: "anomaly in the concentration of this pterin found in yeast, the fruit fly and in normal human urine, the reduced form of which acts as a coenzyme for many enzymatic reactions" [ISBN:0-683-40008-8, MESH:D03.438.733.631.202]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0005321
name: abnormal neopterin level
def: "anomaly in the concentration of a pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection" [ISBN:0-683-40008-8, MESH:D03.438.733.631.202.500]
is_a: MP:0005320 ! abnormal biopterin level

[Term]
id: MP:0005322
name: abnormal serotonin level
def: "anomaly in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8, MESH:D02.092.211.215.801.852]
synonym: "abnormal 5-HT level" EXACT []
synonym: "abnormal 5-hydroxytryptamine level" EXACT []
synonym: "abnormal enteramine level" EXACT []
synonym: "abnormal hippophaine level" EXACT []
synonym: "abnormal hydroxytryptamine level" EXACT []
synonym: "abnormal serotonin concentration" RELATED []
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0005323
name: dystonia
def: "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
is_a: MP:0003492 ! abnormal involuntary movement
is_a: MP:0004142 ! abnormal muscle tone

[Term]
id: MP:0005324
name: ascites
def: "accumulation or retention of fluid within the peritoneal cavity" [https://www.asbestos.com/mesothelioma/peritoneal-effusion/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152461/, ISBN:0-683-40008-8]
synonym: "abdominal effusion" EXACT []
synonym: "peritoneal effusion" EXACT [https://mesothelioma.net/peritoneal-effusion-ascites/]
is_a: MP:0021205 ! effusion

[Term]
id: MP:0005325
name: abnormal renal glomerulus morphology
def: "any structural anomaly of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit" [ISBN:0-683-40008-8]
synonym: "abnormal glomerular tuft morphology" EXACT []
synonym: "abnormal glomeruli morphology" EXACT []
synonym: "abnormal kidney glomerulus morphology" EXACT []
synonym: "abnormal malpighian glomerulus morphology" EXACT []
synonym: "abnormal malpighian tuft morphology" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology

[Term]
id: MP:0005326
name: abnormal podocyte morphology
def: "any structural anomaly of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal glomerular epithelial cells" EXACT []
synonym: "abnormal podocytes" EXACT []
synonym: "abnormal visceral epithelial cell" EXACT []
is_a: MP:0011497 ! abnormal glomerular capsule visceral layer morphology

[Term]
id: MP:0005327
name: abnormal mesangial cell morphology
def: "any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal deep cell" EXACT []
synonym: "abnormal intercapillary cell" EXACT []
synonym: "abnormal intraglomerular mesangial cell" EXACT []
is_a: MP:0000358 ! abnormal cell morphology
is_a: MP:0011339 ! abnormal glomerular mesangium morphology

[Term]
id: MP:0005328
name: abnormal circulating creatinine level
def: "anomaly in the blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [ISBN:0-683-40008-8]
synonym: "abnormal blood creatinine level" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level

[Term]
id: MP:0005329
name: abnormal myocardium layer morphology
def: "any structural anomaly of the middle layer of the heart, comprised mainly of striated cardiac muscle fibers" [ISBN:0-683-40008-8]
comment: Do not confuse cardiac muscle tissue with the myocardium. Myocardium consists primarily of cardiac muscle but these structures are not identical.
subset: CvDC_Terms
synonym: "abnormal myocardium morphology" EXACT []
synonym: "myocardial dysplasia" NARROW []
is_a: MP:0010545 ! abnormal heart layer morphology
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology

[Term]
id: MP:0005330
name: cardiomyopathy
def: "diseases of the heart (myocardium); may result from many causes" [https://orcid.org/0000-0002-0371-1954, MESH:C14.280.238, MGI:cwg]
subset: CvDC_Terms
xref: Fyler:1840
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0005331
name: insulin resistance
def: "diminished effectiveness of insulin in lowering plasma glucose levels" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0005332
name: abnormal amino acid level
def: "any anomaly in the amount of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0005333
name: decreased heart rate
def: "fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute" [https://orcid.org/0000-0002-0371-1954]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "bradycardia" EXACT []
synonym: "bradyrhythmia" EXACT []
synonym: "reduced heart rate" EXACT []
is_a: MP:0001629 ! abnormal heart rate

[Term]
id: MP:0005334
name: abnormal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue" [MGI:cwg]
synonym: "abnormal fat body morphology" EXACT []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0005335
name: abnormal gonadal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:cwg]
synonym: "abnormal epigonadal fat pad morphology" NARROW [PMID:33148396, PMID:34390703]
synonym: "abnormal gonadal fat depot morphology" EXACT []
synonym: "abnormal perigonadal fat pad morphology" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0005336
name: abnormal inguinal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue found in the groin" [MGI:cwg]
synonym: "abnormal inguinal fat depot morphology" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0005337
name: abnormal retroperitoneal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue found on the dorsal side of the peritoneum" [MGI:cwg]
synonym: "abnormal retroperitoneal fat depot morphology" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0005338
name: atherosclerotic lesions
def: "thickening and loss of elasticity of arterial walls, involving plaque-like lipid deposition and thickening of intimal layers within arteries; progresses to narrowing of arterial lumens with fibrosis and calcification resulting in restriction of blood flow" [ISBN:0-683-40008-8, MESH:C14.907.137.126.307]
synonym: "atherosclerosis" EXACT []
is_a: MP:0003991 ! arteriosclerosis

[Term]
id: MP:0005339
name: increased susceptibility to atherosclerosis
def: "more likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MGI:cwg]
synonym: "decreased resistance to atherosclerosis" EXACT []
is_a: MP:0005338 ! atherosclerotic lesions
is_a: MP:0005340 ! abnormal susceptibility to atherosclerosis

[Term]
id: MP:0005340
name: abnormal susceptibility to atherosclerosis
def: "a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MGI:cwg]
synonym: "abnormal resistance to atherosclerosis" EXACT []
synonym: "altered susceptibility to atherosclerosis" EXACT []
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0005341
name: decreased susceptibility to atherosclerosis
alt_id: MP:0002701
def: "less likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MGI:cwg]
synonym: "increased resistance to atherosclerosis" EXACT []
synonym: "reduced susceptibility to atherosclerosis" EXACT []
is_a: MP:0005340 ! abnormal susceptibility to atherosclerosis

[Term]
id: MP:0005342
name: abnormal intestinal lipid absorption
def: "any anomaly in the ability of the body to take up lipids into the blood by absorption from the small intestine" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lipid absorption" RELATED []
is_a: MP:0001666 ! abnormal intestinal absorption
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0005343
name: increased circulating aspartate transaminase level
def: "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated aspartate transaminase level" BROAD []
synonym: "elevated AST level" BROAD []
synonym: "elevated circulating AAT level" EXACT []
synonym: "elevated circulating ASAT level" EXACT []
synonym: "elevated circulating aspartate transaminase level" EXACT []
synonym: "elevated circulating serum glutamic oxaloacetic transaminase level" EXACT []
synonym: "elevated circulating SGOT level" EXACT []
synonym: "increased AST level" BROAD []
synonym: "increased circulating AAT level" EXACT []
synonym: "increased circulating ASAT level" EXACT []
synonym: "increased circulating aspartate aminotransferase level" EXACT []
synonym: "increased circulating serum glutamic oxaloacetic transaminase level" EXACT []
synonym: "increased circulating SGOT level" EXACT []
is_a: MP:0000203 ! abnormal circulating aspartate transaminase level
is_a: MP:0014450 ! increased circulating enzyme level

[Term]
id: MP:0005344
name: increased circulating bilirubin level
def: "increased concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "elevated bilirubin level" BROAD []
synonym: "elevated circulating bilirubin level" EXACT []
synonym: "hyperbilirubinaemia" EXACT []
synonym: "hyperbilirubinemia" EXACT []
is_a: MP:0001569 ! abnormal circulating bilirubin level

[Term]
id: MP:0005345
name: abnormal circulating corticosterone level
def: "anomaly in the amount of the adrenocortical steroid in the blood that induces glycogen deposition and regulates sodium conservation and potassium secretion" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal serum level of corticosterone" NARROW []
is_a: MP:0003366 ! abnormal circulating glucocorticoid level
is_a: MP:0003963 ! abnormal corticosterone level

[Term]
id: MP:0005346
name: abnormal circulating aldosterone level
def: "anomaly in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [ISBN:0-683-40008-8]
synonym: "abnormal serum level of aldosterone" NARROW []
is_a: MP:0003372 ! abnormal circulating mineralocorticoid level
is_a: MP:0011415 ! abnormal aldosterone level

[Term]
id: MP:0005348
name: increased T cell proliferation
def: "increase in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "enhanced T cell proliferation" EXACT []
synonym: "enhanced T-cell proliferation" EXACT []
synonym: "increased T-cell proliferation" EXACT []
synonym: "T cell hyperproliferation" EXACT []
synonym: "T-cell hyperproliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0005094 ! abnormal T cell proliferation

[Term]
id: MP:0005349
name: obsolete abnormal interleukin-6 physiology
def: "OBSOLETE. functional anomaly of this soluble factor produced by B- and T-cells, with effects on T- and B-cell growth and differentiation, and in acute phase reactions" [ISBN:0-8153-1691-7]
comment: This term is obsolete.  Instead, use the terms abnormal circulating interleukin-6 level (MP:0008595) and its children or abnormal interleukin-6 secretion (MP:0008704) and its children.
synonym: "abnormal IL-6 physiology" EXACT []
is_obsolete: true
consider: MP:0008595
consider: MP:0008704

[Term]
id: MP:0005350
name: increased susceptibility to autoimmune disorder
def: "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MESH:C20.111, MGI:cwg]
synonym: "decreased resistance to autoimmune disorder" EXACT []
is_a: MP:0002425 ! abnormal susceptibility to autoimmune disorder

[Term]
id: MP:0005351
name: decreased susceptibility to autoimmune disorder
def: "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MESH:C20.111, MGI:cwg]
synonym: "increased resistance to autoimmune disorder" EXACT []
synonym: "reduced susceptibility to autoimmune disorder" EXACT []
is_a: MP:0002425 ! abnormal susceptibility to autoimmune disorder

[Term]
id: MP:0005352
name: small cranium
def: "reduced size of the cranium" [MGI:cwg]
synonym: "decreased cranium size" EXACT []
synonym: "decreased skull size" BROAD []
synonym: "reduced cranium size" EXACT []
synonym: "reduced skull size" BROAD []
is_a: MP:0010031 ! abnormal cranium size

[Term]
id: MP:0005353
name: abnormal patella morphology
def: "any structural anomaly of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal kneecap morphology" BROAD []
synonym: "patella dysplasia" NARROW []
is_a: MP:0002115 ! abnormal limb bone morphology
is_a: MP:0030881 ! abnormal knee morphology

[Term]
id: MP:0005354
name: abnormal ilium morphology
def: "any structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal iliac bone morphology" EXACT []
synonym: "ilium dysplasia" NARROW []
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology

[Term]
id: MP:0005355
name: enlarged thyroid gland
def: "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "goiter" NARROW []
synonym: "increased thyroid gland size" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0005356
name: positive geotaxis
def: "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [https://orcid.org/0000-0003-3691-0324, PMID:12370287]
synonym: "absent negative geotaxis" EXACT []
synonym: "poor negative geotaxis" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior

[Term]
id: MP:0005357
name: novel environmental response-related retropulsion
def: "when confronted with a novel stimulus, subjects exhibit involuntary backward walking" [https://orcid.org/0000-0003-3691-0324, PMID:12370287]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001413 ! abnormal response to new environment
is_a: MP:0010323 ! retropulsion

[Term]
id: MP:0005358
name: abnormal incisor morphology
def: "any structural anomaly of the long teeth, normally consisting of two pairs, top and bottom, that are the most anterior and prominent in the jaw" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal incisors morphology" EXACT []
synonym: "incisor dysplasia" NARROW []
is_a: MP:0002100 ! abnormal tooth morphology

[Term]
id: MP:0005359
name: growth retardation of incisors
def: "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw" [https://orcid.org/0000-0002-0371-1954]
is_a: MP:0000116 ! abnormal tooth development

[Term]
id: MP:0005360
name: urolithiasis
def: "presence of calculi in any part of the urinary system" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000516 ! abnormal renal/urinary system morphology

[Term]
id: MP:0005361
name: small pituitary gland
def: "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus" [MGI:cwg]
synonym: "decreased pituitary gland size" EXACT []
synonym: "reduced pituitary gland size" EXACT []
is_a: MP:0008936 ! abnormal pituitary gland size

[Term]
id: MP:0005362
name: abnormal Langerhans cell physiology
def: "atypical or failure of normal function of the stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal Langerhans cell function" EXACT []
is_a: MP:0002376 ! abnormal dendritic cell physiology

[Term]
id: MP:0005363
name: decreased susceptibility to prion infection
alt_id: MP:0003003
def: "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [MGI:cwg]
synonym: "reduced susceptibility to prion infection" EXACT []
synonym: "resistance to prion infection" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0020187 ! abnormal susceptibility to prion infection

[Term]
id: MP:0005364
name: increased susceptibility to prion infection
alt_id: MP:0003004
def: "increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [MGI:cwg]
synonym: "decreased resistance to prion infection" EXACT []
synonym: "susceptibility to prion infection" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0020187 ! abnormal susceptibility to prion infection

[Term]
id: MP:0005365
name: abnormal bile salt homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [https://orcid.org/0000-0002-0371-1954, MESH:D04.808.105]
synonym: "abnormal bile acid homeostasis" RELATED []
is_a: MP:0002118 ! abnormal lipid homeostasis

[Term]
id: MP:0005366
name: variegated coat color
def: "an irregular and random patchwork of two or more colors in the coat" [MGI:llw2]
synonym: "variegated coat colour" EXACT []
is_a: MP:0000372 ! irregular coat pigmentation

[Term]
id: MP:0005367
name: renal/urinary system phenotype
def: "the observable morphological and physiological characteristics of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005369
name: muscle phenotype
def: "the observable morphological and physiological characteristics of the mammalian tissue composed of contractile cells or fibers that effects movement of an organ or part of the body that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597, VT:0005369]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005370
name: liver/biliary system phenotype
def: "the observable morphological and physiological characteristics of the  mammalian liver, gall bladder, or bile ducts that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
synonym: "hepatobiliary system phenotype" EXACT []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005371
name: limbs/digits/tail phenotype
def: "the observable morphological and physiological characteristics of the subdivision of a mammalian organism that protrudes from the body that are manifested through development and lifespan" [] {comment="https://orcid.org/0000-0003-4606-0597", comment="UBERON:0000026"}
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005375
name: adipose tissue phenotype
def: "the observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005376
name: homeostasis/metabolism phenotype
def: "the observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005377
name: hearing/vestibular/ear phenotype
def: "the observable morphological and physiological characteristics of mammalian system responsible for the perception of spatial orientation and auditory stimuli that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005378
name: growth/size/body region phenotype
def: "the observable morphological and physiological characteristics related to the overall or change in physical magnitude or an anatomical structure which is a subpart of the whole organism manifested in a mammalian organism through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005379
name: endocrine/exocrine gland phenotype
def: "the observable morphological and physiological characteristics of an organ that functions as a secretory or excretory organ in a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005380
name: embryo phenotype
def: "the observable morphological and physiological characteristics of the manifested in a mammalian organism before birth, including embryonic and fetal stages and embryonic and extraembryonic tissues" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005381
name: digestive/alimentary phenotype
def: "the observable morphological and physiological characteristics of the mammalian system dedicated to the mechanical, chemical, and enzymatic processing of food that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005382
name: craniofacial phenotype
def: "the observable morphological and physiological characteristics of the face or head of a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005384
name: cellular phenotype
def: "the observable morphological and physiological characteristics of the basic structural and functional unit of all mammalian organisms that are manifested through development and lifespan" []
synonym: "cell phenotype" EXACT []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005385
name: cardiovascular system phenotype
def: "the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005386
name: behavior/neurological phenotype
alt_id: MP:0001350
def: "the observable actions or reactions of mammalian organisms that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]
synonym: "behaviour/neurological phenotype" EXACT []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005387
name: immune system phenotype
def: "the observable morphological and physiological characteristics of the mammalian system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005388
name: respiratory system phenotype
def: "the observable morphological and physiological characteristics of the mammalian system responsible for the exchange of oxygen and carbon dioxide with the environment that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005389
name: reproductive system phenotype
def: "the observable morphological and physiological characteristics of the mammalian organs associated with producing offspring that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
synonym: "reproduction phenotype" EXACT []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005390
name: skeleton phenotype
def: "the observable morphological and physiological characteristics of the bone, cartilage, teeth, tendons, ligaments and other associated tissues of the bony framework ot the body of a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005391
name: vision/eye phenotype
def: "the observable morphological and physiological characteristics of the mammalian spheroid organ and optic nerve that serve to detect light that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005394
name: taste/olfaction phenotype
def: "the observable morphological and physiological characteristics of the organs involved in and perception of taste and smell in a mammalian organism that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005395
name: obsolete other phenotype
comment: Term was obsoleted because it it invalid.
subset: Europhenome_Terms
subset: IMPC
is_obsolete: true
consider: MP:0000001

[Term]
id: MP:0005397
name: hematopoietic system phenotype
def: "the observable morphological and physiological characteristics of the mammalian blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan" [https://orcid.org/0000-0003-4606-0597]
synonym: "haematopoietic system phenotype" EXACT []
synonym: "haemopoietic system phenotype" EXACT []
synonym: "hemopoietic system phenotype" EXACT []
is_a: MP:0000001 ! mammalian phenotype

[Term]
id: MP:0005398
name: decreased susceptibility to fungal infection
def: "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "decreased susceptibility to mold infection" EXACT []
synonym: "decreased susceptibility to yeast infection" EXACT []
synonym: "increased resistance to fungal infection" EXACT []
synonym: "increased resistance to mold infection" EXACT []
synonym: "increased resistance to yeast infection" EXACT []
synonym: "reduced susceptibility to fungal infection" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0020183 ! abnormal susceptibility to fungal infection

[Term]
id: MP:0005399
name: increased susceptibility to fungal infection
def: "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "decreased resistance to fungal infection" EXACT []
synonym: "decreased resistance to mold infection" EXACT []
synonym: "decreased resistance to yeast infection" EXACT []
synonym: "increased susceptibility to mold infection" EXACT []
synonym: "increased susceptibility to yeast infection" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0020183 ! abnormal susceptibility to fungal infection

[Term]
id: MP:0005400
name: abnormal vitamin level
def: "any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function" [MESH:D27.505.696.377.605.600, MGI:cwg]
is_a: MP:0004019 ! abnormal vitamin homeostasis

[Term]
id: MP:0005401
name: abnormal fat-soluble vitamin level
def: "any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body" [MGI:cwg]
is_a: MP:0005400 ! abnormal vitamin level

[Term]
id: MP:0005402
name: abnormal action potential
def: "change in the electric response of a nerve or other excitable tissue to its stimulation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0005403
name: abnormal nerve conduction
def: "anomaly in the act of transmitting electricity along a single nerve" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0002272 ! abnormal nervous system electrophysiology

[Term]
id: MP:0005404
name: abnormal axon morphology
def: "any structural anomaly of the single process of a nerve cell that normally conducts impulses away from the cell body" [ISBN:0-683-40008-8]
synonym: "abnormal axonal morphology" EXACT []
synonym: "abnormal nerve fiber morphology" BROAD []
synonym: "abnormal nerve fibre morphology" BROAD []
is_a: MP:0008415 ! abnormal neurite morphology

[Term]
id: MP:0005405
name: axon degeneration
def: "retrogressive pathologic change in the single process of a nerve cell" [ISBN:0-683-40008-8]
synonym: "axonal degeneration" EXACT []
is_a: MP:0002229 ! neurodegeneration

[Term]
id: MP:0005406
name: abnormal heart size
def: "change from normal in the physical magnitude of the cardiac muscle or any of its component structures" [MGI:cwg]
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0005407
name: hyperalgesia
def: "increased sensitivity to painful stimuli; can be due to inflammatory response or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MESH:C10.597.751.791.400]
synonym: "decreased pain threshold" EXACT []
is_a: MP:0001970 ! abnormal pain threshold

[Term]
id: MP:0005408
name: hypopigmentation
def: "dilution of pigment in any or all tissues or a part of a tissue" [MGI:llw2]
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0005409
name: darkened coat color
def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased when compared to wild-type agouti" [MGI:llw2]
synonym: "darkened coat colour" EXACT []
synonym: "mahogany coat color" NARROW []
synonym: "mahogany coat colour" NARROW []
is_a: MP:0012076 ! abnormal agouti pigmentation

[Term]
id: MP:0005410
name: abnormal fertilization
def: "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0001919 ! abnormal reproductive system physiology

[Term]
id: MP:0005411
name: delayed fertilization
def: "a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0005410 ! abnormal fertilization

[Term]
id: MP:0005412
name: vascular stenosis
def: "abnormal narrowing or constriction of the lumen of one or more blood vessels" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0005413
name: vascular restenosis
def: "recurrence of a narrowing or constriction of a blood vessel following surgical or mechanical removal or reduction of a previous narrowing" [ISBN:0-683-40008-8]
is_a: MP:0005412 ! vascular stenosis

[Term]
id: MP:0005414
name: extrahepatic cholestasis
def: "impairment of bile flow in the large bile ducts by mechanical obstruction or stricture due to benign or malignant process" [MESH:C06.130.120.135.150]
synonym: "extrahepatic bile duct obstruction" EXACT []
synonym: "extrahepatic bile stasis" EXACT []
synonym: "extrahepatic biliary stasis" EXACT []
is_a: MP:0000610 ! cholestasis

[Term]
id: MP:0005415
name: intrahepatic cholestasis
def: "impairment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MESH:C06.130.120.135.250]
synonym: "intrahepatic bile duct obstruction" EXACT []
synonym: "intrahepatic bile stasis" EXACT []
synonym: "intrahepatic biliary stasis" EXACT []
is_a: MP:0000609 ! abnormal liver physiology
is_a: MP:0000610 ! cholestasis

[Term]
id: MP:0005416
name: abnormal circulating protein level
def: "anomaly in the amount in the blood of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal blood protein level" EXACT []
is_a: MP:0008469 ! abnormal protein level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0005418
name: abnormal circulating hormone level
def: "any anomaly in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MESH:D06.472, MGI:cwg]
is_a: MP:0003953 ! abnormal hormone level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0005419
name: decreased circulating serum albumin level
def: "blood serum albumin concentration below the normal range" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypoalbuminaemia" EXACT []
synonym: "hypoalbuminemia" EXACT []
synonym: "reduced circulating serum albumin level" EXACT []
is_a: MP:0000199 ! abnormal circulating serum albumin level
is_a: MP:0014502 ! decreased circulating protein level

[Term]
id: MP:0005421
name: loose skin
def: "condition in which the skin hangs in folds" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "cutis laxa" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0005422
name: osteosclerosis
def: "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone" [ISBN:0-683-40008-8, MGI:cml]
synonym: "bone sclerosis" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0005423
name: abnormal somatic nervous system physiology
def: "any functional anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0005424
name: jerky movement
def: "continuous, abrupt, faltering motions of the whole body or a portion of the body" [MGI:llw2]
synonym: "choreic movement" EXACT []
synonym: "twitching" EXACT []
synonym: "waltzing" EXACT []
is_a: MP:0001516 ! abnormal motor coordination/balance

[Term]
id: MP:0005425
name: increased macrophage cell number
def: "greater than the normal numbers of macrophages" [MGI:cwg]
synonym: "increased macrophage count" RELATED []
synonym: "increased macrophage numbers" EXACT []
is_a: MP:0000218 ! increased leukocyte cell number
is_a: MP:0020202 ! abnormal macrophage cell number

[Term]
id: MP:0005426
name: tachypnea
def: "rapid breathing" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "polypnea" EXACT []
is_a: MP:0005573 ! increased pulmonary respiratory rate

[Term]
id: MP:0005428
name: obsolete abnormal clinical chemistry
def: "OBSOLETE. any anomaly in the laboratory tests that show the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease" [MGI:cwg]
comment: This term has been rendered obsolete. This really refers to groups of clinical tests and measurements, not the underlying phenotype.
is_obsolete: true

[Term]
id: MP:0005429
name: obsolete abnormal pine bedding color after urinary excretion
def: "OBSOLETE. with normal urine coloration, a change in the hue of the pine bedding of a mouse, often to a bright yellow or chartreuse, after excretion of urine by the animal housed with this type of bedding; indicative of a metabolic defect" [https://orcid.org/0000-0003-3691-0324, MGI:cwg, MGI:llw2]
is_obsolete: true

[Term]
id: MP:0005430
name: absent fibula
def: "absence of the lateral and shorter of the two bones of the lower leg" [https://orcid.org/0000-0002-0371-1954]
synonym: "absence of fibula" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology

[Term]
id: MP:0005431
name: decreased oocyte number
def: "reduced numbers of germ cells in the female" [MGI:cwg, MGI:llw2]
synonym: "decreased number of oocytes" EXACT []
synonym: "decreased oocyte cell number" EXACT []
synonym: "female germ cell depletion" EXACT []
synonym: "oocyte depletion" EXACT []
synonym: "reduced number of oocytes" EXACT []
synonym: "reduced oocyte cell number" EXACT []
is_a: MP:0002209 ! decreased germ cell number
is_a: MP:0020152 ! abnormal oocyte number

[Term]
id: MP:0005432
name: abnormal pro-B cell morphology
def: "any structural anomaly of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal B cell progenitor" EXACT []
synonym: "abnormal progenitor B cell" EXACT []
synonym: "pro-B cell abnormalities" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0005433
name: absent early pro-B cells
def: "absence of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0002-0371-1954, ISBN:0-8153-1691-7]
synonym: "deficiency of early pro-B cells" EXACT []
is_a: MP:0014403 ! decreased early pro-B cell number

[Term]
id: MP:0005434
name: absent late pro-B cells
def: "absence of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0002-0371-1954, ISBN:0-8153-1691-7]
synonym: "deficiency of late pro-B cells" EXACT []
is_a: MP:0014404 ! decreased late pro-B cell number

[Term]
id: MP:0005435
name: hemoperitoneum
def: "blood in the peritoneal cavity" [https://orcid.org/0000-0002-0371-1954, ISBN:0-683-40008-8]
synonym: "haematoperitoneum" EXACT []
synonym: "haemoperitoneum" EXACT []
synonym: "hematoperitoneum" EXACT []
synonym: "peritoneal cavity haemorrhage" EXACT []
synonym: "peritoneal cavity hemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage

[Term]
id: MP:0005437
name: abnormal glycogen level
def: "any anomaly in the concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0005438 ! abnormal glycogen homeostasis

[Term]
id: MP:0005438
name: abnormal glycogen homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of glycogen, a readily converted carbohydrate reserve found in most tissues of the body, especially liver and muscle" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0002078 ! abnormal glucose homeostasis

[Term]
id: MP:0005439
name: decreased glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "reduced glycogen level" EXACT []
is_a: MP:0005437 ! abnormal glycogen level

[Term]
id: MP:0005440
name: increased glycogen level
def: "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0005437 ! abnormal glycogen level

[Term]
id: MP:0005441
name: increased urine calcium level
def: "abnormally large amounts of calcium in the urine" [ISBN:0-683-40008-8]
synonym: "hypercalcinuria" EXACT []
synonym: "hypercalciuria" EXACT []
synonym: "hypercalcuria" EXACT []
is_a: MP:0002985 ! abnormal urine calcium level
is_a: MP:0014537 ! increased calcium level

[Term]
id: MP:0005442
name: obsolete abnormal pyramidal neuron morphology
def: "OBSOLETE. any structural anomaly of the projection neurons in the cerebral cortex and hippocampus" []
synonym: "abnormal pyramidal cell" EXACT []
is_obsolete: true
consider: MP:0009940
consider: MP:0009969

[Term]
id: MP:0005443
name: abnormal ethanol metabolism
def: "altered ability to metabolize the clear, colorless liquid that has formula C2H6O" [CHEBI:16236, MGI:cwg]
synonym: "abnormal alcohol metabolism" EXACT []
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0005444
name: abnormal retinol metabolism
def: "altered ability to metabolize retinol, which plays an essential role in metabolic functioning of the retina, and growth of and differentiation" [ISBN:0-683-40008-8]
synonym: "abnormal vitamin A1 metabolism" EXACT []
is_a: MP:0011233 ! abnormal vitamin A metabolism

[Term]
id: MP:0005445
name: abnormal neurotransmitter secretion
def: "anomaly in the production or release of endogenous signaling molecules into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell" [GO:0007269, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neurotransmitter release" EXACT []
synonym: "abnormal synaptic release" EXACT []
is_a: MP:0003635 ! abnormal synaptic transmission

[Term]
id: MP:0005446
name: abnormal synaptic epinephrine release
def: "aberrant secretion across synapses of the active sympathomimetic hormone that stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MGI:cwg]
synonym: "abnormal synaptic adrenaline release" EXACT []
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0005447
name: abnormal synaptic norepinephrine release
def: "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [MGI:cwg]
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0005448
name: abnormal energy homeostasis
def: "any anomaly in the process involved in the balance between food intake (energy input) and energy expenditure" [GO:0097009]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal energy balance" EXACT []
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0005449
name: abnormal food intake
def: "any anomaly in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal calorie consumption" EXACT []
synonym: "abnormal energy intake" EXACT []
synonym: "abnormal food consumption" EXACT []
synonym: "abnormal ingestion" EXACT []
is_a: MP:0001431 ! abnormal eating behavior

[Term]
id: MP:0005450
name: abnormal energy expenditure
def: "utilization of calories that differs from normal" [MGI:cwg]
synonym: "abnormal energy efficiency" EXACT []
synonym: "abnormal energy metabolism" EXACT []
is_a: MP:0005448 ! abnormal energy homeostasis

[Term]
id: MP:0005451
name: abnormal body composition
def: "aberrant relative amount and distribution of bone, body fat, muscle or lean tissue mass" [MPD:Molly]
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0005452
name: abnormal adipose tissue amount
def: "more or less than the normal total amount of connective tissue composed of fat cells" [MGI:cwg]
synonym: "abnormal body fat amount" RELATED []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0005455
name: increased susceptibility to weight gain
def: "greater increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:cwg]
synonym: "increased weight gain" RELATED []
is_a: MP:0011117 ! abnormal susceptibility to weight gain

[Term]
id: MP:0005456
name: obsolete weight gain
def: "OBSOLETE. increase in weight over existing weight" [MESH:C23.888.144.243.926]
is_obsolete: true
consider: MP:0001260
consider: MP:0005455
consider: MP:0010182
consider: MP:0011117

[Term]
id: MP:0005457
name: abnormal percent body fat/body weight
def: "more or less fat, relative to controls, expressed as a percentage of total body weight" [MGI:cwg]
synonym: "abnormal fat/body weight ratio" EXACT []
synonym: "abnormal percent body fat" EXACT []
synonym: "abnormal percentage body fat" EXACT []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0005458
name: increased percent body fat/body weight
def: "more fat, relative to controls, expressed as a percentage of total body weight" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "increased percent body fat" EXACT []
synonym: "increased percentage body fat" EXACT []
is_a: MP:0005457 ! abnormal percent body fat/body weight

[Term]
id: MP:0005459
name: decreased percent body fat/body weight
def: "less fat, relative to controls, expressed as a percentage of total body weight" [MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased percent body fat" EXACT []
synonym: "decreased percentage body fat" EXACT []
synonym: "reduced percent body fat" EXACT []
is_a: MP:0005457 ! abnormal percent body fat/body weight

[Term]
id: MP:0005460
name: abnormal leukopoiesis
alt_id: MP:0002430
alt_id: MP:0002449
def: "any anomaly in the process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MESH:G04.335.151.825.597]
synonym: "abnormal immune cell development" EXACT []
synonym: "abnormal leucocyte differentiation" EXACT []
synonym: "abnormal leucocyte morphology/development" EXACT []
synonym: "abnormal leucocytopoiesis" EXACT []
synonym: "abnormal leucopoiesis" EXACT []
synonym: "abnormal leukocyte differentiation" EXACT []
synonym: "abnormal leukocyte morphology/development" EXACT []
synonym: "abnormal leukocytopoiesis" EXACT []
synonym: "immune cell developmental abnormalities" EXACT []
is_a: MP:0000716 ! abnormal immune system cell morphology
is_a: MP:0002123 ! abnormal definitive hematopoiesis
is_a: MP:0020981 ! abnormal immune system development

[Term]
id: MP:0005461
name: abnormal dendritic cell morphology
def: "any structural anomaly of a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
comment: Do not confuse with abnormal follicular dendritic cell morphology (MP:0008196).
is_a: MP:0008195 ! abnormal professional antigen presenting cell morphology
is_a: MP:0008246 ! abnormal leukocyte morphology

[Term]
id: MP:0005462
name: abnormal mast cell differentiation
def: "atypical production of or inability to produce a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation" [MESH:A.11.329.427]
is_a: MP:0000359 ! abnormal mast cell morphology
is_a: MP:0008111 ! abnormal granulocyte differentiation

[Term]
id: MP:0005463
name: abnormal CD4-positive, alpha-beta T cell physiology
def: "any functional anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:cwg]
synonym: "abnormal CD4+ T cell function" EXACT []
synonym: "abnormal CD4+ T cell physiology" EXACT []
synonym: "abnormal CD4-positive T cell physiology" EXACT []
synonym: "abnormal single positive T cell physiology" BROAD []
synonym: "CD4+ T cell dysfunction" EXACT []
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0005464
name: abnormal platelet physiology
def: "any functional anomaly of the non-nucleated cells found in the blood and involved in blood coagulation" [MESH:A11.118.188, MGI:cwg]
synonym: "abnormal platelet function" EXACT []
synonym: "abnormal thrombocyte physiology" EXACT []
is_a: MP:0002551 ! abnormal blood coagulation
is_a: MP:0012382 ! abnormal blood cell physiology

[Term]
id: MP:0005465
name: abnormal T-helper 1 physiology
def: "abnormal function of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
synonym: "abnormal helper T cell type 1 function" EXACT []
synonym: "abnormal helper T lymphocyte type 1 function" EXACT []
synonym: "abnormal helper T-cell type 1 function" EXACT []
synonym: "abnormal helper T-lymphocyte type 1 function" EXACT []
synonym: "abnormal T helper 1 function" EXACT []
synonym: "abnormal TH1 cell function" EXACT []
synonym: "T helper 1 functional abnormalities" EXACT []
synonym: "TH1 functional abnormalities" EXACT []
synonym: "Th1 functional abnormalities" EXACT []
is_a: MP:0005463 ! abnormal CD4-positive, alpha-beta T cell physiology

[Term]
id: MP:0005466
name: abnormal T-helper 2 physiology
def: "abnormal function of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149]
synonym: "abnormal helper T cell type 2 function" EXACT []
synonym: "abnormal helper T lymphocyte type 2 function" EXACT []
synonym: "abnormal helper T-cell type 2 function" EXACT []
synonym: "abnormal helper T-lymphocyte type 2 function" EXACT []
synonym: "abnormal T helper 2 function" EXACT []
synonym: "abnormal T helper 2 physiology" EXACT []
synonym: "abnormal TH2 cell function" EXACT []
synonym: "T helper 2 functional abnormalities" EXACT []
synonym: "TH2 functional abnormalities" EXACT []
synonym: "Th2 functional abnormalities" EXACT []
is_a: MP:0005463 ! abnormal CD4-positive, alpha-beta T cell physiology

[Term]
id: MP:0005467
name: obsolete abnormal chemotactic leukotriene physiology
def: "OBSOLETE. functional anomaly of any of a subset of leukotrienes that are involved in attracting leukocytes to a site of tissue injury" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005468
name: abnormal thyroid hormone level
def: "aberrant concentration of any of the hormones secreted by the thyroid gland" [MESH:D06.472.931, MGI:cwg]
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0005469
name: abnormal thyroxine level
def: "any anomaly in the concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
synonym: "abnormal T4 level" EXACT []
synonym: "abnormal thyroxin level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
is_a: MP:0005468 ! abnormal thyroid hormone level
is_a: MP:0021145 ! abnormal amino acid derivative level

[Term]
id: MP:0005470
name: increased thyroxine level
def: "greater than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
synonym: "increased T4 level" EXACT []
synonym: "increased thyroxin level" EXACT []
is_a: MP:0005469 ! abnormal thyroxine level
is_a: MP:0014527 ! increased amino acid level

[Term]
id: MP:0005471
name: decreased thyroxine level
def: "less than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
synonym: "decreased T4 level" EXACT []
synonym: "decreased thyroxin level" EXACT []
synonym: "reduced T4 level" EXACT []
synonym: "reduced thyroxin level" EXACT []
synonym: "reduced thyroxine level" EXACT []
is_a: MP:0005469 ! abnormal thyroxine level
is_a: MP:0014455 ! decreased hormone level
is_a: MP:0014528 ! decreased amino acid level

[Term]
id: MP:0005472
name: abnormal triiodothyronine level
def: "anomaly in the amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "abnormal T3 level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
is_a: MP:0005468 ! abnormal thyroid hormone level

[Term]
id: MP:0005473
name: decreased triiodothyronine level
def: "reduced amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "decreased T3 level" EXACT []
synonym: "reduced T3 level" EXACT []
synonym: "reduced triiodothyronine level" EXACT []
is_a: MP:0005472 ! abnormal triiodothyronine level
is_a: MP:0014455 ! decreased hormone level

[Term]
id: MP:0005474
name: increased triiodothyronine level
def: "greater amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "increased T3 level" EXACT []
is_a: MP:0005472 ! abnormal triiodothyronine level

[Term]
id: MP:0005475
name: abnormal circulating thyroxine level
def: "anomaly in the blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
synonym: "abnormal circulating level of T4" EXACT []
synonym: "abnormal circulating level of thryoxin" EXACT []
synonym: "abnormal circulating level of thryoxine" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0005469 ! abnormal thyroxine level

[Term]
id: MP:0005476
name: abnormal circulating triiodothyronine level
def: "anomaly in the amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "abnormal circulating level of T3" EXACT []
synonym: "abnormal circulating level of triiodothyronine" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0005472 ! abnormal triiodothyronine level

[Term]
id: MP:0005477
name: increased circulating thyroxine level
def: "greater than the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "increased circulating level of T4" EXACT []
synonym: "increased circulating level of thyroxin" EXACT []
synonym: "increased circulating level of thyroxine" EXACT []
is_a: MP:0003350 ! increased circulating levels of thyroid hormone
is_a: MP:0005470 ! increased thyroxine level
is_a: MP:0005475 ! abnormal circulating thyroxine level
is_a: MP:0014530 ! increased circulating amino acid level

[Term]
id: MP:0005478
name: decreased circulating thyroxine level
def: "reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism" [MESH:D06.472.931.812, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating level of T4" EXACT []
synonym: "decreased circulating level of thyroxin" EXACT []
synonym: "decreased circulating level of thyroxine" EXACT []
synonym: "reduced circulating thyroxine level" EXACT []
is_a: MP:0003351 ! decreased circulating levels of thyroid hormone
is_a: MP:0005471 ! decreased thyroxine level
is_a: MP:0005475 ! abnormal circulating thyroxine level
is_a: MP:0014531 ! decreased circulating amino acid level

[Term]
id: MP:0005479
name: decreased circulating triiodothyronine level
def: "reduced amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "decreased circulating level of T3" EXACT []
synonym: "decreased circulating level of triiodothyronine" EXACT []
synonym: "reduced circulating triiodothyronine level" EXACT []
is_a: MP:0003351 ! decreased circulating levels of thyroid hormone
is_a: MP:0005473 ! decreased triiodothyronine level
is_a: MP:0005476 ! abnormal circulating triiodothyronine level

[Term]
id: MP:0005480
name: increased circulating triiodothyronine level
def: "greater amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland" [ISBN:0-683-40008-8, ISBN:978-0-323-05290-0]
synonym: "increased circulating level of T3" EXACT []
synonym: "increased circulating level of triiodothyronine" EXACT []
is_a: MP:0003350 ! increased circulating levels of thyroid hormone
is_a: MP:0005474 ! increased triiodothyronine level
is_a: MP:0005476 ! abnormal circulating triiodothyronine level

[Term]
id: MP:0005481
name: increased chronic myelocytic leukemia incidence
def: "higher than normal incidence of a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages" [ISBN:0-683-40008-8]
synonym: "chronic granulocytic leukaemia" RELATED []
synonym: "chronic granulocytic leukemia" RELATED []
synonym: "chronic myelocytic leukaemia" RELATED []
synonym: "chronic myelocytic leukemia" RELATED []
synonym: "chronic myelogenous leukaemia" RELATED []
synonym: "chronic myelogenous leukemia" RELATED []
synonym: "chronic myeloid leukaemia" RELATED []
synonym: "chronic myeloid leukemia" RELATED []
synonym: "CML" RELATED []
synonym: "increased chronic myelocytic leukaemia incidence" EXACT []
is_a: MP:0002026 ! increased leukemia incidence

[Term]
id: MP:0005482
name: obsolete cellular hypertrophy
def: "OBSOLETE. increased size or bulk of a cell, without accompanying increased numbers" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005483
name: obsolete cellular hyperplasia
def: "OBSOLETE. an increase in the number of cells in an organ or tissue" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005485
name: obsolete cellular dysplasia
def: "OBSOLETE. change in the size, shape, and organization of the cellular components of a tissue" [ISBN:0-397-51047-0, MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005486
name: obsolete cellular metaplasia
def: "OBSOLETE. conversion of one differentiated cell type to another" [ISBN:0-397-51047-0]
is_obsolete: true

[Term]
id: MP:0005487
name: obsolete cellular hypoplasia
def: "OBSOLETE. a decrease in the number of cells in an organ or tissue" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005488
name: bronchial epithelial hyperplasia
def: "increase in the number of normal cells in normal arrangement in the bronchial epithelium, typically resulting in increased size" [MGI:cwg]
synonym: "hyperplastic bronchial epithelium" EXACT []
is_a: MP:0010943 ! abnormal bronchus epithelium morphology

[Term]
id: MP:0005489
name: vascular smooth muscle hyperplasia
def: "increase in the number of normal cells in normal arrangement in the vascular smooth muscle, typically resulting in increased size" [MGI:cwg]
synonym: "hyperplastic vascular smooth muscle" EXACT []
synonym: "vascular smooth muscle cell hyperplasia" EXACT []
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology

[Term]
id: MP:0005490
name: increased club cell number
def: "increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [ISBN:0-683-40008-8]
synonym: "club cell hyperplasia" EXACT []
synonym: "increased bronchiolar exocrine cell number" EXACT []
synonym: "increased Clara cell number" EXACT []
is_a: MP:0010809 ! abnormal club cell morphology

[Term]
id: MP:0005491
name: pancreatic islet hyperplasia
def: "increase in the number of normal cells in normal arrangement in the pancreatic islets, typically resulting in increased size" [MESH:A03.734.414, MGI:cwg]
synonym: "hyperplastic pancreatic islets" EXACT []
is_a: MP:0009171 ! enlarged pancreatic islets

[Term]
id: MP:0005492
name: exocrine pancreas hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the exocrine pancreas, typically resulting in decreased size" [MESH:A03.734.540]
synonym: "decreased exocrine pancreas cellularity" RELATED []
synonym: "exocrine pancreatic hypoplasia" EXACT []
synonym: "hypoplastic exocrine pancreas" EXACT []
is_a: MP:0005220 ! abnormal exocrine pancreas morphology
is_a: MP:0009111 ! pancreas hypoplasia

[Term]
id: MP:0005493
name: stomach epithelial hyperplasia
def: "increase in the number of normal cells in normal arrangement in the stomach epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "gastric epithelial hyperplasia" EXACT []
synonym: "hyperplastic gastric epithelium" EXACT []
is_a: MP:0000471 ! abnormal stomach epithelium morphology

[Term]
id: MP:0005494
name: esophagogastric junction metaplasia
def: "conversion of one differentiated cell type to another differentiated cell type at the terminal end of the esophagus and beginning of the stomach" [ISBN:0-683-40008-8]
synonym: "G-E junction metaplasia" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0005213 ! gastric metaplasia

[Term]
id: MP:0005497
name: optic nerve cupping
def: "concave shape of the nerve often as a result of the force of pressure from glaucoma" [MGI:cwg]
synonym: "cupping of optic nerve" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0005498
name: hyporesponsive to tactile stimuli
alt_id: MP:0001979
def: "reduced reflex action normally induced by touch or pain" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased pain responsiveness in tail flick test" EXACT []
synonym: "tactile hypoalgesia" RELATED []
is_a: MP:0003043 ! hypoalgesia
is_a: MP:0005316 ! abnormal response to tactile stimuli

[Term]
id: MP:0005499
name: abnormal olfactory system morphology
def: "any structural anomaly of the organs involved in smell" [MGI:cwg]
synonym: "olfactory system dysplasia" NARROW []
is_a: MP:0005394 ! taste/olfaction phenotype

[Term]
id: MP:0005500
name: abnormal gustatory system morphology
def: "any structural anomaly of the organs involved in taste" [ISBN:0-683-40008-8]
synonym: "gustatory system dysplasia" NARROW []
is_a: MP:0005394 ! taste/olfaction phenotype

[Term]
id: MP:0005501
name: abnormal skin physiology
def: "any functional anomaly of the membranous protective covering of the body" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0010771 ! integument phenotype

[Term]
id: MP:0005502
name: abnormal renal/urinary system physiology
def: "any functional anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal urinary system function" EXACT []
is_a: MP:0005367 ! renal/urinary system phenotype

[Term]
id: MP:0005503
name: abnormal tendon morphology
def: "any structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MESH:A02.880]
synonym: "tendon dysplasia" RELATED []
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0005504
name: abnormal ligament morphology
def: "any structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones" [MESH:A02.513]
synonym: "ligament dysplasia" NARROW []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0005505
name: thrombocytosis
def: "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased platelet cell number" EXACT []
synonym: "increased platelet count" EXACT []
synonym: "increased thrombocyte number" RELATED []
is_a: MP:0011898 ! abnormal platelet cell number
is_a: MP:0013663 ! increased myeloid cell number

[Term]
id: MP:0005506
name: obsolete abnormal limbs/digits/tail physiology
def: "OBSOLETE. functional anomaly of the digits, paws, limbs, or tail" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005507
name: tail dragging
def: "pulling the tail along with difficulty or effort; may be due to paralysis or weakness" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001391 ! abnormal tail movements

[Term]
id: MP:0005508
name: abnormal skeleton morphology
alt_id: MP:0000055
def: "any structural anomaly of the bony framework of the body in vertebrates" [ISBN:0-683-40008-8]
synonym: "abnormal bone/ skeleton" EXACT []
synonym: "bone/ skeletal abnormalities" EXACT []
is_a: MP:0005390 ! skeleton phenotype

[Term]
id: MP:0005515
name: uveitis
def: "inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina)" [MESH:C11.941.879, RGD:cur]
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0005516
name: enhanced liver regeneration
def: "increase in the renewal, repair, and/or regrowth of liver tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced hepatic regeneration" EXACT []
synonym: "improved hepatic regeneration" EXACT []
synonym: "improved liver regeneration" EXACT []
synonym: "increased hepatic regeneration" EXACT []
synonym: "increased liver regeneration" EXACT []
is_a: MP:0002658 ! abnormal liver regeneration

[Term]
id: MP:0005517
name: impaired liver regeneration
def: "decrease in the renewal, repair, and/or regrowth of liver tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased hepatic regeneration" EXACT []
synonym: "decreased liver regeneration" EXACT []
synonym: "impaired hepatic regeneration" EXACT []
synonym: "reduced hepatic regeneration" EXACT []
synonym: "reduced liver regeneration" EXACT []
is_a: MP:0002658 ! abnormal liver regeneration

[Term]
id: MP:0005518
name: abnormal pancreas regeneration
def: "anomaly in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pancreatic regeneration" EXACT []
is_a: MP:0002693 ! abnormal pancreas physiology

[Term]
id: MP:0005519
name: enhanced pancreas regeneration
def: "increase in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced pancreatic regeneration" EXACT []
synonym: "improved pancreas regeneration" EXACT []
synonym: "improved pancreatic regeneration" EXACT []
synonym: "increased pancreas regeneration" EXACT []
synonym: "increased pancreatic regeneration" EXACT []
is_a: MP:0005518 ! abnormal pancreas regeneration

[Term]
id: MP:0005520
name: impaired pancreas regeneration
def: "decrease in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased pancreas regeneration" EXACT []
synonym: "decreased pancreatic regeneration" EXACT []
synonym: "impaired pancreatic regeneration" EXACT []
synonym: "reduced pancreas regeneration" EXACT []
synonym: "reduced pancreatic regeneration" EXACT []
is_a: MP:0005518 ! abnormal pancreas regeneration

[Term]
id: MP:0005521
name: abnormal circulating atrial natriuretic factor level
def: "deviation from the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator" [MESH:D06.472.699.584.500, RGD:cur]
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005522
name: increased circulating atrial natriuretic factor
def: "greater than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator" [MESH:D06.472.699.584.500, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
synonym: "enhanced circulating atrial natriuretic factor" EXACT []
synonym: "increased circulating ANF" EXACT []
is_a: MP:0005521 ! abnormal circulating atrial natriuretic factor level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005523
name: decreased circulating atrial natriuretic factor
def: "less than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator" [MESH:D06.472.699.584.500, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased circulating ANF" EXACT []
synonym: "reduced circulating atrial natriuretic factor" EXACT []
is_a: MP:0005521 ! abnormal circulating atrial natriuretic factor level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005524
name: abnormal renal plasma flow rate
def: "deviation from the normal volume of plasma passing through the kidney per unit time" [MGI:cwg, RGD:cur]
is_a: MP:0000233 ! abnormal blood flow velocity
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0005525
name: increased renal plasma flow rate
def: "greater than the normal volume of plasma passing through the kidney per unit time" [MGI:cwg, RGD:cur]
is_a: MP:0005524 ! abnormal renal plasma flow rate

[Term]
id: MP:0005526
name: decreased renal plasma flow rate
def: "less than the normal volume of plasma passing through the kidney per unit time" [MGI:cwg, RGD:cur]
synonym: "reduced renal plasma flow rate" EXACT []
is_a: MP:0005524 ! abnormal renal plasma flow rate

[Term]
id: MP:0005527
name: increased renal glomerular filtration rate
def: "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time" [MESH:E01.370.390.400.300, MGI:cwg]
synonym: "increased GFR" EXACT []
synonym: "increased kidney glomerular filtration rate" EXACT []
is_a: MP:0002847 ! abnormal renal glomerular filtration rate

[Term]
id: MP:0005528
name: decreased renal glomerular filtration rate
def: "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time" [MESH:E01.370.390.400.300, MGI:cwg]
synonym: "decreased GFR" EXACT []
synonym: "decreased kidney glomerular filtration rate" EXACT []
synonym: "reduced kidney glomerular filtration rate" EXACT []
synonym: "reduced renal glomerular filtration rate" EXACT []
is_a: MP:0002847 ! abnormal renal glomerular filtration rate

[Term]
id: MP:0005529
name: abnormal renal vascular resistance
def: "deviation from the normal force opposing blood flow in the kidney blood vessels" [MGI:cwg, RGD:cur]
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0005532 ! abnormal vascular resistance

[Term]
id: MP:0005530
name: decreased renal vascular resistance
def: "less than the normal force opposing blood flow in the kidney blood vessels" [MGI:cwg, RGD:cur]
synonym: "reduced renal vascular resistance" EXACT []
is_a: MP:0005529 ! abnormal renal vascular resistance

[Term]
id: MP:0005531
name: increased renal vascular resistance
def: "greater than the normal force opposing blood flow in the kidney blood vessels" [MGI:cwg, RGD:cur]
is_a: MP:0005529 ! abnormal renal vascular resistance

[Term]
id: MP:0005532
name: abnormal vascular resistance
def: "deviation from the normal force opposing the flow of blood through a vascular bed; it is equal to the difference in blood pressure across the vascular bed divided by the cardiac output" [MESH:G09.330.553.660.921, MGI:cwg]
synonym: "abnormal peripheral resistance" EXACT []
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0005533
name: increased body temperature
def: "greater than the level of heat natural to a living being" [ISBN:0-683-40008-8, MGI:cwg, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0005535 ! abnormal body temperature

[Term]
id: MP:0005534
name: decreased body temperature
alt_id: MP:0005038
def: "less than the level of heat natural to a living being" [ISBN:0-683-40008-8, MGI:cwg, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypothermia" EXACT []
synonym: "reduced body temperature" EXACT []
is_a: MP:0005535 ! abnormal body temperature

[Term]
id: MP:0005535
name: abnormal body temperature
def: "deviation in the level of heat natural to a living being" [ISBN:0-683-40008-8, MGI:cwg, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0005536
name: decreased Leydig cell number
def: "decreased number of the interstitial cells found adjacent to the seminiferous tubules in the testicle that produce testosterone in the presence of luteinizing hormone" [https://orcid.org/0000-0002-0371-1954]
synonym: "Leydig cell hypoplasia" NARROW []
synonym: "reduced Leydig cell number" EXACT []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0005537
name: abnormal cerebral aqueduct morphology
def: "any structural anomaly of the channel in the mesencephalon that connects the third and fourth ventricles" [MESH:A08.186.211.132.659.822.187, MGI:hdene]
synonym: "abnormal aqueduct of midbrain morphology" EXACT []
synonym: "abnormal aqueduct of Sylvius" EXACT []
synonym: "abnormal aqueductus mesencephali morphology" EXACT []
synonym: "abnormal cerebral aqueduct of Sylvius morphology" RELATED []
synonym: "abnormal mesencephalic duct morphology" EXACT []
synonym: "abnormal mesencephalic vesicle morphology" EXACT []
synonym: "abnormal midbrain cerebral aqueduct morphology" EXACT []
synonym: "abnormal Sylvian aqueduct morphology" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0005540
name: decreased urine albumin level
alt_id: MP:0005538
def: "less than the normal amount of albumin in the urine" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "decreased albumin excretion" EXACT []
synonym: "decreased albumin in urine" EXACT []
synonym: "reduced albumin excretion" EXACT []
is_a: MP:0002963 ! decreased urine protein level

[Term]
id: MP:0005541
name: abnormal iris stromal pigmentation
def: "any anomaly in the coloring of the framework of the iris" [MGI:cwg]
is_a: MP:0005102 ! abnormal iris pigmentation
is_a: MP:0005208 ! abnormal iris stroma morphology

[Term]
id: MP:0005542
name: cornea vascularization
def: "formation of blood vessels in the cornea, which normally lacks vessels" [ISBN:0-683-40008-8, MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "corneal vascularization" EXACT []
synonym: "tunica cornea vascularization" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
is_a: MP:0003711 ! pathological neovascularization

[Term]
id: MP:0005543
name: decreased cornea thickness
def: "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:cwg]
synonym: "corneal thinning" EXACT []
synonym: "decreased corneal thickness" EXACT []
synonym: "decreased tunica cornea thickness" EXACT []
synonym: "reduced cornea thickness" EXACT []
synonym: "thin cornea" EXACT []
is_a: MP:0011961 ! abnormal cornea thickness

[Term]
id: MP:0005544
name: cornea deposits
def: "accumulation of minerals, proteins, or other anomalous substances on the cornea" [MGI:cwg]
synonym: "corneal deposits" EXACT []
synonym: "tunica cornea deposits" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0005545
name: abnormal lens development
def: "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [MGI:cwg]
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001303 ! abnormal lens morphology

[Term]
id: MP:0005546
name: choroidal neovascularization
def: "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0003711 ! pathological neovascularization
is_a: MP:0006237 ! abnormal choroid vasculature morphology

[Term]
id: MP:0005547
name: abnormal Muller cell morphology
def: "any structural anomaly of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [ISBN:0-683-40008-8, MGI:cwg]
synonym: "abnormal Mueller cell morphology" EXACT []
synonym: "abnormal Muller fiber morphology" EXACT [ISBN:0-683-40008-8]
synonym: "abnormal Muller fibre morphology" EXACT []
synonym: "abnormal Muller radial cell morphology" EXACT []
is_a: MP:0000952 ! abnormal CNS glial cell morphology
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0005548
name: retina pigment epithelium atrophy
def: "acquired diminution of the size of the epithelial layer of the retina composed of cells containing pigment granules, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, MGI:cwg]
synonym: "atrophy of retinal pigment epithelium" EXACT []
synonym: "retinal pigment epithelium atrophy" EXACT []
is_a: MP:0005201 ! abnormal retina pigment epithelium morphology

[Term]
id: MP:0005549
name: retina pigment epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the retinal pigment epithelium, typically resulting in increased size" [MGI:cwg]
synonym: "hyperplasia of retinal pigment epithelium" EXACT []
synonym: "hyperplastic retina pigment epithelium" EXACT []
synonym: "hyperplastic retinal pigment epithelium" EXACT []
synonym: "retinal pigment epithelium hyperplasia" EXACT []
is_a: MP:0005201 ! abnormal retina pigment epithelium morphology

[Term]
id: MP:0005550
name: obsolete orbital hemorrhage
def: "OBSOLETE. escape of blood into the orbit" [MGI:cwg]
is_obsolete: true

[Term]
id: MP:0005551
name: abnormal eye electrophysiology
def: "any functional anomaly of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [MGI:pretel]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0005552
name: obsolete abnormal orbital bone morphology
def: "OBSOLETE. structural anomaly of the bony cavity that contains the eyeball and is formed by parts of eight bones in the mouse: maxilla, lacrimal, zygomatic, frontal, temporal, sphenoid, ethmoid, palatine" [ISBN:0-683-40008-8]
synonym: "abnormal orbital bones" EXACT []
is_obsolete: true

[Term]
id: MP:0005553
name: increased circulating creatinine level
def: "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased creatinine level" BROAD []
is_a: MP:0005328 ! abnormal circulating creatinine level
is_a: MP:0009644 ! uremia
is_a: MP:0014530 ! increased circulating amino acid level

[Term]
id: MP:0005554
name: decreased circulating creatinine level
def: "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased creatinine level" BROAD []
synonym: "reduced circulating creatinine level" EXACT []
is_a: MP:0005328 ! abnormal circulating creatinine level
is_a: MP:0014531 ! decreased circulating amino acid level

[Term]
id: MP:0005556
name: abnormal renal filtration rate
def: "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [MGI:cwg]
synonym: "abnormal kidney clearance" EXACT []
synonym: "abnormal renal clearance" EXACT []
is_a: MP:0013285 ! abnormal renal filtration

[Term]
id: MP:0005557
name: increased creatinine clearance
def: "increased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded" [MGI:cwg, RGD:cur]
is_a: MP:0005556 ! abnormal renal filtration rate

[Term]
id: MP:0005558
name: decreased creatinine clearance
def: "decreased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded" [MGI:cwg, RGD:cur]
synonym: "reduced creatinine clearance" EXACT []
is_a: MP:0005556 ! abnormal renal filtration rate

[Term]
id: MP:0005559
name: increased circulating glucose level
def: "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [MGI:cwg, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased glucose level" BROAD []
is_a: MP:0000188 ! abnormal circulating glucose level

[Term]
id: MP:0005560
name: decreased circulating glucose level
def: "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [MGI:cwg, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased glucose level" BROAD []
synonym: "reduced circulating glucose level" EXACT []
is_a: MP:0000188 ! abnormal circulating glucose level

[Term]
id: MP:0005561
name: increased mean corpuscular hemoglobin
def: "greater than the average levels of hemoglobin contained in an erythrocyte" [ISBN:0-683-40008-8, RGD:cur]
comment: Mean corpuscular hemoglobin (MCH) is a standard measurement in clinical chemistry, usually reported in picograms/cell.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "high MCH" EXACT []
synonym: "high mean corpuscular haemoglobin" EXACT []
synonym: "high mean corpuscular hemoglobin" EXACT []
synonym: "hyperchromia" EXACT []
synonym: "increased MCH" EXACT []
synonym: "increased mean corpuscular haemoglobin" EXACT []
is_a: MP:0001589 ! abnormal mean corpuscular hemoglobin

[Term]
id: MP:0005562
name: decreased mean corpuscular hemoglobin
def: "less than the average levels of hemoglobin contained in an erythrocyte" [ISBN:0-683-40008-8, RGD:cur]
comment: Mean corpuscular hemoglobin (MCH) is a standard measurement in clinical chemistry, usually reported in picograms/cell.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased MCH" EXACT []
synonym: "decreased mean corpuscular haemoglobin" EXACT []
synonym: "hypochromasia" RELATED []
synonym: "hypochromatism" RELATED []
synonym: "hypochromia" RELATED []
synonym: "hypochromic erythrocyte" RELATED []
synonym: "hypochromic red cell" RELATED []
synonym: "hypochrosis" RELATED []
synonym: "low MCH" EXACT []
synonym: "low mean corpuscular haemoglobin" EXACT []
synonym: "low mean corpuscular hemoglobin" EXACT []
synonym: "reduced mean corpuscular haemoglobin" EXACT []
synonym: "reduced mean corpuscular hemoglobin" EXACT []
is_a: MP:0001589 ! abnormal mean corpuscular hemoglobin

[Term]
id: MP:0005563
name: abnormal hemoglobin content
def: "deviation from the normal total hemoglobin content in the circulating blood" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal haemoglobin content" EXACT []
is_a: MP:0001588 ! abnormal hemoglobin

[Term]
id: MP:0005564
name: increased hemoglobin content
def: "increase in the total hemoglobin content in the circulating blood" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased haemoglobin content" EXACT []
is_a: MP:0005563 ! abnormal hemoglobin content

[Term]
id: MP:0005565
name: increased blood urea nitrogen level
def: "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased BUN" EXACT []
is_a: MP:0005265 ! abnormal blood urea nitrogen level
is_a: MP:0009644 ! uremia

[Term]
id: MP:0005566
name: decreased blood urea nitrogen level
def: "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [ISBN:0-683-40008-8, RGD:cur]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased BUN" EXACT []
synonym: "reduced blood urea nitrogen level" EXACT []
synonym: "reduced BUN" EXACT []
is_a: MP:0005265 ! abnormal blood urea nitrogen level

[Term]
id: MP:0005567
name: decreased circulating total protein level
alt_id: MP:0005417
def: "total circulating protein level below the normal range" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased plasma total protein level" NARROW []
synonym: "decreased serum total protein level" NARROW []
synonym: "decreased total protein level" BROAD []
synonym: "hypoproteinemia" EXACT []
synonym: "reduced circulating total protein level" EXACT []
is_a: MP:0011888 ! abnormal circulating total protein level
is_a: MP:0014502 ! decreased circulating protein level

[Term]
id: MP:0005568
name: increased circulating total protein level
def: "total circulating protein level above the normal range" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyperproteinemia" EXACT []
synonym: "increased plasma total protein level" NARROW []
synonym: "increased serum total protein level" NARROW []
synonym: "increased total protein level" BROAD []
is_a: MP:0011888 ! abnormal circulating total protein level
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0005571
name: decreased lactate dehydrogenase level
def: "reduced level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate" [MeSH:D08.811.682.047.551.400]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased LDH level" EXACT []
synonym: "reduced lactate dehydrogenase level" EXACT []
synonym: "reduced LDH level" EXACT []
is_a: MP:0002943 ! abnormal lactate dehydrogenase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level

[Term]
id: MP:0005572
name: abnormal pulmonary respiratory rate
def: "deviation from the normal number of breaths per minute" [RGD:cur]
comment: Do not confuse with pulmonary ventilation (volume of air per minute vs. number of breaths per minute).
subset: Europhenome_Terms
subset: IMPC
synonym: "abnormal BF" EXACT []
synonym: "abnormal breathing frequency" EXACT []
synonym: "abnormal pulmonary ventilation rate" EXACT []
synonym: "abnormal respiration rate" EXACT []
synonym: "abnormal respiratory rate" EXACT []
synonym: "abnormal ventilation rate" EXACT []
is_a: MP:0001951 ! abnormal breathing pattern

[Term]
id: MP:0005573
name: increased pulmonary respiratory rate
def: "greater than the normal number of breaths per minute" [RGD:cur]
comment: Do not confuse with pulmonary ventilation (volume of air per minute vs. number of breaths per minute).
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased BF" EXACT []
synonym: "increased breathing frequency" EXACT []
synonym: "increased pulmonary ventilation rate" EXACT []
synonym: "increased respiration rate" EXACT []
synonym: "increased respiratory rate" EXACT []
synonym: "increased ventilation rate" EXACT []
is_a: MP:0005572 ! abnormal pulmonary respiratory rate

[Term]
id: MP:0005574
name: decreased pulmonary respiratory rate
def: "fewer than the normal number of breaths per minute" [RGD:cur]
comment: Do not confuse with pulmonary ventilation (volume of air per minute vs. number of breaths per minute).
subset: Europhenome_Terms
subset: IMPC
synonym: "bradypnea" EXACT []
synonym: "decreased BF" EXACT []
synonym: "decreased breathing frequency" EXACT []
synonym: "decreased pulmonary ventilation rate" EXACT []
synonym: "decreased respiration rate" EXACT []
synonym: "decreased respiratory rate" EXACT []
synonym: "decreased ventilation rate" EXACT []
synonym: "reduced BF" EXACT []
synonym: "reduced breathing frequency" EXACT []
synonym: "reduced pulmonary ventilation rate" EXACT []
synonym: "reduced respiration rate" EXACT []
synonym: "reduced respiratory rate" EXACT []
synonym: "reduced ventilation rate" EXACT []
is_a: MP:0005572 ! abnormal pulmonary respiratory rate

[Term]
id: MP:0005575
name: increased pulmonary ventilation
def: "increase in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment" [ISBN:0-683-40008-8, RGD:cur]
comment: Do not confuse with pulmonary ventilation rate (aka respiratory rate). Pulmonary ventilation is the volume of air per minute; pulmonary ventilation rate is the number of breaths per minute.
synonym: "increased respiratory minute ventilation" RELATED []
synonym: "increased respiratory minute volume" EXACT []
is_a: MP:0002338 ! abnormal pulmonary ventilation

[Term]
id: MP:0005576
name: decreased pulmonary ventilation
def: "reduction in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment" [http://www.dorlands.com/, RGD:cur]
comment: Do not confuse with pulmonary ventilation rate (aka respiratory rate). Pulmonary ventilation is the volume of air per minute; pulmonary ventilation rate is the number of breaths per minute.
synonym: "decreased respiratory minute ventilation" RELATED []
synonym: "decreased respiratory minute volume" EXACT []
synonym: "reduced pulmonary ventilation" EXACT []
synonym: "reduced respiratory minute volume" EXACT []
is_a: MP:0002338 ! abnormal pulmonary ventilation

[Term]
id: MP:0005577
name: uterus prolapse
def: "downward movement, and possible external appearance, of the uterus through the vagina" [https://orcid.org/0000-0002-0371-1954]
synonym: "metra prolapse" EXACT []
synonym: "metral prolapse" EXACT []
synonym: "uterine prolapse" RELATED []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0005578
name: teratozoospermia
def: "presence of structurally anomalous spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "teratospermia" EXACT []
is_a: MP:0001124 ! abnormal gametes
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0006362 ! abnormal male germ cell morphology

[Term]
id: MP:0005579
name: absent outer ear
def: "absence of the auricles or external acoustic meatus" [MGI:cwg]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0005580
name: periinsulitis
def: "an accumulation of macrophages, dendritic cells, and B and T lymphocytes in the periductal areas of the pancreas but outside the islet cell areas; often occurs prior to intra-insulitis of the islet cell areas" [http://www.diapedia.org]
synonym: "peri-insulitis" EXACT []
synonym: "periinsulinitis" EXACT []
is_a: MP:0001869 ! pancreas inflammation

[Term]
id: MP:0005581
name: abnormal renin activity
def: "altered ability of this enzyme to cleave angiotensionogen and create angiotensin I" [RGD:cur]
synonym: "abnormal angiotensionogenase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0005582
name: increased renin activity
def: "greater than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I" [RGD:cur]
synonym: "increased angiotensionogenase activity" EXACT []
is_a: MP:0005581 ! abnormal renin activity

[Term]
id: MP:0005583
name: decreased renin activity
def: "less than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I" [RGD:cur]
synonym: "decreased angiotensionogenase activity" EXACT []
synonym: "reduced angiotensionogenase activity" EXACT []
synonym: "reduced renin activity" EXACT []
is_a: MP:0005581 ! abnormal renin activity

[Term]
id: MP:0005584
name: abnormal enzyme/coenzyme activity
def: "altered ability of any enzyme or their cofactors, to act as catalysts to induce chemical changes in other substances" [ISBN:0-683-40008-8]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0005585
name: increased tidal volume
def: "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [MESH:G09.772.765.850.970.500.700, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0002313 ! abnormal tidal volume

[Term]
id: MP:0005586
name: decreased tidal volume
def: "less than the normal volume of air inspired or expired during each normal respiratory cycle" [MESH:G09.772.765.850.970.500.700, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
synonym: "reduced tidal volume" EXACT []
is_a: MP:0002313 ! abnormal tidal volume

[Term]
id: MP:0005587
name: abnormal Meckel's cartilage morphology
def: "any structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8]
synonym: "abnormal mandibular cartilage morphology" EXACT []
synonym: "abnormal Meckel cartilage morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
is_a: MP:0030464 ! abnormal cranial cartilage morphology

[Term]
id: MP:0005590
name: increased vasodilation
def: "greater than the expected or normal widening of the lumen of the blood vessels" [ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0001613 ! abnormal vasodilation

[Term]
id: MP:0005591
name: decreased vasodilation
def: "less than the expected or normal widening of the lumen of the blood vessels" [ISBN:0-683-40008-8, RGD:cur]
synonym: "reduced vasodilation" EXACT []
is_a: MP:0001613 ! abnormal vasodilation

[Term]
id: MP:0005592
name: abnormal vascular smooth muscle morphology
def: "any structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MGI:cwg]
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0005595
name: abnormal vascular smooth muscle physiology
def: "any functional anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:cur]
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0005596
name: increased susceptibility to type I hypersensitivity reaction
alt_id: MP:0001878
def: "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this type of hypersensitivity include hay fever, asthma, and anaphylaxis.
synonym: "decreased resistance to anaphylactic shock" EXACT []
synonym: "decreased resistance to anaphylaxis" EXACT []
synonym: "decreased resistance to immediate type hypersensitivity" EXACT []
synonym: "decreased resistance to type I hypersensitivity reaction" EXACT []
synonym: "increased susceptibility to allergic response" EXACT []
synonym: "increased susceptibility to anaphylactic shock" EXACT []
synonym: "increased susceptibility to anaphylaxis" EXACT []
synonym: "increased susceptibility to immediate type hypersensitivity" EXACT []
is_a: MP:0002531 ! abnormal type I hypersensitivity reaction
is_a: MP:0005088 ! increased acute inflammation

[Term]
id: MP:0005597
name: decreased susceptibility to type I hypersensitivity reaction
def: "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this type of hypersensitivity include hay fever, asthma, and anaphylaxis.
synonym: "decreased susceptibility to anaphylactic shock" EXACT []
synonym: "decreased susceptibility to anaphylaxis" EXACT []
synonym: "decreased susceptibility to immediate type hypersensitivity" EXACT []
synonym: "increased resistance to anaphylactic shock" EXACT []
synonym: "increased resistance to anaphylaxis" EXACT []
synonym: "increased resistance to immediate type hypersensitivity" EXACT []
synonym: "increased resistance to type I hypersensitivity reaction" EXACT []
synonym: "reduced susceptibility to type I hypersensitivity reaction" EXACT []
is_a: MP:0002531 ! abnormal type I hypersensitivity reaction
is_a: MP:0005087 ! decreased acute inflammation

[Term]
id: MP:0005598
name: decreased heart ventricle muscle contractility
def: "reduced ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [ISBN:0-683-40008-8, RGD:cur]
synonym: "decreased ventricle muscle contractility" EXACT []
synonym: "decreased ventricular ejection fraction volume" NARROW []
synonym: "impaired ventricle muscle contractility" EXACT []
synonym: "reduced ventricle muscle contractility" EXACT []
is_a: MP:0005140 ! decreased cardiac muscle contractility

[Term]
id: MP:0005599
name: increased cardiac muscle contractility
alt_id: MP:0002973
def: "greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased cardiac muscle contraction" EXACT []
synonym: "increased fractional shortening (FS)" NARROW []
synonym: "increased peak of aortic outflow velocity (PAV)" NARROW []
synonym: "increased velocity of circumferential fiber shortening (Vcfc)" NARROW []
synonym: "increased velocity of circumferential fibre shortening (Vcfc)" NARROW []
synonym: "increased ventricular ejection fraction volume" NARROW []
is_a: MP:0002972 ! abnormal cardiac muscle contractility

[Term]
id: MP:0005600
name: increased heart ventricle muscle contractility
def: "greater than the normal ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased ventricle muscle contractility" EXACT []
synonym: "increased ventricular ejection fraction volume" NARROW []
is_a: MP:0005599 ! increased cardiac muscle contractility

[Term]
id: MP:0005601
name: increased angiogenesis
def: "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:cur]
synonym: "enhanced angiogenesis" EXACT []
is_a: MP:0000260 ! abnormal angiogenesis

[Term]
id: MP:0005602
name: decreased angiogenesis
def: "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:cur]
synonym: "reduced angiogenesis" EXACT []
is_a: MP:0000260 ! abnormal angiogenesis

[Term]
id: MP:0005603
name: neuron hypertrophy
def: "increased size of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [ISBN:0-683-40008-8, RGD:cur]
synonym: "increased nerve cell size" EXACT []
synonym: "increased neuron size" EXACT []
synonym: "neuronal hypertrophy" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0005604
name: hyperekplexia
def: "disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory" [ISBN:0-683-40008-8, RGD:cur]
is_a: MP:0001486 ! abnormal startle reflex

[Term]
id: MP:0005605
name: increased bone mass
def: "an increase in the total amount of bone tissue contained in the skeleton" [MGI:cwg]
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0005606
name: increased bleeding time
def: "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [RGD:cur]
is_a: MP:0002551 ! abnormal blood coagulation

[Term]
id: MP:0005607
name: decreased bleeding time
def: "less than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [RGD:cur]
synonym: "reduced bleeding time" EXACT []
is_a: MP:0002551 ! abnormal blood coagulation

[Term]
id: MP:0005608
name: cardiac interstitial fibrosis
def: "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [ISBN:0-683-40008-8, RGD:cur]
synonym: "interstitial fibrosis of the heart" EXACT []
is_a: MP:0003141 ! cardiac fibrosis
is_a: MP:0013258 ! abnormal extracellular matrix morphology

[Term]
id: MP:0005609
name: abnormal circulating antidiuretic hormone level
def: "deviation from the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [MESH:D06.472.699.631.692.781, MGI:cwg, RGD:cur]
synonym: "abnormal circulating level of ADH" EXACT []
synonym: "abnormal circulating level of antidiuretic hormone" EXACT []
synonym: "abnormal circulating level of AVP" EXACT []
synonym: "abnormal circulating level of vasopressin" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005610
name: increased circulating antidiuretic hormone level
def: "greater than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [MESH:D06.472.699.631.692.781, MGI:cwg, RGD:cur]
synonym: "increased circulating level of ADH" EXACT []
synonym: "increased circulating level of antidiuretic hormone" EXACT []
synonym: "increased circulating level of AVP" EXACT []
synonym: "increased circulating level of vasopressin" EXACT []
is_a: MP:0005609 ! abnormal circulating antidiuretic hormone level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005611
name: decreased circulating antidiuretic hormone level
def: "less than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [MESH:D06.472.699.631.692.781, MGI:cwg, RGD:cur]
synonym: "decreased circulating level of ADH" EXACT []
synonym: "decreased circulating level of antidiuretic hormone" EXACT []
synonym: "decreased circulating level of AVP" EXACT []
synonym: "decreased circulating level of vasopressin" EXACT []
synonym: "reduced circulating antidiuretic hormone level" EXACT []
is_a: MP:0005609 ! abnormal circulating antidiuretic hormone level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005612
name: decreased susceptibility to type II hypersensitivity reaction
def: "less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigus, and pemphigoid.
synonym: "decreased susceptibility to antibody-mediated cellular toxicity" EXACT []
synonym: "decreased susceptibility to cytotoxic type hypersensitivity" EXACT []
synonym: "increased resistance to antibody-mediated cellular toxicity" EXACT []
synonym: "increased resistance to cytotoxic type hypersensitivity" EXACT []
synonym: "increased resistance to type II hypersensitivity reaction" EXACT []
synonym: "reduced susceptibility to type II hypersensitivity reaction" EXACT []
is_a: MP:0002532 ! abnormal type II hypersensitivity reaction
is_a: MP:0005087 ! decreased acute inflammation

[Term]
id: MP:0005613
name: increased susceptibility to type II hypersensitivity reaction
def: "greater likelihood or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigus, and pemphigoid.
synonym: "decreased resistance to antibody-mediated cellular toxicity" EXACT []
synonym: "decreased resistance to cytotoxic type hypersensitivity" EXACT []
synonym: "decreased resistance to type II hypersensitivity reaction" EXACT []
synonym: "increased susceptibility to antibody-mediated cellular toxicity" EXACT []
synonym: "increased susceptibility to cytotoxic type hypersensitivity" EXACT []
is_a: MP:0002532 ! abnormal type II hypersensitivity reaction
is_a: MP:0005088 ! increased acute inflammation

[Term]
id: MP:0005614
name: decreased susceptibility to type III hypersensitivity reaction
def: "less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: Autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome, scleroderma, and glomerulonephritis.
synonym: "decreased susceptibility to immune complex mediated hypersensitivity" EXACT []
synonym: "increased resistance to immune complex mediated hypersensitivity" EXACT []
synonym: "increased resistance to type III hypersensitivity reaction" EXACT []
synonym: "reduced susceptibility to type III hypersensitivity reaction" EXACT []
is_a: MP:0002533 ! abnormal type III hypersensitivity reaction
is_a: MP:0005087 ! decreased acute inflammation

[Term]
id: MP:0005615
name: increased susceptibility to type III hypersensitivity reaction
def: "greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: Autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome, scleroderma, and glomerulonephritis.
synonym: "decreased resistance to immune complex mediated hypersensitivity" EXACT []
synonym: "decreased resistance to type III hypersensitivity reaction" EXACT []
synonym: "increased susceptibility to immune complex mediated hypersensitivity" EXACT []
is_a: MP:0002533 ! abnormal type III hypersensitivity reaction
is_a: MP:0005088 ! increased acute inflammation

[Term]
id: MP:0005616
name: decreased susceptibility to type IV hypersensitivity reaction
def: "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: granulomatous diseases: tuberculosis, and sarcoidosis contact dermatitis: elicited by poison ivy, detergents, clothing, etc.
synonym: "decreased susceptibility to cell-mediated hypersensitivity" EXACT []
synonym: "decreased susceptibility to delayed type hypersensitivity" EXACT []
synonym: "increased resistance to cell-mediated hypersensitivity" EXACT []
synonym: "increased resistance to delayed type hypersensitivity" EXACT []
synonym: "increased resistance to type IV hypersensitivity reaction" EXACT []
synonym: "reduced susceptibility to type IV hypersensitivity reaction" EXACT []
is_a: MP:0002534 ! abnormal type IV hypersensitivity reaction
is_a: MP:0005087 ! decreased acute inflammation

[Term]
id: MP:0005617
name: increased susceptibility to type IV hypersensitivity reaction
def: "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [ISBN:0-397-51047-0, MGI:cwg]
comment: Examples of this include: granulomatous diseases: tuberculosis, and sarcoidosis contact dermatitis: elicited by poison ivy, detergents, clothing, etc.
synonym: "decreased resistance to cell-mediated hypersensitivity" EXACT []
synonym: "decreased resistance to delayed type hypersensitivity" EXACT []
synonym: "decreased resistance to type IV hypersensitivity reaction" EXACT []
synonym: "increased susceptibility to cell-mediated hypersensitivity" EXACT []
synonym: "increased susceptibility to delayed type hypersensitivity" EXACT []
is_a: MP:0002534 ! abnormal type IV hypersensitivity reaction
is_a: MP:0005088 ! increased acute inflammation

[Term]
id: MP:0005618
name: decreased urine potassium level
alt_id: MP:0006314
def: "less than the normal amount of potassium in the urine" [https://orcid.org/0000-0003-3691-0324, RGD:cur]
synonym: "decreased potassium excretion" EXACT []
synonym: "reduced potassium excretion" EXACT []
synonym: "reduced urine potassium level" EXACT []
is_a: MP:0004820 ! abnormal urine potassium level

[Term]
id: MP:0005619
name: increased urine potassium level
alt_id: MP:0006313
def: "greater than normal amount of potassium in the urine" [RGD:cur]
synonym: "increased potassium excretion" EXACT []
is_a: MP:0004820 ! abnormal urine potassium level

[Term]
id: MP:0005620
name: abnormal muscle contractility
def: "aberrant ability of a muscle to shorten or to develop increased tension" [ISBN:0-683-40008-8]
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0005621
name: abnormal cell physiology
def: "any functional anomaly of the vital processes of the cell" [ISBN:0-683-40008-8, MGI:hdene]
is_a: MP:0005384 ! cellular phenotype

[Term]
id: MP:0005623
name: abnormal meninges morphology
def: "any structural anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0005624
name: abnormal plasma anion gap
def: "measurement of the interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate" [RGD:cur]
is_a: MP:0001765 ! abnormal ion homeostasis

[Term]
id: MP:0005625
name: increased plasma anion gap
def: "greater than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; high anion gap is indicative of metabolic acidosis" [RGD:cur]
synonym: "high anion gap" EXACT []
is_a: MP:0005624 ! abnormal plasma anion gap

[Term]
id: MP:0005626
name: decreased plasma anion gap
def: "less than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins, as in multiple myeloma" [RGD:cur]
synonym: "low anion gap" EXACT []
synonym: "reduced plasma anion gap" EXACT []
is_a: MP:0005624 ! abnormal plasma anion gap

[Term]
id: MP:0005627
name: increased circulating potassium level
def: "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased blood potassium level" EXACT []
is_a: MP:0002668 ! abnormal circulating potassium level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0005628
name: decreased circulating potassium level
def: "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased blood potassium level" EXACT []
synonym: "reduced circulating potassium level" EXACT []
is_a: MP:0002668 ! abnormal circulating potassium level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0005629
name: abnormal lung weight
def: "anomaly in the average weight of the lung" [RGD:cur]
is_a: MP:0004881 ! abnormal lung size

[Term]
id: MP:0005630
name: increased lung weight
def: "greater than average weight of the lung" [RGD:cur]
is_a: MP:0004882 ! enlarged lung
is_a: MP:0005629 ! abnormal lung weight

[Term]
id: MP:0005631
name: decreased lung weight
def: "reduced average weight of the lung" [RGD:cur]
synonym: "reduced lung weight" EXACT []
is_a: MP:0003641 ! small lung
is_a: MP:0005629 ! abnormal lung weight

[Term]
id: MP:0005632
name: decreased circulating aspartate transaminase level
def: "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased AST level" BROAD []
synonym: "decreased circulating AAT level" EXACT []
synonym: "decreased circulating ASAT level" EXACT []
synonym: "decreased circulating aspartate aminotransferase level" EXACT []
synonym: "decreased circulating serum glutamic oxaloacetic transaminase level" EXACT []
synonym: "decreased circulating SGOT level" EXACT []
synonym: "reduced AST level" BROAD []
synonym: "reduced circulating AAT level" EXACT []
synonym: "reduced circulating ASAT level" EXACT []
synonym: "reduced circulating aspartate aminotransferase level" EXACT []
synonym: "reduced circulating aspartate transaminase level" EXACT []
synonym: "reduced circulating serum glutamic oxaloacetic transaminase level" EXACT []
synonym: "reduced circulating SGOT level" EXACT []
is_a: MP:0000203 ! abnormal circulating aspartate transaminase level
is_a: MP:0014451 ! decreased circulating enzyme level

[Term]
id: MP:0005633
name: increased circulating sodium level
def: "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypernatraemia" EXACT []
synonym: "hypernatremia" EXACT []
is_a: MP:0001776 ! abnormal circulating sodium level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0005634
name: decreased circulating sodium level
def: "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyponatraemia" EXACT []
synonym: "hyponatremia" EXACT []
synonym: "reduced circulating sodium level" EXACT []
is_a: MP:0001776 ! abnormal circulating sodium level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0005635
name: decreased circulating bilirubin level
def: "reduced concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, RGD:cur]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hypobilirubinaemia" EXACT []
synonym: "hypobilirubinemia" EXACT []
synonym: "reduced circulating bilirubin level" EXACT []
is_a: MP:0001569 ! abnormal circulating bilirubin level

[Term]
id: MP:0005636
name: abnormal mineral homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of inorganic substances that have importance in body functions" [ISBN:0-683-40008-8, MGI:cwg]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0005637
name: abnormal iron homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of iron that normally is a cofactor in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [ISBN:0-683-40008-8]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0005636 ! abnormal mineral homeostasis

[Term]
id: MP:0005638
name: hemochromatosis
def: "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MESH:C16.320.565.618.337]
synonym: "haemochromatosis" EXACT []
is_a: MP:0014541 ! increased iron level

[Term]
id: MP:0005639
name: hemosiderosis
def: "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MESH:C18.452.565.500.500]
synonym: "haemosiderosis" EXACT []
is_a: MP:0014541 ! increased iron level

[Term]
id: MP:0005640
name: abnormal mean corpuscular hemoglobin concentration
def: "deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [ISBN:0-683-40008-8]
comment: Mean corpuscular hemoglobin concentration (MCHC) is a standard measurement in clinical chemistry, usually reported in g/L or g/dL.
synonym: "abnormal MCHC" EXACT []
synonym: "abnormal mean corpuscular haemoglobin concentration" EXACT []
is_a: MP:0001588 ! abnormal hemoglobin

[Term]
id: MP:0005641
name: increased mean corpuscular hemoglobin concentration
def: "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [ISBN:0-683-40008-8]
comment: Mean corpuscular hemoglobin concentration (MCHC) is a standard measurement in clinical chemistry, usually reported in g/L or g/dL.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "high MCHC" EXACT []
synonym: "high mean corpuscular haemoglobin concentration" EXACT []
synonym: "high mean corpuscular hemoglobin concentration" EXACT []
synonym: "increased MCHC" EXACT []
synonym: "increased mean corpuscular haemoglobin concentration" EXACT []
is_a: MP:0005640 ! abnormal mean corpuscular hemoglobin concentration

[Term]
id: MP:0005642
name: decreased mean corpuscular hemoglobin concentration
def: "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [ISBN:0-683-40008-8]
comment: Mean corpuscular hemoglobin concentration (MCHC) is a standard measurement in clinical chemistry, usually reported in g/L or g/dL.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased MCHC" EXACT []
synonym: "decreased mean corpuscular haemoglobin concentration" EXACT []
synonym: "low MCHC" EXACT []
synonym: "low mean corpuscular haemoglobin concentration" EXACT []
synonym: "low mean corpuscular hemoglobin concentration" EXACT []
synonym: "reduced mean corpuscular haemoglobin concentration" EXACT []
synonym: "reduced mean corpuscular hemoglobin concentration" EXACT []
is_a: MP:0005640 ! abnormal mean corpuscular hemoglobin concentration

[Term]
id: MP:0005643
name: decreased dopamine level
def: "less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MESH:D02.092.211.215.311.342]
synonym: "reduced dopamine level" EXACT []
is_a: MP:0001905 ! abnormal dopamine level

[Term]
id: MP:0005644
name: agonadal
def: "denoting the absence of gonads" [MGI:llw2]
is_a: MP:0000654 ! absent sex gland
is_a: MP:0002211 ! abnormal primary sex determination

[Term]
id: MP:0005645
name: abnormal hypothalamus physiology
def: "any functional anomaly of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [ISBN:0-683-40008-8]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0005646
name: abnormal pituitary gland physiology
def: "any functional anomaly of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [ISBN:0-683-40008-8]
synonym: "abnormal pituitary physiology" RELATED []
is_a: MP:0013570 ! abnormal neuroendocrine gland physiology

[Term]
id: MP:0005647
name: abnormal sex gland physiology
def: "any functional anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [MGI:cwg]
synonym: "abnormal genitalia gland physiology" EXACT []
synonym: "abnormal gland of genitalia physiology" EXACT []
synonym: "abnormal reproductive gland physiology" EXACT []
synonym: "abnormal reproductive system gland physiology" EXACT []
synonym: "abnormal sex gland function" EXACT []
is_a: MP:0001919 ! abnormal reproductive system physiology
is_a: MP:0002164 ! abnormal gland physiology

[Term]
id: MP:0005648
name: heart right ventricle degeneration
def: "replacement of cardiomyocytes in the right ventricle with fibrous tissue and/or fat" [https://orcid.org/0000-0003-4606-0597]
synonym: "heart right ventricular degeneration" RELATED []
synonym: "right ventricle degeneration" EXACT []
synonym: "right ventricular degeneration" EXACT []
is_a: MP:0003920 ! abnormal heart right ventricle morphology

[Term]
id: MP:0005649
name: increased spleen neoplasm incidence
def: "greater than the expected number of a neoplasm of the spleen, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "neoplastic spleen" RELATED []
synonym: "spleen neoplasia" RELATED []
synonym: "spleen neoplasm" RELATED []
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence

[Term]
id: MP:0005650
name: abnormal limb bud morphology
def: "any structural anomaly of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:A16.567, MGI:hdene]
subset: IMPC_Prenatal
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0006279 ! abnormal limb development

[Term]
id: MP:0005651
name: abnormal gonad rudiment morphology
def: "any structural anomaly of the undifferentiated mesoderm that gives rise to the gonads" [MGI:llw2]
synonym: "abnormal gonad mesenchyme" EXACT []
is_a: MP:0003936 ! abnormal reproductive system development

[Term]
id: MP:0005652
name: sex reversal
def: "development of the reproductive system is inconsistent with the chromosomal sex" [MGI:llw2]
is_a: MP:0002210 ! abnormal sex determination

[Term]
id: MP:0005653
name: phototoxicity
def: "condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0001764 ! abnormal homeostasis
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0005654
name: porphyria
def: "acquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if acquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites" [https://orcid.org/0000-0002-6490-7723, MESH:C16.320.565.708]
is_a: MP:0004147 ! increased porphyrin level

[Term]
id: MP:0005655
name: increased aggression
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assault posture and/or hostile physical action" [ISBN:0-683-40008-8, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002061 ! abnormal aggression-related behavior

[Term]
id: MP:0005656
name: decreased aggression
def: "when compared to controls, subjects exhibit less than the normal level of domineering, assault posture and/or hostile physical action" [ISBN:0-683-40008-8, MGI:cwg]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced aggression" EXACT []
is_a: MP:0002061 ! abnormal aggression-related behavior

[Term]
id: MP:0005657
name: abnormal neural plate morphology
def: "any structural anomaly of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest" [ISBN:0-683-40008-8, MGI:hdene]
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0003861 ! abnormal nervous system development

[Term]
id: MP:0005658
name: increased susceptibility to diet-induced obesity
def: "more likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat" [MGI:cwg]
synonym: "decreased resistance to diet-induced obesity" EXACT []
is_a: MP:0004890 ! decreased energy expenditure
is_a: MP:0005455 ! increased susceptibility to weight gain

[Term]
id: MP:0005659
name: decreased susceptibility to diet-induced obesity
def: "less likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat" [MGI:cwg]
synonym: "increased resistance to diet-induced obesity" EXACT []
is_a: MP:0004889 ! increased energy expenditure
is_a: MP:0010182 ! decreased susceptibility to weight gain

[Term]
id: MP:0005660
name: abnormal circulating adrenaline level
def: "aberrant concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-0371-1954, MESH:D02.033.100.291.310]
is_a: MP:0003962 ! abnormal adrenaline level
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005661
name: decreased circulating adrenaline level
def: "less than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-0371-1954, MESH:D02.033.100.291.310]
synonym: "decreased circulating epinephrine level" EXACT []
synonym: "reduced circulating adrenaline level" EXACT []
is_a: MP:0005660 ! abnormal circulating adrenaline level
is_a: MP:0014457 ! decreased circulating hormone level
is_a: MP:0030762 ! decreased adrenaline level

[Term]
id: MP:0005662
name: increased circulating adrenaline level
def: "greater than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-0371-1954, MESH:D02.033.100.291.310]
synonym: "increased circulating epinephrine level" EXACT []
is_a: MP:0005660 ! abnormal circulating adrenaline level
is_a: MP:0014456 ! increased circulating hormone level
is_a: MP:0030761 ! increased adrenaline level

[Term]
id: MP:0005663
name: abnormal circulating noradrenaline level
def: "aberrant blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [ISBN:0198506732]
synonym: "abnormal circulating norepinephrine level" EXACT []
is_a: MP:0003964 ! abnormal noradrenaline level
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005664
name: decreased circulating noradrenaline level
def: "less than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [ISBN:0198506732]
synonym: "decreased circulating norepinephrine level" EXACT []
synonym: "reduced circulating noradrenaline level" EXACT []
is_a: MP:0005663 ! abnormal circulating noradrenaline level
is_a: MP:0012574 ! decreased noradrenaline level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005665
name: increased circulating noradrenaline level
def: "greater than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [ISBN:0198506732]
synonym: "increased circulating norepinephrine level" EXACT []
is_a: MP:0005663 ! abnormal circulating noradrenaline level
is_a: MP:0012575 ! increased noradrenaline level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005666
name: abnormal adipose tissue physiology
def: "any functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:cwg]
is_a: MP:0005375 ! adipose tissue phenotype

[Term]
id: MP:0005667
name: abnormal circulating leptin level
def: "anomaly in the blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MESH:D06.472.699.042.500]
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0005668
name: decreased circulating leptin level
def: "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MESH:D06.472.699.042.500]
synonym: "hypoleptinaemia" EXACT []
synonym: "hypoleptinemia" EXACT []
synonym: "reduced circulating leptin level" EXACT []
is_a: MP:0005667 ! abnormal circulating leptin level
is_a: MP:0014457 ! decreased circulating hormone level

[Term]
id: MP:0005669
name: increased circulating leptin level
def: "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MESH:D06.472.699.042.500]
synonym: "hyperleptinaemia" EXACT []
synonym: "hyperleptinemia" NARROW []
is_a: MP:0005667 ! abnormal circulating leptin level
is_a: MP:0014456 ! increased circulating hormone level

[Term]
id: MP:0005670
name: abnormal white adipose tissue physiology
def: "any functional anomaly in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [ISBN:0-683-40008-8]
synonym: "abnormal white fat physiology" RELATED []
is_a: MP:0005666 ! abnormal adipose tissue physiology

[Term]
id: MP:0005671
name: abnormal response to transplant
def: "anomaly in the body's reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MESH:E07.945, MGI:cwg]
synonym: "abnormal response to cell transplant" EXACT []
synonym: "abnormal response to organ graft" EXACT []
synonym: "abnormal response to tissue graft" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology

[Term]
id: MP:0005672
name: increased susceptibility to graft versus host disease
def: "greater likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MESH:C20.452, MGI:cwg]
synonym: "decreased resistance to graft versus host disease" EXACT []
synonym: "decreased resistance to graft vs host disease" EXACT []
synonym: "decreased resistance to GVHD" EXACT []
synonym: "increased susceptibility to graft vs host disease" EXACT []
synonym: "increased susceptibility to GVHD" EXACT []
is_a: MP:0005671 ! abnormal response to transplant

[Term]
id: MP:0005673
name: decreased susceptibility to graft versus host disease
def: "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MESH:C20.452, MGI:cwg]
synonym: "decreased susceptibility to graft vs host disease" EXACT []
synonym: "decreased susceptibility to GVHD" EXACT []
synonym: "increased resistance to graft versus host disease" EXACT []
synonym: "increased resistance to graft vs host disease" EXACT []
synonym: "increased resistance to GVHD" EXACT []
synonym: "reduced susceptibility to graft versus host disease" EXACT []
is_a: MP:0005671 ! abnormal response to transplant

[Term]
id: MP:0005675
name: small gallbladder
def: "reduced size of the gall bladder, the organ that serves as a storage reservoir for bile" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased gallbladder size" EXACT []
synonym: "small cholecyst" EXACT []
synonym: "small gall bladder" EXACT []
is_a: MP:0020134 ! abnormal gallbladder size

[Term]
id: MP:0006000
name: abnormal cornea epithelium morphology
def: "any structural anomaly of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597, MESH:A09.371.060.217.325]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal corneal epithelium morphology" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
is_a: MP:0013754 ! abnormal ocular surface morphology

[Term]
id: MP:0006001
name: abnormal intestinal transit time
def: "any anomaly in the time it takes for a bolus of material to pass through the intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011082 ! abnormal gastrointestinal motility

[Term]
id: MP:0006002
name: abnormal small intestinal transit time
def: "increase or decrease in the time it takes for a bolus of material to pass through the small intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006001 ! abnormal intestinal transit time

[Term]
id: MP:0006003
name: abnormal large intestinal transit time
def: "any anomaly in the time it takes for a bolus of material to pass through the large intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006001 ! abnormal intestinal transit time

[Term]
id: MP:0006004
name: obsolete abnormal interneuron morphology
def: "OBSOLETE. any structural anomaly of neurons that exclusively interact with other neurons" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true

[Term]
id: MP:0006005
name: obsolete decreased interneuron number
def: "OBSOLETE. fewer than normal number of neurons that interact only with other neurons" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced interneuron number" EXACT []
is_obsolete: true

[Term]
id: MP:0006006
name: increased sensory neuron number
def: "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0008947 ! increased neuron number

[Term]
id: MP:0006007
name: abnormal basal ganglion morphology
def: "any structural anomaly of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal basal ganglia morphology" EXACT []
is_a: MP:0000783 ! abnormal forebrain morphology

[Term]
id: MP:0006009
name: abnormal neuronal migration
def: "any anomaly in the movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [http://purl.obolibrary.org/obo/GO_0001764, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0004811 ! abnormal neuron physiology

[Term]
id: MP:0006010
name: absent strial intermediate cells
def: "absence of the melanocytes (i.e. crest-derived intermediate cells) normally located within the intrastrial space; loss of strial intermediate cells is known to lead to loss of the endocochlear potential" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cochlear melanocyte" EXACT []
synonym: "absent stria vascularis melanocytes" EXACT []
synonym: "absent strial melanocytes" EXACT []
is_a: MP:0004367 ! abnormal strial intermediate cell morphology

[Term]
id: MP:0006011
name: abnormal endolymphatic duct morphology
def: "any structural anomaly of the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal ductus endolymphaticus morphology" EXACT []
is_a: MP:0004427 ! abnormal vestibular labyrinth morphology

[Term]
id: MP:0006012
name: dilated endolymphatic duct
def: "stretched or widened aperture of the luminal space of the endolymphatic duct" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11152663]
synonym: "dilated endolymphatic ducts" EXACT []
synonym: "endolymphatic duct dilation" EXACT []
synonym: "inner ear hydrops" EXACT []
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0006013
name: absent endolymphatic sac
def: "absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:1346922]
synonym: "absent Bottcher space" EXACT []
synonym: "absent Cotunnius space" EXACT []
synonym: "absent sacculus endolymphaticus" EXACT []
synonym: "absent saccus endolymphaticu" EXACT []
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0006014
name: dilated endolymphatic sac
def: "stretched or widened aperture of the luminal space of the endolymphatic sac" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11152663]
synonym: "dilated endolymphatic sacs" EXACT []
synonym: "endolymphatic sac dilation" EXACT []
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0006015
name: dilated lateral semicircular canal
def: "stretched or widened aperture of the luminal space of the lateral semicircular canal" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "dilated horizontal semicircular canal" EXACT []
synonym: "dilated horizontal semicircular canals" EXACT []
synonym: "dilated lateral semicircular canals" EXACT []
synonym: "horizontal semicircular canal dilation" EXACT []
synonym: "lateral semicircular canal dilation" EXACT []
is_a: MP:0000037 ! abnormal lateral semicircular canal morphology

[Term]
id: MP:0006016
name: dilated posterior semicircular canal
def: "stretched or widened aperture of the luminal space of the posterior semicircular canal" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11152663]
synonym: "dilated posterior semicircular canals" EXACT []
synonym: "posterior semicircular canal dilation" EXACT []
is_a: MP:0002858 ! abnormal posterior semicircular canal morphology

[Term]
id: MP:0006017
name: dilated superior semicircular canal
def: "stretched or widened aperture of the luminal space of one or both of the superior semicircular canals" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11152663]
synonym: "anterior semicircular canal dilation" EXACT []
synonym: "dilated anterior semicircular canal" EXACT []
synonym: "dilated anterior semicircular canals" EXACT []
synonym: "dilated superior semicircular canals" EXACT []
synonym: "superior semicircular canal dilation" EXACT []
is_a: MP:0003069 ! abnormal superior semicircular canal morphology

[Term]
id: MP:0006018
name: abnormal tympanic membrane morphology
def: "any structural anomaly of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal drum membrane morphology" EXACT []
synonym: "abnormal eardrum morphology" RELATED []
synonym: "abnormal membrana tympani morphology" EXACT []
synonym: "abnormal myringa morphology" EXACT []
synonym: "abnormal myrinx morphology" EXACT []
is_a: MP:0000049 ! abnormal middle ear morphology

[Term]
id: MP:0006019
name: absent tympanic membrane
def: "absence of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "absent eardrum" RELATED []
is_a: MP:0006018 ! abnormal tympanic membrane morphology

[Term]
id: MP:0006020
name: decreased tympanic ring size
def: "smaller than average tympanic ring" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "decreased size of tympanic ring" EXACT []
synonym: "reduced size of tympanic ring" EXACT []
is_a: MP:0000030 ! abnormal tympanic ring morphology

[Term]
id: MP:0006021
name: abnormal Reissner membrane morphology
def: "any structural anomaly of the membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal membrana vestibularis ductus cochlearis morphology" EXACT []
synonym: "abnormal paries vestibularis ductus cochlearis morphology" EXACT []
synonym: "abnormal Reissner's membrane morphology" EXACT []
synonym: "abnormal vestibular membrane morphology" EXACT []
synonym: "abnormal vestibular wall of cochlear duct morphology" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology

[Term]
id: MP:0006022
name: absent Reissner membrane
def: "loss of the membrane which separates the cochlear duct from the vestibular canal" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "absent Reissner's membrane" EXACT []
is_a: MP:0006021 ! abnormal Reissner membrane morphology

[Term]
id: MP:0006023
name: detached Reissner membrane
def: "partial or complete loss of connection between the membrane and the stria vascularis, the periosteum covering the lamina spiralis ossea, or both" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "detached Reissner's membrane" EXACT []
is_a: MP:0006021 ! abnormal Reissner membrane morphology

[Term]
id: MP:0006024
name: collapsed Reissner membrane
def: "the Reissner's membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "collapsed Reissner's membrane" EXACT []
is_a: MP:0006021 ! abnormal Reissner membrane morphology

[Term]
id: MP:0006025
name: distended Reissner membrane
def: "an increase in the volume of endolymphatic fluid that results in distortion of the vestibular membrane" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "distended Reissner's membrane" EXACT []
is_a: MP:0006021 ! abnormal Reissner membrane morphology

[Term]
id: MP:0006026
name: dilated terminal bronchiole tube
def: "stretched or widened aperture of the luminal space of one or more of the terminal bronchiole tubes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:14499643]
synonym: "dilated terminal bronchiole tubes" EXACT []
synonym: "dilated terminal lung bud" EXACT []
synonym: "dilated terminal lung buds" EXACT []
synonym: "terminal bronchiole tube dilation" EXACT []
is_a: MP:0002268 ! abnormal terminal bronchiole morphology

[Term]
id: MP:0006027
name: impaired lung alveolus development
def: "a block or reduction in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]
synonym: "impaired alveolarization" EXACT []
synonym: "impaired respiratory alveologenesis" EXACT []
synonym: "reduced alveolar formation" EXACT []
synonym: "reduced alveolarization" EXACT []
is_a: MP:0010995 ! abnormal lung alveolus development

[Term]
id: MP:0006028
name: obsolete impaired bronchiole branching
def: "OBSOLETE. a block or reduction in the morphogenesis of the bronchioles" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
comment: Instead use abnormal branching involved in lung morphogenesis MP:0011024 and children of this term.
synonym: "reduced bronchiole branching" EXACT []
is_obsolete: true
consider: MP:0011024

[Term]
id: MP:0006029
name: abnormal sclerotome morphology
def: "any structural anomaly of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord; normally, sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0006030
name: abnormal otic vesicle development
def: "anomaly in the formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [https://orcid.org/0000-0003-4606-0597, PMID:10471511]
synonym: "abnormal acoustic vesicle development" EXACT []
synonym: "abnormal acoustic vesicle formation" EXACT []
synonym: "abnormal auditory vesicle development" EXACT []
synonym: "abnormal auditory vesicle formation" EXACT []
synonym: "abnormal otic vesicle formation" EXACT []
synonym: "abnormal otocyst formation" EXACT []
is_a: MP:0009806 ! abnormal otic vesicle morphology

[Term]
id: MP:0006031
name: abnormal pharyngeal pouch morphology
def: "any structural anomaly of the balloonlike diverticulae of the embryonic pharyngeal endoderm that line the inside of the branchial arches; these paired endodermal evaginations develop in a craniocaudal sequence between the branchial arches, e.g. pouch 1 lies between arches 1 and 2; in mammals, there are four well-developed pairs of pouches (the fifth and sixth pair is vestigial or absent); the pouch endoderm reaches the branchial groove ectoderm to form the double-layer branchial membranes that separate them" [http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-50-the-pharyngeal-clefts-and-pouches, https://www.inkling.com/read/before-we-are-born-moore-persaud-torchia-8th/chapter-10/pharyngeal-pouches, PMID:20144910]
synonym: "abnormal branchial pouch morphology" EXACT []
synonym: "abnormal endodermal pouch morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0006032
name: abnormal ureteric bud morphology
def: "any structural anomaly of the epithelial swelling on the metanephric duct that elongates to invade the adjacent metanephric mesenchyme; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [PMID:19828308]
synonym: "abnormal mesonephric diverticulum morphology" EXACT []
synonym: "abnormal UB morphology" EXACT []
is_a: MP:0003942 ! abnormal urinary system development

[Term]
id: MP:0006033
name: abnormal external auditory canal morphology
def: "any structural anomaly of the canal that connects the outer and middle ear" [https://orcid.org/0000-0003-4606-0597, PMID:10471511]
synonym: "abnormal external meatus" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0006034
name: myoglobinuria
def: "presence of myoglobin in the urine" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "increased urine myoglobin level" EXACT []
is_a: MP:0002962 ! increased urine protein level

[Term]
id: MP:0006035
name: abnormal mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles that occur in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells; mitochondria are notably the site of tissue respiration" [GO:0005739]
synonym: "abnormal mitochondria morphology" EXACT []
synonym: "abnormal mitochondrion morphology" EXACT []
is_a: MP:0014239 ! abnormal intracellular organelle morphology

[Term]
id: MP:0006036
name: abnormal mitochondrial physiology
def: "any functional anomaly of the cellular organelles responsible for energy production" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0006037
name: abnormal mitochondrial fission
def: "anomaly in the expansion rate of the cellular organelles responsible for energy production by division" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mitochondrial proliferation" EXACT []
is_a: MP:0020423 ! abnormal mitochondrial biogenesis

[Term]
id: MP:0006038
name: increased mitochondrial fission
def: "increase in the expansion rate of the cellular organelles responsible for energy production by division" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased mitochondrial proliferation" EXACT []
is_a: MP:0006037 ! abnormal mitochondrial fission

[Term]
id: MP:0006039
name: decreased mitochondrial fission
def: "reduction in the expansion rate of the cellular organelles responsible for energy production by division" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased mitochondrial proliferation" EXACT []
synonym: "reduced mitochondrial fission" EXACT []
synonym: "reduced mitochondrial proliferation" EXACT []
is_a: MP:0006037 ! abnormal mitochondrial fission

[Term]
id: MP:0006040
name: obsolete increased mitochondrial oxidation
def: "OBSOLETE. greater than normal activity of the process in mitochondria that produces ATP" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased oxidative phosphorylation" EXACT []
is_obsolete: true
consider: MP:0010951
consider: MP:0010954
consider: MP:0010959

[Term]
id: MP:0006041
name: obsolete decreased mitochondrial oxidation
def: "OBSOLETE. less than normal activity of the mitochondrial process that produces ATP" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_obsolete: true
consider: MP:0010951
consider: MP:0010954
consider: MP:0010959

[Term]
id: MP:0006042
name: increased apoptosis
def: "greater than normal programmed cell death" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0012556 ! increased cell death

[Term]
id: MP:0006043
name: decreased apoptosis
def: "less than normal cell death" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "reduced apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0012555 ! decreased cell death

[Term]
id: MP:0006044
name: tricuspid valve regurgitation
def: "the backward reflux of blood through the tricuspid valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
subset: CvDC_Terms
synonym: "right atrioventricular valve insufficiency" EXACT []
synonym: "right atrioventricular valve regurgitation" EXACT []
synonym: "right AV valve insufficiency" EXACT []
synonym: "right AV valve regurgitation" EXACT []
synonym: "tricuspid regurgitation" EXACT []
synonym: "tricuspid valve insufficiency" EXACT []
xref: Fyler:1161
is_a: MP:0006046 ! atrioventricular valve regurgitation
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006045
name: mitral valve regurgitation
def: "the backward reflux of blood through the mitral valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
subset: CvDC_Terms
synonym: "bicuspid valve insufficiency" EXACT []
synonym: "left atrioventricular valve insufficiency" EXACT []
synonym: "left atrioventricular valve regurgitation" EXACT []
synonym: "left AV valve insufficiency" EXACT []
synonym: "left AV valve regurgitation" EXACT []
synonym: "mitral regurgitation" EXACT []
synonym: "mitral valve insufficiency" EXACT []
xref: Fyler:1151
is_a: MP:0006046 ! atrioventricular valve regurgitation
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006046
name: atrioventricular valve regurgitation
def: "the backward reflux of blood through the atrioventricular valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
subset: CvDC_Terms
synonym: "atrioventricular valve insufficiency" EXACT []
synonym: "AV valve insufficiency" EXACT []
synonym: "AV valve regurgitation" EXACT []
synonym: "AVSD AV valvar regurgitation" EXACT []
is_a: MP:0009384 ! cardiac valve regurgitation

[Term]
id: MP:0006047
name: aortic valve regurgitation
def: "the backward reflux of blood through the aortic valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
subset: CvDC_Terms
synonym: "aortic regurgitation" EXACT []
synonym: "aortic semi-lunar valve regurgitation" EXACT []
synonym: "aortic semilunar valve regurgitation" EXACT []
synonym: "aortic valve insufficiency" EXACT []
synonym: "left arterial valve regurgitation" EXACT []
synonym: "left semi-lunar valve regurgitation" EXACT []
synonym: "left semilunar valve regurgitation" EXACT []
synonym: "left ventriculoarterial junction regurgitation" EXACT []
is_a: MP:0006049 ! semilunar valve regurgitation

[Term]
id: MP:0006048
name: pulmonary valve regurgitation
def: "the backward reflux of blood through the pulmonary valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
subset: CvDC_Terms
synonym: "pulmonary regurgitation" EXACT []
synonym: "pulmonary valve insufficiency" EXACT []
synonym: "pulmonic valve regurgitation" EXACT []
synonym: "right arterial valve regurgitation" EXACT []
synonym: "right semi-lunar valve regurgitation" EXACT []
synonym: "right semilunar valve regurgitation" EXACT []
is_a: MP:0006049 ! semilunar valve regurgitation
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006049
name: semilunar valve regurgitation
def: "the backward reflux of blood through the semilunar valve(s), due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-4606-0597]
synonym: "outflow tract regurgitation" RELATED []
synonym: "semi-lunar valve insufficiency" EXACT []
synonym: "semi-lunar valve regurgitation" EXACT []
synonym: "semilunar valve insufficiency" EXACT []
is_a: MP:0009384 ! cardiac valve regurgitation

[Term]
id: MP:0006050
name: pulmonary fibrosis
def: "formation of fibrous tissue within the lung often resulting from inflammation or injury" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "lung fibrosis" EXACT []
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0006051
name: brainstem hemorrhage
def: "bleeding into the brain stem" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "brain stem bleeding" EXACT []
synonym: "brain stem haemorrhage" EXACT []
synonym: "brain stem hemorrhage" EXACT []
synonym: "brainstem haemorrhage" EXACT []
is_a: MP:0001915 ! intracranial hemorrhage

[Term]
id: MP:0006052
name: cerebellum hemorrhage
def: "bleeding into the cerebellum" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "cerebellum bleeding" EXACT []
synonym: "cerebellum haemorrhage" EXACT []
is_a: MP:0001915 ! intracranial hemorrhage

[Term]
id: MP:0006053
name: hypothalamus hemorrhage
def: "bleeding into the hypothalamus" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "hypothalamic bleeding" EXACT []
synonym: "hypothalamus haemorrhage" EXACT []
is_a: MP:0001915 ! intracranial hemorrhage

[Term]
id: MP:0006054
name: spinal hemorrhage
def: "bleeding into the spine" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "spinal bleeding" EXACT []
synonym: "spinal cord haemorrhage" EXACT []
synonym: "spinal cord hemorrhage" EXACT []
synonym: "spinal haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0006055
name: abnormal vascular endothelial cell morphology
def: "any structural anomaly of the cells that line the vasculature" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal vascular endothelium" EXACT []
is_a: MP:0009489 ! abnormal blood vessel endothelium morphology

[Term]
id: MP:0006056
name: increased vascular endothelial cell number
def: "greater than normal number of cells lining the vasculature" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0006055 ! abnormal vascular endothelial cell morphology

[Term]
id: MP:0006057
name: decreased vascular endothelial cell number
def: "less than normal number of cells lining the vasculature" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "reduced vascular endothelial cell number" EXACT []
is_a: MP:0006055 ! abnormal vascular endothelial cell morphology

[Term]
id: MP:0006058
name: decreased cerebral infarct size
def: "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "reduced cerebral infarct size" EXACT []
is_a: MP:0006059 ! decreased susceptibility to ischemic brain injury

[Term]
id: MP:0006059
name: decreased susceptibility to ischemic brain injury
def: "less severe response, such as decreased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of all or part of the brain compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to ischaemic brain injury" EXACT []
synonym: "decreased susceptibility to spontaneous CNS ischaemia" RELATED []
synonym: "decreased susceptibility to spontaneous CNS ischemia" RELATED []
synonym: "increased resistance to ischaemic brain injury" EXACT []
synonym: "increased resistance to ischemic brain injury" EXACT []
synonym: "reduced susceptibility to ischaemic brain injury" EXACT []
synonym: "reduced susceptibility to ischemic brain injury" EXACT []
is_a: MP:0003075 ! abnormal response to CNS ischemic injury
is_a: MP:0005166 ! decreased susceptibility to injury
is_a: MP:0014522 ! decreased response to brain injury

[Term]
id: MP:0006060
name: increased cerebral infarct size
def: "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0003076 ! increased susceptibility to ischemic brain injury

[Term]
id: MP:0006061
name: right atrial isomerism
def: "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the right side of the body" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
is_a: MP:0000508 ! right-sided isomerism
is_a: MP:0006065 ! abnormal heart position or orientation
is_a: MP:0014319 ! abnormal heart atrium arrangement

[Term]
id: MP:0006062
name: abnormal vena cava morphology
def: "any structural anomaly of either of the two largest veins in the body" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal caval vein morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0006063
name: abnormal inferior vena cava morphology
def: "any structural anomaly of the principal vein draining blood from the lower portion of the body" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
subset: CvDC_Terms
synonym: "abnormal inferior caval vein morphology" EXACT []
synonym: "abnormal IVC morphology" EXACT []
synonym: "inferior vena cava anomaly" BROAD []
xref: Fyler:2810
is_a: MP:0006062 ! abnormal vena cava morphology

[Term]
id: MP:0006064
name: abnormal superior vena cava morphology
def: "any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
subset: CvDC_Terms
synonym: "abnormal precava morphology" EXACT []
synonym: "abnormal superior caval vein morphology" EXACT []
synonym: "abnormal SVC morphology" EXACT []
xref: Fyler:2820
is_a: MP:0006062 ! abnormal vena cava morphology

[Term]
id: MP:0006065
name: abnormal heart position or orientation
def: "the heart is displaced from the normal left-sided position and/or orientation" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0006066
name: decreased clearance of atrial thrombosis
def: "slower removal of a thrombus from the atria of the heart" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
synonym: "reduced clearance of atrial thrombosis" EXACT []
is_a: MP:0001855 ! abnormal atrial thrombosis

[Term]
id: MP:0006067
name: increased clearance of atrial thrombosis
def: "faster removal of a thrombus from the atria of the heart" [https://orcid.org/0000-0003-4606-0597, RGD:cur]
is_a: MP:0001855 ! abnormal atrial thrombosis

[Term]
id: MP:0006068
name: abnormal retina horizontal cell morphology
def: "any structural anomaly of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal horizontal cell morphology" EXACT []
synonym: "abnormal retinal horizontal cell morphology" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0006069
name: abnormal retina neuronal layer morphology
def: "any structural anomaly of any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [https://orcid.org/0000-0003-4606-0597, ISBN:0-914294-08-3]
synonym: "abnormal retinal neuronal layer morphology" EXACT []
is_a: MP:0003727 ! abnormal retina layer morphology

[Term]
id: MP:0006070
name: increased retina photoreceptor cell number
def: "greater than the expected number of rods and/or cones" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal photoreceptor cell number" EXACT []
is_a: MP:0001004 ! abnormal retina photoreceptor morphology
is_a: MP:0006006 ! increased sensory neuron number

[Term]
id: MP:0006071
name: abnormal retina progenitor cell morphology
def: "any structural anomaly of the cells that give rise to the various cells of the retina" [https://orcid.org/0000-0003-4606-0597, PMID:15363391]
synonym: "abnormal retinal progenitor cell morphology" EXACT []
is_a: MP:0009772 ! abnormal retina development

[Term]
id: MP:0006072
name: abnormal retina apoptosis
def: "change in the timing or the number of cells in the retina undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:15363391]
synonym: "abnormal retinal apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0006073
name: abnormal retina bipolar cell morphology
def: "any structural anomaly of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [https://orcid.org/0000-0003-4606-0597, PMID:15363390]
synonym: "abnormal retinal bipolar cell morphology" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0006074
name: abnormal retina rod bipolar cell morphology
def: "any structural anomaly of the bipolar cells that function in low light and transmit signals only through amacrine cells" [https://orcid.org/0000-0003-4606-0597, PMID:15363390]
synonym: "abnormal retinal rod bipolar cell morphology" EXACT []
is_a: MP:0006073 ! abnormal retina bipolar cell morphology

[Term]
id: MP:0006075
name: abnormal retina cone bipolar cell morphology
def: "any structural anomaly of the retinal bipolar cells that connect to both ganglion and amacrine cells" [https://orcid.org/0000-0003-4606-0597, PMID:15363390]
synonym: "abnormal retinal cone bipolar cell morphology" EXACT []
is_a: MP:0006073 ! abnormal retina bipolar cell morphology

[Term]
id: MP:0006076
name: abnormal circulating homocysteine level
def: "aberrant amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [https://orcid.org/0000-0003-3691-0324]
comment: A homocysteine measurement is the quantification of homocsyteine in blood or urine and is used in the diagnosis of B12 and/or folate deficiency, and as part of a cardiac risk assessment.
synonym: "abnormal blood serum homocysteine level" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level

[Term]
id: MP:0006077
name: inguinal hernia
def: "hernia through the abdominal wall in the region of the groin known as Hesselbach's triangle" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
is_a: MP:0000757 ! herniated abdominal wall

[Term]
id: MP:0006078
name: abnormal nipple morphology
def: "any structural anomaly of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8, ISBN:0803606559]
comment: Variation in number and arrangement of nipples is frequent on some mouse strains. For examples, fewer than five pairs are common in strain A females; more than five pairs in BALB/c females (Little, C.C., and H. MacDonald. 1945. Abnormalities of the mammae in the house mouse. J. Hered. 36: 285-288.)
synonym: "abnormal papilla mammae morphology" EXACT []
synonym: "abnormal papilla of breast morphology" EXACT []
synonym: "abnormal teat morphology" EXACT []
synonym: "abnormal thele morphology" EXACT []
synonym: "abnormal thelium morphology" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0006080
name: brain ischemia
def: "inadequate blood flow to a region of the brain that may lead to cerebral infarction" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "brain ischaemia" EXACT []
synonym: "cerebral ischaemia" EXACT []
synonym: "cerebral ischemia" EXACT []
synonym: "ischaemic stroke" RELATED []
synonym: "ischemic stroke" RELATED []
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0006082
name: CNS inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "encephalomyelitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0006083
name: abnormal blood vessel elastic tissue morphology
def: "any structural anomaly of the elastic tissue layer that lines a blood vessel layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal elastic laminae morphology" EXACT []
synonym: "abnormal vascular elastic tissue morphology" EXACT []
xref: MA:0002856
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0006084
name: abnormal circulating phospholipid level
def: "any anomaly in the concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0004777 ! abnormal phospholipid level

[Term]
id: MP:0006085
name: myocardium necrosis
def: "morphological changes resulting from pathological death of myocardial tissue; usually due to irreversible damage" [ISBN:0-683-40008-8]
synonym: "myocardial necrosis" EXACT []
synonym: "necrotic myocardium" EXACT []
is_a: MP:0005329 ! abnormal myocardium layer morphology
is_a: MP:0010632 ! cardiac muscle necrosis

[Term]
id: MP:0006086
name: decreased body mass index
def: "less than normal average of a measure of weight for height" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "decreased BMI" EXACT []
synonym: "reduced BMI" EXACT []
synonym: "reduced body mass index" EXACT []
is_a: MP:0020182 ! abnormal body mass index

[Term]
id: MP:0006087
name: increased body mass index
def: "greater than normal average of a measure of weight for height" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "increased BMI" EXACT []
is_a: MP:0020182 ! abnormal body mass index

[Term]
id: MP:0006088
name: abnormal blood-cerebrospinal fluid barrier function
def: "anomaly in the function of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood" [https://orcid.org/0000-0003-4606-0597, PMID:15314169]
synonym: "abnormal blood-CSF barrier" EXACT []
is_a: MP:0000249 ! abnormal blood vessel physiology
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0006089
name: abnormal vestibular saccule morphology
def: "any structural anomaly of the smaller of the two sacs in the vestibule" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559, PMID:15363417]
synonym: "abnormal saccule morphology" EXACT []
is_a: MP:0004425 ! abnormal otolith organ morphology

[Term]
id: MP:0006090
name: abnormal utricle morphology
def: "any structural anomaly of the larger of the two sacs in the vestibule" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559, PMID:15363417]
synonym: "abnormal utricular morphology" EXACT []
is_a: MP:0004425 ! abnormal otolith organ morphology

[Term]
id: MP:0006092
name: abnormal olfactory sensory neuron morphology
def: "any structural anomaly of the neurons in the olfactory epithelium that are activated by specific odorants" [https://orcid.org/0000-0003-4606-0597, MESH:A04.531.520.573.580]
synonym: "abnormal olfactory neuron morphology" EXACT []
synonym: "abnormal olfactory receptor neuron morphology" EXACT []
is_a: MP:0001001 ! abnormal chemoreceptor morphology
is_a: MP:0008789 ! abnormal olfactory epithelium morphology

[Term]
id: MP:0006093
name: arteriovenous malformation
def: "fusion of an artery and vein without an intervening capillary bed" [https://orcid.org/0000-0003-4606-0597]
synonym: "arteriovenous fistula" RELATED [https://www.compva.com/science/special-types-arteriovenous-malformation]
synonym: "AVM" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0006094
name: increased fat cell size
def: "increased size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, https://orcid.org/0000-0003-3691-0324]
synonym: "adipocyte hypertrophy" EXACT [MESH:A11.329.114]
synonym: "fat cell hypertrophy" EXACT []
synonym: "lipocyte hypertrophy" RELATED [MESH:A11.329.114]
is_a: MP:0009115 ! abnormal fat cell morphology

[Term]
id: MP:0006095
name: absent amacrine cells
def: "absence of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "absent amacrine neuron" EXACT []
is_a: MP:0008106 ! decreased amacrine cell number

[Term]
id: MP:0006096
name: absent retina bipolar cells
def: "absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11032813]
synonym: "absent retinal bipolar cells" EXACT []
is_a: MP:0006073 ! abnormal retina bipolar cell morphology

[Term]
id: MP:0006097
name: abnormal cerebellar lobule formation
def: "anomaly in the formation of the lobes of the cerebellum" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11032813]
is_a: MP:0000857 ! abnormal cerebellar foliation

[Term]
id: MP:0006098
name: absent cerebellar lobules
def: "missing lobes of the cerebellum" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009964 ! abnormal cerebellum lobule morphology

[Term]
id: MP:0006099
name: thin cerebellar granule layer
def: "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11032813]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased cerebellar granule layer width" EXACT []
synonym: "thin IGL" EXACT []
synonym: "thin internal granule layer" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0006100
name: abnormal tegmentum morphology
def: "any structural anomaly of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mesencephalic tegmentum morphology" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology

[Term]
id: MP:0006101
name: absent tegmentum
def: "absence or loss of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006100 ! abnormal tegmentum morphology

[Term]
id: MP:0006102
name: decreased tegmentum size
def: "reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "reduced tegmentum size" EXACT []
synonym: "thin tegmentum" EXACT []
is_a: MP:0006100 ! abnormal tegmentum morphology

[Term]
id: MP:0006103
name: abnormal midbrain roof plate morphology
def: "any structural anomaly of the mesencephalic roof plate, including the caudal and rostral part of the midbrain roof" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mesencephalon roof plate morphology" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology

[Term]
id: MP:0006104
name: abnormal tectum morphology
def: "any structural anomaly of the rostral part of the midbrain roof" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006103 ! abnormal midbrain roof plate morphology

[Term]
id: MP:0006105
name: small tectum
def: "reduced size of the rostral part of the midbrain roof" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, PMID:11032813]
synonym: "decreased tectum size" EXACT []
synonym: "reduced tectum size" EXACT []
synonym: "thin tectum" EXACT []
is_a: MP:0006104 ! abnormal tectum morphology

[Term]
id: MP:0006106
name: absent tectum
def: "absence or loss of the rostral part of the midbrain roof" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006104 ! abnormal tectum morphology

[Term]
id: MP:0006107
name: abnormal fetal atrioventricular canal morphology
def: "any structural anomaly of the common canal connecting the primordial atrium and ventricle during fetal development; the dorsal and ventral endocardial cushions develop in the walls of the common atrioventricular canal, grow toward each other and fuse, dividing the common atrioventricular canal into right and left atrioventricular canals and the atrioventricular septum" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal foetal atrioventricular canal morphology" EXACT []
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0006108
name: abnormal hindbrain development
def: "anomaly in the formation or pattering of the caudal region of the brain" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0006109
name: fibrillation
def: "asynchronous contraction or quivering of individual cardiac muscle fibers" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001636 ! irregular heartbeat

[Term]
id: MP:0006110
name: ventricular fibrillation
def: "asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0006109 ! fibrillation

[Term]
id: MP:0006111
name: abnormal coronary circulation
def: "any anomaly in the circulation of blood through the vessels that supply the heart" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0006112
name: angina
def: "inadequate blood flow to and/or oxygenation of the heart producing chest pain" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "angina pectoris" EXACT []
is_a: MP:0006111 ! abnormal coronary circulation

[Term]
id: MP:0006113
name: abnormal heart septum morphology
def: "any structural anomaly of the thin membranous structure between the two heart atria, the atria and the ventricles, or the thick muscular structure between the two heart ventricles" [MESH:A07.541.459, NCBI:matt]
synonym: "abnormal heart septa morphology" EXACT []
is_a: MP:0000266 ! abnormal heart morphology

[Term]
id: MP:0006114
name: cardiac murmur
def: "abnormal turbulent blood flow through the valves or outflow tract results in abnormal heart sounds" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0006115
name: aortic valve atresia
def: "congenital closure of the aortic valve" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "aortic semi-lunar valve atresia" EXACT []
synonym: "aortic semilunar valve atresia" EXACT []
synonym: "aortic valvar atresia" EXACT []
synonym: "left arterial valve atresia" EXACT []
synonym: "left semi-lunar valve atresia" EXACT []
synonym: "left semilunar valve atresia" EXACT []
synonym: "left ventriculoarterial junction atresia" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006116
name: calcified aortic valve
def: "pathologic deposition of calcium salts in the aortic valve" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "aortic valve calcification" EXACT []
synonym: "calcified aortic semi-lunar valve" EXACT []
synonym: "calcified aortic semilunar valve" EXACT []
synonym: "calcified left semi-lunar valve" EXACT []
synonym: "calcified left semilunar valve" EXACT []
synonym: "calcified left ventriculoarterial junction" EXACT []
synonym: "calicified left arterial valve" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology

[Term]
id: MP:0006117
name: aortic valve stenosis
def: "abnormal narrowing or constriction of the aortic valve" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, NCBI:matt]
comment: Do not confuse with aorta stenosis.
subset: CvDC_Terms
synonym: "aortic semi-lunar valve stenosis" EXACT []
synonym: "aortic semilunar valve stenosis" EXACT []
synonym: "aortic stenosis" RELATED []
synonym: "aortic valvar stenosis" EXACT []
synonym: "left arterial valve stenosis" EXACT []
synonym: "left semi-lunar valve stenosis" EXACT []
synonym: "left semilunar valve stenosis" EXACT []
synonym: "left ventriculoarterial junction stenosis" EXACT []
xref: Fyler:1411
is_a: MP:0002747 ! abnormal aortic valve morphology
is_a: MP:0010448 ! heart left ventricle outflow tract stenosis
is_a: MP:0031585 ! semilunar valve stenosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006118
name: aortic valve prolapse
def: "collapse of one or more of the aortic valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "aortic semi-lunar valve prolapse" EXACT []
synonym: "aortic semilunar valve prolapse" EXACT []
synonym: "aortic valvar prolapse" EXACT []
synonym: "left arterial valve prolapse" EXACT []
synonym: "left semi-lunar valve prolapse" EXACT []
synonym: "left semilunar valve prolapse" EXACT []
synonym: "left ventriculoarterial junction prolapse" EXACT []
xref: Fyler:1452
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006119
name: mitral valve atresia
def: "congenital closure of the mitral valve" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "bicuspid valve atresia" EXACT []
synonym: "left atrioventricular valve atresia" EXACT []
synonym: "left AV valve atresia" EXACT []
xref: Fyler:0310
xref: Fyler:310
is_a: MP:0000286 ! abnormal mitral valve morphology

[Term]
id: MP:0006120
name: mitral valve prolapse
def: "collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "bicuspid valve prolapse" EXACT []
synonym: "left atrioventricular valve prolapse" EXACT []
synonym: "left AV valve prolapse" EXACT []
synonym: "mitral valvar prolapse" EXACT []
xref: Fyler:1533
is_a: MP:0000286 ! abnormal mitral valve morphology

[Term]
id: MP:0006121
name: calcified mitral valve
def: "pathologic deposition of calcium salts in the mitral valve" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "bicuspid valve calcification" EXACT []
synonym: "calcified left atrioventricular valve" EXACT []
synonym: "calcified left AV valve" EXACT []
synonym: "left atrioventricular valve calcification" EXACT []
synonym: "left AV valve calcification" EXACT []
synonym: "mitral valve calcification" BROAD []
is_a: MP:0000286 ! abnormal mitral valve morphology

[Term]
id: MP:0006122
name: mitral valve stenosis
def: "abnormal narrowing or constriction of the mitral valve" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "bicuspid valve stenosis" NARROW []
synonym: "left atrioventricular valve stenosis" EXACT []
synonym: "left AV valve stenosis" EXACT []
xref: Fyler:1511
is_a: MP:0000286 ! abnormal mitral valve morphology
is_a: MP:0031575 ! atrioventricular valve stenosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006123
name: tricuspid valve atresia
def: "congenital closure of the tricuspid valve" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "right atrioventricular valve atresia" EXACT []
synonym: "right AV valve atresia" EXACT []
xref: Fyler:0400
xref: Fyler:400
is_a: MP:0002624 ! abnormal tricuspid valve morphology

[Term]
id: MP:0006124
name: tricuspid valve stenosis
def: "abnormal narrowing or constriction of the tricuspid valve" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "right atrioventricular valve stenosis" EXACT []
synonym: "right AV valve stenosis" EXACT []
synonym: "tricuspid stenosis" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
is_a: MP:0031575 ! atrioventricular valve stenosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006125
name: tricuspid valve prolapse
def: "collapse of one or more of the tricuspid valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: CvDC_Terms
synonym: "right atrioventricular valve prolapse" EXACT []
synonym: "right AV valve prolapse" EXACT []
xref: Fyler:1733
is_a: MP:0002624 ! abnormal tricuspid valve morphology

[Term]
id: MP:0006126
name: abnormal cardiac outflow tract development
def: "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery and the ventricular outflow regions" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "abnormal fetal outflow tract morphology" EXACT []
synonym: "abnormal foetal outflow tract morphology" EXACT []
synonym: "abnormal outflow tract development" EXACT []
is_a: MP:0002925 ! abnormal cardiovascular development

[Term]
id: MP:0006128
name: pulmonary valve stenosis
def: "abnormal narrowing or constriction of the pulmonary valve" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, NCBI:matt]
comment: Do not confuse with pulmonary artery stenosis, or infundibular pulmonary stenosis.
subset: CvDC_Terms
synonym: "pulmonary stenosis" RELATED []
synonym: "pulmonary stenosis, valvar" EXACT []
synonym: "pulmonary valvar stenosis" EXACT []
synonym: "pulmonic valve stenosis" EXACT []
synonym: "right arterial valve stenosis" EXACT []
synonym: "right semi-lunar valve stenosis" EXACT []
synonym: "right semilunar valve stenosis" EXACT []
xref: Fyler:1611
is_a: MP:0002748 ! abnormal pulmonary valve morphology
is_a: MP:0010449 ! heart right ventricle outflow tract stenosis
is_a: MP:0031585 ! semilunar valve stenosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006129
name: pulmonary valve prolapse
def: "collapse of one or more of the pulmonary valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "pulmonic valve prolapse" EXACT []
synonym: "right arterial valve prolapse" EXACT []
synonym: "right semi-lunar valve prolapse" EXACT []
synonym: "right semilunar valve prolapse" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006130
name: pulmonary valve atresia
def: "congenital closure of the pulmonary valve" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
comment: Do not confuse with pulmonary artery atresia.
subset: CvDC_Terms
synonym: "pulmonary atresia" BROAD []
synonym: "pulmonic valve atresia" EXACT []
synonym: "right arterial valve atresia" EXACT []
synonym: "right semi-lunar valve atresia" EXACT []
synonym: "right semilunar valve atresia" EXACT []
xref: Fyler:1001
is_a: MP:0002748 ! abnormal pulmonary valve morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0006131
name: calcified pulmonary valve
def: "pathologic deposition of calcium salts in the pulmonary valve" [https://orcid.org/0000-0003-4606-0597]
synonym: "calcified pulmonic valve" EXACT []
synonym: "calcified right arterial valve" EXACT []
synonym: "calcified right semi-lunar valve" EXACT []
synonym: "calcified right semilunar valve" EXACT []
synonym: "pulmonary valve calcification" EXACT []
synonym: "pulmonic valve calcification" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology

[Term]
id: MP:0006132
name: calcified tricuspid valve
def: "pathologic deposition of calcium salts in the tricuspid valve" [https://orcid.org/0000-0003-4606-0597]
synonym: "calcified right atrioventricular valve" EXACT []
synonym: "calcified right AV valve" EXACT []
synonym: "right atrioventricular valve calcification" EXACT []
synonym: "tricuspid valve calcification" BROAD []
is_a: MP:0002624 ! abnormal tricuspid valve morphology

[Term]
id: MP:0006133
name: calcified artery
def: "pathologic deposition of calcium salts in the arteries" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "arterial calcification" BROAD []
synonym: "artery calcification" BROAD []
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0006134
name: artery occlusion
def: "blockage of blood flow through one or more arteries" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "arterial occlusion" EXACT []
is_a: MP:0000255 ! blood vessel congestion
is_a: MP:0002191 ! abnormal artery morphology

[Term]
id: MP:0006135
name: artery stenosis
def: "abnormal constriction or narrowing of one or more arteries" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "arterial stenosis" RELATED []
is_a: MP:0002191 ! abnormal artery morphology
is_a: MP:0005412 ! vascular stenosis

[Term]
id: MP:0006136
name: varicose veins
def: "enlarged, twisted, painful superficial veins resulting from poorly functioning valves" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0006137
name: venoocclusion
def: "blockage of blood flow through one or more veins" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0000255 ! blood vessel congestion
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0006138
name: congestive heart failure
def: "cardiac output is insufficient to supply blood throughout the body, resulting in the accumulation of fluid in the lungs and other body tissues; it is related mainly to salt and water retention in the tissues rather than directly to reduced blood flow; blood pools in the veins (vascular congestion) because the heart does not pump efficiently enough to allow it to return" [NCBI:matt]
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0006140
name: increased cardiac rhabdomyoma incidence
def: "greater than the expected number of a benign tumor of the myocardium, occurring in a specific population in a given time period; it is most commonly seen in the young and is often associated with tuberous sclerosis" [ISBN:0-683-40008-8, NCBI:matt]
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0010291 ! increased cardiovascular system tumor incidence
is_a: MP:0010391 ! increased rhabdomyoma incidence

[Term]
id: MP:0006141
name: abnormal atrioventricular node conduction
def: "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "atrioventricular node defect" EXACT []
is_a: MP:0003137 ! abnormal impulse conducting system conduction

[Term]
id: MP:0006142
name: abnormal sinoatrial node conduction
def: "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
synonym: "sinoatrial node defect" BROAD []
synonym: "sinus node defect" BROAD []
xref: Fyler:7010
is_a: MP:0003137 ! abnormal impulse conducting system conduction

[Term]
id: MP:0006143
name: increased systemic arterial diastolic blood pressure
def: "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002842 ! increased systemic arterial blood pressure

[Term]
id: MP:0006144
name: increased systemic arterial systolic blood pressure
def: "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002842 ! increased systemic arterial blood pressure

[Term]
id: MP:0006145
name: legal blindness
def: "the best corrected visual acuity is 20/200, or the visual field is 20 degrees or less (sensu H. sapiens)" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002001 ! blindness

[Term]
id: MP:0006147
name: monocular blindness
def: "loss of vision in only one eye, may be transient" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002001 ! blindness

[Term]
id: MP:0006148
name: binocular blindness
def: "loss of vision in both eyes, may be transient" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002001 ! blindness

[Term]
id: MP:0006149
name: decreased visual acuity
def: "loss of visual acuity or ability to distinguish small details" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "blurred vision" RELATED []
is_a: MP:0011832 ! abnormal visual acuity

[Term]
id: MP:0006150
name: double vision
def: "two images are perceived when only a single object is present" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "diplopia" EXACT []
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0006151
name: cornea astigmatism
def: "the cornea is asymmetrically curved, causing out-of-focus vision" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "astigmatism" BROAD [https://orcid.org/0000-0002-6490-7723]
synonym: "corneal astigmatism" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0006152
name: tunnel vision
def: "loss of peripheral vision" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0006153
name: hypermetropia
def: "light entering the eye focuses behind the retina, instead of directly on it" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "farsighted" EXACT []
synonym: "hyperopia" EXACT []
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0006154
name: eye abduction
def: "abnormal movement of the eye laterally, or towards the temple" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0006155
name: eye adduction
def: "abnormal movement of the eye medially, or towards the nose" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0006156
name: abnormal visual pursuit
def: "anomaly in the ability to selectively track a moving object" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0006157
name: palsy of the eye
def: "the eye fails to move properly in all directions of gaze" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0006158
name: vertical supranuclear palsy
def: "inability to move the eye vertically" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0006157 ! palsy of the eye

[Term]
id: MP:0006159
name: ocular albinism
def: "absence of melanin (pigment) production in the eye with identifiable melanocytes present" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "absent eye pigment" BROAD []
is_a: MP:0008480 ! absent eye pigmentation

[Term]
id: MP:0006160
name: heterochromatic iridis
def: "a difference in color between the irises of the two eyes or between parts of one iris" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005102 ! abnormal iris pigmentation

[Term]
id: MP:0006162
name: thick eyelids
def: "increased width of the eyelid" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "thick eye lids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0006163
name: ankyloblepharon filiform
def: "abnormal connection of the upper and lower eyelids formed by fibrous tissue" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0006164
name: ectropion
def: "abnormal eversion of the upper or lower eyelid that leaves the eye exposed and dry" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "everted eye lids" EXACT []
synonym: "everted eyelids" EXACT []
synonym: "rolled out eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0006165
name: entropion
def: "abnormal inward rolling of the eyelid, most commonly the lower lid" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "inverted eye lids" EXACT []
synonym: "inverted eyelid" EXACT []
synonym: "rolled in eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0006166
name: eyelid retraction
def: "abnormal superior displacement of resting upper lid margin or abnormal inferior displacement of resting lower lid margin" [NCIT:C118866]
synonym: "blephara retraction" EXACT []
synonym: "blepharon retraction" EXACT []
synonym: "eye lid retraction" EXACT []
synonym: "palpebra retraction" EXACT []
synonym: "palpebrae retraction" EXACT []
is_a: MP:0003671 ! abnormal eyelid aperture

[Term]
id: MP:0006167
name: eyelid edema
def: "an abnormal accumulation of fluid in the eyelid" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "blepharedema" EXACT []
synonym: "blepharoedema" EXACT []
synonym: "eye lid edema" EXACT []
synonym: "eye lid oedema" EXACT []
synonym: "eyelid oedema" EXACT []
synonym: "palpebral edema" EXACT []
synonym: "palpebral oedema" EXACT []
synonym: "palpebredema" EXACT []
synonym: "palpebroedema" EXACT []
synonym: "puffy eyelids" EXACT []
synonym: "swollen eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology
is_a: MP:0001788 ! periorbital edema

[Term]
id: MP:0006168
name: epicanthus inversus
def: "a vertical fold of skin runs from the lower eyelid up either side of the nose" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0006169
name: increased eyelid tumor incidence
def: "greater than the expected number of abnormal rapidly proliferating cells in the eyelid, usually in the form of a distinct mass, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "eyelid tumor" RELATED []
synonym: "eyelid tumour" RELATED []
synonym: "increased eyelid tumour incidence" EXACT []
synonym: "tumor of the eyelid" RELATED []
synonym: "tumour of the eyelid" RELATED []
is_a: MP:0008018 ! increased facial tumor incidence

[Term]
id: MP:0006170
name: increased eyelid myxoma incidence
def: "higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of eyelid connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix" [MPATH:431]
synonym: "eyelid myxoma" RELATED []
is_a: MP:0003391 ! increased myxoma incidence
is_a: MP:0006169 ! increased eyelid tumor incidence

[Term]
id: MP:0006171
name: increased eyelid neuroma incidence
def: "greater than the expected number of a tumor composed of nerve tissue found in the eyelid, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "eyelid neuroma" RELATED []
is_a: MP:0006169 ! increased eyelid tumor incidence
is_a: MP:0010281 ! increased nervous system tumor incidence

[Term]
id: MP:0006172
name: increased eyelid lipodermoid incidence
def: "greater than the expected number of a congenital, yellowish-white, fatty, benign tumor located beneath the conjunctiva of the eye, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "eyelid lipodermoid" RELATED []
is_a: MP:0006169 ! increased eyelid tumor incidence

[Term]
id: MP:0006173
name: abnormal myeloid dendritic cell morphology
def: "any structural anomaly of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
synonym: "abnormal DC1 morphology" EXACT []
is_a: MP:0005461 ! abnormal dendritic cell morphology
is_a: MP:0008248 ! abnormal mononuclear phagocyte morphology

[Term]
id: MP:0006175
name: choroid atrophy
def: "acquired diminution of the size of the choroid associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
is_a: MP:0005098 ! abnormal optic choroid morphology

[Term]
id: MP:0006176
name: choroid degeneration
def: "a retrogressive impairment of function or destruction of the choroid" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "choroid dystrophy" EXACT []
is_a: MP:0005098 ! abnormal optic choroid morphology

[Term]
id: MP:0006177
name: choroid sclerosis
def: "thickening or hardening of the choroid usually secondary to atrophy" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005098 ! abnormal optic choroid morphology

[Term]
id: MP:0006180
name: increased choroid hemangioma incidence
def: "greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the choroid, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "choroid haemangioma" RELATED []
synonym: "choroid hemangioma" RELATED []
synonym: "increased choroid haemangioma incidence" EXACT []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0010304 ! increased choroid tumor incidence

[Term]
id: MP:0006182
name: increased retina hemangioma incidence
def: "greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the retina, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased retina haemangioma incidence" EXACT []
synonym: "increased retinal haemangioma incidence" EXACT []
synonym: "increased retinal hemangioma incidence" EXACT []
synonym: "retinal angioma" RELATED []
synonym: "retinal haemangioma" RELATED []
synonym: "retinal hemangioma" RELATED []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0010303 ! increased retina tumor incidence

[Term]
id: MP:0006183
name: increased retina hamartoma incidence
def: "greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the retina, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased retinal hamartoma incidence" EXACT []
synonym: "retina hamartoma" RELATED []
synonym: "retinal hamartoma" RELATED []
is_a: MP:0010303 ! increased retina tumor incidence
is_a: MP:0010306 ! increased hamartoma incidence

[Term]
id: MP:0006184
name: increased retina astrocytoma incidence
def: "greater than the expected number of a malignant tumor of nervous tissue composed of well-differentiated astrocytes located in the retina, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "increased retinal astrocytoma incidence" EXACT []
synonym: "retinal astrocytoma" RELATED []
is_a: MP:0010277 ! increased astrocytoma incidence
is_a: MP:0010303 ! increased retina tumor incidence

[Term]
id: MP:0006185
name: retina hemorrhage
def: "bleeding into the retina" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "retina haemorrhage" EXACT []
synonym: "retinal haemorrhage" EXACT []
synonym: "retinal hemorrhage" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
is_a: MP:0006203 ! eye hemorrhage

[Term]
id: MP:0006186
name: retina fibrosis
def: "invasion of fibrous connective tissue into the retina, often resulting from inflammation or injury" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "retinal fibrosis" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0006187
name: retina deposits
def: "abnormal accumulation of material on the retina" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "retinal deposits" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0006188
name: calcified retina
def: "pathologic deposition of calcium salts in the retina" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "retina calcification" BROAD []
synonym: "retinal calcification" BROAD []
is_a: MP:0006187 ! retina deposits
is_a: MP:0006209 ! calcified intraocular region

[Term]
id: MP:0006190
name: retina ischemia
def: "inadequate blood flow to the retina usually due to functional constriction or obstruction of a blood vessel" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "retina ischaemia" EXACT []
synonym: "retinal ischaemia" EXACT []
synonym: "retinal ischemia" EXACT []
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0006191
name: conjunctival deposits
def: "abnormal accumulation of material on the conjunctiva" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001310 ! abnormal conjunctiva morphology

[Term]
id: MP:0006192
name: abnormal conjunctival vasculature morphology
def: "any structural anomaly of the blood vessel network of the conjunctiva" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001310 ! abnormal conjunctiva morphology
is_a: MP:0031346 ! abnormal eye vasculature morphology

[Term]
id: MP:0006193
name: conjunctival telangiectasia
def: "vascular lesion formed by dilation of a group of small blood vessels in the conjunctiva" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "conjunctival telangiectases" EXACT []
synonym: "conjunctival telangiectasias" EXACT []
synonym: "conjunctival telangiectasis" EXACT []
is_a: MP:0004175 ! telangiectasia
is_a: MP:0006192 ! abnormal conjunctival vasculature morphology

[Term]
id: MP:0006194
name: keratoconjunctivitis
def: "inflammation of the conjunctiva and cornea" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0006197
name: ocular hypotelorism
def: "decreased interpupillary distance, i.e. decreased distance between the center of the pupils of the two eyes" [HP:0000601, https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597, NCBI:matt, PMID:19125427]
synonym: "abnormally close eyes" EXACT []
synonym: "close set eyes" RELATED []
synonym: "close-set eyes" RELATED []
synonym: "closely spaced eyes" EXACT []
synonym: "decreased distance between the eye sockets" EXACT []
synonym: "decreased distance between the eyes" EXACT []
synonym: "decreased interorbital distance" EXACT []
synonym: "decreased orbital separation" EXACT []
synonym: "reduced interpupillary distance" EXACT []
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0006198
name: enophthalmos
alt_id: MP:0006195
def: "recession of the eyeball within the orbit" [ISBN:0-683-40008-8]
synonym: "deep-set eyes" EXACT []
synonym: "enopthalmia" EXACT []
synonym: "sunken eyes" EXACT []
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0006199
name: hypertropia
def: "vertical misalignment between the eyes" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001299 ! abnormal eye distance/ position

[Term]
id: MP:0006200
name: vitreous body deposition
def: "abnormal accumulation of material in the vitreous body" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "corpus vitreum deposition" EXACT []
synonym: "hyaloid body deposition" EXACT []
synonym: "vitreal body deposition" EXACT []
synonym: "vitreum deposition" EXACT []
is_a: MP:0002699 ! abnormal vitreous body morphology

[Term]
id: MP:0006201
name: vitreous body inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "corpus vitreum inflammation" EXACT []
synonym: "hyaloid body inflammation" EXACT []
synonym: "vitreal body inflammation" EXACT []
synonym: "vitreum inflammation" EXACT []
is_a: MP:0003665 ! endophthalmitis

[Term]
id: MP:0006202
name: vitreous body hemorrhage
def: "bleeding into the vitreous body" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "corpus vitreum haemorrhage" EXACT []
synonym: "corpus vitreum hemorrhage" EXACT []
synonym: "hyaloid body haemorrhage" EXACT []
synonym: "hyaloid body hemorrhage" EXACT []
synonym: "vitreal body haemorrhage" EXACT []
synonym: "vitreal body hemorrhage" EXACT []
synonym: "vitreous body haemorrhage" EXACT []
synonym: "vitreum haemorrhage" EXACT []
synonym: "vitreum hemorrhage" EXACT []
is_a: MP:0002699 ! abnormal vitreous body morphology
is_a: MP:0006203 ! eye hemorrhage

[Term]
id: MP:0006203
name: eye hemorrhage
def: "bleeding into the eye" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
synonym: "eye haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0006204
name: embryonic lethality before implantation
def: "death anytime between fertilization and implantation (Mus: E0 to less than E4.5)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "embryonic death before implantation" EXACT []
synonym: "pre-implantation death" EXACT []
synonym: "pre-implantation lethality" EXACT []
synonym: "preimplantation death" EXACT []
synonym: "preimplantation lethality" EXACT []
is_a: MP:0013292 ! embryonic lethality prior to organogenesis

[Term]
id: MP:0006205
name: embryonic lethality between implantation and somite formation
def: "death anytime between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [https://orcid.org/0000-0003-4606-0597]
synonym: "embryonic death before somite formation" RELATED []
synonym: "embryonic lethality before somite formation" RELATED []
synonym: "postimplantation lethality" RELATED []
is_a: MP:0009850 ! embryonic lethality between implantation and placentation

[Term]
id: MP:0006206
name: embryonic lethality between somite formation and embryo turning
def: "death anytime between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [https://orcid.org/0000-0003-4606-0597]
synonym: "embryonic death before turning of embryo" RELATED []
synonym: "embryonic lethality before embryo turning" RELATED []
synonym: "embryonic lethality before turning of embryo" RELATED []
is_a: MP:0009850 ! embryonic lethality between implantation and placentation

[Term]
id: MP:0006207
name: embryonic lethality during organogenesis
def: "death anytime between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "embryonic death during organogenesis" EXACT []
is_a: MP:0008762 ! embryonic lethality

[Term]
id: MP:0006208
name: lethality throughout fetal growth and development
def: "death anytime between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
synonym: "embryonic death during fetal growth and development" RELATED []
synonym: "embryonic death during foetal growth and development" RELATED []
synonym: "embryonic lethality during fetal growth and development" RELATED []
synonym: "embryonic lethality during foetal growth and development" RELATED []
synonym: "embryonic lethality throughout fetal growth and development" RELATED []
synonym: "embryonic lethality throughout foetal growth and development" RELATED []
synonym: "lethality throughout foetal growth and development" EXACT []
is_a: MP:0002080 ! prenatal lethality
is_a: MP:0010832 ! lethality during fetal growth through weaning

[Term]
id: MP:0006209
name: calcified intraocular region
def: "pathologic deposition of calcium salts in the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "intraocular calcification" BROAD []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0006210
name: abnormal orbit size
def: "deviation from the normal size of the orbit" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0010030 ! abnormal orbit morphology

[Term]
id: MP:0006211
name: small orbits
def: "reduced size of the orbits" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "decreased orbit size" EXACT []
synonym: "reduced orbit size" EXACT []
is_a: MP:0006210 ! abnormal orbit size

[Term]
id: MP:0006212
name: large orbits
def: "increased size of the orbits" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "increased orbit size" EXACT []
is_a: MP:0006210 ! abnormal orbit size

[Term]
id: MP:0006213
name: shallow orbits
def: "decrease in the depth of the orbit" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0006210 ! abnormal orbit size

[Term]
id: MP:0006214
name: asymmetrical orbits
def: "loss of bilateral symmetry in the orbits" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0010030 ! abnormal orbit morphology

[Term]
id: MP:0006216
name: abnormal optic disk size
def: "deviation from the normal size of the optic disk" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "abnormal optic disc size" EXACT []
synonym: "abnormal optic nerve head size" RELATED []
is_a: MP:0008259 ! abnormal optic disk morphology

[Term]
id: MP:0006217
name: small optic disk
def: "reduced size of the optic disk" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "small optic disc" EXACT []
synonym: "small optic nerve head" RELATED []
is_a: MP:0006216 ! abnormal optic disk size

[Term]
id: MP:0006218
name: large optic disk
def: "increased size of the optic disk" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "large optic disc" EXACT []
synonym: "large optic nerve head" RELATED []
is_a: MP:0006216 ! abnormal optic disk size

[Term]
id: MP:0006219
name: optic nerve degeneration
def: "an active retrogressive pathologic deterioration of the optic nerve due to processes such as aberrant damage repair from injury, impaired blood flow or aging" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0006220
name: optic nerve compression
def: "a flattened or pressed appearance of the optic nerve as if by applied pressure" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0006221
name: optic nerve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the optic nerve, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "hypoplastic optic nerve" EXACT []
is_a: MP:0020342 ! small optic nerve

[Term]
id: MP:0006222
name: optic neuropathy
def: "damage of the optic nerve due to a blockage of its blood supply, to nutritional deficiencies, or to toxins" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0006223
name: optic nerve swelling
def: "accumulation of an excessive amount of fluid in the optic nerve; usually associated with an increase in intraocular pressure" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "papilledema" NARROW []
synonym: "pseudopapilledema" NARROW []
is_a: MP:0001330 ! abnormal optic nerve morphology
is_a: MP:0001785 ! edema

[Term]
id: MP:0006224
name: oculomotor apraxia
def: "impaired control of horizontal eye movements" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001389 ! abnormal eye movement

[Term]
id: MP:0006225
name: ocular rupture
def: "tearing of the tissues of the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0006226
name: iris hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the iris, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "hypoplastic iris" EXACT []
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0006228
name: iris atrophy
def: "acquired diminution of the size of the iris associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324, NCBI:matt]
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0006229
name: iris inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the iris" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005515 ! uveitis

[Term]
id: MP:0006230
name: iris stroma hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the iris stroma, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "hypoplastic iris stroma" EXACT []
is_a: MP:0005208 ! abnormal iris stroma morphology
is_a: MP:0006226 ! iris hypoplasia

[Term]
id: MP:0006232
name: increased Lisch nodule incidence
def: "greater than the expected number of benign focal malformations in the iris in a specific population in a given time period; results from faulty iris development, and is composed of an abnormal mixture of tissue elements including melanocytes, or an abnormal proportion of a single element normally present at that site" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased iris hamartoma incidence" EXACT []
synonym: "iris hamartoma" RELATED []
synonym: "Lisch nodule" RELATED []
is_a: MP:0010305 ! increased iris tumor incidence
is_a: MP:0010306 ! increased hamartoma incidence

[Term]
id: MP:0006234
name: iridoschisis
def: "separation of the anterior iris stroma from the posterior stroma and muscle layers" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0006235
name: polycoria
def: "two or more pupils in one iris each with sphincter muscle" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0006236
name: absent Meibomian glands
def: "missing meibomian glands" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005252 ! abnormal Meibomian gland morphology

[Term]
id: MP:0006237
name: abnormal choroid vasculature morphology
def: "any structural anomaly of the blood vessels of the choroid" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005098 ! abnormal optic choroid morphology
is_a: MP:0031346 ! abnormal eye vasculature morphology

[Term]
id: MP:0006238
name: abnormal choriocapillaris morphology
def: "any structural anomaly of the capillaries forming the inner vascular layer of the choroid of the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0003658 ! abnormal capillary morphology
is_a: MP:0006237 ! abnormal choroid vasculature morphology

[Term]
id: MP:0006239
name: absent choriocapillaris
def: "missing capillaries forming the inner vascular layer of the choroid of the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0006238 ! abnormal choriocapillaris morphology

[Term]
id: MP:0006240
name: anisocoria
def: "unequal size of pupils" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0006241
name: abnormal placement of pupils
def: "abnormal location of the pupil so that it is not in the center of the iris" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "corectopia" EXACT []
synonym: "ectopic pupil" EXACT []
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0006242
name: white pupil
def: "reflective white mass within the eye that gives the appearance of white pupil" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "leucokoria" EXACT []
synonym: "leukokoria" EXACT []
is_a: MP:0001317 ! abnormal pupil morphology

[Term]
id: MP:0006243
name: impaired pupillary reflex
def: "the pupil fails to constrict fully when exposed to bright light" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal pupil dilation reaction to light" EXACT []
synonym: "Marcus-Gunn pupil" EXACT []
is_a: MP:0002638 ! abnormal pupillary reflex

[Term]
id: MP:0006244
name: eyelid muscle spasm
def: "repetitive, involuntary spasm of the eyelid muscles; a twitch usually occurs in the upper eyelid, but it can occur in both the upper and lower eyelids" [https://orcid.org/0000-0002-6490-7723]
synonym: "blepharospasm" EXACT []
synonym: "eyelid spasm" EXACT []
synonym: "eyelid twitch" EXACT []
synonym: "eyelid twitching" EXACT []
synonym: "involuntary closure of eyelid" EXACT []
synonym: "involuntary contraction of eyelids" EXACT []
synonym: "spontaneous closure of eyelid" EXACT []
synonym: "twitching eyelid" EXACT []
is_a: MP:0005253 ! abnormal eye physiology
is_a: MP:0030143 ! facial muscle spasm

[Term]
id: MP:0006245
name: obsolete dislocated lens
def: "OBSOLETE. the lens is moved out of position because some or all of the supporting ligaments have broken" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_obsolete: true
replaced_by: MP:0031428

[Term]
id: MP:0006248
name: lagophthalmos
def: "inability to completely close the eye" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0006249
name: phthisis bulbi
def: "small, shrunken, malformed eye that usually represents an acquired shrinkage of the eye following trauma, infection, or the end result of eye disease rather than a primary developmental defect" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "shrunken eye" RELATED []
is_a: MP:0002697 ! abnormal eye size

[Term]
id: MP:0006250
name: abnormal line of Schwalbe morphology
def: "any structural anomaly of the thickened peripheral margin of the vitreous membrane of the cornea" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
synonym: "abnormal Schwalbe's ring morphology" EXACT []
is_a: MP:0005203 ! abnormal trabecular meshwork morphology

[Term]
id: MP:0006251
name: eyelid apraxia
def: "impaired ability to open the eyelids without any gross defect in eyelid morphology" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0006252
name: lateral rectus palsy
def: "paralysis of the lateral rectus muscle preventing medially deviated and movement laterally from the midline" [https://orcid.org/0000-0003-4606-0597, NCBI:matt]
is_a: MP:0006157 ! palsy of the eye

[Term]
id: MP:0006253
name: clinodactyly
def: "abnormal lateral curvature of one or more digits towards or away from each other" [https://orcid.org/0000-0003-4606-0597]
synonym: "bent digits" EXACT []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0006254
name: thin cerebral cortex
def: "decreased depth of the mantle covering the surface of the cerebral hemispheres" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0006256
name: abnormal gustatory papillae morphology
def: "any structural anomaly of the papillae that contain taste buds, including the fungiform, foliate, and circumvallate papillae" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal taste papillae morphology" EXACT []
is_a: MP:0000764 ! abnormal tongue epithelium morphology

[Term]
id: MP:0006257
name: abnormal fungiform papillae morphology
def: "any structural anomaly of the mushroom-shaped papillae, which have a single taste bud at the tip, located mostly on the dorsal anterior portion of the tongue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006256 ! abnormal gustatory papillae morphology

[Term]
id: MP:0006258
name: abnormal circumvallate papillae morphology
def: "any structural anomaly of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal vallate papillae" EXACT []
is_a: MP:0006256 ! abnormal gustatory papillae morphology

[Term]
id: MP:0006259
name: abnormal foliate papillae morphology
def: "any structural anomaly of the papillae located on the sides of the tongue" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
is_a: MP:0006256 ! abnormal gustatory papillae morphology

[Term]
id: MP:0006260
name: abnormal gustatory papilla taste bud morphology
def: "any structural anomaly of the lingual taste buds found exclusively within gustatory papillae of the tongue, including the circumvallate, foliate, and fungiform papillae" [PMID:31604544, UBERON:0014451]
synonym: "abnormal gustatory papillae taste bud morphology" EXACT []
synonym: "abnormal gustatory papillae taste buds" RELATED []
synonym: "abnormal tongue taste bud morphology" EXACT []
is_a: MP:0006256 ! abnormal gustatory papillae morphology
is_a: MP:0031468 ! abnormal taste bud morphology

[Term]
id: MP:0006261
name: annular pancreas
def: "an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0006262
name: increased testis tumor incidence
def: "greater than the expected number of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased testicular tumor incidence" EXACT []
synonym: "increased testicular tumour incidence" EXACT []
synonym: "increased testis tumour incidence" EXACT []
synonym: "testis tumor" RELATED []
synonym: "testis tumour" RELATED []
is_a: MP:0001146 ! abnormal testis morphology
is_a: MP:0009590 ! increased gonad tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0006263
name: decreased systemic arterial diastolic blood pressure
def: "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [https://orcid.org/0009-0005-7755-8314]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced diastolic blood pressure" EXACT []
is_a: MP:0002843 ! decreased systemic arterial blood pressure

[Term]
id: MP:0006264
name: decreased systemic arterial systolic blood pressure
def: "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [https://orcid.org/0009-0005-7755-8314]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "reduced systolic blood pressure" EXACT []
is_a: MP:0002843 ! decreased systemic arterial blood pressure

[Term]
id: MP:0006265
name: increased pulse pressure
def: "increase in the difference between systolic and diastolic blood pressure" [RGD:cur]
is_a: MP:0003882 ! abnormal pulse pressure

[Term]
id: MP:0006266
name: decreased pulse pressure
def: "decrease in the difference between systolic and diastolic blood pressure" [RGD:cur]
synonym: "reduced pulse pressure" EXACT []
is_a: MP:0003882 ! abnormal pulse pressure

[Term]
id: MP:0006267
name: abnormal intercalated disk morphology
def: "any structural anomaly in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes; the intercalated discs permit communication between the cells such that there is a sequential contraction of the cells from the bottom of the ventricle to the top, facilitating maximal ejection of blood from the ventricle during contraction" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intercalated disc morphology" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0006268
name: absent cardiac desmosomes
def: "absence of one type of membrane junctions found within the intercalated discs that provide mechanical integrity and prevent separation of adjacent cells during contraction of cardiac tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cardiac macula adherens" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0006269
name: abnormal mammary gland growth during pregnancy
def: "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
is_a: MP:0000628 ! abnormal mammary gland development
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0006270
name: abnormal mammary gland growth during lactation
def: "anomaly in the final stage of mammary growth that occurs during the start of lactation" [MGI:llw2]
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0006271
name: abnormal involution of the mammary gland
def: "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [MGI:llw2]
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0006272
name: abnormal urine organic anion level
def: "any change in the amount of organic anions in the urine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal kidney organic anion excretion" EXACT []
synonym: "abnormal renal organic anion excretion" EXACT []
synonym: "abnormal renal organic anion secretion" EXACT []
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0006273
name: abnormal urine organic cation level
def: "any change in the amount of organic cations in the urine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal kidney organic cation excretion" EXACT []
synonym: "abnormal renal organic cation excretion" RELATED []
synonym: "abnormal renal organic cation secretion" EXACT []
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0006274
name: abnormal urine sodium level
alt_id: MP:0006312
def: "any change in the amount of sodium in the urine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal kidney sodium excretion" EXACT []
synonym: "abnormal renal sodium excretion" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0020889 ! abnormal sodium level

[Term]
id: MP:0006276
name: abnormal autonomic nervous system physiology
def: "any functional anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions" [https://orcid.org/0000-0002-6490-7723, ISBN:0803606559]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0006277
name: abnormal parasympathetic nervous system physiology
def: "any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0006276 ! abnormal autonomic nervous system physiology

[Term]
id: MP:0006278
name: aortic aneurysm
def: "a protruding sac formed by the dilation of the wall of the aorta resulting from a weakening of the vessel wall" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:2301
is_a: MP:0003279 ! aneurysm
is_a: MP:0010574 ! dilated aorta

[Term]
id: MP:0006279
name: abnormal limb development
def: "anomaly in the formation of the limbs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0006280
name: abnormal digit development
def: "anomaly in the formation of the digits" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006279 ! abnormal limb development

[Term]
id: MP:0006281
name: abnormal tail development
def: "anomaly in the formation of the tail" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0006282
name: abnormal spinal cord dorsal horn morphology
def: "any structural anomaly of the pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord" [ISBN:0-683-40008-8]
comment: Note that the synonym posterior column may refer to either the grey matter dorsal horn or the white matter dorsal column in the spinal cord. Posterior horn may also refer to a region of the brain lateral ventricles.
synonym: "abnormal dorsal horn morphology" EXACT []
synonym: "abnormal posterior column morphology" EXACT []
synonym: "abnormal posterior cornu morphology" EXACT []
synonym: "abnormal posterior gray horn morphology" EXACT []
synonym: "abnormal posterior horn morphology" EXACT []
xref: MA:0001119
is_a: MP:0008503 ! abnormal spinal cord grey matter morphology

[Term]
id: MP:0006283
name: increased medulloblastoma incidence
def: "greater than the expected number of a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-4606-0597, MGI:rbabiuk]
synonym: "medulloblastoma" RELATED []
synonym: "primitive neuroendocrine tumor" RELATED []
synonym: "primitive neuroendocrine tumour" RELATED []
is_a: MP:0008021 ! increased blastoma incidence
is_a: MP:0009277 ! increased brain tumor incidence

[Term]
id: MP:0006284
name: absent hypaxial muscle
def: "absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [https://orcid.org/0000-0002-6490-7723, PMID:1591996]
is_a: MP:0003358 ! abnormal hypaxial muscle morphology

[Term]
id: MP:0006285
name: absent inner ear
def: "absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0006286
name: inner ear hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the inner ear, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic inner ear" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology

[Term]
id: MP:0006287
name: inner ear cyst
def: "presence of one or more abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic inner ear" EXACT []
synonym: "inner ear cysts" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0006288
name: small otic capsule
def: "reduced size of the cartilage or bony capsule surrounding the inner ear mechanism" [https://orcid.org/0000-0002-6490-7723]
synonym: "small auditory capsule" EXACT []
is_a: MP:0000039 ! abnormal otic capsule morphology

[Term]
id: MP:0006289
name: otic capsule hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the otic capsule, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic auditory capsule" EXACT []
synonym: "hypoplastic otic capsule" EXACT []
is_a: MP:0006288 ! small otic capsule

[Term]
id: MP:0006290
name: proboscis
def: "a long, cylindrical protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011495 ! abnormal head shape

[Term]
id: MP:0006291
name: aprosencephaly
def: "derivatives of the telencephalon and diencephalon are absent or dysplastic but more caudal brain structures are largely normal or only mildly deformed" [https://radiopaedia.org/articles/aprosencephaly?lang=us]
is_a: MP:0003232 ! abnormal forebrain development

[Term]
id: MP:0006292
name: abnormal nasal placode morphology
def: "any structural anomaly in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal olfactory placodes" BROAD []
synonym: "olfactory placode dysplasia" NARROW []
is_a: MP:0003115 ! abnormal respiratory system development
is_a: MP:0003935 ! abnormal craniofacial development
is_a: MP:0005499 ! abnormal olfactory system morphology

[Term]
id: MP:0006293
name: absent nasal placodes
def: "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "absent olfactory placodes" EXACT []
is_a: MP:0006292 ! abnormal nasal placode morphology

[Term]
id: MP:0006294
name: absent optic vesicle
def: "absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ocular vesicle" EXACT []
synonym: "absent ophthalmic vesicle" EXACT []
synonym: "absent vesicula ophthalmica" EXACT []
is_a: MP:0003425 ! abnormal optic vesicle formation

[Term]
id: MP:0006295
name: absent sclerotome
def: "absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006029 ! abnormal sclerotome morphology

[Term]
id: MP:0006296
name: arachnodactyly
def: "the digits are abnormally long and slender" [ISBN:0803606559, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "achromachia" EXACT []
synonym: "spider fingers" NARROW []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0006297
name: obsolete loss of abdominal adipose tissue
def: "OBSOLETE. reduction in amount or absence of adipose tissue associated with internal organs" [MGI:llw2]
comment: This term has been rendered obsolete.  Use decreased abdominal adipose tissue amount MP:0008853 instead.
is_obsolete: true
consider: MP:0008844

[Term]
id: MP:0006298
name: abnormal platelet activation
def: "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal thrombocyte activation" RELATED []
is_a: MP:0005464 ! abnormal platelet physiology

[Term]
id: MP:0006299
name: abnormal latent inhibition of conditioning behavior
def: "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [http://dionysus.psych.wisc.edu/ARL/research-current.html, https://orcid.org/0000-0003-4606-0597, MGI:brs]
synonym: "abnormal latent inhibition of conditioning behaviour" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0006300
name: abnormal entorhinal cortex morphology
def: "any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus" [MGI:brs]
synonym: "abnormal Brodmann's area 28 morphology" EXACT []
synonym: "abnormal entorhinal area morphology" EXACT []
is_a: MP:0004168 ! abnormal parahippocampal gyrus morphology

[Term]
id: MP:0006301
name: abnormal mesenchyme morphology
def: "any structural anomaly of the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems" [https://orcid.org/0000-0003-0431-8641]
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0006302
name: abnormal ectomesenchyme morphology
def: "any structural anomaly in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches" [https://orcid.org/0000-0003-0431-8641, PMID:17067568]
is_a: MP:0011260 ! abnormal head mesenchyme morphology

[Term]
id: MP:0006303
name: abnormal retina nerve fiber layer morphology
def: "any structural anomaly of the layer of the retina formed by expansion of the fibers of the optic nerve" [https://orcid.org/0000-0003-4606-0597, ISBN:0-914294-08-3]
synonym: "abnormal retina nerve fibre layer morphology" EXACT []
synonym: "abnormal retinal nerve fiber layer morphology" EXACT []
synonym: "abnormal retinal nerve fibre layer morphology" EXACT []
synonym: "abnormal stratum opticum morphology" EXACT []
is_a: MP:0006069 ! abnormal retina neuronal layer morphology

[Term]
id: MP:0006305
name: abnormal optic eminence morphology
def: "any structural anomaly of the embryonic structure that gives rise to the corneal ectoderm" [http://embryology.med.unsw.edu.au/Notes/eye.htm#stage13, https://orcid.org/0000-0003-4606-0597, PMID:17334657]
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0006306
name: abnormal nasal pit morphology
def: "any structural anomaly of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus; the nasal pits indent the fronto-nasal process and divide it into a medial and two lateral nasal processes" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597, ISBN:0-683-40008-8]
synonym: "abnormal olfactory pit morphology" EXACT []
is_a: MP:0003115 ! abnormal respiratory system development
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0006307
name: abnormal seminiferous tubule size
def: "alteration in the diameter of the tubules in the testes where spermatogenesis occurs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002216 ! abnormal seminiferous tubule morphology

[Term]
id: MP:0006308
name: enlarged seminiferous tubules
def: "increased diameter of the tubules in the testes where spermatogenesis occurs" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased seminiferous tubule size" EXACT []
is_a: MP:0006307 ! abnormal seminiferous tubule size

[Term]
id: MP:0006309
name: decreased retina ganglion cell number
def: "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal ganglion cell number" EXACT []
synonym: "reduced retina ganglion cell number" EXACT []
synonym: "reduced retinal ganglion cell number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0008056 ! abnormal retina ganglion cell morphology

[Term]
id: MP:0006310
name: increased retinoblastoma incidence
def: "higher than normal incidence of a malignant tumor of the retina composed of cells arising from the retinoblasts" [ISBN:0803606559, MGI:rbabiuk]
synonym: "retinoblastoma" RELATED []
is_a: MP:0008021 ! increased blastoma incidence
is_a: MP:0010303 ! increased retina tumor incidence

[Term]
id: MP:0006315
name: abnormal urine protein level
def: "anomaly in the amount of protein in the urine" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal kidney protein excretion" EXACT []
synonym: "abnormal renal protein excretion" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0006316
name: increased urine sodium level
alt_id: MP:0005569
alt_id: MP:0006275
def: "higher than normal amount of sodium in the urine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "increased sodium excretion" EXACT []
synonym: "natriuresis" EXACT []
is_a: MP:0006274 ! abnormal urine sodium level

[Term]
id: MP:0006317
name: decreased urine sodium level
alt_id: MP:0005570
def: "lower than normal amount of sodium in the urine" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sodium excretion" EXACT []
synonym: "reduced sodium excretion" EXACT []
synonym: "reduced urine sodium level" EXACT []
is_a: MP:0006274 ! abnormal urine sodium level

[Term]
id: MP:0006319
name: abnormal epididymal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [https://orcid.org/0000-0003-4606-0597, MGI:rbabiuk]
synonym: "abnormal epididymal fat depot morphology" EXACT []
synonym: "abnormal periepididymal fat pad morphology" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0006320
name: abnormal interscapular fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [https://orcid.org/0000-0003-4606-0597, MGI:rbabiuk]
synonym: "abnormal interscapular fat depot morphology" EXACT []
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0006321
name: increased myocardial fiber number
def: "increased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart" [https://orcid.org/0000-0003-4606-0597, https://orcid.org/0009-0005-7755-8314]
synonym: "increased adult cardiomyocyte number" EXACT []
synonym: "increased myocardial fibre number" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology

[Term]
id: MP:0006322
name: abnormal perichondrium morphology
def: "any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "perichondrium dysplasia" NARROW []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0006323
name: abnormal extraembryonic mesoderm development
def: "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion, yolk sac, and body stalk" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal primary mesoderm formation" EXACT []
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology

[Term]
id: MP:0006324
name: abnormal cochlear nerve fiber response
def: "anomaly in the electrophysiological recordings from a single or several auditory nerve fiber(s)" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal auditory nerve fiber response" EXACT []
synonym: "abnormal auditory nerve fibre response" EXACT []
synonym: "abnormal cochlear nerve fibre response" EXACT []
is_a: MP:0003477 ! abnormal nerve fiber response
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0006325
name: impaired hearing
def: "reduced ability to perceive auditory stimuli" [https://orcid.org/0000-0003-4606-0597]
synonym: "hearing loss" RELATED []
is_a: MP:0001963 ! abnormal hearing physiology

[Term]
id: MP:0006326
name: conductive hearing impairment
def: "reduction in the ability to hear due to lesions in the external auditory canal or middle ear" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0006327
name: mixed hearing impairment
def: "reduced ability to hear resulting from a combination of conductive and sensorineural hearing impairment" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0006328
name: nonsyndromic hearing impairment
def: "a form of hearing impairment that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0006329
name: sensorineural hearing impairment
def: "a form of hearing impairment due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [https://orcid.org/0000-0003-4606-0597]
synonym: "perceptive hearing impairment" RELATED []
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0006330
name: syndromic hearing impairment
def: "hearing impairment that is usually associated with malformations of the external ear and other inherited signs and symptoms" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006325 ! impaired hearing

[Term]
id: MP:0006331
name: abnormal patterning of the organ of Corti
def: "anomaly in the organization of the various cell types within the organ of Corti into a set number of distinct rows" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000042 ! abnormal organ of Corti morphology

[Term]
id: MP:0006332
name: abnormal cochlear potential
def: "anomaly in the evoked response of the cochlea" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0006334
name: abnormal susceptibility to hearing loss
def: "anomaly in the sensitivity to loss of hearing related to age or environmental factors" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal resistance to hearing loss" EXACT []
is_a: MP:0001963 ! abnormal hearing physiology

[Term]
id: MP:0006335
name: abnormal hearing electrophysiology
def: "anomaly in auditory function as it relates to electrical phenomena" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001963 ! abnormal hearing physiology

[Term]
id: MP:0006336
name: abnormal otoacoustic response
def: "anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal otoacoustic emissions" EXACT []
is_a: MP:0001963 ! abnormal hearing physiology

[Term]
id: MP:0006337
name: abnormal first pharyngeal arch morphology
def: "any structural anomaly of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal first branchial arch morphology" EXACT []
synonym: "abnormal mandibular arch morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006338
name: abnormal second pharyngeal arch morphology
def: "any structural anomaly of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal hyoid arch morphology" EXACT []
synonym: "abnormal second branchial arch morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006339
name: abnormal third pharyngeal arch morphology
def: "any structural anomaly of the third arch which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal third branchial arch morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006340
name: abnormal fourth pharyngeal arch morphology
def: "any structural anomaly of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [https://orcid.org/0000-0003-4606-0597, zillmusom:http\://musom.marshall.edu/anatomy/grosshom/z_devbranc.html]
synonym: "abnormal fourth branchial arch morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006341
name: small first pharyngeal arch
def: "reduced size of the first branchial arch" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased first pharyngeal arch size" EXACT []
synonym: "small first branchial arch" EXACT []
is_a: MP:0006337 ! abnormal first pharyngeal arch morphology
is_a: MP:0006346 ! small pharyngeal arch

[Term]
id: MP:0006342
name: absent first pharyngeal arch
def: "absence of the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent first branchial arch" EXACT []
is_a: MP:0003874 ! absent pharyngeal arches
is_a: MP:0006337 ! abnormal first pharyngeal arch morphology

[Term]
id: MP:0006343
name: enlarged first pharyngeal arch
def: "increased size of the first branchial arch" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged first branchial arch" EXACT []
synonym: "increased first pharyngeal arch size" EXACT []
is_a: MP:0006337 ! abnormal first pharyngeal arch morphology
is_a: MP:0030312 ! enlarged pharyngeal arch

[Term]
id: MP:0006344
name: small second pharyngeal arch
def: "reduced size of the second branchial arch" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased second pharyngeal arch size" EXACT []
synonym: "small second branchial arch" EXACT []
is_a: MP:0006338 ! abnormal second pharyngeal arch morphology
is_a: MP:0006346 ! small pharyngeal arch

[Term]
id: MP:0006345
name: absent second pharyngeal arch
def: "absence of the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent second branchial arch" EXACT []
is_a: MP:0003874 ! absent pharyngeal arches
is_a: MP:0006338 ! abnormal second pharyngeal arch morphology

[Term]
id: MP:0006346
name: small pharyngeal arch
def: "reduced size of one or more of the branchial arches" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased pharyngeal arch size" EXACT []
synonym: "reduced pharyngeal arch size" EXACT []
synonym: "small branchial arch" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006347
name: abnormal sixth pharyngeal arch morphology
def: "any structural anomaly of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles" [https://orcid.org/0000-0003-4606-0597, zillmusom:http\://musom.marshall.edu/anatomy/grosshom/z_devbranc.html]
synonym: "abnormal sixth branchial arch morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0006348
name: abnormal circulating copper level
def: "any anomaly in the blood concentration of copper" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
is_a: MP:0003952 ! abnormal copper level
is_a: MP:0006357 ! abnormal circulating mineral level

[Term]
id: MP:0006349
name: decreased circulating copper level
def: "less than the normal concentration of copper in the blood" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
synonym: "hypocupraemia" EXACT []
synonym: "hypocupremia" EXACT []
synonym: "reduced circulating copper level" EXACT []
is_a: MP:0006348 ! abnormal circulating copper level
is_a: MP:0014548 ! decreased circulating mineral level

[Term]
id: MP:0006350
name: increased circulating copper level
def: "greater than normal concentration of copper in the blood" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
synonym: "hypercupraemia" EXACT []
synonym: "hypercupremia" EXACT []
is_a: MP:0006348 ! abnormal circulating copper level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0006351
name: abnormal glycosylated hemoglobin level
def: "aberrant concentration in the blood of modified form of hemoglobin with an attached saccharide molecule; this is commonly used to estimate blood glucose levels over the lifespan of the red blood cell" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
synonym: "abnormal glycosylated haemoglobin A1c level" EXACT []
synonym: "abnormal glycosylated haemoglobin level" EXACT []
synonym: "abnormal glycosylated hemoglobin A1c level" EXACT []
synonym: "abnormal HbA1c levels" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0005563 ! abnormal hemoglobin content

[Term]
id: MP:0006352
name: decreased glycosylated hemoglobin level
def: "lower than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
synonym: "decreased glycosylated haemoglobin A1c level" EXACT []
synonym: "decreased glycosylated haemoglobin level" EXACT []
synonym: "decreased glycosylated hemoglobin A1c level" EXACT []
synonym: "decreased HbA1c level" EXACT []
synonym: "reduced glycosylated haemoglobin level" EXACT []
synonym: "reduced glycosylated hemoglobin level" EXACT []
is_a: MP:0006351 ! abnormal glycosylated hemoglobin level
is_a: MP:0014502 ! decreased circulating protein level

[Term]
id: MP:0006353
name: increased glycosylated hemoglobin level
def: "greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule" [https://orcid.org/0000-0003-4606-0597, MGI:Riken]
synonym: "increased glycosylated haemoglobin A1c level" EXACT []
synonym: "increased glycosylated haemoglobin level" EXACT []
synonym: "increased glycosylated hemoglobin A1c level" EXACT []
synonym: "increased HbA1c level" EXACT []
is_a: MP:0006351 ! abnormal glycosylated hemoglobin level
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0006354
name: abnormal fourth pharyngeal arch artery morphology
def: "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fourth aortic arch" EXACT []
synonym: "abnormal fourth branchial arch artery morphology" EXACT []
synonym: "abnormal fourth PAA" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006340 ! abnormal fourth pharyngeal arch morphology

[Term]
id: MP:0006355
name: abnormal sixth pharyngeal arch artery morphology
def: "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sixth aortic arch" EXACT []
synonym: "abnormal sixth branchial arch artery morphology" EXACT []
synonym: "abnormal sixth PAA" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006347 ! abnormal sixth pharyngeal arch morphology

[Term]
id: MP:0006356
name: abnormal third pharyngeal arch artery morphology
def: "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal carotid arch morphology" EXACT []
synonym: "abnormal third aortic arch" EXACT []
synonym: "abnormal third branchial arch artery morphology" EXACT []
synonym: "abnormal third PAA" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006339 ! abnormal third pharyngeal arch morphology

[Term]
id: MP:0006357
name: abnormal circulating mineral level
def: "any anomaly in the concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0006358
name: absent pinna reflex
def: "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "absent ear twitch response" EXACT []
synonym: "absent Preyer's reflex" EXACT []
is_a: MP:0001485 ! abnormal pinna reflex

[Term]
id: MP:0006359
name: absent startle reflex
def: "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001486 ! abnormal startle reflex

[Term]
id: MP:0006361
name: abnormal female germ cell morphology
def: "any structural anomaly female germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2]
is_a: MP:0002208 ! abnormal germ cell morphology

[Term]
id: MP:0006362
name: abnormal male germ cell morphology
def: "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2]
is_a: MP:0002208 ! abnormal germ cell morphology

[Term]
id: MP:0006363
name: absent auchene hairs
def: "absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0000405 ! abnormal auchene hair morphology

[Term]
id: MP:0006364
name: absent awl hair
def: "absence of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0000400 ! abnormal awl hair morphology

[Term]
id: MP:0006365
name: absent guard hair
def: "absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "absent monotrich hair" EXACT []
is_a: MP:0000397 ! abnormal guard hair morphology

[Term]
id: MP:0006366
name: absent zigzag hairs
def: "absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0000402 ! abnormal zigzag hair morphology

[Term]
id: MP:0006367
name: absent sweat gland
def: "absence of any of the coil glands of the skin that secrete sweat" [MGI:llw2]
is_a: MP:0000674 ! abnormal sweat gland morphology

[Term]
id: MP:0006369
name: supernumerary incisors
def: "more than the usual number of incisors, normally consisting of two pairs, top and bottom, of the long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "increased incisor number" EXACT []
is_a: MP:0004033 ! supernumerary teeth
is_a: MP:0005358 ! abnormal incisor morphology

[Term]
id: MP:0006370
name: abnormal hair follicle pheomelanosome pheomelanin content
def: "anomaly in the amount or distribution of yellow pigment in the hair follicle" [https://orcid.org/0000-0003-4606-0597, MGI:llw2]
synonym: "abnormal agouti banding" RELATED []
synonym: "abnormal hair follicle phaeomelanosome phaeomelanin content" EXACT []
is_a: MP:0004381 ! abnormal hair follicle melanocyte morphology
is_a: MP:0013316 ! abnormal pheomelanosome pheomelanin content

[Term]
id: MP:0006371
name: absent hair follicle pheomelanosome pheomelanin
def: "yellow pigment is not present in pheomelanosomes of the hair follicle" [https://orcid.org/0000-0003-4606-0597, MGI:llw2]
synonym: "absent agouti banding" RELATED []
synonym: "absent hair follicle phaeomelanosome phaeomelanin" EXACT []
is_a: MP:0006370 ! abnormal hair follicle pheomelanosome pheomelanin content

[Term]
id: MP:0006372
name: impaired placental function
def: "reduction in the ability of the placenta to supply nutrients or remove waste" [https://orcid.org/0000-0003-4606-0597]
synonym: "placental dysfunction" EXACT []
synonym: "placental insufficiency" EXACT []
is_a: MP:0010038 ! abnormal placenta physiology

[Term]
id: MP:0006373
name: abnormal circulating angiotensinogen level
def: "anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal circulating angiotensin precursor level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level

[Term]
id: MP:0006374
name: obsolete abnormal blood osmolality
def: "OBSOLETE. anomaly in the concentration of ions in the blood" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true
replaced_by: MP:0008996

[Term]
id: MP:0006375
name: increased circulating angiotensinogen level
def: "greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006373 ! abnormal circulating angiotensinogen level
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0006376
name: decreased circulating angiotensinogen level
def: "less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating angiotensinogen level" EXACT []
is_a: MP:0006373 ! abnormal circulating angiotensinogen level
is_a: MP:0014502 ! decreased circulating protein level

[Term]
id: MP:0006377
name: abnormal vestibulocollic reflex
def: "any anomaly in the neural reflex which results from activation of afferents from the vestibular organs and uses neck movements to stabilize the head position in space" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal VCR" EXACT []
synonym: "abnormal vestibulo-collic reflex" EXACT []
is_a: MP:0001961 ! abnormal reflex
is_a: MP:0004742 ! abnormal vestibular system physiology

[Term]
id: MP:0006378
name: abnormal spermatogonia morphology
def: "any structural anomaly of the large unspecialized male germ cells that give rise to spermatocytes" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
synonym: "abnormal spermatogonium" EXACT []
is_a: MP:0006362 ! abnormal male germ cell morphology

[Term]
id: MP:0006379
name: abnormal spermatocyte morphology
def: "any structural anomaly of male germ cells that through meiosis give rise to spermatids" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0006362 ! abnormal male germ cell morphology

[Term]
id: MP:0006380
name: abnormal spermatid morphology
def: "any structural anomaly of the male germ cells that without further cell division give rise to mature spermatozoa" [https://orcid.org/0000-0003-4606-0597, ISBN:0803606559]
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0006362 ! abnormal male germ cell morphology

[Term]
id: MP:0006382
name: abnormal lung epithelium morphology
def: "any structural anomaly of the epithelial layer of the lung" [https://orcid.org/0000-0003-4606-0597, MGI:rbabiuk]
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0010942 ! abnormal respiratory epithelium morphology

[Term]
id: MP:0006383
name: abnormal cochlear frequency tuning
def: "any anomaly in the frequency resolution of the cochlea, normally determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells which detect and amplify sound-induced basilar membrane motions" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cochlear tuning" EXACT []
synonym: "abnormal frequency resolution of the cochlea" EXACT []
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0006384
name: enhanced cochlear frequency tuning
def: "increase in the sharpness of frequency resolution of the cochlea" [https://orcid.org/0000-0002-6490-7723]
synonym: "sharpened cochlear frequency tuning" EXACT []
is_a: MP:0006383 ! abnormal cochlear frequency tuning

[Term]
id: MP:0006386
name: absent somites
def: "absence of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001690 ! failure of somite differentiation

[Term]
id: MP:0006387
name: abnormal T cell number
def: "deviation from the normal count of T cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal T lymphocyte number" EXACT []
synonym: "abnormal T-cell number" EXACT []
is_a: MP:0000717 ! abnormal lymphocyte cell number
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0006388
name: abnormal auditory summating potential
def: "any anomaly in the dc shift in the waveform sustained for the duration of a toneburst stimulus that represents the depolarization of sensory hair cells in the cochlea; positive summating potentials (SPs) reflect activity of basal turn hair cells while negative SPs are derived from hair cell activity in the apical turn; negative SPs tend to be obtained at low frequencies and low intensities of stimulus, while positive SPs are recorded in response to high frequencies and high intensities" [https://orcid.org/0000-0003-3691-0324, PMID:1526886]
synonym: "abnormal SP" EXACT []
synonym: "abnormal summating potential" EXACT []
is_a: MP:0006335 ! abnormal hearing electrophysiology

[Term]
id: MP:0006389
name: abnormal vestibular endolymph physiology
def: "change in the normal production (volume) or ionic homeostasis of the fluid contained within the vestibule of the inner ear; unlike cochlear endolymph this fluid does not have a high potential" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004885 ! abnormal endolymph physiology

[Term]
id: MP:0006390
name: abnormal cochlear endolymph physiology
def: "change in the normal production (volume) or ionic homeostasis of the fluid contained within the cochlea of the inner ear" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004885 ! abnormal endolymph physiology

[Term]
id: MP:0006391
name: abnormal vestibular endolymph ionic homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the vestibular endolymph" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006389 ! abnormal vestibular endolymph physiology

[Term]
id: MP:0006392
name: abnormal nucleus pulposus morphology
def: "any structural anomaly of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" [MGI:llw2]
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0006393
name: absent nucleus pulposus
def: "missing the notochord remnant normally found in the center of the intervertebral disc" [MGI:llw2]
is_a: MP:0006392 ! abnormal nucleus pulposus morphology

[Term]
id: MP:0006394
name: abnormal vertebral epiphyseal plate morphology
def: "any structural anomaly of the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [https://orcid.org/0000-0003-4606-0597, ISBN:0-914294-08-3, MGI:llw2]
synonym: "abnormal vertebral epiphysial plate" EXACT []
synonym: "abnormal vertebral growth plate" EXACT []
is_a: MP:0005225 ! abnormal vertebrae development
is_a: MP:0006395 ! abnormal epiphyseal plate morphology

[Term]
id: MP:0006395
name: abnormal epiphyseal plate morphology
def: "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
synonym: "abnormal epiphyseal cartilage" EXACT []
synonym: "abnormal epiphysial plate morphology" EXACT []
synonym: "abnormal growth plate morphology" EXACT []
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0006396
name: decreased long bone epiphyseal plate size
def: "reduced size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced long bone epiphyseal plate size" EXACT []
synonym: "short long bone epiphyseal plate" EXACT []
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0006397
name: disorganized long bone epiphyseal plate
def: "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0006398
name: increased long bone epiphyseal plate size
def: "greater than the normal size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged long bone epiphyseal plate" EXACT []
synonym: "expanded long bone epiphyseal plate" EXACT []
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0006399
name: abnormal long bone epiphyseal ossification zone morphology
def: "any structural anomaly of the layer of the epiphyseal plate where new bone matrix is deposited" [http://137.222.110.150/calnet/Introanat/Introanat.htm, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003055 ! abnormal long bone epiphyseal plate morphology

[Term]
id: MP:0006400
name: decreased molar number
def: "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [https://orcid.org/0009-0005-7755-8314]
synonym: "reduced molar number" EXACT []
synonym: "reduced number of molars" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0030608 ! decreased tooth number

[Term]
id: MP:0006401
name: absent male preputial gland
def: "a lack of the sebaceous glands of the corona and neck of the glans penis" [https://orcid.org/0009-0005-7755-8314]
synonym: "absent male preputial glands" EXACT []
synonym: "absent Tyson's gland" EXACT []
synonym: "absent Tyson's glands" EXACT []
is_a: MP:0002717 ! abnormal male preputial gland morphology

[Term]
id: MP:0006402
name: small molars
def: "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0030088 ! microdontia

[Term]
id: MP:0006403
name: abnormal cochlear endolymph ionic homeostasis
def: "anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002630 ! abnormal endocochlear potential

[Term]
id: MP:0006404
name: abnormal lumbar dorsal root ganglion morphology
def: "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal lumbar dorsal root ganglia morphology" EXACT []
synonym: "abnormal lumbar DRG morphology" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0006405
name: abnormal L3 dorsal root ganglion morphology
def: "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the third lumbar vertebra" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal L3 dorsal root ganglia morphology" EXACT []
synonym: "abnormal L3 DRG morphology" EXACT []
is_a: MP:0006404 ! abnormal lumbar dorsal root ganglion morphology

[Term]
id: MP:0006408
name: dorsal root ganglion hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the dorsal root ganglion, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cellularity of dorsal root ganglion" EXACT []
synonym: "dorsal root ganglia hypoplasia" EXACT []
synonym: "DRG hypoplasia" EXACT []
is_a: MP:0000964 ! small dorsal root ganglion

[Term]
id: MP:0006409
name: vestibular ganglion hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the vestibular ganglion, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic Scarpa's ganglion" EXACT []
synonym: "Scarpa ganglion hypoplasia" EXACT []
is_a: MP:0003987 ! small vestibular ganglion

[Term]
id: MP:0006410
name: abnormal common myeloid progenitor cell morphology
def: "any structural anomaly of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cfu-gemm morphology" RELATED [ISBN:0878932437]
synonym: "abnormal CFU-S morphology" RELATED [ISBN:0878932437]
synonym: "abnormal CMPs" EXACT [ISBN:0878932437]
synonym: "abnormal colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte morphology" RELATED [ISBN:0878932437]
synonym: "abnormal multipotential myeloid stem cell morphology" RELATED [ISBN:0878932437]
synonym: "abnormal myeloid stem cell morphology" RELATED [ISBN:0878932437]
synonym: "abnormal pluripotent stem cell (bone marrow) morphology" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell abnormalities" EXACT []
is_a: MP:0002123 ! abnormal definitive hematopoiesis
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0006411
name: upturned snout
def: "muzzle has a curve or tilt such that the tip points upwards" [https://orcid.org/0000-0003-4606-0597, MGI:brs]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0006412
name: abnormal T cell apoptosis
def: "change in the timing or the number of T cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597, MGI:brs]
synonym: "abnormal T lymphocyte apoptosis" EXACT []
synonym: "abnormal T-cell apoptosis" EXACT []
synonym: "abnormal T-lymphocyte apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0006413
name: increased T cell apoptosis
def: "increase in the number of T cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597, MGI:brs]
synonym: "increased T lymphocyte apoptosis" EXACT []
synonym: "increased T-cell apoptosis" EXACT []
synonym: "increased T-lymphocyte apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0006412 ! abnormal T cell apoptosis

[Term]
id: MP:0006414
name: decreased T cell apoptosis
def: "decrease in the number of T cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased T lymphocyte apoptosis" EXACT []
synonym: "decreased T-cell apoptosis" EXACT []
synonym: "decreased T-lymphocyte apoptosis" EXACT []
synonym: "reduced T lymphocyte apoptosis" EXACT []
synonym: "reduced T-cell apoptosis" EXACT []
synonym: "reduced T-lymphocyte apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0006412 ! abnormal T cell apoptosis

[Term]
id: MP:0006415
name: absent testes
def: "absence of the male reproductive glands containing the germ cells" [https://orcid.org/0000-0002-6490-7723]
subset: Europhenome_Terms
subset: IMPC
synonym: "anorchia" NARROW []
synonym: "anorchidism" NARROW []
synonym: "anorchism" NARROW []
synonym: "bilateral testicular agenesis" NARROW []
synonym: "bilateral testicular aplasia" EXACT []
synonym: "congenital absence of both testes" NARROW []
synonym: "male agonadism" EXACT []
is_a: MP:0001146 ! abnormal testis morphology
is_a: MP:0005644 ! agonadal

[Term]
id: MP:0006416
name: abnormal rete testis morphology
def: "any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Haller rete" EXACT []
synonym: "abnormal rete halleri" EXACT []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0006417
name: rete testis obstruction
def: "any impediment or blockage of the network of canals at the termination of the straight tubules in the mediastinum testis" [https://orcid.org/0000-0002-6490-7723]
synonym: "blockade of rete testis" EXACT []
is_a: MP:0006416 ! abnormal rete testis morphology

[Term]
id: MP:0006418
name: abnormal testis cord formation
def: "any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal seminiferous cords" EXACT []
synonym: "abnormal testis cords" EXACT []
synonym: "defective testis cord formation" NARROW []
synonym: "impaired testis cord differentiation" NARROW []
synonym: "incomplete testis cord development" NARROW []
is_a: MP:0003830 ! abnormal testis development

[Term]
id: MP:0006419
name: disorganized testis cords
def: "derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [https://orcid.org/0000-0002-6490-7723]
synonym: "disorganised testis cords" EXACT []
is_a: MP:0006418 ! abnormal testis cord formation

[Term]
id: MP:0006420
name: abnormal peritubular myoid cell morphology
def: "any structural anomaly of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule" [https://orcid.org/0000-0002-6490-7723]
comment: During testis cord differentiation, PTM cells surround the testis cord, separating it from the peritubular space and contributing to the production of the basal lamina.
synonym: "abnormal peritubular contractile cells" EXACT []
synonym: "abnormal PTM cells" EXACT []
is_a: MP:0002216 ! abnormal seminiferous tubule morphology

[Term]
id: MP:0006421
name: decreased number of peritubular myoid cells
def: "reduced number of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced number of peritubular contractile cells" EXACT []
synonym: "reduced PTM cell numbers" EXACT []
is_a: MP:0006420 ! abnormal peritubular myoid cell morphology

[Term]
id: MP:0006422
name: increased mammary adenoacanthoma incidence
def: "higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9, MGI:rbabiuk]
synonym: "mammary adenoacanthoma" RELATED []
is_a: MP:0001883 ! increased mammary adenocarcinoma incidence

[Term]
id: MP:0006423
name: dilated rete testis
def: "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated retia testes" EXACT []
synonym: "rete testis dilation" EXACT []
is_a: MP:0006416 ! abnormal rete testis morphology

[Term]
id: MP:0006424
name: absent testis cords
def: "missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent seminiferous cords" EXACT []
is_a: MP:0006418 ! abnormal testis cord formation

[Term]
id: MP:0006425
name: absent Mullerian ducts
def: "absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent Meller ducts" EXACT []
synonym: "absent paramesonephric ducts" EXACT []
synonym: "Mullerian duct agenesis" EXACT []
synonym: "Mullerian duct aplasia" EXACT []
is_a: MP:0003826 ! abnormal Mullerian duct morphology

[Term]
id: MP:0006426
name: Mullerian duct degeneration
def: "a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "Muller duct degeneration" EXACT []
synonym: "paramesonephric duct degeneration" EXACT []
is_a: MP:0003826 ! abnormal Mullerian duct morphology

[Term]
id: MP:0006427
name: ectopic Leydig cells
def: "abnormal position of the testosterone-secreting cells normally found adjacent to the seminiferous tubules, within the interstitium of the testis" [https://orcid.org/0000-0002-6490-7723]
synonym: "heterotopic Leydig cells" EXACT []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0006428
name: ectopic Sertoli cells
def: "abnormal position of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "heterotopic Sertoli cells" EXACT []
is_a: MP:0002784 ! abnormal Sertoli cell morphology

[Term]
id: MP:0006429
name: abnormal hyaline cartilage morphology
def: "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9, MGI:rbabiuk]
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0006430
name: abnormal elastic cartilage morphology
def: "any structural anomaly of the nonvascular, resilient, flexible connective tissue containing elastin fibers; found primarily in the epiglottis, external ear, and auditory tubes" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9]
synonym: "abnormal yellow cartilage morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0006431
name: abnormal fibrocartilage morphology
def: "any structural anomaly of the nonvascular, resilient, flexible connective tissue containing thick bundles of collagenous fibers; found primarily in intervertebral disks" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9]
synonym: "abnormal fibrous cartilage morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology

[Term]
id: MP:0006432
name: abnormal costal cartilage morphology
def: "any structural anomaly of the nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9]
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0004624 ! abnormal thoracic cage morphology

[Term]
id: MP:0006433
name: abnormal articular cartilage morphology
def: "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9]
is_a: MP:0006429 ! abnormal hyaline cartilage morphology
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0008000
name: increased ovary tumor incidence
def: "greater than the expected number of neoplams in the ovary occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased ovarian tumor incidence" EXACT []
synonym: "increased ovarian tumour incidence" EXACT []
synonym: "increased ovary tumour incidence" EXACT []
synonym: "ovarian tumor" RELATED []
synonym: "ovarian tumour" RELATED []
is_a: MP:0001126 ! abnormal ovary morphology
is_a: MP:0009590 ! increased gonad tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0008001
name: hypochlorhydria
def: "reduced hydrochloric acid content of the gastric secretions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0008002
name: hyperchlorhydria
def: "increased hydrochloric acid content of the gastric secretions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0008003
name: achlorhydria
def: "absence of hydrochloric acid in the gastric secretions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0008004
name: abnormal stomach pH
def: "anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gastric pH" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology

[Term]
id: MP:0008005
name: decreased stomach pH
def: "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is increased, as indicated by the increased concentration of hydrogen ion" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced stomach pH" EXACT []
is_a: MP:0008004 ! abnormal stomach pH

[Term]
id: MP:0008006
name: increased stomach pH
def: "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [https://orcid.org/0000-0003-3691-0324]
synonym: "elevated stomach pH" EXACT []
is_a: MP:0008004 ! abnormal stomach pH

[Term]
id: MP:0008007
name: abnormal cellular replicative senescence
def: "anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [GO:0001302, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0008008
name: early cellular replicative senescence
def: "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [https://orcid.org/0000-0003-4606-0597]
synonym: "premature cellular replicative senescence" EXACT []
is_a: MP:0008007 ! abnormal cellular replicative senescence

[Term]
id: MP:0008009
name: delayed cellular replicative senescence
def: "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [https://orcid.org/0000-0003-4606-0597]
synonym: "late senescence" EXACT []
is_a: MP:0008007 ! abnormal cellular replicative senescence

[Term]
id: MP:0008010
name: increased gastric adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the stomach" [MGI:llw2]
synonym: "gastric adenocarcinoma" RELATED []
synonym: "stomach adenocarcinoma" RELATED []
is_a: MP:0009308 ! increased adenocarcinoma incidence
is_a: MP:0010301 ! increased stomach tumor incidence

[Term]
id: MP:0008011
name: intestine polyps
def: "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MESH:C23.300.825.411, MGI:llw2]
synonym: "intestinal polyposis" EXACT []
synonym: "intestinal polyps" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0010352 ! gastrointestinal tract polyps

[Term]
id: MP:0008012
name: duodenum polyps
def: "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2]
synonym: "duodenal polyposis" EXACT []
synonym: "duodenal polyps" EXACT []
is_a: MP:0003271 ! abnormal duodenum morphology
is_a: MP:0008011 ! intestine polyps

[Term]
id: MP:0008013
name: cecum polyps
def: "development of numerous growths that are connected to and protrude from the mucous membrane of the cecum" [MGI:llw2]
synonym: "caecum polyps" EXACT []
synonym: "cecal polyps" EXACT []
synonym: "cecum polyposis" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology
is_a: MP:0008011 ! intestine polyps

[Term]
id: MP:0008014
name: increased lung tumor incidence
def: "greater than the expected number of neoplasms in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:llw2]
synonym: "increased lung tumour incidence" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0010298 ! increased respiratory system tumor incidence

[Term]
id: MP:0008015
name: abnormal female inguinal canal morphology
def: "any structural anomaly of the passage in the lower abdominal wall through which the round ligament, nerves and vessels pass from the pelvic cavity to labia majora" [MGI:llw2]
is_a: MP:0001119 ! abnormal female reproductive system morphology
is_a: MP:0003673 ! abnormal inguinal canal morphology

[Term]
id: MP:0008016
name: abnormal male inguinal canal morphology
def: "any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels pass from the pelvic cavity to the scrotum" [MGI:llw2]
synonym: "abnormal male abdominal canal morphology" EXACT []
synonym: "abnormal male canalis inguinalis morphology" EXACT []
synonym: "abnormal male Velpeau canal morphology" EXACT []
is_a: MP:0001145 ! abnormal male reproductive system morphology
is_a: MP:0003673 ! abnormal inguinal canal morphology

[Term]
id: MP:0008017
name: inguinal cyst
def: "presence of one or more benign epithelial growths in the wall of the inguinal canal" [MGI:llw2]
synonym: "cystic inguinal canal" EXACT []
synonym: "inguinal canal cyst" EXACT []
synonym: "inguinal canal cysts" EXACT []
synonym: "inguinal cysts" EXACT []
is_a: MP:0003673 ! abnormal inguinal canal morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0008018
name: increased facial tumor incidence
def: "greater than the expected number of neoplasms on the face, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:llw2]
synonym: "increased facial tumour incidence" EXACT []
is_a: MP:0003743 ! abnormal facial morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence

[Term]
id: MP:0008019
name: increased liver tumor incidence
def: "greater than the expected number of neoplasms in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "increased hepatic tumor incidence" EXACT []
synonym: "increased hepatic tumour incidence" EXACT []
synonym: "increased liver tumour incidence" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0010297 ! increased hepatobiliary system tumor incidence

[Term]
id: MP:0008020
name: abnormal dermal mast cell morphology
def: "any structural anomaly of cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation" [MGI:llw2]
is_a: MP:0000359 ! abnormal mast cell morphology
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0008021
name: increased blastoma incidence
def: "higher than normal incidence of a fast growing and invasive tumor composed chiefly or entirely of immature undifferentiated cells that have embryonic characteristics resembling the primordium of the organ in which the tumor arose" [https://orcid.org/0000-0003-3691-0324]
synonym: "blastoma" RELATED []
is_a: MP:0002018 ! increased malignant tumor incidence

[Term]
id: MP:0008022
name: dilated heart ventricle
def: "the luminal space of one or both of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiac ventricle dilation" EXACT []
synonym: "cardiac ventricular dilation" EXACT []
synonym: "dilated cardiac ventricle" EXACT []
synonym: "dilated cardiac ventricles" EXACT []
synonym: "dilated heart ventricles" EXACT []
synonym: "heart ventricle dilation" EXACT []
synonym: "heart ventricular dilation" EXACT []
is_a: MP:0004937 ! dilated heart
is_a: MP:0005294 ! abnormal heart ventricle morphology

[Term]
id: MP:0008023
name: abnormal styloid process morphology
def: "any structural anomaly in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal processus styloideus ossis temporalis" EXACT []
synonym: "abnormal temporal bone styloid process morphology" EXACT []
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology

[Term]
id: MP:0008024
name: absent lymph nodes
def: "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0008025
name: brain vacuoles
def: "abnormal presence of fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [https://orcid.org/0000-0003-3691-0324]
synonym: "vacuoles in the brain" EXACT []
is_a: MP:0021002 ! brain lesion

[Term]
id: MP:0008026
name: abnormal brain white matter morphology
def: "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain alba morphology" EXACT []
synonym: "abnormal brain white substance morphology" EXACT []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0008027
name: abnormal spinal cord white matter morphology
def: "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal spinal cord alba morphology" EXACT []
synonym: "abnormal spinal cord white substance morphology" EXACT []
xref: MA:0000910
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0008028
name: pregnancy-related premature death
def: "death occurring before the normal life span of an organism, occurring during pregnancy, parturition or lactation" [https://orcid.org/0000-0003-3691-0324, MGI:hdene]
is_a: MP:0002083 ! premature death

[Term]
id: MP:0008029
name: abnormal paraxial mesoderm morphology
def: "any structural anomaly of the mesoderm located bilaterally adjacent to the notochord and neural tube; on segmentation, paraxial mesoderm forms the paired somites" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal paraxial mesenchyme morphology" EXACT []
synonym: "abnormal somitic mesoderm" EXACT []
is_a: MP:0006301 ! abnormal mesenchyme morphology
is_a: MP:0014141 ! abnormal mesoderm morphology

[Term]
id: MP:0008030
name: abnormal Cajal-Retzius cell morphology
def: "any structural anomaly of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000792 ! abnormal cortical marginal zone morphology
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0008031
name: decreased Cajal-Retzius cell number
def: "reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased number of Cajal-Retzius cells" EXACT []
synonym: "reduced Cajal-Retzius cell number" EXACT []
synonym: "reduced number of Cajal-Retzius cells" EXACT []
is_a: MP:0008030 ! abnormal Cajal-Retzius cell morphology
is_a: MP:0008948 ! decreased neuron number

[Term]
id: MP:0008032
name: abnormal lipolysis
def: "anomaly in the process of the hydrolysis of fat into free fatty acids" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lipoclasis" EXACT []
synonym: "abnormal lipodieresis" EXACT []
is_a: MP:0013245 ! abnormal lipid metabolism

[Term]
id: MP:0008033
name: impaired lipolysis
def: "reduction in the rate of the hydrolysis of fat into free fatty acids" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lipolysis" EXACT []
synonym: "reduced lipolysis" EXACT []
is_a: MP:0008032 ! abnormal lipolysis

[Term]
id: MP:0008034
name: enhanced lipolysis
def: "increase in the rate of the hydrolysis of fat into free fatty acids" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lipolysis" EXACT []
is_a: MP:0008032 ! abnormal lipolysis

[Term]
id: MP:0008035
name: behavioral arrest
def: "locomotor activity is interrupted by sudden periods of no movement" [MGI:llw2]
synonym: "behavioural arrest" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior

[Term]
id: MP:0008036
name: abnormal NK T cell morphology
def: "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
comment: Note that these are a distinct cell population from NK cells.
synonym: "abnormal natural killer T cell morphology" EXACT []
synonym: "abnormal natural killer T lymphocyte morphology" EXACT []
synonym: "abnormal natural killer T-cell morphology" EXACT []
synonym: "abnormal natural killer T-lymphocyte morphology" EXACT []
synonym: "abnormal natural T cell morphology" EXACT []
synonym: "abnormal NK T lymphocyte morphology" EXACT []
synonym: "abnormal NK T-cell morphology" EXACT []
synonym: "abnormal NK T-lymphocyte morphology" EXACT []
synonym: "abnormal NKT cell morphology" EXACT []
is_a: MP:0002435 ! abnormal effector T cell morphology
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology

[Term]
id: MP:0008037
name: abnormal T cell morphology
def: "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal T cell morphology/development" RELATED []
synonym: "abnormal T lymphocyte morphology" EXACT []
synonym: "abnormal T-cell morphology" EXACT []
synonym: "abnormal T-lymphocyte morphology" EXACT []
synonym: "abnormal thymocyte morphology" NARROW []
synonym: "T lymphocyte abnormalities" EXACT []
synonym: "T lymphocyte defects" EXACT []
synonym: "T-cell abnormalities" EXACT []
is_a: MP:0002619 ! abnormal lymphocyte morphology

[Term]
id: MP:0008038
name: abnormal NK T cell number
def: "deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
synonym: "abnormal natural killer T cell number" EXACT []
synonym: "abnormal natural killer T lymphocyte number" EXACT []
synonym: "abnormal natural killer T-cell number" EXACT []
synonym: "abnormal natural killer T-lymphocyte number" EXACT []
synonym: "abnormal natural T cell number" EXACT []
synonym: "abnormal NK T lymphocyte number" EXACT []
synonym: "abnormal NK T-cell number" EXACT []
synonym: "abnormal NK T-lymphocyte number" EXACT []
synonym: "abnormal NKT cell number" EXACT []
is_a: MP:0008036 ! abnormal NK T cell morphology
is_a: MP:0012763 ! abnormal alpha-beta T cell number
is_a: MP:0013762 ! abnormal effector T cell number

[Term]
id: MP:0008039
name: increased NK T cell number
def: "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
subset: IMPC
subset: Sanger_Terms
synonym: "increased natural killer T cell number" EXACT []
synonym: "increased natural killer T lymphocyte number" EXACT []
synonym: "increased natural killer T-cell number" EXACT []
synonym: "increased natural killer T-lymphocyte number" EXACT []
synonym: "increased natural T cell number" EXACT []
synonym: "increased NK T lymphocyte number" EXACT []
synonym: "increased NK T-cell number" EXACT []
synonym: "increased NK T-lymphocyte number" EXACT []
synonym: "increased NKT cell number" EXACT []
is_a: MP:0005015 ! increased T cell number
is_a: MP:0008038 ! abnormal NK T cell number

[Term]
id: MP:0008040
name: decreased NK T cell number
def: "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased natural killer T cell number" EXACT []
synonym: "decreased natural killer T lymphocyte number" EXACT []
synonym: "decreased natural killer T-cell number" EXACT []
synonym: "decreased natural killer T-lymphocyte number" EXACT []
synonym: "decreased natural T cell number" EXACT []
synonym: "decreased NK T lymphocyte number" EXACT []
synonym: "decreased NK T-cell number" EXACT []
synonym: "decreased NK T-lymphocyte number" EXACT []
synonym: "decreased NKT cell number" EXACT []
synonym: "reduced natural killer T cell number" EXACT []
synonym: "reduced natural killer T lymphocyte number" EXACT []
synonym: "reduced natural killer T-cell number" EXACT []
synonym: "reduced natural killer T-lymphocyte number" EXACT []
synonym: "reduced natural T cell number" EXACT []
synonym: "reduced NK T cell number" EXACT []
synonym: "reduced NK T lymphocyte number" EXACT []
synonym: "reduced NK T-cell number" EXACT []
synonym: "reduced NK T-lymphocyte number" EXACT []
synonym: "reduced NKT cell number" EXACT []
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0008038 ! abnormal NK T cell number

[Term]
id: MP:0008041
name: absent NK T cells
def: "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
synonym: "absent natural killer T cell" EXACT []
synonym: "absent natural killer T lymphocyte" EXACT []
synonym: "absent natural killer T-cell" EXACT []
synonym: "absent natural killer T-lymphocyte" EXACT []
synonym: "absent natural T cell" EXACT []
synonym: "absent NK T lymphocyte" EXACT []
synonym: "absent NK T-cell" EXACT []
synonym: "absent NK T-lymphocyte" EXACT []
synonym: "absent NKT cell" EXACT []
is_a: MP:0008040 ! decreased NK T cell number

[Term]
id: MP:0008042
name: abnormal NK T cell physiology
def: "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
synonym: "abnormal natural killer T cell physiology" EXACT []
synonym: "abnormal natural killer T lymphocyte physiology" EXACT []
synonym: "abnormal natural killer T-cell physiology" EXACT []
synonym: "abnormal natural killer T-lymphocyte physiology" EXACT []
synonym: "abnormal natural T cell physiology" EXACT []
synonym: "abnormal NK T lymphocyte physiology" EXACT []
synonym: "abnormal NK T-cell physiology" EXACT []
synonym: "abnormal NK T-lymphocyte physiology" EXACT []
synonym: "abnormal NKT cell physiology" EXACT []
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0008043
name: abnormal NK cell number
def: "deviation in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
synonym: "abnormal natural killer cell number" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0000717 ! abnormal lymphocyte cell number
is_a: MP:0005068 ! abnormal NK cell morphology

[Term]
id: MP:0008044
name: increased NK cell number
def: "greater number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased natural killer cell number" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0005013 ! increased lymphocyte cell number
is_a: MP:0008043 ! abnormal NK cell number

[Term]
id: MP:0008045
name: decreased NK cell number
def: "reduction in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased natural killer cell number" EXACT []
synonym: "reduced natural killer cell number" EXACT []
synonym: "reduced NK cell number" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0005016 ! decreased lymphocyte cell number
is_a: MP:0008043 ! abnormal NK cell number

[Term]
id: MP:0008046
name: absent NK cells
def: "absence of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
synonym: "absence of natural killer cells" EXACT []
synonym: "absent natural killer cells" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0008045 ! decreased NK cell number

[Term]
id: MP:0008047
name: absent uterine NK cells
def: "absence of a natural killer cell subset that is found in the decidua of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy" [PMID:14568979, PMID:19800965]
synonym: "absent decidual natural killer cells" EXACT []
synonym: "absent decidual NK cells" EXACT []
synonym: "absent dNK cells" EXACT []
synonym: "absent GMG cells" EXACT []
synonym: "absent granulated metrial gland cells" EXACT []
synonym: "absent uNK cells" EXACT []
synonym: "absent uterine natural killer cells" EXACT []
xref: CL:0002343
is_a: MP:0008876 ! decreased uterine NK cell number

[Term]
id: MP:0008048
name: abnormal memory T cell number
def: "deviation from the normal number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
synonym: "abnormal memory T lymphocyte number" EXACT []
synonym: "abnormal memory T-cell number" EXACT []
synonym: "abnormal memory T-lymphocyte number" EXACT []
xref: CL:0000813
is_a: MP:0006387 ! abnormal T cell number
is_a: MP:0010833 ! abnormal memory T cell morphology

[Term]
id: MP:0008049
name: increased memory T cell number
def: "increase in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
synonym: "increased memory T lymphocyte number" EXACT []
synonym: "increased memory T-cell number" EXACT []
synonym: "increased memory T-lymphocyte number" EXACT []
xref: CL:0000813
is_a: MP:0005015 ! increased T cell number
is_a: MP:0008048 ! abnormal memory T cell number

[Term]
id: MP:0008050
name: decreased memory T cell number
def: "reduction in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
synonym: "decreased memory T lymphocyte number" EXACT []
synonym: "decreased memory T-cell number" EXACT []
synonym: "decreased memory T-lymphocyte number" EXACT []
synonym: "reduced memory T cell number" EXACT []
synonym: "reduced memory T lymphocyte number" EXACT []
synonym: "reduced memory T-cell number" EXACT []
synonym: "reduced memory T-lymphocyte number" EXACT []
xref: CL:0000813
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0008048 ! abnormal memory T cell number

[Term]
id: MP:0008051
name: abnormal memory T cell physiology
def: "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [http://www.biology-online.org/, MGI:adiehl, MGI:rbabiuk]
is_a: MP:0002444 ! abnormal T cell physiology

[Term]
id: MP:0008052
name: abnormal serous gland morphology
def: "any structural anomaly of glands that secrete watery albuminous material that often contains enzymes" [ISBN:0-683-40008-8]
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0008053
name: abnormal NK cell differentiation
def: "atypical production of or inability to produce mature lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
synonym: "abnormal natural killer cell differentiation" EXACT []
is_a: MP:0002401 ! abnormal lymphopoiesis
is_a: MP:0005068 ! abnormal NK cell morphology

[Term]
id: MP:0008054
name: abnormal uterine NK cell morphology
def: "any structural anomaly of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy" [PMID:14568979, PMID:19800965]
comment: Granulated metrial gland cells are found in rodents and other species, but not in primates. The human equivalent of these cells has been described as uterine NK-cells, endometrial granulocytes or K cells.
synonym: "abnormal decidual natural killer cell morphology" EXACT []
synonym: "abnormal decidual NK cell morphology" EXACT []
synonym: "abnormal dNK cell morphology" EXACT []
synonym: "abnormal GMG cell morphology" EXACT []
synonym: "abnormal granulated metrial gland cell morphology" EXACT []
synonym: "abnormal uNK cell morphology" EXACT []
synonym: "abnormal uterine natural killer cell morphology" EXACT []
xref: CL:0002343
is_a: MP:0005068 ! abnormal NK cell morphology
is_a: MP:0010776 ! abnormal placenta metrial gland morphology

[Term]
id: MP:0008055
name: increased urine osmolality
def: "increase in the amount of ions in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002987 ! abnormal urine osmolality

[Term]
id: MP:0008056
name: abnormal retina ganglion cell morphology
def: "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal retinal ganglion cell morphology" EXACT []
is_a: MP:0000965 ! abnormal sensory neuron morphology
is_a: MP:0005241 ! abnormal retina ganglion layer morphology

[Term]
id: MP:0008057
name: abnormal DNA replication
def: "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
xref: GO:0006260
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0008058
name: abnormal DNA repair
def: "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
xref: GO:0006281
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0008059
name: abnormal podocyte foot process morphology
def: "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8]
synonym: "abnormal podocyte footplate morphology" EXACT []
synonym: "abnormal podocyte pedicel morphology" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology

[Term]
id: MP:0008060
name: abnormal podocyte slit diaphragm morphology
def: "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008062 ! abnormal podocyte slit junction morphology

[Term]
id: MP:0008061
name: absent podocyte slit diaphragm
def: "absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008060 ! abnormal podocyte slit diaphragm morphology

[Term]
id: MP:0008062
name: abnormal podocyte slit junction morphology
def: "any structural anomaly of the gaps between the interdigitated foot processes of the podocyte" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal podocyte filtration slit" EXACT []
synonym: "abnormal podocyte slit pore" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology

[Term]
id: MP:0008063
name: increased otic epithelial cell apoptosis
def: "increase in the number of otic epithelial cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0009806 ! abnormal otic vesicle morphology

[Term]
id: MP:0008064
name: decreased otic epithelial cell proliferation
def: "reduction in the expansion rate of the otic epithelial cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased otic epithelium proliferation" BROAD []
synonym: "reduced otic epithelial cell proliferation" EXACT []
synonym: "reduced otic epithelium proliferation" BROAD []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009806 ! abnormal otic vesicle morphology

[Term]
id: MP:0008065
name: short endolymphatic duct
def: "length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [https://orcid.org/0000-0002-6490-7723]
synonym: "truncated endolymphatic duct" EXACT []
is_a: MP:0008066 ! small endolymphatic duct

[Term]
id: MP:0008066
name: small endolymphatic duct
def: "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0008067
name: retina ganglion cell degeneration
def: "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "retinal ganglion cell degeneration" EXACT []
is_a: MP:0003224 ! neuron degeneration
is_a: MP:0008056 ! abnormal retina ganglion cell morphology

[Term]
id: MP:0008068
name: absent retina ganglion cell
def: "absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent retinal ganglion cell" EXACT []
is_a: MP:0006309 ! decreased retina ganglion cell number

[Term]
id: MP:0008069
name: abnormal joint mobility
def: "anomaly in the ability to move joints in a full range of motion and with ease" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0031169 ! abnormal joint physiology

[Term]
id: MP:0008070
name: absent T cells
def: "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005018 ! decreased T cell number

[Term]
id: MP:0008071
name: absent B cells
def: "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005017 ! decreased B cell number

[Term]
id: MP:0008072
name: absent double-negative T cells
def: "absence of the subset of T cells found in the thymus that express neither CD4 nor CD8" [ISBN:0-8153-1691-7]
synonym: "absent double negative T cells" EXACT []
is_a: MP:0005089 ! decreased double-negative T cell number

[Term]
id: MP:0008073
name: abnormal CD4-positive, alpha-beta T cell number
def: "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
synonym: "abnormal CD4+ T cell number" EXACT []
synonym: "abnormal CD4-positive T cell number" EXACT []
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology
is_a: MP:0012763 ! abnormal alpha-beta T cell number

[Term]
id: MP:0008074
name: increased CD4-positive, alpha-beta T cell number
def: "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased CD4+ T cell number" EXACT []
synonym: "increased CD4-positive T cell number" EXACT []
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0012764 ! increased alpha-beta T cell number

[Term]
id: MP:0008075
name: decreased CD4-positive, alpha-beta T cell number
def: "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased CD4+ T cell number" EXACT []
synonym: "decreased CD4-positive T cell number" EXACT []
synonym: "reduced CD4+ T cell number" EXACT []
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0012765 ! decreased alpha-beta T cell number

[Term]
id: MP:0008076
name: abnormal CD4-positive T cell differentiation
def: "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CD4+ T cell differentiation" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology

[Term]
id: MP:0008077
name: abnormal CD8-positive, alpha-beta T cell number
def: "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
synonym: "abnormal CD8+ T cell number" EXACT []
synonym: "abnormal CD8-positive T cell number" EXACT []
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology
is_a: MP:0012763 ! abnormal alpha-beta T cell number

[Term]
id: MP:0008078
name: increased CD8-positive, alpha-beta T cell number
def: "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased CD8+ T cell number" EXACT []
synonym: "increased CD8-positive T cell number" EXACT []
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number
is_a: MP:0012764 ! increased alpha-beta T cell number

[Term]
id: MP:0008079
name: decreased CD8-positive, alpha-beta T cell number
def: "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [https://orcid.org/0000-0003-3691-0324]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased CD8+ T cell number" EXACT []
synonym: "decreased CD8-positive T cell number" EXACT []
synonym: "reduced CD8+ T cell number" EXACT []
synonym: "reduced CD8-positive T cell number" EXACT []
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number
is_a: MP:0012765 ! decreased alpha-beta T cell number

[Term]
id: MP:0008080
name: abnormal CD8-positive, alpha-beta T cell differentiation
def: "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CD8+ T cell differentiation" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology

[Term]
id: MP:0008081
name: abnormal single-positive T cell number
def: "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal single positive T cell number" EXACT []
is_a: MP:0002435 ! abnormal effector T cell morphology

[Term]
id: MP:0008082
name: increased single-positive T cell number
def: "greater number of T cells bearing either CD4 or CD8 markers on their surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased single positive T cell number" EXACT []
is_a: MP:0005015 ! increased T cell number
is_a: MP:0008081 ! abnormal single-positive T cell number

[Term]
id: MP:0008083
name: decreased single-positive T cell number
def: "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased single positive T cell number" EXACT []
synonym: "reduced single positive T cell number" EXACT []
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0008081 ! abnormal single-positive T cell number

[Term]
id: MP:0008084
name: obsolete absent single-positive T cells
def: "absence of T cells bearing either CD4 or CD8 markers on their surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent single positive T cells" EXACT []
is_obsolete: true
replaced_by: MP:0013276

[Term]
id: MP:0008085
name: abnormal T-helper 1 cell number
def: "anomaly in the number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
synonym: "abnormal helper T cell type 1 cell number" EXACT []
synonym: "abnormal helper T lymphocyte type 1 cell number" EXACT []
synonym: "abnormal helper T-cell type 1 cell number" EXACT []
synonym: "abnormal helper T-lymphocyte type 1 cell number" EXACT []
synonym: "abnormal T helper 1 cell number" EXACT []
synonym: "abnormal TH1 cell number" EXACT []
synonym: "T helper 1 cell number abnormalities" EXACT []
synonym: "TH1 cell number abnormalities" EXACT []
synonym: "Th1 cell number abnormalities" EXACT []
is_a: MP:0002433 ! abnormal T-helper 1 cell morphology
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0008086
name: increased T-helper 1 cell number
def: "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
synonym: "increased helper T cell type 1 cell number" EXACT []
synonym: "increased helper T lymphocyte type 1 cell number" EXACT []
synonym: "increased helper T-cell type 1 cell number" EXACT []
synonym: "increased helper T-lymphocyte type 1 cell number" EXACT []
synonym: "increased T helper 1 cell number" EXACT []
synonym: "increased TH1 cell number" EXACT []
synonym: "increased Th1 cell number" EXACT []
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0008085 ! abnormal T-helper 1 cell number
is_a: MP:0013763 ! increased T-helper cell number

[Term]
id: MP:0008087
name: decreased T helper 1 cell number
def: "reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased helper T cell type 1 cell number" EXACT []
synonym: "decreased helper T lymphocyte type 1 cell number" EXACT []
synonym: "decreased helper T-cell type 1 cell number" EXACT []
synonym: "decreased helper T-lymphocyte type 1 cell number" EXACT []
synonym: "decreased TH1 cell number" EXACT []
synonym: "decreased Th1 cell number" EXACT []
synonym: "reduced helper T cell type 1 cell number" EXACT []
synonym: "reduced helper T lymphocyte type 1 cell number" EXACT []
synonym: "reduced helper T-cell type 1 cell number" EXACT []
synonym: "reduced helper T-lymphocyte type 1 cell number" EXACT []
synonym: "reduced T helper 1 cell number" EXACT []
synonym: "reduced TH1 cell number" EXACT []
synonym: "reduced Th1 cell number" EXACT []
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0008085 ! abnormal T-helper 1 cell number
is_a: MP:0013764 ! decreased T-helper cell number

[Term]
id: MP:0008088
name: abnormal T-helper 1 cell differentiation
def: "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal helper T cell type 1 cell differentiation" EXACT []
synonym: "abnormal helper T lymphocyte type 1 cell differentiation" EXACT []
synonym: "abnormal helper T-cell type 1 cell differentiation" EXACT []
synonym: "abnormal helper T-lymphocyte type 1 cell differentiation" EXACT []
synonym: "abnormal T helper 1 cell differentiation" EXACT []
synonym: "abnormal TH1 cell differentiation" EXACT []
synonym: "abnormal Th1 cell differentiation" EXACT []
is_a: MP:0002433 ! abnormal T-helper 1 cell morphology
is_a: MP:0008076 ! abnormal CD4-positive T cell differentiation

[Term]
id: MP:0008089
name: abnormal T-helper 2 cell number
def: "anomaly in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal helper T cell type 2 cell number" EXACT []
synonym: "abnormal helper T lymphocyte type 2 cell number" EXACT []
synonym: "abnormal helper T-cell type 2 cell number" EXACT []
synonym: "abnormal helper T-lymphocyte type 2 cell number" EXACT []
synonym: "abnormal T helper 2 cell number" EXACT []
synonym: "abnormal TH2 cell number" EXACT []
synonym: "T helper 2 cell number abnormalities" EXACT []
synonym: "TH2 cell number abnormalities" EXACT []
synonym: "Th2 cell number abnormalities" EXACT []
is_a: MP:0002434 ! abnormal T-helper 2 cell morphology
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0008090
name: increased T-helper 2 cell number
def: "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "increased helper T cell type 2 cell number" EXACT []
synonym: "increased helper T lymphocyte type 2 cell number" EXACT []
synonym: "increased helper T-cell type 2 cell number" EXACT []
synonym: "increased helper T-lymphocyte type 2 cell number" EXACT []
synonym: "increased T helper 2 cell number" EXACT []
synonym: "increased TH2 cell number" EXACT []
synonym: "increased Th2 cell number" EXACT []
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0008089 ! abnormal T-helper 2 cell number
is_a: MP:0013763 ! increased T-helper cell number

[Term]
id: MP:0008091
name: decreased T-helper 2 cell number
def: "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "decreased helper T cell type 2 cell number" EXACT []
synonym: "decreased helper T lymphocyte type 2 cell number" EXACT []
synonym: "decreased helper T-cell type 2 cell number" EXACT []
synonym: "decreased helper T-lymphocyte type 2 cell number" EXACT []
synonym: "decreased T helper 2 cell number" EXACT []
synonym: "decreased TH2 cell number" EXACT []
synonym: "decreased Th2 cell number" EXACT []
synonym: "reduced helper T cell type 2 cell number" EXACT []
synonym: "reduced helper T lymphocyte type 2 cell number" EXACT []
synonym: "reduced helper T-cell type 2 cell number" EXACT []
synonym: "reduced helper T-lymphocyte type 2 cell number" EXACT []
synonym: "reduced T helper 2 cell number" EXACT []
synonym: "reduced TH2 cell number" EXACT []
synonym: "reduced Th2 cell number" EXACT []
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0008089 ! abnormal T-helper 2 cell number
is_a: MP:0013764 ! decreased T-helper cell number

[Term]
id: MP:0008092
name: abnormal T-helper 2 cell differentiation
def: "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal helper T cell type 2 cell differentiation" EXACT []
synonym: "abnormal helper T lymphocyte type 2 cell differentiation" EXACT []
synonym: "abnormal helper T-cell type 2 cell differentiation" EXACT []
synonym: "abnormal helper T-lymphocyte type 2 cell differentiation" EXACT []
synonym: "abnormal T helper 2 cell differentiation" EXACT []
synonym: "abnormal TH2 cell differentiation" EXACT []
synonym: "abnormal Th2 cell differentiation" EXACT []
is_a: MP:0002434 ! abnormal T-helper 2 cell morphology
is_a: MP:0008076 ! abnormal CD4-positive T cell differentiation

[Term]
id: MP:0008093
name: abnormal memory B cell number
def: "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002440 ! abnormal memory B cell morphology
is_a: MP:0002458 ! abnormal B cell number

[Term]
id: MP:0008094
name: absent memory B cells
def: "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008729 ! decreased memory B cell number

[Term]
id: MP:0008095
name: abnormal memory B cell differentiation
def: "atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002144 ! abnormal B cell differentiation
is_a: MP:0002440 ! abnormal memory B cell morphology

[Term]
id: MP:0008096
name: abnormal plasma cell number
def: "anomaly in the number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal plasmacyte cell number" EXACT []
is_a: MP:0002439 ! abnormal plasma cell morphology

[Term]
id: MP:0008097
name: increased plasma cell number
def: "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "plasma cell hyperplasia" EXACT []
is_a: MP:0008096 ! abnormal plasma cell number
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0008098
name: decreased plasma cell number
def: "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "reduced plasma cell number" EXACT []
is_a: MP:0008096 ! abnormal plasma cell number
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008099
name: abnormal plasma cell differentiation
def: "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002144 ! abnormal B cell differentiation
is_a: MP:0002439 ! abnormal plasma cell morphology

[Term]
id: MP:0008100
name: absent plasma cells
def: "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "absent plasmacyte" EXACT []
is_a: MP:0008098 ! decreased plasma cell number

[Term]
id: MP:0008101
name: lymph node hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lymph nodes, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lymph node cellularity" EXACT []
synonym: "hypoplastic lymph nodes" EXACT []
is_a: MP:0002217 ! small lymph nodes

[Term]
id: MP:0008102
name: lymph node hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lymph nodes, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic lymph nodes" EXACT []
synonym: "increased lymph node cellularity" EXACT []
is_a: MP:0000702 ! enlarged lymph nodes

[Term]
id: MP:0008103
name: amacrine cell degeneration
def: "a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "amacrine neuron degeneration" EXACT []
is_a: MP:0003224 ! neuron degeneration
is_a: MP:0005240 ! abnormal amacrine cell morphology

[Term]
id: MP:0008104
name: abnormal amacrine cell number
def: "anomaly in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal amacrine neuron number" EXACT []
is_a: MP:0005240 ! abnormal amacrine cell morphology

[Term]
id: MP:0008105
name: increased amacrine cell number
def: "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006006 ! increased sensory neuron number
is_a: MP:0008104 ! abnormal amacrine cell number

[Term]
id: MP:0008106
name: decreased amacrine cell number
def: "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced amacrine cell number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0008104 ! abnormal amacrine cell number

[Term]
id: MP:0008107
name: absent retina horizontal cells
def: "absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent horizontal cells" EXACT []
synonym: "absent retinal horizontal cells" EXACT []
is_a: MP:0006068 ! abnormal retina horizontal cell morphology

[Term]
id: MP:0008108
name: abnormal small intestinal villus morphology
def: "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [https://orcid.org/0000-0003-3691-0324, MGI:rbabiuk]
synonym: "abnormal small intestinal villi" EXACT []
is_a: MP:0000496 ! abnormal small intestine morphology

[Term]
id: MP:0008109
name: abnormal small intestinal microvillus morphology
def: "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [https://orcid.org/0000-0003-3691-0324, MGI:rbabiuk]
synonym: "abnormal small intestinal microvilli" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0008111
name: abnormal granulocyte differentiation
def: "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal granulopoiesis" EXACT []
is_a: MP:0001601 ! abnormal myelopoiesis
is_a: MP:0002441 ! abnormal granulocyte morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0008112
name: abnormal monocyte differentiation
def: "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001601 ! abnormal myelopoiesis
is_a: MP:0002445 ! abnormal mononuclear cell differentiation
is_a: MP:0002620 ! abnormal monocyte morphology

[Term]
id: MP:0008113
name: abnormal macrophage differentiation
def: "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002445 ! abnormal mononuclear cell differentiation
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0008114
name: abnormal Kupffer cell morphology
def: "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal Kupffer's cell" EXACT []
is_a: MP:0002446 ! abnormal macrophage morphology
is_a: MP:0008989 ! abnormal liver sinusoid morphology

[Term]
id: MP:0008115
name: abnormal dendritic cell differentiation
alt_id: MP:0008116
def: "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal dendritic cell maturation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0005460 ! abnormal leukopoiesis
is_a: MP:0005461 ! abnormal dendritic cell morphology

[Term]
id: MP:0008117
name: abnormal Langerhans cell morphology
def: "any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0006173 ! abnormal myeloid dendritic cell morphology

[Term]
id: MP:0008118
name: absent Langerhans cell
def: "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008119 ! decreased Langerhans cell number

[Term]
id: MP:0008119
name: decreased Langerhans cell number
def: "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "decreased number of Langerhans cells" EXACT []
synonym: "reduced Langerhans cell number" EXACT []
synonym: "reduced number of Langerhans cells" EXACT []
is_a: MP:0008122 ! decreased myeloid dendritic cell number
is_a: MP:0013411 ! abnormal Langerhans cell number

[Term]
id: MP:0008120
name: abnormal myeloid dendritic cell number
def: "anomaly in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [https://orcid.org/0000-0003-3691-0324, PMID:10449155, PMID:9521319]
is_a: MP:0006173 ! abnormal myeloid dendritic cell morphology
is_a: MP:0008125 ! abnormal dendritic cell number

[Term]
id: MP:0008121
name: increased myeloid dendritic cell number
def: "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
is_a: MP:0008120 ! abnormal myeloid dendritic cell number
is_a: MP:0008126 ! increased dendritic cell number

[Term]
id: MP:0008122
name: decreased myeloid dendritic cell number
def: "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
synonym: "reduced myeloid dendritic cell number" EXACT []
is_a: MP:0008120 ! abnormal myeloid dendritic cell number
is_a: MP:0008127 ! decreased dendritic cell number

[Term]
id: MP:0008123
name: abnormal plasmacytoid dendritic cell number
def: "anomaly in the number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [https://orcid.org/0000-0003-3691-0324, PMID:15596797]
synonym: "abnormal DC2 cell number" EXACT []
synonym: "abnormal lymphoid dendritic cell number" EXACT []
synonym: "abnormal PDC cell number" EXACT []
synonym: "abnormal pDC cell number" EXACT []
synonym: "abnormal plasmacytoid monocytes cell number" EXACT []
synonym: "abnormal plasmacytoid T cell number" EXACT []
synonym: "abnormal T-associated plasma cells cell number" EXACT []
is_a: MP:0004242 ! abnormal plasmacytoid dendritic cell morphology
is_a: MP:0008125 ! abnormal dendritic cell number

[Term]
id: MP:0008124
name: decreased plasmacytoid dendritic cell number
def: "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [https://orcid.org/0000-0003-3691-0324, PMID:15596797]
synonym: "decreased DC2 cell number" EXACT []
synonym: "decreased lymphoid dendritic cell number" EXACT []
synonym: "decreased PDC cell number" EXACT []
synonym: "decreased pDC cell number" EXACT []
synonym: "decreased plasmacytoid monocytes cell number" EXACT []
synonym: "decreased plasmacytoid T cell number" EXACT []
synonym: "decreased T-associated plasma cells cell number" EXACT []
synonym: "reduced DC2 cell number" EXACT []
synonym: "reduced lymphoid dendritic cell number" EXACT []
synonym: "reduced PDC cell number" EXACT []
synonym: "reduced pDC cell number" EXACT []
synonym: "reduced plasmacytoid dendritic cell number" EXACT []
synonym: "reduced plasmacytoid monocytes cell number" EXACT []
synonym: "reduced plasmacytoid T cell number" EXACT []
synonym: "reduced T-associated plasma cells cell number" EXACT []
is_a: MP:0000221 ! decreased leukocyte cell number
is_a: MP:0008123 ! abnormal plasmacytoid dendritic cell number
is_a: MP:0008127 ! decreased dendritic cell number

[Term]
id: MP:0008125
name: abnormal dendritic cell number
def: "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0005461 ! abnormal dendritic cell morphology

[Term]
id: MP:0008126
name: increased dendritic cell number
def: "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008125 ! abnormal dendritic cell number
is_a: MP:0011181 ! increased hematopoietic cell number

[Term]
id: MP:0008127
name: decreased dendritic cell number
def: "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "reduced dendritic cell number" EXACT []
is_a: MP:0008125 ! abnormal dendritic cell number
is_a: MP:0011182 ! decreased hematopoietic cell number

[Term]
id: MP:0008128
name: abnormal brain internal capsule morphology
def: "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: This structure is NOT part of the basal ganglia or striatum.
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal internal capsule of telencephalon morphology" EXACT [UBERON:0001887]
is_a: MP:0008026 ! abnormal brain white matter morphology

[Term]
id: MP:0008129
name: absent brain internal capsule
def: "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent internal capsule of telencephalon" EXACT []
is_a: MP:0008128 ! abnormal brain internal capsule morphology

[Term]
id: MP:0008130
name: abnormal pituitary intermediate lobe morphology
def: "any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [https://orcid.org/0000-0003-3691-0324]
synonym: "intermediate part of adenohypophysis" EXACT []
synonym: "Pars intermedia" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology

[Term]
id: MP:0008131
name: abnormal Peyer's patch number
def: "anomaly in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
synonym: "abnormal number of Peyer's patches" EXACT []
is_a: MP:0000696 ! abnormal Peyer's patch morphology

[Term]
id: MP:0008132
name: increased Peyer's patch number
def: "greater number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
synonym: "increased number of Peyer's patches" EXACT []
is_a: MP:0008131 ! abnormal Peyer's patch number

[Term]
id: MP:0008133
name: decreased Peyer's patch number
def: "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
synonym: "decreased number of Peyer's patches" EXACT []
synonym: "reduced Peyer's patch number" EXACT []
is_a: MP:0008131 ! abnormal Peyer's patch number

[Term]
id: MP:0008134
name: abnormal Peyer's patch size
def: "anomaly in the size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
is_a: MP:0000696 ! abnormal Peyer's patch morphology

[Term]
id: MP:0008135
name: small Peyer's patches
def: "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
synonym: "decreased Peyer's patch size" EXACT []
synonym: "reduced Peyer's patch size" EXACT []
is_a: MP:0008134 ! abnormal Peyer's patch size

[Term]
id: MP:0008136
name: enlarged Peyer's patches
def: "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [PMID:15841100]
synonym: "increased Peyer's patch size" EXACT []
is_a: MP:0008134 ! abnormal Peyer's patch size

[Term]
id: MP:0008137
name: absent podocytes
def: "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8]
is_a: MP:0011753 ! decreased podocyte number

[Term]
id: MP:0008138
name: absent podocyte foot process
def: "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8]
is_a: MP:0008059 ! abnormal podocyte foot process morphology

[Term]
id: MP:0008139
name: fused podocyte foot processes
def: "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8]
synonym: "fusion of podocyte foot processes" EXACT []
synonym: "podocyte foot processes fusion" EXACT []
is_a: MP:0008059 ! abnormal podocyte foot process morphology

[Term]
id: MP:0008140
name: podocyte foot process effacement
def: "a podocyte reaction to injury or damage characterized by flattening of foot processes due to gradual simplification of the interdigitating foot process; the whole podocyte looks flat due to retraction, widening, and shortening of the processes of each podocyte while the frequency of filtration slits is reduced, giving the appearance of a continuous cytoplasmic sheet covering the glomerular basement membrane" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008059 ! abnormal podocyte foot process morphology

[Term]
id: MP:0008141
name: decreased small intestinal microvillus size
def: "reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [https://orcid.org/0000-0003-3691-0324, MGI:rbabiuk]
synonym: "reduced small intestinal microvillus size" EXACT []
is_a: MP:0008109 ! abnormal small intestinal microvillus morphology

[Term]
id: MP:0008142
name: decreased small intestinal villus size
def: "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [https://orcid.org/0000-0003-3691-0324, MGI:rbabiuk]
synonym: "reduced small intestinal villus size" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0008143
name: abnormal dendrite morphology
def: "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [https://orcid.org/0000-0003-3691-0324, MGI:rbabiuk]
synonym: "abnormal dendritic arbor" EXACT []
synonym: "abnormal dendritic tree" EXACT []
is_a: MP:0008415 ! abnormal neurite morphology

[Term]
id: MP:0008144
name: nyctalopia
alt_id: MP:0006146
def: "decreased ability to see clearly in reduced illumination; often due to a deficiency of vitamin A or to a retinal disorder" [ISBN:0-683-40008-8, NCBI:matt]
synonym: "night blindness" EXACT []
synonym: "nocturnal amblyopia" EXACT []
synonym: "nyctanopia" EXACT []
is_a: MP:0002001 ! blindness

[Term]
id: MP:0008145
name: hemeralopia
def: "reduced ability to see clearly in bright light with night vision remaining unchanged; often due to impaired retinal cone function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "day blindness" EXACT []
synonym: "hemeranopia" EXACT []
is_a: MP:0002090 ! abnormal vision

[Term]
id: MP:0008146
name: asymmetric sternocostal joints
def: "loss of bilateral symmetry in rib attachments to the sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "asymmetric rib-sternum attachment" EXACT []
is_a: MP:0000155 ! asymmetric rib joints
is_a: MP:0008148 ! abnormal sternocostal joint morphology

[Term]
id: MP:0008147
name: asymmetric costovertebral joints
def: "loss of bilateral symmetry in rib attachments to the vertebral column" [https://orcid.org/0000-0003-3691-0324]
synonym: "asymmetric rib-vertebral column attachment" EXACT []
is_a: MP:0000155 ! asymmetric rib joints
is_a: MP:0008149 ! abnormal costovertebral joint morphology

[Term]
id: MP:0008148
name: abnormal sternocostal joint morphology
def: "any anomaly in the normal joining of the ribs to the sternum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal rib-sternum attachment" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology
is_a: MP:0004625 ! abnormal rib joint morphology
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0008149
name: abnormal costovertebral joint morphology
def: "any anomaly in the normal joining of the ribs to the vertebral column, these connections are made by costovertebral ligaments between the head of the rib and the body of the thoracic vertebra" [http://www.scientificspine.com/spinal-anatomy/thoracic-spine-anatomy.html, https://orcid.org/0000-0003-3691-0324, UBERON:0002292]
synonym: "abnormal costovertebral articulation" EXACT []
synonym: "abnormal rib-vertebral column attachment" EXACT []
is_a: MP:0004625 ! abnormal rib joint morphology
is_a: MP:0004703 ! abnormal vertebral column morphology
is_a: MP:0030804 ! abnormal synovial joint morphology

[Term]
id: MP:0008150
name: decreased diameter of long bones
def: "reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased periosteal diameter of long bones" EXACT []
synonym: "reduced diameter of long bones" EXACT []
synonym: "reduced periosteal diameter of long bones" EXACT []
synonym: "thin long bones" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0008151
name: increased diameter of long bones
def: "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased periosteal diameter of long bones" EXACT []
synonym: "thick long bones" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology

[Term]
id: MP:0008152
name: decreased diameter of femur
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of femur" EXACT []
synonym: "decreased periosteal diameter of femur" EXACT []
synonym: "reduced diameter of femur" EXACT []
synonym: "reduced outer diameter of femur" EXACT []
synonym: "reduced periosteal diameter of femur" EXACT []
synonym: "thin femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008153
name: decreased diameter of fibula
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of fibula" EXACT []
synonym: "decreased periosteal diameter of fibula" EXACT []
synonym: "reduced diameter of fibula" EXACT []
synonym: "reduced outer diameter of fibula" EXACT []
synonym: "reduced periosteal diameter of fibula" EXACT []
synonym: "thin fibula" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008154
name: decreased diameter of humerus
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of humerus" EXACT []
synonym: "decreased periosteal diameter of humerus" EXACT []
synonym: "reduced diameter of humerus" EXACT []
synonym: "reduced outer diameter of humerus" EXACT []
synonym: "reduced periosteal diameter of humerus" EXACT []
synonym: "thin humerus" EXACT []
is_a: MP:0005296 ! abnormal humerus morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008155
name: decreased diameter of radius
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of radius" EXACT []
synonym: "decreased periosteal diameter of radius" EXACT []
synonym: "reduced diameter of radius" EXACT []
synonym: "reduced outer diameter of radius" EXACT []
synonym: "reduced periosteal diameter of radius" EXACT []
synonym: "thin radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008156
name: decreased diameter of tibia
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of tibia" EXACT []
synonym: "decreased periosteal diameter of tibia" EXACT []
synonym: "reduced diameter of tibia" EXACT []
synonym: "reduced outer diameter of tibia" EXACT []
synonym: "reduced periosteal diameter of tibia" EXACT []
synonym: "thin tibia" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008157
name: decreased diameter of ulna
def: "reduced width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased outer diameter of ulna" EXACT []
synonym: "decreased periosteal diameter of ulna" EXACT []
synonym: "reduced diameter of ulna" EXACT []
synonym: "reduced outer diameter of ulna" EXACT []
synonym: "reduced periosteal diameter of ulna" EXACT []
synonym: "thin ulna" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology
is_a: MP:0008150 ! decreased diameter of long bones

[Term]
id: MP:0008158
name: increased diameter of femur
def: "increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of femur" EXACT []
synonym: "increased periosteal diameter of femur" EXACT []
synonym: "thick femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008159
name: increased diameter of fibula
def: "increased width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of fibula" EXACT []
synonym: "increased periosteal diameter of fibula" EXACT []
synonym: "thick fibula" EXACT []
is_a: MP:0002187 ! abnormal fibula morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008160
name: increased diameter of humerus
def: "increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of humerus" EXACT []
synonym: "increased periosteal diameter of humerus" EXACT []
synonym: "thick humerus" EXACT []
is_a: MP:0005296 ! abnormal humerus morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008161
name: increased diameter of radius
def: "increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of radius" EXACT []
synonym: "increased periosteal diameter of radius" EXACT []
synonym: "thick radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008162
name: increased diameter of tibia
def: "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of tibia" EXACT []
synonym: "increased periosteal diameter of tibia" EXACT []
synonym: "thick tibia" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008163
name: increased diameter of ulna
def: "increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased outer diameter of ulna" EXACT []
synonym: "increased periosteal diameter of ulna" EXACT []
synonym: "thick ulna" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology
is_a: MP:0008151 ! increased diameter of long bones

[Term]
id: MP:0008164
name: abnormal B-1a B cell morphology
def: "any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "abnormal B-1a B lymphocyte morphology" EXACT []
synonym: "abnormal B-1a B-cell morphology" EXACT []
synonym: "abnormal B-1a B-lymphocyte morphology" EXACT []
synonym: "abnormal B1a cell" EXACT []
is_a: MP:0004940 ! abnormal B-1 B cell morphology

[Term]
id: MP:0008165
name: abnormal B-1b B cell morphology
def: "any structural anomaly of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "abnormal B-1b B lymphocyte morphology" EXACT []
synonym: "abnormal B-1b B-cell morphology" EXACT []
synonym: "abnormal B-1b B-lymphocyte morphology" EXACT []
synonym: "abnormal B1b cell" EXACT []
is_a: MP:0004940 ! abnormal B-1 B cell morphology

[Term]
id: MP:0008166
name: abnormal B-2 B cell morphology
def: "any structural anomaly of a conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "abnormal B-2 B lymphocyte morphology" EXACT []
synonym: "abnormal B-2 B-cell morphology" EXACT []
synonym: "abnormal B-2 B-lymphocyte morphology" EXACT []
synonym: "abnormal B2 cell morphology" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0008167
name: increased B-1a cell number
def: "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
synonym: "increased number of B-1a cells" EXACT []
is_a: MP:0004977 ! increased B-1 B cell number
is_a: MP:0008164 ! abnormal B-1a B cell morphology

[Term]
id: MP:0008168
name: decreased B-1a cell number
def: "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
synonym: "decreased number of B-1a cells" EXACT []
synonym: "reduced B-1a cell number" EXACT []
is_a: MP:0004978 ! decreased B-1 B cell number
is_a: MP:0008164 ! abnormal B-1a B cell morphology

[Term]
id: MP:0008169
name: increased B-1b cell number
def: "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
synonym: "increased number of B-1b cells" EXACT []
is_a: MP:0004977 ! increased B-1 B cell number
is_a: MP:0008165 ! abnormal B-1b B cell morphology

[Term]
id: MP:0008170
name: decreased B-1b cell number
def: "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
synonym: "decreased number of B-1b cells" EXACT []
synonym: "reduced B-1b cell number" EXACT []
is_a: MP:0004978 ! decreased B-1 B cell number
is_a: MP:0008165 ! abnormal B-1b B cell morphology

[Term]
id: MP:0008171
name: abnormal mature B cell morphology
def: "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal mature B lymphocyte morphology" EXACT []
synonym: "abnormal mature B-cell morphology" EXACT []
synonym: "abnormal mature B-lymphocyte morphology" EXACT []
is_a: MP:0004939 ! abnormal B cell morphology
is_a: MP:0008195 ! abnormal professional antigen presenting cell morphology

[Term]
id: MP:0008172
name: abnormal follicular B cell morphology
def: "any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal FOB cell" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0008173
name: increased follicular B cell number
def: "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008172 ! abnormal follicular B cell morphology
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0008174
name: decreased follicular B cell number
def: "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "reduced follicular B cell number" EXACT []
is_a: MP:0008172 ! abnormal follicular B cell morphology
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008175
name: absent follicular B cells
def: "absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "absent FOB cell" EXACT []
is_a: MP:0008174 ! decreased follicular B cell number

[Term]
id: MP:0008176
name: abnormal germinal center B cell morphology
def: "any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal germinal centre B cell morphology" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0008177
name: increased germinal center B cell number
def: "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
synonym: "increased germinal centre B cell number" EXACT []
is_a: MP:0008210 ! increased mature B cell number
is_a: MP:0013680 ! abnormal germinal center B cell number

[Term]
id: MP:0008178
name: decreased germinal center B cell number
def: "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
subset: Sanger_Terms
synonym: "decreased germinal centre B cell number" EXACT []
synonym: "reduced germinal center B cell number" EXACT []
synonym: "reduced germinal centre B cell number" EXACT []
is_a: MP:0008211 ! decreased mature B cell number
is_a: MP:0013680 ! abnormal germinal center B cell number

[Term]
id: MP:0008179
name: absent germinal center B cells
def: "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
synonym: "absent germinal centre B cells" EXACT []
is_a: MP:0008178 ! decreased germinal center B cell number

[Term]
id: MP:0008180
name: abnormal marginal zone B cell morphology
def: "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal MZB cell" EXACT []
is_a: MP:0002362 ! abnormal spleen marginal zone morphology
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0008181
name: increased marginal zone B cell number
def: "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
is_a: MP:0008180 ! abnormal marginal zone B cell morphology
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0008182
name: decreased marginal zone B cell number
def: "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
synonym: "reduced marginal zone B cell number" EXACT []
is_a: MP:0008180 ! abnormal marginal zone B cell morphology
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008183
name: absent marginal zone B cells
def: "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
synonym: "absent MZB cell" EXACT []
is_a: MP:0008182 ! decreased marginal zone B cell number

[Term]
id: MP:0008184
name: abnormal naive B cell morphology
def: "any structural anomaly of a mature B cell which has not yet been activated by antigen" [CL:0000788, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal naive B lymphocyte morphology" EXACT []
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0008185
name: decreased naive B cell number
def: "reduced number of mature B cells which have not yet been activated by antigen" [CL:0000788, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased number of naive B cells" EXACT []
synonym: "reduced naive B cell number" EXACT []
is_a: MP:0008184 ! abnormal naive B cell morphology

[Term]
id: MP:0008186
name: increased pro-B cell number
def: "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "increased number of pro-B cells" EXACT []
is_a: MP:0005432 ! abnormal pro-B cell morphology

[Term]
id: MP:0008187
name: absent pro-B cells
def: "absence of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008208 ! decreased pro-B cell number

[Term]
id: MP:0008188
name: abnormal transitional stage B cell morphology
def: "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal transitional B cell" EXACT []
synonym: "abnormal transitional stage B lymphocyte" EXACT []
synonym: "abnormal transitional stage B-cell" EXACT []
is_a: MP:0005022 ! abnormal immature B cell morphology

[Term]
id: MP:0008189
name: increased transitional stage B cell number
def: "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "increased transitional B cell number" EXACT []
synonym: "increased transitional stage B lymphocyte number" EXACT []
synonym: "increased transitional stage B-cell number" EXACT []
is_a: MP:0008188 ! abnormal transitional stage B cell morphology
is_a: MP:0008214 ! increased immature B cell number

[Term]
id: MP:0008190
name: decreased transitional stage B cell number
def: "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "decreased transitional B cell number" EXACT []
synonym: "decreased transitional stage B lymphocyte number" EXACT []
synonym: "decreased transitional stage B-cell number" EXACT []
is_a: MP:0008188 ! abnormal transitional stage B cell morphology
is_a: MP:0008215 ! decreased immature B cell number

[Term]
id: MP:0008191
name: abnormal follicular B cell physiology
def: "abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen" [CL:0000843, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008192
name: abnormal germinal center B cell physiology
def: "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
synonym: "abnormal germinal centre B cell physiology" EXACT []
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008193
name: abnormal marginal zone B cell physiology
def: "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008194
name: abnormal memory B cell physiology
def: "abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008195
name: abnormal professional antigen presenting cell morphology
def: "any structural anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response" [CL:0000145, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "abnormal antigen presenting cell morphology" RELATED []
is_a: MP:0000716 ! abnormal immune system cell morphology

[Term]
id: MP:0008196
name: abnormal follicular dendritic cell morphology
def: "any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, https://orcid.org/0000-0003-3691-0324, MESH:A10.549.250.200]
comment: Follicular dendritic cells are a distinct population from other dendritic cells associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. They are not derived from the hematopoietic lineage. Due to its unique lineage and distinct function (B cell vs. T cell presentation), this is NOT a type of dendritic cell.
is_a: MP:0000716 ! abnormal immune system cell morphology

[Term]
id: MP:0008197
name: abnormal follicular dendritic cell physiology
def: "abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, https://orcid.org/0000-0003-3691-0324, MESH:A10.549.250.200]
comment: Annotations to this cell type have been erroneously made to dendritic cell morphology. These are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. They are not derived from the hematopoietic lineage. Due to its unique lineage and distinct function (B cell vs. T cell presentation), this is NOT a type of dendritic cell.
is_a: MP:0001819 ! abnormal immune cell physiology

[Term]
id: MP:0008198
name: abnormal follicular dendritic cell antigen presentation
def: "anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001835 ! abnormal antigen presentation
is_a: MP:0008197 ! abnormal follicular dendritic cell physiology

[Term]
id: MP:0008199
name: increased follicular dendritic cell number
def: "greater number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
synonym: "increased number of follicular dendritic cells" EXACT []
is_a: MP:0008196 ! abnormal follicular dendritic cell morphology

[Term]
id: MP:0008200
name: decreased follicular dendritic cell number
def: "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
synonym: "decreased number of follicular dendritic cells" EXACT []
synonym: "reduced follicular dendritic cell number" EXACT []
is_a: MP:0008196 ! abnormal follicular dendritic cell morphology

[Term]
id: MP:0008201
name: absent follicular dendritic cells
def: "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, https://orcid.org/0000-0003-3691-0324, MESH:A10.549.250.200]
is_a: MP:0008200 ! decreased follicular dendritic cell number

[Term]
id: MP:0008202
name: absent B-1 B cells
def: "absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
is_a: MP:0004978 ! decreased B-1 B cell number

[Term]
id: MP:0008203
name: absent B-1a cells
def: "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
is_a: MP:0008168 ! decreased B-1a cell number
is_a: MP:0008202 ! absent B-1 B cells

[Term]
id: MP:0008204
name: absent B-1b cells
def: "absence of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
is_a: MP:0008170 ! decreased B-1b cell number
is_a: MP:0008202 ! absent B-1 B cells

[Term]
id: MP:0008205
name: absent B-2 B cells
def: "absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "absent B-2 B lymphocytes" EXACT []
synonym: "absent B-2 B-cells" EXACT []
synonym: "absent B-2 B-lymphocytes" EXACT []
synonym: "absent B2 cells" EXACT []
is_a: MP:0008207 ! decreased B-2 B cell number

[Term]
id: MP:0008206
name: increased B-2 B cell number
def: "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "increased number of B-2 cells" EXACT []
is_a: MP:0008166 ! abnormal B-2 B cell morphology
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0008207
name: decreased B-2 B cell number
def: "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, https://orcid.org/0000-0003-3691-0324, PMID:11861604]
synonym: "decreased number of B-2 cells" EXACT []
synonym: "reduced B-2 cell number" EXACT []
is_a: MP:0008166 ! abnormal B-2 B cell morphology
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008208
name: decreased pro-B cell number
def: "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "decreased number of pro-B cells" EXACT []
synonym: "decreased pro-B lymphocyte cell number" EXACT []
synonym: "reduced pro-B cell number" EXACT []
is_a: MP:0005432 ! abnormal pro-B cell morphology

[Term]
id: MP:0008209
name: decreased pre-B cell number
def: "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "decreased number of pre-B cells" EXACT []
synonym: "decreased pre-B lymphocyte cell number" EXACT []
synonym: "reduced pre-B cell number" EXACT []
is_a: MP:0002403 ! abnormal pre-B cell morphology
is_a: MP:0005017 ! decreased B cell number

[Term]
id: MP:0008210
name: increased mature B cell number
def: "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased number of mature B cells" EXACT []
synonym: "increased number of mature B lymphocytes" EXACT []
synonym: "increased number of mature B-cells" EXACT []
synonym: "increased number of mature B-lymphocytes" EXACT []
is_a: MP:0005014 ! increased B cell number
is_a: MP:0013701 ! abnormal mature B cell number

[Term]
id: MP:0008211
name: decreased mature B cell number
def: "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased number of mature B cells" EXACT []
synonym: "decreased number of mature B lymphocytes" EXACT []
synonym: "decreased number of mature B-cells" EXACT []
synonym: "decreased number of mature B-lymphocytes" EXACT []
synonym: "reduced mature B cell number" EXACT []
is_a: MP:0005017 ! decreased B cell number
is_a: MP:0013701 ! abnormal mature B cell number

[Term]
id: MP:0008212
name: absent mature B cells
def: "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
synonym: "absent mature B lymphocyte" EXACT []
synonym: "absent mature B-cell" EXACT []
synonym: "absent mature B-lymphocyte" EXACT []
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008213
name: absent immature B cells
def: "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "absent immature B lymphocyte" EXACT []
synonym: "absent immature B-cell" EXACT []
synonym: "absent immature B-lymphocyte" EXACT []
is_a: MP:0008215 ! decreased immature B cell number

[Term]
id: MP:0008214
name: increased immature B cell number
def: "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "increased number of immature B cells" EXACT []
synonym: "increased number of immature B lymphocytes" EXACT []
synonym: "increased number of immature B-cells" EXACT []
synonym: "increased number of immature B-lymphocytes" EXACT []
is_a: MP:0005014 ! increased B cell number
is_a: MP:0013664 ! abnormal immature B cell number

[Term]
id: MP:0008215
name: decreased immature B cell number
def: "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7, MGI:cwg]
synonym: "decreased number of immature B cells" EXACT []
synonym: "decreased number of immature B lymphocytes" EXACT []
synonym: "decreased number of immature B-cells" EXACT []
synonym: "decreased number of immature B-lymphocytes" EXACT []
synonym: "reduced immature B cell number" EXACT []
is_a: MP:0005017 ! decreased B cell number
is_a: MP:0013664 ! abnormal immature B cell number

[Term]
id: MP:0008216
name: absent transitional stage B cells
def: "absence of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149]
synonym: "absent T1 B cell" NARROW []
synonym: "absent T2 B cell" NARROW []
synonym: "absent T3 B cell" NARROW []
synonym: "absent transitional stage B lymphocyte" EXACT []
synonym: "absent transitional stage B-cell" EXACT []
synonym: "absent transitional stage B-lymphocyte" EXACT []
is_a: MP:0008190 ! decreased transitional stage B cell number

[Term]
id: MP:0008217
name: abnormal B cell activation
def: "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008218
name: delayed emergence of vibrissae
def: "eruption of the vibrissae from the skin later than expected" [MGI:brs]
comment: In mouse, the vibrissae emerge at approximately embryonic day E17-18.
synonym: "delayed emergence of sinus hairs" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology
is_a: MP:0020982 ! abnormal skin adnexa development

[Term]
id: MP:0008219
name: abnormal dorsal telencephalic commissure morphology
def: "any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082]
synonym: "abnormal dorsal commissure" EXACT []
is_a: MP:0002199 ! abnormal brain commissure morphology

[Term]
id: MP:0008220
name: abnormal ventral commissure morphology
def: "any structural anomaly of the fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures" [PMID:16715082]
is_a: MP:0002199 ! abnormal brain commissure morphology

[Term]
id: MP:0008221
name: abnormal hippocampal commissure morphology
def: "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8]
synonym: "abnormal commissure fornicis" EXACT []
synonym: "abnormal commissure hippocampi" EXACT []
synonym: "abnormal commissure of fornix" EXACT []
synonym: "abnormal delta fornicis" EXACT []
synonym: "abnormal hippocampus commissure" EXACT []
synonym: "abnormal ventral hippocampal commissure" NARROW []
synonym: "abnormal vhc" NARROW []
is_a: MP:0008219 ! abnormal dorsal telencephalic commissure morphology

[Term]
id: MP:0008222
name: decreased hippocampal commissure size
def: "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8]
synonym: "decreased size of hippocampal commissure" EXACT []
synonym: "reduced size of commissure fornicis" EXACT []
synonym: "reduced size of commissure hippocampi" EXACT []
synonym: "reduced size of commissure of fornix" EXACT []
synonym: "reduced size of delta fornicis" EXACT []
synonym: "reduced size of hippocampus commissure" EXACT []
synonym: "reduced size of ventral hippocampal commissure" NARROW []
synonym: "reduced size of vhc" NARROW []
is_a: MP:0008221 ! abnormal hippocampal commissure morphology

[Term]
id: MP:0008223
name: absent hippocampal commissure
def: "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8]
synonym: "absent commissure fornicis" EXACT []
synonym: "absent commissure hippocampi" EXACT []
synonym: "absent commissure of fornix" EXACT []
synonym: "absent delta fornicis" EXACT []
synonym: "absent hippocampus commissure" EXACT []
synonym: "absent ventral hippocampal commissure" NARROW []
synonym: "absent vhc" NARROW []
is_a: MP:0008221 ! abnormal hippocampal commissure morphology

[Term]
id: MP:0008224
name: increased hippocampal commissure size
def: "enlarged triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8]
synonym: "enlarged hippocampal commissure" EXACT []
synonym: "increased size of commissure fornicis" EXACT []
synonym: "increased size of commissure hippocampi" EXACT []
synonym: "increased size of commissure of fornix" EXACT []
synonym: "increased size of delta fornicis" EXACT []
synonym: "increased size of hippocampal commissure" EXACT []
synonym: "increased size of hippocampus commissure" EXACT []
synonym: "increased size of ventral hippocampal commissure" NARROW []
synonym: "increased size of vhc" NARROW []
is_a: MP:0008221 ! abnormal hippocampal commissure morphology

[Term]
id: MP:0008225
name: abnormal anterior commissure morphology
def: "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8]
synonym: "abnormal Ac" EXACT []
synonym: "abnormal commissura anterior" EXACT []
synonym: "abnormal commissure anterior" EXACT []
is_a: MP:0008220 ! abnormal ventral commissure morphology

[Term]
id: MP:0008226
name: decreased anterior commissure size
def: "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8]
synonym: "decreased size of anterior commissure" EXACT []
synonym: "reduced size of Ac" EXACT []
synonym: "reduced size of anterior commissure" EXACT []
synonym: "reduced size of commissura anterior" EXACT []
synonym: "reduced size of commissure anterior" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology

[Term]
id: MP:0008227
name: absent anterior commissure
def: "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8]
synonym: "absent Ac" EXACT []
synonym: "absent commissura anterior" EXACT []
synonym: "absent commissure anterior" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology

[Term]
id: MP:0008228
name: increased anterior commissure size
def: "enlarged round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8]
synonym: "enlarged anterior commissure" EXACT []
synonym: "increased size of Ac" EXACT []
synonym: "increased size of anterior commissure" EXACT []
synonym: "increased size of commissura anterior" EXACT []
synonym: "increased size of commissure anterior" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology

[Term]
id: MP:0008229
name: obsolete abnormal pars posterior morphology
def: "OBSOLETE. any structural anomaly of the horseshoe-shaped tract that connects the two olfactory bulbs" [PMID:8689685]
is_obsolete: true
consider: MP:0010860

[Term]
id: MP:0008230
name: obsolete abnormal pars anterior morphology
def: "OBSOLETE. any structural anomaly of the major forebrain commissure that connects the two temporal lobes of the cortex" [https://orcid.org/0000-0003-3691-0324, PMID:8689685]
is_obsolete: true
consider: MP:0010859

[Term]
id: MP:0008231
name: abnormal habenular commissure morphology
def: "any structural anomaly of the connection between the right and left habenular nuclei; the decussation of fibers of the two striae medullares, forming the dorsal portion of the peduncle of the pineal body" [ISBN:0-683-40008-8]
synonym: "abnormal commissure habenularum" EXACT []
is_a: MP:0008220 ! abnormal ventral commissure morphology

[Term]
id: MP:0008232
name: abnormal cingulum morphology
def: "any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000778 ! abnormal nervous system tract morphology
is_a: MP:0008026 ! abnormal brain white matter morphology

[Term]
id: MP:0008233
name: abnormal pro-B cell differentiation
def: "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0005432 ! abnormal pro-B cell morphology

[Term]
id: MP:0008234
name: absent spleen marginal zone
def: "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8]
synonym: "absent splenic marginal zone" EXACT []
is_a: MP:0002362 ! abnormal spleen marginal zone morphology

[Term]
id: MP:0008235
name: increased susceptibility to neuronal excitotoxicity
def: "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to neuronal excitotoxicity" EXACT []
synonym: "increased susceptibility to neurotoxicity-induced cell death" EXACT []
is_a: MP:0003203 ! increased neuron apoptosis
is_a: MP:0008873 ! increased physiological sensitivity to xenobiotic

[Term]
id: MP:0008236
name: decreased susceptibility to neuronal excitotoxicity
def: "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to neurotoxicity-induced cell death" EXACT []
synonym: "increased resistance to neuronal excitotoxicity" EXACT []
synonym: "reduced susceptibility to neuronal excitotoxicity" EXACT []
is_a: MP:0003204 ! decreased neuron apoptosis
is_a: MP:0008874 ! decreased physiological sensitivity to xenobiotic

[Term]
id: MP:0008237
name: abnormal ventral coat pigmentation
def: "irregular or unusual pigmentation of ventrum hair in relation to control animals" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0008238
name: abnormal dorsoventral coat patterning
def: "irregular or unusual pigmentation pattern of the dorsal-to-ventral axis compared to control animals" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0008239
name: obsolete epigenetic coat coloration
def: "OBSOLETE. a range of wild-type and mutant allele coat coloration, from mouse to mouse or coat color mosaicism of an individual mouse, due to differential methylation of the mutation causing element" [MGI:llw2]
is_obsolete: true

[Term]
id: MP:0008240
name: abnormal spleen marginal zone macrophage morphology
def: "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
comment: Spleen marginal zone macrophage cells express the cell surface protein CD209b (also called Signr1), which is often detected with the ER-TR9 antibody.
synonym: "abnormal ER-TR9 positive cells" EXACT []
synonym: "abnormal splenic marginal zone macrophage morphology" EXACT []
is_a: MP:0002362 ! abnormal spleen marginal zone morphology
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0008241
name: abnormal metallophilic macrophage morphology
def: "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
comment: Metallophilic macrophage cells express the cell surface protein Siglec1 (also called CD169 or sialoadhesin), which is often detected with the MOMA-1 antibody.
synonym: "abnormal marginal metallophilic macrophage" EXACT []
synonym: "abnormal MOMA-1 positive cells" EXACT []
synonym: "abnormal splenic marginal metallophilic macrophages" EXACT []
synonym: "abnormal splenic metallophilic macrophage morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0008242
name: abnormal perivascular macrophage morphology
def: "any structural anomaly of macrophages that line the small blood vessels" [PMID:16322748]
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0008243
name: abnormal macrophage derived foam cell morphology
def: "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
xref: CL:0000517
is_a: MP:0002446 ! abnormal macrophage morphology
is_a: MP:0009840 ! abnormal foam cell morphology

[Term]
id: MP:0008244
name: abnormal peritoneal macrophage morphology
def: "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
synonym: "abnormal PCM morphology" EXACT []
synonym: "abnormal peritoneal cavity macrophage morphology" EXACT []
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0008245
name: abnormal alveolar macrophage morphology
def: "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
is_a: MP:0002446 ! abnormal macrophage morphology
is_a: MP:0010901 ! abnormal pulmonary alveolar parenchyma morphology

[Term]
id: MP:0008246
name: abnormal leukocyte morphology
def: "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
synonym: "abnormal leucocyte morphology" EXACT []
synonym: "abnormal WBC morphology" EXACT []
synonym: "leucocyte abnormalities" BROAD []
synonym: "leukocyte abnormalities" BROAD []
synonym: "white blood cell abnormalities" BROAD []
is_a: MP:0000716 ! abnormal immune system cell morphology
is_a: MP:0013656 ! abnormal hematopoietic cell morphology

[Term]
id: MP:0008247
name: abnormal mononuclear cell morphology
def: "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
synonym: "abnormal mononuclear leucocyte morphology" EXACT []
synonym: "abnormal mononuclear leukocyte morphology" EXACT []
is_a: MP:0008246 ! abnormal leukocyte morphology

[Term]
id: MP:0008248
name: abnormal mononuclear phagocyte morphology
def: "any structural anomaly of a vertebrate phagocyte with a single nucleus" [CL:0000113]
is_a: MP:0008247 ! abnormal mononuclear cell morphology
is_a: MP:0008251 ! abnormal phagocyte morphology

[Term]
id: MP:0008249
name: abnormal common lymphocyte progenitor cell morphology
def: "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
synonym: "abnormal CLP" EXACT []
synonym: "abnormal common lymphoid progenitor cell" EXACT []
synonym: "lymphoid stem cell abnormalities" EXACT []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0008250
name: abnormal myeloid leukocyte morphology
def: "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
synonym: "abnormal myeloid leucocyte morphology" EXACT []
is_a: MP:0008246 ! abnormal leukocyte morphology
is_a: MP:0013658 ! abnormal myeloid cell morphology

[Term]
id: MP:0008251
name: abnormal phagocyte morphology
def: "any structural anomaly of cells capable of ingesting particulate matter via phagocytosis" [CL:0000234, ISBN:0721601464]
synonym: "abnormal phagocytic cell morphology" EXACT []
is_a: MP:0008250 ! abnormal myeloid leukocyte morphology

[Term]
id: MP:0008252
name: abnormal multinucleated phagocyte morphology
def: "any structural anomaly of a phagocyte formed by the fusion of mononuclear phagocytes" [CL:0000783]
is_a: MP:0008251 ! abnormal phagocyte morphology

[Term]
id: MP:0008253
name: absent megakaryocytes
def: "absence of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm" [CL:0000556, ISBN:0721601464]
synonym: "absent megacaryocytes" EXACT []
synonym: "absent megalocaryocytes" EXACT []
synonym: "absent megalokaryocytes" EXACT []
is_a: MP:0008255 ! decreased megakaryocyte cell number

[Term]
id: MP:0008254
name: increased megakaryocyte cell number
def: "greater number of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm" [CL:0000556, ISBN:0721601464]
synonym: "increased megacaryocyte cell number" EXACT []
synonym: "increased megalocaryocyte cell number" EXACT []
synonym: "increased megalokaryocyte cell number" EXACT []
synonym: "increased number of megakaryocytes" EXACT []
is_a: MP:0002417 ! abnormal megakaryocyte morphology

[Term]
id: MP:0008255
name: decreased megakaryocyte cell number
def: "reduced number of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm" [CL:0000556, ISBN:0721601464]
synonym: "decreased megacaryocyte cell number" EXACT []
synonym: "decreased megalocaryocyte cell number" EXACT []
synonym: "decreased megalokaryocyte cell number" EXACT []
synonym: "decreased number of megakaryocytes" EXACT []
synonym: "reduced megakaryocyte cell number" EXACT []
synonym: "reduced number of megakaryocytes" EXACT []
is_a: MP:0002417 ! abnormal megakaryocyte morphology

[Term]
id: MP:0008256
name: abnormal myometrium morphology
def: "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs]
synonym: "abnormal uterine smooth muscle morphology" EXACT []
synonym: "abnormal uterus smooth muscle morphology" RELATED []
synonym: "myometrium dysplasia" NARROW []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0008257
name: thin myometrium
def: "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs]
synonym: "thin uterine smooth muscle" EXACT []
synonym: "thin uterus smooth muscle" EXACT []
is_a: MP:0008256 ! abnormal myometrium morphology

[Term]
id: MP:0008258
name: thin endometrium
def: "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [https://orcid.org/0000-0003-4606-0597, MESH:A05.360.319.679.490]
is_a: MP:0004896 ! abnormal endometrium morphology

[Term]
id: MP:0008259
name: abnormal optic disk morphology
alt_id: MP:0002793
alt_id: MP:0006215
def: "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal optic disc" BROAD []
synonym: "abnormal optic disc morphology" EXACT []
synonym: "abnormal optic disk" BROAD []
synonym: "abnormal optic nerve head morphology" RELATED []
synonym: "optic disc abnormalities" BROAD []
synonym: "optic disc dysplasia" NARROW []
synonym: "optic disk abnormalities" BROAD []
synonym: "optic disk dysplasia" NARROW []
is_a: MP:0001330 ! abnormal optic nerve morphology
is_a: MP:0002864 ! abnormal ocular fundus morphology

[Term]
id: MP:0008260
name: abnormal autophagy
def: "abnormal catabolic process involving the degradation of a cell's own components through the lysosomal machinery" [https://orcid.org/0000-0001-7973-5445]
synonym: "abnormal autophagocytosis" EXACT []
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0008261
name: arrest of male meiosis
def: "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8]
is_a: MP:0001155 ! arrest of spermatogenesis
is_a: MP:0005169 ! abnormal male meiosis

[Term]
id: MP:0008262
name: abnormal hippocampus region morphology
def: "any structural anomaly of a part or parts of the hippocampus that have a particular function" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hippocampal area" BROAD []
synonym: "abnormal hippocampal region morphology" EXACT []
synonym: "abnormal hippocampal subfield morphology" BROAD []
synonym: "abnormal hippocampus area" BROAD []
synonym: "abnormal hippocampus subfield morphology" RELATED []
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0008263
name: abnormal hippocampus CA1 region morphology
def: "any structural anomaly of a cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation consisting primarily of pyramidal neurons; the pyramidal neurons of CA1 receive projections from pyramidal neurons of CA3 via the Schaffer collaterals and send outputs to the entorhinal cortex and to the subiculum" [NLX:birnlex_1197]
synonym: "abnormal CA1 field morphology" EXACT []
synonym: "abnormal CA1 field of Ammon's horn" EXACT []
synonym: "abnormal Cornu Ammonis 1" EXACT []
synonym: "abnormal field CA1 of hippocampus" EXACT []
synonym: "abnormal regio superior of the hippocampus" EXACT []
synonym: "abnormal region I of hippocampus proper" EXACT []
is_a: MP:0000815 ! abnormal Ammon gyrus morphology
is_a: MP:0008262 ! abnormal hippocampus region morphology

[Term]
id: MP:0008264
name: absent hippocampus CA1 region
def: "missing the CA1 region of the hippocampus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent CA1 field morphology" EXACT []
synonym: "absent CA1 field of Ammon's horn" EXACT []
synonym: "absent Cornu Ammonis 1" EXACT []
synonym: "absent field CA1 of hippocampus" EXACT []
synonym: "absent regio superior of the hippocampus" EXACT []
is_a: MP:0008263 ! abnormal hippocampus CA1 region morphology

[Term]
id: MP:0008265
name: abnormal hippocampus CA2 region morphology
def: "any structural anomaly of the smallest cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation, located between CA3 and CA1, comprised of pyramidal neurons receiving both Schaffer collateral and mossy fiber input" [NLX:birnlex_1362]
synonym: "abnormal CA2 field morphology" EXACT []
synonym: "abnormal CA2 field of Ammon's horn" EXACT []
synonym: "abnormal Cornu Ammonis 2" EXACT []
synonym: "abnormal field CA2 of hippocampus" EXACT []
synonym: "abnormal region II of hippocampus proper" EXACT []
is_a: MP:0000815 ! abnormal Ammon gyrus morphology
is_a: MP:0008262 ! abnormal hippocampus region morphology

[Term]
id: MP:0008266
name: absent hippocampus CA2 region
def: "missing the CA2 region of the hippocampus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent CA2 field morphology" EXACT []
synonym: "absent CA2 field of Ammon's horn" EXACT []
synonym: "absent Cornu Ammonis 2" EXACT []
synonym: "absent field CA2 of hippocampus" EXACT []
is_a: MP:0008265 ! abnormal hippocampus CA2 region morphology

[Term]
id: MP:0008267
name: abnormal hippocampus CA3 region morphology
def: "any structural anomaly in the region of the hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers" [http://purl.obolibrary.org/obo/UBERON_0003883]
synonym: "abnormal CA3 field morphology" EXACT []
synonym: "abnormal CA3 field of Ammon's horn" EXACT []
synonym: "abnormal Cornu Ammonis 3" EXACT []
synonym: "abnormal field CA3 of hippocampus" EXACT []
is_a: MP:0000815 ! abnormal Ammon gyrus morphology
is_a: MP:0008262 ! abnormal hippocampus region morphology

[Term]
id: MP:0008268
name: absent hippocampus CA3 region
def: "missing the CA3 region of the hippocampus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent CA3 field morphology" EXACT []
synonym: "absent CA3 field of Ammon's horn" EXACT []
synonym: "absent Cornu Ammonis 3" EXACT []
synonym: "absent field CA3 of hippocampus" EXACT []
is_a: MP:0008267 ! abnormal hippocampus CA3 region morphology

[Term]
id: MP:0008269
name: abnormal hippocampus CA4 region morphology
def: "any structural anomaly of the region of the hippocampal formation that is comprised of mossy cells that primarily receive inputs from granule cells in the dentate gyrus in the form of mossy fibers and from pyramidal cells in CA3, and send outputs into the dentate gyrus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal dentate gyrus hilus morphology" EXACT []
synonym: "abnormal field CA4 of hippocampal formation" EXACT []
synonym: "abnormal hilus of dentate gyrus morphology" EXACT []
is_a: MP:0000812 ! abnormal dentate gyrus morphology
is_a: MP:0008262 ! abnormal hippocampus region morphology

[Term]
id: MP:0008270
name: absent hippocampus CA4 region
def: "missing the CA4 region of the hippocampus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent dentate gyrus hilus" EXACT []
synonym: "absent field CA4 of hippocampal formation" EXACT []
synonym: "absent hilus of dentate gyrus" EXACT []
is_a: MP:0008269 ! abnormal hippocampus CA4 region morphology

[Term]
id: MP:0008271
name: abnormal bone ossification
alt_id: MP:0000057
alt_id: MP:0001535
alt_id: MP:0001536
def: "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
synonym: "abnormal bone biosynthesis" EXACT []
synonym: "abnormal bone formation" EXACT []
synonym: "abnormal osteogenesis" EXACT []
synonym: "osteogenesis abnormalities" EXACT []
is_a: MP:0001533 ! abnormal skeleton physiology

[Term]
id: MP:0008272
name: abnormal endochondral bone ossification
def: "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0008273
name: abnormal intramembranous bone ossification
def: "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0008274
name: failure of bone ossification
def: "failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
synonym: "failure of bone biosynthesis" EXACT []
synonym: "failure of bone formation" EXACT []
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0008275
name: failure of endochondral bone ossification
def: "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
is_a: MP:0008272 ! abnormal endochondral bone ossification
is_a: MP:0008274 ! failure of bone ossification

[Term]
id: MP:0008276
name: failure of intramembranous bone ossification
def: "failure to initiate or a block in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
is_a: MP:0008273 ! abnormal intramembranous bone ossification
is_a: MP:0008274 ! failure of bone ossification

[Term]
id: MP:0008277
name: abnormal sternum ossification
def: "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, https://orcid.org/0009-0005-7755-8314]
is_a: MP:0008272 ! abnormal endochondral bone ossification

[Term]
id: MP:0008278
name: failure of sternum ossification
def: "failure to initiate or a block in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, https://orcid.org/0009-0005-7755-8314]
is_a: MP:0008275 ! failure of endochondral bone ossification
is_a: MP:0008277 ! abnormal sternum ossification

[Term]
id: MP:0008279
name: arrest of spermiogenesis
def: "block in the process by which a spermatid transforms into a functional spermatozoon" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "arrest of spermatid cell development" EXACT []
synonym: "arrest of spermatid development" EXACT []
is_a: MP:0001155 ! arrest of spermatogenesis
is_a: MP:0001932 ! abnormal spermiogenesis

[Term]
id: MP:0008280
name: abnormal male germ cell apoptosis
def: "change in the timing or the number of male germ cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0020362 ! abnormal male germ cell physiology

[Term]
id: MP:0008281
name: abnormal hippocampus size
def: "anomaly in the size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0008282
name: enlarged hippocampus
def: "increased size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
subset: IMPC
subset: Sanger_Terms
synonym: "increased hippocampus size" EXACT []
is_a: MP:0008281 ! abnormal hippocampus size

[Term]
id: MP:0008283
name: small hippocampus
def: "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-12-402035-6]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased hippocampus size" EXACT []
is_a: MP:0008281 ! abnormal hippocampus size

[Term]
id: MP:0008284
name: abnormal hippocampus pyramidal cell layer
def: "any structural anomaly of the cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3" [ISSN:0073-0114, UBERON_0002313]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal stratum pyramidale morphology" EXACT []
is_a: MP:0000813 ! abnormal hippocampus layer morphology

[Term]
id: MP:0008285
name: abnormal hippocampus granule cell layer
def: "any structural anomaly in the layer of the hippocampus composed primarily of granule cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal stratum granulare morphology" EXACT []
is_a: MP:0000813 ! abnormal hippocampus layer morphology

[Term]
id: MP:0008286
name: abnormal hippocampus molecular cell layer
def: "any structural anomaly of the cytoarchitectural region of the hippocampus consisting of a composite of the two outermost layers of the hippocampus, the Stratum lacunosum-moleculare and the Stratum radiatum" [ISBN:9780683014617, UBERON_0005368]
synonym: "abnormal stratum moleculare morphology" EXACT []
is_a: MP:0000813 ! abnormal hippocampus layer morphology

[Term]
id: MP:0008287
name: abnormal subiculum morphology
def: "any structural anomaly of the transitional zone between the parahippocampal gyrus and the Ammon gyrus" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0000807 ! abnormal hippocampus morphology

[Term]
id: MP:0008288
name: abnormal adrenal cortex morphology
def: "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "abnormal adrenal capsule cortex" EXACT []
synonym: "abnormal adrenal gland cortex morphology" EXACT []
synonym: "abnormal adrenocortex morphology" EXACT []
synonym: "abnormal suprarenal gland cortex morphology" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0008289
name: abnormal adrenal medulla morphology
def: "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2]
synonym: "abnormal adrenal gland medulla morphology" EXACT []
synonym: "abnormal suprarenal gland medulla morphology" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0008290
name: absent adrenal cortex
def: "absence of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "absent adrenal capsule cortex" EXACT []
synonym: "absent adrenal gland cortex" EXACT []
synonym: "absent suprarenal gland cortex" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008291
name: abnormal adrenocortical cell morphology
def: "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2]
synonym: "abnormal cortical cell morphology" BROAD []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008292
name: enlarged adrenocortical cell nuclei
def: "nuclei of the cells of the cortex of the adrenal gland are larger than normal" [MGI:llw2]
synonym: "adrenocortical cell nuclei hypertrophy" EXACT []
synonym: "increased adrenocortical cell nuclei size" EXACT []
is_a: MP:0000646 ! enlarged adrenocortical cells

[Term]
id: MP:0008293
name: abnormal adrenal gland zona glomerulosa morphology
def: "any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced" [MESH:A06.407.071.140.960, MGI:llw2]
synonym: "abnormal adrenal glomerulosa morphology" EXACT []
synonym: "abnormal zona glomerulosa morphology" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008294
name: abnormal adrenal gland zona fasciculata morphology
def: "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
synonym: "abnormal adrenal fasciculata morphology" EXACT []
synonym: "abnormal zona fasciculata morphology" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008295
name: abnormal adrenal gland zona reticularis morphology
def: "any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]
synonym: "abnormal adrenal reticularis morphology" EXACT []
synonym: "abnormal zona reticularis morphology" EXACT []
synonym: "abnormal zona reticulata morphology" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008296
name: abnormal adrenal gland x-zone morphology
def: "any structural anomaly of the transient cortical layer juxtaposed to the medulla and the zona reticularis; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females" [MGI:llw2, PMID:3582592]
synonym: "abnormal juxtamedullary x-zone morphology" EXACT []
synonym: "abnormal transient zone morphology" EXACT []
synonym: "abnormal x zone morphology" EXACT []
synonym: "abnormal x-zone morphology" EXACT []
xref: MA:0001887
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008297
name: retention of the adrenal gland x-zone
def: "failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females" [MGI:llw2, PMID:3582592]
synonym: "persistent fetal x-zone" EXACT []
synonym: "persistent foetal x-zone" EXACT []
synonym: "retention of the fetal (adrenal gland) x-zone" EXACT []
synonym: "retention of the foetal (adrenal gland) x-zone" EXACT []
synonym: "retention of the x-zone" EXACT []
is_a: MP:0008296 ! abnormal adrenal gland x-zone morphology
is_a: MP:0014355 ! abnormal programmed cell death

[Term]
id: MP:0008298
name: adrenergic chromaffin cell hyperplasia
def: "an increase in the number of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003834 ! abnormal adrenergic chromaffin cell morphology

[Term]
id: MP:0008299
name: adrenal cortical hyperplasia
def: "increase in the number of normal cells in normal arrangement in the adrenal cortex, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic adrenal cortex" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008300
name: enlarged adrenal medulla
def: "increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased adrenal medulla size" EXACT []
is_a: MP:0008289 ! abnormal adrenal medulla morphology

[Term]
id: MP:0008301
name: adrenal medulla hyperplasia
def: "increase in the number of normal cells in normal arrangement in the adrenal medulla, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic adrenal medulla" EXACT []
is_a: MP:0008300 ! enlarged adrenal medulla

[Term]
id: MP:0008302
name: thin adrenal cortex
def: "reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008288 ! abnormal adrenal cortex morphology

[Term]
id: MP:0008303
name: early degeneration of the adrenal gland x-zone
def: "degeneration of the transient cortical layer juxtaposed to the medulla and the zona reticularis prior to the expected time; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females" [PMID:3582592]
synonym: "early degeneration of the x-zone" EXACT []
is_a: MP:0008296 ! abnormal adrenal gland x-zone morphology

[Term]
id: MP:0008304
name: abnormal organ of Corti supporting cell differentiation
def: "atypical production of or inability to produce the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004300 ! abnormal organ of Corti supporting cell morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0008305
name: abnormal organ of Corti supporting cell physiology
def: "any functional anomaly in processes pertinent to the integrated function of the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0008306
name: abnormal organ of Corti supporting cell proliferation
def: "aberrant timing or any anomaly in the ability of supporting cells in the organ of Corti to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0008305 ! abnormal organ of Corti supporting cell physiology

[Term]
id: MP:0008307
name: short scala media
def: "reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [https://orcid.org/0000-0002-6490-7723]
synonym: "short cochlear duct" EXACT []
is_a: MP:0008308 ! small scala media

[Term]
id: MP:0008308
name: small scala media
def: "reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [https://orcid.org/0000-0002-6490-7723]
synonym: "small cochlear duct" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0008309
name: dilated scala media
def: "stretched or widened aperture of the luminal space of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [https://orcid.org/0000-0002-6490-7723]
synonym: "cochlear duct dilation" EXACT []
synonym: "dilated cochlear duct" EXACT []
synonym: "dilated cochlear ducts" EXACT []
synonym: "scala media dilation" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0008310
name: abnormal sympathetic preganglionic fiber morphology
def: "any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a sympathetic ganglion" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal sympathetic preganglionic fibre morphology" EXACT []
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0008311
name: abnormal parasympathetic preganglionic fiber morphology
def: "any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal parasympathetic preganglionic fibre morphology" EXACT []
is_a: MP:0001033 ! abnormal parasympathetic system morphology

[Term]
id: MP:0008312
name: abnormal sympathetic postganglionic fiber morphology
def: "any structural anomaly of any or all of the noradrenergic and some adrenergic axonal fibers projecting from a sympathetic ganglion to an effector organ" [https://orcid.org/0000-0003-3691-0324, MESH:A08.663.542.075.800]
synonym: "abnormal sympathetic postganglionic fibre morphology" EXACT []
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0008313
name: abnormal parasympathetic postganglionic fiber morphology
def: "any structural anomaly of any or all of the cholinergic axonal fibers projecting from a parasympathetic ganglion to an effector organ" [https://orcid.org/0000-0003-3691-0324, MESH:A08.663.542.100.700]
synonym: "abnormal parasympathetic postganglionic fibre morphology" EXACT []
is_a: MP:0001033 ! abnormal parasympathetic system morphology

[Term]
id: MP:0008314
name: abnormal pterygopalatine ganglion morphology
def: "any structural anomaly of the small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands" [ISBN:0-683-40008-8]
synonym: "abnormal Meckel ganglion morphology" EXACT []
synonym: "abnormal nasal ganglion morphology" EXACT []
synonym: "abnormal palatine ganglion morphology" EXACT []
synonym: "abnormal pterygopalatine ganglia morphology" EXACT []
synonym: "abnormal sphenopalatine ganglion morphology" EXACT []
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology

[Term]
id: MP:0008315
name: abnormal otic ganglion morphology
def: "any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland" [ISBN:0-683-40008-8]
synonym: "abnormal Arnold ganglion morphology" EXACT []
synonym: "abnormal auricular ganglion morphology" EXACT []
synonym: "abnormal otic ganglia morphology" EXACT []
synonym: "abnormal otoganglion morphology" EXACT []
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology
is_a: MP:0001096 ! abnormal glossopharyngeal ganglion morphology

[Term]
id: MP:0008316
name: abnormal prevertebral ganglion morphology
def: "any structural anomaly of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia" [ISBN:0-683-40008-8]
synonym: "abnormal prevertebral ganglia morphology" EXACT []
is_a: MP:0001008 ! abnormal sympathetic ganglion morphology

[Term]
id: MP:0008317
name: abnormal paravertebral ganglion morphology
def: "any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia" [ISBN:0-683-40008-8]
synonym: "abnormal chain ganglia" EXACT []
synonym: "abnormal chain ganglion" EXACT []
synonym: "abnormal ganglia of sympathetic trunk" EXACT []
synonym: "abnormal paravertebral ganglia" EXACT []
synonym: "abnormal sympathetic chain ganglia" EXACT []
is_a: MP:0001008 ! abnormal sympathetic ganglion morphology

[Term]
id: MP:0008318
name: abnormal splanchnic nerve morphology
def: "any structural anomaly of the major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord, which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses, and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia" [MESH:A08.800.050.050.800]
synonym: "abnormal abdominopelvic splanchnic nerve morphology" NARROW []
synonym: "abnormal cardiopulmonary splanchnic nerve morphology" NARROW []
synonym: "abnormal pelvic splanchnic nerve morphology" NARROW []
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0008319
name: abnormal sympathetic afferent fiber morphology
def: "any structural anomaly of the fibers that conduct sensory nerve impulses from the viscera through the posterior dorsal roots into the spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "abnormal general visceral afferent fiber morphology" EXACT []
synonym: "abnormal general visceral afferent fibre morphology" EXACT []
synonym: "abnormal GVA morphology" EXACT []
synonym: "abnormal sympathetic afferent fibre morphology" EXACT []
is_a: MP:0001007 ! abnormal sympathetic system morphology

[Term]
id: MP:0008320
name: absent adenohypophysis
def: "absence of the anterior part of the pituitary that secretes a variety of hormones" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent adenophysis" EXACT []
synonym: "absent anterior pituitary lobe" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008321
name: small adenohypophysis
def: "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased adenohypophysis size" EXACT []
synonym: "small adenophysis" EXACT []
synonym: "small anterior pituitary lobe" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008322
name: abnormal somatotroph morphology
def: "any structural anomaly of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
synonym: "abnormal growth hormone secreting cell morphology" RELATED []
synonym: "abnormal somatotrope morphology" EXACT []
synonym: "abnormal somatotrophin secreting cell morphology" EXACT []
synonym: "abnormal somatotropic cell morphology" EXACT []
synonym: "abnormal somatotropin secreting cell morphology" EXACT []
synonym: "abnormal somatrophic cell morphology" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008323
name: abnormal lactotroph morphology
def: "any structural anomaly of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
synonym: "abnormal epsilon-acidophil morphology" EXACT []
synonym: "abnormal lactotrope morphology" EXACT []
synonym: "abnormal lactotropic cell morphology" EXACT []
synonym: "abnormal mammotrope morphology" EXACT []
synonym: "abnormal mammotroph morphology" EXACT []
synonym: "abnormal mammotrophic cell morphology" EXACT []
synonym: "abnormal mammotropic cell morphology" EXACT []
synonym: "abnormal prolactin secreting cell morphology" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008324
name: abnormal melanotroph morphology
def: "any structural anomaly of a cell of the intermediate pituitary that produces melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MESH:A06.407.747.671.500]
synonym: "abnormal melanocyte stimulating hormone secreting cell morphology" EXACT []
synonym: "abnormal melanotrope morphology" EXACT []
is_a: MP:0008130 ! abnormal pituitary intermediate lobe morphology

[Term]
id: MP:0008325
name: abnormal gonadotroph morphology
def: "any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
synonym: "abnormal FSH cells" NARROW []
synonym: "abnormal FSH-producing cells" NARROW []
synonym: "abnormal FSH-secreting cells" NARROW []
synonym: "abnormal gonadotrope morphology" EXACT []
synonym: "abnormal gonadotrophic hormone secreting cell morphology" EXACT []
synonym: "abnormal LH cells" NARROW []
synonym: "abnormal LH-producing cells" NARROW []
synonym: "abnormal LH-secreting cells" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008326
name: abnormal thyrotroph morphology
def: "any structural anomaly of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
synonym: "abnormal pituitary TSH-producing cell" EXACT []
synonym: "abnormal pituitary TSH-secreting cell" EXACT []
synonym: "abnormal thymotrope morphology" EXACT []
synonym: "abnormal thyreotroph morphology" EXACT []
synonym: "abnormal thyroid-hormone secreting cell" RELATED []
synonym: "abnormal thyrotrope morphology" EXACT []
synonym: "abnormal TSH cells" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008327
name: abnormal corticotroph morphology
def: "any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
synonym: "abnormal adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "abnormal adrenocorticotropic hormone secreting cell morphology" EXACT []
synonym: "abnormal corticotrope morphology" EXACT []
synonym: "abnormal corticotrophin hormone secreting cell" EXACT []
synonym: "abnormal corticotropin hormone secreting cell" EXACT []
synonym: "abnormal pituitary ACTH-producing cells" EXACT []
synonym: "abnormal pituitary ACTH-secreting cells" EXACT []
synonym: "abnormal pituitary adrenocorticotropin-secreting cells" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008328
name: increased somatotroph cell number
def: "greater number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
synonym: "increased growth hormone secreting cell number" RELATED []
synonym: "increased somatotrope number" EXACT []
synonym: "increased somatotrophin secreting cell number" EXACT []
synonym: "increased somatotropic cell number" EXACT []
synonym: "increased somatotropin secreting cell number" EXACT []
synonym: "increased somatrophic cell number" EXACT []
synonym: "somatotrope hyperplasia" EXACT []
synonym: "somatotroph cell hyperplasia" EXACT []
synonym: "somatotroph hyperplasia" EXACT []
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008329
name: decreased somatotroph cell number
def: "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
synonym: "decreased growth hormone secreting cell number" RELATED []
synonym: "decreased somatotrope number" EXACT []
synonym: "decreased somatotrophin secreting cell number" EXACT []
synonym: "decreased somatotropic cell number" EXACT []
synonym: "decreased somatotropin secreting cell number" EXACT []
synonym: "decreased somatrophic cell number" EXACT []
synonym: "reduced growth hormone secreting cell number" RELATED []
synonym: "reduced somatotrope number" EXACT []
synonym: "reduced somatotrophin secreting cell number" EXACT []
synonym: "reduced somatotropic cell number" EXACT []
synonym: "reduced somatotropin secreting cell number" EXACT []
synonym: "reduced somatrophic cell number" EXACT []
synonym: "somatotroph cell hypoplasia" EXACT []
synonym: "somatotroph hypoplasia" EXACT []
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008330
name: absent somatotrophs
def: "absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
synonym: "absent growth hormone secreting cell" RELATED []
synonym: "absent somatotrope" EXACT []
synonym: "absent somatotrophin secreting cell" EXACT []
synonym: "absent somatotropic cell" EXACT []
synonym: "absent somatotropin secreting cell" EXACT []
synonym: "absent somatrophic cell" EXACT []
is_a: MP:0008329 ! decreased somatotroph cell number

[Term]
id: MP:0008331
name: increased lactotroph cell number
def: "greater number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
synonym: "increased epsilon-acidophil number" EXACT []
synonym: "increased lactotrope number" EXACT []
synonym: "increased lactotropic cell number" EXACT []
synonym: "increased mammotrope number" EXACT []
synonym: "increased mammotroph number" EXACT []
synonym: "increased mammotrophic cell number" EXACT []
synonym: "increased mammotropic cell number" EXACT []
synonym: "increased prolactin secreting cell number" EXACT []
synonym: "lactotrope hyperplasia" EXACT []
synonym: "lactotroph cell hyperplasia" EXACT []
synonym: "lactotroph hyperplasia" EXACT []
is_a: MP:0008323 ! abnormal lactotroph morphology

[Term]
id: MP:0008332
name: decreased lactotroph cell number
def: "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
synonym: "decreased epsilon-acidophil number" EXACT []
synonym: "decreased lactotrope number" EXACT []
synonym: "decreased lactotropic cell number" EXACT []
synonym: "decreased mammotrope number" EXACT []
synonym: "decreased mammotroph number" EXACT []
synonym: "decreased mammotrophic cell number" EXACT []
synonym: "decreased mammotropic cell number" EXACT []
synonym: "decreased prolactin secreting cell number" EXACT []
synonym: "lactotroph cell hypoplasia" EXACT []
synonym: "lactotroph hypoplasia" EXACT []
synonym: "reduced epsilon-acidophil number" EXACT []
synonym: "reduced lactotrope number" EXACT []
synonym: "reduced lactotropic cell number" EXACT []
synonym: "reduced mammotrope number" EXACT []
synonym: "reduced mammotroph number" EXACT []
synonym: "reduced mammotrophic cell number" EXACT []
synonym: "reduced mammotropic cell number" EXACT []
synonym: "reduced prolactin secreting cell number" EXACT []
is_a: MP:0008323 ! abnormal lactotroph morphology

[Term]
id: MP:0008333
name: absent lactotrophs
def: "absence of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
synonym: "absent epsilon-acidophil" EXACT []
synonym: "absent lactotrope" EXACT []
synonym: "absent lactotropic cell" EXACT []
synonym: "absent mammotrope" EXACT []
synonym: "absent mammotroph" EXACT []
synonym: "absent mammotrophic cell" EXACT []
synonym: "absent mammotropic cell" EXACT []
synonym: "absent prolactin secreting cell" EXACT []
is_a: MP:0008332 ! decreased lactotroph cell number

[Term]
id: MP:0008334
name: increased gonadotroph cell number
def: "greater number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
synonym: "gonadotrope hyperplasia" EXACT []
synonym: "gonadotroph cell hyperplasia" EXACT []
synonym: "gonadotroph hyperplasia" EXACT []
synonym: "increased FSH cell number" NARROW []
synonym: "increased FSH-producing cell number" NARROW []
synonym: "increased FSH-secreting cell number" NARROW []
synonym: "increased gonadotrope number" EXACT []
synonym: "increased gonadotrophic hormone secreting cell number" EXACT []
synonym: "increased LH cell number" NARROW []
synonym: "increased LH-producing cell number" NARROW []
synonym: "increased LH-secreting cell number" EXACT []
is_a: MP:0008325 ! abnormal gonadotroph morphology

[Term]
id: MP:0008335
name: decreased gonadotroph cell number
def: "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
synonym: "decreased FSH cell number" NARROW []
synonym: "decreased FSH-producing cell number" NARROW []
synonym: "decreased FSH-secreting cell number" NARROW []
synonym: "decreased gonadotrope number" EXACT []
synonym: "decreased gonadotrophic hormone secreting cell number" EXACT []
synonym: "decreased LH cell number" NARROW []
synonym: "decreased LH-producing cell number" NARROW []
synonym: "decreased LH-secreting cell number" EXACT []
synonym: "gonadotroph cell hypoplasia" EXACT []
synonym: "gonadotroph hypoplasia" EXACT []
synonym: "reduced FSH cell number" NARROW []
synonym: "reduced FSH-producing cell number" NARROW []
synonym: "reduced FSH-secreting cell number" NARROW []
synonym: "reduced gonadotrope number" EXACT []
synonym: "reduced gonadotrophic hormone secreting cell number" EXACT []
synonym: "reduced LH cell number" NARROW []
synonym: "reduced LH-producing cell number" NARROW []
synonym: "reduced LH-secreting cell number" EXACT []
is_a: MP:0008325 ! abnormal gonadotroph morphology

[Term]
id: MP:0008336
name: absent gonadotrophs
def: "absence of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
synonym: "absent FSH cell" NARROW []
synonym: "absent FSH-producing cell" NARROW []
synonym: "absent FSH-secreting cell" NARROW []
synonym: "absent gonadotrope" EXACT []
synonym: "absent gonadotrophic hormone secreting cell" EXACT []
synonym: "absent LH cell" NARROW []
synonym: "absent LH-producing cell" NARROW []
synonym: "absent LH-secreting cell" EXACT []
is_a: MP:0008335 ! decreased gonadotroph cell number

[Term]
id: MP:0008337
name: increased thyrotroph cell number
def: "greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
synonym: "increased pituitary TSH-producing cell number" EXACT []
synonym: "increased pituitary TSH-secreting cell number" EXACT []
synonym: "increased thymotrope number" EXACT []
synonym: "increased thyreotroph number" EXACT []
synonym: "increased thyroid-hormone secreting cell number" RELATED []
synonym: "increased thyrotrope number" EXACT []
synonym: "increased TSH cell number" EXACT []
synonym: "thyrotrope hyperplasia" EXACT []
synonym: "thyrotroph cell hyperplasia" EXACT []
synonym: "thyrotroph hyperplasia" EXACT []
is_a: MP:0008326 ! abnormal thyrotroph morphology

[Term]
id: MP:0008338
name: decreased thyrotroph cell number
def: "reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
synonym: "decreased pituitary TSH-producing cell number" EXACT []
synonym: "decreased pituitary TSH-secreting cell number" EXACT []
synonym: "decreased thymotrope number" EXACT []
synonym: "decreased thyreotroph number" EXACT []
synonym: "decreased thyroid-hormone secreting cell number" RELATED []
synonym: "decreased thyrotrope number" EXACT []
synonym: "decreased TSH cell number" EXACT []
synonym: "reduced pituitary TSH-producing cell number" EXACT []
synonym: "reduced pituitary TSH-secreting cell number" EXACT []
synonym: "reduced thymotrope number" EXACT []
synonym: "reduced thyreotroph number" EXACT []
synonym: "reduced thyroid-hormone secreting cell number" RELATED []
synonym: "reduced thyrotrope number" EXACT []
synonym: "reduced TSH cell number" EXACT []
synonym: "thyrotroph cell hypoplasia" EXACT []
synonym: "thyrotroph hypoplasia" EXACT []
is_a: MP:0008326 ! abnormal thyrotroph morphology

[Term]
id: MP:0008339
name: absent thyrotrophs
def: "absence of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
synonym: "absent pituitary TSH-producing cell" EXACT []
synonym: "absent pituitary TSH-secreting cell" EXACT []
synonym: "absent thymotrope" EXACT []
synonym: "absent thyreotroph" EXACT []
synonym: "absent thyroid-hormone secreting cell" RELATED []
synonym: "absent thyrotrope" EXACT []
synonym: "absent TSH cell" EXACT []
is_a: MP:0008338 ! decreased thyrotroph cell number

[Term]
id: MP:0008340
name: increased corticotroph cell number
def: "greater number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
synonym: "corticotrope hyperplasia" EXACT []
synonym: "corticotroph cell hyperplasia" EXACT []
synonym: "corticotroph hyperplasia" EXACT []
synonym: "increased adrenocorticotrophic hormone secreting cell number" EXACT []
synonym: "increased adrenocorticotropic hormone secreting cell number" EXACT []
synonym: "increased corticotrope number" EXACT []
synonym: "increased corticotrophin hormone secreting cell number" EXACT []
synonym: "increased corticotropin hormone secreting cell number" EXACT []
synonym: "increased pituitary ACTH-producing cell number" EXACT []
synonym: "increased pituitary ACTH-secreting cell number" EXACT []
synonym: "increased pituitary adrenocorticotropin-secreting cell number" EXACT []
is_a: MP:0008327 ! abnormal corticotroph morphology

[Term]
id: MP:0008341
name: decreased corticotroph cell number
def: "reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
synonym: "corticotroph cell hypoplasia" EXACT []
synonym: "corticotroph hypoplasia" EXACT []
synonym: "decreased adrenocorticotrophic hormone secreting cell number" EXACT []
synonym: "decreased adrenocorticotropic hormone secreting cell number" EXACT []
synonym: "decreased corticotrope number" EXACT []
synonym: "decreased corticotrophin hormone secreting cell number" EXACT []
synonym: "decreased corticotropin hormone secreting cell number" EXACT []
synonym: "decreased pituitary ACTH-producing cell number" EXACT []
synonym: "decreased pituitary ACTH-secreting cell number" EXACT []
synonym: "decreased pituitary adrenocorticotropin-secreting cell number" EXACT []
synonym: "reduced adrenocorticotrophic hormone secreting cell number" EXACT []
synonym: "reduced adrenocorticotropic hormone secreting cell number" EXACT []
synonym: "reduced corticotrope number" EXACT []
synonym: "reduced corticotrophin hormone secreting cell number" EXACT []
synonym: "reduced corticotropin hormone secreting cell number" EXACT []
synonym: "reduced pituitary ACTH-producing cell number" EXACT []
synonym: "reduced pituitary ACTH-secreting cell number" EXACT []
synonym: "reduced pituitary adrenocorticotropin-secreting cell number" EXACT []
is_a: MP:0008327 ! abnormal corticotroph morphology

[Term]
id: MP:0008342
name: absent corticotrophs
def: "absence of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
synonym: "absent adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "absent adrenocorticotropic hormone secreting cell" EXACT []
synonym: "absent corticotrope" EXACT []
synonym: "absent corticotrophin hormone secreting cell" EXACT []
synonym: "absent corticotropin hormone secreting cell" EXACT []
synonym: "absent pituitary ACTH-producing cell" EXACT []
synonym: "absent pituitary ACTH-secreting cell" EXACT []
synonym: "absent pituitary adrenocorticotropin-secreting cell" EXACT []
is_a: MP:0008341 ! decreased corticotroph cell number

[Term]
id: MP:0008343
name: abnormal gamma-delta T cell morphology
def: "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "abnormal gamma-delta T lymphocyte morphology" EXACT []
synonym: "abnormal gamma-delta T-cell morphology" EXACT []
synonym: "abnormal gamma-delta T-lymphocyte morphology" EXACT []
synonym: "abnormal TCRgd cell morphology" EXACT []
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0008344
name: abnormal mature gamma-delta T cell morphology
def: "any structural anomaly of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "abnormal mature gamma-delta T lymphocyte morphology" EXACT []
synonym: "abnormal mature gamma-delta T-cell morphology" EXACT []
synonym: "abnormal mature gamma-delta T-lymphocyte morphology" EXACT []
is_a: MP:0008343 ! abnormal gamma-delta T cell morphology

[Term]
id: MP:0008345
name: abnormal gamma-delta T cell number
def: "anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "abnormal gamma-delta T lymphocyte number" EXACT []
synonym: "abnormal gamma-delta T-cell number" EXACT []
synonym: "abnormal gamma-delta T-lymphocyte number" EXACT []
is_a: MP:0006387 ! abnormal T cell number
is_a: MP:0008343 ! abnormal gamma-delta T cell morphology

[Term]
id: MP:0008346
name: increased gamma-delta T cell number
def: "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "increased gamma-delta T lymphocyte number" EXACT []
synonym: "increased gamma-delta T-cell number" EXACT []
synonym: "increased gamma-delta T-lymphocyte number" EXACT []
is_a: MP:0005015 ! increased T cell number
is_a: MP:0008345 ! abnormal gamma-delta T cell number

[Term]
id: MP:0008347
name: decreased gamma-delta T cell number
def: "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "decreased gamma-delta T lymphocyte number" EXACT []
synonym: "decreased gamma-delta T-cell number" EXACT []
synonym: "decreased gamma-delta T-lymphocyte number" EXACT []
synonym: "reduced gamma-delta T lymphocyte number" EXACT []
synonym: "reduced gamma-delta T-cell number" EXACT []
synonym: "reduced gamma-delta T-lymphocyte number" EXACT []
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0008345 ! abnormal gamma-delta T cell number

[Term]
id: MP:0008348
name: absent gamma-delta T cells
def: "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "absent gamma-delta T lymphocyte" EXACT []
synonym: "absent gamma-delta T-cell" EXACT []
synonym: "absent gamma-delta T-lymphocyte" EXACT []
is_a: MP:0008347 ! decreased gamma-delta T cell number

[Term]
id: MP:0008349
name: abnormal gamma-delta intraepithelial T cell morphology
def: "any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
synonym: "abnormal gamma-delta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal gamma-delta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal gamma-delta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
is_a: MP:0008344 ! abnormal mature gamma-delta T cell morphology
is_a: MP:0008894 ! abnormal intraepithelial T cell morphology

[Term]
id: MP:0008350
name: increased gamma-delta intraepithelial T cell number
def: "greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
synonym: "increased gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "increased gamma-delta intraepithelial T-cell number" EXACT []
synonym: "increased gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "increased IEL number" BROAD []
synonym: "increased intraepithelial lymphocyte number" BROAD []
is_a: MP:0008349 ! abnormal gamma-delta intraepithelial T cell morphology
is_a: MP:0008353 ! increased mature gamma-delta T cell number
is_a: MP:0008895 ! abnormal intraepithelial T cell number

[Term]
id: MP:0008351
name: decreased gamma-delta intraepithelial T cell number
def: "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
synonym: "decreased gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "decreased gamma-delta intraepithelial T-cell number" EXACT []
synonym: "decreased gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "decreased IEL number" BROAD []
synonym: "decreased intraepithelial lymphocyte number" BROAD []
synonym: "reduced gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "reduced gamma-delta intraepithelial T-cell number" EXACT []
synonym: "reduced gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "reduced IEL number" BROAD []
synonym: "reduced intraepithelial lymphocyte number" BROAD []
is_a: MP:0008349 ! abnormal gamma-delta intraepithelial T cell morphology
is_a: MP:0008354 ! decreased mature gamma-delta T cell number
is_a: MP:0008895 ! abnormal intraepithelial T cell number

[Term]
id: MP:0008352
name: absent gamma-delta intraepithelial T cell
def: "absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
synonym: "absent gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "absent gamma-delta intraepithelial T-cell" EXACT []
synonym: "absent gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "absent IEL" BROAD []
synonym: "absent intraepithelial lymphocyte" BROAD []
is_a: MP:0008351 ! decreased gamma-delta intraepithelial T cell number

[Term]
id: MP:0008353
name: increased mature gamma-delta T cell number
def: "increased number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "increased mature gamma-delta T lymphocyte number" EXACT []
synonym: "increased mature gamma-delta T-cell number" EXACT []
synonym: "increased mature gamma-delta T-lymphocyte number" EXACT []
is_a: MP:0008344 ! abnormal mature gamma-delta T cell morphology
is_a: MP:0008346 ! increased gamma-delta T cell number

[Term]
id: MP:0008354
name: decreased mature gamma-delta T cell number
def: "reduced number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "decreased mature gamma-delta T lymphocyte number" EXACT []
synonym: "decreased mature gamma-delta T-cell number" EXACT []
synonym: "decreased mature gamma-delta T-lymphocyte number" EXACT []
synonym: "reduced mature gamma-delta T lymphocyte number" EXACT []
synonym: "reduced mature gamma-delta T-cell number" EXACT []
synonym: "reduced mature gamma-delta T-lymphocyte number" EXACT []
is_a: MP:0008344 ! abnormal mature gamma-delta T cell morphology
is_a: MP:0008347 ! decreased gamma-delta T cell number

[Term]
id: MP:0008355
name: absent mature gamma-delta T cells
def: "absence of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "absent mature gamma-delta T lymphocyte" EXACT []
synonym: "absent mature gamma-delta T-cell" EXACT []
synonym: "absent mature gamma-delta T-lymphocyte" EXACT []
is_a: MP:0008354 ! decreased mature gamma-delta T cell number

[Term]
id: MP:0008356
name: abnormal gamma-delta T cell differentiation
def: "atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]
comment: Note that gamma-delta T cell have both thymic and extrathymic differentiation pathways.
synonym: "abnormal gamma-delta T lymphocyte differentiation" EXACT []
synonym: "abnormal gamma-delta T-cell differentiation" EXACT []
synonym: "abnormal gamma-delta T-lymphocyte differentiation" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation
is_a: MP:0008343 ! abnormal gamma-delta T cell morphology

[Term]
id: MP:0008357
name: abnormal CD4-positive, gamma-delta intraepithelial T cell morphology
def: "any structural anomaly of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "abnormal CD4-positive, gamma-delta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal CD4-positive, gamma-delta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal CD4-positive, gamma-delta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
synonym: "abnormal intraepithelial lymphocyte morphology" BROAD []
is_a: MP:0008349 ! abnormal gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008358
name: increased CD4-positive, gamma-delta intraepithelial T cell number
def: "greater number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "increased CD4-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "increased CD4-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "increased CD4-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "increased IEL number" BROAD []
synonym: "increased intraepithelial lymphocyte number" BROAD []
is_a: MP:0008350 ! increased gamma-delta intraepithelial T cell number
is_a: MP:0008357 ! abnormal CD4-positive, gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008359
name: decreased CD4-positive, gamma-delta intraepithelial T cell number
def: "reduced number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "decreased CD4-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "decreased CD4-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "decreased CD4-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "decreased IEL number" BROAD []
synonym: "decreased intraepithelial lymphocyte number" BROAD []
synonym: "reduced CD4-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "reduced CD4-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "reduced CD4-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "reduced IEL number" BROAD []
synonym: "reduced intraepithelial lymphocyte number" BROAD []
is_a: MP:0008351 ! decreased gamma-delta intraepithelial T cell number
is_a: MP:0008357 ! abnormal CD4-positive, gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008360
name: absent CD4-positive, gamma-delta intraepithelial T cells
def: "absence of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "absent CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "absent CD4-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "absent CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "absent IEL" BROAD []
synonym: "absent intraepithelial lymphocyte" BROAD []
is_a: MP:0008359 ! decreased CD4-positive, gamma-delta intraepithelial T cell number

[Term]
id: MP:0008361
name: abnormal CD8-positive, gamma-delta intraepithelial T cell morphology
def: "any structural anomaly of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "abnormal CD8-positive, gamma-delta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, gamma-delta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal CD8-positive, gamma-delta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
synonym: "abnormal intraepithelial lymphocyte morphology" BROAD []
is_a: MP:0008349 ! abnormal gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008362
name: increased CD8-positive, gamma-delta intraepithelial T cell number
def: "greater number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "increased CD8-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "increased CD8-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "increased CD8-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "increased IEL number" BROAD []
synonym: "increased intraepithelial lymphocyte number" BROAD []
is_a: MP:0008350 ! increased gamma-delta intraepithelial T cell number
is_a: MP:0008361 ! abnormal CD8-positive, gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008363
name: decreased CD8-positive, gamma-delta intraepithelial T cell number
def: "reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "decreased CD8-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "decreased CD8-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "decreased CD8-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "decreased IEL number" BROAD []
synonym: "decreased intraepithelial lymphocyte number" BROAD []
synonym: "reduced CD8-positive, gamma-delta intraepithelial T lymphocyte number" EXACT []
synonym: "reduced CD8-positive, gamma-delta intraepithelial T-cell number" EXACT []
synonym: "reduced CD8-positive, gamma-delta intraepithelial T-lymphocyte number" EXACT []
synonym: "reduced IEL number" BROAD []
synonym: "reduced intraepithelial lymphocyte number" BROAD []
is_a: MP:0008351 ! decreased gamma-delta intraepithelial T cell number
is_a: MP:0008361 ! abnormal CD8-positive, gamma-delta intraepithelial T cell morphology

[Term]
id: MP:0008364
name: absent CD8-positive, gamma-delta intraepithelial T cells
def: "absence of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
synonym: "absent CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "absent CD8-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "absent CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "absent IEL" BROAD []
synonym: "absent intraepithelial lymphocyte" BROAD []
is_a: MP:0008363 ! decreased CD8-positive, gamma-delta intraepithelial T cell number

[Term]
id: MP:0008365
name: adenohypophysis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the adenohypophysis, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "adenophysis hypoplasia" EXACT []
synonym: "hypoplastic adenohypophysis" EXACT []
synonym: "hypoplastic anterior lobe of the pituitary" EXACT []
synonym: "pituitary anterior lobe hypoplasia" EXACT []
is_a: MP:0008321 ! small adenohypophysis

[Term]
id: MP:0008366
name: enlarged adenohypophysis
def: "increased size of the anterior part of the pituitary that secretes a variety of hormones" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased adenohypophysis size" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0008367
name: absent pituitary intermediate lobe
def: "absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of pituitary intermediate lobe" EXACT []
is_a: MP:0008130 ! abnormal pituitary intermediate lobe morphology

[Term]
id: MP:0008368
name: small pituitary intermediate lobe
def: "reduced size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased pituitary intermediate lobe size" EXACT []
synonym: "reduced pituitary intermediate lobe size" EXACT []
is_a: MP:0008130 ! abnormal pituitary intermediate lobe morphology

[Term]
id: MP:0008369
name: pituitary intermediate lobe hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pituitary intermediate lobe, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic pituitary intermediate lobe" EXACT []
is_a: MP:0008368 ! small pituitary intermediate lobe

[Term]
id: MP:0008370
name: enlarged pituitary intermediate lobe
def: "increased size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pituitary intermediate lobe size" EXACT []
is_a: MP:0008130 ! abnormal pituitary intermediate lobe morphology

[Term]
id: MP:0008371
name: pituitary intermediate lobe hyperplasia
def: "increase in the number of normal cells in normal arrangement in the pituitary intermediate lobe, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic pituitary intermediate lobe" EXACT []
is_a: MP:0008370 ! enlarged pituitary intermediate lobe

[Term]
id: MP:0008372
name: small malleus
def: "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased malleus size" EXACT []
synonym: "reduced malleus size" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology
is_a: MP:0030123 ! small middle ear ossicles

[Term]
id: MP:0008373
name: short malleus
def: "reduced length of the largest of the three auditory ossicles, which resembles a club or hammer" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased malleus length" EXACT []
is_a: MP:0008372 ! small malleus

[Term]
id: MP:0008374
name: abnormal malleus manubrium morphology
def: "any structural anomaly in the handle of the malleus, which extends downward, inward, and backward from the neck of the malleus and is embedded throughout its length in the tympanic membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal handle of malleus morphology" EXACT []
synonym: "abnormal malleal manubrium morphology" EXACT []
synonym: "abnormal malleus handle morphology" EXACT []
synonym: "abnormal manubrium mallei morphology" EXACT []
synonym: "abnormal manubrium morphology" BROAD []
synonym: "abnormal manubrium of malleus morphology" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology

[Term]
id: MP:0008375
name: short malleus manubrium
def: "reduced length of the handle of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased malleus manubrium length" EXACT []
synonym: "reduced malleus manubrium length" EXACT []
synonym: "short handle of malleus" EXACT []
synonym: "short malleal manubrium" EXACT []
synonym: "short malleus handle" EXACT []
synonym: "short manubrium" BROAD []
synonym: "short manubrium mallei" EXACT []
synonym: "short manubrium of malleus" EXACT []
is_a: MP:0008376 ! small malleus manubrium

[Term]
id: MP:0008376
name: small malleus manubrium
def: "reduced size of the handle of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased malleus manubrium size" EXACT []
synonym: "reduced malleus manubrium size" EXACT []
synonym: "small handle of malleus" EXACT []
synonym: "small malleal manubrium" EXACT []
synonym: "small malleus handle" EXACT []
synonym: "small manubrium" BROAD []
synonym: "small manubrium mallei" EXACT []
synonym: "small manubrium of malleus" EXACT []
is_a: MP:0008374 ! abnormal malleus manubrium morphology

[Term]
id: MP:0008377
name: absent malleus manubrium
def: "absence of the handle of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent handle of malleus" EXACT []
synonym: "absent malleal manubrium" EXACT []
synonym: "absent malleus handle" EXACT []
synonym: "absent manubrium" BROAD []
synonym: "absent manubrium mallei" EXACT []
synonym: "absent manubrium of malleus" EXACT []
is_a: MP:0008374 ! abnormal malleus manubrium morphology

[Term]
id: MP:0008378
name: small malleus processus brevis
def: "reduced size of the projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased malleus processus brevis size" EXACT []
synonym: "reduced malleus processus brevis size" EXACT []
synonym: "small malleal processus brevis" EXACT []
is_a: MP:0010324 ! abnormal malleus processus brevis morphology

[Term]
id: MP:0008379
name: absent malleus head
def: "absence of the rounded portion of the malleus articulating with the body of the incus" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent caput mallei" EXACT []
synonym: "absent head of malleus" EXACT []
is_a: MP:0010325 ! abnormal malleus head morphology

[Term]
id: MP:0008380
name: abnormal gonial bone morphology
def: "any structural anomaly of the investing bone that lies on the surface of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal gonium" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology

[Term]
id: MP:0008381
name: absent gonial bone
def: "absence of the investing bone that normally lies on the surface of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent gonium" EXACT []
is_a: MP:0000040 ! absent middle ear ossicles
is_a: MP:0008380 ! abnormal gonial bone morphology

[Term]
id: MP:0008382
name: gonial bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the gonial bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic gonium" EXACT []
is_a: MP:0030124 ! middle ear ossicle hypoplasia
is_a: MP:0030125 ! small gonial bone

[Term]
id: MP:0008383
name: enlarged gonial bone
def: "increased size of the investing bone that lies on the surface of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged gonium" EXACT []
synonym: "increased gonial bone size" EXACT []
is_a: MP:0008380 ! abnormal gonial bone morphology

[Term]
id: MP:0008384
name: absent nasal capsule
def: "absence of the cartilage around the developing nasal cavity of the embryo" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004726 ! abnormal nasal capsule morphology

[Term]
id: MP:0008385
name: absent basisphenoid bone
def: "absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000106 ! abnormal basisphenoid bone morphology

[Term]
id: MP:0008386
name: absent styloid process
def: "absence of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone to join the tympanic portion" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008023 ! abnormal styloid process morphology

[Term]
id: MP:0008387
name: hypochromic anemia
def: "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs" [https://orcid.org/0000-0003-3691-0324, https://orcid.org/0000-0003-4606-0597]
synonym: "hypochromic anaemia" EXACT []
synonym: "normocytic hypochromic anaemia" NARROW []
synonym: "normocytic hypochromic anemia" NARROW []
is_a: MP:0001577 ! anemia

[Term]
id: MP:0008388
name: hypochromic microcytic anemia
def: "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypochromic microcytic anaemia" EXACT []
synonym: "microcytic hypochromic anaemia" EXACT []
synonym: "microcytic hypochromic anemia" EXACT []
is_a: MP:0002810 ! microcytic anemia
is_a: MP:0008387 ! hypochromic anemia

[Term]
id: MP:0008389
name: hypochromic macrocytic anemia
def: "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypochromic macrocytic anaemia" EXACT []
synonym: "macrocytic hypochromic anaemia" EXACT []
synonym: "macrocytic hypochromic anemia" EXACT []
is_a: MP:0002811 ! macrocytic anemia
is_a: MP:0008387 ! hypochromic anemia

[Term]
id: MP:0008390
name: abnormal primordial germ cell proliferation
def: "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0020363 ! abnormal germ cell physiology

[Term]
id: MP:0008391
name: abnormal primordial germ cell morphology
def: "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal PGC morphology" EXACT []
xref: CL:0000670
is_a: MP:0002208 ! abnormal germ cell morphology

[Term]
id: MP:0008392
name: decreased primordial germ cell number
def: "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased PGC number" EXACT []
synonym: "reduced PGC number" EXACT []
synonym: "reduced primordial germ cell number" EXACT []
is_a: MP:0002209 ! decreased germ cell number
is_a: MP:0008391 ! abnormal primordial germ cell morphology

[Term]
id: MP:0008393
name: absent primordial germ cells
def: "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent PGCs" EXACT []
is_a: MP:0008392 ! decreased primordial germ cell number

[Term]
id: MP:0008394
name: increased primordial germ cell number
def: "greater number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased PGC number" EXACT []
is_a: MP:0008391 ! abnormal primordial germ cell morphology

[Term]
id: MP:0008395
name: abnormal osteoblast differentiation
alt_id: MP:0005008
def: "atypical production of or inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
synonym: "abnormal osteoblast formation" EXACT []
synonym: "abnormal osteoplast formation" EXACT []
is_a: MP:0002113 ! abnormal skeleton development
is_a: MP:0004986 ! abnormal osteoblast morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0008396
name: abnormal osteoclast differentiation
alt_id: MP:0000059
def: "atypical production of or inability to produce the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue" [CL:0000092]
synonym: "abnormal chondroclast differentiation" RELATED []
synonym: "abnormal osteoclast formation" EXACT []
synonym: "abnormal osteophage formation" EXACT []
is_a: MP:0002113 ! abnormal skeleton development
is_a: MP:0004982 ! abnormal osteoclast morphology
is_a: MP:0005076 ! abnormal cell differentiation

[Term]
id: MP:0008397
name: abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology
def: "any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
synonym: "abnormal CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte morphology" EXACT []
synonym: "abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-cell morphology" EXACT []
synonym: "abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte morphology" EXACT []
synonym: "abnormal CD4-positive, CD25-positive, alpha-beta Treg morphology" EXACT []
synonym: "abnormal suppressor T cell morphology" BROAD []
synonym: "abnormal suppressor T lymphocyte morphology" BROAD []
synonym: "abnormal suppressor T-cell morphology" BROAD []
synonym: "abnormal suppressor T-lymphocyte morphology" BROAD []
xref: CL:0000792
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology
is_a: MP:0004941 ! abnormal regulatory T cell morphology

[Term]
id: MP:0008398
name: abnormal CD8-positive, alpha-beta regulatory T cell morphology
def: "any structural anomaly of a CD8-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
synonym: "abnormal CD8-positive, alpha-beta regulatory T lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta regulatory T-cell morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta regulatory T-lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta Treg morphology" EXACT []
synonym: "abnormal suppressor T cell morphology" BROAD []
synonym: "abnormal suppressor T lymphocyte morphology" BROAD []
synonym: "abnormal suppressor T-cell morphology" BROAD []
synonym: "abnormal suppressor T-lymphocyte morphology" BROAD []
xref: CL:0000795
is_a: MP:0004941 ! abnormal regulatory T cell morphology
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology

[Term]
id: MP:0008399
name: abnormal alpha-beta intraepithelial T cell morphology
def: "any structural anomaly of an alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
synonym: "abnormal alpha-beta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal alpha-beta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal alpha-beta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
synonym: "abnormal intraepithelial lymphocyte morphology" BROAD []
xref: CL:0000797
is_a: MP:0002435 ! abnormal effector T cell morphology
is_a: MP:0008894 ! abnormal intraepithelial T cell morphology
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology

[Term]
id: MP:0008400
name: abnormal CD4-positive, alpha-beta intraepithelial T cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
synonym: "abnormal CD4-positive, alpha-beta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal CD4-positive, alpha-beta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal CD4-positive, alpha-beta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
synonym: "abnormal intraepithelial lymphocyte morphology" BROAD []
xref: CL:0000793
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology
is_a: MP:0008399 ! abnormal alpha-beta intraepithelial T cell morphology

[Term]
id: MP:0008401
name: abnormal CD8 positive, alpha-beta intraepithelial T cell morphology
def: "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
synonym: "abnormal CD8-positive, alpha-beta intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta intraepithelial T-cell morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta intraepithelial T-lymphocyte morphology" EXACT []
synonym: "abnormal IEL morphology" BROAD []
xref: CL:0000796
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology
is_a: MP:0008399 ! abnormal alpha-beta intraepithelial T cell morphology

[Term]
id: MP:0008402
name: increased cellular sensitivity to alkylating agents
def: "greater incidence of cell death following exposure to agents that cause DNA damage via the addition of alkyl groups to any or all of the bases of DNA" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to alkylating agents" EXACT []
synonym: "increased cellular susceptibility to alkylating agents" EXACT []
is_a: MP:0014040 ! increased cellular sensitivity to DNA damaging agents

[Term]
id: MP:0008403
name: decreased cellular sensitivity to alkylating agents
def: "reduced incidence of cell death following exposure to agents that cause DNA damage via the addition of alkyl groups to any or all of the bases of DNA" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular susceptibility to alkylating agents" EXACT []
synonym: "increased cellular resistance to alkylating agents" EXACT []
synonym: "reduced cellular sensitivity to alkylating agents" EXACT []
is_a: MP:0014042 ! decreased cellular sensitivity to DNA damaging agents

[Term]
id: MP:0008404
name: increased cellular sensitivity to methylmethanesulfonate
def: "greater incidence of cell death following exposure to methylmethanesulfonate" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to methylmethanesulfonate" EXACT []
synonym: "decreased cellular resistance to MMS" EXACT []
synonym: "increased cellular sensitivity to MMS" EXACT []
synonym: "increased cellular susceptibility to methylmethanesulfonate" EXACT []
synonym: "increased cellular susceptibility to MMS" EXACT []
is_a: MP:0008402 ! increased cellular sensitivity to alkylating agents

[Term]
id: MP:0008405
name: decreased cellular sensitivity to methylmethanesulfonate
def: "reduced incidence of cell death following exposure to methylmethanesulfonate" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular sensitivity to MMS" EXACT []
synonym: "decreased cellular susceptibility to methylmethanesulfonate" EXACT []
synonym: "decreased cellular susceptibility to MMS" EXACT []
synonym: "increased cellular resistance to methylmethanesulfonate" EXACT []
synonym: "increased cellular resistance to MMS" EXACT []
synonym: "reduced cellular sensitivity to methylmethanesulfonate" EXACT []
synonym: "reduced cellular sensitivity to MMS" EXACT []
is_a: MP:0008403 ! decreased cellular sensitivity to alkylating agents

[Term]
id: MP:0008406
name: increased cellular sensitivity to hydrogen peroxide
def: "greater incidence of cell death following exposure to hydrogen peroxide" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to H2O2" EXACT []
synonym: "decreased cellular resistance to hydrogen peroxide" EXACT []
synonym: "increased cellular sensitivity to H2O2" EXACT []
synonym: "increased cellular susceptibility to H2O2" EXACT []
synonym: "increased cellular susceptibility to hydrogen peroxide" EXACT []
is_a: MP:0008412 ! increased cellular sensitivity to oxidative stress

[Term]
id: MP:0008407
name: decreased cellular sensitivity to hydrogen peroxide
def: "reduced incidence of cell death following exposure to hydrogen peroxide" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular sensitivity to H2O2" EXACT []
synonym: "decreased cellular susceptibility to H2O2" EXACT []
synonym: "increased cellular resistance to H2O2" EXACT []
synonym: "reduced cellular sensitivity to H2O2" EXACT []
synonym: "reduced cellular sensitivity to hydrogen peroxide" EXACT []
is_a: MP:0008413 ! decreased cellular sensitivity to oxidative stress

[Term]
id: MP:0008408
name: decreased cellular sensitivity to hydroxyurea
def: "reduced incidence of cell death following exposure to hydroxyurea" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular susceptibility to hydroxyurea" EXACT []
synonym: "increased cellular resistance to hydroxyurea" EXACT []
synonym: "reduced cellular sensitivity to hydroxyurea" EXACT []
is_a: MP:0008403 ! decreased cellular sensitivity to alkylating agents

[Term]
id: MP:0008409
name: increased cellular sensitivity to hydroxyurea
def: "greater incidence of cell death following exposure to hydroxyurea" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to hydroxyurea" EXACT []
synonym: "increased cellular susceptibility to hydroxyurea" EXACT []
is_a: MP:0008402 ! increased cellular sensitivity to alkylating agents

[Term]
id: MP:0008410
name: increased cellular sensitivity to ultraviolet irradiation
def: "greater incidence of cell death following exposure to ultraviolet irradiation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to ultraviolet irradiation" EXACT []
synonym: "increased cellular susceptibility to ultraviolet irradiation" EXACT []
is_a: MP:0008943 ! increased sensitivity to induced cell death

[Term]
id: MP:0008411
name: decreased cellular sensitivity to ultraviolet irradiation
def: "reduced incidence of cell death following exposure to ultraviolet irradiation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular susceptibility to ultraviolet irradiation" EXACT []
synonym: "increased cellular resistance to ultraviolet irradiation" EXACT []
synonym: "reduced cellular sensitivity to ultraviolet irradiation" EXACT []
is_a: MP:0008944 ! decreased sensitivity to induced cell death

[Term]
id: MP:0008412
name: increased cellular sensitivity to oxidative stress
def: "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular resistance to oxidative stress" EXACT []
synonym: "increased cellular susceptibility to oxidative stress" EXACT []
is_a: MP:0008943 ! increased sensitivity to induced cell death

[Term]
id: MP:0008413
name: decreased cellular sensitivity to oxidative stress
def: "reduced incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cellular susceptibility to oxidative stress" EXACT []
synonym: "increased cellular resistance to oxidative stress" EXACT []
synonym: "reduced cellular sensitivity to oxidative stress" EXACT []
is_a: MP:0008944 ! decreased sensitivity to induced cell death

[Term]
id: MP:0008414
name: abnormal spatial reference memory
def: "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to navigate or perform other behavior using such location cues" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal SRM" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0008415
name: abnormal neurite morphology
def: "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0008416
name: increased somatotroph cell size
def: "excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.937]
synonym: "somatotroph cell hypertrophy" EXACT []
synonym: "somatotroph hypertrophy" EXACT []
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008417
name: decreased somatotroph cell size
def: "reduced growth or small size of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.937]
synonym: "reduced somatotroph cell size" EXACT []
synonym: "somatotroph hypotrophy" EXACT []
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008418
name: abnormal cutaneous elastic fiber morphology
def: "any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cutaneous elastic fibre morphology" EXACT []
synonym: "abnormal dermal elastic fiber morphology" EXACT []
synonym: "abnormal dermal elastic fibre morphology" EXACT []
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0008419
name: abnormal cutaneous microfibril morphology
def: "any structural anomaly of the fiber-like strand of fibrillin that forms the scaffold of the cutaneous elastic fibers found in the extracellular matrix of the skin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008418 ! abnormal cutaneous elastic fiber morphology

[Term]
id: MP:0008420
name: increased thyrotroph cell size
def: "excessive growth or enlargement of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
synonym: "thyrotroph cell hypertrophy" EXACT []
synonym: "thyrotroph hypertrophy" EXACT []
is_a: MP:0008326 ! abnormal thyrotroph morphology

[Term]
id: MP:0008421
name: decreased thyrotroph cell size
def: "reduced growth or small size of an anterior pituitary cell that produces thyroid-stimulating hormone" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.968]
synonym: "reduced thyrotroph cell size" EXACT []
is_a: MP:0008326 ! abnormal thyrotroph morphology

[Term]
id: MP:0008422
name: increased lactotroph cell size
def: "excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces prolactin" [MESH:A06.407.747.608.812]
synonym: "lactotroph cell hypertrophy" EXACT []
synonym: "lactotroph hypertrophy" EXACT []
is_a: MP:0008323 ! abnormal lactotroph morphology

[Term]
id: MP:0008423
name: decreased lactotroph cell size
def: "reduced growth or small size of an acidophilic cell of the anterior pituitary that produces prolactin" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.812]
synonym: "reduced lactotroph cell size" EXACT []
is_a: MP:0008323 ! abnormal lactotroph morphology

[Term]
id: MP:0008424
name: increased gonadotroph cell size
def: "excessive growth or enlargement of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
synonym: "gonadotroph cell hypertrophy" EXACT []
synonym: "gonadotroph hypertrophy" EXACT []
is_a: MP:0008325 ! abnormal gonadotroph morphology

[Term]
id: MP:0008425
name: decreased gonadotroph cell size
def: "reduced growth or small size of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.750]
synonym: "reduced gonadotroph cell size" EXACT []
is_a: MP:0008325 ! abnormal gonadotroph morphology

[Term]
id: MP:0008426
name: increased corticotroph cell size
def: "excessive growth or enlargement of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.500]
synonym: "corticotroph cell hypertrophy" EXACT []
synonym: "corticotroph hypertrophy" EXACT []
is_a: MP:0008327 ! abnormal corticotroph morphology

[Term]
id: MP:0008427
name: decreased corticotroph cell size
def: "reduced growth or small size of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [https://orcid.org/0000-0003-3691-0324, MESH:A06.407.747.608.500]
synonym: "reduced corticotroph cell size" EXACT []
is_a: MP:0008327 ! abnormal corticotroph morphology

[Term]
id: MP:0008428
name: abnormal spatial working memory
def: "anomaly in the ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal SWM" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0008429
name: absent parotid gland
def: "absence of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent external salivary gland morphology" EXACT []
synonym: "absent glandula parotidea morphology" EXACT []
synonym: "absent glandula parotis morphology" EXACT []
is_a: MP:0003452 ! abnormal parotid gland morphology

[Term]
id: MP:0008430
name: short temporal bone squamous part
def: "length reduction of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased squamosal bone length" EXACT []
synonym: "reduced squamosal bone length" EXACT []
synonym: "short squamosal bone" EXACT []
synonym: "short squamous bone" EXACT []
synonym: "short squamous part of temporal bone" EXACT []
synonym: "short squamous temporal bone" EXACT []
synonym: "short temporal squama" EXACT []
is_a: MP:0030121 ! small temporal bone squamous part

[Term]
id: MP:0008431
name: abnormal short-term spatial reference memory
def: "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encounter at that location" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal short term spatial reference memory" EXACT []
synonym: "abnormal short-term SRM" EXACT []
is_a: MP:0008414 ! abnormal spatial reference memory

[Term]
id: MP:0008432
name: abnormal long-term spatial reference memory
def: "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal long term spatial reference memory" RELATED []
synonym: "abnormal long-term SRM" EXACT []
is_a: MP:0008414 ! abnormal spatial reference memory

[Term]
id: MP:0008433
name: abnormal somatotroph cell nucleus
def: "any structural anomaly of a somatotroph cell nucleus" [MGI:llw2]
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008434
name: small somatotroph cell nucleus
def: "decreased size of a somatotroph cell nucleus" [MGI:llw2]
is_a: MP:0008433 ! abnormal somatotroph cell nucleus

[Term]
id: MP:0008435
name: large somatotroph cell nucleus
def: "increased size of a somatotroph cell nucleus" [MGI:llw2]
is_a: MP:0008433 ! abnormal somatotroph cell nucleus

[Term]
id: MP:0008436
name: decreased somatotroph secretory granule number
def: "decreased number of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface" [MGI:llw2]
synonym: "decreased somatotroph secretory vesicle number" EXACT []
synonym: "reduced somatotroph secretory granule number" EXACT []
is_a: MP:0008322 ! abnormal somatotroph morphology

[Term]
id: MP:0008437
name: absent somatotroph secretory granules
def: "absence of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface" [MGI:llw2]
is_a: MP:0008436 ! decreased somatotroph secretory granule number

[Term]
id: MP:0008438
name: abnormal cutaneous collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal dermal collagen fiber morphology" EXACT []
synonym: "abnormal dermal collagen fibre morphology" EXACT []
synonym: "abnormal dermal collagen fibril morphology" EXACT []
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0008439
name: abnormal cortical plate morphology
def: "any structural anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [https://orcid.org/0000-0003-3691-0324, PMID:1812236]
synonym: "abnormal CP morphology" EXACT []
synonym: "abnormal immature cerebral cortex morphology" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0008440
name: abnormal subplate morphology
def: "any structural anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [https://orcid.org/0000-0003-3691-0324, PMID:8210173]
synonym: "abnormal SP morphology" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0008441
name: thin cortical plate
def: "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [https://orcid.org/0000-0003-3691-0324, PMID:1812236]
is_a: MP:0008439 ! abnormal cortical plate morphology

[Term]
id: MP:0008442
name: disorganized cortical plate
def: "derangement of the patterned arrangement of the cortical plate" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised cortical plate" EXACT []
is_a: MP:0008439 ! abnormal cortical plate morphology

[Term]
id: MP:0008443
name: absent subplate
def: "absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [https://orcid.org/0000-0003-3691-0324, PMID:8210173]
is_a: MP:0008440 ! abnormal subplate morphology

[Term]
id: MP:0008444
name: retina cone cell degeneration
def: "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [https://orcid.org/0000-0003-3691-0324, MESH:A08.663.650.650.670.100]
synonym: "retinal cone cell degeneration" EXACT []
is_a: MP:0001006 ! abnormal retina cone cell morphology
is_a: MP:0008450 ! retina photoreceptor degeneration

[Term]
id: MP:0008445
name: increased retina cone cell number
def: "greater number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100]
synonym: "increased number of retinal cone cells" EXACT []
synonym: "increased retinal cone cell number" EXACT []
is_a: MP:0001006 ! abnormal retina cone cell morphology
is_a: MP:0006070 ! increased retina photoreceptor cell number

[Term]
id: MP:0008446
name: decreased retina cone cell number
def: "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [https://orcid.org/0000-0003-3691-0324, MESH:A08.663.650.650.670.100]
synonym: "decreased number of retinal cone cells" EXACT []
synonym: "decreased retinal cone cell number" EXACT []
synonym: "reduced retina cone cell number" EXACT []
synonym: "reduced retinal cone cell number" EXACT []
is_a: MP:0001006 ! abnormal retina cone cell morphology
is_a: MP:0001327 ! decreased retina photoreceptor cell number

[Term]
id: MP:0008447
name: absent retina cone cells
def: "absence of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100]
synonym: "absent retinal cone cells" EXACT []
is_a: MP:0008446 ! decreased retina cone cell number

[Term]
id: MP:0008448
name: abnormal retina cone cell inner segment morphology
def: "any structural anomaly of the retinal cone cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal retinal cone cell inner segment morphology" EXACT []
is_a: MP:0001006 ! abnormal retina cone cell morphology
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008449
name: abnormal retina cone cell outer segment morphology
def: "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal COS morphology" EXACT []
synonym: "abnormal retinal cone cell outer segment morphology" EXACT []
is_a: MP:0001006 ! abnormal retina cone cell morphology
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology

[Term]
id: MP:0008450
name: retina photoreceptor degeneration
def: "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [https://orcid.org/0000-0003-3691-0324, MESH:A08.663.650.650]
synonym: "retinal photoreceptor degeneration" EXACT []
is_a: MP:0001004 ! abnormal retina photoreceptor morphology
is_a: MP:0003224 ! neuron degeneration

[Term]
id: MP:0008451
name: retina rod cell degeneration
def: "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
synonym: "retinal rod cell degeneration" EXACT []
is_a: MP:0001005 ! abnormal retina rod cell morphology
is_a: MP:0008450 ! retina photoreceptor degeneration

[Term]
id: MP:0008452
name: increased retina rod cell number
def: "greater number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
synonym: "increased number of retinal rod cells" EXACT []
synonym: "increased retinal rod cell number" EXACT []
is_a: MP:0001005 ! abnormal retina rod cell morphology
is_a: MP:0006070 ! increased retina photoreceptor cell number

[Term]
id: MP:0008453
name: decreased retina rod cell number
def: "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
synonym: "decreased number of retinal rod cells" EXACT []
synonym: "decreased retinal rod cell number" EXACT []
synonym: "reduced retina rod cell number" EXACT []
synonym: "reduced retinal rod cell number" EXACT []
is_a: MP:0001005 ! abnormal retina rod cell morphology
is_a: MP:0001327 ! decreased retina photoreceptor cell number

[Term]
id: MP:0008454
name: absent retina rod cells
def: "absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
synonym: "absent retinal rod cells" EXACT []
is_a: MP:0008453 ! decreased retina rod cell number

[Term]
id: MP:0008455
name: abnormal retina rod cell inner segment morphology
def: "any structural anomaly of the retinal rod cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal retinal rod cell inner segment morphology" EXACT []
is_a: MP:0001005 ! abnormal retina rod cell morphology
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008456
name: abnormal retina rod cell outer segment morphology
def: "any structural anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal retinal rod cell outer segment morphology" EXACT []
synonym: "abnormal ROS morphology" EXACT []
is_a: MP:0001005 ! abnormal retina rod cell morphology
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology

[Term]
id: MP:0008457
name: abnormal cortical intermediate zone morphology
def: "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
synonym: "abnormal IZ morphology" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0008458
name: abnormal cortical ventricular zone morphology
def: "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal VZ morphology" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0008459
name: abnormal circulating pancreatic peptide level
def: "anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8, MESH:D06.472.699.587.700]
synonym: "abnormal blood pancreatic polypeptide amount" EXACT []
synonym: "abnormal circulating pancreatic polypeptide hormone level" EXACT []
synonym: "abnormal circulating pancreatic polypeptide level" EXACT []
synonym: "abnormal circulating pancreatic prohormone level" EXACT []
synonym: "abnormal circulating PP level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0008460
name: absent dorsal root ganglion
def: "absence of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [https://orcid.org/0000-0003-3691-0324, MESH:A08.340.390.340]
synonym: "absent dorsal root ganglia" EXACT []
synonym: "absent DRGs" EXACT []
synonym: "absent spinal ganglia" RELATED []
synonym: "absent spinal ganglion" RELATED []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0008461
name: left atrial isomerism
def: "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body" [https://orcid.org/0000-0003-4606-0597]
subset: CvDC_Terms
is_a: MP:0000542 ! left-sided isomerism
is_a: MP:0006065 ! abnormal heart position or orientation
is_a: MP:0014319 ! abnormal heart atrium arrangement

[Term]
id: MP:0008462
name: abnormal medium spiny neuron morphology
def: "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
synonym: "abnormal MSN morphology" EXACT []
synonym: "abnormal striatal neuron morphology" BROAD []
is_a: MP:0002882 ! abnormal neuron morphology
is_a: MP:0004077 ! abnormal striatum morphology

[Term]
id: MP:0008463
name: abnormal peripheral lymph node morphology
def: "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal external lymph node morphology" EXACT []
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0008464
name: absent peripheral lymph nodes
def: "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0008465
name: absent mesenteric lymph nodes
def: "absence of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8]
is_a: MP:0005232 ! abnormal mesenteric lymph node morphology

[Term]
id: MP:0008466
name: enlarged mesenteric lymph nodes
def: "increased size of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8]
synonym: "increased mesenteric lymph node size" EXACT []
synonym: "mesenteric lymphoadenopathy" RELATED []
is_a: MP:0005232 ! abnormal mesenteric lymph node morphology

[Term]
id: MP:0008467
name: absent proprioceptive neurons
def: "absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004297 ! abnormal proprioceptive neuron morphology

[Term]
id: MP:0008468
name: absent muscle spindles
def: "absence of the sensory organs in muscle that are involved in the stretch reflex" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "absent Kuhne spindle" EXACT []
synonym: "absent neuromuscular spindle" EXACT []
is_a: MP:0008486 ! decreased muscle spindle number

[Term]
id: MP:0008469
name: abnormal protein level
def: "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0008470
name: abnormal spleen B cell follicle morphology
def: "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
synonym: "abnormal spleen B lymphocyte follicle morphology" EXACT []
synonym: "abnormal splenic B cell follicle morphology" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0008471
name: abnormal spleen primary B follicle morphology
def: "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
synonym: "abnormal splenic primary B cell morphology" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology

[Term]
id: MP:0008472
name: abnormal spleen secondary B follicle morphology
def: "any structural anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [PMID:17495967]
synonym: "abnormal splenic secondary B cell follicle morphology" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology

[Term]
id: MP:0008473
name: abnormal spleen follicular dendritic cell network
def: "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [https://orcid.org/0000-0003-3691-0324]
comment: The follicular dendritic cell network is often visualized by using the monoclonal antibody FDC-M2.
synonym: "abnormal FDC network" BROAD []
synonym: "abnormal FDCN" BROAD []
synonym: "abnormal spleen FDC network" EXACT []
synonym: "abnormal splenic follicular dendritic cell network" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology

[Term]
id: MP:0008474
name: absent spleen germinal center
def: "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "absent spleen follicle center" EXACT []
synonym: "absent spleen follicle centre" EXACT []
synonym: "absent spleen GC" EXACT []
synonym: "absent spleen germinal centre" EXACT []
synonym: "absent splenic germinal center" EXACT []
synonym: "absent splenic germinal centre" EXACT []
is_a: MP:0002359 ! abnormal spleen germinal center morphology

[Term]
id: MP:0008475
name: intermingled spleen red and white pulp
def: "no clear demarcation of the spleen red and white pulp tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "intermingled splenic red and white pulp" EXACT []
is_a: MP:0002356 ! abnormal spleen red pulp morphology
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0008476
name: increased spleen red pulp amount
def: "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased splenic red pulp" EXACT []
is_a: MP:0002356 ! abnormal spleen red pulp morphology

[Term]
id: MP:0008477
name: decreased spleen red pulp amount
def: "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased splenic red pulp" EXACT []
synonym: "reduced spleen red pulp amount" EXACT []
is_a: MP:0002356 ! abnormal spleen red pulp morphology

[Term]
id: MP:0008478
name: increased spleen white pulp amount
def: "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased splenic white pulp amount" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0008479
name: decreased spleen white pulp amount
def: "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased splenic white pulp amount" EXACT []
synonym: "reduced spleen white pulp amount" EXACT []
is_a: MP:0002357 ! abnormal spleen white pulp morphology

[Term]
id: MP:0008480
name: absent eye pigmentation
def: "absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis" [https://orcid.org/0000-0003-3691-0324]
synonym: "albino eye" EXACT []
is_a: MP:0001324 ! abnormal eye pigmentation

[Term]
id: MP:0008481
name: increased spleen germinal center number
def: "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "increased spleen follicle center number" EXACT []
synonym: "increased spleen follicle centre number" EXACT []
synonym: "increased spleen GC number" EXACT []
synonym: "increased spleen germinal centre number" EXACT []
synonym: "increased splenic germinal center number" EXACT []
synonym: "increased splenic germinal centre number" EXACT []
is_a: MP:0002359 ! abnormal spleen germinal center morphology

[Term]
id: MP:0008482
name: decreased spleen germinal center number
def: "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "decreased spleen follicle center number" EXACT []
synonym: "decreased spleen follicle centre number" EXACT []
synonym: "decreased spleen GC number" EXACT []
synonym: "decreased spleen germinal centre number" EXACT []
synonym: "decreased splenic germinal center number" EXACT []
synonym: "decreased splenic germinal centre number" EXACT []
synonym: "reduced spleen follicle center number" EXACT []
synonym: "reduced spleen follicle centre number" EXACT []
synonym: "reduced spleen GC number" EXACT []
synonym: "reduced spleen germinal center number" EXACT []
synonym: "reduced spleen germinal centre number" EXACT []
is_a: MP:0002359 ! abnormal spleen germinal center morphology

[Term]
id: MP:0008483
name: increased spleen germinal center size
def: "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "increased spleen follicle center size" EXACT []
synonym: "increased spleen follicle centre size" EXACT []
synonym: "increased spleen GC size" EXACT []
synonym: "increased spleen germinal centre size" EXACT []
synonym: "increased splenic germinal center size" EXACT []
synonym: "increased splenic germinal centre size" EXACT []
is_a: MP:0002359 ! abnormal spleen germinal center morphology

[Term]
id: MP:0008484
name: decreased spleen germinal center size
def: "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "decreased spleen follicle center size" EXACT []
synonym: "decreased spleen follicle centre size" EXACT []
synonym: "decreased spleen GC size" EXACT []
synonym: "decreased splenic germinal center size" EXACT []
synonym: "decreased splenic germinal centre size" EXACT []
synonym: "reduced spleen follicle center size" EXACT []
synonym: "reduced spleen follicle centre size" EXACT []
synonym: "reduced spleen GC size" EXACT []
synonym: "reduced spleen germinal center size" EXACT []
synonym: "reduced spleen germinal centre size" EXACT []
is_a: MP:0002359 ! abnormal spleen germinal center morphology

[Term]
id: MP:0008485
name: increased muscle spindle number
def: "greater number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343]
synonym: "increased Kuhne spindle number" EXACT []
synonym: "increased neuromuscular spindle number" EXACT []
is_a: MP:0004069 ! abnormal muscle spindle morphology

[Term]
id: MP:0008486
name: decreased muscle spindle number
def: "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343]
synonym: "decreased Kuhne spindle number" EXACT []
synonym: "decreased neuromuscular spindle number" EXACT []
synonym: "reduced Kuhne spindle number" EXACT []
synonym: "reduced muscle spindle number" EXACT []
is_a: MP:0004069 ! abnormal muscle spindle morphology

[Term]
id: MP:0008487
name: abnormal mesonephros morphology
def: "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
comment: The mesonephros is the permanent kidney in fish and amphibians, but atrophies in reptiles, birds, and mammals.
synonym: "abnormal mesonephric tubules" NARROW []
synonym: "abnormal middle kidney" EXACT []
synonym: "abnormal primitive kidney" EXACT []
synonym: "abnormal Wolffian body morphology" EXACT []
synonym: "abnormal Wolffian tubules" NARROW []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0008488
name: abnormal semicircular canal ampulla morphology
def: "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8]
synonym: "abnormal membranous ampullae of the semicircular ducts" EXACT []
is_a: MP:0002428 ! abnormal semicircular canal morphology

[Term]
id: MP:0008489
name: slow postnatal weight gain
def: "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [https://orcid.org/0000-0003-3691-0324]
synonym: "postnatal slow weight gain" EXACT []
synonym: "reduced body weight gain" EXACT []
is_a: MP:0001262 ! decreased body weight
is_a: MP:0001732 ! postnatal growth retardation

[Term]
id: MP:0008490
name: enlarged dorsal root ganglion
def: "increased size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
synonym: "enlarged dorsal root ganglia" EXACT []
synonym: "enlarged DRG" EXACT []
synonym: "enlarged spinal ganglion" RELATED []
synonym: "increased dorsal root ganglion size" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0008491
name: dorsal root ganglion hyperplasia
def: "increase in the number of normal cells in normal arrangement in the dorsal root ganglion, typically resulting in increased size" [MESH:A08.340.390.340]
synonym: "dorsal root ganglia hyperplasia" EXACT []
synonym: "DRG hyperplasia" EXACT []
synonym: "hyperplastic dorsal root ganglion" EXACT []
synonym: "spinal ganglion hyperplasia" EXACT []
is_a: MP:0008490 ! enlarged dorsal root ganglion

[Term]
id: MP:0008492
name: dorsal root ganglion degeneration
def: "retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0008493
name: alpha-synuclein inclusion body
def: "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson's disease" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0008494
name: absence of all nails
def: "absence of all of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000579 ! abnormal nail morphology

[Term]
id: MP:0008495
name: decreased IgG1 level
def: "less than normal immunoglobulin class G1 level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased serum level of immunoglobulin G1" NARROW []
synonym: "reduced IgG1 level" EXACT []
is_a: MP:0001805 ! decreased IgG level
is_a: MP:0020175 ! abnormal IgG1 level

[Term]
id: MP:0008496
name: decreased IgG2a level
def: "less than normal immunoglobulin class G2a level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased serum level of immunoglobulin G2a" NARROW []
synonym: "reduced IgG2a level" EXACT []
is_a: MP:0013804 ! decreased IgG2 level
is_a: MP:0020176 ! abnormal IgG2a level

[Term]
id: MP:0008497
name: decreased IgG2b level
def: "less than normal immunoglobulin class G2b level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased serum level of immunoglobulin G2b" NARROW []
synonym: "reduced IgG2b level" EXACT []
is_a: MP:0013804 ! decreased IgG2 level
is_a: MP:0020177 ! abnormal IgG2b level

[Term]
id: MP:0008498
name: decreased IgG3 level
def: "less than normal immunoglobulin class G3 level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased serum level of immunoglobulin G3" NARROW []
synonym: "reduced IgG3 level" EXACT []
is_a: MP:0001805 ! decreased IgG level
is_a: MP:0020179 ! abnormal IgG3 level

[Term]
id: MP:0008499
name: increased IgG1 level
def: "greater than normal immunoglobulin class G1 level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased serum level of immunoglobulin G1" NARROW []
is_a: MP:0002493 ! increased IgG level
is_a: MP:0020175 ! abnormal IgG1 level

[Term]
id: MP:0008500
name: increased IgG2a level
def: "greater than normal immunoglobulin class G2a level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased serum level of immunoglobulin G2a" NARROW []
is_a: MP:0013803 ! increased IgG2 level
is_a: MP:0020176 ! abnormal IgG2a level

[Term]
id: MP:0008501
name: increased IgG2b level
def: "greater than normal immunoglobulin class G2b level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased serum level of immunoglobulin G2b" NARROW []
is_a: MP:0013803 ! increased IgG2 level
is_a: MP:0020177 ! abnormal IgG2b level

[Term]
id: MP:0008502
name: increased IgG3 level
def: "greater than normal immunoglobulin class G3 level" [https://orcid.org/0000-0003-1980-3228]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased serum level of immunoglobulin G3" NARROW []
is_a: MP:0002493 ! increased IgG level
is_a: MP:0020179 ! abnormal IgG3 level

[Term]
id: MP:0008503
name: abnormal spinal cord grey matter morphology
def: "any structural anomaly of the ridge-shaped grey matter of the spinal cord that extends longitudinally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "abnormal spinal cord gray columns morphology" EXACT []
synonym: "abnormal spinal cord gray matter morphology" EXACT []
synonym: "abnormal spinal cord grey columns morphology" EXACT []
synonym: "abnormal spinal cord mantle layer morphology" RELATED []
xref: MA:0000002
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0008504
name: abnormal adrenal chromaffin cell morphology
def: "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal phaeochromocyte" EXACT []
is_a: MP:0008289 ! abnormal adrenal medulla morphology
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology

[Term]
id: MP:0008505
name: absent adrenal chromaffin cells
def: "absence of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent phaeochromocyte" EXACT []
is_a: MP:0008504 ! abnormal adrenal chromaffin cell morphology

[Term]
id: MP:0008506
name: abnormal noradrenergic chromaffin cell morphology
def: "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for norepinephrine secretion" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008504 ! abnormal adrenal chromaffin cell morphology

[Term]
id: MP:0008507
name: thin retina ganglion layer
def: "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "thin retinal ganglion layer" EXACT []
is_a: MP:0005241 ! abnormal retina ganglion layer morphology

[Term]
id: MP:0008508
name: thick retina ganglion layer
def: "increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick retinal ganglion layer" EXACT []
is_a: MP:0005241 ! abnormal retina ganglion layer morphology

[Term]
id: MP:0008509
name: disorganized retina ganglion layer
def: "derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised retina ganglion layer" EXACT []
is_a: MP:0005241 ! abnormal retina ganglion layer morphology

[Term]
id: MP:0008510
name: absent retina ganglion layer
def: "absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent retinal ganglion layer" EXACT []
is_a: MP:0005241 ! abnormal retina ganglion layer morphology

[Term]
id: MP:0008511
name: thin retina inner nuclear layer
def: "reduced thickness of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased retina inner nuclear layer thickness" EXACT []
synonym: "decreased retinal INL thickness" EXACT []
synonym: "decreased retinal inner nuclear layer thickness" EXACT []
synonym: "reduced retina inner nuclear layer thickness" EXACT []
synonym: "reduced retinal inner nuclear layer thickness" EXACT []
synonym: "thin retinal inner nuclear layer" EXACT []
is_a: MP:0011996 ! abnormal retina inner nuclear layer thickness

[Term]
id: MP:0008512
name: disorganized retina inner nuclear layer
def: "derangement of the normal pattern of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0009-0005-7755-8314]
synonym: "disorganised retinal INL" EXACT []
synonym: "disorganized retinal inner nuclear layer" EXACT []
is_a: MP:0003733 ! abnormal retina inner nuclear layer morphology

[Term]
id: MP:0008513
name: thin retina inner plexiform layer
def: "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased retina inner plexiform layer thickness" EXACT []
synonym: "decreased retinal inner plexiform layer thickness" EXACT []
synonym: "reduced retina inner plexiform layer thickness" EXACT []
synonym: "reduced retinal inner plexiform layer thickness" EXACT []
synonym: "thin retina IPL" EXACT []
synonym: "thin retinal inner plexiform layer" EXACT []
synonym: "thin retinal IPL" EXACT []
is_a: MP:0003734 ! abnormal retina inner plexiform layer morphology

[Term]
id: MP:0008514
name: absent retina inner plexiform layer
def: "absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [https://orcid.org/0009-0005-7755-8314]
synonym: "absent retina IPL" EXACT []
synonym: "absent retinal inner plexiform layer" EXACT []
synonym: "absent retinal IPL" EXACT []
is_a: MP:0003734 ! abnormal retina inner plexiform layer morphology

[Term]
id: MP:0008515
name: thin retina outer nuclear layer
def: "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased retina ONL thickness" EXACT []
synonym: "decreased retina outer nuclear layer thickness" EXACT []
synonym: "decreased retinal ONL thickness" EXACT []
synonym: "decreased retinal outer nuclear layer thickness" EXACT []
synonym: "reduced retina ONL thickness" EXACT []
synonym: "reduced retina outer nuclear layer thickness" EXACT []
synonym: "reduced retinal ONL thickness" EXACT []
synonym: "reduced retinal outer nuclear layer thickness" EXACT []
synonym: "thin retinal outer nuclear layer" EXACT []
is_a: MP:0011997 ! abnormal retina outer nuclear layer thickness

[Term]
id: MP:0008516
name: disorganized retina outer nuclear layer
def: "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0009-0005-7755-8314]
synonym: "disorganised retina ONL" EXACT []
synonym: "disorganized retinal ONL" EXACT []
synonym: "disorganized retinal outer nuclear layer" EXACT []
is_a: MP:0003731 ! abnormal retina outer nuclear layer morphology

[Term]
id: MP:0008517
name: thick retina outer nuclear layer
def: "increased thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0009-0005-7755-8314]
synonym: "increased retina outer nuclear layer thickness" EXACT []
synonym: "increased retinal outer nuclear layer thickness" EXACT []
synonym: "thick retinal outer nuclear layer" EXACT []
is_a: MP:0011997 ! abnormal retina outer nuclear layer thickness

[Term]
id: MP:0008518
name: retina outer nuclear layer degeneration
def: "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0009-0005-7755-8314]
synonym: "retina ONL degeneration" EXACT []
synonym: "retinal ONL degeneration" EXACT []
synonym: "retinal outer nuclear layer degeneration" EXACT []
is_a: MP:0003731 ! abnormal retina outer nuclear layer morphology

[Term]
id: MP:0008519
name: thin retina outer plexiform layer
def: "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased retina OPL thickness" EXACT []
synonym: "decreased retina outer plexiform layer thickness" EXACT []
synonym: "decreased retinal OPL thickness" EXACT []
synonym: "decreased retinal outer plexiform layer thickness" EXACT []
synonym: "reduced retina OPL thickness" EXACT []
synonym: "reduced retinal OPL thickness" EXACT []
synonym: "thin retina OPL" EXACT []
synonym: "thin retinal OPL" EXACT []
synonym: "thin retinal outer plexiform layer" EXACT []
is_a: MP:0003732 ! abnormal retina outer plexiform layer morphology

[Term]
id: MP:0008520
name: disorganized retina outer plexiform layer
def: "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [https://orcid.org/0009-0005-7755-8314]
synonym: "disorganised retina OPL" EXACT []
synonym: "disorganized retinal OPL" EXACT []
synonym: "disorganized retinal outer plexiform layer" EXACT []
is_a: MP:0003732 ! abnormal retina outer plexiform layer morphology

[Term]
id: MP:0008521
name: abnormal Bowman membrane morphology
def: "any structural anomaly of the layer of acellular matrix that lies beneath the corneal epithelium and above the corneal stroma, consists of randomly arranged collagen fibers in a condensed bed of intercellular substance, and provides stability and strength to the cornea" [MESH:A09.371.060.217.113]
synonym: "abnormal Bowman's membrane" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0008522
name: abnormal lymph node germinal center morphology
def: "any structural anomaly of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells" [PMID:11905817]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "abnormal lymph node germinal centre morphology" EXACT []
is_a: MP:0002346 ! abnormal lymph node secondary follicle morphology

[Term]
id: MP:0008523
name: absent lymph node germinal center
def: "absence of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells" [PMID:11905817]
comment: Germinal centers are often identified by the binding of peanut agglutinin (PNA).
synonym: "absent lymph node germinal centre" EXACT []
is_a: MP:0008522 ! abnormal lymph node germinal center morphology

[Term]
id: MP:0008524
name: increased plasmacytoid dendritic cell number
def: "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [https://orcid.org/0000-0003-3691-0324, PMID:15596797]
synonym: "increased DC2 cell number" EXACT []
synonym: "increased lymphoid dendritic cell number" EXACT []
synonym: "increased PDC cell number" EXACT []
synonym: "increased pDC cell number" EXACT []
synonym: "increased plasmacytoid monocytes cell number" EXACT []
synonym: "increased plasmacytoid T cell number" EXACT []
synonym: "increased T-associated plasma cells cell number" EXACT []
is_a: MP:0000218 ! increased leukocyte cell number
is_a: MP:0008123 ! abnormal plasmacytoid dendritic cell number
is_a: MP:0008126 ! increased dendritic cell number

[Term]
id: MP:0008525
name: decreased cranium height
alt_id: MP:0000442
def: "decrease in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skull height" RELATED []
synonym: "longitudinally short skull" RELATED []
synonym: "reduced cranium height" EXACT []
is_a: MP:0010031 ! abnormal cranium size

[Term]
id: MP:0008526
name: decreased cranium width
def: "having a decreased side-to-side, or lateral distance of the cranium" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skull width" RELATED []
synonym: "reduced cranium width" EXACT []
synonym: "reduced skull width" RELATED []
is_a: MP:0010031 ! abnormal cranium size

[Term]
id: MP:0008527
name: embryonic lethality at implantation
def: "death due to failure of implantation (Mus: E4.5)" [MGI:llw2]
is_a: MP:0013292 ! embryonic lethality prior to organogenesis

[Term]
id: MP:0008528
name: polycystic kidney
def: "presence of multiple fluid-filled cysts in one or both kidneys" [MGI:llw2]
subset: CvDC_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "multicystic kidney dysplasia" NARROW []
synonym: "multiple renal cysts" EXACT []
synonym: "polycystic kidney disease" RELATED []
synonym: "polycystic kidneys" NARROW []
xref: Fyler:4508
is_a: MP:0003675 ! kidney cyst

[Term]
id: MP:0008529
name: enlarged optic nerve
def: "increased size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased optic nerve size" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0008530
name: abnormal rostral-caudal patterning of the somites
def: "anomaly in the developmental pattern of the somites along the axis that runs from the rostral to the caudal region of the body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001688 ! abnormal somite development
is_a: MP:0005221 ! abnormal rostral-caudal axis patterning

[Term]
id: MP:0008531
name: increased chemical nociceptive threshold
def: "a greater than average concentration at which chemically induced pain sensation is first detectable" [https://orcid.org/0000-0003-3691-0324]
synonym: "chemical hypoalgesia" EXACT []
is_a: MP:0002735 ! abnormal chemical nociception
is_a: MP:0003043 ! hypoalgesia

[Term]
id: MP:0008532
name: decreased chemical nociceptive threshold
def: "a lower than average concentration at which chemically induced pain sensation is first detectable" [https://orcid.org/0000-0003-3691-0324]
synonym: "chemical hyperalgesia" RELATED []
synonym: "reduced chemical nociceptive threshold" EXACT []
is_a: MP:0002735 ! abnormal chemical nociception
is_a: MP:0005407 ! hyperalgesia

[Term]
id: MP:0008533
name: abnormal anterior visceral endoderm morphology
def: "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
synonym: "abnormal AVE" EXACT []
is_a: MP:0011186 ! abnormal visceral endoderm morphology

[Term]
id: MP:0008534
name: enlarged fourth ventricle
def: "increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [https://orcid.org/0000-0003-3691-0324, MESH:A08.186.211.276.500]
synonym: "enlarged 4th ventricle" EXACT []
synonym: "enlarged IVth ventricle" EXACT []
synonym: "enlarged rhombencephalic ventricle" EXACT []
synonym: "enlarged ventricle of rhombencephalon" EXACT []
synonym: "enlarged ventriculus quartus" EXACT []
synonym: "increased fourth ventricle size" EXACT []
is_a: MP:0000828 ! abnormal fourth ventricle morphology
is_a: MP:0011380 ! enlarged brain ventricles

[Term]
id: MP:0008535
name: enlarged lateral ventricles
def: "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [https://orcid.org/0000-0003-3691-0324, MESH:A08.186.211.276.650]
subset: IMPC
subset: Sanger_Terms
synonym: "increased lateral ventricle size" EXACT []
is_a: MP:0000823 ! abnormal lateral ventricle morphology
is_a: MP:0011380 ! enlarged brain ventricles

[Term]
id: MP:0008536
name: enlarged third ventricle
def: "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [https://orcid.org/0000-0003-3691-0324, MESH:A08.186.211.276.840]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged 3rd ventricle" EXACT []
synonym: "enlarged ventriculus tertius" EXACT []
synonym: "increased third ventricle size" EXACT []
synonym: "increased ventriculus tertius size" RELATED []
is_a: MP:0000826 ! abnormal third ventricle morphology
is_a: MP:0011380 ! enlarged brain ventricles

[Term]
id: MP:0008537
name: increased susceptibility to induced colitis
def: "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to induced colitis" EXACT []
is_a: MP:0002816 ! colitis
is_a: MP:0013296 ! abnormal susceptibility to induced colitis

[Term]
id: MP:0008538
name: decreased zigzag hair amount
def: "reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
synonym: "decreased amount of zigzag hair" EXACT []
synonym: "reduced amount of zigzag hair" EXACT []
is_a: MP:0000402 ! abnormal zigzag hair morphology

[Term]
id: MP:0008539
name: decreased susceptibility to induced colitis
def: "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased resistance to induced colitis" EXACT []
synonym: "reduced susceptibility to induced colitis" EXACT []
is_a: MP:0001876 ! decreased inflammatory response
is_a: MP:0013296 ! abnormal susceptibility to induced colitis

[Term]
id: MP:0008540
name: abnormal cerebral hemisphere morphology
def: "any structural anomaly of the largest part of the brain; the cerebrum is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
synonym: "abnormal cerebral hemispheres morphology" EXACT []
synonym: "abnormal cerebrum morphology" EXACT []
synonym: "cerebrum dysplasia" NARROW []
is_a: MP:0000787 ! abnormal telencephalon morphology

[Term]
id: MP:0008541
name: leukostasis
def: "abnormal intravascular leukocyte aggregation and clumping most commonly seen in the brain and lungs of organisms with leukemia, often with an excess of leukocytes in the blood" [MESH:C15.378.553.560]
synonym: "leucostasis" EXACT []
is_a: MP:0002442 ! abnormal leukocyte physiology

[Term]
id: MP:0008542
name: enlarged cervical lymph nodes
def: "increased size of the lymph nodes found near the neck and shoulders" [https://orcid.org/0000-0003-3691-0324]
synonym: "cervical lymphoadenopathy" RELATED []
synonym: "increased cervical lymph node size" EXACT []
is_a: MP:0002351 ! abnormal cervical lymph node morphology

[Term]
id: MP:0008543
name: atrial fibrillation
def: "asynchronous contraction or quivering of individual cardiac muscle fibers in the atria" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006109 ! fibrillation

[Term]
id: MP:0008544
name: impaired olfaction
def: "reduced ability to detect odors" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyposmia" EXACT []
synonym: "partial anosmia" EXACT []
is_a: MP:0001984 ! abnormal olfaction

[Term]
id: MP:0008545
name: absent sperm flagellum
def: "absence of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
synonym: "absent sperm flagella" EXACT []
synonym: "absent sperm tail" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0008546
name: abnormal vesicle-mediated transport
def: "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
synonym: "abnormal vesicle trafficking" EXACT []
synonym: "abnormal vesicle transport" EXACT []
synonym: "abnormal vesicular trafficking" EXACT []
synonym: "abnormal vesicular transport" EXACT []
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0008547
name: abnormal neocortex morphology
def: "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8, MESH:A08.186.211.730.885.213.420]
synonym: "abnormal homotypic cortex morphology" EXACT []
synonym: "abnormal homotypical cortex morphology" EXACT []
synonym: "abnormal isocortex morphology" EXACT []
synonym: "abnormal neopallium morphology" EXACT []
synonym: "abnormal nonolfactory cortex morphology" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology

[Term]
id: MP:0008548
name: abnormal circulating interferon level
def: "anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
synonym: "abnormal circulating IFN level" EXACT []
is_a: MP:0008750 ! abnormal interferon level
is_a: MP:0010210 ! abnormal circulating cytokine level

[Term]
id: MP:0008549
name: abnormal circulating interferon-alpha level
def: "anomaly in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "abnormal circulating alpha-IFN level" EXACT []
synonym: "abnormal circulating alpha-Interferon level" EXACT []
synonym: "abnormal circulating IFN-alpha level" EXACT []
is_a: MP:0008548 ! abnormal circulating interferon level

[Term]
id: MP:0008550
name: abnormal circulating interferon-beta level
def: "anomaly in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "abnormal circulating beta-IFN level" EXACT []
synonym: "abnormal circulating beta-interferon level" EXACT []
synonym: "abnormal circulating IFN-beta level" EXACT []
is_a: MP:0008548 ! abnormal circulating interferon level

[Term]
id: MP:0008551
name: abnormal circulating interferon-gamma level
def: "anomaly in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "abnormal circulating gamma-IFN level" EXACT []
synonym: "abnormal circulating gamma-interferon level" EXACT []
synonym: "abnormal circulating IFN-gamma level" EXACT []
synonym: "abnormal circulating interferon type II level" EXACT []
is_a: MP:0008548 ! abnormal circulating interferon level

[Term]
id: MP:0008552
name: abnormal circulating tumor necrosis factor level
def: "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "abnormal circulating cachectin level" EXACT []
synonym: "abnormal circulating TNF level" RELATED []
synonym: "abnormal circulating TNFA level" EXACT []
synonym: "abnormal circulating tumor necrosis factor alpha level" EXACT []
synonym: "abnormal circulating tumour necrosis factor alpha level" EXACT []
synonym: "abnormal circulating tumour necrosis factor level" EXACT []
is_a: MP:0008752 ! abnormal tumor necrosis factor level
is_a: MP:0010210 ! abnormal circulating cytokine level

[Term]
id: MP:0008553
name: increased circulating tumor necrosis factor level
def: "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "increased circulating cachectin level" EXACT []
synonym: "increased circulating TNF level" RELATED []
synonym: "increased circulating TNFA level" EXACT []
synonym: "increased circulating tumor necrosis factor alpha level" EXACT []
synonym: "increased circulating tumour necrosis factor alpha level" EXACT []
synonym: "increased circulating tumour necrosis factor level" EXACT []
is_a: MP:0008552 ! abnormal circulating tumor necrosis factor level
is_a: MP:0014493 ! increased circulating cytokine level

[Term]
id: MP:0008554
name: decreased circulating tumor necrosis factor level
def: "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "decreased circulating cachectin level" EXACT []
synonym: "decreased circulating TNF level" EXACT []
synonym: "decreased circulating TNFA level" EXACT []
synonym: "decreased circulating tumor necrosis factor alpha level" EXACT []
synonym: "decreased circulating tumour necrosis factor alpha level" EXACT []
synonym: "decreased circulating tumour necrosis factor level" EXACT []
synonym: "reduced circulating cachectin level" EXACT []
synonym: "reduced circulating TNF level" EXACT []
synonym: "reduced circulating TNFA level" EXACT []
synonym: "reduced circulating tumor necrosis factor alpha level" EXACT []
synonym: "reduced circulating tumor necrosis factor level" EXACT []
synonym: "reduced circulating tumour necrosis factor alpha level" EXACT []
synonym: "reduced circulating tumour necrosis factor level" EXACT []
is_a: MP:0008552 ! abnormal circulating tumor necrosis factor level
is_a: MP:0014494 ! decreased circulating cytokine level

[Term]
id: MP:0008555
name: abnormal interferon secretion
def: "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
synonym: "abnormal IFN secretion" EXACT []
is_a: MP:0003009 ! abnormal cytokine secretion

[Term]
id: MP:0008556
name: abnormal tumor necrosis factor secretion
def: "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "abnormal cachectin secretion" EXACT []
synonym: "abnormal TNF secretion" EXACT []
synonym: "abnormal TNFA secretion" EXACT []
synonym: "abnormal tumor necrosis factor alpha secretion" EXACT []
synonym: "abnormal tumour necrosis factor alpha secretion" EXACT []
synonym: "abnormal tumour necrosis factor secretion" EXACT []
is_a: MP:0003009 ! abnormal cytokine secretion

[Term]
id: MP:0008557
name: abnormal interferon-alpha secretion
def: "anomaly in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "abnormal alpha-IFN secretion" EXACT []
synonym: "abnormal alpha-Interferon secretion" EXACT []
synonym: "abnormal IFN-alpha secretion" EXACT []
is_a: MP:0008555 ! abnormal interferon secretion

[Term]
id: MP:0008558
name: abnormal interferon-beta secretion
def: "anomaly in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "abnormal beta-IFN secretion" EXACT []
synonym: "abnormal beta-interferon secretion" EXACT []
synonym: "abnormal IFN-beta secretion" EXACT []
is_a: MP:0008555 ! abnormal interferon secretion

[Term]
id: MP:0008559
name: abnormal interferon-gamma secretion
def: "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "abnormal gamma-IFN secretion" EXACT []
synonym: "abnormal gamma-interferon secretion" EXACT []
synonym: "abnormal IFN-gamma secretion" EXACT []
synonym: "abnormal interferon type II secretion" EXACT []
is_a: MP:0008555 ! abnormal interferon secretion

[Term]
id: MP:0008560
name: increased tumor necrosis factor secretion
def: "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "increased cachectin secretion" EXACT []
synonym: "increased TNF secretion" EXACT []
synonym: "increased TNFA secretion" EXACT []
synonym: "increased tumor necrosis factor alpha secretion" EXACT []
synonym: "increased tumour necrosis factor alpha secretion" EXACT []
synonym: "increased tumour necrosis factor secretion" EXACT []
is_a: MP:0008556 ! abnormal tumor necrosis factor secretion

[Term]
id: MP:0008561
name: decreased tumor necrosis factor secretion
def: "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7, MESH:D12.644.276.374.500.800]
synonym: "decreased cachectin secretion" EXACT []
synonym: "decreased TNF secretion" EXACT []
synonym: "decreased TNFA secretion" EXACT []
synonym: "decreased tumor necrosis factor alpha secretion" EXACT []
synonym: "decreased tumour necrosis factor alpha secretion" EXACT []
synonym: "decreased tumour necrosis factor secretion" EXACT []
synonym: "reduced cachectin secretion" EXACT []
synonym: "reduced TNF secretion" EXACT []
synonym: "reduced TNFA secretion" EXACT []
synonym: "reduced tumor necrosis factor alpha secretion" EXACT []
synonym: "reduced tumour necrosis factor alpha secretion" EXACT []
is_a: MP:0008556 ! abnormal tumor necrosis factor secretion

[Term]
id: MP:0008562
name: increased interferon-alpha secretion
def: "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "increased alpha-IFN secretion" EXACT []
synonym: "increased alpha-Interferon secretion" EXACT []
synonym: "increased IFN-alpha secretion" EXACT []
is_a: MP:0008557 ! abnormal interferon-alpha secretion

[Term]
id: MP:0008563
name: decreased interferon-alpha secretion
def: "decrease in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "decreased alpha-IFN secretion" EXACT []
synonym: "decreased alpha-Interferon secretion" EXACT []
synonym: "decreased IFN-alpha secretion" EXACT []
synonym: "reduced alpha-IFN secretion" EXACT []
synonym: "reduced alpha-Interferon secretion" EXACT []
synonym: "reduced IFN-alpha secretion" EXACT []
is_a: MP:0008557 ! abnormal interferon-alpha secretion

[Term]
id: MP:0008564
name: increased interferon-beta secretion
def: "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "increased beta-IFN secretion" EXACT []
synonym: "increased beta-interferon secretion" EXACT []
synonym: "increased IFN-beta secretion" EXACT []
is_a: MP:0008558 ! abnormal interferon-beta secretion

[Term]
id: MP:0008565
name: decreased interferon-beta secretion
def: "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "decreased beta-IFN secretion" EXACT []
synonym: "decreased beta-interferon secretion" EXACT []
synonym: "decreased IFN-beta secretion" EXACT []
synonym: "reduced beta-IFN secretion" EXACT []
synonym: "reduced beta-interferon secretion" EXACT []
synonym: "reduced IFN-beta secretion" EXACT []
is_a: MP:0008558 ! abnormal interferon-beta secretion

[Term]
id: MP:0008566
name: increased interferon-gamma secretion
def: "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "increased gamma-IFN secretion" EXACT []
synonym: "increased gamma-interferon secretion" EXACT []
synonym: "increased IFN-gamma secretion" EXACT []
synonym: "increased interferon type II secretion" EXACT []
is_a: MP:0008559 ! abnormal interferon-gamma secretion

[Term]
id: MP:0008567
name: decreased interferon-gamma secretion
def: "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "decreased gamma-IFN secretion" EXACT []
synonym: "decreased gamma-interferon secretion" EXACT []
synonym: "decreased IFN-gamma secretion" EXACT []
synonym: "decreased interferon type II secretion" EXACT []
synonym: "reduced gamma-IFN secretion" EXACT []
synonym: "reduced gamma-interferon secretion" EXACT []
synonym: "reduced IFN-gamma secretion" EXACT []
synonym: "reduced interferon type II secretion" EXACT []
is_a: MP:0008559 ! abnormal interferon-gamma secretion

[Term]
id: MP:0008568
name: abnormal interleukin secretion
def: "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
is_a: MP:0003009 ! abnormal cytokine secretion

[Term]
id: MP:0008569
name: lethality at weaning
def: "premature death at weaning age, often due to the inability to make the transition to solid food" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "weanling lethality" EXACT []
is_a: MP:0010769 ! abnormal survival

[Term]
id: MP:0008570
name: lipidosis
def: "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2]
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0008571
name: abnormal synaptic bouton morphology
def: "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
synonym: "abnormal axon terminal morphology" NARROW []
synonym: "abnormal pre-synaptic terminal morphology" NARROW []
synonym: "abnormal presynaptic terminal morphology" NARROW []
is_a: MP:0005404 ! abnormal axon morphology

[Term]
id: MP:0008572
name: abnormal Purkinje cell dendrite morphology
def: "any structural anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal Purkinje cell dendrites" EXACT []
synonym: "abnormal Purkinje cell dendritic arbor" EXACT []
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0008143 ! abnormal dendrite morphology

[Term]
id: MP:0008573
name: increased circulating interferon-alpha level
def: "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "increased circulating alpha-IFN level" EXACT []
synonym: "increased circulating alpha-Interferon level" EXACT []
synonym: "increased circulating IFN-alpha level" EXACT []
is_a: MP:0008549 ! abnormal circulating interferon-alpha level
is_a: MP:0014435 ! increased interferon level

[Term]
id: MP:0008574
name: decreased circulating interferon-alpha level
def: "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
synonym: "decreased circulating alpha-IFN level" EXACT []
synonym: "decreased circulating alpha-Interferon level" EXACT []
synonym: "decreased circulating IFN-alpha level" EXACT []
synonym: "reduced circulating alpha-IFN level" EXACT []
synonym: "reduced circulating alpha-Interferon level" EXACT []
synonym: "reduced circulating IFN-alpha level" EXACT []
is_a: MP:0008549 ! abnormal circulating interferon-alpha level
is_a: MP:0014436 ! decreased interferon level

[Term]
id: MP:0008575
name: increased circulating interferon-beta level
def: "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "increased circulating beta-IFN level" EXACT []
synonym: "increased circulating beta-interferon level" EXACT []
synonym: "increased circulating IFN-beta level" EXACT []
is_a: MP:0008550 ! abnormal circulating interferon-beta level
is_a: MP:0014435 ! increased interferon level

[Term]
id: MP:0008576
name: decreased circulating interferon-beta level
def: "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
synonym: "decreased circulating beta-IFN level" EXACT []
synonym: "decreased circulating beta-interferon level" EXACT []
synonym: "decreased circulating IFN-beta level" EXACT []
synonym: "reduced circulating beta-IFN level" EXACT []
synonym: "reduced circulating beta-interferon level" EXACT []
synonym: "reduced circulating IFN-beta level" EXACT []
is_a: MP:0008550 ! abnormal circulating interferon-beta level
is_a: MP:0014436 ! decreased interferon level

[Term]
id: MP:0008577
name: increased circulating interferon-gamma level
def: "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "increased circulating gamma-IFN level" EXACT []
synonym: "increased circulating gamma-interferon level" EXACT []
synonym: "increased circulating IFN-gamma level" EXACT []
synonym: "increased circulating interferon type II level" EXACT []
is_a: MP:0008551 ! abnormal circulating interferon-gamma level
is_a: MP:0014435 ! increased interferon level

[Term]
id: MP:0008578
name: decreased circulating interferon-gamma level
def: "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
synonym: "decreased circulating gamma-IFN level" EXACT []
synonym: "decreased circulating gamma-interferon level" EXACT []
synonym: "decreased circulating IFN-gamma level" EXACT []
synonym: "decreased circulating interferon type II level" EXACT []
synonym: "reduced circulating gamma-IFN level" EXACT []
synonym: "reduced circulating gamma-interferon level" EXACT []
synonym: "reduced circulating IFN-gamma level" EXACT []
synonym: "reduced circulating interferon type II level" EXACT []
is_a: MP:0008551 ! abnormal circulating interferon-gamma level
is_a: MP:0014436 ! decreased interferon level

[Term]
id: MP:0008579
name: abnormal Purkinje cell differentiation
def: "atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343]
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0008580
name: photoreceptor inner segment degeneration
def: "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008581
name: disorganized photoreceptor inner segment
def: "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised photoreceptor inner segment" EXACT []
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008582
name: short photoreceptor inner segment
def: "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased photoreceptor inner segment length" EXACT []
synonym: "reduced photoreceptor inner segment length" EXACT []
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008583
name: absent photoreceptor inner segment
def: "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology

[Term]
id: MP:0008584
name: photoreceptor outer segment degeneration
def: "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology

[Term]
id: MP:0008585
name: absent photoreceptor outer segment
def: "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0020815 ! abnormal photoreceptor outer segment number

[Term]
id: MP:0008586
name: disorganized photoreceptor outer segment
def: "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised photoreceptor outer segment" EXACT []
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology

[Term]
id: MP:0008587
name: short photoreceptor outer segment
def: "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased photoreceptor outer segment length" EXACT []
is_a: MP:0020811 ! abnormal photoreceptor outer segment size

[Term]
id: MP:0008588
name: abnormal circulating interleukin level
def: "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
synonym: "abnormal circulating IL level" EXACT []
is_a: MP:0008751 ! abnormal interleukin level
is_a: MP:0010210 ! abnormal circulating cytokine level

[Term]
id: MP:0008589
name: abnormal circulating interleukin-1 level
def: "anomaly in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "abnormal circulating epidermal cell derived thymocyte-activating factor level" EXACT []
synonym: "abnormal circulating IL-1 level" EXACT []
synonym: "abnormal circulating interleukin I level" EXACT []
synonym: "abnormal circulating lymphocyte-activating factor level" EXACT []
synonym: "abnormal circulating macrophage cell factor level" EXACT []
synonym: "abnormal circulating T helper factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008590
name: abnormal circulating interleukin-10 level
def: "anomaly in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "abnormal circulating CSIF-10 level" EXACT []
synonym: "abnormal circulating cytokine synthesis inhibitory factor level" EXACT []
synonym: "abnormal circulating IL-10 level" EXACT []
synonym: "abnormal circulating IL10 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008591
name: increased circulating interleukin-1 level
def: "increase in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "increased circulating epidermal cell derived thymocyte-activating factor level" EXACT []
synonym: "increased circulating IL-1 level" EXACT []
synonym: "increased circulating interleukin I level" EXACT []
synonym: "increased circulating lymphocyte-activating factor level" EXACT []
synonym: "increased circulating macrophage cell factor level" EXACT []
synonym: "increased circulating T helper factor level" EXACT []
is_a: MP:0008589 ! abnormal circulating interleukin-1 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008592
name: decreased circulating interleukin-1 level
def: "reduction in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "decreased circulating epidermal cell derived thymocyte-activating factor level" EXACT []
synonym: "decreased circulating IL-1 level" EXACT []
synonym: "decreased circulating interleukin I level" EXACT []
synonym: "decreased circulating lymphocyte-activating factor level" EXACT []
synonym: "decreased circulating macrophage cell factor level" EXACT []
synonym: "decreased circulating T helper factor level" EXACT []
synonym: "reduced circulating epidermal cell derived thymocyte-activating factor level" EXACT []
synonym: "reduced circulating IL-1 level" EXACT []
synonym: "reduced circulating interleukin I level" EXACT []
synonym: "reduced circulating lymphocyte-activating factor level" EXACT []
synonym: "reduced circulating macrophage cell factor level" EXACT []
synonym: "reduced circulating T helper factor level" EXACT []
is_a: MP:0008589 ! abnormal circulating interleukin-1 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008593
name: increased circulating interleukin-10 level
def: "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "increased circulating CSIF-10 level" EXACT []
synonym: "increased circulating cytokine synthesis inhibitory factor level" EXACT []
synonym: "increased circulating IL-10 level" EXACT []
synonym: "increased circulating IL10 level" EXACT []
is_a: MP:0008590 ! abnormal circulating interleukin-10 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008594
name: decreased circulating interleukin-10 level
def: "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "decreased circulating CSIF-10 level" EXACT []
synonym: "decreased circulating cytokine synthesis inhibitory factor level" EXACT []
synonym: "decreased circulating IL-10 level" EXACT []
synonym: "decreased circulating IL10 level" EXACT []
synonym: "reduced circulating CSIF-10 level" EXACT []
synonym: "reduced circulating cytokine synthesis inhibitory factor level" EXACT []
synonym: "reduced circulating IL-10 level" EXACT []
synonym: "reduced circulating IL10 level" EXACT []
is_a: MP:0008590 ! abnormal circulating interleukin-10 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008595
name: abnormal circulating interleukin-6 level
def: "anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "abnormal circulating B cell stimulatory factor-2 level" EXACT []
synonym: "abnormal circulating B-cell differentiation factor level" EXACT []
synonym: "abnormal circulating B-cell differentiation factor-2 level" EXACT []
synonym: "abnormal circulating B-cell stimulatory factor 2 level" EXACT []
synonym: "abnormal circulating B-cell stimulatory factor-2 level" EXACT []
synonym: "abnormal circulating BSF-2 level" EXACT []
synonym: "abnormal circulating hepatocyte-stimulating factor level" EXACT []
synonym: "abnormal circulating hybridoma growth factor level" EXACT []
synonym: "abnormal circulating IFN-beta 2 level" EXACT []
synonym: "abnormal circulating IL-6 level" EXACT []
synonym: "abnormal circulating IL6 level" EXACT []
synonym: "abnormal circulating MGI-2 level" EXACT []
synonym: "abnormal circulating myeloid differentiation-inducing protein level" EXACT []
synonym: "abnormal circulating plasmacytoma growth factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008596
name: increased circulating interleukin-6 level
def: "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "increased circulating B cell stimulatory factor-2 level" EXACT []
synonym: "increased circulating B-cell differentiation factor level" EXACT []
synonym: "increased circulating B-cell differentiation factor-2 level" EXACT []
synonym: "increased circulating B-cell stimulatory factor 2 level" EXACT []
synonym: "increased circulating B-cell stimulatory factor-2 level" EXACT []
synonym: "increased circulating BSF-2 level" EXACT []
synonym: "increased circulating hepatocyte-stimulating factor level" EXACT []
synonym: "increased circulating hybridoma growth factor level" EXACT []
synonym: "increased circulating IFN-beta 2 level" EXACT []
synonym: "increased circulating IL-6 level" EXACT []
synonym: "increased circulating IL6 level" EXACT []
synonym: "increased circulating MGI-2 level" EXACT []
synonym: "increased circulating myeloid differentiation-inducing protein level" EXACT []
synonym: "increased circulating plasmacytoma growth factor level" EXACT []
is_a: MP:0008595 ! abnormal circulating interleukin-6 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008597
name: decreased circulating interleukin-6 level
def: "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "decreased circulating B cell stimulatory factor-2 level" EXACT []
synonym: "decreased circulating B-cell differentiation factor level" EXACT []
synonym: "decreased circulating B-cell differentiation factor-2 level" EXACT []
synonym: "decreased circulating B-cell stimulatory factor 2 level" EXACT []
synonym: "decreased circulating B-cell stimulatory factor-2 level" EXACT []
synonym: "decreased circulating BSF-2 level" EXACT []
synonym: "decreased circulating hepatocyte-stimulating factor level" EXACT []
synonym: "decreased circulating hybridoma growth factor level" EXACT []
synonym: "decreased circulating IFN-beta 2 level" EXACT []
synonym: "decreased circulating IL-6 level" EXACT []
synonym: "decreased circulating IL6 level" EXACT []
synonym: "decreased circulating MGI-2 level" EXACT []
synonym: "decreased circulating myeloid differentiation-inducing protein level" EXACT []
synonym: "decreased circulating plasmacytoma growth factor level" EXACT []
synonym: "reduced circulating B cell stimulatory factor-2 level" EXACT []
synonym: "reduced circulating B-cell differentiation factor level" EXACT []
synonym: "reduced circulating B-cell differentiation factor-2 level" EXACT []
synonym: "reduced circulating B-cell stimulatory factor 2 level" EXACT []
synonym: "reduced circulating B-cell stimulatory factor-2 level" EXACT []
synonym: "reduced circulating BSF-2 level" EXACT []
synonym: "reduced circulating hepatocyte-stimulating factor level" EXACT []
synonym: "reduced circulating hybridoma growth factor level" EXACT []
synonym: "reduced circulating IFN-beta 2 level" EXACT []
synonym: "reduced circulating IL-6 level" EXACT []
synonym: "reduced circulating IL6 level" EXACT []
synonym: "reduced circulating MGI-2 level" EXACT []
synonym: "reduced circulating myeloid differentiation-inducing protein level" EXACT []
synonym: "reduced circulating plasmacytoma growth factor level" EXACT []
is_a: MP:0008595 ! abnormal circulating interleukin-6 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008598
name: abnormal circulating interleukin-2 level
def: "anomaly in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "abnormal circulating IL-2 level" EXACT []
synonym: "abnormal circulating IL2 level" EXACT []
synonym: "abnormal circulating interleukin II level" EXACT []
synonym: "abnormal circulating interleukine 2 level" EXACT []
synonym: "abnormal circulating lymphocyte mitogenic factor level" EXACT []
synonym: "abnormal circulating Ro-23-6019 level" EXACT []
synonym: "abnormal circulating Ro-236019 level" EXACT []
synonym: "abnormal circulating RU 49637 level" EXACT []
synonym: "abnormal circulating RU-49637 level" EXACT []
synonym: "abnormal circulating T-cell growth factor level" EXACT []
synonym: "abnormal circulating T-cell stimulating factor level" EXACT []
synonym: "abnormal circulating TCGF level" EXACT []
synonym: "abnormal circulating thymocyte stimulating factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008599
name: increased circulating interleukin-2 level
def: "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "increased circulating IL-2 level" EXACT []
synonym: "increased circulating IL2 level" EXACT []
synonym: "increased circulating interleukin II level" EXACT []
synonym: "increased circulating interleukine 2 level" EXACT []
synonym: "increased circulating lymphocyte mitogenic factor level" EXACT []
synonym: "increased circulating Ro-23-6019 level" EXACT []
synonym: "increased circulating Ro-236019 level" EXACT []
synonym: "increased circulating RU 49637 level" EXACT []
synonym: "increased circulating RU-49637 level" EXACT []
synonym: "increased circulating T-cell growth factor level" EXACT []
synonym: "increased circulating T-cell stimulating factor level" EXACT []
synonym: "increased circulating TCGF level" EXACT []
synonym: "increased circulating thymocyte stimulating factor level" EXACT []
is_a: MP:0008598 ! abnormal circulating interleukin-2 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008600
name: decreased circulating interleukin-2 level
def: "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "decreased circulating IL-2 level" EXACT []
synonym: "decreased circulating IL2 level" EXACT []
synonym: "decreased circulating interleukin II level" EXACT []
synonym: "decreased circulating interleukine 2 level" EXACT []
synonym: "decreased circulating lymphocyte mitogenic factor level" EXACT []
synonym: "decreased circulating Ro-23-6019 level" EXACT []
synonym: "decreased circulating Ro-236019 level" EXACT []
synonym: "decreased circulating RU 49637 level" EXACT []
synonym: "decreased circulating RU-49637 level" EXACT []
synonym: "decreased circulating T-cell growth factor level" EXACT []
synonym: "decreased circulating T-cell stimulating factor level" EXACT []
synonym: "decreased circulating TCGF level" EXACT []
synonym: "decreased circulating thymocyte stimulating factor level" EXACT []
synonym: "reduced circulating IL-2 level" EXACT []
synonym: "reduced circulating IL2 level" EXACT []
synonym: "reduced circulating interleukin II level" EXACT []
synonym: "reduced circulating interleukine 2 level" EXACT []
synonym: "reduced circulating lymphocyte mitogenic factor level" EXACT []
synonym: "reduced circulating Ro-23-6019 level" EXACT []
synonym: "reduced circulating Ro-236019 level" EXACT []
synonym: "reduced circulating RU 49637 level" EXACT []
synonym: "reduced circulating RU-49637 level" EXACT []
synonym: "reduced circulating T-cell growth factor level" EXACT []
synonym: "reduced circulating T-cell stimulating factor level" EXACT []
synonym: "reduced circulating TCGF level" EXACT []
synonym: "reduced circulating thymocyte stimulating factor level" EXACT []
is_a: MP:0008598 ! abnormal circulating interleukin-2 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008601
name: abnormal circulating interleukin-4 level
def: "anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "abnormal circulating B cell stimulatory factor-1 level" EXACT []
synonym: "abnormal circulating B-cell growth factor-1 level" EXACT []
synonym: "abnormal circulating B-cell growth factor-I level" EXACT []
synonym: "abnormal circulating B-cell proliferating factor level" EXACT []
synonym: "abnormal circulating B-cell stimulating factor-1 level" EXACT []
synonym: "abnormal circulating B-cell stimulatory factor 1 level" EXACT []
synonym: "abnormal circulating B-cell stimulatory factor-1 level" EXACT []
synonym: "abnormal circulating BCGF-1 level" EXACT []
synonym: "abnormal circulating Binetrakin level" EXACT []
synonym: "abnormal circulating BSF-1 level" EXACT []
synonym: "abnormal circulating IL-4 level" EXACT []
synonym: "abnormal circulating IL4 level" EXACT []
synonym: "abnormal circulating mast cell growth factor-2 level" EXACT []
synonym: "abnormal circulating MCGF-2 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008602
name: increased circulating interleukin-4 level
def: "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "increased circulating B cell stimulatory factor-1 level" EXACT []
synonym: "increased circulating B-cell growth factor-1 level" EXACT []
synonym: "increased circulating B-cell growth factor-I level" EXACT []
synonym: "increased circulating B-cell proliferating factor level" EXACT []
synonym: "increased circulating B-cell stimulating factor-1 level" EXACT []
synonym: "increased circulating B-cell stimulatory factor 1 level" EXACT []
synonym: "increased circulating B-cell stimulatory factor-1 level" EXACT []
synonym: "increased circulating BCGF-1 level" EXACT []
synonym: "increased circulating Binetrakin level" EXACT []
synonym: "increased circulating BSF-1 level" EXACT []
synonym: "increased circulating IL-4 level" EXACT []
synonym: "increased circulating IL4 level" EXACT []
synonym: "increased circulating mast cell growth factor-2 level" EXACT []
synonym: "increased circulating MCGF-2 level" EXACT []
is_a: MP:0008601 ! abnormal circulating interleukin-4 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008603
name: decreased circulating interleukin-4 level
def: "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "decreased circulating B cell stimulatory factor-1 level" EXACT []
synonym: "decreased circulating B-cell growth factor-1 level" EXACT []
synonym: "decreased circulating B-cell growth factor-I level" EXACT []
synonym: "decreased circulating B-cell proliferating factor level" EXACT []
synonym: "decreased circulating B-cell stimulating factor-1 level" EXACT []
synonym: "decreased circulating B-cell stimulatory factor 1 level" EXACT []
synonym: "decreased circulating B-cell stimulatory factor-1 level" EXACT []
synonym: "decreased circulating BCGF-1 level" EXACT []
synonym: "decreased circulating Binetrakin level" EXACT []
synonym: "decreased circulating BSF-1 level" EXACT []
synonym: "decreased circulating IL-4 level" EXACT []
synonym: "decreased circulating IL4 level" EXACT []
synonym: "decreased circulating mast cell growth factor-2 level" EXACT []
synonym: "decreased circulating MCGF-2 level" EXACT []
synonym: "reduced circulating B cell stimulatory factor-1 level" EXACT []
synonym: "reduced circulating B-cell growth factor-1 level" EXACT []
synonym: "reduced circulating B-cell growth factor-I level" EXACT []
synonym: "reduced circulating B-cell proliferating factor level" EXACT []
synonym: "reduced circulating B-cell stimulating factor-1 level" EXACT []
synonym: "reduced circulating B-cell stimulatory factor 1 level" EXACT []
synonym: "reduced circulating B-cell stimulatory factor-1 level" EXACT []
synonym: "reduced circulating BCGF-1 level" EXACT []
synonym: "reduced circulating Binetrakin level" EXACT []
synonym: "reduced circulating BSF-1 level" EXACT []
synonym: "reduced circulating IL-4 level" EXACT []
synonym: "reduced circulating IL4 level" EXACT []
synonym: "reduced circulating mast cell growth factor-2 level" EXACT []
synonym: "reduced circulating MCGF-2 level" EXACT []
is_a: MP:0008601 ! abnormal circulating interleukin-4 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008604
name: abnormal circulating interleukin-7 level
def: "anomaly in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "abnormal circulating IL-7 level" EXACT []
synonym: "abnormal circulating IL7 level" EXACT []
synonym: "abnormal circulating lymphopoietin-1 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008605
name: increased circulating interleukin-7 level
def: "increase in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "increased circulating IL-7 level" EXACT []
synonym: "increased circulating IL7 level" EXACT []
synonym: "increased circulating lymphopoietin-1 level" EXACT []
is_a: MP:0008604 ! abnormal circulating interleukin-7 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008606
name: decreased circulating interleukin-7 level
def: "reduction in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "decreased circulating IL-7 level" EXACT []
synonym: "decreased circulating IL7 level" EXACT []
synonym: "decreased circulating lymphopoietin-1 level" EXACT []
synonym: "reduced circulating IL-7 level" EXACT []
synonym: "reduced circulating IL7 level" EXACT []
synonym: "reduced circulating lymphopoietin-1 level" EXACT []
is_a: MP:0008604 ! abnormal circulating interleukin-7 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008607
name: abnormal circulating interleukin-13 level
def: "anomaly in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "abnormal circulating IL-13 level" EXACT []
synonym: "abnormal circulating IL13 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008608
name: increased circulating interleukin-13 level
def: "increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "increased circulating IL-13 level" EXACT []
synonym: "increased circulating IL13 level" EXACT []
is_a: MP:0008607 ! abnormal circulating interleukin-13 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008609
name: decreased circulating interleukin-13 level
def: "reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "decreased circulating IL-13 level" EXACT []
synonym: "decreased circulating IL13 level" EXACT []
synonym: "reduced circulating IL-13 level" EXACT []
synonym: "reduced circulating IL13 level" EXACT []
is_a: MP:0008607 ! abnormal circulating interleukin-13 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008610
name: abnormal circulating interleukin-15 level
def: "anomaly in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "abnormal circulating IL-15 level" EXACT []
synonym: "abnormal circulating IL15 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008611
name: increased circulating interleukin-15 level
def: "increase in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "increased circulating IL-15 level" EXACT []
synonym: "increased circulating IL15 level" EXACT []
is_a: MP:0008610 ! abnormal circulating interleukin-15 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008612
name: decreased circulating interleukin-15 level
def: "reduction in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "decreased circulating IL-15 level" EXACT []
synonym: "decreased circulating IL15 level" EXACT []
synonym: "reduced circulating IL-15 level" EXACT []
synonym: "reduced circulating IL15 level" EXACT []
is_a: MP:0008610 ! abnormal circulating interleukin-15 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008613
name: abnormal circulating interleukin-17 level
def: "anomaly in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "abnormal circulating CTLA-8 level" NARROW []
synonym: "abnormal circulating CTLA8 level" NARROW []
synonym: "abnormal circulating cytokine CX2 level" NARROW []
synonym: "abnormal circulating cytotoxic T lymphocyte-associated antigen 8 level" NARROW []
synonym: "abnormal circulating IL-17 level" EXACT []
synonym: "abnormal circulating IL17 level" EXACT []
synonym: "abnormal circulating ML-1 level" NARROW []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008614
name: increased circulating interleukin-17 level
def: "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "increased circulating CTLA-8 level" NARROW []
synonym: "increased circulating CTLA8 level" NARROW []
synonym: "increased circulating cytokine CX2 level" NARROW []
synonym: "increased circulating cytotoxic T lymphocyte-associated antigen 8 level" NARROW []
synonym: "increased circulating IL-17 level" EXACT []
synonym: "increased circulating IL17 level" EXACT []
synonym: "increased circulating ML-1 level" NARROW []
is_a: MP:0008613 ! abnormal circulating interleukin-17 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008615
name: decreased circulating interleukin-17 level
def: "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "decreased circulating CTLA-8 level" NARROW []
synonym: "decreased circulating CTLA8 level" NARROW []
synonym: "decreased circulating cytokine CX2 level" NARROW []
synonym: "decreased circulating cytotoxic T lymphocyte-associated antigen 8 level" NARROW []
synonym: "decreased circulating IL-17 level" EXACT []
synonym: "decreased circulating IL17 level" EXACT []
synonym: "decreased circulating ML-1 level" NARROW []
synonym: "reduced circulating CTLA-8 level" NARROW []
synonym: "reduced circulating CTLA8 level" NARROW []
synonym: "reduced circulating cytokine CX2 level" NARROW []
synonym: "reduced circulating cytotoxic T lymphocyte-associated antigen 8 level" NARROW []
synonym: "reduced circulating IL-17 level" EXACT []
synonym: "reduced circulating IL17 level" EXACT []
synonym: "reduced circulating ML-1 level" NARROW []
is_a: MP:0008613 ! abnormal circulating interleukin-17 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008616
name: abnormal circulating interleukin-12 level
def: "anomaly in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a (19kDa) chain.
synonym: "abnormal circulating cytotoxic lymphocyte maturation factor level" EXACT []
synonym: "abnormal circulating IL-12 level" EXACT []
synonym: "abnormal circulating IL-12 p70 level" EXACT []
synonym: "abnormal circulating IL12 level" EXACT []
synonym: "abnormal circulating interleukin-12 p70 level" EXACT []
synonym: "abnormal circulating natural killer cell stimulatory factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008617
name: increased circulating interleukin-12 level
def: "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
synonym: "increased circulating cytotoxic lymphocyte maturation factor level" EXACT []
synonym: "increased circulating IL-12 level" EXACT []
synonym: "increased circulating IL-12 p70 level" EXACT []
synonym: "increased circulating IL12 level" EXACT []
synonym: "increased circulating interleukin-12 p70 level" EXACT []
synonym: "increased circulating natural killer cell stimulatory factor level" EXACT []
is_a: MP:0008616 ! abnormal circulating interleukin-12 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008618
name: decreased circulating interleukin-12 level
def: "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
synonym: "decreased circulating cytotoxic lymphocyte maturation factor level" EXACT []
synonym: "decreased circulating IL-12 level" EXACT []
synonym: "decreased circulating IL-12 p70 level" EXACT []
synonym: "decreased circulating IL12 level" EXACT []
synonym: "decreased circulating interleukin-12 p70 level" EXACT []
synonym: "decreased circulating natural killer cell stimulatory factor level" EXACT []
synonym: "reduced circulating cytotoxic lymphocyte maturation factor level" EXACT []
synonym: "reduced circulating IL-12 level" EXACT []
synonym: "reduced circulating IL-12 p70 level" EXACT []
synonym: "reduced circulating IL12 level" EXACT []
synonym: "reduced circulating interleukin-12 p70 level" EXACT []
synonym: "reduced circulating natural killer cell stimulatory factor level" EXACT []
is_a: MP:0008616 ! abnormal circulating interleukin-12 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008619
name: abnormal circulating interleukin-23 level
def: "anomaly in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "abnormal circulating IL-23 level" EXACT []
synonym: "abnormal circulating IL23 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008620
name: increased circulating interleukin-23 level
def: "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "increased circulating IL-23 level" EXACT []
synonym: "increased circulating IL23 level" EXACT []
is_a: MP:0008619 ! abnormal circulating interleukin-23 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008621
name: decreased circulating interleukin-23 level
def: "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "decreased circulating IL-23 level" EXACT []
synonym: "decreased circulating IL23 level" EXACT []
synonym: "reduced circulating IL-23 level" EXACT []
synonym: "reduced circulating IL23 level" EXACT []
is_a: MP:0008619 ! abnormal circulating interleukin-23 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008622
name: abnormal circulating interleukin-3 level
def: "anomaly in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "abnormal circulating colony-stimulating factor 2 alpha level" EXACT []
synonym: "abnormal circulating eosinophil-mast cell growth-factor level" EXACT []
synonym: "abnormal circulating erythrocyte burst-promoting factor level" EXACT []
synonym: "abnormal circulating haematopoietin-2 level" EXACT []
synonym: "abnormal circulating hematopoietin-2 level" EXACT []
synonym: "abnormal circulating IL-3 level" EXACT []
synonym: "abnormal circulating IL3 level" EXACT []
synonym: "abnormal circulating mast-cell colony-stimulating factor level" EXACT []
synonym: "abnormal circulating multipotential colony-stimulating factor level" EXACT []
synonym: "abnormal circulating P-cell stimulating factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008623
name: increased circulating interleukin-3 level
def: "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "increased circulating colony-stimulating factor 2 alpha level" EXACT []
synonym: "increased circulating eosinophil-mast cell growth-factor level" EXACT []
synonym: "increased circulating erythrocyte burst-promoting factor level" EXACT []
synonym: "increased circulating haematopoietin-2 level" EXACT []
synonym: "increased circulating hematopoietin-2 level" EXACT []
synonym: "increased circulating IL-3 level" EXACT []
synonym: "increased circulating IL3 level" EXACT []
synonym: "increased circulating mast-cell colony-stimulating factor level" EXACT []
synonym: "increased circulating multipotential colony-stimulating factor level" EXACT []
synonym: "increased circulating P-cell stimulating factor level" EXACT []
is_a: MP:0008622 ! abnormal circulating interleukin-3 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008624
name: decreased circulating interleukin-3 level
def: "reduction in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "decreased circulating colony-stimulating factor 2 alpha level" EXACT []
synonym: "decreased circulating eosinophil-mast cell growth-factor level" EXACT []
synonym: "decreased circulating erythrocyte burst-promoting factor level" EXACT []
synonym: "decreased circulating haematopoietin-2 level" EXACT []
synonym: "decreased circulating hematopoietin-2 level" EXACT []
synonym: "decreased circulating IL-3 level" EXACT []
synonym: "decreased circulating IL3 level" EXACT []
synonym: "decreased circulating mast-cell colony-stimulating factor level" EXACT []
synonym: "decreased circulating multipotential colony-stimulating factor level" EXACT []
synonym: "decreased circulating P-cell stimulating factor level" EXACT []
synonym: "reduced circulating colony-stimulating factor 2 alpha level" EXACT []
synonym: "reduced circulating eosinophil-mast cell growth-factor level" EXACT []
synonym: "reduced circulating erythrocyte burst-promoting factor level" EXACT []
synonym: "reduced circulating haematopoietin-2 level" EXACT []
synonym: "reduced circulating hematopoietin-2 level" EXACT []
synonym: "reduced circulating IL-3 level" EXACT []
synonym: "reduced circulating IL3 level" EXACT []
synonym: "reduced circulating mast-cell colony-stimulating factor level" EXACT []
synonym: "reduced circulating multipotential colony-stimulating factor level" EXACT []
synonym: "reduced circulating P-cell stimulating factor level" EXACT []
is_a: MP:0008622 ! abnormal circulating interleukin-3 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008625
name: abnormal circulating interleukin-5 level
def: "anomaly in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "abnormal circulating B-cell growth factor-II level" EXACT []
synonym: "abnormal circulating BCGF-II level" EXACT []
synonym: "abnormal circulating eosinophil differentiation factor level" EXACT []
synonym: "abnormal circulating IL-5 level" EXACT []
synonym: "abnormal circulating IL5 level" EXACT []
synonym: "abnormal circulating T-cell replacing factor level" EXACT []
synonym: "abnormal circulating T-cell-replacing factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008626
name: increased circulating interleukin-5 level
def: "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "increased circulating B-cell growth factor-II level" EXACT []
synonym: "increased circulating BCGF-II level" EXACT []
synonym: "increased circulating eosinophil differentiation factor level" EXACT []
synonym: "increased circulating IL-5 level" EXACT []
synonym: "increased circulating IL5 level" EXACT []
synonym: "increased circulating T-cell replacing factor level" EXACT []
synonym: "increased circulating T-cell-replacing factor level" EXACT []
is_a: MP:0008625 ! abnormal circulating interleukin-5 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008627
name: decreased circulating interleukin-5 level
def: "reduction in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "decreased circulating B-cell growth factor-II level" EXACT []
synonym: "decreased circulating BCGF-II level" EXACT []
synonym: "decreased circulating eosinophil differentiation factor level" EXACT []
synonym: "decreased circulating IL-5 level" EXACT []
synonym: "decreased circulating IL5 level" EXACT []
synonym: "decreased circulating T-cell replacing factor level" EXACT []
synonym: "decreased circulating T-cell-replacing factor level" EXACT []
synonym: "reduced circulating B-cell growth factor-II level" EXACT []
synonym: "reduced circulating BCGF-II level" EXACT []
synonym: "reduced circulating eosinophil differentiation factor level" EXACT []
synonym: "reduced circulating IL-5 level" EXACT []
synonym: "reduced circulating IL5 level" EXACT []
synonym: "reduced circulating T-cell replacing factor level" EXACT []
synonym: "reduced circulating T-cell-replacing factor level" EXACT []
is_a: MP:0008625 ! abnormal circulating interleukin-5 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008628
name: abnormal circulating interleukin-9 level
def: "anomaly in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "abnormal circulating IL-9 level" EXACT []
synonym: "abnormal circulating IL9 level" EXACT []
synonym: "abnormal circulating P40 T-Cell Growth Factor level" EXACT []
synonym: "abnormal circulating T-Cell Growth Factor P40 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008629
name: increased circulating interleukin-9 level
def: "increase in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "increased circulating IL-9 level" EXACT []
synonym: "increased circulating IL9 level" EXACT []
synonym: "increased circulating P40 T-Cell Growth Factor level" EXACT []
synonym: "increased circulating T-Cell Growth Factor P40 level" EXACT []
is_a: MP:0008628 ! abnormal circulating interleukin-9 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008630
name: decreased circulating interleukin-9 level
def: "reduction in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "decreased circulating IL-9 level" EXACT []
synonym: "decreased circulating IL9 level" EXACT []
synonym: "decreased circulating P40 T-Cell Growth Factor level" EXACT []
synonym: "decreased circulating T-Cell Growth Factor P40 level" EXACT []
synonym: "reduced circulating IL-9 level" EXACT []
synonym: "reduced circulating IL9 level" EXACT []
synonym: "reduced circulating P40 T-Cell Growth Factor level" EXACT []
synonym: "reduced circulating T-Cell Growth Factor P40 level" EXACT []
is_a: MP:0008628 ! abnormal circulating interleukin-9 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008631
name: abnormal circulating interleukin-16 level
def: "anomaly in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "abnormal circulating IL-16 level" EXACT []
synonym: "abnormal circulating IL16 level" EXACT []
synonym: "abnormal circulating LCF factor level" EXACT []
synonym: "abnormal circulating lymphocyte chemoattractant factor level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008632
name: increased circulating interleukin-16 level
def: "increase in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "increased circulating IL-16 level" EXACT []
synonym: "increased circulating IL16 level" EXACT []
synonym: "increased circulating LCF factor level" EXACT []
synonym: "increased circulating lymphocyte chemoattractant factor level" EXACT []
is_a: MP:0008631 ! abnormal circulating interleukin-16 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008633
name: decreased circulating interleukin-16 level
def: "reduction in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "decreased circulating IL-16 level" EXACT []
synonym: "decreased circulating IL16 level" EXACT []
synonym: "decreased circulating LCF factor level" EXACT []
synonym: "decreased circulating lymphocyte chemoattractant factor level" EXACT []
synonym: "reduced circulating IL-16 level" EXACT []
synonym: "reduced circulating IL16 level" EXACT []
synonym: "reduced circulating LCF factor level" EXACT []
synonym: "reduced circulating lymphocyte chemoattractant factor level" EXACT []
is_a: MP:0008631 ! abnormal circulating interleukin-16 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008634
name: abnormal circulating interleukin-18 level
def: "anomaly in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "abnormal circulating IFN-gamma inducing factor level" EXACT []
synonym: "abnormal circulating IL-18 level" EXACT []
synonym: "abnormal circulating IL18 level" EXACT []
synonym: "abnormal circulating interferon-gamma inducing factor" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008635
name: increased circulating interleukin-18 level
def: "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "increased circulating IFN-gamma inducing factor level" EXACT []
synonym: "increased circulating IL-18 level" EXACT []
synonym: "increased circulating IL18 level" EXACT []
synonym: "increased circulating interferon-gamma inducing factor" EXACT []
is_a: MP:0008634 ! abnormal circulating interleukin-18 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008636
name: decreased circulating interleukin-18 level
def: "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "decreased circulating IFN-gamma inducing factor level" EXACT []
synonym: "decreased circulating IL-18 level" EXACT []
synonym: "decreased circulating IL18 level" EXACT []
synonym: "decreased circulating interferon-gamma inducing factor" EXACT []
synonym: "reduced circulating IFN-gamma inducing factor level" EXACT []
synonym: "reduced circulating IL-18 level" EXACT []
synonym: "reduced circulating IL18 level" EXACT []
synonym: "reduced circulating interferon-gamma inducing factor" EXACT []
is_a: MP:0008634 ! abnormal circulating interleukin-18 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008637
name: abnormal circulating interleukin-1 alpha level
def: "anomaly in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "abnormal circulating haematopoietin-1 level" EXACT []
synonym: "abnormal circulating hematopoietin-1 level" EXACT []
synonym: "abnormal circulating IL-1a level" EXACT []
synonym: "abnormal circulating IL-1alpha level" EXACT []
synonym: "abnormal circulating IL1 alpha level" EXACT []
synonym: "abnormal circulating IL1a level" EXACT []
is_a: MP:0008589 ! abnormal circulating interleukin-1 level

[Term]
id: MP:0008638
name: increased circulating interleukin-1 alpha level
def: "increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "increased circulating haematopoietin-1 level" EXACT []
synonym: "increased circulating hematopoietin-1 level" EXACT []
synonym: "increased circulating IL-1a level" EXACT []
synonym: "increased circulating IL-1alpha level" EXACT []
synonym: "increased circulating IL1 alpha level" EXACT []
synonym: "increased circulating IL1a level" EXACT []
is_a: MP:0008591 ! increased circulating interleukin-1 level
is_a: MP:0008637 ! abnormal circulating interleukin-1 alpha level

[Term]
id: MP:0008639
name: decreased circulating interleukin-1 alpha level
def: "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "decreased circulating haematopoietin-1 level" EXACT []
synonym: "decreased circulating hematopoietin-1 level" EXACT []
synonym: "decreased circulating IL-1a level" EXACT []
synonym: "decreased circulating IL-1alpha level" EXACT []
synonym: "decreased circulating IL1 alpha level" EXACT []
synonym: "decreased circulating IL1a level" EXACT []
synonym: "reduced circulating haematopoietin-1 level" EXACT []
synonym: "reduced circulating hematopoietin-1 level" EXACT []
synonym: "reduced circulating IL-1a level" EXACT []
synonym: "reduced circulating IL-1alpha level" EXACT []
synonym: "reduced circulating IL1 alpha level" EXACT []
synonym: "reduced circulating IL1a level" EXACT []
is_a: MP:0008592 ! decreased circulating interleukin-1 level
is_a: MP:0008637 ! abnormal circulating interleukin-1 alpha level

[Term]
id: MP:0008640
name: abnormal circulating interleukin-1 beta level
def: "anomaly in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "abnormal circulating catabloin level" EXACT []
synonym: "abnormal circulating IL-1 beta level" EXACT []
synonym: "abnormal circulating IL-1b level" EXACT []
synonym: "abnormal circulating Il1b level" EXACT []
is_a: MP:0008589 ! abnormal circulating interleukin-1 level

[Term]
id: MP:0008641
name: increased circulating interleukin-1 beta level
def: "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "increased circulating catabloin level" EXACT []
synonym: "increased circulating IL-1 beta level" EXACT []
synonym: "increased circulating IL-1b level" EXACT []
synonym: "increased circulating Il1b level" EXACT []
is_a: MP:0008591 ! increased circulating interleukin-1 level
is_a: MP:0008640 ! abnormal circulating interleukin-1 beta level

[Term]
id: MP:0008642
name: decreased circulating interleukin-1 beta level
def: "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "decreased circulating catabloin level" EXACT []
synonym: "decreased circulating IL-1 beta level" EXACT []
synonym: "decreased circulating IL-1b level" EXACT []
synonym: "decreased circulating Il1b level" EXACT []
synonym: "reduced circulating catabloin level" EXACT []
synonym: "reduced circulating IL-1 beta level" EXACT []
synonym: "reduced circulating IL-1b level" EXACT []
synonym: "reduced circulating Il1b level" EXACT []
is_a: MP:0008592 ! decreased circulating interleukin-1 level
is_a: MP:0008640 ! abnormal circulating interleukin-1 beta level

[Term]
id: MP:0008643
name: abnormal circulating interleukin-12a level
def: "anomaly in the amount in the blood of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "abnormal circulating IL-12a level" EXACT []
synonym: "abnormal circulating IL-12p35 level" EXACT []
synonym: "abnormal circulating interleukin-12p35 level" EXACT []
is_a: MP:0008616 ! abnormal circulating interleukin-12 level

[Term]
id: MP:0008644
name: increased circulating interleukin-12a level
def: "increase in the amount in the blood of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "increased circulating IL-12a level" EXACT []
synonym: "increased circulating IL-12p35 level" EXACT []
synonym: "increased circulating interleukin-12p35 level" EXACT []
is_a: MP:0008617 ! increased circulating interleukin-12 level
is_a: MP:0008643 ! abnormal circulating interleukin-12a level

[Term]
id: MP:0008645
name: decreased circulating interleukin-12a level
def: "reduction in the amount in the blood of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "decreased circulating IL-12a level" EXACT []
synonym: "decreased circulating IL-12p35 level" EXACT []
synonym: "decreased circulating interleukin-12p35 level" EXACT []
synonym: "reduced circulating IL-12a level" EXACT []
synonym: "reduced circulating IL-12p35 level" EXACT []
synonym: "reduced circulating interleukin-12p35 level" EXACT []
is_a: MP:0008618 ! decreased circulating interleukin-12 level
is_a: MP:0008643 ! abnormal circulating interleukin-12a level

[Term]
id: MP:0008646
name: abnormal circulating interleukin-12b level
def: "anomaly in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "abnormal circulating IL-12b level" EXACT []
synonym: "abnormal circulating IL-12p40 level" EXACT []
synonym: "abnormal circulating IL-23b level" EXACT []
synonym: "abnormal circulating IL-23p40 level" EXACT []
synonym: "abnormal circulating interleukin-12 beta chain level" EXACT []
synonym: "abnormal circulating interleukin-12p40 level" EXACT []
synonym: "abnormal circulating interleukin-23 p40 level" EXACT []
synonym: "abnormal circulating interleukin-23b level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0008647
name: increased circulating interleukin-12b level
def: "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "increased circulating IL-12b level" EXACT []
synonym: "increased circulating IL-12p40 level" EXACT []
synonym: "increased circulating IL-23b level" EXACT []
synonym: "increased circulating IL-23p40 level" EXACT []
synonym: "increased circulating interleukin-12 beta chain level" EXACT []
synonym: "increased circulating interleukin-12p40 level" EXACT []
synonym: "increased circulating interleukin-23 p40 level" EXACT []
synonym: "increased circulating interleukin-23b level" EXACT []
is_a: MP:0008646 ! abnormal circulating interleukin-12b level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0008648
name: decreased circulating interleukin-12b level
def: "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "decreased circulating IL-12b level" EXACT []
synonym: "decreased circulating IL-12p40 level" EXACT []
synonym: "decreased circulating IL-23b level" EXACT []
synonym: "decreased circulating IL-23p40 level" EXACT []
synonym: "decreased circulating interleukin-12 beta chain level" EXACT []
synonym: "decreased circulating interleukin-12p40 level" EXACT []
synonym: "decreased circulating interleukin-23 p40 level" EXACT []
synonym: "decreased circulating interleukin-23b level" EXACT []
synonym: "reduced circulating IL-12b level" EXACT []
synonym: "reduced circulating IL-12p40 level" EXACT []
synonym: "reduced circulating IL-23b level" EXACT []
synonym: "reduced circulating IL-23p40 level" EXACT []
synonym: "reduced circulating interleukin-12 beta chain level" EXACT []
synonym: "reduced circulating interleukin-12p40 level" EXACT []
synonym: "reduced circulating interleukin-23 p40 level" EXACT []
synonym: "reduced circulating interleukin-23b level" EXACT []
is_a: MP:0008646 ! abnormal circulating interleukin-12b level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0008649
name: abnormal circulating interleukin-23a level
def: "anomaly in the amount in the blood of the p19 subunit of interleukin-23" [MESH:D12.644.276.374.465.759.500]
synonym: "abnormal circulating IL-23 alpha level" EXACT []
synonym: "abnormal circulating IL-23 p19 level" EXACT []
synonym: "abnormal circulating IL-23a level" EXACT []
synonym: "abnormal circulating IL-23p19 level" EXACT []
synonym: "abnormal circulating interleukin-23 alpha level" EXACT []
synonym: "abnormal circulating interleukin-23p19 level" EXACT []
is_a: MP:0008619 ! abnormal circulating interleukin-23 level

[Term]
id: MP:0008650
name: abnormal interleukin-1 secretion
def: "anomaly in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "abnormal epidermal cell derived thymocyte-activating factor secretion" EXACT []
synonym: "abnormal IL-1 secretion" EXACT []
synonym: "abnormal interleukin I secretion" EXACT []
synonym: "abnormal lymphocyte-activating factor secretion" EXACT []
synonym: "abnormal macrophage cell factor secretion" EXACT []
synonym: "abnormal T helper factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008651
name: increased interleukin-1 secretion
def: "increase in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "increased epidermal cell derived thymocyte-activating factor secretion" EXACT []
synonym: "increased IL-1 secretion" EXACT []
synonym: "increased interleukin I secretion" EXACT []
synonym: "increased lymphocyte-activating factor secretion" EXACT []
synonym: "increased macrophage cell factor secretion" EXACT []
synonym: "increased T helper factor secretion" EXACT []
is_a: MP:0008650 ! abnormal interleukin-1 secretion

[Term]
id: MP:0008652
name: decreased interleukin-1 secretion
def: "reduction in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
synonym: "decreased epidermal cell derived thymocyte-activating factor secretion" EXACT []
synonym: "decreased IL-1 secretion" EXACT []
synonym: "decreased interleukin I secretion" EXACT []
synonym: "decreased lymphocyte-activating factor secretion" EXACT []
synonym: "decreased macrophage cell factor secretion" EXACT []
synonym: "decreased T helper factor secretion" EXACT []
synonym: "reduced epidermal cell derived thymocyte-activating factor secretion" EXACT []
synonym: "reduced IL-1 secretion" EXACT []
synonym: "reduced interleukin I secretion" EXACT []
synonym: "reduced lymphocyte-activating factor secretion" EXACT []
synonym: "reduced macrophage cell factor secretion" EXACT []
synonym: "reduced T helper factor secretion" EXACT []
is_a: MP:0008650 ! abnormal interleukin-1 secretion

[Term]
id: MP:0008653
name: abnormal interleukin-1 alpha secretion
def: "anomaly in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "abnormal haematopoietin-1 secretion" EXACT []
synonym: "abnormal hematopoietin-1 secretion" EXACT []
synonym: "abnormal IL-1a secretion" EXACT []
synonym: "abnormal IL-1alpha secretion" EXACT []
synonym: "abnormal IL1 alpha secretion" EXACT []
synonym: "abnormal IL1a secretion" EXACT []
is_a: MP:0008650 ! abnormal interleukin-1 secretion

[Term]
id: MP:0008654
name: increased interleukin-1 alpha secretion
def: "increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "increased haematopoietin-1 secretion" EXACT []
synonym: "increased hematopoietin-1 secretion" EXACT []
synonym: "increased IL-1a secretion" EXACT []
synonym: "increased IL-1alpha secretion" EXACT []
synonym: "increased IL1 alpha secretion" EXACT []
synonym: "increased IL1a secretion" EXACT []
is_a: MP:0008653 ! abnormal interleukin-1 alpha secretion

[Term]
id: MP:0008655
name: decreased interleukin-1 alpha secretion
def: "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
synonym: "decreased haematopoietin-1 secretion" EXACT []
synonym: "decreased hematopoietin-1 secretion" EXACT []
synonym: "decreased IL-1a secretion" EXACT []
synonym: "decreased IL-1alpha secretion" EXACT []
synonym: "decreased IL1 alpha secretion" EXACT []
synonym: "decreased IL1a secretion" EXACT []
synonym: "reduced haematopoietin-1 secretion" EXACT []
synonym: "reduced hematopoietin-1 secretion" EXACT []
synonym: "reduced IL-1a secretion" EXACT []
synonym: "reduced IL-1alpha secretion" EXACT []
synonym: "reduced IL1 alpha secretion" EXACT []
synonym: "reduced IL1a secretion" EXACT []
is_a: MP:0008653 ! abnormal interleukin-1 alpha secretion

[Term]
id: MP:0008656
name: abnormal interleukin-1 beta secretion
def: "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "abnormal catabloin secretion" EXACT []
synonym: "abnormal IL-1 beta secretion" EXACT []
synonym: "abnormal IL-1b secretion" EXACT []
synonym: "abnormal Il1b secretion" EXACT []
is_a: MP:0008650 ! abnormal interleukin-1 secretion

[Term]
id: MP:0008657
name: increased interleukin-1 beta secretion
def: "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "increased catabloin secretion" EXACT []
synonym: "increased IL-1 beta secretion" EXACT []
synonym: "increased IL-1b secretion" EXACT []
synonym: "increased Il1b secretion" EXACT []
is_a: MP:0008656 ! abnormal interleukin-1 beta secretion

[Term]
id: MP:0008658
name: decreased interleukin-1 beta secretion
def: "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
synonym: "decreased catabloin secretion" EXACT []
synonym: "decreased IL-1 beta secretion" EXACT []
synonym: "decreased IL-1b secretion" EXACT []
synonym: "decreased Il1b secretion" EXACT []
synonym: "reduced catabloin secretion" EXACT []
synonym: "reduced IL-1 beta secretion" EXACT []
synonym: "reduced IL-1b secretion" EXACT []
synonym: "reduced Il1b secretion" EXACT []
is_a: MP:0008656 ! abnormal interleukin-1 beta secretion

[Term]
id: MP:0008659
name: abnormal interleukin-10 secretion
def: "anomaly in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "abnormal CSIF-10 secretion" EXACT []
synonym: "abnormal cytokine synthesis inhibitory factor secretion" EXACT []
synonym: "abnormal IL-10 secretion" EXACT []
synonym: "abnormal IL10 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008660
name: increased interleukin-10 secretion
def: "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "increased CSIF-10 secretion" EXACT []
synonym: "increased cytokine synthesis inhibitory factor secretion" EXACT []
synonym: "increased IL-10 secretion" EXACT []
synonym: "increased IL10 secretion" EXACT []
is_a: MP:0008659 ! abnormal interleukin-10 secretion

[Term]
id: MP:0008661
name: decreased interleukin-10 secretion
def: "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
synonym: "decreased CSIF-10 secretion" EXACT []
synonym: "decreased cytokine synthesis inhibitory factor secretion" EXACT []
synonym: "decreased IL-10 secretion" EXACT []
synonym: "decreased IL10 secretion" EXACT []
synonym: "reduced CSIF-10 secretion" EXACT []
synonym: "reduced cytokine synthesis inhibitory factor secretion" EXACT []
synonym: "reduced IL-10 secretion" EXACT []
synonym: "reduced IL10 secretion" EXACT []
is_a: MP:0008659 ! abnormal interleukin-10 secretion

[Term]
id: MP:0008662
name: abnormal interleukin-12 secretion
def: "anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
synonym: "abnormal cytotoxic lymphocyte maturation factor secretion" EXACT []
synonym: "abnormal IL-12 p70 secretion" EXACT []
synonym: "abnormal IL-12 secretion" EXACT []
synonym: "abnormal IL12 secretion" EXACT []
synonym: "abnormal interleukin-12 p70 secretion" EXACT []
synonym: "abnormal natural killer cell stimulatory factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008663
name: increased interleukin-12 secretion
def: "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
synonym: "increased cytotoxic lymphocyte maturation factor secretion" EXACT []
synonym: "increased IL-12 p70 secretion" EXACT []
synonym: "increased IL-12 secretion" EXACT []
synonym: "increased IL12 secretion" EXACT []
synonym: "increased interleukin-12 p70 secretion" EXACT []
synonym: "increased natural killer cell stimulatory factor secretion" EXACT []
is_a: MP:0008662 ! abnormal interleukin-12 secretion

[Term]
id: MP:0008664
name: decreased interleukin-12 secretion
def: "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
comment: Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa (IL-12b) and 35 kDa (IL-12a) subunits. The 40 kDa subunit (IL-12b) also is a component of interleukin-23 together with the IL-23a ( 19kDa) chain.
synonym: "decreased cytotoxic lymphocyte maturation factor secretion" EXACT []
synonym: "decreased IL-12 p70 secretion" EXACT []
synonym: "decreased IL-12 secretion" EXACT []
synonym: "decreased IL12 secretion" EXACT []
synonym: "decreased interleukin-12 p70 secretion" EXACT []
synonym: "decreased natural killer cell stimulatory factor secretion" EXACT []
synonym: "reduced cytotoxic lymphocyte maturation factor secretion" EXACT []
synonym: "reduced IL-12 p70 secretion" EXACT []
synonym: "reduced IL-12 secretion" EXACT []
synonym: "reduced IL12 secretion" EXACT []
synonym: "reduced interleukin-12 p70 secretion" EXACT []
synonym: "reduced natural killer cell stimulatory factor secretion" EXACT []
is_a: MP:0008662 ! abnormal interleukin-12 secretion

[Term]
id: MP:0008665
name: abnormal interleukin-12a secretion
def: "anomaly in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "abnormal IL-12a secretion" EXACT []
synonym: "abnormal IL-12p35 secretion" EXACT []
synonym: "abnormal interleukin-12p35 secretion" EXACT []
is_a: MP:0008662 ! abnormal interleukin-12 secretion

[Term]
id: MP:0008666
name: increased interleukin-12a secretion
def: "increase in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "increased IL-12a secretion" EXACT []
synonym: "increased IL-12p35 secretion" EXACT []
synonym: "increased interleukin-12p35 secretion" EXACT []
is_a: MP:0008665 ! abnormal interleukin-12a secretion

[Term]
id: MP:0008667
name: decreased interleukin-12a secretion
def: "reduction in the production or release of the p35 subunit of interleukin-12" [MESH:D12.644.276.374.465.512.249]
synonym: "decreased IL-12a secretion" EXACT []
synonym: "decreased IL-12p35 secretion" EXACT []
synonym: "decreased interleukin-12p35 secretion" EXACT []
synonym: "reduced IL-12a secretion" EXACT []
synonym: "reduced IL-12p35 secretion" EXACT []
synonym: "reduced interleukin-12p35 secretion" EXACT []
is_a: MP:0008665 ! abnormal interleukin-12a secretion

[Term]
id: MP:0008668
name: abnormal interleukin-12b secretion
def: "anomaly in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "abnormal IL-12b secretion" EXACT []
synonym: "abnormal IL-12p40 secretion" EXACT []
synonym: "abnormal IL-23b secretion" EXACT []
synonym: "abnormal IL-23p40 secretion" EXACT []
synonym: "abnormal interleukin-12 beta chain secretion" EXACT []
synonym: "abnormal interleukin-12p40 secretion" EXACT []
synonym: "abnormal interleukin-23 p40 secretion" EXACT []
synonym: "abnormal interleukin-23b secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008669
name: increased interleukin-12b secretion
def: "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "increased IL-12b secretion" EXACT []
synonym: "increased IL-12p40 secretion" EXACT []
synonym: "increased IL-23b secretion" EXACT []
synonym: "increased IL-23p40 secretion" EXACT []
synonym: "increased interleukin-12 beta chain secretion" EXACT []
synonym: "increased interleukin-12p40 secretion" EXACT []
synonym: "increased interleukin-23 p40 secretion" EXACT []
synonym: "increased interleukin-23b secretion" EXACT []
is_a: MP:0008668 ! abnormal interleukin-12b secretion

[Term]
id: MP:0008670
name: decreased interleukin-12b secretion
def: "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
synonym: "decreased IL-12b secretion" EXACT []
synonym: "decreased IL-12p40 secretion" EXACT []
synonym: "decreased IL-23b secretion" EXACT []
synonym: "decreased IL-23p40 secretion" EXACT []
synonym: "decreased interleukin-12 beta chain secretion" EXACT []
synonym: "decreased interleukin-12p40 secretion" EXACT []
synonym: "decreased interleukin-23 p40 secretion" EXACT []
synonym: "decreased interleukin-23b secretion" EXACT []
synonym: "reduced IL-12b secretion" EXACT []
synonym: "reduced IL-12p40 secretion" EXACT []
synonym: "reduced IL-23b secretion" EXACT []
synonym: "reduced IL-23p40 secretion" EXACT []
synonym: "reduced interleukin-12 beta chain secretion" EXACT []
synonym: "reduced interleukin-12p40 secretion" EXACT []
synonym: "reduced interleukin-23 p40 secretion" EXACT []
synonym: "reduced interleukin-23b secretion" EXACT []
is_a: MP:0008668 ! abnormal interleukin-12b secretion

[Term]
id: MP:0008671
name: abnormal interleukin-13 secretion
def: "anomaly in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "abnormal IL-13 secretion" EXACT []
synonym: "abnormal IL13 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008672
name: increased interleukin-13 secretion
def: "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "increased IL-13 secretion" EXACT []
synonym: "increased IL13 secretion" EXACT []
is_a: MP:0008671 ! abnormal interleukin-13 secretion

[Term]
id: MP:0008673
name: decreased interleukin-13 secretion
def: "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
synonym: "decreased IL-13 secretion" EXACT []
synonym: "decreased IL13 secretion" EXACT []
synonym: "reduced IL-13 secretion" EXACT []
synonym: "reduced IL13 secretion" EXACT []
is_a: MP:0008671 ! abnormal interleukin-13 secretion

[Term]
id: MP:0008674
name: abnormal interleukin-15 secretion
def: "anomaly in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "abnormal IL-15 secretion" EXACT []
synonym: "abnormal IL15 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008675
name: increased interleukin-15 secretion
def: "increase in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "increased IL-15 secretion" EXACT []
synonym: "increased IL15 secretion" EXACT []
is_a: MP:0008674 ! abnormal interleukin-15 secretion

[Term]
id: MP:0008676
name: decreased interleukin-15 secretion
def: "reduction in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2" [MESH:D12.644.276.374.465.515]
synonym: "decreased IL-15 secretion" EXACT []
synonym: "decreased IL15 secretion" EXACT []
synonym: "reduced IL-15 secretion" EXACT []
synonym: "reduced IL15 secretion" EXACT []
is_a: MP:0008674 ! abnormal interleukin-15 secretion

[Term]
id: MP:0008677
name: abnormal interleukin-16 secretion
def: "anomaly in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "abnormal IL-16 secretion" EXACT []
synonym: "abnormal IL16 secretion" EXACT []
synonym: "abnormal LCF factor secretion" EXACT []
synonym: "abnormal lymphocyte chemoattractant factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008678
name: increased interleukin-16 secretion
def: "increase in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "increased IL-16 secretion" EXACT []
synonym: "increased IL16 secretion" EXACT []
synonym: "increased LCF factor secretion" EXACT []
synonym: "increased lymphocyte chemoattractant factor secretion" EXACT []
is_a: MP:0008677 ! abnormal interleukin-16 secretion

[Term]
id: MP:0008679
name: decreased interleukin-16 secretion
def: "reduction in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
synonym: "decreased IL-16 secretion" EXACT []
synonym: "decreased IL16 secretion" EXACT []
synonym: "decreased LCF factor secretion" EXACT []
synonym: "decreased lymphocyte chemoattractant factor secretion" EXACT []
synonym: "reduced IL-16 secretion" EXACT []
synonym: "reduced IL16 secretion" EXACT []
synonym: "reduced LCF factor secretion" EXACT []
synonym: "reduced lymphocyte chemoattractant factor secretion" EXACT []
is_a: MP:0008677 ! abnormal interleukin-16 secretion

[Term]
id: MP:0008680
name: abnormal interleukin-17 secretion
def: "anomaly in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "abnormal CTLA-8 secretion" NARROW []
synonym: "abnormal CTLA8 secretion" NARROW []
synonym: "abnormal cytokine CX2 secretion" NARROW []
synonym: "abnormal cytotoxic T lymphocyte-associated antigen 8 secretion" NARROW []
synonym: "abnormal IL-17 secretion" EXACT []
synonym: "abnormal IL17 secretion" EXACT []
synonym: "abnormal ML-1 secretion" NARROW []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008681
name: increased interleukin-17 secretion
def: "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "increased CTLA-8 secretion" NARROW []
synonym: "increased CTLA8 secretion" NARROW []
synonym: "increased cytokine CX2 secretion" NARROW []
synonym: "increased cytotoxic T lymphocyte-associated antigen 8 secretion" NARROW []
synonym: "increased IL-17 secretion" EXACT []
synonym: "increased IL17 secretion" EXACT []
synonym: "increased ML-1 secretion" NARROW []
is_a: MP:0008680 ! abnormal interleukin-17 secretion

[Term]
id: MP:0008682
name: decreased interleukin-17 secretion
def: "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
comment: Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
synonym: "decreased CTLA-8 secretion" NARROW []
synonym: "decreased CTLA8 secretion" NARROW []
synonym: "decreased cytokine CX2 secretion" NARROW []
synonym: "decreased cytotoxic T lymphocyte-associated antigen 8 secretion" NARROW []
synonym: "decreased IL-17 secretion" EXACT []
synonym: "decreased IL17 secretion" EXACT []
synonym: "decreased ML-1 secretion" NARROW []
synonym: "reduced CTLA-8 secretion" NARROW []
synonym: "reduced CTLA8 secretion" NARROW []
synonym: "reduced cytokine CX2 secretion" NARROW []
synonym: "reduced cytotoxic T lymphocyte-associated antigen 8 secretion" NARROW []
synonym: "reduced IL-17 secretion" EXACT []
synonym: "reduced IL17 secretion" EXACT []
synonym: "reduced ML-1 secretion" NARROW []
is_a: MP:0008680 ! abnormal interleukin-17 secretion

[Term]
id: MP:0008683
name: abnormal interleukin-18 secretion
def: "anomaly in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "abnormal IFN-gamma inducing factor secretion" EXACT []
synonym: "abnormal IL-18 secretion" EXACT []
synonym: "abnormal IL18 secretion" EXACT []
synonym: "abnormal interferon-gamma inducing factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008684
name: increased interleukin-18 secretion
def: "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "increased IFN-gamma inducing factor secretion" EXACT []
synonym: "increased IL-18 secretion" EXACT []
synonym: "increased IL18 secretion" EXACT []
synonym: "increased interferon-gamma inducing factor secretion" EXACT []
is_a: MP:0008683 ! abnormal interleukin-18 secretion

[Term]
id: MP:0008685
name: decreased interleukin-18 secretion
def: "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
synonym: "decreased IFN-gamma inducing factor secretion" EXACT []
synonym: "decreased IL-18 secretion" EXACT []
synonym: "decreased IL18 secretion" EXACT []
synonym: "decreased interferon-gamma inducing factor secretion" EXACT []
synonym: "reduced IFN-gamma inducing factor secretion" EXACT []
synonym: "reduced IL-18 secretion" EXACT []
synonym: "reduced IL18 secretion" EXACT []
synonym: "reduced interferon-gamma inducing factor secretion" EXACT []
is_a: MP:0008683 ! abnormal interleukin-18 secretion

[Term]
id: MP:0008686
name: abnormal interleukin-2 secretion
def: "anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "abnormal IL-2 secretion" EXACT []
synonym: "abnormal IL2 secretion" EXACT []
synonym: "abnormal interleukin II secretion" EXACT []
synonym: "abnormal interleukine 2 secretion" EXACT []
synonym: "abnormal lymphocyte mitogenic factor secretion" EXACT []
synonym: "abnormal Ro-23-6019 secretion" EXACT []
synonym: "abnormal Ro-236019 secretion" EXACT []
synonym: "abnormal RU 49637 secretion" EXACT []
synonym: "abnormal RU-49637 secretion" EXACT []
synonym: "abnormal T-cell growth factor secretion" EXACT []
synonym: "abnormal T-cell stimulating factor secretion" EXACT []
synonym: "abnormal TCGF secretion" EXACT []
synonym: "abnormal thymocyte stimulating factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008687
name: increased interleukin-2 secretion
def: "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "increased IL-2 secretion" EXACT []
synonym: "increased IL2 secretion" EXACT []
synonym: "increased interleukin II secretion" EXACT []
synonym: "increased interleukine 2 secretion" EXACT []
synonym: "increased lymphocyte mitogenic factor secretion" EXACT []
synonym: "increased Ro-23-6019 secretion" EXACT []
synonym: "increased Ro-236019 secretion" EXACT []
synonym: "increased RU 49637 secretion" EXACT []
synonym: "increased RU-49637 secretion" EXACT []
synonym: "increased T-cell growth factor secretion" EXACT []
synonym: "increased T-cell stimulating factor secretion" EXACT []
synonym: "increased TCGF secretion" EXACT []
synonym: "increased thymocyte stimulating factor secretion" EXACT []
is_a: MP:0008686 ! abnormal interleukin-2 secretion

[Term]
id: MP:0008688
name: decreased interleukin-2 secretion
def: "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
synonym: "decreased IL-2 secretion" EXACT []
synonym: "decreased IL2 secretion" EXACT []
synonym: "decreased interleukin II secretion" EXACT []
synonym: "decreased interleukine 2 secretion" EXACT []
synonym: "decreased lymphocyte mitogenic factor secretion" EXACT []
synonym: "decreased Ro-23-6019 secretion" EXACT []
synonym: "decreased Ro-236019 secretion" EXACT []
synonym: "decreased RU 49637 secretion" EXACT []
synonym: "decreased RU-49637 secretion" EXACT []
synonym: "decreased T-cell growth factor secretion" EXACT []
synonym: "decreased T-cell stimulating factor secretion" EXACT []
synonym: "decreased TCGF secretion" EXACT []
synonym: "decreased thymocyte stimulating factor secretion" EXACT []
synonym: "reduced IL-2 secretion" EXACT []
synonym: "reduced IL2 secretion" EXACT []
synonym: "reduced interleukin II secretion" EXACT []
synonym: "reduced interleukine 2 secretion" EXACT []
synonym: "reduced lymphocyte mitogenic factor secretion" EXACT []
synonym: "reduced Ro-23-6019 secretion" EXACT []
synonym: "reduced Ro-236019 secretion" EXACT []
synonym: "reduced RU 49637 secretion" EXACT []
synonym: "reduced RU-49637 secretion" EXACT []
synonym: "reduced T-cell growth factor secretion" EXACT []
synonym: "reduced T-cell stimulating factor secretion" EXACT []
synonym: "reduced TCGF secretion" EXACT []
synonym: "reduced thymocyte stimulating factor secretion" EXACT []
is_a: MP:0008686 ! abnormal interleukin-2 secretion

[Term]
id: MP:0008689
name: abnormal interleukin-23 secretion
def: "anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "abnormal IL-23 secretion" EXACT []
synonym: "abnormal IL23 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008690
name: increased interleukin-23 secretion
def: "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "increased IL-23 secretion" EXACT []
synonym: "increased IL23 secretion" EXACT []
is_a: MP:0008689 ! abnormal interleukin-23 secretion

[Term]
id: MP:0008691
name: decreased interleukin-23 secretion
def: "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
comment: Interleukin-23 is comprised of a unique 19 kDa subunit (IL-23a) and 40 kDa subunit (IL-12b) that is shared with interleukin-12.
synonym: "decreased IL-23 secretion" EXACT []
synonym: "decreased IL23 secretion" EXACT []
synonym: "reduced IL-23 secretion" EXACT []
synonym: "reduced IL23 secretion" EXACT []
is_a: MP:0008689 ! abnormal interleukin-23 secretion

[Term]
id: MP:0008692
name: abnormal interleukin-23a secretion
def: "anomaly in the production or release of the p19 subunit of interleukin-23" [MESH:D12.644.276.374.465.759.500]
synonym: "abnormal IL-23 alpha secretion" EXACT []
synonym: "abnormal IL-23 p19 secretion" EXACT []
synonym: "abnormal IL-23a secretion" EXACT []
synonym: "abnormal IL-23p19 secretion" EXACT []
synonym: "abnormal interleukin-23 alpha secretion" EXACT []
synonym: "abnormal interleukin-23p19 secretion" EXACT []
is_a: MP:0008689 ! abnormal interleukin-23 secretion

[Term]
id: MP:0008693
name: increased interleukin-23a secretion
def: "increase in the production or release of the p19 subunit of interleukin-23" [MESH:D12.644.276.374.465.759.500]
synonym: "increased IL-23 alpha secretion" EXACT []
synonym: "increased IL-23 p19 secretion" EXACT []
synonym: "increased IL-23a secretion" EXACT []
synonym: "increased IL-23p19 secretion" EXACT []
synonym: "increased interleukin-23 alpha secretion" EXACT []
synonym: "increased interleukin-23p19 secretion" EXACT []
is_a: MP:0008692 ! abnormal interleukin-23a secretion

[Term]
id: MP:0008694
name: decreased interleukin-23a secretion
def: "reduction in the production or release of the p19 subunit of interleukin-23" [MESH:D12.644.276.374.465.759.500]
synonym: "decreased IL-23 alpha secretion" EXACT []
synonym: "decreased IL-23 p19 secretion" EXACT []
synonym: "decreased IL-23a secretion" EXACT []
synonym: "decreased IL-23p19 secretion" EXACT []
synonym: "decreased interleukin-23 alpha secretion" EXACT []
synonym: "decreased interleukin-23p19 secretion" EXACT []
synonym: "reduced IL-23 alpha secretion" EXACT []
synonym: "reduced IL-23 p19 secretion" EXACT []
synonym: "reduced IL-23a secretion" EXACT []
synonym: "reduced IL-23p19 secretion" EXACT []
synonym: "reduced interleukin-23 alpha secretion" EXACT []
synonym: "reduced interleukin-23p19 secretion" EXACT []
is_a: MP:0008692 ! abnormal interleukin-23a secretion

[Term]
id: MP:0008695
name: abnormal interleukin-3 secretion
def: "anomaly in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "abnormal colony-stimulating factor 2 alpha secretion" EXACT []
synonym: "abnormal eosinophil-mast cell growth-factor secretion" EXACT []
synonym: "abnormal erythrocyte burst-promoting factor secretion" EXACT []
synonym: "abnormal haematopoietin-2 secretion" EXACT []
synonym: "abnormal hematopoietin-2 secretion" EXACT []
synonym: "abnormal IL-3 secretion" EXACT []
synonym: "abnormal IL3 secretion" EXACT []
synonym: "abnormal mast-cell colony-stimulating factor secretion" EXACT []
synonym: "abnormal multipotential colony-stimulating factor secretion" EXACT []
synonym: "abnormal P-cell stimulating factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008696
name: increased interleukin-3 secretion
def: "increase in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "increased colony-stimulating factor 2 alpha secretion" EXACT []
synonym: "increased eosinophil-mast cell growth-factor secretion" EXACT []
synonym: "increased erythrocyte burst-promoting factor secretion" EXACT []
synonym: "increased haematopoietin-2 secretion" EXACT []
synonym: "increased hematopoietin-2 secretion" EXACT []
synonym: "increased IL-3 secretion" EXACT []
synonym: "increased IL3 secretion" EXACT []
synonym: "increased mast-cell colony-stimulating factor secretion" EXACT []
synonym: "increased multipotential colony-stimulating factor secretion" EXACT []
synonym: "increased P-cell stimulating factor secretion" EXACT []
is_a: MP:0008695 ! abnormal interleukin-3 secretion

[Term]
id: MP:0008697
name: decreased interleukin-3 secretion
def: "reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
synonym: "decreased colony-stimulating factor 2 alpha secretion" EXACT []
synonym: "decreased eosinophil-mast cell growth-factor secretion" EXACT []
synonym: "decreased erythrocyte burst-promoting factor secretion" EXACT []
synonym: "decreased haematopoietin-2 secretion" EXACT []
synonym: "decreased hematopoietin-2 secretion" EXACT []
synonym: "decreased IL-3 secretion" EXACT []
synonym: "decreased IL3 secretion" EXACT []
synonym: "decreased mast-cell colony-stimulating factor secretion" EXACT []
synonym: "decreased multipotential colony-stimulating factor secretion" EXACT []
synonym: "decreased P-cell stimulating factor secretion" EXACT []
synonym: "reduced colony-stimulating factor 2 alpha secretion" EXACT []
synonym: "reduced eosinophil-mast cell growth-factor secretion" EXACT []
synonym: "reduced erythrocyte burst-promoting factor secretion" EXACT []
synonym: "reduced haematopoietin-2 secretion" EXACT []
synonym: "reduced hematopoietin-2 secretion" EXACT []
synonym: "reduced IL-3 secretion" EXACT []
synonym: "reduced IL3 secretion" EXACT []
synonym: "reduced mast-cell colony-stimulating factor secretion" EXACT []
synonym: "reduced multipotential colony-stimulating factor secretion" EXACT []
synonym: "reduced P-cell stimulating factor secretion" EXACT []
is_a: MP:0008695 ! abnormal interleukin-3 secretion

[Term]
id: MP:0008698
name: abnormal interleukin-4 secretion
def: "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "abnormal B cell stimulatory factor-1 secretion" EXACT []
synonym: "abnormal B-cell growth factor-1 secretion" EXACT []
synonym: "abnormal B-cell growth factor-I secretion" EXACT []
synonym: "abnormal B-cell proliferating factor secretion" EXACT []
synonym: "abnormal B-cell stimulating factor-1 secretion" EXACT []
synonym: "abnormal B-cell stimulatory factor 1 secretion" EXACT []
synonym: "abnormal B-cell stimulatory factor-1 secretion" EXACT []
synonym: "abnormal BCGF-1 secretion" EXACT []
synonym: "abnormal Binetrakin secretion" EXACT []
synonym: "abnormal BSF-1 secretion" EXACT []
synonym: "abnormal IL-4 secretion" EXACT []
synonym: "abnormal IL4 secretion" EXACT []
synonym: "abnormal mast cell growth factor-2 secretion" EXACT []
synonym: "abnormal MCGF-2 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008699
name: increased interleukin-4 secretion
def: "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "increased B cell stimulatory factor-1 secretion" EXACT []
synonym: "increased B-cell growth factor-1 secretion" EXACT []
synonym: "increased B-cell growth factor-I secretion" EXACT []
synonym: "increased B-cell proliferating factor secretion" EXACT []
synonym: "increased B-cell stimulating factor-1 secretion" EXACT []
synonym: "increased B-cell stimulatory factor 1 secretion" EXACT []
synonym: "increased B-cell stimulatory factor-1 secretion" EXACT []
synonym: "increased BCGF-1 secretion" EXACT []
synonym: "increased Binetrakin secretion" EXACT []
synonym: "increased BSF-1 secretion" EXACT []
synonym: "increased IL-4 secretion" EXACT []
synonym: "increased IL4 secretion" EXACT []
synonym: "increased mast cell growth factor-2 secretion" EXACT []
synonym: "increased MCGF-2 secretion" EXACT []
is_a: MP:0008698 ! abnormal interleukin-4 secretion

[Term]
id: MP:0008700
name: decreased interleukin-4 secretion
def: "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
synonym: "decreased B cell stimulatory factor-1 secretion" EXACT []
synonym: "decreased B-cell growth factor-1 secretion" EXACT []
synonym: "decreased B-cell growth factor-I secretion" EXACT []
synonym: "decreased B-cell proliferating factor secretion" EXACT []
synonym: "decreased B-cell stimulating factor-1 secretion" EXACT []
synonym: "decreased B-cell stimulatory factor 1 secretion" EXACT []
synonym: "decreased B-cell stimulatory factor-1 secretion" EXACT []
synonym: "decreased BCGF-1 secretion" EXACT []
synonym: "decreased Binetrakin secretion" EXACT []
synonym: "decreased BSF-1 secretion" EXACT []
synonym: "decreased IL-4 secretion" EXACT []
synonym: "decreased IL4 secretion" EXACT []
synonym: "decreased mast cell growth factor-2 secretion" EXACT []
synonym: "decreased MCGF-2 secretion" EXACT []
synonym: "reduced B cell stimulatory factor-1 secretion" EXACT []
synonym: "reduced B-cell growth factor-1 secretion" EXACT []
synonym: "reduced B-cell growth factor-I secretion" EXACT []
synonym: "reduced B-cell proliferating factor secretion" EXACT []
synonym: "reduced B-cell stimulating factor-1 secretion" EXACT []
synonym: "reduced B-cell stimulatory factor 1 secretion" EXACT []
synonym: "reduced B-cell stimulatory factor-1 secretion" EXACT []
synonym: "reduced BCGF-1 secretion" EXACT []
synonym: "reduced Binetrakin secretion" EXACT []
synonym: "reduced BSF-1 secretion" EXACT []
synonym: "reduced IL-4 secretion" EXACT []
synonym: "reduced IL4 secretion" EXACT []
synonym: "reduced mast cell growth factor-2 secretion" EXACT []
synonym: "reduced MCGF-2 secretion" EXACT []
is_a: MP:0008698 ! abnormal interleukin-4 secretion

[Term]
id: MP:0008701
name: abnormal interleukin-5 secretion
def: "anomaly in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "abnormal B-cell growth factor-II secretion" EXACT []
synonym: "abnormal BCGF-II secretion" EXACT []
synonym: "abnormal eosinophil differentiation factor secretion" EXACT []
synonym: "abnormal IL-5 secretion" EXACT []
synonym: "abnormal IL5 secretion" EXACT []
synonym: "abnormal T-cell replacing factor secretion" EXACT []
synonym: "abnormal T-cell-replacing factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008702
name: increased interleukin-5 secretion
def: "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "increased B-cell growth factor-II secretion" EXACT []
synonym: "increased BCGF-II secretion" EXACT []
synonym: "increased eosinophil differentiation factor secretion" EXACT []
synonym: "increased IL-5 secretion" EXACT []
synonym: "increased IL5 secretion" EXACT []
synonym: "increased T-cell replacing factor secretion" EXACT []
synonym: "increased T-cell-replacing factor secretion" EXACT []
is_a: MP:0008701 ! abnormal interleukin-5 secretion

[Term]
id: MP:0008703
name: decreased interleukin-5 secretion
def: "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
synonym: "decreased B-cell growth factor-II secretion" EXACT []
synonym: "decreased BCGF-II secretion" EXACT []
synonym: "decreased eosinophil differentiation factor secretion" EXACT []
synonym: "decreased IL-5 secretion" EXACT []
synonym: "decreased IL5 secretion" EXACT []
synonym: "decreased T-cell replacing factor secretion" EXACT []
synonym: "decreased T-cell-replacing factor secretion" EXACT []
synonym: "reduced B-cell growth factor-II secretion" EXACT []
synonym: "reduced BCGF-II secretion" EXACT []
synonym: "reduced eosinophil differentiation factor secretion" EXACT []
synonym: "reduced IL-5 secretion" EXACT []
synonym: "reduced IL5 secretion" EXACT []
synonym: "reduced T-cell replacing factor secretion" EXACT []
synonym: "reduced T-cell-replacing factor secretion" EXACT []
is_a: MP:0008701 ! abnormal interleukin-5 secretion

[Term]
id: MP:0008704
name: abnormal interleukin-6 secretion
def: "anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "abnormal B cell stimulatory factor-2 secretion" EXACT []
synonym: "abnormal B-cell differentiation factor secretion" EXACT []
synonym: "abnormal B-cell differentiation factor-2 secretion" EXACT []
synonym: "abnormal B-cell stimulatory factor 2 secretion" EXACT []
synonym: "abnormal B-cell stimulatory factor-2 secretion" EXACT []
synonym: "abnormal BSF-2 secretion" EXACT []
synonym: "abnormal hepatocyte-stimulating factor secretion" EXACT []
synonym: "abnormal hybridoma growth factor secretion" EXACT []
synonym: "abnormal IFN-beta 2 secretion" EXACT []
synonym: "abnormal IL-6 secretion" EXACT []
synonym: "abnormal IL6 secretion" EXACT []
synonym: "abnormal MGI-2 secretion" EXACT []
synonym: "abnormal myeloid differentiation-inducing protein secretion" EXACT []
synonym: "abnormal plasmacytoma growth factor secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008705
name: increased interleukin-6 secretion
def: "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "increased B cell stimulatory factor-2 secretion" EXACT []
synonym: "increased B-cell differentiation factor secretion" EXACT []
synonym: "increased B-cell differentiation factor-2 secretion" EXACT []
synonym: "increased B-cell stimulatory factor 2 secretion" EXACT []
synonym: "increased B-cell stimulatory factor-2 secretion" EXACT []
synonym: "increased BSF-2 secretion" EXACT []
synonym: "increased hepatocyte-stimulating factor secretion" EXACT []
synonym: "increased hybridoma growth factor secretion" EXACT []
synonym: "increased IFN-beta 2 secretion" EXACT []
synonym: "increased IL-6 secretion" EXACT []
synonym: "increased IL6 secretion" EXACT []
synonym: "increased MGI-2 secretion" EXACT []
synonym: "increased myeloid differentiation-inducing protein secretion" EXACT []
synonym: "increased plasmacytoma growth factor secretion" EXACT []
is_a: MP:0008704 ! abnormal interleukin-6 secretion

[Term]
id: MP:0008706
name: decreased interleukin-6 secretion
def: "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
synonym: "decreased B cell stimulatory factor-2 secretion" EXACT []
synonym: "decreased B-cell differentiation factor secretion" EXACT []
synonym: "decreased B-cell differentiation factor-2 secretion" EXACT []
synonym: "decreased B-cell stimulatory factor 2 secretion" EXACT []
synonym: "decreased B-cell stimulatory factor-2 secretion" EXACT []
synonym: "decreased BSF-2 secretion" EXACT []
synonym: "decreased hepatocyte-stimulating factor secretion" EXACT []
synonym: "decreased hybridoma growth factor secretion" EXACT []
synonym: "decreased IFN-beta 2 secretion" EXACT []
synonym: "decreased IL-6 secretion" EXACT []
synonym: "decreased IL6 secretion" EXACT []
synonym: "decreased MGI-2 secretion" EXACT []
synonym: "decreased myeloid differentiation-inducing protein secretion" EXACT []
synonym: "decreased plasmacytoma growth factor secretion" EXACT []
synonym: "reduced B cell stimulatory factor-2 secretion" EXACT []
synonym: "reduced B-cell differentiation factor secretion" EXACT []
synonym: "reduced B-cell differentiation factor-2 secretion" EXACT []
synonym: "reduced B-cell stimulatory factor 2 secretion" EXACT []
synonym: "reduced B-cell stimulatory factor-2 secretion" EXACT []
synonym: "reduced BSF-2 secretion" EXACT []
synonym: "reduced hepatocyte-stimulating factor secretion" EXACT []
synonym: "reduced hybridoma growth factor secretion" EXACT []
synonym: "reduced IFN-beta 2 secretion" EXACT []
synonym: "reduced IL-6 secretion" EXACT []
synonym: "reduced IL6 secretion" EXACT []
synonym: "reduced MGI-2 secretion" EXACT []
synonym: "reduced myeloid differentiation-inducing protein secretion" EXACT []
synonym: "reduced plasmacytoma growth factor secretion" EXACT []
is_a: MP:0008704 ! abnormal interleukin-6 secretion

[Term]
id: MP:0008707
name: abnormal interleukin-7 secretion
def: "anomaly in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "abnormal IL-7 secretion" EXACT []
synonym: "abnormal IL7 secretion" EXACT []
synonym: "abnormal lymphopoietin-1 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008708
name: increased interleukin-7 secretion
def: "increase in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "increased IL-7 secretion" EXACT []
synonym: "increased IL7 secretion" EXACT []
synonym: "increased lymphopoietin-1 secretion" EXACT []
is_a: MP:0008707 ! abnormal interleukin-7 secretion

[Term]
id: MP:0008709
name: decreased interleukin-7 secretion
def: "reduction in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation" [MESH:D12.644.276.374.465.507]
synonym: "decreased IL-7 secretion" EXACT []
synonym: "decreased IL7 secretion" EXACT []
synonym: "decreased lymphopoietin-1 secretion" EXACT []
synonym: "reduced IL-7 secretion" EXACT []
synonym: "reduced IL7 secretion" EXACT []
synonym: "reduced lymphopoietin-1 secretion" EXACT []
is_a: MP:0008707 ! abnormal interleukin-7 secretion

[Term]
id: MP:0008710
name: abnormal interleukin-9 secretion
def: "anomaly in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "abnormal IL-9 secretion" EXACT []
synonym: "abnormal IL9 secretion" EXACT []
synonym: "abnormal P40 T-Cell Growth Factor secretion" EXACT []
synonym: "abnormal T-Cell Growth Factor P40 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0008711
name: increased interleukin-9 secretion
def: "increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "increased IL-9 secretion" EXACT []
synonym: "increased IL9 secretion" EXACT []
synonym: "increased P40 T-Cell Growth Factor secretion" EXACT []
synonym: "increased T-Cell Growth Factor P40 secretion" EXACT []
is_a: MP:0008710 ! abnormal interleukin-9 secretion

[Term]
id: MP:0008712
name: decreased interleukin-9 secretion
def: "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
synonym: "decreased IL-9 secretion" EXACT []
synonym: "decreased IL9 secretion" EXACT []
synonym: "decreased P40 T-Cell Growth Factor secretion" EXACT []
synonym: "decreased T-Cell Growth Factor P40 secretion" EXACT []
synonym: "reduced IL-9 secretion" EXACT []
synonym: "reduced IL9 secretion" EXACT []
synonym: "reduced P40 T-Cell Growth Factor secretion" EXACT []
synonym: "reduced T-Cell Growth Factor P40 secretion" EXACT []
is_a: MP:0008710 ! abnormal interleukin-9 secretion

[Term]
id: MP:0008713
name: abnormal cytokine level
def: "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-8153-1691-7]
is_a: MP:0002723 ! abnormal immune serum protein physiology
is_a: MP:0008835 ! abnormal intercellular signaling peptide or protein level

[Term]
id: MP:0008714
name: increased lung carcinoma incidence
def: "greater than the expected number of a malignant neoplasm of the lung, arising from epithelial cells, usually glandular or squamous, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "lung carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0008014 ! increased lung tumor incidence

[Term]
id: MP:0008715
name: increased lung small cell carcinoma incidence
def: "greater than the expected number of an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm, occurring in a specific population in a given time period" [MESH:C04.557.465.625.650.240.390]
synonym: "lung small cell carcinoma" RELATED []
is_a: MP:0008714 ! increased lung carcinoma incidence

[Term]
id: MP:0008716
name: increased lung non-small cell carcinoma incidence
def: "greater than the expected number of a heterogeneous aggregate of at least three distinct histological types of lung cancer, occurring in a specific population in a given time period" [MESH:C04.557.470.200.300]
synonym: "lung non-small cell carcinoma" RELATED []
is_a: MP:0008714 ! increased lung carcinoma incidence

[Term]
id: MP:0008717
name: increased lung squamous cell carcinoma incidence
def: "greater than the expected number of a lung carcinoma derived from stratified squamous epithelium, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "lung SCC" RELATED []
synonym: "lung squamous cell carcinoma" RELATED []
is_a: MP:0004207 ! increased squamous cell carcinoma incidence
is_a: MP:0008716 ! increased lung non-small cell carcinoma incidence

[Term]
id: MP:0008718
name: increased lung large cell carcinoma incidence
def: "greater than the expected number of a bronchogenic tumor of undifferentiated (anaplastic) cells of large size, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "lung large cell carcinoma" RELATED []
is_a: MP:0008716 ! increased lung non-small cell carcinoma incidence

[Term]
id: MP:0008719
name: impaired neutrophil recruitment
def: "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002463 ! abnormal neutrophil physiology

[Term]
id: MP:0008720
name: impaired neutrophil chemotaxis
def: "defect in the movement of neutrophils guided by a specific chemical concentration gradient" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased neutrophil migration" EXACT []
synonym: "impaired neutrophil migration" EXACT []
synonym: "reduced neutrophil migration" EXACT []
is_a: MP:0002463 ! abnormal neutrophil physiology
is_a: MP:0011518 ! abnormal cell chemotaxis

[Term]
id: MP:0008721
name: abnormal chemokine level
def: "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
is_a: MP:0008713 ! abnormal cytokine level

[Term]
id: MP:0008722
name: abnormal chemokine secretion
def: "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
is_a: MP:0003009 ! abnormal cytokine secretion

[Term]
id: MP:0008723
name: impaired eosinophil recruitment
def: "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased eosinophil recruitment" EXACT []
is_a: MP:0002465 ! abnormal eosinophil physiology

[Term]
id: MP:0008724
name: impaired eosinophil chemotaxis
def: "defect in the movement of eosinophils guided by a specific chemical concentration gradient" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased eosinophil migration" EXACT []
synonym: "impaired eosinophil migration" EXACT []
synonym: "reduced eosinophil migration" EXACT []
is_a: MP:0002465 ! abnormal eosinophil physiology
is_a: MP:0011518 ! abnormal cell chemotaxis

[Term]
id: MP:0008725
name: increased heart atrium size
def: "increased average size of either one or both of the heart atria compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723, MESH:A07.541.358]
synonym: "enlarged heart atria" EXACT []
synonym: "enlarged heart atrium" EXACT []
synonym: "increased cardiac atrium size" EXACT []
synonym: "increased heart atrial size" EXACT []
is_a: MP:0031576 ! abnormal heart atrium size

[Term]
id: MP:0008726
name: increased heart left atrium size
def: "increased size of the left upper chamber of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "enlarged heart left atrium" EXACT []
synonym: "enlarged left atrium" EXACT []
synonym: "giant left atrium" EXACT []
synonym: "increased cardiac left atrium size" EXACT []
synonym: "increased heart LA size" EXACT []
synonym: "increased heart left atrial size" EXACT []
xref: Fyler:3011
is_a: MP:0003923 ! abnormal heart left atrium morphology
is_a: MP:0008725 ! increased heart atrium size

[Term]
id: MP:0008727
name: increased heart right atrium size
def: "increased size of the right upper chamber of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "enlarged heart right atrium" EXACT []
synonym: "enlarged right atrium" EXACT []
synonym: "giant right atrium" EXACT []
synonym: "increased cardiac right atrium size" EXACT []
synonym: "increased heart RA size" EXACT []
synonym: "increased heart right atrial size" EXACT []
xref: Fyler:1771
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0008725 ! increased heart atrium size

[Term]
id: MP:0008728
name: increased memory B cell number
def: "greater number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008093 ! abnormal memory B cell number
is_a: MP:0013769 ! increased marginal zone precursor B cell number

[Term]
id: MP:0008729
name: decreased memory B cell number
def: "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149]
is_a: MP:0008093 ! abnormal memory B cell number
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0008730
name: fused phalanges
def: "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "fused digits" BROAD []
synonym: "fusion of phalanges" EXACT []
synonym: "phalanges fusion" EXACT []
is_a: MP:0000564 ! syndactyly
is_a: MP:0005306 ! abnormal phalanx morphology

[Term]
id: MP:0008731
name: abnormal hair shaft melanin granule morphology
def: "any structural anomaly of pigment polymers in the hair shaft" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
is_a: MP:0003809 ! abnormal hair shaft morphology
is_a: MP:0005075 ! abnormal melanosome morphology

[Term]
id: MP:0008732
name: reduced hair shaft melanin granule number
def: "the number of pigment polymers in the hair shaft is less than normal" [MGI:llw2]
is_a: MP:0008731 ! abnormal hair shaft melanin granule morphology

[Term]
id: MP:0008733
name: abnormal hair shaft melanin granule distribution
def: "disruption in the regular arrangement of pigment polymers in the hair shaft" [MGI:llw2]
is_a: MP:0008731 ! abnormal hair shaft melanin granule morphology

[Term]
id: MP:0008734
name: decreased susceptibility to endotoxin shock
def: "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [https://orcid.org/0000-0003-1980-3228]
synonym: "decreased response to LPS induced shock" NARROW []
synonym: "decreased sensitivity to endotoxic shock" EXACT []
synonym: "decreased sensitivity to endotoxin shock" EXACT []
synonym: "increased resistance to endotoxin shock" EXACT []
is_a: MP:0005087 ! decreased acute inflammation

[Term]
id: MP:0008735
name: increased susceptibility to endotoxin shock
def: "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [https://orcid.org/0000-0003-1980-3228]
synonym: "decreased resistance to endotoxic shock" EXACT []
synonym: "decreased resistance to endotoxin shock" EXACT []
synonym: "increased response to LPS induced shock" NARROW []
synonym: "increased sensitivity to endotoxic shock" EXACT []
synonym: "increased sensitivity to endotoxin shock" EXACT []
synonym: "increased susceptibility to endotoxic shock" EXACT []
is_a: MP:0005088 ! increased acute inflammation

[Term]
id: MP:0008736
name: micromelia
def: "disproportionately short or small limbs" [MGI:llw2]
synonym: "nanomelia" EXACT []
is_a: MP:0000547 ! short limbs

[Term]
id: MP:0008737
name: abnormal spleen physiology
def: "any functional anomaly of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2]
is_a: MP:0003762 ! abnormal immune organ physiology

[Term]
id: MP:0008738
name: abnormal liver iron level
def: "anomaly in the amount of iron present in the liver tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal hepatic iron level" EXACT []
synonym: "abnormal hepatic iron load" EXACT []
synonym: "abnormal liver iron load" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0001770 ! abnormal iron level

[Term]
id: MP:0008739
name: abnormal spleen iron level
def: "anomaly in the amount of iron present in the spleen tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal spleen iron load" EXACT []
synonym: "abnormal splenic iron level" EXACT []
synonym: "abnormal splenic iron load" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology
is_a: MP:0001770 ! abnormal iron level

[Term]
id: MP:0008740
name: abnormal intestine iron level
def: "anomaly in the amount of iron present in the large or small intestinal tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal intestinal iron level" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0001770 ! abnormal iron level

[Term]
id: MP:0008741
name: abnormal heart iron level
def: "anomaly in the amount of iron present in the heart tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cardiac iron level" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0001770 ! abnormal iron level

[Term]
id: MP:0008742
name: abnormal kidney iron level
def: "anomaly in the amount of iron present in the kidney tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal renal iron level" EXACT []
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0008743
name: decreased liver iron level
def: "reduction in the amount of iron present in the liver tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased hepatic iron level" EXACT []
synonym: "decreased hepatic iron load" EXACT []
synonym: "decreased liver iron load" EXACT []
synonym: "reduced hepatic iron level" EXACT []
synonym: "reduced liver iron level" EXACT []
is_a: MP:0008738 ! abnormal liver iron level
is_a: MP:0014542 ! decreased iron level

[Term]
id: MP:0008744
name: abnormal B cell anergy
def: "any anomaly in the process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction" [GO:0002515]
synonym: "abnormal B lymphocyte anergy" EXACT []
synonym: "abnormal B-cell anergy" EXACT []
synonym: "abnormal B-lymphocyte anergy" EXACT []
is_a: MP:0005004 ! abnormal lymphocyte anergy

[Term]
id: MP:0008745
name: abnormal central B cell anergy
def: "any anomaly of the processes of B cell anergy that occur in the bone marrow" [GO:0002341]
synonym: "abnormal central B lymphocyte anergy" EXACT []
synonym: "abnormal central B-cell anergy" EXACT []
synonym: "abnormal central B-lymphocyte anergy" EXACT []
is_a: MP:0008744 ! abnormal B cell anergy

[Term]
id: MP:0008746
name: abnormal peripheral B cell anergy
def: "any anomaly of the processes of B cell anergy that occur outside the bone marrow" [GO:0002453]
synonym: "abnormal peripheral B lymphocyte anergy" EXACT []
synonym: "abnormal peripheral B-cell anergy" EXACT []
synonym: "abnormal peripheral B-lymphocyte anergy" EXACT []
is_a: MP:0008744 ! abnormal B cell anergy

[Term]
id: MP:0008747
name: abnormal T cell anergy
def: "any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction" [GO:0002870]
synonym: "abnormal T lymphocyte anergy" EXACT []
synonym: "abnormal T-cell anergy" EXACT []
synonym: "abnormal T-lymphocyte anergy" EXACT []
is_a: MP:0005004 ! abnormal lymphocyte anergy

[Term]
id: MP:0008748
name: abnormal central T cell anergy
def: "any anomaly of the processes of T cell anergy that occur in the thymus" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal central T lymphocyte anergy" EXACT []
synonym: "abnormal central T-cell anergy" EXACT []
synonym: "abnormal central T-lymphocyte anergy" EXACT []
is_a: MP:0008747 ! abnormal T cell anergy

[Term]
id: MP:0008749
name: abnormal peripheral T cell anergy
def: "any anomaly of the processes of T cell anergy that occur outside the thymus" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal peripheral T lymphocyte anergy" EXACT []
synonym: "abnormal peripheral T-cell anergy" EXACT []
synonym: "abnormal peripheral T-lymphocyte anergy" EXACT []
is_a: MP:0008747 ! abnormal T cell anergy

[Term]
id: MP:0008750
name: abnormal interferon level
def: "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
is_a: MP:0008713 ! abnormal cytokine level

[Term]
id: MP:0008751
name: abnormal interleukin level
def: "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
is_a: MP:0008713 ! abnormal cytokine level

[Term]
id: MP:0008752
name: abnormal tumor necrosis factor level
def: "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
synonym: "abnormal cachectin level" EXACT []
synonym: "abnormal TNF level" EXACT []
synonym: "abnormal TNFA level" EXACT []
synonym: "abnormal tumor necrosis factor alpha level" EXACT []
synonym: "abnormal tumour necrosis factor alpha level" EXACT []
synonym: "abnormal tumour necrosis factor level" EXACT []
is_a: MP:0008713 ! abnormal cytokine level

[Term]
id: MP:0008753
name: abnormal osteocyte morphology
def: "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in a small cavity called lacuna and that extends cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [PMID:24042263]
is_a: MP:0004986 ! abnormal osteoblast morphology
is_a: MP:0030485 ! abnormal osteocyte lacunocanalicular system morphology

[Term]
id: MP:0008754
name: abnormal T cell receptor V(D)J recombination
def: "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal T cell receptor V(D)J joining" EXACT []
synonym: "abnormal T cell receptor V(D)J rearrangement" EXACT []
synonym: "abnormal T cell receptor V-D-J joining" EXACT []
synonym: "abnormal T cell receptor V-D-J rearrangement" EXACT []
synonym: "abnormal T cell receptor V-D-J recombination" EXACT []
synonym: "abnormal T cell receptor V-J joining" EXACT []
synonym: "abnormal T cell receptor V-J rearrangement" EXACT []
synonym: "abnormal T cell receptor V-J recombination" EXACT []
synonym: "abnormal T-cell receptor V(D)J recombination" EXACT []
synonym: "abnormal TCR V(D)J recombination" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation

[Term]
id: MP:0008755
name: abnormal immunoglobulin V(D)J recombination
def: "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal immunoglobulin V(D)J joining" EXACT []
synonym: "abnormal immunoglobulin V(D)J rearrangement" EXACT []
synonym: "abnormal immunoglobulin V-D-J joining" EXACT []
synonym: "abnormal immunoglobulin V-D-J rearrangement" EXACT []
synonym: "abnormal immunoglobulin V-D-J recombination" EXACT []
synonym: "abnormal immunoglobulin V-J joining" EXACT []
synonym: "abnormal immunoglobulin V-J rearrangement" EXACT []
synonym: "abnormal immunoglobulin V-J recombination" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation

[Term]
id: MP:0008756
name: abnormal T cell receptor alpha chain V-J recombination
def: "any anomaly in the process by which V and J gene segments of the T cell receptor alpha chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal T cell receptor alpha chain V-J joining" EXACT []
synonym: "abnormal T cell receptor alpha chain V-J rearrangement" EXACT []
is_a: MP:0008754 ! abnormal T cell receptor V(D)J recombination

[Term]
id: MP:0008757
name: abnormal T cell receptor gamma chain V-J recombination
def: "any anomaly in the process by which V and J gene segments of the T cell receptor gamma chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal T cell receptor gamma chain V-J joining" EXACT []
synonym: "abnormal T cell receptor gamma chain V-J rearrangement" EXACT []
is_a: MP:0008754 ! abnormal T cell receptor V(D)J recombination

[Term]
id: MP:0008758
name: abnormal T cell receptor beta chain V(D)J recombination
def: "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal T cell receptor beta chain V(D)J joining" EXACT []
synonym: "abnormal T cell receptor beta chain V(D)J rearrangement" EXACT []
synonym: "abnormal T cell receptor beta chain V-D-J joining" EXACT []
synonym: "abnormal T cell receptor beta chain V-D-J rearrangement" EXACT []
synonym: "abnormal T cell receptor beta chain V-D-J recombination" EXACT []
synonym: "abnormal T-cell receptor beta chain V(D)J recombination" EXACT []
synonym: "abnormal TCR beta chain V(D)J recombination" EXACT []
is_a: MP:0008754 ! abnormal T cell receptor V(D)J recombination

[Term]
id: MP:0008759
name: abnormal T cell receptor delta chain V(D)J recombination
def: "any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal T cell receptor delta chain V(D)J joining" EXACT []
synonym: "abnormal T cell receptor delta chain V(D)J rearrangement" EXACT []
synonym: "abnormal T cell receptor delta chain V-D-J joining" EXACT []
synonym: "abnormal T cell receptor delta chain V-D-J rearrangement" EXACT []
synonym: "abnormal T cell receptor delta chain V-D-J recombination" EXACT []
synonym: "abnormal T-cell receptor delta chain V(D)J recombination" EXACT []
synonym: "abnormal TCR delta chain V(D)J recombination" EXACT []
is_a: MP:0008754 ! abnormal T cell receptor V(D)J recombination

[Term]
id: MP:0008760
name: abnormal immunoglobulin heavy chain V(D)J recombination
def: "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal immunoglobulin heavy chain V(D)J joining" EXACT []
synonym: "abnormal immunoglobulin heavy chain V(D)J rearrangement" EXACT []
synonym: "abnormal immunoglobulin heavy chain V-D-J joining" EXACT []
synonym: "abnormal immunoglobulin heavy chain V-D-J rearrangement" EXACT []
synonym: "abnormal immunoglobulin heavy chain V-D-J recombination" EXACT []
is_a: MP:0008755 ! abnormal immunoglobulin V(D)J recombination

[Term]
id: MP:0008761
name: abnormal immunoglobulin light chain V-J recombination
def: "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal immunoglobulin light chain V-J joining" EXACT []
synonym: "abnormal immunoglobulin light chain V-J rearrangement" EXACT []
is_a: MP:0008755 ! abnormal immunoglobulin V(D)J recombination

[Term]
id: MP:0008762
name: embryonic lethality
def: "death of an animal within the embryonic period prior to organogenesis (Mus: prior to E14)" [https://orcid.org/0000-0003-3691-0324]
comment: Note that a term with the former name embryonic lethality exists as MP:0002080. In many species, the terms prenatal lethality and embryonic lethality are used interchangeably. However, this is not technically correct and we have modified this ontology to define the prenatal period to include the embryonic stages distinctly from the fetal stages. The names embryonic lethality and embryonic death have been retained as a narrow synonyms for the prenatal lethality term to aid in searching for those species that may use these terms as synonyms.
subset: IMPC_Prenatal
subset: Sanger_Terms
synonym: "embryonic death" EXACT []
is_a: MP:0013294 ! prenatal lethality prior to heart atrial septation

[Term]
id: MP:0008763
name: abnormal mast cell degranulation
def: "abnormalities in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal mast cell granule exocytosis" EXACT []
is_a: MP:0002423 ! abnormal mast cell physiology
is_a: MP:0020848 ! abnormal exocytosis

[Term]
id: MP:0008764
name: increased mast cell degranulation
def: "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, https://orcid.org/0000-0003-1980-3228]
synonym: "increased mast cell granule exocytosis" EXACT []
is_a: MP:0008763 ! abnormal mast cell degranulation

[Term]
id: MP:0008765
name: decreased mast cell degranulation
def: "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, https://orcid.org/0000-0003-1980-3228]
synonym: "decreased mast cell granule exocytosis" EXACT []
synonym: "reduced mast cell degranulation" EXACT []
synonym: "reduced mast cell granule exocytosis" EXACT []
is_a: MP:0008763 ! abnormal mast cell degranulation

[Term]
id: MP:0008766
name: abnormal B cell receptor editing
def: "any anomaly in the process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor" [GO:0002452, https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal B lymphocyte receptor editing" EXACT []
synonym: "abnormal B-cell receptor editing" EXACT []
synonym: "abnormal B-lymphocyte receptor editing" EXACT []
is_a: MP:0002144 ! abnormal B cell differentiation

[Term]
id: MP:0008767
name: abnormal hair medullary septa cells
def: "septa-forming cells of hair medulla are abnormal in size or arrangement" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0003812 ! abnormal hair medulla

[Term]
id: MP:0008768
name: abnormal hair medulla air spaces
def: "air spaces between septa-forming cells of hair medulla are larger or smaller than normal" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0003812 ! abnormal hair medulla

[Term]
id: MP:0008769
name: abnormal plasmacytoid dendritic cell physiology
def: "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002376 ! abnormal dendritic cell physiology

[Term]
id: MP:0008770
name: decreased survivor rate
def: "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2]
comment: This term is used in conjunction with other lethality terms when the lethality is only partially expressed. For example, use this term when some individuals of a defined population die as embryos, neonates or by weaning, with some percentage of individuals surviving the lethal phase and achieving a normal life span.
subset: Sanger_Terms
synonym: "decreased survival rate" EXACT []
synonym: "low survival rate" EXACT []
synonym: "low survivor rate" EXACT []
synonym: "reduced survival rate" EXACT []
synonym: "reduced survivor rate" EXACT []
synonym: "reduced viability" RELATED []
is_a: MP:0010831 ! lethality, incomplete penetrance

[Term]
id: MP:0008771
name: elongated vertebral column
def: "increased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [https://orcid.org/0000-0003-3691-0324, MGI:brs]
synonym: "elongated spinal axis" EXACT []
synonym: "elongated spinal column" EXACT []
synonym: "increased vertebral column length" EXACT []
synonym: "long spinal axis" EXACT []
synonym: "long spinal column" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology

[Term]
id: MP:0008772
name: increased heart ventricle size
def: "increased average size of one or both heart ventricles compared to the average for a particular population" [MGI:rbabiuk]
synonym: "enlarged heart ventricle" RELATED []
is_a: MP:0031543 ! abnormal heart ventricle size

[Term]
id: MP:0008775
name: abnormal heart ventricle pressure
def: "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
comment: Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., Doppler echocardiography). The information is useful in evaluating the function of the myocardium, cardiac valves and pericardium, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
synonym: "abnormal cardiac ventricular pressure" EXACT []
synonym: "abnormal heart intraventricular pressure" EXACT []
synonym: "abnormal heart ventricular pressure" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology

[Term]
id: MP:0008776
name: increased right ventricle peak pressure
def: "increase in the difference between right ventricular systolic and diastolic pressures" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased right ventricular peak pressure" EXACT []
synonym: "increased RVPP" EXACT []
synonym: "right ventricular pulse pressure" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure

[Term]
id: MP:0008777
name: increased right ventricle diastolic pressure
def: "increase in the pressure of the right ventricle between heart beats when the heart is relaxed" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased right ventricular diastolic pressure" EXACT []
synonym: "increased RVP" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure

[Term]
id: MP:0008778
name: abnormal lymphangiogenesis
def: "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
comment: Do not use for the initial specification of lymphatic vessels in early development; use for the remodeling of pre-existing lymphatic vessels. This term is similar to angiogenesis for blood vessel remodeling.
is_a: MP:0001879 ! abnormal lymphatic vessel morphology

[Term]
id: MP:0008779
name: abnormal maternal behavior
def: "any anomaly in any response from the mother or attending female related to the ability of young to thrive" [MGI:llw2]
synonym: "abnormal maternal behaviour" EXACT []
is_a: MP:0002068 ! abnormal parental behavior

[Term]
id: MP:0008780
name: increased pancreatic acinar cell carcinoma incidence
def: "greater than the expected number of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "acinar carcinoma" RELATED []
synonym: "increased pancreatic acinar cell adenocarcinoma incidence" EXACT []
synonym: "pancreatic ACC" RELATED []
synonym: "pancreatic acinar carcinoma" RELATED []
is_a: MP:0009153 ! increased pancreas tumor incidence
is_a: MP:0009308 ! increased adenocarcinoma incidence

[Term]
id: MP:0008781
name: abnormal B cell apoptosis
def: "change in the timing or the number of B cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal B lymphocyte apoptosis" EXACT []
synonym: "abnormal B-cell apoptosis" EXACT []
synonym: "abnormal B-lymphocyte apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002459 ! abnormal B cell physiology

[Term]
id: MP:0008782
name: increased B cell apoptosis
def: "increase in the timing or the number of B cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased B lymphocyte apoptosis" EXACT []
synonym: "increased B-cell apoptosis" EXACT []
synonym: "increased B-lymphocyte apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0008781 ! abnormal B cell apoptosis

[Term]
id: MP:0008783
name: decreased B cell apoptosis
def: "reduction in the timing or the number of B cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased B lymphocyte apoptosis" EXACT []
synonym: "decreased B-cell apoptosis" EXACT []
synonym: "decreased B-lymphocyte apoptosis" EXACT []
synonym: "reduced B lymphocyte apoptosis" EXACT []
synonym: "reduced B-cell apoptosis" EXACT []
synonym: "reduced B-lymphocyte apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0008781 ! abnormal B cell apoptosis

[Term]
id: MP:0008784
name: craniorachischisis
def: "the most severe form of neural tube defect leaving the neural tube open from the midbrain or rostral hindbrain to the base of the spine; in mammals, craniorachischisis arises as a failure of a de novo closure event occurring during primary neurulation at the boundary of the future hindbrain and cervical spine (day 22 postfertilization in humans and E8.5 in mice); craniorachischisis totalis, the most complete form of craniorachischisis, presents anencephaly and total spina bifida together and is lethal" [https://orcid.org/0000-0002-6490-7723]
synonym: "CRN" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0008785
name: abnormal sternum manubrium morphology
def: "any structural anomaly of the broad, handle-like part of the sternum which articulates with the clavicles and the first two pairs of ribs" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal manubrium of sternum morphology" EXACT []
synonym: "abnormal sternal manubrium morphology" EXACT []
synonym: "sternal manubrium dysplasia" NARROW []
is_a: MP:0000157 ! abnormal sternum morphology

[Term]
id: MP:0008786
name: abnormal hindgut morphology
def: "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2]
synonym: "hindgut dysplasia" RELATED []
is_a: MP:0003119 ! abnormal digestive system development

[Term]
id: MP:0008787
name: abnormal tailgut morphology
def: "any structural anomaly of the extension of the hindgut of the primitive digestive tube of the embryo, caudal to the location of the anal opening" [MGI:llw2]
synonym: "abnormal postanal gut morphology" EXACT []
is_a: MP:0003119 ! abnormal digestive system development

[Term]
id: MP:0008788
name: abnormal fetal cardiomyocyte morphology
def: "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
synonym: "abnormal cardiomyoblast morphology" EXACT []
synonym: "abnormal foetal cardiomyocyte morphology" EXACT []
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0008789
name: abnormal olfactory epithelium morphology
alt_id: MP:0006091
def: "any structural anomaly of the epithelial cells that line the interior of the nose" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal nasal epithelium morphology" EXACT []
synonym: "olfactory epithelium dysplasia" NARROW []
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0005499 ! abnormal olfactory system morphology
is_a: MP:0010942 ! abnormal respiratory epithelium morphology

[Term]
id: MP:0008790
name: abnormal NK cell degranulation
def: "anomaly in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs]
is_a: MP:0011719 ! abnormal natural killer cell mediated cytotoxicity
is_a: MP:0020848 ! abnormal exocytosis

[Term]
id: MP:0008791
name: decreased NK cell degranulation
def: "reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs]
synonym: "reduced NK cell degranulation" EXACT []
is_a: MP:0008790 ! abnormal NK cell degranulation

[Term]
id: MP:0008792
name: increased NK cell degranulation
def: "increase in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs]
is_a: MP:0008790 ! abnormal NK cell degranulation

[Term]
id: MP:0008793
name: abnormal lens epithelium apoptosis
def: "anomaly in the number of lens epithelial cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0008794
name: increased lens epithelium apoptosis
def: "increase in the number of lens epithelial cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0008793 ! abnormal lens epithelium apoptosis

[Term]
id: MP:0008795
name: abnormal lens fiber apoptosis
def: "anomaly in the number of lens fibers cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lens fibre apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0008796
name: increased lens fiber apoptosis
def: "increase in the number of lens fibers cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lens fibre apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0008795 ! abnormal lens fiber apoptosis

[Term]
id: MP:0008797
name: facial cleft
def: "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "prosopoanoschisis" EXACT []
synonym: "split face malformation" EXACT []
synonym: "split-face malformation" EXACT []
synonym: "Tessier Cleft" EXACT []
is_a: MP:0003743 ! abnormal facial morphology

[Term]
id: MP:0008798
name: lateral facial cleft
def: "presence of a primitive oral fissure (macrostomia) that extends into the anlage region of the ears, between the 1st and 2nd pharyngeal arches" [https://orcid.org/0000-0003-3691-0324]
synonym: "transverse facial cleft" EXACT []
is_a: MP:0008797 ! facial cleft

[Term]
id: MP:0008799
name: oblique facial cleft
def: "presence of a facial fissure that runs from the lower lid edge to the lower edge of the nasal opening that results from a deficient fusion of the epithelium of the lacrimonasal duct" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008797 ! facial cleft

[Term]
id: MP:0008800
name: increased small intestinal crypt cell apoptosis
def: "increase in the number of small intestinal crypt cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0010156 ! abnormal small intestinal crypt cell physiology

[Term]
id: MP:0008801
name: abnormal erythroid progenitor cell morphology
def: "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
synonym: "abnormal BFU-E morphology" RELATED []
synonym: "abnormal blast forming unit erythroid morphology" RELATED []
synonym: "abnormal burst forming unit erythroid morphology" RELATED []
synonym: "abnormal CFU-E morphology" RELATED []
synonym: "abnormal colony forming unit erythroid morphology" RELATED []
synonym: "abnormal erythroid stem cell morphology" EXACT []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013659 ! abnormal erythroid lineage cell morphology
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0008802
name: abnormal intestinal smooth muscle morphology
def: "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [https://orcid.org/0000-0003-3691-0324]
synonym: "intestinal smooth muscle dysplasia" NARROW []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0000767 ! abnormal smooth muscle morphology

[Term]
id: MP:0008803
name: abnormal placental labyrinth vasculature morphology
def: "any structural anomaly of blood vessels of the layer of the placenta where embryonic and maternal blood exchange nutrients and waste products" [https://orcid.org/0000-0003-4606-0597]
synonym: "placental labyrinth vasculature dysplasia" NARROW []
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
is_a: MP:0003231 ! abnormal placenta vasculature

[Term]
id: MP:0008804
name: abnormal circulating amylase level
def: "any anomaly in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8, MESH:D08.811.277.450.066]
synonym: "abnormal circulating diastase level" EXACT [MESH:D08.811.277.450.066]
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0008805
name: decreased circulating amylase level
def: "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8, MESH:D08.811.277.450.066, MGI:brs]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating diastase level" EXACT [MESH:D08.811.277.450.066]
synonym: "reduced circulating amylase level" EXACT []
is_a: MP:0008804 ! abnormal circulating amylase level
is_a: MP:0014451 ! decreased circulating enzyme level

[Term]
id: MP:0008806
name: increased circulating amylase level
def: "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8, MESH:D08.811.277.450.066]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased circulating diastase level" EXACT [MESH:D08.811.277.450.066]
is_a: MP:0008804 ! abnormal circulating amylase level
is_a: MP:0014450 ! increased circulating enzyme level

[Term]
id: MP:0008807
name: increased liver iron level
def: "increase in the amount of iron present in the liver tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased hepatic iron level" EXACT []
synonym: "increased hepatic iron load" EXACT []
synonym: "increased liver iron load" EXACT []
synonym: "liver iron deposits" EXACT []
is_a: MP:0008738 ! abnormal liver iron level

[Term]
id: MP:0008808
name: decreased spleen iron level
def: "reduction in the amount of iron present in the spleen tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased spleen iron load" EXACT []
synonym: "decreased splenic iron level" EXACT []
synonym: "reduced spleen iron level" RELATED []
synonym: "reduced splenic iron load" RELATED []
is_a: MP:0008739 ! abnormal spleen iron level
is_a: MP:0014542 ! decreased iron level

[Term]
id: MP:0008809
name: increased spleen iron level
def: "increase in the amount of iron present in the spleen tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased spleen iron load" EXACT []
synonym: "increased splenic iron level" EXACT []
synonym: "increased splenic iron load" EXACT []
synonym: "spleen iron deposits" EXACT []
is_a: MP:0008739 ! abnormal spleen iron level
is_a: MP:0014541 ! increased iron level

[Term]
id: MP:0008810
name: increased circulating iron level
def: "elevation in the concentration of iron in the blood" [https://orcid.org/0000-0003-4606-0597]
comment: Serum iron measures the total amount of iron in the blood, nearly all of which is bound to transferrin.
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyperferraemia" EXACT []
synonym: "hyperferremia" EXACT []
is_a: MP:0004152 ! abnormal circulating iron level
is_a: MP:0014541 ! increased iron level
is_a: MP:0014547 ! increased circulating mineral level

[Term]
id: MP:0008811
name: abnormal brain iron level
def: "any anomaly in the amount of iron present in the brain tissue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0008812
name: abnormal rostrocaudal coat patterning
def: "irregular or unusual pigmentation pattern of the rostral-to-caudal axis compared to control animals" [MGI:brs]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0008813
name: decreased common myeloid progenitor cell number
def: "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2]
synonym: "decreased CFU-S" RELATED []
synonym: "decreased CMPs" RELATED []
synonym: "decreased multipotential myeloid stem cell number" RELATED []
synonym: "decreased myeloid stem cell number" RELATED []
synonym: "decreased pluripotent stem cell (bone marrow) number" RELATED []
synonym: "reduced cfu-gemm number" EXACT []
synonym: "reduced common myeloid progenitor cell number" EXACT []
is_a: MP:0006410 ! abnormal common myeloid progenitor cell morphology

[Term]
id: MP:0008814
name: decreased nerve conduction velocity
def: "decrease in the rate at which an electrical impulse travels through a nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced nerve conduction velocity" EXACT []
synonym: "slowed nerve conduction" EXACT []
is_a: MP:0005403 ! abnormal nerve conduction

[Term]
id: MP:0008815
name: anterior staphyloma
def: "any structural anomaly resulting in bulging near the anterior pole of the eyeball" [MGI:llw2]
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0008816
name: petechiae
def: "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0008817
name: hematoma
def: "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2]
synonym: "haematoma" EXACT []
is_a: MP:0002128 ! abnormal blood circulation

[Term]
id: MP:0008818
name: abnormal interfrontal bone morphology
def: "any structural anomaly or presence of a bone between the frontal bones in the skull; an extra bony plate within the anterior fontanelle that is not usually present" [https://orcid.org/0000-0003-3691-0324]
synonym: "interfrontal bone dysplasia" NARROW []
is_a: MP:0000074 ! abnormal neurocranium morphology
is_a: MP:0005274 ! abnormal viscerocranium morphology

[Term]
id: MP:0008819
name: abnormal mastication
def: "any anomaly in the process of biting and mashing food with the teeth prior to swallowing" [MGI:mberry]
synonym: "abnormal chewing" EXACT []
is_a: MP:0001431 ! abnormal eating behavior

[Term]
id: MP:0008820
name: abnormal blood uric acid level
def: "aberrant concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs]
synonym: "abnormal blood urate level" RELATED []
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0008821
name: increased blood uric acid level
def: "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "hyperuricaemia" EXACT []
synonym: "hyperuricemia" EXACT []
synonym: "increased blood urate level" RELATED []
is_a: MP:0008820 ! abnormal blood uric acid level

[Term]
id: MP:0008822
name: decreased blood uric acid level
def: "reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased blood urate level" RELATED []
synonym: "hypouricaemia" EXACT []
synonym: "hypouricemia" EXACT []
synonym: "reduced blood uric acid level" EXACT []
is_a: MP:0008820 ! abnormal blood uric acid level

[Term]
id: MP:0008823
name: abnormal interventricular septum membranous part morphology
def: "any structural anomaly of the membranous portion of the wall between the two lower chambers of the heart" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal ventricular membranous septum morphology" EXACT []
is_a: MP:0000281 ! abnormal interventricular septum morphology

[Term]
id: MP:0008824
name: absent interventricular septum membranous part
def: "absence of the membranous portion of the wall between the two lower chambers of the heart" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent ventricular membranous septum" EXACT []
is_a: MP:0008823 ! abnormal interventricular septum membranous part morphology

[Term]
id: MP:0008825
name: abnormal cardiac epithelial to mesenchymal transition
def: "anomaly in the process by which endocardial cells of the atrioventricular canal or the outflow tract lose their epithelial characteristics, delaminate from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventually forming both the endocardial cushions required for septum and atrioventricular valve formation and the cushions of the outflow tract that form the conotruncal septum" [PMID:17303760]
synonym: "abnormal cardiac epithelial to mesenchymal transformation" EXACT []
synonym: "abnormal endocardial-mesenchymal transformation" EXACT []
is_a: MP:0002925 ! abnormal cardiovascular development

[Term]
id: MP:0008826
name: abnormal splenic cell ratio
def: "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry]
synonym: "abnormal spleen cell ratio" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0008827
name: abnormal thymus cell ratio
def: "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry]
synonym: "abnormal thymic cell ratio" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0008828
name: abnormal lymph node cell ratio
def: "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry]
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0008829
name: triphalangia
def: "anomaly in which three phalanges are present in the thumb or great toe" [ISBN:0-683-40008-8]
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0008830
name: abnormal nucleolus morphology
def: "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8]
synonym: "abnormal nucleolar morphology" EXACT []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008831
name: abnormal insulin-like growth factor I level
def: "anomaly in the concentration of a polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry]
synonym: "abnormal IGF-I level" EXACT []
synonym: "abnormal IGF1 level" EXACT []
is_a: MP:0003953 ! abnormal hormone level

[Term]
id: MP:0008832
name: hemivertebra
def: "a congenital malformation of the spine in which only half of a vertebral body develops" [ISBN:0-683-40008-8]
synonym: "hemi-vertebra" EXACT []
synonym: "hemi-vertebrae" EXACT []
synonym: "hemivertebrae" EXACT []
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0008833
name: caudal hemivertebra
def: "a congenital malformation of the caudal vertebrae in which only half of the vertebral body develops" [ISBN:0-683-40008-8]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0008832 ! hemivertebra

[Term]
id: MP:0008834
name: abnormal melanosome transport
def: "any anomaly in the directed movement of melanosomes into, out of, within or between cells" [GO:0032402]
synonym: "abnormal melanin granule transport" NARROW []
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0008835
name: abnormal intercellular signaling peptide or protein level
def: "abnormal concentration of any regulatory protein or peptide that is a signaling molecule involved in the process of paracrine communication" [MESH:D12.644.276]
comment: These molecules are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. These are distinguished from hormones in that their actions are local rather than distal.
synonym: "abnormal growth factor level" EXACT []
synonym: "abnormal paracrine peptide factor level" EXACT []
synonym: "abnormal paracrine protein factor level" EXACT []
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0008836
name: abnormal transforming growth factor beta level
def: "abnormal concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
comment: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. (MESH:D12.644.276.374.687).
synonym: "abnormal bone-derived transforming growth factor level" EXACT []
synonym: "abnormal milk growth factor level" EXACT []
synonym: "abnormal platelet transforming growth factor level" EXACT []
synonym: "abnormal TGF-beta level" EXACT []
synonym: "abnormal TGFbeta level" EXACT []
is_a: MP:0008835 ! abnormal intercellular signaling peptide or protein level

[Term]
id: MP:0008837
name: increased transforming growth factor beta level
def: "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
comment: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. (MESH:D12.644.276.374.687).
synonym: "increased bone-derived transforming growth factor level" EXACT []
synonym: "increased milk growth factor level" EXACT []
synonym: "increased platelet transforming growth factor level" EXACT []
synonym: "increased TGF-beta level" EXACT []
synonym: "increased TGFbeta level" EXACT []
is_a: MP:0008836 ! abnormal transforming growth factor beta level

[Term]
id: MP:0008838
name: decreased transforming growth factor beta level
def: "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
comment: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. (MESH:D12.644.276.374.687).
synonym: "decreased bone-derived transforming growth factor level" EXACT []
synonym: "decreased milk growth factor level" EXACT []
synonym: "decreased platelet transforming growth factor level" EXACT []
synonym: "decreased TGF-beta level" EXACT []
synonym: "decreased TGFbeta level" EXACT []
synonym: "reduced bone-derived transforming growth factor level" EXACT []
synonym: "reduced milk growth factor level" EXACT []
synonym: "reduced platelet transforming growth factor level" EXACT []
synonym: "reduced TGF-beta level" EXACT []
synonym: "reduced TGFbeta level" EXACT []
is_a: MP:0008836 ! abnormal transforming growth factor beta level

[Term]
id: MP:0008839
name: absent acrosome
def: "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2]
synonym: "absent acrosomal granule" EXACT []
synonym: "absent acrosomal vesicle" EXACT []
is_a: MP:0008898 ! abnormal acrosome morphology

[Term]
id: MP:0008840
name: abnormal spike wave discharge
def: "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
synonym: "abnormal spike and wave discharge" EXACT []
synonym: "abnormal spike-and-wave discharge" EXACT []
synonym: "abnormal spike-wave discharge" EXACT []
synonym: "abnormal SWDs" EXACT []
is_a: MP:0003216 ! absence seizures

[Term]
id: MP:0008841
name: ruptured lens capsule
def: "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2]
is_a: MP:0003236 ! abnormal lens capsule morphology

[Term]
id: MP:0008842
name: lipofuscinosis
def: "accumulation of intracellular autofluorescent material, in the form of brownish fatty pigment, in lysosomes as a normal part of senescence or aging" [PMID:16455164]
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0008843
name: absent subcutaneous adipose tissue
def: "absence of adipose tissue beneath the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent hypodermal fat layer" EXACT []
synonym: "absent panniculus adiposus" EXACT []
synonym: "absent subcutaneous fat layer" EXACT []
is_a: MP:0020997 ! abnormal subcutaneous adipose tissue amount

[Term]
id: MP:0008844
name: decreased subcutaneous adipose tissue amount
def: "reduction in amount of adipose tissue beneath the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced subcutaneous adipose tissue amount" EXACT []
is_a: MP:0020997 ! abnormal subcutaneous adipose tissue amount

[Term]
id: MP:0008845
name: abnormal paraventricular hypothalamic nucleus morphology
def: "any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8]
synonym: "abnormal hypothalamic paraventricular nucleus morphology" EXACT []
synonym: "abnormal paraventricular nucleus morphology" EXACT []
synonym: "paraventricular hypothalamic nucleus dysplasia" NARROW []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology

[Term]
id: MP:0008846
name: abnormal supraoptic nucleus morphology
def: "any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8]
synonym: "supraoptic nucleus dysplasia" NARROW []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology

[Term]
id: MP:0008847
name: abnormal suprachiasmatic nucleus morphology
def: "any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8, MESH:A08.186.211.730.317.357.342.625]
synonym: "suprachiasmatic nucleus dysplasia" NARROW []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology

[Term]
id: MP:0008848
name: abnormal anterior hypothalamic nucleus morphology
def: "any structural anomaly of a loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral preoptic areas and caudally with the tuber cinereum" [MESH:A08.186.211.730.317.357.342.063]
synonym: "abnormal anterior hypothalamic area morphology" EXACT []
synonym: "anterior hypothalamic nucleus dysplasia" NARROW []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology

[Term]
id: MP:0008849
name: abnormal hemoglobin concentration distribution width
def: "anomaly in the standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations" [MGI:brs]
synonym: "abnormal haemoglobin concentration distribution width" EXACT []
synonym: "abnormal HDW" EXACT []
is_a: MP:0005563 ! abnormal hemoglobin content

[Term]
id: MP:0008850
name: increased hemoglobin concentration distribution width
def: "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs]
synonym: "increased haemoglobin concentration distribution width" EXACT []
synonym: "increased HDW" EXACT []
is_a: MP:0008849 ! abnormal hemoglobin concentration distribution width

[Term]
id: MP:0008851
name: decreased hemoglobin concentration distribution width
def: "lower than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations" [MGI:brs]
synonym: "decreased haemoglobin concentration distribution width" EXACT []
synonym: "decreased HDW" EXACT []
is_a: MP:0008849 ! abnormal hemoglobin concentration distribution width

[Term]
id: MP:0008852
name: retina neovascularization
def: "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
synonym: "retinal neovascularization" EXACT []
is_a: MP:0002792 ! abnormal retina vasculature morphology
is_a: MP:0003711 ! pathological neovascularization

[Term]
id: MP:0008853
name: decreased abdominal adipose tissue amount
def: "reduction in amount of adipose tissue associated with internal organs" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced abdominal adipose tissue amount" EXACT []
is_a: MP:0005452 ! abnormal adipose tissue amount

[Term]
id: MP:0008854
name: bleb
def: "presence of a blister-like, nearly hemispherical structure filled with air, serous fluid or blood" [MGI:llw2]
synonym: "blistering" BROAD []
synonym: "bulla" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0008855
name: eye bleb
def: "presence of blister-like structures formed in the eye during embryonic development that are usually filled with blood" [MGI:llw2]
is_a: MP:0001286 ! abnormal eye development

[Term]
id: MP:0008856
name: fetal bleb
def: "presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood" [MGI:llw2]
synonym: "foetal bleb" EXACT []
is_a: MP:0003941 ! abnormal skin development

[Term]
id: MP:0008857
name: myelencephalic blebs
def: "presence of blister-like structures formed on the posterior portion of the embryonic hindbrain that are usually filled with blood" [MGI:llw2]
is_a: MP:0006108 ! abnormal hindbrain development

[Term]
id: MP:0008858
name: abnormal hair cycle anagen phase
def: "anomaly in the growth phase of the hair cycle" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0008859
name: abnormal hair cycle catagen phase
def: "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0008860
name: abnormal hair cycle telogen phase
def: "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and precedes hair loss" [MGI:llw2]
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0008861
name: abnormal hair shedding
def: "anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000427 ! abnormal hair cycle

[Term]
id: MP:0008862
name: asymmetric snout
def: "presence of a snout that lacks mirrored identity on either side of the median plane" [MGI:mberry]
subset: IMPC
subset: Sanger_Terms
synonym: "snout asymmetry" EXACT []
is_a: MP:0000443 ! abnormal snout morphology

[Term]
id: MP:0008863
name: craniofacial asymmetry
def: "head or facial features that lack mirrored identity on either side of the median plane" [MGI:mberry]
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0008864
name: abnormal intestinal secretion
def: "any anomaly in the quantity or rate of any substance transported from intestinal cells into the lumen of the intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000501 ! abnormal digestive secretion

[Term]
id: MP:0008866
name: chromosomal instability
def: "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2, PMID:12446840]
subset: IMPC
subset: Sanger_Terms
synonym: "genomic instability" RELATED []
is_a: MP:0010094 ! abnormal chromosome stability

[Term]
id: MP:0008867
name: uniparental disomy
def: "abnormal assortment of chromosomes from parent to offspring whereby the chromosome number is correct, but both members of a chromosome pair or segments of a chromosome pair are inherited from the same parent" [MGI:llw2]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0008868
name: abnormal granulosa cell morphology
def: "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
synonym: "granulosa cell dysplasia" NARROW []
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0008869
name: anovulation
def: "complete failure of ovum to be released from an ovarian follicle" [https://orcid.org/0000-0003-0431-8641, MESH:C13.351.500.056.630.050]
synonym: "absence of ovulation" EXACT []
synonym: "absent ovulation" EXACT []
is_a: MP:0001928 ! abnormal ovulation

[Term]
id: MP:0008870
name: increased mature ovarian follicle number
def: "than normal numbers of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0009364 ! abnormal mature ovarian follicle morphology

[Term]
id: MP:0008871
name: abnormal ovarian follicle number
def: "abnormal numbers of spheroid cell aggregations in the ovary" [https://orcid.org/0000-0003-0431-8641]
synonym: "abnormal growing ovarian follicle number" NARROW []
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0008872
name: abnormal physiological response to xenobiotic
def: "any anomaly in the physiological or morphological changes induced by a compound foreign to living organisms  such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal physiological response to xenobiotics" EXACT []
synonym: "abnormal response to xenobiotics" RELATED []
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0008873
name: increased physiological sensitivity to xenobiotic
def: "decrease in the dose or concentration of a compound foreign to living organisms required to induce a specific level of physiological response  or increase in the severity of physiological response to a given dose or concentration of a compound foreign  to living organisms" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to xenobiotics" EXACT []
synonym: "increased physiological sensitivity to xenobiotics" EXACT []
synonym: "increased susceptibility to xenobiotics" EXACT []
is_a: MP:0008872 ! abnormal physiological response to xenobiotic

[Term]
id: MP:0008874
name: decreased physiological sensitivity to xenobiotic
def: "increase in the dose or concentration of a compound foreign to living organisms required to induce a specific level of physiological response or decrease in the severity of physiological response to a given dose or concentration of a compound foreign  to living organisms" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased physiological sensitivity to xenobiotics" EXACT []
synonym: "decreased susceptibility to xenobiotics" EXACT []
synonym: "increased resistance to xenobiotics" EXACT []
is_a: MP:0008872 ! abnormal physiological response to xenobiotic

[Term]
id: MP:0008875
name: abnormal xenobiotic pharmacokinetics
def: "any anomaly in the absorption, distribution, metabolism or elimination of a compound foreign to living organisms" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal pharmacokinetics of xenobiotics" EXACT []
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0008876
name: decreased uterine NK cell number
def: "reduced cell number of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy" [PMID:14568979, PMID:19800965]
synonym: "decreased decidual natural killer cell number" EXACT []
synonym: "decreased decidual NK cell number" EXACT []
synonym: "decreased dNK cell number" EXACT []
synonym: "decreased GMG cell number" EXACT []
synonym: "decreased granulated metrial gland cell number" EXACT []
synonym: "decreased uNK cell number" EXACT []
synonym: "decreased uterine natural killer cell number" EXACT []
synonym: "reduced decidual natural killer cell number" EXACT []
synonym: "reduced decidual NK cell number" EXACT []
synonym: "reduced dNK cell number" EXACT []
synonym: "reduced GMG cell number" EXACT []
synonym: "reduced granulated metrial gland cell number" EXACT []
synonym: "reduced uNK cell number" EXACT []
synonym: "reduced uterine natural killer cell number" EXACT []
xref: CL:0002343
is_a: MP:0008045 ! decreased NK cell number
is_a: MP:0008054 ! abnormal uterine NK cell morphology

[Term]
id: MP:0008877
name: abnormal DNA methylation
def: "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
is_a: MP:0012167 ! abnormal epigenetic regulation of gene expression

[Term]
id: MP:0008878
name: abnormal DNA methylation during gametogenesis
def: "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
synonym: "abnormal de novo DNA methylation" EXACT []
is_a: MP:0001929 ! abnormal gametogenesis
is_a: MP:0008877 ! abnormal DNA methylation

[Term]
id: MP:0008879
name: submandibular gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0003-3691-0324]
synonym: "submaxillary gland inflammation" EXACT []
is_a: MP:0001870 ! salivary gland inflammation
is_a: MP:0013300 ! abnormal submandibular gland physiology

[Term]
id: MP:0008880
name: lacrimal gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [https://orcid.org/0000-0003-3691-0324]
synonym: "dacryoadenitis" EXACT []
is_a: MP:0001348 ! abnormal lacrimal gland physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0008881
name: absent Harderian gland
def: "absence of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane" [ISBN:0486631850]
comment: The Harderian gland does not normally exist in some types of mammals (bats, cows and horses), terrestrial carnivores, and higher primates including human.
is_a: MP:0005248 ! abnormal Harderian gland morphology

[Term]
id: MP:0008882
name: abnormal enterocyte physiology
def: "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intestinal cell physiology" EXACT []
synonym: "abnormal intestinal epithelial cell physiology" EXACT []
is_a: MP:0014201 ! abnormal intestinal epithelium physiology

[Term]
id: MP:0008883
name: abnormal enterocyte proliferation
def: "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intestinal cell proliferation" EXACT []
synonym: "abnormal intestinal epithelial cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0008882 ! abnormal enterocyte physiology

[Term]
id: MP:0008884
name: abnormal enterocyte apoptosis
def: "change in the timing or the number of enterocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intestinal epithelial cell apoptosis" EXACT []
is_a: MP:0008882 ! abnormal enterocyte physiology
is_a: MP:0020444 ! abnormal intestine apoptosis

[Term]
id: MP:0008885
name: increased enterocyte apoptosis
def: "increase in the timing or the number of enterocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased intestinal cell apoptosis" EXACT []
synonym: "increased intestinal epithelial cell apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0008884 ! abnormal enterocyte apoptosis

[Term]
id: MP:0008886
name: abnormal PML bodies
def: "alteration in structure, number or location of the subnuclear structures associated with functions including transcription, DNA repair, viral defense, stress, cell cycle regulation, proteolysis and apoptosis" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2]
synonym: "abnormal Kr bodies" EXACT []
synonym: "abnormal ND10 morphology" EXACT []
synonym: "abnormal nuclear dot morphology" EXACT []
synonym: "abnormal PML NBs" EXACT []
synonym: "abnormal Promyelocytic leukaemia nuclear body" EXACT []
synonym: "abnormal SP-100 bodies" EXACT []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008887
name: abnormal splicing factor domain morphology
def: "alteration in structure, number or location of subnuclear structures comprising storage locations for elements responsible for excising non-coding regions from a primary messenger RNA transcript and joining coding regions to produce mature messenger RNA" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2]
comment: Same as nuclear speck (GO0016607)?
synonym: "abnormal splicing speckle morphology" EXACT []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008888
name: abnormal Cajal body morphology
def: "alteration in structure, number or location of subnuclear structures involved in snRNP biogenesis and in the trafficking of snoRNPs and snRNPs" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2]
synonym: "abnormal coiled body morphology" EXACT []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008889
name: abnormal Gem morphology
def: "alteration in structure, number or location of subnuclear structures involved in snRNP biogenesis and in the trafficking of snoRNPs and snRNPs and found paired with or juxtaposed to Cajal bodies" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2]
synonym: "abnormal SMN gem morphology" EXACT []
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008890
name: abnormal nuclear lamina morphology
def: "any structural anomaly of the inner nuclear membrane surrounding the nuclear periphery, comprising a scaffold-like network of protein filaments responsible for trafficking of mRNA to the cytoplasm" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2]
is_a: MP:0003111 ! abnormal cell nucleus morphology

[Term]
id: MP:0008891
name: decreased hepatocyte apoptosis
def: "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk]
synonym: "reduced hepatocyte apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0010080 ! abnormal hepatocyte physiology

[Term]
id: MP:0008892
name: abnormal sperm flagellum morphology
def: "any structural anomaly of the whiplike posterior filiform portion of the spermatozoon composed of a number of cytoskeletal elements whose proper assembly is critical for sperm motility; the mammalian flagellum is structurally divided into four major parts: the connecting piece, the midpiece, the principal piece, and the end piece" [MESH:A05.360.490.890.840, PMID:14581499]
synonym: "abnormal sperm flagella" EXACT []
synonym: "abnormal sperm tail" EXACT [MESH:A05.360.490.890.840]
is_a: MP:0005578 ! teratozoospermia
is_a: MP:0013206 ! abnormal motile cilium morphology

[Term]
id: MP:0008893
name: detached sperm flagellum
def: "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [https://orcid.org/0000-0003-3691-0324, MESH:A05.360.490.890.840]
synonym: "detached sperm flagella" EXACT []
synonym: "detached sperm tail" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0008894
name: abnormal intraepithelial T cell morphology
def: "any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
synonym: "abnormal IEL morphology" EXACT []
synonym: "abnormal intraepithelial lymphocyte morphology" EXACT []
synonym: "abnormal intraepithelial T lymphocyte morphology" EXACT []
synonym: "abnormal intraepithelial T-cell morphology" EXACT []
synonym: "abnormal intraepithelial T-lymphocyte morphology" EXACT []
is_a: MP:0008037 ! abnormal T cell morphology

[Term]
id: MP:0008895
name: abnormal intraepithelial T cell number
def: "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
synonym: "abnormal IEL number" EXACT []
synonym: "abnormal intraepithelial lymphocyte number" EXACT []
synonym: "abnormal intraepithelial T lymphocyte number" RELATED []
synonym: "abnormal intraepithelial T-cell number" EXACT []
synonym: "abnormal intraepithelial T-lymphocyte number" EXACT []
is_a: MP:0006387 ! abnormal T cell number
is_a: MP:0008894 ! abnormal intraepithelial T cell morphology

[Term]
id: MP:0008896
name: increased IgG2c level
def: "greater than normal immunoglobulin class G2c level" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased serum level of immunoglobulin G2c" EXACT []
is_a: MP:0013803 ! increased IgG2 level
is_a: MP:0020178 ! abnormal IgG2c level

[Term]
id: MP:0008897
name: decreased IgG2c level
def: "less than normal immunoglobulin class G2c level" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased serum level of immunoglobulin G2c" EXACT []
synonym: "reduced IgG2c level" EXACT []
is_a: MP:0013804 ! decreased IgG2 level
is_a: MP:0020178 ! abnormal IgG2c level

[Term]
id: MP:0008898
name: abnormal acrosome morphology
def: "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
synonym: "abnormal acrosomal granule morphology" EXACT []
synonym: "abnormal acrosomal vesicle morphology" EXACT []
synonym: "acrosome dysplasia" NARROW []
is_a: MP:0009230 ! abnormal sperm head morphology

[Term]
id: MP:0008899
name: plush coat
def: "coat has a thick, velvet-like appearance" [MGI:brs]
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0008900
name: abnormal uterine fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the uterus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal periuterine fat pad morphology" EXACT []
synonym: "abnormal uterine fat depot morphology" EXACT []
synonym: "uterine fat pad dysplasia" NARROW []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0008901
name: absent epididymal fat pad
def: "absence of the encapsulated adipose tissue associated with the epididymis" [https://orcid.org/0000-0003-4606-0597, MGI:rbabiuk]
synonym: "absent periepididymal fat pad" EXACT []
is_a: MP:0005452 ! abnormal adipose tissue amount
is_a: MP:0006319 ! abnormal epididymal fat pad morphology

[Term]
id: MP:0008902
name: abnormal renal fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the kidney" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal adipose capsule of kidney morphology" EXACT []
synonym: "abnormal fatty capsule of kidney morphology" RELATED []
synonym: "abnormal perirenal fat capsule morphology" EXACT []
synonym: "abnormal perirenal fat morphology" EXACT []
synonym: "abnormal perirenal fat pad morphology" EXACT []
synonym: "abnormal renal fat depot morphology" RELATED []
synonym: "renal fat pad dysplasia" NARROW []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0008903
name: abnormal mesenteric fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the mesentery" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mesenteric fat depot morphology" EXACT []
synonym: "mesenteric fat pad dysplasia" NARROW []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0008904
name: abnormal mammary fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mammary fat depot morphology" RELATED []
synonym: "mammary fat pad dysplasia" NARROW []
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0008905
name: abnormal femoral fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal femoral fat depot morphology" EXACT []
synonym: "femoral fat pad dysplasia" NARROW []
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0008906
name: abnormal parametrial fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament" [ISBN:978-0-7020-2972-1]
synonym: "abnormal parametrial fat depot morphology" EXACT []
synonym: "parametrial fat pad dysplasia" NARROW []
is_a: MP:0008900 ! abnormal uterine fat pad morphology

[Term]
id: MP:0008907
name: decreased total fat pad weight
def: "less than average weight of the fat pads" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased total fat body weight" EXACT []
is_a: MP:0020130 ! abnormal total fat pad weight

[Term]
id: MP:0008908
name: increased total fat pad weight
def: "greater than average weight of the fat pads" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased total fat body weight" EXACT []
is_a: MP:0020130 ! abnormal total fat pad weight

[Term]
id: MP:0008909
name: supination
def: "rotation of the pedal or prehensile extremity so the forefoot (hand) faces anteriorly to the anatomic position; rotation of the hindfoot (foot) such that the plantar surface turns upward" [MGI:llw2]
is_a: MP:0014320 ! abnormal autopod rotation

[Term]
id: MP:0008910
name: thin long bone epiphysis
def: "thinner than normal rounded end of a long bone" [MGI:llw2]
is_a: MP:0000131 ! abnormal long bone epiphysis morphology

[Term]
id: MP:0008911
name: induced hyperactivity
def: "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC
is_a: MP:0001399 ! hyperactivity

[Term]
id: MP:0008912
name: nervous
def: "increased, skittish, behavior induced by stimulation such as handling, touching or noise" [MGI:llw2]
synonym: "easily agitated" EXACT []
synonym: "skittish" EXACT []
is_a: MP:0008911 ! induced hyperactivity

[Term]
id: MP:0008913
name: weaving
def: "momentary, slow motions of the whole body from side to side sometimes followed by a sudden drop from an erect position" [MGI:llw2]
synonym: "listing" EXACT []
synonym: "swaying" EXACT []
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0008914
name: enlarged cerebellum
def: "increased size of the cerebellum" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cerebellum size" EXACT []
is_a: MP:0000849 ! abnormal cerebellum morphology

[Term]
id: MP:0008915
name: fused carpal bones
def: "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "carpal bone fusion" EXACT []
is_a: MP:0000554 ! abnormal carpal bone morphology

[Term]
id: MP:0008916
name: abnormal astrocyte physiology
def: "any functional anomaly of one of the large neuroglia cells of nervous tissue" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal astroglia physiology" EXACT []
synonym: "abnormal astroglial cell physiology" EXACT []
is_a: MP:0003690 ! abnormal glial cell physiology

[Term]
id: MP:0008917
name: abnormal oligodendrocyte physiology
def: "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
synonym: "abnormal oligodendroglia physiology" EXACT []
synonym: "abnormal oligodendroglial cell physiology" EXACT []
synonym: "abnormal oligoglia physiology" RELATED []
synonym: "abnormal oligoglial cell physiology" EXACT []
is_a: MP:0003690 ! abnormal glial cell physiology

[Term]
id: MP:0008918
name: microgliosis
def: "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000136 ! abnormal microglial cell morphology
is_a: MP:0002183 ! gliosis

[Term]
id: MP:0008919
name: fused tarsal bones
def: "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8]
synonym: "fused tarsus bones" EXACT []
synonym: "fusion of tarsal bones" EXACT []
synonym: "tarsal bone fusion" EXACT []
is_a: MP:0005104 ! abnormal tarsal bone morphology

[Term]
id: MP:0008920
name: absent cervical axis
def: "absence of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent C2 vertebra" EXACT []
synonym: "absent epistropheus" EXACT []
is_a: MP:0004608 ! abnormal cervical axis morphology

[Term]
id: MP:0008921
name: increased neurotransmitter release
def: "increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005445 ! abnormal neurotransmitter secretion

[Term]
id: MP:0008922
name: abnormal cervical rib
def: "alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2]
is_a: MP:0000150 ! abnormal rib morphology

[Term]
id: MP:0008923
name: thoracoschisis
def: "congenital fissure of the chest wall" [MGI:llw2]
is_a: MP:0003385 ! abnormal body wall morphology

[Term]
id: MP:0008924
name: decreased cerebellar granule cell number
def: "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343]
synonym: "decreased granule cell number" BROAD []
synonym: "decreased granule neuron number" BROAD []
synonym: "reduced granule neuron number" BROAD []
xref: CL:0001031
is_a: MP:0004098 ! abnormal cerebellar granule cell morphology
is_a: MP:0008948 ! decreased neuron number

[Term]
id: MP:0008925
name: increased cerebellar granule cell number
def: "greater number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343]
synonym: "increased granule cell number" BROAD []
synonym: "increased granule neuron number" BROAD []
xref: CL:0001031
is_a: MP:0004098 ! abnormal cerebellar granule cell morphology
is_a: MP:0008947 ! increased neuron number

[Term]
id: MP:0008926
name: abnormal anterior definitive endoderm morphology
def: "any structural anomaly of the mesendoderm which first migrates from the node and evolves into the foregut, from which pancreas, liver and lungs will eventually emerge" [ISBN:9780080555959, PMID:12464432]
synonym: "abnormal ADE" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0008927
name: abnormal parafascicular nucleus morphology
def: "any structural anomaly in the thalmic nucleus that send excitatory projections onto striatal medium spiny neurons and cholinergic interneurons" [PMID:20980596]
synonym: "abnormal PFN morphology" EXACT []
synonym: "parafascicular nucleus dysplasia" NARROW []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0008928
name: abnormal paracentral nucleus morphology
def: "any structural anomaly of one of the intralaminar nuclei of the thalamus, located medial to the central lateral nucleus" [ISBN:0-683-40008-8]
synonym: "paracentral nucleus dysplasia" NARROW []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0008929
name: abnormal central medial nucleus morphology
def: "any structural anomaly of a small cell group in the interthalamic adhesion of the thalamus that occupy the midline region of the internal medullary lamina, between the left and right paracentral nuclei" [ISBN:0-683-40008-8]
synonym: "abnormal centromedian nucleus morphology" EXACT []
synonym: "abnormal medial central nucleus of thalamus" BROAD []
synonym: "central medial nucleus dysplasia" NARROW []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0008930
name: abnormal medial geniculate nucleus morphology
def: "any structural anomaly of groups of nerve cells that function as a relay of auditory input to auditory cortex, receiving the brachium of the inferior colliculus and sending processed information to the auditory cortex in the superior temporal gyrus" [ISBN:0-683-40008-8]
synonym: "abnormal MGN" RELATED []
synonym: "abnormal nucleus of medial geniculate body" EXACT []
synonym: "medial geniculate nucleus dysplasia" NARROW []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0008931
name: abnormal paraventricular thalamic nucleus morphology
def: "any structural anomaly in the nucleus in the thalamus that consists primarily of excitatory neurons, extends over the entire rostro-caudal length of the midline thalamus, and regulates arousal, emotional, and motivated behaviors" [PMID:33775435]
synonym: "paraventricular thalamic nucleus dysplasia" NARROW []
is_a: MP:0000832 ! abnormal thalamus morphology

[Term]
id: MP:0008932
name: abnormal embryonic tissue physiology
def: "any functional anomaly in any of the tissues of the embryo proper" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005380 ! embryo phenotype

[Term]
id: MP:0008933
name: abnormal motile primary cilium physiology
def: "any functional anomaly of the cilia of the mouse embryo found on the cells of the embryonic node, which generate flow of extraembryonic fluid surrounding the node in a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization" [GO:0031512, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal embryonic cilia physiology" EXACT []
synonym: "abnormal embryonic ciliary physiology" EXACT []
synonym: "abnormal embryonic cilium physiology" BROAD []
synonym: "abnormal motile primary cilia physiology" EXACT []
synonym: "abnormal nodal cilium physiology" EXACT []
is_a: MP:0008932 ! abnormal embryonic tissue physiology
is_a: MP:0013209 ! abnormal motile cilium physiology
is_a: MP:0013210 ! abnormal primary cilium physiology

[Term]
id: MP:0008934
name: absent choroid plexus
def: "absence of the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain" [http://medical-dictionary.thefreedictionary.com/plexus, https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0000820 ! abnormal choroid plexus morphology

[Term]
id: MP:0008935
name: decreased mean platelet volume
def: "reduced average content of platelet cells over normal" [MGI:mberry]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased MPV" EXACT []
synonym: "decreased platelet size" BROAD []
synonym: "reduced mean platelet volume" EXACT []
synonym: "reduced MPV" EXACT []
synonym: "reduced platelet size" BROAD []
synonym: "small platelet size" BROAD [HP:0005537]
synonym: "small platelets" BROAD [HP:0005537]
is_a: MP:0002586 ! abnormal platelet volume

[Term]
id: MP:0008936
name: abnormal pituitary gland size
def: "anomaly in the average size of the compound gland suspended from the base of the hypothalamus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000633 ! abnormal pituitary gland morphology

[Term]
id: MP:0008937
name: abnormal pituitary gland weight
def: "anomaly in the average weight of the compound gland suspended from the base of the hypothalamus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pituitary weight" EXACT []
is_a: MP:0008936 ! abnormal pituitary gland size

[Term]
id: MP:0008938
name: decreased pituitary gland weight
def: "reduction in the average weight of the compound gland suspended from the base of the hypothalamus" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced pituitary gland weight" EXACT []
synonym: "reduced pituitary weight" EXACT []
is_a: MP:0005361 ! small pituitary gland
is_a: MP:0008937 ! abnormal pituitary gland weight

[Term]
id: MP:0008939
name: increased pituitary gland weight
def: "greater than average weight of the compound gland suspended from the base of the hypothalamus" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased pituitary weight" EXACT []
is_a: MP:0000636 ! enlarged pituitary gland
is_a: MP:0008937 ! abnormal pituitary gland weight

[Term]
id: MP:0008940
name: delayed balanopreputial separation
def: "the separation of the prepuce from the glans penis (balanus), a result of the cornification of the balano-preputial epithelium, occurs at a later than expected age" [PMID:889997]
comment: Balanopreputial separation is used as an index for the onset of male puberty and is androgen-sensitive in the rat {xref="PMID:889997", terms:contributor="https://orcid.org/0000-0002-6490-7723"}
synonym: "delayed balano-preputial separation" EXACT []
synonym: "delayed preputial separation" EXACT []
synonym: "late onset of balano-preputial separation" EXACT []
synonym: "late onset of balanopreputial separation" EXACT []
synonym: "late onset of preputial separation" EXACT []
is_a: MP:0001938 ! delayed sexual maturation

[Term]
id: MP:0008941
name: reticulocytopenia
def: "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk]
synonym: "aplastic crisis" RELATED []
synonym: "decreased immature erythrocyte number" EXACT []
synonym: "decreased reticulocyte number" EXACT []
synonym: "reduced immature erythrocyte number" EXACT []
synonym: "reduced reticulocyte number" EXACT []
is_a: MP:0011913 ! abnormal reticulocyte cell number
is_a: MP:0013662 ! decreased myeloid cell number

[Term]
id: MP:0008942
name: abnormal induced cell death
def: "anomaly in the response to an agent that induces cessation of function at the cellular level" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000313 ! abnormal cell death

[Term]
id: MP:0008943
name: increased sensitivity to induced cell death
def: "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to induced cell death" EXACT []
synonym: "increased susceptibility to induced cell death" EXACT []
is_a: MP:0008942 ! abnormal induced cell death

[Term]
id: MP:0008944
name: decreased sensitivity to induced cell death
def: "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased susceptibility to induced cell death" EXACT []
synonym: "increased resistance to induced cell death" EXACT []
synonym: "reduced sensitivity to induced cell death" EXACT []
is_a: MP:0008942 ! abnormal induced cell death

[Term]
id: MP:0008945
name: hyperchromic macrocytic anemia
def: "deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal and the total amount of hemoglobin per cell is increased, but the percentage of hemoglobin per cell is usually in the normochromic range" [MGI:rbabiuk]
synonym: "hyperchromic macrocytic anaemia" EXACT []
is_a: MP:0002811 ! macrocytic anemia

[Term]
id: MP:0008946
name: abnormal neuron number
def: "anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0008947
name: increased neuron number
def: "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
is_a: MP:0008946 ! abnormal neuron number

[Term]
id: MP:0008948
name: decreased neuron number
def: "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
synonym: "reduced neuron number" EXACT []
is_a: MP:0008946 ! abnormal neuron number

[Term]
id: MP:0008949
name: increased Cajal-Retzius cell number
def: "greater number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0008030 ! abnormal Cajal-Retzius cell morphology
is_a: MP:0008947 ! increased neuron number

[Term]
id: MP:0008950
name: ventricular tachycardia
def: "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "V tach" EXACT []
synonym: "ventricular polycardia" RELATED []
synonym: "ventricular tachyrhythmia" EXACT []
synonym: "ventricular tachysystole" RELATED []
synonym: "wide-complex tachycardia" EXACT []
xref: Fyler:7160
is_a: MP:0002626 ! increased heart rate

[Term]
id: MP:0008951
name: long radius
def: "increased length of the short bone of the lateral forearm" [ISBN:0-683-40008-8]
synonym: "increased radius length" EXACT []
is_a: MP:0004695 ! increased length of long bones
is_a: MP:0030885 ! increased radius size

[Term]
id: MP:0008952
name: abnormal pancreatic delta cell physiology
def: "any functional anomaly of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
synonym: "abnormal D cell physiology" EXACT []
synonym: "abnormal pancreatic D cell physiology" EXACT []
synonym: "abnormal somatostatin-secreting cell physiology" EXACT []
is_a: MP:0010147 ! abnormal endocrine pancreas physiology

[Term]
id: MP:0008953
name: abnormal pancreatic somatostatin secretion
def: "anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs" [MESH:D06.472.699.327.700.875]
comment: Somatostatin is secreted by multiple cell types in the digestive and nervous systems.
is_a: MP:0008952 ! abnormal pancreatic delta cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0008954
name: abnormal cellular hemoglobin content
def: "anomaly in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs]
comment: CH is reported in picograms (pg).
synonym: "abnormal cellular haemoglobin content" EXACT []
synonym: "abnormal CH" EXACT []
synonym: "abnormal corpuscular haemoglobin content" EXACT []
synonym: "abnormal corpuscular hemoglobin content" EXACT []
is_a: MP:0005563 ! abnormal hemoglobin content

[Term]
id: MP:0008955
name: increased cellular hemoglobin content
def: "increase in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs]
comment: CH is reported in picograms (pg).
subset: Europhenome_Terms
subset: IMPC
synonym: "increased cellular haemoglobin content" EXACT []
synonym: "increased CH" EXACT []
synonym: "increased corpuscular haemoglobin content" EXACT []
synonym: "increased corpuscular hemoglobin content" EXACT []
is_a: MP:0008954 ! abnormal cellular hemoglobin content

[Term]
id: MP:0008956
name: decreased cellular hemoglobin content
def: "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs]
comment: CH is reported in picograms (pg).
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased cellular haemoglobin content" EXACT []
synonym: "decreased CH" EXACT []
synonym: "decreased corpuscular haemoglobin content" EXACT []
synonym: "decreased corpuscular hemoglobin content" EXACT []
synonym: "reduced CH" EXACT []
synonym: "reduced corpuscular haemoglobin content" EXACT []
synonym: "reduced corpuscular hemoglobin content" EXACT []
is_a: MP:0008954 ! abnormal cellular hemoglobin content

[Term]
id: MP:0008957
name: abnormal placenta junctional zone morphology
def: "any structural anomaly of the fetally derived placental region that separates the maternal uterine tissue from the placenta labyrinth" [PMID:16367805]
synonym: "abnormal placental junctional zone morphology" EXACT []
synonym: "placenta junctional zone dysplasia" NARROW []
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0008958
name: abnormal trophoblast glycogen cell morphology
def: "any structural anomaly of a glycogen-accumulating trophoblast cell that arises in the junctional zone of the placenta" [PMID:17039549]
synonym: "abnormal GC morphology" EXACT []
synonym: "abnormal glycogen cell morphology" EXACT []
is_a: MP:0004255 ! abnormal spongiotrophoblast layer morphology

[Term]
id: MP:0008959
name: abnormal spongiotrophoblast cell morphology
def: "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004255 ! abnormal spongiotrophoblast layer morphology

[Term]
id: MP:0008960
name: abnormal axon pruning
def: "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [https://orcid.org/0000-0003-1980-3228]
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0008961
name: abnormal basal metabolism
def: "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
synonym: "abnormal basal metabolic rate" RELATED []
synonym: "abnormal heat production" EXACT []
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0008962
name: abnormal carbon dioxide production
def: "deviation from the normal rate at which carbon dioxide leaves the blood and enters the alveolar gas" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal carbon dioxide emission" EXACT []
is_a: MP:0003948 ! abnormal gas homeostasis

[Term]
id: MP:0008963
name: increased carbon dioxide production
def: "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased carbon dioxide emission" EXACT []
is_a: MP:0008962 ! abnormal carbon dioxide production

[Term]
id: MP:0008964
name: decreased carbon dioxide production
def: "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased carbon dioxide emission" EXACT []
synonym: "reduced carbon dioxide emission" EXACT []
synonym: "reduced carbon dioxide production" RELATED []
is_a: MP:0008962 ! abnormal carbon dioxide production

[Term]
id: MP:0008965
name: increased basal metabolism
def: "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
synonym: "increased basal metabolic rate" EXACT []
synonym: "increased heat production" EXACT []
is_a: MP:0008961 ! abnormal basal metabolism

[Term]
id: MP:0008966
name: abnormal chiasmata formation
def: "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0008967
name: absent chiasmata formation
def: "during meiosis I there are no observable cross-over regions where nonsister chromatids of homologous chromosomes recombine with each other" [MGI:llw2]
is_a: MP:0008966 ! abnormal chiasmata formation

[Term]
id: MP:0008968
name: abnormal lacrimal apparatus morphology
def: "any structural anomaly of the network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal apparatus lacrimalis morphology" EXACT []
synonym: "abnormal lacrimal system morphology" EXACT []
synonym: "abnormal lacrymal system morphology" EXACT []
synonym: "lacrimal apparatus dysplasia" NARROW []
is_a: MP:0013754 ! abnormal ocular surface morphology

[Term]
id: MP:0008969
name: abnormal nasolacrimal duct morphology
def: "any structural anomaly of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity" [ISBN:0-683-40008-8]
synonym: "abnormal nasal duct morphology" EXACT []
synonym: "abnormal naso-lacrimal duct morphology" EXACT []
synonym: "nasolacrimal duct dysplasia" NARROW []
is_a: MP:0008968 ! abnormal lacrimal apparatus morphology

[Term]
id: MP:0008970
name: choanal atresia
def: "blockage of the back of the nasal passage by abnormal bony or soft tissue, usually due to failure of the bucconasal membrane to involute during development" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "internal nares atresia" EXACT []
xref: Fyler:4203
is_a: MP:0002236 ! abnormal internal nares morphology

[Term]
id: MP:0008971
name: abnormal ethmoturbinate morphology
def: "any structural anomaly of the conchae of the ethmoid bone which occupy the caudal part of the nasal fossae and form the lateral and superior portions of the turbinate bones in mammals" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal ethmoturbinals morphology" EXACT [ISBN:0-683-40008-8]
synonym: "ethmoturbinate dysplasia" NARROW []
is_a: MP:0000100 ! abnormal ethmoid bone morphology
is_a: MP:0002244 ! abnormal turbinate morphology

[Term]
id: MP:0008972
name: ethmoturbinate hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ethmoturbinate, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "ethmoturbinal hypoplasia" EXACT []
synonym: "hypoplastic ethmoturbinates" EXACT []
is_a: MP:0004477 ! turbinate hypoplasia
is_a: MP:0008971 ! abnormal ethmoturbinate morphology
is_a: MP:0030386 ! facial bone hypoplasia

[Term]
id: MP:0008973
name: decreased erythroid progenitor cell number
def: "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased BFU-E number" RELATED []
synonym: "decreased blast forming unit erythroid number" RELATED []
synonym: "decreased burst forming unit erythroid number" RELATED []
synonym: "decreased CFU-E number" RELATED []
synonym: "decreased colony forming unit erythroid number" RELATED []
synonym: "decreased erythroid precursors" EXACT []
synonym: "decreased erythroid stem cell number" RELATED []
synonym: "reduced BFU-E number" RELATED []
synonym: "reduced blast forming unit erythroid number" RELATED []
synonym: "reduced burst forming unit erythroid number" RELATED []
synonym: "reduced CFU-E number" RELATED []
synonym: "reduced colony forming unit erythroid number" RELATED []
synonym: "reduced erythroid precursors" EXACT []
synonym: "reduced erythroid stem cell number" RELATED []
is_a: MP:0008801 ! abnormal erythroid progenitor cell morphology

[Term]
id: MP:0008974
name: proportional dwarf
def: "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: In humans, dwarfism is defined as a condition in which the standing height of a person is below the third percentile.
synonym: "ateliotic dwarf" EXACT []
synonym: "proportional dwarfism" EXACT []
is_a: MP:0001265 ! decreased body size

[Term]
id: MP:0008975
name: delayed male fertility
def: "ability of a male organism to produce live offspring occurring at a later than expected age" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002683 ! delayed fertility

[Term]
id: MP:0008976
name: delayed female fertility
def: "ability of a female organism to produce live offspring occurring at a later than expected age" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002683 ! delayed fertility

[Term]
id: MP:0008977
name: abnormal vagina size
def: "anomaly in the size of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vaginal size" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0008978
name: abnormal vagina weight
def: "anomaly in the weight of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vaginal weight" EXACT []
is_a: MP:0008977 ! abnormal vagina size

[Term]
id: MP:0008979
name: increased vagina weight
def: "increase in the weight of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased vaginal weight" EXACT []
is_a: MP:0008978 ! abnormal vagina weight
is_a: MP:0008981 ! enlarged vagina

[Term]
id: MP:0008980
name: decreased vagina weight
def: "decrease in the weight of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased vaginal weight" EXACT []
synonym: "reduced vagina weight" EXACT []
synonym: "reduced vaginal weight" EXACT []
is_a: MP:0008978 ! abnormal vagina weight
is_a: MP:0008983 ! small vagina

[Term]
id: MP:0008981
name: enlarged vagina
def: "increase in the size of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased vagina size" EXACT []
synonym: "increased vaginal size" EXACT []
is_a: MP:0008977 ! abnormal vagina size

[Term]
id: MP:0008982
name: vagina hyperplasia
def: "increase in the number of normal cells in normal arrangement in the vagina, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic vagina" EXACT []
synonym: "vaginal hyperplasia" EXACT []
is_a: MP:0008981 ! enlarged vagina

[Term]
id: MP:0008983
name: small vagina
def: "decrease in the size of the female reproductive canal located between the uterus and the vulva" [https://orcid.org/0000-0002-6490-7723]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased vagina size" EXACT []
synonym: "decreased vaginal size" EXACT []
synonym: "reduced vagina size" EXACT []
synonym: "reduced vaginal size" EXACT []
is_a: MP:0008977 ! abnormal vagina size

[Term]
id: MP:0008984
name: vagina hypoplasia
alt_id: MP:0003532
def: "decrease in the number of normal cells in normal arrangement in the vagina, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic vagina" EXACT []
synonym: "rudimentary vagina" EXACT []
synonym: "vaginal hypoplasia" EXACT []
is_a: MP:0008983 ! small vagina

[Term]
id: MP:0008985
name: hemimelia
def: "congenital absence of part of an extremity, such as absent fibula with the tibia present" [ISBN:0-683-40008-8]
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0008986
name: abnormal liver parenchyma morphology
def: "any structural anomaly of the functional units of the liver including the lobules" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic parenchyma morphology" EXACT []
is_a: MP:0000598 ! abnormal liver morphology

[Term]
id: MP:0008987
name: abnormal liver lobule morphology
def: "any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8]
comment: Do not confuse this term with the anatomic lobes of the liver.
synonym: "abnormal classic lobule" EXACT []
synonym: "abnormal classical lobule" EXACT []
synonym: "abnormal hepatic lobule morphology" EXACT []
is_a: MP:0008986 ! abnormal liver parenchyma morphology

[Term]
id: MP:0008988
name: abnormal liver perisinusoidal space morphology
def: "any structural anomaly of the extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma" [ISBN:0-683-40008-8]
synonym: "abnormal hepatic perisinusoidal space morphology" EXACT []
synonym: "abnormal space of Disse morphology" EXACT []
is_a: MP:0008987 ! abnormal liver lobule morphology

[Term]
id: MP:0008989
name: abnormal liver sinusoid morphology
def: "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8]
synonym: "abnormal hepatic sinusoid morphology" EXACT []
is_a: MP:0008987 ! abnormal liver lobule morphology
is_a: MP:0009820 ! abnormal liver vasculature morphology

[Term]
id: MP:0008990
name: abnormal Ito cell morphology
def: "any structural anomaly of the fat-storing cells that line the hepatic sinusoids" [ISBN:0-683-40008-8]
synonym: "abnormal hepatic lipocytes" EXACT []
synonym: "abnormal hepatic stellate cell morphology" EXACT []
is_a: MP:0008988 ! abnormal liver perisinusoidal space morphology

[Term]
id: MP:0008991
name: abnormal bile canaliculus morphology
def: "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8]
synonym: "abnormal bile canaliculi morphology" EXACT []
synonym: "abnormal bile capillary morphology" EXACT []
is_a: MP:0008987 ! abnormal liver lobule morphology

[Term]
id: MP:0008992
name: abnormal portal lobule morphology
def: "any structural anomaly of the triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [ISBN:0-683-40008-8]
is_a: MP:0008986 ! abnormal liver parenchyma morphology

[Term]
id: MP:0008993
name: abnormal portal triad morphology
def: "any structural anomaly of the three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0008992 ! abnormal portal lobule morphology

[Term]
id: MP:0008994
name: early vaginal opening
def: "the opening of the genital canal in a female occurs at an earlier than expected age" [https://orcid.org/0000-0002-6490-7723]
synonym: "early onset of vaginal opening" EXACT []
synonym: "precocious vaginal opening" EXACT []
is_a: MP:0003378 ! early sexual maturation
is_a: MP:0020150 ! abnormal timing of vaginal opening

[Term]
id: MP:0008995
name: early reproductive senescence
def: "loss of reproductive capacity occurring at an earlier than expected age" [https://orcid.org/0000-0002-6490-7723]
synonym: "accelerated reproductive ageing" EXACT []
synonym: "accelerated reproductive aging" EXACT []
synonym: "early onset of reproductive senescence" EXACT []
synonym: "precocious reproductive senescence" EXACT []
synonym: "premature reproductive ageing" EXACT []
synonym: "premature reproductive aging" EXACT []
is_a: MP:0002161 ! abnormal fertility/fecundity
is_a: MP:0003786 ! premature aging

[Term]
id: MP:0008996
name: abnormal blood osmolality
def: "anomaly in the concentration of ions in the blood or blood fractions compared to the normal state, sometimes reported as increased or decreased osmotic fragility" [MGI:llw2]
synonym: "abnormal plasma osmolality" NARROW []
synonym: "abnormal serum osmolality" NARROW []
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0008997
name: increased blood osmolality
def: "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene]
synonym: "increased plasma osmolality" NARROW []
synonym: "increased serum osmolality" NARROW []
is_a: MP:0008996 ! abnormal blood osmolality

[Term]
id: MP:0008998
name: decreased blood osmolality
def: "decrease in the concentration of ions in the blood compared to the normal state" [MGI:hdene]
synonym: "decreased plasma osmolality" NARROW []
synonym: "decreased serum osmolality" NARROW []
synonym: "reduced plasma osmolality" NARROW []
synonym: "reduced serum osmolality" NARROW []
is_a: MP:0008996 ! abnormal blood osmolality

[Term]
id: MP:0008999
name: absent anus
def: "absence of the lower opening of the digestive tract" [ISBN:0-683-40008-8]
synonym: "absent anal opening" EXACT []
synonym: "absent anal orifice" EXACT []
synonym: "absent opening of terminal part of digestive tract" EXACT []
is_a: MP:0005034 ! abnormal anus morphology

[Term]
id: MP:0009000
name: absent cecum
def: "absence of the large sac at the ileum and large intestine junction" [ISBN:0-683-40008-8]
synonym: "absent caecum" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009001
name: absent hallux
def: "absence of the first or primary digit of the foot" [ISBN:0-683-40008-8]
synonym: "absent big toe" EXACT []
synonym: "absent great toe" RELATED []
synonym: "absent large toe" EXACT []
is_a: MP:0000561 ! adactyly
is_a: MP:0009049 ! abnormal hallux morphology
is_a: MP:0014281 ! hindlimb oligodactyly

[Term]
id: MP:0009002
name: premature hair regrowth
def: "faster initiation of the hair growth cycle (anagen) after catagen phase" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0009003
name: abnormal vibrissa number
def: "any anomaly in the number of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors" [https://orcid.org/0000-0003-4606-0597, MESH:A13.950]
synonym: "abnormal contour hair number" EXACT []
synonym: "abnormal sinus hair number" EXACT []
synonym: "abnormal touch hair number" EXACT []
synonym: "abnormal vibrissae number" EXACT []
synonym: "abnormal whisker number" EXACT []
is_a: MP:0002098 ! abnormal vibrissa morphology

[Term]
id: MP:0009004
name: progressive hair loss
def: "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2]
is_a: MP:0002073 ! abnormal hair growth

[Term]
id: MP:0009005
name: abnormal sesamoid bone of gastrocnemius morphology
def: "any structural anomaly of the small sesamoid bones situated behind the condyles of the femur" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fabella morphology" EXACT []
synonym: "medial sesamoid bone of the knee" EXACT []
is_a: MP:0002115 ! abnormal limb bone morphology

[Term]
id: MP:0009006
name: prolonged estrous cycle
def: "increase in the length of the estrous cycle" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased estrous cycle duration" RELATED []
synonym: "prolonged estrus cycle" EXACT []
synonym: "prolonged oestrous cycle" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009007
name: short estrous cycle
def: "decrease in the length of the estrous cycle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased estrous cycle duration" EXACT []
synonym: "short estrus cycle" EXACT []
synonym: "short oestrous cycle" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009008
name: delayed estrous cycle
def: "onset of the estrous cycle of females occurring at a later than expected age" [https://orcid.org/0000-0002-6490-7723]
comment: This term should only be used to annotate a delay in the onset of the first estrous cycle in female animals.
synonym: "delayed estrus cycle" EXACT []
synonym: "delayed oestrous cycle" EXACT []
synonym: "delayed onset of estrous cycling" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle
is_a: MP:0001938 ! delayed sexual maturation

[Term]
id: MP:0009009
name: absent estrous cycle
def: "failure of female animals to enter or progress through the estrous cycle" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of estrous cycle" EXACT []
synonym: "absence of estrous cycling" EXACT []
synonym: "absent estrus cycle" EXACT []
synonym: "absent oestrous cycle" EXACT []
synonym: "acyclic females" EXACT []
synonym: "anestrus" RELATED []
synonym: "estrous acyclicity" EXACT []
synonym: "failure of estrous cyclicity" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009010
name: abnormal diestrus
def: "any anomaly or aberrant timing of the last phase of the estrous cycle, during which unfertilized eggs are eliminated, the vagina and vulva are at a minimum size, and new follicles begin to undergo a rapid growth for the next ovulation; if pregnancy does not occur, the metestrous phase is ultimately followed by the diestrous phase" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal diestrous" EXACT []
synonym: "abnormal diestrous phase" EXACT []
synonym: "abnormal dioestrous" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009011
name: prolonged diestrus
def: "increase in the length of the diestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended diestrous" EXACT []
synonym: "increased diestrous phase duration" EXACT []
synonym: "prolonged diestrous" EXACT []
synonym: "prolonged dioestrous" EXACT []
is_a: MP:0009010 ! abnormal diestrus

[Term]
id: MP:0009012
name: short diestrus
def: "decrease in the length of the diestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased diestrous phase duration" EXACT []
synonym: "short diestrous" EXACT []
synonym: "short dioestrous" EXACT []
is_a: MP:0009010 ! abnormal diestrus

[Term]
id: MP:0009013
name: abnormal proestrus
def: "any anomaly or aberrant timing of the first phase of the estrous cycle which begins when a new batch of eggs reach maturity within ovarian follicles that are ripe and large; external examination of the female usually shows a bloated vulva with an open vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal proestrous" EXACT []
synonym: "abnormal proestrous phase" EXACT []
synonym: "abnormal prooestrous" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009014
name: prolonged proestrus
def: "increase in the length of the proestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended proestrous" EXACT []
synonym: "increased proestrous phase duration" EXACT []
synonym: "prolonged proestrous" EXACT []
synonym: "prolonged prooestrous" EXACT []
is_a: MP:0009013 ! abnormal proestrus

[Term]
id: MP:0009015
name: short proestrus
def: "decrease in the length of the proestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased proestrous phase duration" EXACT []
synonym: "short proestrous" EXACT []
synonym: "short prooestrous" EXACT []
is_a: MP:0009013 ! abnormal proestrus

[Term]
id: MP:0009016
name: abnormal estrus
def: "any anomaly or aberrant timing of the phase of the estrous cycle which begins with the ovulation of fully mature oocytes and during which the vulva remains in an extended state with an open vagina, and females are maximally receptive to male advances" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal estrous" EXACT []
synonym: "abnormal estrous phase" EXACT []
synonym: "abnormal oestrous" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009017
name: prolonged estrus
def: "increase in the length of the estrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended estrous" EXACT []
synonym: "increased estrous phase duration" EXACT []
synonym: "prolonged estrous" EXACT []
synonym: "prolonged oestrous" EXACT []
is_a: MP:0009016 ! abnormal estrus

[Term]
id: MP:0009018
name: short estrus
def: "decrease in the length of the estrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased estrous phase duration" EXACT []
synonym: "short estrous" EXACT []
synonym: "short oestrous" EXACT []
is_a: MP:0009016 ! abnormal estrus

[Term]
id: MP:0009019
name: abnormal metestrus
def: "any anomaly or aberrant timing of the phase of the estrous cycle which follows estrus when mature eggs move through the oviducts and into the uterus; the vulva is no longer bloated, and the vagina is now closed" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal metestrous" EXACT []
synonym: "abnormal metestrous phase" EXACT []
synonym: "abnormal metoestrous" EXACT []
is_a: MP:0001927 ! abnormal estrous cycle

[Term]
id: MP:0009020
name: prolonged metestrus
def: "increase in the length of the metestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended metestrous" EXACT []
synonym: "increased metestrous phase duration" EXACT []
synonym: "prolonged metestrous" EXACT []
synonym: "prolonged metoestrous" EXACT []
is_a: MP:0009019 ! abnormal metestrus

[Term]
id: MP:0009021
name: absent estrus
def: "absence or failure of the estrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of estrous phase" EXACT []
synonym: "absent estrous" EXACT []
synonym: "absent oestrous" EXACT []
is_a: MP:0009016 ! abnormal estrus

[Term]
id: MP:0009022
name: abnormal brain meninges morphology
def: "any structural anomaly in any of the membranes covering the brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8]
is_a: MP:0005623 ! abnormal meninges morphology

[Term]
id: MP:0009023
name: abnormal spinal cord meninges morphology
def: "any structural anomaly in any of the membranes covering the spinal cord, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8]
is_a: MP:0005623 ! abnormal meninges morphology

[Term]
id: MP:0009024
name: abnormal brain arachnoid mater morphology
def: "any structural anomaly of the fibrous membrane forming the middle of the three coverings that surrounds the brain within the cranial cavity" [ISBN:0-683-40008-8]
synonym: "abnormal arachnoidea mater cranialis morphology" EXACT []
synonym: "abnormal cranial arachnoid mater" EXACT []
is_a: MP:0009022 ! abnormal brain meninges morphology

[Term]
id: MP:0009025
name: abnormal brain dura mater morphology
def: "any structural anomaly of the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer" [ISBN:0-683-40008-8]
synonym: "abnormal cranial dura mater morphology" EXACT []
synonym: "abnormal dura mater cranialis" EXACT []
is_a: MP:0009022 ! abnormal brain meninges morphology

[Term]
id: MP:0009026
name: abnormal brain pia mater morphology
def: "any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8]
is_a: MP:0009022 ! abnormal brain meninges morphology

[Term]
id: MP:0009027
name: abnormal subarachnoid space morphology
def: "any structural anomaly of the space between the arachnoid and pia mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid" [ISBN:0-683-40008-8]
synonym: "abnormal cavum subarachnoideum morphology" EXACT []
synonym: "abnormal leptomeningeal space morphology" EXACT []
synonym: "abnormal spatium subarachnoideum morphology" EXACT []
synonym: "abnormal subarachnoid cavity morphology" EXACT []
is_a: MP:0005623 ! abnormal meninges morphology

[Term]
id: MP:0009028
name: abnormal chiasmatic cistern morphology
def: "any structural anomaly of the region of the subarachnoid space that is located below and anterior to the optic chiasm" [ISBN:0-683-40008-8]
synonym: "abnormal cistern of chiasm morphology" EXACT []
synonym: "abnormal cisterna chiasmatica morphology" EXACT []
is_a: MP:0009032 ! abnormal subarachnoid cistern morphology

[Term]
id: MP:0009029
name: abnormal basal cistern morphology
def: "any structural anomaly of the enclosed space where the arachnoid membrane stretches between the two temporal lobes and encloses the cerebral peduncles including the structures contained in the interpeduncular fossa" [ISBN:0-683-40008-8]
synonym: "abnormal cisterna basalis morphology" EXACT []
synonym: "abnormal cisterna cruralis morphology" EXACT []
synonym: "abnormal cisterna interpeduncularis morphology" EXACT []
synonym: "abnormal interpeduncular cistern morphology" EXACT []
synonym: "abnormal Tarin space morphology" EXACT []
synonym: "abnormal Tarin's space morphology" EXACT []
is_a: MP:0009032 ! abnormal subarachnoid cistern morphology

[Term]
id: MP:0009030
name: abnormal pontine cistern morphology
def: "any structural anomaly of the space located on lateral aspects of the pons at the junction with the cerebellum" [ISBN:0-683-40008-8]
synonym: "abnormal cisterna pontis morphology" EXACT []
synonym: "abnormal cisterna pontocerebellaris morphology" EXACT []
synonym: "abnormal pontocerebellar cistern morphology" EXACT []
synonym: "abnormal prepontine cistern morphology" EXACT []
is_a: MP:0009032 ! abnormal subarachnoid cistern morphology

[Term]
id: MP:0009031
name: abnormal cerebellomedullary cistern morphology
def: "any structural anomaly of the largest of the subarachnoid spaces between the cerebellum and the medulla oblongata" [ISBN:0-683-40008-8]
is_a: MP:0009032 ! abnormal subarachnoid cistern morphology

[Term]
id: MP:0009032
name: abnormal subarachnoid cistern morphology
def: "any structural anomaly of the widening portions of the subarachnoid space within the cranium where the arachnoid bridges over a depression on the surface of the brain" [ISBN:0-683-40008-8]
synonym: "abnormal cisternae subarachnoideae morphology" EXACT []
is_a: MP:0009027 ! abnormal subarachnoid space morphology

[Term]
id: MP:0009033
name: abnormal posterior cerebellomedullary cistern
def: "any structural anomaly of the space between the cerebellum and the dorsal surface of the medulla" [ISBN:0-683-40008-8]
synonym: "abnormal cisterna cerebellomedullaris posterior morphology" EXACT []
synonym: "abnormal cisterna magna morphology" EXACT []
is_a: MP:0009031 ! abnormal cerebellomedullary cistern morphology

[Term]
id: MP:0009034
name: abnormal lateral cerebellomedullary cistern morphology
def: "any structural anomaly of the space between the cerebellum and the lateral aspect of the medulla" [ISBN:0-683-40008-8]
synonym: "abnormal cisterna cerebellomedullaris lateralis morphology" EXACT []
is_a: MP:0009031 ! abnormal cerebellomedullary cistern morphology

[Term]
id: MP:0009035
name: abnormal quadrigeminal cistern morphology
def: "any structural anomaly of the enclosed space extending forward between the corpus callosum and the thalamus that contains the internal cerebral veins" [ISBN:0-683-40008-8]
synonym: "abnormal Bichat canal morphology" EXACT []
synonym: "abnormal cistern of great cerebral vein morphology" EXACT []
synonym: "abnormal cisterna quadrigeminalis morphology" EXACT []
synonym: "abnormal cisterna venae magnae cerebri morphology" EXACT []
synonym: "abnormal superior cistern morphology" EXACT []
is_a: MP:0009032 ! abnormal subarachnoid cistern morphology

[Term]
id: MP:0009036
name: absent posterior cerebellomedullary cistern
def: "absence of the space between the cerebellum and the dorsal surface of the medulla" [ISBN:0-683-40008-8]
synonym: "absent cisterna cerebellomedullaris posterior morphology" EXACT []
synonym: "absent cisterna magna morphology" EXACT []
is_a: MP:0009033 ! abnormal posterior cerebellomedullary cistern

[Term]
id: MP:0009037
name: abnormal subarachnoid space development
def: "anomaly in the formation of the space between the arachnoid and pia mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid" [ISBN:0-683-40008-8]
synonym: "abnormal cavum subarachnoideum development" EXACT []
synonym: "abnormal leptomeningeal space development" EXACT []
synonym: "abnormal spatium subarachnoideum development" EXACT []
synonym: "abnormal subarachnoid cavity development" EXACT []
is_a: MP:0009027 ! abnormal subarachnoid space morphology

[Term]
id: MP:0009038
name: decreased inferior colliculus size
def: "decreased size of the paired inferior eminence of the mesencephalic tectum" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased corpora quadrigeminum posterius size" EXACT []
synonym: "decreased inferior nasal colliculus size" EXACT []
synonym: "decreased posterior quadrigeminal body size" EXACT []
synonym: "decreased size of inferior colliculus" EXACT []
synonym: "reduced inferior colliculus size" EXACT []
synonym: "reduced size of inferior colliculus" EXACT []
synonym: "truncated inferior colliculus" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology

[Term]
id: MP:0009039
name: absent inferior colliculus
def: "absence of the paired inferior eminence of the mesencephalic tectum" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent corpora quadrigeminum posterius" EXACT []
synonym: "absent inferior nasal colliculus" EXACT []
synonym: "absent posterior quadrigeminal body" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology

[Term]
id: MP:0009040
name: absent superior colliculus
def: "absence of the paired superior eminence of the mesencephalic tectum" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent anterior quadrigeminal body" EXACT []
synonym: "absent corpora quadrigeminum posterius anterius" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology

[Term]
id: MP:0009041
name: absent colliculi
def: "absence of the inferior and superior colliculus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000899 ! abnormal corpora quadrigemina morphology

[Term]
id: MP:0009042
name: pilar cyst
def: "presence of one or more epithelial cysts of the skin arising from the outer root sheath of the hair follicle" [MGI:llw2]
synonym: "pilar cysts" EXACT []
synonym: "trichilemmal cyst" EXACT []
synonym: "trichilemmal cysts" EXACT []
is_a: MP:0002015 ! epithelioid cyst
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology
is_a: MP:0031309 ! skin cyst

[Term]
id: MP:0009043
name: increased pancreas adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreas, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "pancreatic adenoma" RELATED []
is_a: MP:0009153 ! increased pancreas tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0009044
name: increased adrenal gland adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the adrenal gland, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "adrenal adenoma" RELATED []
is_a: MP:0002031 ! increased adrenal gland tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0009045
name: muscle tetany
def: "a condition of mineral imbalance in the body that results in severe muscle spasms occurring when the concentration of calcium ions (Ca++) in extracellular fluids such as plasma falls below normal" [MGI:llw2]
synonym: "tetanic cramps" EXACT []
is_a: MP:0000743 ! muscle spasm

[Term]
id: MP:0009046
name: muscle twitch
def: "minor, sometimes imperceptible, local muscle contractions or uncontrollable movement of a single muscle group served by a single motor nerve fiber or filament sometime, but not always, indicating a neurological disorder" [MGI:llw2]
synonym: "muscle twitches" EXACT []
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0009047
name: short metestrus
def: "decrease in the length of the metestrous phase of the estrous cycle in female animals" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased metestrous phase duration" EXACT []
synonym: "short metestrous" EXACT []
synonym: "short metoestrous" EXACT []
synonym: "shortened metestrous" EXACT []
is_a: MP:0009019 ! abnormal metestrus

[Term]
id: MP:0009048
name: enlarged tectum
def: "increased size of the rostral part of the midbrain roof" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased tectum size" EXACT []
is_a: MP:0006104 ! abnormal tectum morphology

[Term]
id: MP:0009049
name: abnormal hallux morphology
def: "any structural anomaly of the first or primary digit of the foot" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal big toe morphology" EXACT []
synonym: "abnormal digitus primus morphology" BROAD []
synonym: "abnormal great toe morphology" EXACT []
synonym: "abnormal pollex pedis morphology" RELATED []
is_a: MP:0002110 ! abnormal digit morphology

[Term]
id: MP:0009050
name: dilated proximal convoluted tubule
def: "stretched or widened aperture of the luminal space of one or more of the proximal convoluted kidney tubules" [https://orcid.org/0000-0003-4606-0597]
synonym: "dilated proximal convoluted kidney tubules" EXACT []
synonym: "dilated proximal convoluted renal tubules" EXACT []
synonym: "dilated proximal convoluted tubules" EXACT []
synonym: "dilated proximal renal tubules" EXACT []
synonym: "proximal convoluted tubule dilation" EXACT []
synonym: "proximal convoluted tubule ectasia" EXACT []
synonym: "proximal renal tubule dilation" EXACT []
is_a: MP:0002705 ! dilated renal tubule
is_a: MP:0004756 ! abnormal proximal convoluted tubule morphology

[Term]
id: MP:0009051
name: dilated distal convoluted tubule
def: "stretched or widened aperture of the luminal space of one or more of the distal convoluted kidney tubules" [https://orcid.org/0000-0003-4606-0597]
synonym: "dilated distal convoluted kidney tubules" EXACT []
synonym: "dilated distal convoluted renal tubules" EXACT []
synonym: "dilated distal convoluted tubules" EXACT []
synonym: "dilated distal renal tubules" EXACT []
synonym: "distal convoluted tubule dilation" EXACT []
synonym: "distal convoluted tubule ectasia" EXACT []
synonym: "distal convoluted tubules dilation" EXACT []
synonym: "distal renal tubule dilation" RELATED []
is_a: MP:0002705 ! dilated renal tubule
is_a: MP:0004757 ! abnormal distal convoluted tubule morphology

[Term]
id: MP:0009052
name: anal stenosis
def: "abnormal narrowing or constriction of the anal canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "proctostenosis" EXACT []
synonym: "stricture of the anus" EXACT []
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0009053
name: abnormal anal canal morphology
def: "any structural anomaly in the terminal portion of the alimentary canal, which begins at the anorectal junction, where the rectal ampulla abruptly narrows as the alimentary canal pierces the pelvic diaphragm (levator ani), and ends at the anal verge, when the anoderm that lines the lower anal canal changes to hairy perianal skin; surrounded by the internal and external anal sphincters" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal canalis analis" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0009054
name: absent anal canal
def: "absence of the terminal portion of the alimentary canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "agenesis of the anal canal" EXACT []
synonym: "aplasia of the anal canal" EXACT []
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0009055
name: abnormal internal anal sphincter morphology
def: "any structural anomaly of the smooth muscle ring, formed by an increase of the circular muscle fibers of the rectum, situated at the upper end of the anal canal, internal to the outer voluntary external anal sphincter" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal sphincter muscle of anus" EXACT []
synonym: "abnormal musculus sphincter ani internus" EXACT []
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0009056
name: abnormal interleukin-21 secretion
def: "anomaly in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal IL-21 secretion" EXACT []
synonym: "abnormal IL21 secretion" EXACT []
is_a: MP:0008568 ! abnormal interleukin secretion

[Term]
id: MP:0009057
name: increased interleukin-21 secretion
def: "increase in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "increased IL-21 secretion" EXACT []
synonym: "increased IL21 secretion" EXACT []
is_a: MP:0009056 ! abnormal interleukin-21 secretion

[Term]
id: MP:0009058
name: decreased interleukin-21 secretion
def: "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "decreased IL-21 secretion" EXACT []
synonym: "decreased IL21 secretion" EXACT []
synonym: "reduced IL-21 secretion" EXACT []
synonym: "reduced IL21 secretion" EXACT []
synonym: "reduced interleukin-21 secretion" EXACT []
is_a: MP:0009056 ! abnormal interleukin-21 secretion

[Term]
id: MP:0009059
name: abnormal circulating interleukin-21 level
def: "anomaly in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "abnormal circulating IL-21 level" EXACT []
synonym: "abnormal circulating IL21 level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level

[Term]
id: MP:0009060
name: increased circulating interleukin-21 level
def: "increase in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "increased circulating IL-21 level" EXACT []
synonym: "increased circulating IL21 level" EXACT []
is_a: MP:0009059 ! abnormal circulating interleukin-21 level
is_a: MP:0014497 ! increased circulating interleukin level

[Term]
id: MP:0009061
name: decreased circulating interleukin-21 level
def: "reduction in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [https://orcid.org/0000-0003-1980-3228]
synonym: "decreased circulating IL-21 level" EXACT []
synonym: "decreased circulating IL21 level" EXACT []
synonym: "reduced circulating IL-21 level" EXACT []
synonym: "reduced circulating IL21 level" EXACT []
is_a: MP:0009059 ! abnormal circulating interleukin-21 level
is_a: MP:0014498 ! decreased circulating interleukin level

[Term]
id: MP:0009062
name: impaired lectin complement pathway
def: "abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces" [https://orcid.org/0000-0003-1980-3228]
synonym: "impaired lectin mediated complement pathway" EXACT []
synonym: "impaired lectin pathway of complement" EXACT []
is_a: MP:0002471 ! abnormal complement pathway

[Term]
id: MP:0009063
name: abnormal oviduct size
def: "anomaly in the average size of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fallopian tube size" EXACT []
synonym: "abnormal salpinges size" EXACT []
synonym: "abnormal salpinx size" EXACT []
synonym: "abnormal salpinx uterina size" EXACT []
synonym: "abnormal tuba fallopiana size" EXACT []
synonym: "abnormal tuba fallopii size" EXACT []
synonym: "abnormal tuba uterina size" EXACT []
synonym: "abnormal uterine tube size" EXACT []
is_a: MP:0003574 ! abnormal oviduct morphology

[Term]
id: MP:0009064
name: oviduct atrophy
def: "acquired diminution of the size of the oviduct associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic fallopian tubes" EXACT []
synonym: "atrophic oviduct" EXACT []
synonym: "fallopian tube atrophy" EXACT []
synonym: "salpinges atrophy" EXACT []
synonym: "salpinx atrophy" EXACT []
synonym: "salpinx uterina atrophy" EXACT []
synonym: "tuba fallopiana atrophy" EXACT []
synonym: "tuba fallopii atrophy" EXACT []
synonym: "tuba uterina atrophy" EXACT []
synonym: "uterine tube atrophy" EXACT []
is_a: MP:0009070 ! small oviduct

[Term]
id: MP:0009065
name: abnormal oviduct weight
def: "anomaly in the average weight of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fallopian tube weight" EXACT []
synonym: "abnormal salpinges weight" EXACT []
synonym: "abnormal salpinx uterina weight" EXACT []
synonym: "abnormal salpinx weight" EXACT []
synonym: "abnormal tuba fallopiana weight" EXACT []
synonym: "abnormal tuba fallopii weight" EXACT []
synonym: "abnormal tuba uterina weight" EXACT []
synonym: "abnormal uterine tube weight" EXACT []
is_a: MP:0009063 ! abnormal oviduct size

[Term]
id: MP:0009066
name: decreased oviduct weight
def: "reduction in the average weight of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased fallopian tube weight" EXACT []
synonym: "decreased salpinges weight" EXACT []
synonym: "decreased salpinx uterina weight" EXACT []
synonym: "decreased salpinx weight" EXACT []
synonym: "decreased tuba fallopiana weight" EXACT []
synonym: "decreased tuba fallopii weight" EXACT []
synonym: "decreased tuba uterina weight" EXACT []
synonym: "decreased uterine tube weight" EXACT []
synonym: "reduced fallopian tube weight" EXACT []
synonym: "reduced oviduct weight" EXACT []
synonym: "reduced salpinges weight" EXACT []
synonym: "reduced salpinx uterina weight" EXACT []
synonym: "reduced salpinx weight" EXACT []
synonym: "reduced tuba fallopiana weight" EXACT []
synonym: "reduced tuba fallopii weight" EXACT []
synonym: "reduced tuba uterina weight" EXACT []
synonym: "reduced uterine tube weight" EXACT []
is_a: MP:0009065 ! abnormal oviduct weight
is_a: MP:0009070 ! small oviduct

[Term]
id: MP:0009067
name: increased oviduct weight
def: "greater average weight of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased fallopian tube weight" EXACT []
synonym: "increased salpinges weight" EXACT []
synonym: "increased salpinx uterina weight" EXACT []
synonym: "increased salpinx weight" EXACT []
synonym: "increased tuba fallopiana weight" EXACT []
synonym: "increased tuba fallopii weight" EXACT []
synonym: "increased tuba uterina weight" EXACT []
synonym: "increased uterine tube weight" EXACT []
is_a: MP:0009065 ! abnormal oviduct weight
is_a: MP:0009068 ! enlarged oviduct

[Term]
id: MP:0009068
name: enlarged oviduct
def: "increased size of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged fallopian tubes" EXACT []
synonym: "enlarged salpinges" EXACT []
synonym: "enlarged salpinx" EXACT []
synonym: "enlarged salpinx uterina" EXACT []
synonym: "enlarged tuba fallopiana" EXACT []
synonym: "enlarged tuba fallopii" EXACT []
synonym: "enlarged tuba uterina" EXACT []
synonym: "enlarged uterine tube" EXACT []
synonym: "increased oviduct size" EXACT []
is_a: MP:0009063 ! abnormal oviduct size

[Term]
id: MP:0009069
name: dilated oviduct
def: "an expansion in the volume or area of one or both tubes through which the ova pass from the ovary to the uterus, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated fallopian tubes" EXACT []
synonym: "dilated oviducts" EXACT []
synonym: "dilated salpinges" EXACT []
synonym: "dilated salpinx" EXACT []
synonym: "dilated salpinx uterina" EXACT []
synonym: "dilated tuba fallopiana" EXACT []
synonym: "dilated tuba fallopii" EXACT []
synonym: "dilated tuba uterina" EXACT []
synonym: "dilated uterine tube" EXACT []
synonym: "dilated uterine tubes" EXACT []
synonym: "fallopian tube dilation" EXACT []
synonym: "fluid-filled fallopian tube" EXACT []
synonym: "fluid-filled oviduct" EXACT []
synonym: "fluid-filled oviducts" EXACT []
synonym: "fluid-filled salpinges" EXACT []
synonym: "fluid-filled salpinx" EXACT []
synonym: "fluid-filled uterine tube" EXACT []
synonym: "fluid-filled uterine tubes" EXACT []
synonym: "hydrops tubae" EXACT []
synonym: "hydrosalpinges" EXACT []
synonym: "hydrosalpinx" EXACT []
synonym: "oviduct dilation" EXACT []
synonym: "salpinx dilation" EXACT []
synonym: "salpinx uterina dilation" EXACT []
synonym: "uterine tube dilation" EXACT []
is_a: MP:0009063 ! abnormal oviduct size

[Term]
id: MP:0009070
name: small oviduct
def: "reduced size of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased oviduct size" EXACT []
synonym: "reduced oviduct size" EXACT []
synonym: "small fallopian tubes" EXACT []
synonym: "small salpinges" EXACT []
synonym: "small salpinx" EXACT []
synonym: "small salpinx uterina" EXACT []
synonym: "small tuba fallopiana" EXACT []
synonym: "small tuba fallopii" EXACT []
synonym: "small tuba uterina" EXACT []
synonym: "small uterine tube" EXACT []
is_a: MP:0009063 ! abnormal oviduct size

[Term]
id: MP:0009071
name: short oviduct
def: "length reduction or truncation of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "short fallopian tubes" EXACT []
synonym: "short salpinges" EXACT []
synonym: "short salpinx" EXACT []
synonym: "short salpinx uterina" EXACT []
synonym: "short tuba fallopiana" EXACT []
synonym: "short tuba fallopii" EXACT []
synonym: "short tuba uterina" EXACT []
synonym: "short uterine tube" EXACT []
synonym: "truncated fallopian tubes" EXACT []
synonym: "truncated oviduct" EXACT []
synonym: "truncated salpinges" EXACT []
synonym: "truncated salpinx" EXACT []
synonym: "truncated salpinx uterina" EXACT []
synonym: "truncated tuba fallopiana" EXACT []
synonym: "truncated tuba fallopii" EXACT []
synonym: "truncated tuba uterina" EXACT []
synonym: "truncated uterine tube" EXACT []
is_a: MP:0009070 ! small oviduct

[Term]
id: MP:0009072
name: absent cranial vagina
def: "absence of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent upper vagina" EXACT []
is_a: MP:0009077 ! abnormal cranial vagina morphology

[Term]
id: MP:0009073
name: absent Wolffian ducts
def: "absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent archinephric duct" EXACT []
synonym: "absent ductus mesonephricus" EXACT []
synonym: "absent Gartner's duct" EXACT []
synonym: "absent Leydig's duct" EXACT []
synonym: "absent mesonephric duct" EXACT []
synonym: "absent nephric duct" EXACT []
synonym: "absent pronephric duct" EXACT []
synonym: "Wolffian duct agenesis" EXACT []
synonym: "Wolffian duct aplasia" EXACT []
is_a: MP:0003827 ! abnormal Wolffian duct morphology

[Term]
id: MP:0009074
name: Wolffian duct degeneration
def: "a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [https://orcid.org/0000-0002-6490-7723]
synonym: "archinephric duct degeneration" EXACT []
synonym: "ductus mesonephricus degeneration" EXACT []
synonym: "Gartner's duct degeneration" EXACT []
synonym: "Leydig's duct degeneration" EXACT []
synonym: "mesonephric duct degeneration" EXACT []
synonym: "nephric duct degeneration" EXACT []
synonym: "pronephric duct degeneration" EXACT []
is_a: MP:0003827 ! abnormal Wolffian duct morphology

[Term]
id: MP:0009075
name: rudimentary Wolffian ducts
def: "not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [https://orcid.org/0000-0002-6490-7723]
synonym: "rudimentary archinephric duct" RELATED []
synonym: "rudimentary ductus mesonephricus" EXACT []
synonym: "rudimentary Gartner's duct" EXACT []
synonym: "rudimentary Leydig's duct" EXACT []
synonym: "rudimentary mesonephric duct" EXACT []
synonym: "rudimentary nephric duct" EXACT []
synonym: "rudimentary pronephric duct" EXACT []
is_a: MP:0003827 ! abnormal Wolffian duct morphology

[Term]
id: MP:0009076
name: rudimentary Mullerian ducts
def: "not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and cranial vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "rudimentary Muller ducts" EXACT []
synonym: "rudimentary paramesonephric ducts" EXACT []
is_a: MP:0003826 ! abnormal Mullerian duct morphology

[Term]
id: MP:0009077
name: abnormal cranial vagina morphology
def: "any structural anomaly of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal upper vagina morphology" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0009078
name: adrenal gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the adrenal gland, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "hyperplastic adrenal gland" EXACT []
is_a: MP:0000642 ! enlarged adrenal glands

[Term]
id: MP:0009079
name: prolapsed intervertebral disk
def: "extrusion of the cartilaginous and gelatinous structure found between vertebrae" [MGI:mberry]
synonym: "prolapsed intervertebral disc" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004173 ! abnormal intervertebral disk morphology

[Term]
id: MP:0009080
name: uterus inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "inflammation of the uterus" EXACT []
synonym: "metritis" EXACT []
synonym: "uterine inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0009671 ! abnormal uterus physiology

[Term]
id: MP:0009081
name: thin uterus
def: "reduced thickness or depth of the female muscular organ of gestation" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin metra" EXACT []
is_a: MP:0002637 ! small uterus

[Term]
id: MP:0009082
name: uterus cyst
def: "presence of one or more fluid-filled sacs inside the lumen of the uterus; usually refers to benign growths" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic metra" EXACT []
synonym: "cystic uterus" EXACT []
synonym: "metral cyst" EXACT []
synonym: "metral cysts" EXACT []
synonym: "uterine cyst" EXACT []
synonym: "uterine cysts" EXACT []
synonym: "uterus cysts" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0009083
name: uterus hypertrophy
def: "increase in the bulk size of the female muscular organ of gestation due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic metra" EXACT []
synonym: "hypertrophic uterus" EXACT []
synonym: "metra hypertrophy" EXACT []
synonym: "metral hypertrophy" EXACT []
synonym: "uterine hypertrophy" EXACT []
is_a: MP:0004906 ! enlarged uterus

[Term]
id: MP:0009084
name: blind uterus
def: "presence of a female muscular organ of gestation that ends in a blind segment or sac and does not communicate with the cervix or vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "blind metra" EXACT []
synonym: "blind uterine body" EXACT []
synonym: "blind-ended uterus" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0009085
name: abnormal uterine horn morphology
def: "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cornu uteri" EXACT []
synonym: "abnormal metral horn morphology" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0009086
name: blind uterine horn
def: "presence of a blind-ended segment or pouch at the junction of the uterine horn and the uterine body; the blind horn is typically distended by fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "blind cornu uteri" EXACT []
synonym: "blind metral horn" EXACT []
synonym: "blind-ended uterine horn" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology

[Term]
id: MP:0009087
name: dilated uterine horn
def: "an expansion in the volume or area of one or both of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated cornu uteri" EXACT []
synonym: "dilated metral horn" EXACT []
synonym: "dilated metral horns" EXACT []
synonym: "dilated uterine horns" EXACT []
synonym: "uterine horn dilation" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology

[Term]
id: MP:0009088
name: thin uterine horn
def: "reduced thickness of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin cornu uteri" EXACT []
synonym: "thin metral horn" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology

[Term]
id: MP:0009089
name: short uterine horn
def: "length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased uterine horn length" EXACT []
synonym: "short cornu uteri" EXACT []
synonym: "short metral horn" EXACT []
synonym: "truncated uterine horn" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology

[Term]
id: MP:0009090
name: myometrium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the myometrium, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic myometrium" EXACT []
synonym: "myometrial hypoplasia" EXACT []
synonym: "uterine smooth muscle hypoplasia" EXACT []
synonym: "uterus smooth muscle hypoplasia" RELATED []
is_a: MP:0008256 ! abnormal myometrium morphology

[Term]
id: MP:0009091
name: endometrium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the endometrium, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "endometrial hypoplasia" EXACT []
synonym: "hypoplastic endometrium" EXACT []
is_a: MP:0004896 ! abnormal endometrium morphology

[Term]
id: MP:0009092
name: endometrium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the endometrium, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "endometrial hyperplasia" EXACT []
synonym: "hyperplastic endometrium" EXACT []
is_a: MP:0004896 ! abnormal endometrium morphology

[Term]
id: MP:0009093
name: oocyte degeneration
def: "a retrogressive impairment of function or destruction of the female germ cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006361 ! abnormal female germ cell morphology

[Term]
id: MP:0009094
name: abnormal endometrial gland morphology
def: "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glandulae uterinae" EXACT []
synonym: "abnormal uterine glands" EXACT []
is_a: MP:0004896 ! abnormal endometrium morphology
is_a: MP:0013324 ! abnormal female reproductive gland morphology
is_a: MP:0014032 ! abnormal mucous gland morphology

[Term]
id: MP:0009095
name: abnormal endometrial gland number
def: "abnormal number of the simple or branched tubular glands located in the mucous membrane of the uterus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009094 ! abnormal endometrial gland morphology

[Term]
id: MP:0009096
name: decreased endometrial gland number
def: "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased number of uterine glands" EXACT []
synonym: "reduced endometrial gland number" EXACT []
synonym: "reduced number of uterine glands" EXACT []
is_a: MP:0009095 ! abnormal endometrial gland number

[Term]
id: MP:0009097
name: absent endometrial glands
def: "absence of the simple or branched tubular uterine glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent glandulae uterinae" EXACT []
synonym: "absent uterine glands" EXACT []
is_a: MP:0009095 ! abnormal endometrial gland number

[Term]
id: MP:0009098
name: anovaginal fistula
def: "an abnormal anatomical passage that connects the anal canal and the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "ano-vaginal fistula" EXACT []
is_a: MP:0001139 ! abnormal vagina morphology
is_a: MP:0009053 ! abnormal anal canal morphology

[Term]
id: MP:0009099
name: abnormal uterine NK cell physiology
def: "any functional anomaly of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy" [PMID:14568979, PMID:19800965]
synonym: "abnormal decidual natural killer cell physiology" EXACT []
synonym: "abnormal decidual NK cell physiology" EXACT []
synonym: "abnormal dNK cell physiology" EXACT []
synonym: "abnormal GMG cell physiology" EXACT []
synonym: "abnormal granulated metrial gland cell physiology" EXACT []
synonym: "abnormal uNK cell physiology" EXACT []
synonym: "abnormal uterine natural killer cell physiology" EXACT []
xref: CL:0002343
is_a: MP:0009671 ! abnormal uterus physiology
is_a: MP:0010766 ! abnormal NK cell physiology

[Term]
id: MP:0009100
name: abnormal clitoris size
def: "anomaly in the size of the small cylindrical erectile body located at the most anterior portion of the vulva" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003127 ! abnormal clitoris morphology

[Term]
id: MP:0009101
name: clitoris hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the clitoris, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "clitoral hypoplasia" EXACT []
synonym: "hypoplastic clitoris" EXACT []
is_a: MP:0003530 ! small clitoris

[Term]
id: MP:0009102
name: abnormal glans penis morphology
def: "any structural anomaly of the conic expansion of the corpus spongiosum that forms the head of the penis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal balanus" EXACT []
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0009103
name: abnormal penile bone morphology
def: "any structural anomaly of the unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal baculum" EXACT []
synonym: "abnormal os penis" EXACT []
synonym: "abnormal penis bone" EXACT []
is_a: MP:0009102 ! abnormal glans penis morphology

[Term]
id: MP:0009104
name: small penile bone
def: "size reduction or truncation of the unique bone of variable size and shape located in the glans penis of most mammals except humans" [https://orcid.org/0000-0002-6490-7723]
synonym: "small baculum" EXACT []
synonym: "small os penis" EXACT []
synonym: "small penial bone" EXACT []
synonym: "truncated penis bone" EXACT []
is_a: MP:0009103 ! abnormal penile bone morphology

[Term]
id: MP:0009105
name: penis prolapse
def: "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "penial prolapse" EXACT []
synonym: "penile prolapse" EXACT []
is_a: MP:0005187 ! abnormal penis morphology

[Term]
id: MP:0009106
name: abnormal pancreas size
def: "anomaly in the average size of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0003-3691-0324, MESH:A03.734]
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0009107
name: abnormal pancreas weight
def: "anomaly in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0003-3691-0324, MESH:A03.734]
is_a: MP:0009106 ! abnormal pancreas size

[Term]
id: MP:0009108
name: increased pancreas weight
def: "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0003-3691-0324, MESH:A03.734]
is_a: MP:0003450 ! enlarged pancreas
is_a: MP:0009107 ! abnormal pancreas weight

[Term]
id: MP:0009109
name: decreased pancreas weight
def: "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0003-3691-0324, MESH:A03.734]
synonym: "reduced pancreas weight" EXACT []
is_a: MP:0004247 ! small pancreas
is_a: MP:0009107 ! abnormal pancreas weight

[Term]
id: MP:0009110
name: pancreas hyperplasia
def: "increase in the number of normal cells in normal arrangement in the pancrease, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic pancreas" EXACT []
synonym: "pancreatic hyperplasia" EXACT []
is_a: MP:0003450 ! enlarged pancreas

[Term]
id: MP:0009111
name: pancreas hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pancreas, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic pancreas" EXACT []
synonym: "pancreatic hypoplasia" EXACT []
is_a: MP:0004247 ! small pancreas

[Term]
id: MP:0009112
name: abnormal pancreatic beta cell mass
def: "anomaly in the total physical bulk or volume of a pancreatic beta cell compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005217 ! abnormal pancreatic beta cell morphology

[Term]
id: MP:0009113
name: increased pancreatic beta cell mass
def: "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009112 ! abnormal pancreatic beta cell mass

[Term]
id: MP:0009114
name: decreased pancreatic beta cell mass
def: "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced pancreatic beta cell mass" EXACT []
is_a: MP:0009112 ! abnormal pancreatic beta cell mass

[Term]
id: MP:0009115
name: abnormal fat cell morphology
alt_id: MP:0004128
def: "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
synonym: "abnormal adipocyte morphology" EXACT []
synonym: "abnormal lipocyte morphology" EXACT [MESH:A11.329.114]
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0009116
name: abnormal brown fat cell morphology
def: "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
synonym: "abnormal brown adipocyte morphology" EXACT []
synonym: "abnormal brown lipocyte morphology" EXACT []
is_a: MP:0002971 ! abnormal brown adipose tissue morphology
is_a: MP:0009115 ! abnormal fat cell morphology

[Term]
id: MP:0009117
name: abnormal white fat cell morphology
def: "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
synonym: "abnormal white adipocyte morphology" EXACT []
synonym: "abnormal white lipocyte morphology" EXACT []
is_a: MP:0002970 ! abnormal white adipose tissue morphology
is_a: MP:0009115 ! abnormal fat cell morphology

[Term]
id: MP:0009118
name: increased white fat cell size
def: "increase in the size of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased white adipocyte size" EXACT []
synonym: "increased white lipocyte size" EXACT []
synonym: "white adipocyte hypertrophy" EXACT []
synonym: "white fat cell hypertrophy" EXACT []
synonym: "white lipocyte hypertrophy" EXACT []
is_a: MP:0006094 ! increased fat cell size
is_a: MP:0009132 ! abnormal white fat cell size

[Term]
id: MP:0009119
name: increased brown fat cell size
def: "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
synonym: "brown adipocyte hypertrophy" EXACT []
synonym: "brown fat cell hypertrophy" EXACT []
synonym: "brown lipocyte hypertrophy" EXACT []
synonym: "increased brown adipocyte size" EXACT []
synonym: "increased brown lipocyte size" EXACT []
is_a: MP:0006094 ! increased fat cell size
is_a: MP:0009135 ! abnormal brown fat cell size

[Term]
id: MP:0009120
name: abnormal white fat cell lipid droplet size
def: "anomaly in the size of the single large lipid droplet or vacuole of white fat cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal white adipocyte lipid droplet size" EXACT []
synonym: "abnormal white lipocyte lipid droplet size" EXACT []
is_a: MP:0009117 ! abnormal white fat cell morphology

[Term]
id: MP:0009121
name: increased white fat cell lipid droplet size
def: "increase in the size of the single large lipid droplet or vacuole of white fat cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased white adipocyte lipid droplet size" EXACT []
synonym: "increased white lipocyte lipid droplet size" EXACT []
is_a: MP:0009120 ! abnormal white fat cell lipid droplet size

[Term]
id: MP:0009122
name: decreased white fat cell lipid droplet size
def: "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased white adipocyte lipid droplet size" EXACT []
synonym: "decreased white lipocyte lipid droplet size" EXACT []
synonym: "reduced white adipocyte lipid droplet size" EXACT []
synonym: "reduced white fat cell lipid droplet size" EXACT []
synonym: "reduced white lipocyte lipid droplet size" EXACT []
is_a: MP:0009120 ! abnormal white fat cell lipid droplet size

[Term]
id: MP:0009123
name: abnormal brown fat cell lipid droplet size
def: "anomaly in the size of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brown adipocyte lipid droplet size" EXACT []
synonym: "abnormal brown lipocyte lipid droplet size" EXACT []
is_a: MP:0009116 ! abnormal brown fat cell morphology

[Term]
id: MP:0009124
name: increased brown fat cell lipid droplet size
def: "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased brown adipocyte lipid droplet size" EXACT []
synonym: "increased brown lipocyte lipid droplet size" EXACT []
is_a: MP:0009123 ! abnormal brown fat cell lipid droplet size

[Term]
id: MP:0009125
name: decreased brown fat cell lipid droplet size
def: "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased brown adipocyte lipid droplet size" EXACT []
synonym: "decreased brown lipocyte lipid droplet size" EXACT []
synonym: "reduced brown adipocyte lipid droplet size" EXACT []
synonym: "reduced brown fat cell lipid droplet size" EXACT []
synonym: "reduced brown lipocyte lipid droplet size" EXACT []
is_a: MP:0009123 ! abnormal brown fat cell lipid droplet size

[Term]
id: MP:0009126
name: abnormal brown fat cell number
def: "anomaly in the number of fat cells from the thermogenic form of adipose tissue" [https://orcid.org/0000-0003-3691-0324, MESH:A.10.165.114.322]
synonym: "abnormal brown adipocyte cell number" EXACT []
synonym: "abnormal brown lipocyte cell number" EXACT []
is_a: MP:0009116 ! abnormal brown fat cell morphology

[Term]
id: MP:0009127
name: increased brown fat cell number
def: "increase in the number of fat cells from the thermogenic form of adipose tissue" [https://orcid.org/0000-0003-3691-0324, MESH:A.10.165.114.322]
synonym: "increased brown adipocyte cell number" EXACT []
synonym: "increased brown lipocyte cell number" EXACT []
is_a: MP:0009126 ! abnormal brown fat cell number

[Term]
id: MP:0009128
name: decreased brown fat cell number
def: "reduction in the number of fat cells from the thermogenic form of adipose tissue" [https://orcid.org/0000-0003-3691-0324, MESH:A.10.165.114.322]
synonym: "decreased brown adipocyte cell number" EXACT []
synonym: "decreased brown lipocyte cell number" EXACT []
synonym: "reduced brown adipocyte cell number" EXACT []
synonym: "reduced brown fat cell number" EXACT []
synonym: "reduced brown lipocyte cell number" EXACT []
is_a: MP:0009126 ! abnormal brown fat cell number

[Term]
id: MP:0009129
name: abnormal white fat cell number
def: "anomaly in the number of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal white adipocyte cell number" EXACT []
synonym: "abnormal white lipocyte cell number" EXACT []
is_a: MP:0009117 ! abnormal white fat cell morphology

[Term]
id: MP:0009130
name: increased white fat cell number
def: "increase in the number of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased white adipocyte cell number" EXACT []
synonym: "increased white lipocyte cell number" EXACT []
is_a: MP:0009129 ! abnormal white fat cell number

[Term]
id: MP:0009131
name: decreased white fat cell number
def: "reduction in the number of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased white adipocyte cell number" EXACT []
synonym: "decreased white lipocyte cell number" EXACT []
synonym: "reduced white adipocyte cell number" EXACT []
synonym: "reduced white fat cell number" EXACT []
synonym: "reduced white lipocyte cell number" EXACT []
is_a: MP:0009129 ! abnormal white fat cell number

[Term]
id: MP:0009132
name: abnormal white fat cell size
def: "anomaly in the size of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal white adipocyte size" EXACT []
synonym: "abnormal white lipocyte size" EXACT []
is_a: MP:0009117 ! abnormal white fat cell morphology

[Term]
id: MP:0009133
name: decreased white fat cell size
def: "reduction in the size of fat cells with light coloration and few mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased white adipocyte size" EXACT []
synonym: "decreased white lipocyte size" EXACT []
synonym: "reduced white adipocyte size" EXACT []
synonym: "reduced white fate cell size" EXACT []
synonym: "reduced white lipocyte size" EXACT []
synonym: "white adipocyte hypotrophy" EXACT []
synonym: "white fat cell hypotrophy" EXACT []
synonym: "white lipocyte hypotrophy" EXACT []
is_a: MP:0009132 ! abnormal white fat cell size
is_a: MP:0009269 ! decreased fat cell size

[Term]
id: MP:0009134
name: abnormal brown fat lipid droplet number
def: "anomaly in the number of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009116 ! abnormal brown fat cell morphology

[Term]
id: MP:0009135
name: abnormal brown fat cell size
def: "anomaly in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
synonym: "abnormal brown adipocyte size" EXACT []
synonym: "abnormal brown lipocyte size" EXACT []
is_a: MP:0009116 ! abnormal brown fat cell morphology

[Term]
id: MP:0009136
name: decreased brown fat cell size
def: "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
synonym: "brown adipocyte hypotrophy" EXACT []
synonym: "brown fat cell hypotrophy" EXACT []
synonym: "brown lipocyte hypotrophy" EXACT []
synonym: "decreased brown adipocyte size" EXACT []
synonym: "decreased brown lipocyte size" EXACT []
synonym: "reduced brown adipocyte size" EXACT []
synonym: "reduced brown fat cell size" EXACT []
synonym: "reduced brown lipocyte size" EXACT []
is_a: MP:0009135 ! abnormal brown fat cell size
is_a: MP:0009269 ! decreased fat cell size

[Term]
id: MP:0009137
name: decreased brown fat lipid droplet number
def: "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased brown adipocyte lipid droplet number" EXACT []
synonym: "decreased brown lipocyte lipid droplet number" EXACT []
synonym: "reduced brown adipocyte lipid droplet number" EXACT []
synonym: "reduced brown fat lipid droplet number" EXACT []
synonym: "reduced brown lipocyte lipid droplet number" EXACT []
is_a: MP:0009134 ! abnormal brown fat lipid droplet number

[Term]
id: MP:0009138
name: increased brown fat lipid droplet number
def: "increase in the number of the multiple small droplets of triglycerides found in brown adipocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased brown adipocyte lipid droplet number" EXACT []
synonym: "increased brown lipocyte lipid droplet number" EXACT []
is_a: MP:0009134 ! abnormal brown fat lipid droplet number

[Term]
id: MP:0009139
name: failure of Mullerian duct regression
def: "failure of the transient embryonic paramesonephric ducts, which normally develop into the oviduct, uterus, cervix and upper vagina in the female, to regress in the male; persistence of Mullerian ducts is typically consistent with a loss of anti-Mullerian hormone signaling and may allow development of the female reproductive tract in males" [https://orcid.org/0000-0002-6490-7723]
synonym: "non-regressed Mullerian ducts" EXACT []
synonym: "persistence of Mullerian ducts in males" EXACT []
synonym: "persistent Mullerian ducts" EXACT []
is_a: MP:0003826 ! abnormal Mullerian duct morphology

[Term]
id: MP:0009140
name: dilated efferent ductule of testis
def: "an expansion in the volume or area of the lumen of one or more of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated ductuli efferentes testis" EXACT []
synonym: "dilated efferent ducts" EXACT []
synonym: "dilated efferent ductules of testis" EXACT []
synonym: "dilated vas efferens" EXACT []
synonym: "efferent ductule of testis dilation" EXACT []
synonym: "efferent ductules of testis dilation" EXACT []
synonym: "vas efferens dilation" EXACT []
is_a: MP:0004728 ! abnormal efferent ductules of testis morphology

[Term]
id: MP:0009141
name: increased prepulse inhibition
def: "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
synonym: "increased PPI" EXACT []
is_a: MP:0003088 ! abnormal prepulse inhibition

[Term]
id: MP:0009142
name: decreased prepulse inhibition
def: "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [https://orcid.org/0000-0003-4606-0597]
subset: Europhenome_Terms
subset: IMPC
synonym: "decreased PPI" EXACT []
synonym: "reduced PPI" EXACT []
synonym: "reduced prepulse inhibition" EXACT []
is_a: MP:0003088 ! abnormal prepulse inhibition

[Term]
id: MP:0009143
name: abnormal pancreatic duct morphology
def: "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8, MESH:A03.734.667]
synonym: "abnormal duct of Wirsung morphology" EXACT []
synonym: "abnormal ductus pancreaticus morphology" EXACT []
synonym: "abnormal Hoffmann duct morphology" EXACT []
synonym: "abnormal Wirsung canal morphology" EXACT []
synonym: "abnormal Wirsung's duct morphology" EXACT []
is_a: MP:0005220 ! abnormal exocrine pancreas morphology

[Term]
id: MP:0009144
name: dilated pancreatic duct
def: "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8, MESH:A03.734.667]
synonym: "dilated duct of Wirsung" EXACT []
synonym: "dilated ductus pancreaticus" EXACT []
synonym: "dilated Hoffmann duct" EXACT []
synonym: "dilated pancreatic ducts" EXACT []
synonym: "dilated Wirsung canal" EXACT []
synonym: "dilated Wirsung's duct" EXACT []
synonym: "ductus pancreaticus dilation" EXACT []
synonym: "Hoffmann duct dilation" EXACT []
synonym: "pancreatic duct dilation" EXACT []
synonym: "Wirsung canal dilation" EXACT []
synonym: "Wirsung's duct dilation" EXACT []
is_a: MP:0009143 ! abnormal pancreatic duct morphology

[Term]
id: MP:0009145
name: abnormal pancreatic acinus morphology
def: "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8]
synonym: "abnormal pancreatic acini" EXACT []
is_a: MP:0005220 ! abnormal exocrine pancreas morphology

[Term]
id: MP:0009146
name: abnormal pancreatic acinar cell morphology
def: "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal pancreatic exocrine cell morphology" BROAD []
is_a: MP:0009145 ! abnormal pancreatic acinus morphology

[Term]
id: MP:0009147
name: abnormal pancreatic acinar cell physiology
def: "any functional anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0010148 ! abnormal exocrine pancreas physiology

[Term]
id: MP:0009148
name: pancreas necrosis
def: "morphological changes resulting from pathological death of pancreas tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic pancreas" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0009149
name: decreased pancreatic acinar cell number
def: "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased pancreatic exocrine cell number" BROAD []
synonym: "pancreatic acinar cell hypoplasia" NARROW []
synonym: "reduced pancreatic acinar cell number" EXACT []
synonym: "reduced pancreatic exocrine cell number" BROAD []
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology

[Term]
id: MP:0009150
name: pancreatic acinar cell atrophy
def: "acquired diminution of the pancreatic acinar cells associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "pancreatic exocrine cell atrophy" BROAD []
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology
is_a: MP:0013295 ! pancreas atrophy

[Term]
id: MP:0009151
name: increased pancreatic ductal adenocarcinoma incidence
def: "greater than the expected number of an adenocarcinoma that arises from the pancreatic ducts, occurring in a specific population in a given time period" [MESH:C04.557.470.200.025.232.750]
synonym: "pancreatic duct cell carcinoma" RELATED []
synonym: "pancreatic ductal adenocarcinoma" RELATED []
synonym: "PDAC" RELATED []
is_a: MP:0009153 ! increased pancreas tumor incidence
is_a: MP:0009308 ! increased adenocarcinoma incidence

[Term]
id: MP:0009152
name: increased pancreatic intraepithelial neoplasia incidence
def: "greater than the expected number of noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct, occurring in a specific population in a given time period" [PMID:11342768]
synonym: "pancreatic intraepithelial neoplasia" RELATED []
synonym: "PanIN" RELATED []
is_a: MP:0009153 ! increased pancreas tumor incidence

[Term]
id: MP:0009153
name: increased pancreas tumor incidence
def: "greater than the expected number of neoplams in the pancreas occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pancreas tumour incidence" EXACT []
synonym: "pancreas cancer" RELATED []
synonym: "pancreas neoplasms" RELATED []
synonym: "pancreatic cancer" RELATED []
synonym: "pancreatic neoplasms" RELATED []
synonym: "pancreatic tumor" RELATED []
synonym: "pancreatic tumour" RELATED []
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0009154
name: pancreatic acinar hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pancreatic acinus, typically resulting in decreased size; in this context, normal cells are meant to include different cell types such as pancreatic acinar cells and pancreatic centro-acinar cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypoplastic pancreatic acinus" EXACT []
is_a: MP:0009145 ! abnormal pancreatic acinus morphology

[Term]
id: MP:0009155
name: pancreatic acinar hyperplasia
def: "increase in the number of normal cells in normal arrangement in the pancreatic acinus, typically resulting in increased size; in this context, normal cells are meant to include different cell types such as pancreatic acinar cells and pancreatic centro-acinar cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperplastic pancreatic acinus" EXACT []
is_a: MP:0009145 ! abnormal pancreatic acinus morphology

[Term]
id: MP:0009156
name: absent pancreatic acini
def: "absence of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8]
is_a: MP:0009145 ! abnormal pancreatic acinus morphology

[Term]
id: MP:0009157
name: ectopic pancreatic acinar cells
def: "abnormal position of one or more of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8]
synonym: "ectopic pancreatic exocrine cells" RELATED []
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology

[Term]
id: MP:0009158
name: absent pancreatic acinar cells
def: "absence of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8]
synonym: "absent pancreatic exocrine cell" BROAD []
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology

[Term]
id: MP:0009159
name: increased pancreatic acinar cell number
def: "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8]
synonym: "increased pancreatic exocrine cell number" BROAD []
synonym: "pancreatic acinar cell hyperplasia" NARROW []
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology

[Term]
id: MP:0009160
name: abnormal pancreatic acinar cell zymogen granule morphology
def: "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology

[Term]
id: MP:0009161
name: pancreatic acinar cell zymogen granule accumulation
def: "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009160 ! abnormal pancreatic acinar cell zymogen granule morphology

[Term]
id: MP:0009162
name: absent pancreatic acinar cell zymogen granule
def: "absence of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009160 ! abnormal pancreatic acinar cell zymogen granule morphology

[Term]
id: MP:0009163
name: absent pancreatic duct
def: "absence of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8, MESH:A03.734.667]
synonym: "absent duct of Wirsung" EXACT []
synonym: "absent ductus pancreaticus" EXACT []
synonym: "absent Hoffmann duct" EXACT []
synonym: "absent Wirsung canal" EXACT []
synonym: "absent Wirsung's duct" EXACT []
is_a: MP:0009143 ! abnormal pancreatic duct morphology

[Term]
id: MP:0009164
name: exocrine pancreas atrophy
def: "acquired diminution of the size of the acinar gland portion of the pancreas that secretes digestive enzymes, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic exocrine pancreas" EXACT []
is_a: MP:0005220 ! abnormal exocrine pancreas morphology
is_a: MP:0013295 ! pancreas atrophy

[Term]
id: MP:0009165
name: abnormal endocrine pancreas morphology
def: "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0013560 ! abnormal endocrine gland morphology

[Term]
id: MP:0009166
name: abnormal pancreatic islet number
def: "anomaly in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "abnormal islands of Langerhans number" EXACT []
synonym: "abnormal islet cell number" EXACT []
synonym: "abnormal islet of Langerhans number" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0009167
name: increased pancreatic islet number
def: "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "increased islands of Langerhans number" EXACT []
synonym: "increased islet cell number" EXACT []
synonym: "increased islet of Langerhans number" EXACT []
is_a: MP:0009166 ! abnormal pancreatic islet number

[Term]
id: MP:0009168
name: decreased pancreatic islet number
def: "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "decreased islands of Langerhans number" EXACT []
synonym: "decreased islet cell number" EXACT []
synonym: "decreased islet of Langerhans number" EXACT []
synonym: "reduced islands of Langerhans number" EXACT []
synonym: "reduced islet cell number" EXACT []
synonym: "reduced islet of Langerhans number" EXACT []
is_a: MP:0009166 ! abnormal pancreatic islet number

[Term]
id: MP:0009169
name: pancreatic islet hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pancreatic islets, typically resulting in decreased size" [MA:0000127, MESH:A03.734.414]
synonym: "hypoplastic pancreatic islets" EXACT []
is_a: MP:0009172 ! small pancreatic islets

[Term]
id: MP:0009170
name: abnormal pancreatic islet size
def: "anomaly in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "abnormal islands of Langerhans size" EXACT []
synonym: "abnormal islet cell size" EXACT []
synonym: "abnormal islet of Langerhans size" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0009171
name: enlarged pancreatic islets
def: "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "enlarged islands of Langerhans" EXACT []
synonym: "enlarged islet cell" EXACT []
synonym: "enlarged islet of Langerhans" EXACT []
synonym: "increased islands of Langerhans size" EXACT []
synonym: "increased islet cell size" EXACT []
synonym: "increased islet of Langerhans size" EXACT []
is_a: MP:0009170 ! abnormal pancreatic islet size

[Term]
id: MP:0009172
name: small pancreatic islets
def: "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "decreased islands of Langerhans size" EXACT []
synonym: "decreased islet cell size" EXACT []
synonym: "decreased islet of Langerhans size" EXACT []
synonym: "reduced islands of Langerhans size" EXACT []
synonym: "reduced islet cell size" EXACT []
synonym: "reduced islet of Langerhans size" EXACT []
synonym: "small islands of Langerhans" EXACT []
synonym: "small islet cell" EXACT []
synonym: "small islet of Langerhans" EXACT []
is_a: MP:0009170 ! abnormal pancreatic islet size

[Term]
id: MP:0009173
name: absent pancreatic islets
def: "absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
synonym: "absent islands of Langerhans" EXACT []
synonym: "absent islet cell" EXACT []
synonym: "absent islet of Langerhans" EXACT []
is_a: MP:0009168 ! decreased pancreatic islet number

[Term]
id: MP:0009174
name: absent pancreatic beta cells
def: "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
synonym: "absent insulin-secreting cells" EXACT []
synonym: "absent pancreatic B cells" EXACT []
is_a: MP:0003339 ! decreased pancreatic beta cell number

[Term]
id: MP:0009175
name: abnormal pancreatic beta cell differentiation
def: "atypical production of or inability to produce the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas, and/or accumulation of pancreatic beta cell precursors" [CL:0000169]
synonym: "abnormal insulin-secreting cell differentiation" EXACT []
synonym: "abnormal pancreatic B cell differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0005217 ! abnormal pancreatic beta cell morphology
is_a: MP:0011932 ! abnormal endocrine pancreas development

[Term]
id: MP:0009176
name: increased pancreatic alpha cell number
def: "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
synonym: "increased glucagon-secreting cell number" EXACT []
synonym: "increased pancreas alpha cell number" EXACT []
synonym: "increased pancreatic A cell number" EXACT []
is_a: MP:0020577 ! abnormal pancreatic alpha cell number

[Term]
id: MP:0009177
name: decreased pancreatic alpha cell number
def: "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
synonym: "decreased glucagon-secreting cell number" EXACT []
synonym: "decreased pancreatic A cell number" EXACT []
synonym: "reduced glucagon-secreting cell number" EXACT []
synonym: "reduced pancreatic A cell number" EXACT []
synonym: "reduced pancreatic alpha cell number" EXACT []
is_a: MP:0020577 ! abnormal pancreatic alpha cell number

[Term]
id: MP:0009178
name: absent pancreatic alpha cells
def: "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
synonym: "absent glucagon-secreting cell" EXACT []
synonym: "absent pancreatic A cell" EXACT []
is_a: MP:0009177 ! decreased pancreatic alpha cell number

[Term]
id: MP:0009179
name: abnormal pancreatic alpha cell differentiation
def: "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
synonym: "abnormal glucagon-secreting cell differentiation" EXACT []
synonym: "abnormal pancreatic A cell differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0005216 ! abnormal pancreatic alpha cell morphology
is_a: MP:0011932 ! abnormal endocrine pancreas development

[Term]
id: MP:0009180
name: increased pancreatic delta cell number
def: "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
synonym: "increased D cell number" EXACT []
synonym: "increased pancreatic D cell number" EXACT []
synonym: "increased somatostatin-secreting cell number" EXACT []
is_a: MP:0020579 ! abnormal pancreatic delta cell number

[Term]
id: MP:0009181
name: decreased pancreatic delta cell number
def: "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
synonym: "decreased D cell number" EXACT []
synonym: "decreased pancreatic D cell number" EXACT []
synonym: "decreased somatostatin-secreting cell number" EXACT []
synonym: "reduced D cell number" EXACT []
synonym: "reduced pancreatic D cell number" EXACT []
synonym: "reduced somatostatin-secreting cell number" EXACT []
is_a: MP:0020579 ! abnormal pancreatic delta cell number

[Term]
id: MP:0009182
name: absent pancreatic delta cells
def: "absence of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
synonym: "absent D cells" EXACT []
synonym: "absent pancreatic D cells" BROAD []
synonym: "absent somatostatin-secreting cells" EXACT []
is_a: MP:0009181 ! decreased pancreatic delta cell number

[Term]
id: MP:0009183
name: abnormal pancreatic delta cell differentiation
def: "atypical production of or inability to produce the cells found in the pancreas that secrete somatostatin, and/or accumulation of pancreatic delta cell precursors" [MESH:A03.556.875.875.440.854]
synonym: "abnormal D cell differentiation" EXACT []
synonym: "abnormal pancreatic D cell differentiation" EXACT []
synonym: "abnormal somatostatin-secreting cell differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0005218 ! abnormal pancreatic delta cell morphology
is_a: MP:0011932 ! abnormal endocrine pancreas development

[Term]
id: MP:0009184
name: abnormal PP cell morphology
def: "any structural anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
synonym: "abnormal F cell morphology" EXACT []
synonym: "abnormal pancreatic polypeptide cell morphology" EXACT []
synonym: "abnormal pancreatic polypeptide-secreting cell morphology" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0009185
name: increased PP cell number
def: "increased number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
synonym: "increased F cell number" EXACT []
synonym: "increased pancreatic polypeptide cell number" EXACT []
synonym: "increased pancreatic polypeptide-secreting cell number" EXACT []
is_a: MP:0009184 ! abnormal PP cell morphology

[Term]
id: MP:0009186
name: decreased PP cell number
def: "reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
synonym: "decreased F cell number" EXACT []
synonym: "decreased pancreatic polypeptide cell number" EXACT []
synonym: "decreased pancreatic polypeptide-secreting cell number" EXACT []
synonym: "reduced F cell number" EXACT []
synonym: "reduced pancreatic polypeptide cell number" EXACT []
synonym: "reduced pancreatic polypeptide-secreting cell number" EXACT []
is_a: MP:0009184 ! abnormal PP cell morphology

[Term]
id: MP:0009187
name: absent PP cells
def: "absence of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
synonym: "absent F cells" EXACT []
synonym: "absent pancreatic polypeptide cells" EXACT []
synonym: "absent pancreatic polypeptide-secreting cells" EXACT []
is_a: MP:0009186 ! decreased PP cell number

[Term]
id: MP:0009188
name: abnormal PP cell differentiation
def: "atypical production of or inability to produce the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas, and/or accumulation of PP cell precursors" [CL:0000696, MESH:A03.734.414.587]
synonym: "abnormal F cell differentiation" EXACT []
synonym: "abnormal pancreatic polypeptide cell differentiation" EXACT []
synonym: "abnormal pancreatic polypeptide-secreting cell differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0009184 ! abnormal PP cell morphology
is_a: MP:0011932 ! abnormal endocrine pancreas development

[Term]
id: MP:0009189
name: abnormal pancreatic epsilon cell morphology
def: "any structural anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
synonym: "abnormal ghrelin-secreting cell morphology" BROAD []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0009190
name: increased pancreatic epsilon cell number
def: "increase in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
synonym: "increased ghrelin-secreting cell number" BROAD []
is_a: MP:0020580 ! abnormal pancreatic epsilon cell number

[Term]
id: MP:0009191
name: decreased pancreatic epsilon cell number
def: "reduction in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
synonym: "decreased ghrelin-secreting cell number" BROAD []
synonym: "reduced ghrelin-secreting cell number" BROAD []
is_a: MP:0020580 ! abnormal pancreatic epsilon cell number

[Term]
id: MP:0009192
name: absent pancreatic epsilon cells
def: "absence of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
synonym: "absent ghrelin-secreting cell" BROAD []
is_a: MP:0009191 ! decreased pancreatic epsilon cell number

[Term]
id: MP:0009193
name: abnormal pancreatic epsilon cell differentiation
def: "atypical production of or inability to produce the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin, and/or accumulation of pancreatic epsilon cell precursors" [PMID:14970313]
synonym: "abnormal ghrelin-secreting cell differentiation" BROAD []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0009189 ! abnormal pancreatic epsilon cell morphology
is_a: MP:0011932 ! abnormal endocrine pancreas development

[Term]
id: MP:0009194
name: abnormal pancreatic epsilon cell physiology
def: "any functional anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
synonym: "abnormal ghrelin-secreting cell physiology" BROAD []
is_a: MP:0010147 ! abnormal endocrine pancreas physiology

[Term]
id: MP:0009195
name: abnormal PP cell physiology
def: "any functional anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
synonym: "abnormal F cell physiology" EXACT []
synonym: "abnormal pancreatic polypeptide cell physiology" EXACT []
synonym: "abnormal pancreatic polypeptide-secreting cell physiology" EXACT []
is_a: MP:0010147 ! abnormal endocrine pancreas physiology

[Term]
id: MP:0009196
name: abnormal pancreatic ghrelin secretion
def: "anomaly in the production and/or regulated release from pancreatic epsilon cells of a 28-amino acid, acylated, orexigenic peptide that acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis; it is cleaved from a large precursor protein, known as appetite-regulating hormone or motilin-related peptide, which contains both ghrelin and obestatin" [MESH:D06.472.699.301]
comment: Ghrelin-secreting cells are found mainly in the stomach and duodenum, but also in the jejunum, lungs, pancreatic islets, gonads, adrenal cortex, placenta, kidney and brain.
is_a: MP:0009194 ! abnormal pancreatic epsilon cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0009197
name: abnormal pancreatic polypeptide secretion
def: "anomaly in the production and/or regulated release of the 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8, MESH:D06.472.699.587.700]
synonym: "abnormal pancreatic polypeptide hormone secretion" EXACT []
synonym: "abnormal pancreatic prohormone secretion" EXACT []
synonym: "abnormal PP secretion" EXACT []
is_a: MP:0009195 ! abnormal PP cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0009198
name: abnormal male genitalia morphology
def: "any structural anomaly of the masculine organs of reproduction or generation, external or internal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal male genitals" EXACT []
synonym: "abnormal male organa genitalia" EXACT []
synonym: "abnormal masculine genital organs" EXACT []
is_a: MP:0001145 ! abnormal male reproductive system morphology

[Term]
id: MP:0009199
name: abnormal external male genitalia morphology
def: "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [https://orcid.org/0000-0002-6490-7723]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal external male genitals" EXACT []
synonym: "abnormal external male organa genitalia" EXACT []
synonym: "abnormal external masculine genital organs" EXACT []
synonym: "abnormal organa genitalia masculina externa" EXACT []
is_a: MP:0009198 ! abnormal male genitalia morphology

[Term]
id: MP:0009200
name: enlarged external male genitalia
def: "increased size of the external masculine genital organs, including the penis and scrotum" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged external male genitals" EXACT []
synonym: "increased external male genitalia size" EXACT []
synonym: "large external male organa genitalia" EXACT []
synonym: "large external masculine genital organs" EXACT []
synonym: "large organa genitalia masculina externa" EXACT []
is_a: MP:0009199 ! abnormal external male genitalia morphology

[Term]
id: MP:0009201
name: external male genitalia atrophy
def: "acquired diminution of the size of the external masculine genital organs, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic external male genitals" EXACT []
synonym: "external male genital atrophy" EXACT []
synonym: "external male organa genitalia atrophy" EXACT []
synonym: "external masculine genital organ atrophy" EXACT []
synonym: "organa genitalia masculina externa atrophy" EXACT []
is_a: MP:0009202 ! small external male genitalia

[Term]
id: MP:0009202
name: small external male genitalia
def: "reduced size of the external masculine genital organs" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased external male genitalia size" EXACT []
synonym: "reduced external male genitalia size" EXACT []
synonym: "small external male genitals" EXACT []
synonym: "small external male organa genitalia" EXACT []
synonym: "small external masculine genital organs" EXACT []
synonym: "small organa genitalia masculina externa" EXACT []
is_a: MP:0009199 ! abnormal external male genitalia morphology

[Term]
id: MP:0009203
name: external male genitalia hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the external male genitalia, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "external male genital hypoplasia" EXACT []
synonym: "external male organa genitalia hypoplasia" EXACT []
synonym: "external masculine genital organ hypoplasia" EXACT []
synonym: "hypoplastic external male genitalia" EXACT []
synonym: "hypoplastic male external genitalia" EXACT []
synonym: "organa genitalia masculina externa hypoplasia" EXACT []
xref: UMLS:C0341787
is_a: MP:0009202 ! small external male genitalia

[Term]
id: MP:0009204
name: absent external male genitalia
def: "absence of the external masculine genital organs, including the penis and scrotum" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "absent external male genitals" EXACT []
synonym: "absent external male organa genitalia" EXACT []
synonym: "absent external masculine genital organs" EXACT []
synonym: "absent organa genitalia masculina externa" EXACT []
is_a: MP:0009199 ! abnormal external male genitalia morphology

[Term]
id: MP:0009205
name: abnormal internal male genitalia morphology
def: "any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal male genital organs" EXACT []
synonym: "abnormal internal male genitals" EXACT []
synonym: "abnormal organa genitalia masculina interna" EXACT []
synonym: "abnormality of male internal genitalia" BROAD []
is_a: MP:0009198 ! abnormal male genitalia morphology

[Term]
id: MP:0009206
name: absent internal male genitalia
def: "absence of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent internal male genital organs" EXACT []
synonym: "absent internal male genitals" EXACT []
synonym: "absent organa genitalia masculina interna" EXACT []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0009207
name: internal male genitalia hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the internal male genitalia, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic internal male genitalia" EXACT []
synonym: "internal male genital hypoplasia" EXACT []
synonym: "internal male genital organ hypoplasia" EXACT []
synonym: "organa genitalia masculina interna hypoplasia" EXACT []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0009208
name: abnormal female genitalia morphology
def: "any structural anomaly of the feminine organs of reproduction or generation, external or internal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal female genitals" EXACT []
synonym: "abnormal female organa genitalia" EXACT []
synonym: "abnormal feminine genital organs" EXACT []
is_a: MP:0001119 ! abnormal female reproductive system morphology

[Term]
id: MP:0009209
name: abnormal internal female genitalia morphology
def: "any structural anomaly of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal female genital organs" EXACT []
synonym: "abnormal internal female genitals" EXACT []
synonym: "abnormal organa genitalia feminina interna" EXACT []
synonym: "abnormality of female internal genitalia" BROAD []
is_a: MP:0009208 ! abnormal female genitalia morphology

[Term]
id: MP:0009210
name: absent internal female genitalia
def: "absence of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent internal female genital organs" EXACT []
synonym: "absent internal female genitals" EXACT []
synonym: "absent organa genitalia feminina interna" EXACT []
is_a: MP:0009209 ! abnormal internal female genitalia morphology

[Term]
id: MP:0009211
name: absent external female genitalia
def: "absence of the external feminine genital organs, collectively known as the vulva" [https://orcid.org/0000-0002-6490-7723]
subset: IMPC
subset: Sanger_Terms
synonym: "absent cunnus" EXACT []
synonym: "absent external female genital organs" EXACT []
synonym: "absent external female genitals" EXACT []
synonym: "absent organa genitalia feminina externa" EXACT []
synonym: "absent vulva" EXACT []
synonym: "missing external female genitals" EXACT []
synonym: "vulval agenesis" EXACT []
synonym: "vulval aplasia" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology

[Term]
id: MP:0009212
name: vulva atrophy
def: "acquired diminution of the size of the external feminine genital organs, collectively known as the vulva, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "atrophic cunnus" EXACT []
synonym: "atrophic external female genital organs" EXACT []
synonym: "atrophic external female genitalia" EXACT []
synonym: "atrophic external female genitals" EXACT []
synonym: "atrophic organa genitalia feminina externa" EXACT []
synonym: "atrophic vulva" EXACT []
synonym: "cunnus atrophy" EXACT []
synonym: "vulval atrophy" EXACT []
is_a: MP:0003527 ! small vulva

[Term]
id: MP:0009213
name: absent male inguinal canal
def: "absence of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels normally pass from the pelvic cavity to the scrotum" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent male abdominal canal" EXACT []
synonym: "absent male canalis inguinalis" EXACT []
synonym: "absent male Velpeau canal" EXACT []
is_a: MP:0008016 ! abnormal male inguinal canal morphology

[Term]
id: MP:0009214
name: vas deferens hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the vas deferens, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "ductus deferens hypoplasia" EXACT []
synonym: "hypoplastic ductus deferens" EXACT []
synonym: "hypoplastic vas deferens" EXACT []
is_a: MP:0002769 ! abnormal vas deferens morphology

[Term]
id: MP:0009215
name: absent uterine horn
def: "absence of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cornu uteri" EXACT []
synonym: "absent metral horn" EXACT []
synonym: "missing uterine horn" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology

[Term]
id: MP:0009216
name: abnormal peritoneum morphology
def: "any structural anomaly of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal membrana abdominis" EXACT []
is_a: MP:0003257 ! abnormal abdominal wall morphology

[Term]
id: MP:0009217
name: abnormal peritoneal vaginal process morphology
def: "any structural anomaly of the peritoneal diverticulum in the embryonic lower anterior abdominal wall that traverses the inguinal canal; in the male it forms the tunica vaginalis testis and normally loses its connection with the peritoneal cavity; a persistent processus vaginalis in the female is known as the canal of Nuck" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Nuck diverticulum" EXACT []
synonym: "abnormal processus vaginalis peritonei" EXACT []
synonym: "abnormal vaginal process of peritoneum" EXACT []
synonym: "abnormal vaginal process of testis" EXACT []
is_a: MP:0009216 ! abnormal peritoneum morphology

[Term]
id: MP:0009218
name: absent peritoneal vaginal process
def: "absence of the peritoneal diverticulum in the embryonic lower anterior abdominal wall that traverses the inguinal canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent processus vaginalis peritonei" EXACT []
synonym: "absent vaginal process of peritoneum" EXACT []
synonym: "missing vaginal process of testis" EXACT []
is_a: MP:0009217 ! abnormal peritoneal vaginal process morphology

[Term]
id: MP:0009219
name: increased prostate intraepithelial neoplasia incidence
def: "higher than normal incidence of a non-invasive neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "PIN" RELATED []
synonym: "prostate intra-epithelial neoplasia" RELATED []
synonym: "prostate intraepithelial neoplasia" RELATED []
synonym: "prostatic intraepithelial neoplasia" RELATED []
is_a: MP:0010357 ! increased prostate gland tumor incidence

[Term]
id: MP:0009220
name: increased prostate gland adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm arising from prostate tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "prostate adenocarcinoma" RELATED []
synonym: "prostate gland adenocarcinoma" RELATED []
is_a: MP:0009308 ! increased adenocarcinoma incidence
is_a: MP:0010357 ! increased prostate gland tumor incidence

[Term]
id: MP:0009221
name: uterus adenomyosis
def: "a benign invasion of myometrium by endometrial tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "adenomyometritis" EXACT []
synonym: "adenomyosis" EXACT []
synonym: "adenomyosis uteri" EXACT []
synonym: "endometriosis interna" EXACT []
synonym: "endometriosis of myometrium" EXACT []
synonym: "endometriosis uterina" EXACT []
synonym: "uterine adenomyosis" EXACT []
synonym: "uterus corpus adenomyosis" EXACT []
synonym: "uterus endometriosis" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0009222
name: increased uterus tumor incidence
def: "greater than the expected number of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased uterus tumour incidence" EXACT []
synonym: "uterine mass" RELATED []
synonym: "uterine tumor" RELATED []
synonym: "uterine tumour" RELATED []
synonym: "uterus tumor" RELATED []
synonym: "uterus tumour" RELATED []
is_a: MP:0001120 ! abnormal uterus morphology
is_a: MP:0010287 ! increased reproductive system tumor incidence

[Term]
id: MP:0009223
name: increased uterus carcinoma incidence
def: "greater than the expected number of malignant neoplasms derived from uterine epithelial cells, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased uterine carcinoma incidence" EXACT []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0009222 ! increased uterus tumor incidence

[Term]
id: MP:0009224
name: absent endometrium
def: "absence of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [https://orcid.org/0000-0002-6490-7723, MESH:A05.360.319.679.490]
is_a: MP:0004896 ! abnormal endometrium morphology

[Term]
id: MP:0009225
name: abnormal uterine cervix size
def: "anomaly in the size of the lower opening of the uterus to the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal canalis cervicis uteri size" EXACT []
synonym: "abnormal caudal segment of uterus size" EXACT []
synonym: "abnormal cervical canal of uterus size" EXACT []
synonym: "abnormal cervical canal size" EXACT []
synonym: "abnormal cervix size" BROAD []
synonym: "abnormal cervix uteri size" EXACT []
synonym: "abnormal neck of uterus size" EXACT []
is_a: MP:0001135 ! abnormal uterine cervix morphology

[Term]
id: MP:0009226
name: small uterine cervix
def: "reduced size of the lower opening of the uterus to the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased canalis cervicis uteri size" EXACT []
synonym: "decreased caudal segment of uterus size" EXACT []
synonym: "decreased cervical canal of uterus size" EXACT []
synonym: "decreased cervical canal size" EXACT []
synonym: "decreased cervix size" BROAD []
synonym: "decreased cervix uteri size" EXACT []
synonym: "decreased neck of uterus size" EXACT []
synonym: "reduced canalis cervicis uteri size" EXACT []
synonym: "reduced caudal segment of uterus size" EXACT []
synonym: "reduced cervical canal of uterus size" EXACT []
synonym: "reduced cervical canal size" EXACT []
synonym: "reduced cervical size" BROAD []
synonym: "reduced cervix size" BROAD []
synonym: "reduced cervix uteri size" EXACT []
synonym: "reduced neck of uterus size" EXACT []
synonym: "small cervix" BROAD []
synonym: "small cervix uteri" EXACT []
synonym: "small neck of uterus" EXACT []
synonym: "small neck of womb" EXACT []
is_a: MP:0009225 ! abnormal uterine cervix size

[Term]
id: MP:0009227
name: uterine cervix hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the uterine cervix, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "canalis cervicis uteri hypoplasia" EXACT []
synonym: "caudal segment of uterus hypoplasia" EXACT []
synonym: "cervical canal hypoplasia" EXACT []
synonym: "cervical canal of uterus hypoplasia" EXACT []
synonym: "cervical hypoplasia" BROAD []
synonym: "cervix hypoplasia" BROAD []
synonym: "cervix uteri hypoplasia" EXACT []
synonym: "hypoplastic cervix" BROAD []
synonym: "hypoplastic neck of uterus" EXACT []
synonym: "hypoplastic neck of womb" EXACT []
synonym: "neck of uterus hypoplasia" EXACT []
is_a: MP:0009226 ! small uterine cervix

[Term]
id: MP:0009228
name: uterine cervix inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the cervix" [https://orcid.org/0000-0002-6490-7723]
synonym: "canalis cervicis uteri inflammation" EXACT []
synonym: "caudal segment of uterus inflammation" EXACT []
synonym: "cervical canal inflammation" EXACT []
synonym: "cervical canal of uterus inflammation" EXACT []
synonym: "cervical inflammation" BROAD []
synonym: "cervicitis" BROAD []
synonym: "cervix inflammation" BROAD []
synonym: "cervix uteri inflammation" EXACT []
synonym: "neck of uterus inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0009671 ! abnormal uterus physiology

[Term]
id: MP:0009229
name: abnormal neurohypophysis median eminence morphology
def: "any structural anomaly of the raised area at the infundibular region of the neurohypophysis where the secretions of the hypothalamic neurons (releasing and inhibiting regulatory hormones) collect before entering the capillary network of hypophyseal portal system" [MESH:A06.688.357.500]
synonym: "abnormal eminentia mediana hypothalami morphology" EXACT []
synonym: "abnormal medial eminence morphology" RELATED []
synonym: "abnormal median eminence morphology" EXACT []
synonym: "abnormal median eminence of hypothalamus morphology" EXACT []
synonym: "abnormal median eminence of posterior lobe of pituitary gland morphology" EXACT []
synonym: "abnormal median eminence of tuber cinereum morphology" EXACT []
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0009230
name: abnormal sperm head morphology
def: "any structural anomaly of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [https://orcid.org/0000-0002-6490-7723]
synonym: "sperm head defects" EXACT []
is_a: MP:0005578 ! teratozoospermia

[Term]
id: MP:0009231
name: detached acrosome
def: "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "detached acrosomal granule" EXACT []
synonym: "detached acrosomal vesicle" EXACT []
is_a: MP:0008898 ! abnormal acrosome morphology

[Term]
id: MP:0009232
name: abnormal sperm nucleus morphology
def: "any structural anomaly of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009230 ! abnormal sperm head morphology

[Term]
id: MP:0009233
name: enlarged sperm head
def: "increased size of the head segment of the sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged sperm heads" EXACT []
synonym: "increased sperm head size" EXACT []
synonym: "large sperm head" EXACT []
synonym: "large sperm heads" EXACT []
synonym: "large-headed sperm" EXACT []
synonym: "macrocephalic sperm" EXACT []
synonym: "macrocephalous sperm" EXACT [https://www.intechopen.com/chapters/57404]
synonym: "megacephalic sperm" EXACT []
synonym: "sperm macrocephaly" EXACT []
synonym: "sperm megacephaly" EXACT []
is_a: MP:0009230 ! abnormal sperm head morphology

[Term]
id: MP:0009234
name: absent sperm head
def: "absence of the head segment of the sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent sperm heads" EXACT []
synonym: "acephalic sperm" EXACT []
synonym: "decapitated spermatozoa" EXACT []
synonym: "headless sperm" EXACT []
synonym: "sperm acephaly" EXACT []
is_a: MP:0009230 ! abnormal sperm head morphology

[Term]
id: MP:0009235
name: small sperm head
def: "reduced size of the head segment of the sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased sperm head size" EXACT []
synonym: "microcephalic sperm" EXACT []
synonym: "microcephalous sperm" EXACT []
synonym: "reduced sperm head size" EXACT []
synonym: "small sperm heads" EXACT []
synonym: "small-headed sperm" EXACT []
synonym: "sperm microcephaly" EXACT []
is_a: MP:0009230 ! abnormal sperm head morphology

[Term]
id: MP:0009236
name: pinhead sperm
def: "a sperm head that is unusually oblong in shape and much smaller than normal; typically, pinhead sperm result when the centrioles from which the sperm tails develop are not correctly aligned opposite the developing acrosome so that sperm heads are lost and absorbed during epididymal transit" [https://orcid.org/0000-0002-6490-7723]
synonym: "pin-head sperm" EXACT []
is_a: MP:0009235 ! small sperm head

[Term]
id: MP:0009237
name: kinked sperm flagellum
def: "a sharp bend or zigzag in the sperm tail" [https://orcid.org/0000-0002-6490-7723]
synonym: "sharp sperm flagellar bending" EXACT []
synonym: "sharply bent sperm tail" EXACT []
synonym: "sperm flagellar angularity" EXACT []
synonym: "sperm flagellar angulation" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009238
name: coiled sperm flagellum
def: "abnormal twisting of the sperm flagellum into coils or spirals" [https://orcid.org/0000-0002-6490-7723]
synonym: "coiled sperm tail" EXACT []
synonym: "curly sperm tail" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009239
name: short sperm flagellum
def: "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased sperm flagellum length" EXACT []
synonym: "short sperm tail" EXACT []
synonym: "truncated sperm flagellum" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009240
name: elongated sperm flagellum
def: "increased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased sperm flagellum length" EXACT []
synonym: "long sperm flagellum" EXACT []
synonym: "long sperm tail" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009241
name: thick sperm flagellum
def: "increased distance across the short axis of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [https://orcid.org/0000-0002-6490-7723]
synonym: "thick sperm tail" EXACT []
is_a: MP:0031351 ! abnormal sperm flagellum thickness

[Term]
id: MP:0009242
name: thin sperm flagellum
def: "reduced distance across the short axis of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin sperm tail" EXACT []
is_a: MP:0031351 ! abnormal sperm flagellum thickness

[Term]
id: MP:0009243
name: hairpin sperm flagellum
def: "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hairpin-fold of the sperm flagellum" EXACT []
synonym: "flagellar hairpin bends" EXACT []
synonym: "hairpin bent sperm tail" EXACT []
synonym: "hairpin-configuration spermatozoa" EXACT []
synonym: "hairpin-curved sperm" EXACT []
synonym: "hairpin-like sperm flagellum" EXACT []
synonym: "hairpin-shaped sperm" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009244
name: abnormal acid-activated cation-mediated receptor currents
def: "change in the measured amplitude, current density or duration of response to stimulation of acid-activated cation-mediated receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0009245
name: caudal rachischisis
def: "congenitial fissure of the vertebral column at the caudal end of the body" [MGI:llw2]
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0009246
name: pale spleen
def: "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0009247
name: meteorism
alt_id: MP:0009513
def: "condition in which excess gas accumulates in the gastrointestinal tract or peritoneal cavity, often resulting in abdominal distention, excess flatulence and/or belching" [https://orcid.org/0000-0003-3691-0324]
synonym: "bloating" BROAD []
synonym: "gastrointestinal bloating" EXACT []
synonym: "tympania" EXACT []
synonym: "tympanism" EXACT []
synonym: "tympanites" EXACT []
is_a: MP:0001270 ! distended abdomen
is_a: MP:0001663 ! abnormal digestive system physiology

[Term]
id: MP:0009248
name: small caput epididymis
def: "decrease in the average size of the head of the epididymis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased caput epididymis size" EXACT []
synonym: "reduced caput" EXACT []
is_a: MP:0002660 ! abnormal caput epididymis morphology

[Term]
id: MP:0009249
name: enlarged caput epididymis
def: "increase in the average size of the head of the epididymis" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased caput epididymis size" EXACT []
is_a: MP:0002660 ! abnormal caput epididymis morphology

[Term]
id: MP:0009250
name: abnormal appendicular skeleton morphology
def: "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8]
synonym: "appendicular skeleton dysplasia" NARROW []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0009251
name: enlarged endometrial glands
def: "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged glandulae uterinae" EXACT []
synonym: "enlarged uterine glands" EXACT []
synonym: "increased endometrial gland size" EXACT []
is_a: MP:0009094 ! abnormal endometrial gland morphology

[Term]
id: MP:0009252
name: absent urinary bladder
def: "absence of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cystis urinaria" EXACT []
synonym: "absent urocyst" EXACT []
synonym: "absent urocystis" EXACT []
synonym: "absent vesica urinaria" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0009253
name: abnormal sympathetic neuron physiology
def: "any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004183 ! abnormal sympathetic nervous system physiology
is_a: MP:0010055 ! abnormal sensory neuron physiology

[Term]
id: MP:0009254
name: disorganized pancreatic islets
def: "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised pancreatic islets" EXACT []
is_a: MP:0005215 ! abnormal pancreatic islet morphology

[Term]
id: MP:0009255
name: degranulated pancreatic beta cells
def: "insulin-secreting cells of the pancreas do not contain vesicles containing insulin" [MGI:acv]
is_a: MP:0005217 ! abnormal pancreatic beta cell morphology

[Term]
id: MP:0009256
name: enlarged corpus epididymis
def: "increase in the average size of the body of the epididymis" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased corpus epididymis size" EXACT []
is_a: MP:0002661 ! abnormal corpus epididymis morphology

[Term]
id: MP:0009257
name: dilated seminiferous tubule
def: "the luminal space of one or more of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated seminiferous tubules" EXACT []
synonym: "seminiferous tubule dilation" EXACT []
is_a: MP:0002216 ! abnormal seminiferous tubule morphology

[Term]
id: MP:0009258
name: abnormal thymocyte apoptosis
def: "change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
is_a: MP:0003763 ! abnormal thymus physiology
is_a: MP:0006412 ! abnormal T cell apoptosis

[Term]
id: MP:0009259
name: abnormal vestibular saccule duct morphology
def: "any structural anomaly of the saccular portion of the utriculosaccular duct that normally extends from the sacculus to the endolymphatic duct" [ISBN:0-683-40008-8]
synonym: "abnormal saccular duct" EXACT []
synonym: "abnormal saccule duct morphology" EXACT []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0009260
name: abnormal utricle duct morphology
def: "any structural anomaly of the utricular portion of the utriculosaccular duct that normally extends from the utriculus to the endolymphatic duct" [ISBN:0-683-40008-8]
synonym: "abnormal utricular duct" EXACT []
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0009261
name: abnormal utricle valve morphology
def: "any structural anomaly of the utriculo-endolymphatic (UE) valve which is located in the antero-inferior wall of the utricle at the orifice of the utricular duct and serves to regulate endolymph volume in the endolymphatic sac, the utricle and the canals" [PMID:1238493]
synonym: "abnormal Bast's valve morphology" EXACT []
synonym: "abnormal ultriculo-endolymphatic (UE) valve morphology" EXACT []
synonym: "abnormal utricular valve morphology" EXACT []
is_a: MP:0006090 ! abnormal utricle morphology

[Term]
id: MP:0009262
name: absent semicircular canal ampulla
def: "absence of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8]
synonym: "absent abnormal membranous ampullae of the semicircular ducts" EXACT []
is_a: MP:0008488 ! abnormal semicircular canal ampulla morphology

[Term]
id: MP:0009263
name: abnormal eyelid fusion
def: "anomaly in the process by which the upper and lower eyelids are joined during development" [https://orcid.org/0000-0003-4606-0597]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later (P8-12).
subset: IMPC_Prenatal
synonym: "abnormal blephara fusion" EXACT []
synonym: "abnormal blepharon fusion" EXACT []
synonym: "abnormal eye lid fusion" EXACT []
synonym: "abnormal palpebra fusion" EXACT []
synonym: "abnormal palpenrae fusion" EXACT []
is_a: MP:0009651 ! abnormal eyelid development

[Term]
id: MP:0009264
name: failure of eyelid fusion
def: "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development; normally fused by E17 in the mouse" [MGI:llw2]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later (P8-12).
subset: IMPC_Prenatal
synonym: "failure of blepharon fusion" EXACT []
synonym: "failure of eye lid fusion" EXACT []
synonym: "failure of palpebral fusion" EXACT []
is_a: MP:0009263 ! abnormal eyelid fusion

[Term]
id: MP:0009265
name: delayed eyelid fusion
def: "later than average time of the joining of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye" [https://orcid.org/0000-0003-4606-0597]
comment: In mouse, eyelids normally fuse about 5 days prior to birth and reopen about 19 days later (P8-12).
synonym: "delayed blepharon fusion" EXACT []
synonym: "delayed eye lid fusion" EXACT []
synonym: "delayed palpebral fusion" EXACT []
is_a: MP:0009263 ! abnormal eyelid fusion

[Term]
id: MP:0009266
name: abnormal mesendoderm development
def: "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal endomesoderm development" EXACT []
is_a: MP:0001680 ! abnormal mesoderm development
is_a: MP:0001685 ! abnormal endoderm development

[Term]
id: MP:0009267
name: abnormal cerebellum fissure morphology
def: "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellar fissure morphology" EXACT []
is_a: MP:0004097 ! abnormal cerebellar cortex morphology

[Term]
id: MP:0009268
name: absent cerebellum fissure
def: "absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8]
synonym: "absent cerebellar fissure" EXACT []
is_a: MP:0009267 ! abnormal cerebellum fissure morphology

[Term]
id: MP:0009269
name: decreased fat cell size
def: "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
synonym: "decreased adipocyte size" EXACT []
synonym: "decreased lipocyte size" EXACT []
synonym: "reduced fat cell size" EXACT []
is_a: MP:0009115 ! abnormal fat cell morphology

[Term]
id: MP:0009270
name: abnormal guard hair length
def: "anomaly in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0000397 ! abnormal guard hair morphology

[Term]
id: MP:0009271
name: increased guard hair length
def: "increase in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2]
is_a: MP:0009270 ! abnormal guard hair length

[Term]
id: MP:0009272
name: decreased guard hair length
def: "reduction in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2]
synonym: "reduced guard hair length" EXACT []
is_a: MP:0009270 ! abnormal guard hair length

[Term]
id: MP:0009273
name: abnormal hair shaft melanin granule shape
def: "the form of pigment polymers in the hair shaft differs compared to controls" [MGI:llw2]
is_a: MP:0008731 ! abnormal hair shaft melanin granule morphology

[Term]
id: MP:0009274
name: buphthalmos
def: "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001296 ! macrophthalmia

[Term]
id: MP:0009275
name: bruising
def: "an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related" [https://orcid.org/0000-0002-6490-7723]
synonym: "bruise" EXACT []
synonym: "bruises" EXACT []
synonym: "contusion" EXACT []
is_a: MP:0008817 ! hematoma

[Term]
id: MP:0009276
name: ecchymosis
def: "an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0009277
name: increased brain tumor incidence
def: "greater than the expected number of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-0431-8641]
synonym: "brain tumor" RELATED []
synonym: "brain tumour" RELATED []
synonym: "increased brain tumour incidence" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0010281 ! increased nervous system tumor incidence

[Term]
id: MP:0009278
name: abnormal bone marrow cell physiology
def: "any functional anomaly of any of the cells found in the bone marrow" [https://orcid.org/0000-0003-1980-3228]
is_a: MP:0001545 ! abnormal hematopoietic system physiology

[Term]
id: MP:0009279
name: abnormal activated sperm motility
def: "any anomaly in the type of sperm mobility that is observed in freshly ejaculated sperm and is thought to help propel the sperm through the female reproductive tract to the oviduct; normally, the flagellum of an activated sperm generates a symmetrical, lower amplitude waveform that drives the sperm in a relatively straight line" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002674 ! abnormal sperm motility

[Term]
id: MP:0009280
name: decreased activated sperm motility
def: "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired activated sperm motility" EXACT []
synonym: "reduced activated sperm motility" EXACT []
is_a: MP:0002675 ! asthenozoospermia
is_a: MP:0009279 ! abnormal activated sperm motility

[Term]
id: MP:0009281
name: abnormal hyperactivated sperm motility
def: "any anomaly in the type of sperm motility that is observed in most sperm recovered from the site of fertilization and is thought to help sperm detach from the oviductal epithelium, reach the site of fertilization, and penetrate the cumulus and zona pellucida of the oocyte; normally, once sperm from most species become hyperactivated, the flagellar beat becomes asymmetrical and higher amplitude, resulting in circular or figure-eight trajectories" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002674 ! abnormal sperm motility

[Term]
id: MP:0009282
name: decreased hyperactivated sperm motility
def: "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired hyperactivated sperm motility" EXACT []
synonym: "reduced hyperactivated sperm motility" EXACT []
is_a: MP:0002675 ! asthenozoospermia
is_a: MP:0009281 ! abnormal hyperactivated sperm motility

[Term]
id: MP:0009283
name: decreased gonadal fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased epigonadal fat pad weight" NARROW [PMID:33148396, PMID:34390703]
synonym: "decreased perigonadal fat pad weight" EXACT []
synonym: "reduced gonadal fat depot" EXACT []
is_a: MP:0005335 ! abnormal gonadal fat pad morphology

[Term]
id: MP:0009284
name: abnormal sympathetic neuron innervation pattern
def: "any changes in the placement, morphology or number of nerve fibers to sympathetic termini" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001025 ! abnormal sympathetic neuron morphology
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0009285
name: increased gonadal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased epigonadal fat pad weight" NARROW [PMID:33148396, PMID:34390703]
synonym: "increased gonadal fat depot weight" EXACT []
synonym: "increased perigonadal fat pad weight" EXACT []
is_a: MP:0005335 ! abnormal gonadal fat pad morphology

[Term]
id: MP:0009286
name: increased abdominal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue in the abdomen" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased abdominal fat depot weight" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0009287
name: decreased abdominal fat pad weight
def: "less than average weight of the encapsulated adipose tissue in the abdomen" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased abdominal fat depot weight" EXACT []
synonym: "reduced abdominal fat depot weight" EXACT []
synonym: "reduced abdominal fat pad weight" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology

[Term]
id: MP:0009288
name: increased epididymal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the epididymis" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased epididymal fat depot weight" EXACT []
synonym: "increased periepididymal fat pad weight" EXACT []
is_a: MP:0020998 ! abnormal epididymal fat pad weight

[Term]
id: MP:0009289
name: decreased epididymal fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the epididymis" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased epididymal fat depot weight" EXACT []
synonym: "decreased periepididymal fat pad weight" EXACT []
synonym: "reduced epididymal fat depot weight" EXACT []
synonym: "reduced epididymal fat pad weight" EXACT []
synonym: "reduced periepididymal fat pad weight" RELATED []
is_a: MP:0020998 ! abnormal epididymal fat pad weight

[Term]
id: MP:0009290
name: increased femoral fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased femoral fat depot weight" EXACT []
is_a: MP:0008905 ! abnormal femoral fat pad morphology

[Term]
id: MP:0009291
name: decreased femoral fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased femoral fat depot weight" EXACT []
synonym: "reduced femoral fat depot weight" EXACT []
synonym: "reduced femoral fat pad weight" EXACT []
is_a: MP:0008905 ! abnormal femoral fat pad morphology

[Term]
id: MP:0009292
name: increased inguinal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue found in the groin" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased inguinal fat depot weight" EXACT []
is_a: MP:0005336 ! abnormal inguinal fat pad morphology

[Term]
id: MP:0009293
name: decreased inguinal fat pad weight
def: "less than average weight of the encapsulated adipose tissue found in the groin" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased inguinal fat depot weight" EXACT []
synonym: "reduced inguinal fat depot weight" EXACT []
synonym: "reduced inguinal fat pad weight" EXACT []
is_a: MP:0005336 ! abnormal inguinal fat pad morphology

[Term]
id: MP:0009294
name: increased interscapular fat pad weight
def: "greater than average weight of the encapsulated adipose tissue located between the scapulae" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased interscapular fat depot weight" EXACT []
is_a: MP:0006320 ! abnormal interscapular fat pad morphology

[Term]
id: MP:0009295
name: decreased interscapular fat pad weight
def: "less than average weight of the encapsulated adipose tissue located between the scapulae" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased interscapular fat depot weight" EXACT []
synonym: "reduced interscapular fat depot weight" EXACT []
synonym: "reduced interscapular fat pad weight" EXACT []
is_a: MP:0006320 ! abnormal interscapular fat pad morphology

[Term]
id: MP:0009296
name: increased mammary fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the mammary gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mammary fat depot weight" EXACT []
is_a: MP:0008904 ! abnormal mammary fat pad morphology

[Term]
id: MP:0009297
name: decreased mammary fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the mammary gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mammary fat depot weight" EXACT []
synonym: "reduced mammary fat depot weight" EXACT []
synonym: "reduced mammary fat pad weight" EXACT []
is_a: MP:0008904 ! abnormal mammary fat pad morphology

[Term]
id: MP:0009298
name: increased mesenteric fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the mesentery" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mesenteric fat depot weight" EXACT []
is_a: MP:0008903 ! abnormal mesenteric fat pad morphology

[Term]
id: MP:0009299
name: decreased mesenteric fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the mesentery" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mesenteric fat depot weight" EXACT []
synonym: "reduced mesenteric fat depot weight" EXACT []
synonym: "reduced mesenteric fat pad weight" EXACT []
is_a: MP:0008903 ! abnormal mesenteric fat pad morphology

[Term]
id: MP:0009300
name: increased parametrial fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased parametrial fat depot weight" EXACT []
is_a: MP:0008906 ! abnormal parametrial fat pad morphology

[Term]
id: MP:0009301
name: decreased parametrial fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased parametrial fat depot weight" EXACT []
synonym: "reduced parametrial fat depot weight" EXACT []
synonym: "reduced parametrial fat pad weight" EXACT []
is_a: MP:0008906 ! abnormal parametrial fat pad morphology

[Term]
id: MP:0009302
name: increased renal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the kidney" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased renal fat depot weight" EXACT []
is_a: MP:0008902 ! abnormal renal fat pad morphology

[Term]
id: MP:0009303
name: decreased renal fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the kidney" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased renal fat depot weight" EXACT []
synonym: "reduced renal fat depot weight" EXACT []
synonym: "reduced renal fat pad weight" EXACT []
is_a: MP:0008902 ! abnormal renal fat pad morphology

[Term]
id: MP:0009304
name: increased retroperitoneal fat pad weight
def: "greater than average weight of the encapsulated adipose tissue found on the dorsal side of the peritoneum" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased retroperitoneal fat depot weight" EXACT []
is_a: MP:0005337 ! abnormal retroperitoneal fat pad morphology

[Term]
id: MP:0009305
name: decreased retroperitoneal fat pad weight
def: "less than average weight of the encapsulated adipose tissue found on the dorsal side of the peritoneum" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased retroperitoneal fat depot weight" EXACT []
synonym: "reduced retroperitoneal fat depot weight" EXACT []
synonym: "reduced retroperitoneal fat pad weight" EXACT []
is_a: MP:0005337 ! abnormal retroperitoneal fat pad morphology

[Term]
id: MP:0009306
name: increased uterine fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the uterus" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased uterine fat depot weight" EXACT []
is_a: MP:0008900 ! abnormal uterine fat pad morphology

[Term]
id: MP:0009307
name: decreased uterine fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the uterus" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased uterine fat depot weight" EXACT []
synonym: "reduced uterine fat depot weight" EXACT []
synonym: "reduced uterine fat pad weight" EXACT []
is_a: MP:0008900 ! abnormal uterine fat pad morphology

[Term]
id: MP:0009308
name: increased adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8]
synonym: "adenocarcinoma" RELATED []
synonym: "glandular cancer" EXACT []
synonym: "glandular carcinoma" EXACT []
is_a: MP:0002038 ! increased carcinoma incidence

[Term]
id: MP:0009309
name: increased small intestine adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "small intestinal adenocarcinoma" RELATED []
synonym: "small intestine adenocarcinoma" RELATED []
is_a: MP:0002957 ! increased intestinal adenocarcinoma incidence

[Term]
id: MP:0009310
name: increased large intestine adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the large intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "large intestinal adenocarcinoma" RELATED []
synonym: "large intestine adenocarcinoma" RELATED []
is_a: MP:0002957 ! increased intestinal adenocarcinoma incidence

[Term]
id: MP:0009311
name: increased duodenum adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the duodenum" [https://orcid.org/0000-0002-6490-7723]
synonym: "duodenal adenocarcinoma" RELATED []
synonym: "duodenum adenocarcinoma" RELATED []
is_a: MP:0009309 ! increased small intestine adenocarcinoma incidence

[Term]
id: MP:0009312
name: increased jejunum adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the jejunum" [https://orcid.org/0000-0002-6490-7723]
synonym: "jejunum adenocarcinoma" RELATED []
is_a: MP:0009309 ! increased small intestine adenocarcinoma incidence

[Term]
id: MP:0009313
name: increased cecum adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the cecum" [https://orcid.org/0000-0002-6490-7723]
synonym: "cecum adenocarcinoma" RELATED []
is_a: MP:0009310 ! increased large intestine adenocarcinoma incidence

[Term]
id: MP:0009314
name: increased colon adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "colon adenocarcinoma" RELATED []
synonym: "colonic adenocarcinoma" RELATED []
is_a: MP:0009310 ! increased large intestine adenocarcinoma incidence

[Term]
id: MP:0009315
name: increased rectum adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the rectum" [https://orcid.org/0000-0002-6490-7723]
synonym: "rectal adenocarcinoma" RELATED []
synonym: "rectum adenocarcinoma" RELATED []
is_a: MP:0009310 ! increased large intestine adenocarcinoma incidence

[Term]
id: MP:0009316
name: increased anal adenocarcinoma incidence
def: "higher than normal incidence of a malignant neoplasm of epithelial cells in the anal canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "anal adenocarcinoma" RELATED []
synonym: "anal canal adenocarcinoma" RELATED []
is_a: MP:0009310 ! increased large intestine adenocarcinoma incidence

[Term]
id: MP:0009317
name: increased follicular lymphoma incidence
def: "higher than normal incidence of malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8]
synonym: "follicular lymphoma" RELATED []
synonym: "giant follicular lymphoblastoma" RELATED []
synonym: "nodular lymphoma" RELATED []
is_a: MP:0002023 ! increased B cell derived lymphoma incidence

[Term]
id: MP:0009318
name: increased splenic marginal zone lymphoma incidence
def: "higher than normal incidence of neoplasms arising from the B cell-rich zones of the spleen" [ISBN:0-683-40008-8]
synonym: "splenic marginal zone lymphoma" RELATED []
is_a: MP:0002023 ! increased B cell derived lymphoma incidence

[Term]
id: MP:0009319
name: increased small lymphocytic lymphoma incidence
def: "higher than normal incidence of lymphocytic leukemia where the lymphocytes are not increased in the peripheral blood, but lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes" [ISBN:0-683-40008-8]
synonym: "small lymphocytic lymphoma" RELATED []
synonym: "well-differentiated lymphocytic lymphoma" RELATED []
is_a: MP:0002023 ! increased B cell derived lymphoma incidence

[Term]
id: MP:0009320
name: increased lymphoblastic lymphoma incidence
def: "higher than normal incidence of diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei" [ISBN:0-683-40008-8]
synonym: "lymphoblastic lymphoma" RELATED []
synonym: "lymphoblastoma" RELATED []
is_a: MP:0002024 ! increased T cell derived lymphoma incidence

[Term]
id: MP:0009321
name: increased histiocytic sarcoma incidence
def: "greater than the expected number of malignant tumors derived from histiocytes in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002032 ! increased sarcoma incidence
is_a: MP:0012431 ! increased lymphoma incidence

[Term]
id: MP:0009322
name: increased splenocyte apoptosis
def: "increase in the number of spleen cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased spleen cell apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0009340 ! abnormal splenocyte apoptosis

[Term]
id: MP:0009323
name: abnormal spleen development
def: "aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal spleen formation" EXACT []
synonym: "abnormal spleen organogenesis" EXACT []
synonym: "abnormal splenic development" EXACT []
synonym: "spleen dysgenesis" EXACT []
synonym: "splenic dysgenesis" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology
is_a: MP:0020981 ! abnormal immune system development

[Term]
id: MP:0009324
name: absent hippocampal fimbria
def: "absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8, MESH:A08.186.211.464.265]
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology

[Term]
id: MP:0009325
name: necrospermia
def: "condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2]
synonym: "necrozoospermia" EXACT []
is_a: MP:0001124 ! abnormal gametes
is_a: MP:0001156 ! abnormal spermatogenesis
is_a: MP:0002673 ! abnormal sperm number

[Term]
id: MP:0009326
name: absent maternal crouching
def: "females do not assume a position over young that facilitates suckling behavior" [MGI:llw2]
synonym: "absent nursing posture" EXACT []
is_a: MP:0001382 ! abnormal nursing

[Term]
id: MP:0009327
name: abnormal maternal grooming
def: "females show an anomaly in eliciting the cleaning or tactile stimulus level necessary to initiate nursing by offspring" [MGI:llw2]
is_a: MP:0001386 ! abnormal maternal nurturing

[Term]
id: MP:0009328
name: delayed heart looping
def: "late onset of the initiation and/or completion of looping of the primitive heart tube" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed cardiac looping" EXACT []
is_a: MP:0000269 ! abnormal heart looping
is_a: MP:0012082 ! delayed heart development

[Term]
id: MP:0009329
name: abnormal primitive pit morphology
def: "any structural anomaly of the small depression in the primitive streak that is caudal to the primitive node where the cells of the epiblast initially begin to invaginate during early embryogenesis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002231 ! abnormal primitive streak morphology

[Term]
id: MP:0009330
name: abnormal primitive groove morphology
def: "any structural anomaly of the shallow valley that extends along the length of the primitive streak" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002231 ! abnormal primitive streak morphology

[Term]
id: MP:0009331
name: absent primitive node
def: "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent embryonic node" EXACT []
synonym: "absent Hensen's node" RELATED []
synonym: "absent Henson's node" RELATED []
synonym: "absent primitive knot" EXACT []
synonym: "absent prochordal knot" EXACT []
synonym: "absent Spemann's organizer" RELATED []
is_a: MP:0004066 ! abnormal primitive node morphology

[Term]
id: MP:0009332
name: abnormal splenocyte morphology
def: "any structural anomaly of a cell of the spleen" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "abnormal spleen cell morphology" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology

[Term]
id: MP:0009333
name: abnormal splenocyte physiology
def: "any functional anomaly of a cell of the spleen" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "abnormal spleen cell physiology" EXACT []
is_a: MP:0001545 ! abnormal hematopoietic system physiology
is_a: MP:0008737 ! abnormal spleen physiology

[Term]
id: MP:0009334
name: abnormal splenocyte proliferation
def: "anomaly in the ability of a splenocyte cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "abnormal spleen cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0009333 ! abnormal splenocyte physiology

[Term]
id: MP:0009335
name: decreased splenocyte proliferation
def: "reduction in the expansion rate of a splenocyte cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "decreased spleen cell proliferation" EXACT []
synonym: "reduced spleen cell proliferation" EXACT []
synonym: "reduced splenocyte proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009334 ! abnormal splenocyte proliferation

[Term]
id: MP:0009336
name: increased splenocyte proliferation
def: "increase in the expansion rate of a splenocyte cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "increased spleen cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0009334 ! abnormal splenocyte proliferation

[Term]
id: MP:0009337
name: abnormal splenocyte number
def: "deviation from the expected number of cells of the spleen" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "abnormal spleen cell number" EXACT []
is_a: MP:0009332 ! abnormal splenocyte morphology

[Term]
id: MP:0009338
name: increased splenocyte number
def: "increase in the expected number of cells of the spleen" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "increased spleen cell number" EXACT []
is_a: MP:0009337 ! abnormal splenocyte number

[Term]
id: MP:0009339
name: decreased splenocyte number
def: "reduction in the expected number of cells of the spleen" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "decreased spleen cell number" EXACT []
synonym: "reduced spleen cell number" EXACT []
synonym: "reduced splenocyte number" EXACT []
is_a: MP:0009337 ! abnormal splenocyte number

[Term]
id: MP:0009340
name: abnormal splenocyte apoptosis
def: "deviation in the number of spleen cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "abnormal spleen cell apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0009333 ! abnormal splenocyte physiology

[Term]
id: MP:0009341
name: decreased splenocyte apoptosis
def: "reduction in the number of spleen cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
comment: Splenocytes can be any one of the different white blood cell types in the spleen. Splenocyte is a vague term, but this name is seen many references as such and is not explained futher, necessitating a need for this terminology.
synonym: "decreased spleen cell apoptosis" EXACT []
synonym: "reduced spleen cell apoptosis" EXACT []
synonym: "reduced splenocyte apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0009340 ! abnormal splenocyte apoptosis

[Term]
id: MP:0009342
name: enlarged gallbladder
def: "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged cholecyst" EXACT []
synonym: "enlarged gall bladder" EXACT []
synonym: "increased gallbladder size" EXACT []
is_a: MP:0013328 ! visceromegaly
is_a: MP:0020134 ! abnormal gallbladder size

[Term]
id: MP:0009343
name: dilated gallbladder
def: "abnormal distention of the gall bladder due to accumulation of fluid or bile" [https://orcid.org/0000-0002-6490-7723]
synonym: "cholecyst dilation" EXACT []
synonym: "dilated cholecyst" RELATED []
synonym: "dilated gall bladder" EXACT []
synonym: "dilated gall bladders" EXACT []
synonym: "dilated gallbladders" EXACT []
synonym: "distended gall bladder" EXACT []
synonym: "gall bladder dilation" EXACT []
synonym: "gallbladder dilation" EXACT []
is_a: MP:0005084 ! abnormal gallbladder morphology

[Term]
id: MP:0009344
name: abnormal ovulation cycle
def: "any anomaly in the type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years" [GO:0042698]
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0009345
name: abnormal trabecular bone thickness
def: "anomaly in the width of bone that has a lattice-like or spongy structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cancellous bone thickness" EXACT []
synonym: "abnormal spongy bone thickness" EXACT []
synonym: "abnormal spongy spongiosa thickness" EXACT []
synonym: "abnormal spongy substance thickness" EXACT []
synonym: "abnormal substantia trabecularis thickness" EXACT []
is_a: MP:0000130 ! abnormal trabecular bone morphology

[Term]
id: MP:0009346
name: decreased trabecular bone thickness
def: "thinner than normal bone with a lattice-like or spongy structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cancellous bone thickness" EXACT []
synonym: "decreased spongy bone thickness" EXACT []
synonym: "decreased spongy spongiosa thickness" EXACT []
synonym: "decreased spongy substance thickness" EXACT []
synonym: "decreased substantia trabecularis thickness" EXACT []
synonym: "reduced cancellous bone thickness" EXACT []
synonym: "reduced spongy bone thickness" EXACT []
synonym: "reduced spongy spongiosa thickness" EXACT []
synonym: "reduced spongy substance thickness" EXACT []
synonym: "reduced substantia trabecularis thickness" EXACT []
is_a: MP:0009345 ! abnormal trabecular bone thickness

[Term]
id: MP:0009347
name: increased trabecular bone thickness
def: "thicker than normal bone with a lattice-like or spongy structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cancellous bone thickness" EXACT []
synonym: "increased spongy bone thickness" EXACT []
synonym: "increased spongy spongiosa thickness" EXACT []
synonym: "increased spongy substance thickness" EXACT []
synonym: "increased substantia trabecularis thickness" EXACT []
is_a: MP:0009345 ! abnormal trabecular bone thickness

[Term]
id: MP:0009348
name: abnormal urine pH
def: "any anomaly in urinary pH, indicating alterations in urine acidity or alkalinity" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0009349
name: increased urine pH
def: "increased urine alkalinity" [https://orcid.org/0000-0002-6490-7723]
synonym: "alkaline urine" EXACT []
is_a: MP:0009348 ! abnormal urine pH

[Term]
id: MP:0009350
name: decreased urine pH
def: "increased urine acidity" [https://orcid.org/0000-0002-6490-7723]
synonym: "acidic urine" EXACT []
is_a: MP:0009348 ! abnormal urine pH

[Term]
id: MP:0009351
name: thin hair shaft
def: "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2]
is_a: MP:0003809 ! abnormal hair shaft morphology

[Term]
id: MP:0009352
name: impaired spacing of implantation sites
def: "in organisms which give birth to multiple offspring in one litter, blastocysts fail to implant at intervals conducive to the formation of a normal enveloping membrane or decidua for each conceptus from the epithelial tissue of the endometrium lining of the uterus" [MGI:llw2]
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009353
name: twin decidual capsule
def: "two embryos share one decidual membrane" [MGI:llw2]
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009354
name: emprosthotonos
def: "a form of tetanic spasm in which the head and feet are drawn forward and the spine arches backward" [MGI:llw2]
is_a: MP:0000743 ! muscle spasm
is_a: MP:0003492 ! abnormal involuntary movement

[Term]
id: MP:0009355
name: increased liver triglyceride level
def: "greater concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased hepatic triglyceride level" EXACT []
is_a: MP:0005317 ! increased triglyceride level
is_a: MP:0012778 ! abnormal liver triglyceride level

[Term]
id: MP:0009356
name: decreased liver triglyceride level
def: "reduced concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hepatic triglyceride level" EXACT []
synonym: "reduced hepatic triglyceride level" EXACT []
synonym: "reduced liver triglyceride level" EXACT []
is_a: MP:0005318 ! decreased triglyceride level
is_a: MP:0012778 ! abnormal liver triglyceride level

[Term]
id: MP:0009357
name: abnormal seizure response to inducing agent
def: "anomaly in the seizure activity response to an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [MGI:llw2]
synonym: "induced seizures" EXACT []
is_a: MP:0002064 ! seizures

[Term]
id: MP:0009358
name: environmentally induced seizures
def: "seizure activity response due to changes in ambient habitat including room temperature, lighting, sounds, touching, and/ or moving cage" [MGI:llw2]
is_a: MP:0009357 ! abnormal seizure response to inducing agent

[Term]
id: MP:0009359
name: endometrium atrophy
def: "acquired diminution of the size of the uterine endometrium, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "endometrial atrophy" EXACT []
is_a: MP:0004896 ! abnormal endometrium morphology

[Term]
id: MP:0009360
name: endometrium inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the endometrium" [https://orcid.org/0000-0002-6490-7723]
synonym: "endometrial inflammation" EXACT []
synonym: "endometritis" EXACT []
is_a: MP:0009080 ! uterus inflammation

[Term]
id: MP:0009361
name: abnormal primordial ovarian follicle morphology
def: "any structural anomaly in the ovarian follicle that is indiscernible to the naked eye and develops into to primary, secondary, and finally mature vesicular follicles" [UBERON:0003981]
is_a: MP:0001131 ! abnormal ovarian follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0009362
name: abnormal primary ovarian follicle morphology
def: "any structural anomaly in the ovarian follicle that is characterized by the presence of a single layer of granulosa cells" [UBERON:0000035]
synonym: "abnormal folliculus ovaricus primarius morphology" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0009363
name: abnormal tertiary ovarian follicle morphology
def: "any structural anomaly in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [https://orcid.org/0000-0002-6490-7723, UBERON:0000037]
synonym: "abnormal antral follicle morphology" EXACT []
synonym: "abnormal folliculus ovaricus tertiarius morphology" EXACT []
synonym: "abnormal folliculus ovaricus vesiculosus morphology" EXACT []
synonym: "abnormal Graafian follicle morphology" EXACT []
synonym: "abnormal vesicular follicle of ovary morphology" EXACT []
synonym: "abnormal vesicular ovarian follicle morphology" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0009364
name: abnormal mature ovarian follicle morphology
def: "any structural anomaly in the ovarian follicle that is ready for ovulation and presents a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0009365
name: abnormal theca cell layer morphology
def: "any structural anomaly in the envelope of condensed connective tissue surrounding an ovarian follicle starting at the secondary follicle stage; the theca folliculi are divided into two layers, an internal vascular layer (tunica interna) and an external fibrous layer (tunica externa)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ovarian thecal cells" EXACT []
synonym: "abnormal theca folliculi morphology" EXACT []
synonym: "abnormal thecal layer morphology" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0009366
name: abnormal theca interna morphology
def: "any structural anomaly in the inner cellular and vascular layer of the theca of a secondary ovarian follicle; evidence indicates that the epithelioid cells produce androgens and contribute to the formation of the corpus luteum after ovulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal thecal layer morphology" EXACT []
synonym: "abnormal theca interna" EXACT []
synonym: "abnormal tunica interna thecae folliculi" EXACT []
is_a: MP:0009365 ! abnormal theca cell layer morphology

[Term]
id: MP:0009367
name: abnormal theca externa morphology
def: "any structural anomaly in the external fibrous layer of the theca of a secondary ovarian follicle; the theca externa contains abundant collagen and is mainly supportive" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal external thecal layer morphology" EXACT []
synonym: "abnormal theca externa" EXACT []
synonym: "abnormal tunica externa thecae folliculi" EXACT []
is_a: MP:0009365 ! abnormal theca cell layer morphology

[Term]
id: MP:0009368
name: absent theca folliculi
def: "absence of the internal, external or both layers of the sheath of stroma surrounding a secondary ovarian follicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent thecal layer formation" EXACT []
is_a: MP:0009365 ! abnormal theca cell layer morphology

[Term]
id: MP:0009369
name: abnormal theca cell number
def: "abnormal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal thecal cell number" EXACT []
is_a: MP:0009365 ! abnormal theca cell layer morphology

[Term]
id: MP:0009370
name: decreased theca cell number
def: "fewer than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased number of thecal cells" EXACT []
synonym: "decreased thecal cell number" EXACT []
synonym: "reduced thecal cell number" EXACT []
is_a: MP:0009369 ! abnormal theca cell number

[Term]
id: MP:0009371
name: increased theca cell number
def: "greater than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased number of theca cells" EXACT []
synonym: "increased number of thecal cells" EXACT []
synonym: "increased thecal cell number" EXACT []
is_a: MP:0009369 ! abnormal theca cell number

[Term]
id: MP:0009372
name: abnormal cumulus oophorus morphology
def: "atypical formation of or inability to produce a mass of epithelial granulosa cells around the oocyte in the maturing Graafian follicle; the cumulus oophorus begins to expand dramatically when cumulus cells are induced to synthesize hyaluronic acid which aggregates in a viscous intercellular matrix" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cumulus oophorous" EXACT []
synonym: "abnormal cumulus ovaricus" EXACT []
synonym: "abnormal ovigerus" EXACT []
synonym: "abnormal proligerous disc" EXACT []
synonym: "abnormal proligerous membrane" EXACT []
is_a: MP:0008868 ! abnormal granulosa cell morphology

[Term]
id: MP:0009373
name: abnormal cumulus expansion
def: "anomaly in the ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ovarian cumulus expansion" EXACT []
synonym: "abnormal ovarian cumulus growth" EXACT []
is_a: MP:0001130 ! abnormal ovarian folliculogenesis

[Term]
id: MP:0009374
name: absent cumulus expansion
def: "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ovarian cumulus growth" EXACT []
synonym: "failure of cumulus expansion" EXACT []
is_a: MP:0009373 ! abnormal cumulus expansion

[Term]
id: MP:0009375
name: thin zona pellucida
def: "reduced thickness of the solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003696 ! abnormal zona pellucida morphology

[Term]
id: MP:0009376
name: abnormal manchette morphology
def: "any structural anomaly of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006380 ! abnormal spermatid morphology

[Term]
id: MP:0009377
name: ectopic manchette
def: "abnormal position of the conic array of microtubules that normally invests the posterior nucleus of a spermatid" [https://orcid.org/0000-0002-6490-7723]
synonym: "heterotopic manchette" EXACT []
synonym: "mislocalised manchette" EXACT []
synonym: "mislocalized manchette" EXACT []
is_a: MP:0009376 ! abnormal manchette morphology

[Term]
id: MP:0009378
name: abnormal endoplasmic reticulum morphology
def: "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
comment: The endoplasmic reticulum membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
synonym: "abnormal ER morphology" EXACT []
is_a: MP:0014239 ! abnormal intracellular organelle morphology

[Term]
id: MP:0009379
name: abnormal foot pigmentation
def: "anomaly in the coloration of the foot due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:llw2, MGI:mberry]
is_a: MP:0002095 ! abnormal skin pigmentation

[Term]
id: MP:0009380
name: abnormal prostate gland ventral lobe morphology
def: "any structural anomaly of the rodent prostate lobe that is located below the ventral aspect of the bladder neck" [PMID:12645922, PMID:3308446]
comment: In rodents, the prostate gland consists of three lobes, the anterior prostate (AP; also known as the coagulating gland), the dorsolateral prostate (DLP), and the ventral prostate (VP). These lobes are arranged circumferentially around the urethra and display characteristic patterns of ductal branching and protein secretion (PMID:3308446). In contrast, the adult human prostate lacks discernible lobular organization and, instead, completely envelops the urethra at the base of the bladder (PMID:3308446).
synonym: "abnormal ventral prostate morphology" EXACT []
synonym: "abnormal VP morphology" EXACT []
xref: MA:0001740
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0009381
name: abnormal prostate gland dorsolateral lobe morphology
def: "any structural anomaly of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [PMID:12645922, PMID:3308446]
comment: In rodents, the prostate gland consists of three lobes, the anterior prostate (AP; also known as the coagulating gland), the dorsolateral prostate (DLP), and the ventral prostate (VP). These lobes are arranged circumferentially around the urethra and display characteristic patterns of ductal branching and protein secretion (PMID:3308446). In contrast, the adult human prostate lacks discernible lobular organization and, instead, completely envelops the urethra at the base of the bladder (PMID:3308446).
synonym: "abnormal DLP morphology" EXACT []
synonym: "abnormal dorsolateral prostate morphology" EXACT []
xref: MA:0001739
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0009382
name: abnormal cardiac jelly morphology
def: "any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000267 ! abnormal heart development

[Term]
id: MP:0009383
name: obsolete abnormal truncus arteriosus morphology
def: "OBSOLETE. any structural anomaly of the common arterial trunk opening out of both ventricles that divides into the aorta and pulmonary artery during development" [https://orcid.org/0000-0003-4606-0597]
is_obsolete: true

[Term]
id: MP:0009384
name: cardiac valve regurgitation
def: "the backward reflux of blood through a cardiac valve, due to insufficiency caused by disease, aging or congenital malformation" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiac valve insufficiency" EXACT []
is_a: MP:0011926 ! abnormal heart valve physiology

[Term]
id: MP:0009385
name: abnormal dermal pigmentation
def: "anomaly in the coloration of the dermal layer of the skin due to changes in the amount, shape, or distribution of cells producing pigment" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
is_a: MP:0002095 ! abnormal skin pigmentation

[Term]
id: MP:0009386
name: abnormal dermal melanocyte morphology
def: "any structural anomaly of the cells that produce pigment in the dermis" [https://orcid.org/0000-0003-3691-0324, ISBN:978-1-4051-2034-0]
synonym: "abnormal dermal melanocytes" EXACT []
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0009385 ! abnormal dermal pigmentation

[Term]
id: MP:0009387
name: abnormal epidermal pigmentation
def: "anomaly in the coloration of the epidermal layer of the skin due to changes in the amount, shape, or distribution of cells producing pigment" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002095 ! abnormal skin pigmentation

[Term]
id: MP:0009388
name: abnormal epidermal melanocyte morphology
def: "any structural anomaly of the cells that produce pigment in the epidermis" [ISBN:978-1-4051-2034-0]
comment: These cells are found primarily, but not exclusively, in primates including humans.
synonym: "abnormal epidermal melanocytes" EXACT []
synonym: "abnormal interfollicular melanocyte morphology" EXACT []
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0009387 ! abnormal epidermal pigmentation

[Term]
id: MP:0009389
name: abnormal extracutaneous pigmentation
def: "anomaly in the coloration of organs and tissues excluding the integument due to changes in the amount, shape, or distribution of cells producing pigment" [ISBN:978-1-4051-2034-0]
comment: Note that significant differences exist among populations of melanocytes that populate the cutaneous tissue compared to melanocytes that populate ocular, auditory, and internal body sites. Extracutaneous melanotcytes synthesize melanosomes and melanin only during a short interval after arriving in their target tissue, and they retain their melanosomes throughout the life of the organism instead of transferring to neighboring cells like dermal melanocytes. General morphology and ultrastructure of extracutaneous melanocytes vary and also differ from cutaneous melanocytes.
is_a: MP:0001186 ! pigmentation phenotype

[Term]
id: MP:0009390
name: abnormal otic pigmentation
def: "any anomaly in the pigment or pigment-producing cells of the inner ear resulting in abnormal melanoblast numbers, distribution, or pigment during development" [ISBN:978-1-4051-2034-0]
synonym: "abnormal auditory pigmentation" EXACT []
synonym: "abnormal inner ear pigmentation" EXACT []
is_a: MP:0009389 ! abnormal extracutaneous pigmentation

[Term]
id: MP:0009391
name: abnormal leptomeninges pigmentation
def: "any anomaly in the coloring of the two innermost layers of the meninges, including the pia mater and the arachnoid, due to changes in the amount, shape, or distribution of cells producing pigment" [ISBN:978-1-4051-2034-0, MGI:llw2]
is_a: MP:0009389 ! abnormal extracutaneous pigmentation

[Term]
id: MP:0009392
name: retina gliosis
def: "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "retinal gliosis" EXACT []
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0009393
name: abnormal resting posture
def: "atypical intentionally or habitually assumed position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2]
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0009394
name: increased uterine NK cell number
def: "increased cell number of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy" [PMID:14568979, PMID:19800965]
synonym: "increased decidual natural killer cell number" EXACT []
synonym: "increased decidual NK cell number" EXACT []
synonym: "increased dNK cell number" EXACT []
synonym: "increased GMG cell number" EXACT []
synonym: "increased granulated metrial gland cell number" EXACT []
synonym: "increased uNK cell number" EXACT []
synonym: "increased uterine natural killer cell number" EXACT []
xref: CL:0002343
is_a: MP:0008044 ! increased NK cell number
is_a: MP:0008054 ! abnormal uterine NK cell morphology

[Term]
id: MP:0009395
name: increased nucleated erythrocyte cell number
def: "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased immature erythrocyte cell number" EXACT []
synonym: "increased immature RBC cell number" RELATED []
synonym: "increased immature red blood cell number" RELATED []
synonym: "increased nucleated RBC cell number" RELATED []
synonym: "increased nucleated red blood cell number" RELATED []
synonym: "persistence of embryonic erythrocytes" NARROW []
synonym: "persistence of primitive erythrocytes" NARROW []
is_a: MP:0012397 ! abnormal nucleated erythrocyte cell number

[Term]
id: MP:0009396
name: small endometrial glands
def: "decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased endometrial gland size" EXACT []
synonym: "small glandulae uterinae" EXACT []
synonym: "small uterine glands" EXACT []
is_a: MP:0009094 ! abnormal endometrial gland morphology

[Term]
id: MP:0009397
name: increased trophoblast giant cell number
def: "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005033 ! abnormal trophoblast giant cell morphology

[Term]
id: MP:0009398
name: abnormal skeletal muscle fiber size
def: "anomaly in the size of the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal skeletal muscle fibre size" EXACT []
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology

[Term]
id: MP:0009399
name: increased skeletal muscle fiber size
alt_id: MP:0003399
def: "increase in the size of the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased skeletal muscle fibre size" EXACT []
synonym: "skeletal muscle fiber hypertrophy" EXACT []
synonym: "skeletal muscle fibre hypertrophy" EXACT []
is_a: MP:0009398 ! abnormal skeletal muscle fiber size

[Term]
id: MP:0009400
name: decreased skeletal muscle fiber size
def: "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased skeletal muscle fibre size" EXACT []
synonym: "reduced skeletal muscle fiber size" EXACT []
synonym: "reduced skeletal muscle fibre size" EXACT []
is_a: MP:0009398 ! abnormal skeletal muscle fiber size

[Term]
id: MP:0009401
name: increased skeletal muscle fiber diameter
def: "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009399 ! increased skeletal muscle fiber size

[Term]
id: MP:0009402
name: decreased skeletal muscle fiber diameter
def: "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skeletal muscle fibre diameter" EXACT []
synonym: "reduced skeletal muscle fiber diameter" EXACT []
synonym: "reduced skeletal muscle fibre diameter" EXACT []
is_a: MP:0009400 ! decreased skeletal muscle fiber size

[Term]
id: MP:0009403
name: increased variability of skeletal muscle fiber size
def: "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009398 ! abnormal skeletal muscle fiber size

[Term]
id: MP:0009404
name: centrally nucleated skeletal muscle fibers
def: "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [https://orcid.org/0000-0003-3691-0324]
synonym: "centrally localized nuclei in skeletal muscle fibers" EXACT []
synonym: "centrally localized nuclei in skeletal muscle fibres" EXACT []
synonym: "centrally nucleated skeletal muscle fibres" EXACT []
synonym: "centronuclear myopathy" BROAD []
synonym: "nuclear rowing in muscle" EXACT []
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology

[Term]
id: MP:0009405
name: increased skeletal muscle fiber number
def: "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology

[Term]
id: MP:0009406
name: decreased skeletal muscle fiber number
def: "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology

[Term]
id: MP:0009407
name: increased skeletal muscle fiber density
def: "increase in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0009408
name: decreased skeletal muscle fiber density
def: "decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skeletal muscle fibre density" EXACT []
synonym: "reduced skeletal muscle fiber density" EXACT []
synonym: "reduced skeletal muscle fibre density" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0009409
name: abnormal skeletal muscle fiber type ratio
def: "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skeletal muscle fiber distribution" EXACT []
synonym: "abnormal skeletal muscle fibre distribution" EXACT []
synonym: "abnormal skeletal muscle fibre type ratio" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0009410
name: abnormal skeletal muscle satellite cell proliferation
def: "anomaly in the ability of the elongated, spindle-shaped cells located between the basal lamina and the plasmalemma of a muscle fiber to undergo expansion by cell division, usually triggered by injury or disease; these cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers" [CL:0000594, https://orcid.org/0000-0002-6490-7723]
comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle satellite cell population.
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0009411
name: abnormal skeletal muscle fiber triad morphology
def: "any structural anomaly of the skeletal muscle fiber structure comprised of the transverse tubule and the two associated terminal cisternae; each fiber normally has thousands of triads" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology

[Term]
id: MP:0009412
name: skeletal muscle fiber degeneration
def: "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [https://orcid.org/0000-0003-3691-0324]
synonym: "skeletal muscle fibre degeneration" EXACT []
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology
is_a: MP:0009415 ! skeletal muscle degeneration

[Term]
id: MP:0009413
name: skeletal muscle fiber atrophy
def: "acquired diminution of the size of skeletal muscle fibers associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009400 ! decreased skeletal muscle fiber size
is_a: MP:0009417 ! skeletal muscle atrophy

[Term]
id: MP:0009414
name: skeletal muscle fiber necrosis
def: "morphological changes resulting from pathological death of skeletal muscle fiber tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic skeletal muscle fiber" EXACT []
synonym: "necrotic skeletal muscle fibers" EXACT []
synonym: "necrotic skeletal muscle fibre" EXACT []
synonym: "necrotic skeletal muscle fibres" EXACT []
synonym: "skeletal muscle fibre necrosis" EXACT []
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology
is_a: MP:0003852 ! skeletal muscle necrosis

[Term]
id: MP:0009415
name: skeletal muscle degeneration
def: "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000749 ! muscle degeneration
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0009416
name: cardiac muscle degeneration
def: "pathological deterioration of cardiac muscle tissue, often accompanied by loss of function" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000749 ! muscle degeneration
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology

[Term]
id: MP:0009417
name: skeletal muscle atrophy
def: "acquired diminution of the size of skeletal muscle tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002269 ! muscular atrophy
is_a: MP:0010240 ! decreased skeletal muscle size

[Term]
id: MP:0009418
name: cardiac muscle atrophy
def: "acquired diminution of cardiac muscle tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002269 ! muscular atrophy
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology

[Term]
id: MP:0009419
name: skeletal muscle fibrosis
def: "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0009420
name: skeletal muscle endomysial fibrosis
def: "replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009419 ! skeletal muscle fibrosis

[Term]
id: MP:0009421
name: increased gastrocnemius weight
def: "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8]
is_a: MP:0013188 ! abnormal gastrocnemius weight

[Term]
id: MP:0009422
name: decreased gastrocnemius weight
def: "reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8]
synonym: "reduced gastrocnemius weight" RELATED []
is_a: MP:0013188 ! abnormal gastrocnemius weight

[Term]
id: MP:0009423
name: increased extensor digitorum longus weight
def: "increase in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased EDL weight" EXACT []
is_a: MP:0012783 ! abnormal extensor digitorum longus weight

[Term]
id: MP:0009424
name: decreased extensor digitorum longus weight
def: "reduction in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased EDL weight" EXACT []
synonym: "reduced EDL weight" EXACT []
synonym: "reduced extensor digitorum longus weight" EXACT []
is_a: MP:0012783 ! abnormal extensor digitorum longus weight

[Term]
id: MP:0009425
name: increased soleus weight
def: "increase in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020165 ! abnormal soleus weight

[Term]
id: MP:0009426
name: decreased soleus weight
def: "reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced soleus weight" EXACT []
is_a: MP:0020165 ! abnormal soleus weight

[Term]
id: MP:0009427
name: increased tibialis anterior weight
def: "increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased TA weight" EXACT []
is_a: MP:0020166 ! abnormal tibialis anterior weight

[Term]
id: MP:0009428
name: decreased tibialis anterior weight
def: "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased TA weight" EXACT []
synonym: "reduced TA weight" EXACT []
synonym: "reduced tibialis anterior weight" EXACT []
is_a: MP:0020166 ! abnormal tibialis anterior weight

[Term]
id: MP:0009429
name: decreased embryo weight
def: "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced embryo weight" EXACT []
is_a: MP:0001698 ! decreased embryo size

[Term]
id: MP:0009430
name: increased embryo weight
def: "increase in the weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001699 ! increased embryo size

[Term]
id: MP:0009431
name: decreased fetal weight
def: "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased foetal weight" EXACT []
synonym: "reduced fetal weight" EXACT []
synonym: "reduced foetal weight" EXACT []
is_a: MP:0004200 ! decreased fetal size

[Term]
id: MP:0009432
name: increased fetal weight
def: "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased foetal weight" EXACT []
is_a: MP:0004199 ! increased fetal size

[Term]
id: MP:0009433
name: polyovular ovarian follicle
def: "an ovarian follicle containing more than one oocyte (ovum)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001131 ! abnormal ovarian follicle morphology

[Term]
id: MP:0009434
name: paraparesis
def: "a weakness affecting both lower or hind limbs" [MGI:llw2]
is_a: MP:0031204 ! hindlimb paresis

[Term]
id: MP:0009435
name: abnormal miniature inhibitory postsynaptic currents
def: "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal miniature inhibitory post-synaptic currents" EXACT []
synonym: "abnormal mIPSCs" EXACT []
synonym: "abnormal sIPSCs" EXACT []
synonym: "abnormal spontaneous inhibitory post-synaptic currents" EXACT []
synonym: "abnormal spontaneous inhibitory postsynaptic currents" EXACT []
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0009436
name: fragmentation of sleep/wake states
def: "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
is_a: MP:0001501 ! abnormal sleep pattern

[Term]
id: MP:0009437
name: arytenoid and cricoid cartilage fusion
def: "union of the arytenoid and cricoid cartilages into one structure, when this fusion does not normally occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "fused arytenoid and cricoid cartilages" EXACT []
synonym: "fusion of arytenoid and cricoid cartilages" EXACT []
is_a: MP:0002257 ! abnormal arytenoid cartilage morphology
is_a: MP:0002258 ! abnormal cricoid cartilage morphology

[Term]
id: MP:0009438
name: cricoid and tracheal cartilage fusion
def: "union of the cricoid cartilage and one or more of the tracheal rings into one structure, when this fusion does not normally occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "fused cricoid and tracheal cartilages" EXACT []
synonym: "fusion of cricoid and tracheal cartilages" EXACT []
is_a: MP:0002258 ! abnormal cricoid cartilage morphology
is_a: MP:0003120 ! abnormal tracheal cartilage morphology

[Term]
id: MP:0009439
name: increased myeloid sarcoma incidence
def: "higher than normal incidence of a malignant tumor of immature myeloid cells, often associated with or preceeding granulocytic leukemia" [ISBN:0-683-40008-8]
synonym: "EMMT" RELATED []
synonym: "extramedullary myeloid tumors" RELATED []
synonym: "extramedullary myeloid tumours" RELATED []
synonym: "granulocytic sarcoma" RELATED []
synonym: "myeloid sarcoma" RELATED []
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence
is_a: MP:0010354 ! increased odontosarcoma incidence

[Term]
id: MP:0009440
name: increased myeloma incidence
def: "higher than normal incidence of a bone marrow cancer in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body" [DOID:0070004, ISBN:0-683-40008-8]
synonym: "myeloma" RELATED []
synonym: "plasma cell tumor" RELATED []
synonym: "plasma cell tumour" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence

[Term]
id: MP:0009441
name: delayed skin barrier formation
def: "slowed progression in the establishment of the ability of the skin to regulate water loss" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003941 ! abnormal skin development

[Term]
id: MP:0009442
name: increased ovarian teratoma incidence
def: "greater than the expected number of a usually benign tumor found in the ovary, occurring in a specific population in a given time period; ovarian teratomas are typically the result of an anomaly of oogenesis and typically contains a diversity of tissues often representing all organ systems e.g. hair, teeth, bone, thyroid, nerve tissue" [MGI:llw2]
synonym: "ovarian dermoid cyst" RELATED []
synonym: "ovarian teratoma" RELATED []
is_a: MP:0002627 ! increased teratoma incidence
is_a: MP:0008000 ! increased ovary tumor incidence

[Term]
id: MP:0009443
name: parthenogenesis
def: "development of an egg into a diploid embryo without being fertilized" [MGI:llw2]
synonym: "parthenogenetic embryo" EXACT []
synonym: "unigenesis" EXACT []
is_a: MP:0005168 ! abnormal female meiosis

[Term]
id: MP:0009444
name: ovarian follicular cyst
def: "presence of one or more fluid-filled membranous sacs arising when ovarian follicles fail to rupture during ovulation" [MGI:llw2]
synonym: "cystic ovarian follicle" EXACT []
synonym: "cystic ovarian follicles" EXACT []
synonym: "ovarian follicular cysts" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology
is_a: MP:0002016 ! ovary cyst

[Term]
id: MP:0009445
name: osteomalacia
def: "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [https://orcid.org/0000-0002-6490-7723]
synonym: "adult rickets" EXACT []
synonym: "increased osteoid amount" RELATED []
synonym: "late rickets" EXACT []
synonym: "rachitis tarda" EXACT []
is_a: MP:0002896 ! abnormal bone mineralization

[Term]
id: MP:0009446
name: abnormal platelet dense granule physiology
def: "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2]
synonym: "abnormal delta granule physiology" EXACT []
synonym: "abnormal dense body physiology" EXACT []
is_a: MP:0005464 ! abnormal platelet physiology

[Term]
id: MP:0009447
name: abnormal platelet ATP level
def: "anomaly in the amount of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2]
synonym: "abnormal platelet adenosine triphosphate level" EXACT []
is_a: MP:0004721 ! abnormal platelet dense granule morphology
is_a: MP:0014244 ! abnormal cellular ATP level

[Term]
id: MP:0009448
name: decreased platelet ATP level
def: "reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2]
synonym: "decreased platelet adenosine triphosphate level" EXACT []
synonym: "reduced platelet ATP level" EXACT []
is_a: MP:0009447 ! abnormal platelet ATP level
is_a: MP:0014246 ! decreased cellular ATP level

[Term]
id: MP:0009449
name: increased platelet ATP level
def: "increased concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2]
synonym: "increased platelet adenosine triphosphate level" EXACT []
is_a: MP:0009447 ! abnormal platelet ATP level
is_a: MP:0014245 ! increased cellular ATP level

[Term]
id: MP:0009450
name: abnormal axon fasciculation
def: "anomaly in the process by which axons form into nerve fiber bundles" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fasciculation of neuron axon" EXACT []
xref: GO:0007413
is_a: MP:0009937 ! abnormal neuron differentiation

[Term]
id: MP:0009451
name: abnormal chromosomal synapsis
def: "any anomaly in the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during prophase I of meiosis; synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete" []
synonym: "abnormal chromosomal pairing" RELATED []
synonym: "abnormal chromosomal syndesis" EXACT []
synonym: "abnormal chromosome pairing" RELATED []
synonym: "abnormal chromosome pairing during meiosis" EXACT []
synonym: "abnormal homologous chromosome pairing at meiosis" EXACT []
synonym: "abnormal meiotic chromosome synapsis" EXACT []
xref: GO:0007129
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009452
name: abnormal synaptonemal complex
def: "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009453
name: enhanced contextual conditioning behavior
def: "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced contextual fear conditioning" EXACT []
is_a: MP:0001469 ! abnormal contextual conditioning behavior
is_a: MP:0012316 ! enhanced conditioning behavior

[Term]
id: MP:0009454
name: impaired contextual conditioning behavior
def: "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [https://orcid.org/0000-0003-4606-0597]
synonym: "impaired contextual fear conditioning" EXACT []
is_a: MP:0001469 ! abnormal contextual conditioning behavior
is_a: MP:0012317 ! impaired conditioning behavior

[Term]
id: MP:0009455
name: enhanced cued conditioning behavior
def: "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced cued conditioning behaviour" EXACT []
synonym: "enhanced cued fear conditioning" EXACT []
synonym: "increased cued conditioning behavior" EXACT []
is_a: MP:0001454 ! abnormal cued conditioning behavior
is_a: MP:0012316 ! enhanced conditioning behavior

[Term]
id: MP:0009456
name: impaired cued conditioning behavior
def: "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cued conditioning behavior" EXACT []
synonym: "impaired cued conditioning behaviour" EXACT []
synonym: "impaired cued fear conditioning" EXACT []
is_a: MP:0001454 ! abnormal cued conditioning behavior
is_a: MP:0012317 ! impaired conditioning behavior

[Term]
id: MP:0009457
name: whorled hair
def: "an area of hair growing opposite in direction to the rest of the hair, a curl or swirl" [MGI:llw2]
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0009458
name: abnormal skeletal muscle size
def: "anomaly in the size of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8, MGI:llw2]
is_a: MP:0004817 ! abnormal skeletal muscle mass

[Term]
id: MP:0009459
name: skeletal muscle hyperplasia
def: "increase in the number of normal cells in normal arrangement in the skeletal muscle, typically resulting in increased size" [MGI:llw2]
synonym: "hyperplastic skeletal muscle" EXACT []
is_a: MP:0003398 ! increased skeletal muscle size

[Term]
id: MP:0009460
name: skeletal muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the skeletal muscle, typically resulting in decreased size" [MGI:llw2]
synonym: "hypoplastic skeletal muscle" EXACT []
is_a: MP:0000734 ! muscle hypoplasia
is_a: MP:0010240 ! decreased skeletal muscle size

[Term]
id: MP:0009461
name: skeletal muscle hypertrophy
def: "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2]
is_a: MP:0003398 ! increased skeletal muscle size

[Term]
id: MP:0009462
name: skeletal muscle hypotrophy
def: "decrease in the bulk size of the skeletal muscle due to cell shrinkage" [MGI:llw2]
is_a: MP:0010240 ! decreased skeletal muscle size

[Term]
id: MP:0009463
name: abnormal pituitary infundibular stalk morphology
def: "any structural anomaly of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [ISBN:0-683-40008-8]
synonym: "abnormal hypophyseal stalk" EXACT []
synonym: "abnormal infundibular stem morphology" EXACT []
synonym: "abnormal pituitary infundibulum" EXACT []
synonym: "abnormal pituitary stalk morphology" EXACT []
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0009465
name: abnormal gallbladder infundibulum morphology
def: "any structural anomaly of the tapering portion of the gall bladder that narrows to form the neck and cystic duct" [ISBN:0-683-40008-8]
synonym: "abnormal gall bladder infundibulum morphology" EXACT []
synonym: "abnormal infundibulum of gallbladder" EXACT []
synonym: "abnormal infundibulum vesicae biliaris" EXACT []
is_a: MP:0005084 ! abnormal gallbladder morphology

[Term]
id: MP:0009466
name: abnormal uterine tube infundibulum morphology
def: "any structural anomaly of the funnel-like expansion of the abdominal extremity of the uterine tube" [ISBN:0-683-40008-8]
synonym: "abnormal infundibulum of uterine tube" EXACT []
is_a: MP:0003574 ! abnormal oviduct morphology

[Term]
id: MP:0009467
name: abnormal magnocellular neurosecretory cell morphology
def: "any structural anomaly of the cells residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, and secrete the hormones oxytocin and vasopressin" [PMID:10711808]
synonym: "abnormal magnocellular neuron morphology" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology

[Term]
id: MP:0009468
name: absent magnocellular neurosecretory cells
def: "absence of the cells residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, and secrete the hormones oxytocin and vasopressin" [PMID:10711808]
is_a: MP:0009467 ! abnormal magnocellular neurosecretory cell morphology

[Term]
id: MP:0009469
name: increased skin hamartoma incidence
def: "greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the skin, but composed of an overgrowth of mature cells and tissues that normally occur in this tissue, occurring in a specific population in a given time period" [MGI:llw2]
synonym: "skin hamartoma" RELATED []
is_a: MP:0010300 ! increased skin tumor incidence
is_a: MP:0010306 ! increased hamartoma incidence

[Term]
id: MP:0009470
name: mirror image duplication
def: "during embryogenesis a second structure develops with its parts arranged in a reversal of right and left orientation" [MGI:llw2]
is_a: MP:0002084 ! abnormal developmental patterning

[Term]
id: MP:0009471
name: abnormal urine sulfate level
def: "any change in the amount of sulfate in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urine sulphate level" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0009472
name: increased urine sulfate level
def: "an increase in amount of sulfates in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypersulfaturia" EXACT []
synonym: "hypersulphaturia" EXACT []
synonym: "increased urine sulphate level" EXACT []
is_a: MP:0009471 ! abnormal urine sulfate level

[Term]
id: MP:0009473
name: abnormal skin exfoliation
def: "anomaly in the process of detachment and shedding of superficial cells of a skin epithelium" [MGI:llw2]
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0009474
name: thick epidermis stratum spinosum
def: "increased thickness of the stratum spinosum; the polyhedral cell layer" [MGI:llw2]
synonym: "thick epidermal spinous layer" EXACT []
synonym: "thick prickle cell layer" EXACT []
synonym: "thick spinous layer" EXACT []
synonym: "thick stratum spinosum" EXACT []
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0009475
name: abnormal nicotine-mediated receptor currents
def: "change in the measured amplitude, current density or duration of response to stimulation of nicotinic receptors" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
is_a: MP:0002206 ! abnormal CNS synaptic transmission

[Term]
id: MP:0009476
name: enlarged cecum
def: "increased size of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged caecum" EXACT []
synonym: "increased cecum size" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009477
name: small cecum
def: "reduced size of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cecum size" EXACT []
synonym: "reduced caecum size" EXACT []
synonym: "reduced cecum size" EXACT []
synonym: "small caecum" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009478
name: coiled cecum
def: "corkscrew or worm-like appearance of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "coiled caecum" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009479
name: abnormal cecum development
def: "malformation or aberrant differentiation of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal caecum development" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009480
name: distended cecum
def: "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated caecum" EXACT []
synonym: "dilated cecum" EXACT []
synonym: "swollen caecum" EXACT []
synonym: "swollen cecum" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009481
name: cecum inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [https://orcid.org/0000-0002-6490-7723]
synonym: "caecum inflammation" EXACT []
synonym: "cecitis" EXACT []
synonym: "typhlenteritis" EXACT []
synonym: "typhlitis" EXACT []
synonym: "typhloenteritis" EXACT []
is_a: MP:0003304 ! large intestinal inflammation

[Term]
id: MP:0009482
name: ileum inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "ileitis" EXACT []
is_a: MP:0003306 ! small intestinal inflammation

[Term]
id: MP:0009483
name: enlarged ileum
def: "increased size of the portion of the small intestine that extends from the jejunum to the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased ileum size" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology

[Term]
id: MP:0009484
name: ileum hypertrophy
def: "an increase in the bulk size of the portion of the small intestine that extends from the jejunum to the colon due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "ileal hypertrophy" EXACT []
is_a: MP:0009483 ! enlarged ileum

[Term]
id: MP:0009485
name: distended ileum
def: "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated ileum" EXACT []
synonym: "ileal distension" EXACT []
synonym: "mega-ileum" EXACT []
synonym: "swollen ileum" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology

[Term]
id: MP:0009486
name: rectovaginal fusion
def: "fusion of the rectum and vaginal canals" [MGI:mberry]
synonym: "recto-vaginal fusion" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
is_a: MP:0001139 ! abnormal vagina morphology

[Term]
id: MP:0009487
name: rectourethral fusion
def: "fusion of the rectum and urethral canals" [MGI:mberry]
synonym: "recto-urethral fusion" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
is_a: MP:0000537 ! abnormal urethra morphology

[Term]
id: MP:0009488
name: abnormal pancreatic islet cell apoptosis
def: "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002693 ! abnormal pancreas physiology

[Term]
id: MP:0009489
name: abnormal blood vessel endothelium morphology
def: "any structural anomaly of the thin layer of flat cells that line the blood vessels and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [ISBN:0-683-40008-8]
xref: MA:0000709
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0009490
name: abnormal heart left atrium auricular region morphology
def: "any structural anomaly of the small conical pouch projections located on the upper anterior portion of the left atrium of the heart" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal auricula atrii sinistra morphology" EXACT []
synonym: "abnormal LAA morphology" EXACT []
synonym: "abnormal left atrial appendage morphology" EXACT []
synonym: "abnormal left auricle morphology" EXACT []
synonym: "abnormal left auricular appendage morphology" EXACT []
synonym: "abnormal left auricular appendix morphology" EXACT []
is_a: MP:0003923 ! abnormal heart left atrium morphology
is_a: MP:0010489 ! abnormal heart atrium auricular region morphology

[Term]
id: MP:0009491
name: abnormal heart right atrium auricular region morphology
def: "any structural anomaly of the small conical pouch projections located on the upper anterior portion of the right atrium of the heart" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal RAA morphology" EXACT []
synonym: "abnormal right atrial appendage morphology" EXACT []
synonym: "abnormal right auricle morphology" EXACT []
synonym: "abnormal right auricula morphology" EXACT []
synonym: "abnormal right auricular appendix morphology" EXACT []
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0010489 ! abnormal heart atrium auricular region morphology

[Term]
id: MP:0009492
name: abnormal gallbladder epithelium morphology
def: "any structural anomaly of the simple columnar epithelial lining of the gall bladder" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gall bladder epithelium morphology" EXACT []
is_a: MP:0005084 ! abnormal gallbladder morphology

[Term]
id: MP:0009493
name: abnormal cystic duct morphology
def: "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8]
synonym: "abnormal cystic gall duct morphology" EXACT []
synonym: "abnormal ductus cysticus morphology" EXACT []
is_a: MP:0005084 ! abnormal gallbladder morphology
is_a: MP:0009498 ! abnormal extrahepatic bile duct morphology

[Term]
id: MP:0009494
name: abnormal biliary ductule morphology
def: "any structural anomaly of the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct" [ISBN:0-683-40008-8]
synonym: "abnormal cannalicular ductule morphology" EXACT []
synonym: "abnormal ductuli biliferi" EXACT []
synonym: "abnormal intrahepatic bile duct morphology" BROAD []
is_a: MP:0009497 ! abnormal intrahepatic bile duct morphology

[Term]
id: MP:0009495
name: abnormal common bile duct morphology
def: "any structural anomaly of the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal choledoch duct" EXACT []
synonym: "abnormal ductus choledochus" EXACT []
is_a: MP:0009498 ! abnormal extrahepatic bile duct morphology

[Term]
id: MP:0009496
name: abnormal common hepatic duct morphology
def: "any structural anomaly of the part of the biliary tree formed by the union of the right and left hepatic ducts, and joins the cystic duct to form the common bile duct" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ductus hepaticus communis" EXACT []
synonym: "anbormal hepatocystic duct morphology" EXACT []
is_a: MP:0009498 ! abnormal extrahepatic bile duct morphology

[Term]
id: MP:0009497
name: abnormal intrahepatic bile duct morphology
def: "any structural anomaly of the passages within the liver for the conveyance of bile" [MESH:A03.159.183.158]
synonym: "abnormal intrahepatic biliary system morphology" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0009498
name: abnormal extrahepatic bile duct morphology
def: "any structural anomaly of the passages external to the liver for the conveyance of bile" [MESH:A03.159.183.079]
synonym: "abnormal extrahepatic biliary system morphology" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0009499
name: abnormal intralobular bile duct morphology
def: "any structural anomaly of the tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal canal of Hering" EXACT []
synonym: "abnormal intrahepatic bile ductule morphology" EXACT []
is_a: MP:0008987 ! abnormal liver lobule morphology
is_a: MP:0009497 ! abnormal intrahepatic bile duct morphology

[Term]
id: MP:0009500
name: abnormal interlobular bile duct morphology
def: "any structural anomaly of the canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal interlobular ductule morphology" EXACT []
is_a: MP:0008993 ! abnormal portal triad morphology
is_a: MP:0009497 ! abnormal intrahepatic bile duct morphology

[Term]
id: MP:0009501
name: abnormal hepatic duct morphology
def: "any structural anomaly of the two canals (left and right) that collect and drain bile from the left and right half of the liver from the biliary ductules and join external to the liver to form the common hepatic duct" [https://orcid.org/0000-0003-3691-0324]
comment: Note that part of the hepatic ducts are located within the liver and part is extrahepatic.
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0009502
name: abnormal areola morphology
def: "any structural anomaly of the circular pigmented region of the breast that surrounds the nipple and delineates the area containing the areolar glands" [ISBN:0-683-40008-8]
synonym: "abnormal areola mammae" EXACT []
synonym: "abnormal areola of nipple" EXACT []
synonym: "abnormal areola papillaris" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0009503
name: abnormal mammary gland duct morphology
def: "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal canalicular duct morphology" EXACT []
synonym: "abnormal ductus lactiferi morphology" EXACT []
synonym: "abnormal galactophore morphology" EXACT []
synonym: "abnormal galactophorus canal morphology" EXACT []
synonym: "abnormal galactophorus duct morphology" EXACT []
synonym: "abnormal lactiferous duct morphology" EXACT []
synonym: "abnormal mammary duct morphology" EXACT []
synonym: "abnormal mammilary duct morphology" EXACT []
synonym: "abnormal milk duct morphology" EXACT []
synonym: "abnormal tubuli galactophori morphology" EXACT []
synonym: "abnormal tubuli lactiferi" EXACT []
is_a: MP:0009504 ! abnormal mammary gland epithelium morphology

[Term]
id: MP:0009504
name: abnormal mammary gland epithelium morphology
def: "any structural anomaly of the mammary gland epithelium which is normally enveloped by a basement membrane, embedded into fatty connective tissue stroma, and organized as a bilayer, with an inner luminal layer of secretory epithelial cells, and an outer basal layer; each cell layer expresses specific molecular markers; luminal epithelial cells are characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin, whereas basal cells (aka myoepithelial cells) express smooth muscle contractile proteins; in functionally differentiated mammary gland, during lactation, luminal cells produce milk, whereas myoepithelial cells are contractile and serve for milk expulsion" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0009505
name: abnormal mammary gland lobule morphology
def: "any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0009506
name: abnormal mammary gland alveolus morphology
def: "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mammary gland alveolar morphology" EXACT []
synonym: "abnormal mammary gland alveoli" EXACT []
is_a: MP:0009505 ! abnormal mammary gland lobule morphology

[Term]
id: MP:0009507
name: abnormal mammary gland connective tissue morphology
def: "any structural anomaly of the fibrous supportive tissue of the mammary gland" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0009508
name: increased mammary gland ductal carcinoma incidence
def: "higher than normal incidence of malignant tumors of the ducts of the mammary gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "ductal carcinoma in situ" RELATED []
synonym: "mammary gland ductal carcinoma" RELATED []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0010299 ! increased mammary gland tumor incidence

[Term]
id: MP:0009509
name: absent rectum
def: "absence or loss of the terminal portion of the intestinal tube adjacent to the anus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000492 ! abnormal rectum morphology

[Term]
id: MP:0009510
name: cecal atresia
def: "congenital blockage or absence of the lumen of the cecum" [https://orcid.org/0000-0002-6490-7723]
synonym: "caecum atresia" EXACT []
synonym: "cecum atresia" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology

[Term]
id: MP:0009511
name: distended stomach
def: "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated stomach" EXACT []
synonym: "gastric distension" EXACT []
synonym: "swollen stomach" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0009512
name: abnormal cerebellar Golgi cell morphology
def: "any structural anomaly of the population of large inhibitory GABAergic interneurons found in the cerebellar internal granule layer which act by altering the mossy fibre - granule cell synapse; the main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus, which is composed of the mossy fibre terminal, granule cell dendrites, and golgi terminal and is enclosed by a glial coat" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi cell" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology

[Term]
id: MP:0009514
name: titubation
def: "posture distinguished by a faltering gait while walking and/or a swaying motion of the trunk or head while resting; often is a characteristic of cellebellar disease" [MGI:llw2]
is_a: MP:0001504 ! abnormal posture

[Term]
id: MP:0009515
name: increased gastrointestinal stromal tumor incidence
def: "higher than normal incidence of non-epithelial, mesenchymal tumors of the gastrointestinal tract, thought to originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract; approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum; GISTs are tumors of connective tissue, i.e. sarcomas, account for 1-3% of all gastrointestinal malignancies in human, and are typically more cellular than other gastrointestinal sarcomas" [http://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor, https://orcid.org/0000-0002-6490-7723, MIM:606764]
synonym: "gastrointestinal stromal tumor" RELATED []
synonym: "gastrointestinal stromal tumour" RELATED []
synonym: "GISTs" RELATED []
synonym: "increased gastrointestinal stromal tumour incidence" EXACT []
is_a: MP:0010279 ! increased gastrointestinal tumor incidence

[Term]
id: MP:0009516
name: enlarged salivary gland
def: "increased size of the saliva-secreting glands of the oral cavity" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased salivary gland size" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0009517
name: abnormal salivary gland duct morphology
def: "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8]
synonym: "abnormal striated duct morphology" NARROW []
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0009518
name: abnormal anterior lingual gland morphology
def: "any structural anomaly of the small glands located near the apex of the tongue on either side of the frenulum" [ISBN:0-683-40008-8]
synonym: "abnormal apical gland morphology" EXACT []
synonym: "abnormal Bauhin gland morphology" EXACT []
synonym: "abnormal Blandin gland morphology" EXACT []
synonym: "abnormal glandula lingualis anterior morphology" EXACT []
synonym: "abnormal lingual gland morphology" EXACT []
synonym: "abnormal Nuhn gland morphology" EXACT []
is_a: MP:0003791 ! abnormal minor salivary gland morphology
is_a: MP:0014032 ! abnormal mucous gland morphology

[Term]
id: MP:0009519
name: abnormal anterior buccal gland morphology
def: "any structural anomaly of the racemose, mucous or serous glands in the submucous tissue of the cheeks" [ISBN:0-683-40008-8]
synonym: "abnormal buccal gland morphology" EXACT []
synonym: "abnormal genal gland morphology" EXACT []
synonym: "abnormal glanduale buccales morphology" EXACT []
is_a: MP:0003745 ! abnormal oral mucosa morphology
is_a: MP:0003791 ! abnormal minor salivary gland morphology
is_a: MP:0030246 ! abnormal cheek morphology

[Term]
id: MP:0009520
name: decreased submandibular gland size
def: "reduced size of either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased maxillary gland size" EXACT []
synonym: "decreased submaxillary gland size" EXACT []
synonym: "reduced submandibular gland size" EXACT []
synonym: "reduced submaxillary gland size" EXACT []
synonym: "small maxillary gland" EXACT []
synonym: "small submandibular gland" EXACT []
synonym: "small submaxillary gland" EXACT []
is_a: MP:0003793 ! abnormal submandibular gland morphology

[Term]
id: MP:0009521
name: increased submandibular gland size
def: "increased size of either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged maxillary gland" EXACT []
synonym: "enlarged submandibular gland" EXACT []
synonym: "enlarged submaxillary gland" EXACT []
synonym: "increased maxillary gland size" EXACT []
synonym: "increased submaxillary gland size" EXACT []
is_a: MP:0003793 ! abnormal submandibular gland morphology

[Term]
id: MP:0009522
name: submandibular gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the submandibular gland, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic maxillary gland" EXACT []
synonym: "hypoplastic submandibular gland" EXACT []
synonym: "hypoplastic submaxillary gland" EXACT []
synonym: "maxillary gland hypoplasia" EXACT []
synonym: "submaxillary gland hypoplasia" EXACT []
is_a: MP:0009520 ! decreased submandibular gland size

[Term]
id: MP:0009523
name: submandibular gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the submandibular gland, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic maxillary gland" EXACT []
synonym: "hyperplastic submandibular gland" EXACT []
synonym: "hyperplastic submaxillary gland" EXACT []
synonym: "maxillary gland hyperplasia" EXACT []
synonym: "submaxillary gland hyperplasia" EXACT []
is_a: MP:0009521 ! increased submandibular gland size

[Term]
id: MP:0009524
name: absent submandibular gland
def: "absence of either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent maxillary gland" EXACT []
synonym: "absent submaxillary gland" RELATED []
is_a: MP:0003793 ! abnormal submandibular gland morphology

[Term]
id: MP:0009525
name: abnormal submandibular duct morphology
def: "any structural anomaly of the duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue" [ISBN:0-683-40008-8]
synonym: "abnormal submaxillary duct morphology" EXACT []
synonym: "abnormal Wharton duct morphology" EXACT []
synonym: "abnormal Wharton's duct morphology" EXACT []
is_a: MP:0003793 ! abnormal submandibular gland morphology
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0009526
name: absent sublingual gland
def: "absence of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent Rivinus gland" EXACT []
is_a: MP:0004035 ! abnormal sublingual gland morphology

[Term]
id: MP:0009527
name: abnormal sublingual duct morphology
def: "any structural anomaly of the canals that drain the sublingual gland" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004035 ! abnormal sublingual gland morphology
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0009528
name: abnormal major sublingual duct morphology
def: "any structural anomaly of the duct that drains the anterior portion of the sublingual gland and opens at the sublingual papilla" [ISBN:0-683-40008-8]
synonym: "abnormal Bartholin duct morphology" EXACT []
is_a: MP:0009527 ! abnormal sublingual duct morphology

[Term]
id: MP:0009529
name: abnormal minor sublingual duct morphology
def: "any structural anomaly of the 8-20 small ducts that open into the mouth on the surface of the sublingual fold" [ISBN:0-683-40008-8]
synonym: "abnormal Rivinus duct morphology" EXACT []
synonym: "abnormal Walther duct morphology" EXACT []
synonym: "abnormal Wather canal morphology" EXACT []
is_a: MP:0009527 ! abnormal sublingual duct morphology

[Term]
id: MP:0009530
name: abnormal parotid main excretory duct morphology
def: "any structural anomaly of the main excretory tubular canal that connects the parotid gland and the buccal mucosa and secretes a serous saliva into the vestibule of the oral cavity; it arises from the anterior surface of the gland, traversing the masseter muscle; the duct then pierces the buccinator muscle, moving medially, and opens out into the oral cavity near the second upper molar; saliva produced by acinar secretory cells in the glandular body flows sequentially through the intercalated ducts, striated ducts, and excretory ducts" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, http://teachmeanatomy.info/head/organs/parotid-gland/, ISBN:0-683-40008-8, PMID:23209333]
comment: The excretory ducts coalesce and form a single main excretory duct that opens into the oral cavity. Excretory ducts are interlobular.
synonym: "abnormal Blasius duct morphology" EXACT []
synonym: "abnormal parotid duct morphology" BROAD []
synonym: "abnormal Steno duct morphology" EXACT []
synonym: "abnormal Steno's duct morphology" EXACT []
synonym: "abnormal Stenon's duct morphology" EXACT []
synonym: "abnormal Stensen duct morphology" EXACT []
synonym: "abnormal Stensen's duct morphology" EXACT []
synonym: "abnormal Stenson duct morphology" EXACT []
synonym: "abnormal Stenson's duct morphology" EXACT []
is_a: MP:0013750 ! abnormal parotid excretory duct morphology

[Term]
id: MP:0009531
name: increased parotid gland size
def: "increased size of either of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged parotid gland" EXACT []
synonym: "increased external salivary gland size" EXACT []
synonym: "increased glandula parotidea size" EXACT []
synonym: "increased glandula parotis size" EXACT []
is_a: MP:0003452 ! abnormal parotid gland morphology

[Term]
id: MP:0009532
name: decreased parotid gland size
def: "reduced size of either of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased external salivary gland size" EXACT []
synonym: "decreased glandula parotidea size" EXACT []
synonym: "decreased glandula parotis size" EXACT []
synonym: "reduced external salivary gland size" EXACT []
synonym: "reduced glandula parotidea size" EXACT []
synonym: "reduced glandula parotis size" EXACT []
synonym: "reduced parotid gland size" EXACT []
synonym: "small parotid gland" RELATED []
is_a: MP:0003452 ! abnormal parotid gland morphology

[Term]
id: MP:0009533
name: absent palatine gland
def: "absence of the salivary gland of the hard palate" [ISBN:0-683-40008-8]
synonym: "absent glandulae palatinae" EXACT []
is_a: MP:0000615 ! abnormal palatine gland morphology

[Term]
id: MP:0009534
name: absent anterior lingual gland
def: "absence of the small glands located near the apex of the tongue on either side of the frenulum" [ISBN:0-683-40008-8]
synonym: "absent apical gland" EXACT []
synonym: "absent Bauhin gland" EXACT []
synonym: "absent Blandin gland" EXACT []
synonym: "absent glandula lingualis anterior" EXACT []
synonym: "absent lingual gland" EXACT []
synonym: "absent Nuhn gland" EXACT []
is_a: MP:0009518 ! abnormal anterior lingual gland morphology

[Term]
id: MP:0009535
name: abnormal skin sebaceous gland morphology
def: "any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8]
is_a: MP:0000647 ! abnormal sebaceous gland morphology
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0009536
name: abnormal interstitial cell of Cajal morphology
def: "any structural anomaly in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction" [https://orcid.org/0000-0002-6490-7723, PMID:16460275]
synonym: "abnormal ICC morphology" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology

[Term]
id: MP:0009537
name: interstitial cells of Cajal hyperplasia
def: "increased number of the pacemaker cells of the gastrointestinal tract which mediate inputs from the enteric nervous system to smooth muscle cells and trigger gut contraction" [https://orcid.org/0000-0002-6490-7723, PMID:16460275]
synonym: "ICC hyperplasia" EXACT []
is_a: MP:0009536 ! abnormal interstitial cell of Cajal morphology

[Term]
id: MP:0009538
name: abnormal synapse morphology
def: "any structural anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8, MESH:A08.850]
is_a: MP:0002882 ! abnormal neuron morphology

[Term]
id: MP:0009539
name: abnormal Hassall's corpuscle morphology
def: "any structural anomaly of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8]
synonym: "abnormal Hassal body morphology" EXACT []
synonym: "abnormal Hassall concentric corpuscle morphology" EXACT []
synonym: "abnormal thymic corpuscle morphology" EXACT []
synonym: "abnormal Virchow-Hassall body morphology" EXACT []
is_a: MP:0002375 ! abnormal thymus medulla morphology
is_a: MP:0009544 ! abnormal thymus epithelium morphology

[Term]
id: MP:0009540
name: absent Hassall's corpuscle
def: "absence of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8]
is_a: MP:0009539 ! abnormal Hassall's corpuscle morphology

[Term]
id: MP:0009541
name: increased thymocyte apoptosis
def: "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006413 ! increased T cell apoptosis
is_a: MP:0009258 ! abnormal thymocyte apoptosis

[Term]
id: MP:0009542
name: decreased thymocyte apoptosis
def: "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced thymocyte apoptosis" EXACT []
is_a: MP:0006414 ! decreased T cell apoptosis
is_a: MP:0009258 ! abnormal thymocyte apoptosis

[Term]
id: MP:0009543
name: abnormal thymus corticomedullary boundary morphology
def: "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [https://orcid.org/0000-0003-3691-0324, PMID:17067941]
synonym: "abnormal thymic corticomedullary boundary morphology" EXACT []
synonym: "abnormal thymus CMZ morphology" EXACT []
synonym: "abnormal thymus cortico-medullary boundary" EXACT []
synonym: "abnormal thymus cortico-medullary junction" EXACT []
synonym: "abnormal thymus cortico-medullary zone" EXACT []
synonym: "abnormal thymus corticomedullary zone morphology" EXACT []
is_a: MP:0002367 ! abnormal thymus lobule morphology

[Term]
id: MP:0009544
name: abnormal thymus epithelium morphology
def: "any structural anomaly of the supporting framework of the thymus" [https://orcid.org/0000-0003-3691-0324, PMID:17067941]
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0009545
name: abnormal dermis papillary layer morphology
alt_id: MP:0001250
def: "any structural anomaly of the more superficial, thin layer of the dermis that interdigitates with the epidermis" [ISBN:0-683-40008-8]
synonym: "abnormal corpus papillary morphology" EXACT []
synonym: "abnormal papillary layer morphology" EXACT []
synonym: "abnormal stratum papillare corii morphology" EXACT []
synonym: "abnormal stratum papillare morphology" EXACT []
synonym: "abnormal superficial dermis morphology" EXACT []
is_a: MP:0001243 ! abnormal dermal layer morphology

[Term]
id: MP:0009546
name: absent gastric milk in neonates
def: "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2]
synonym: "absence of milk in stomach" EXACT []
synonym: "absent milk spots" EXACT []
is_a: MP:0001438 ! aphagia

[Term]
id: MP:0009547
name: elliptocytosis
def: "hematologic disorder in which an abnormally large number of erythrocytes are elliptical rather than the typical biconcave, disc shape" [MGI:llw2]
synonym: "cigar cells" EXACT []
synonym: "cigar-shaped erythrocytes" EXACT []
synonym: "oval-shaped erythrocytes" EXACT []
synonym: "ovalocytes" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0009548
name: abnormal platelet aggregation
def: "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
synonym: "abnormal blood platelet aggregation" EXACT []
synonym: "abnormal thrombocyte aggregation" EXACT []
is_a: MP:0006298 ! abnormal platelet activation

[Term]
id: MP:0009549
name: decreased platelet aggregation
def: "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
synonym: "decreased blood platelet aggregation" RELATED []
synonym: "decreased thrombocyte aggregation" EXACT []
synonym: "impaired platelet aggregation" EXACT []
synonym: "reduced platelet aggregation" EXACT []
is_a: MP:0009548 ! abnormal platelet aggregation

[Term]
id: MP:0009550
name: increased urinary bladder carcinoma incidence
def: "greater than the expected number of a malignant neoplasm of the urinary bladder, arising from epithelial cells, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "urinary bladder carcinoma" RELATED []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0010289 ! increased urinary system tumor incidence

[Term]
id: MP:0009551
name: increased urinary bladder transitional cell carcinoma incidence
def: "greater than the expected number of a malignant neoplasm of the transitional epithelial layer of the urinary bladder, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "urinary bladder transitional cell carcinoma" RELATED []
is_a: MP:0009550 ! increased urinary bladder carcinoma incidence

[Term]
id: MP:0009552
name: urinary bladder obstruction
def: "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystis urinaria obstruction" EXACT []
synonym: "urocyst obstruction" EXACT []
synonym: "urocystis obstruction" EXACT []
synonym: "vesica obstruction" EXACT []
synonym: "vesica urinaria obstruction" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology

[Term]
id: MP:0009553
name: fused lips
def: "an anomaly of the fleshy margins of the mouth resulting in the upper and lower lips being joined together into one structure" [MGI:mberry]
synonym: "adhesion of upper and lower lips" EXACT []
synonym: "fusion of upper and lower lips" EXACT []
synonym: "lip fusion" EXACT []
is_a: MP:0003769 ! abnormal lip morphology

[Term]
id: MP:0009554
name: abnormal hair follicle melanin granule shape
def: "the form of pigment polymers in the hair follicle differs compared to controls" [MGI:llw2]
is_a: MP:0005072 ! abnormal hair follicle melanin granule morphology

[Term]
id: MP:0009555
name: abnormal hair follicle melanin granule distribution
def: "anomaly in the spatial arrangement of particles produced by melanocytes that confer color in the hair follicle" [MGI:llw2]
is_a: MP:0005072 ! abnormal hair follicle melanin granule morphology

[Term]
id: MP:0009556
name: abnormal platelet ADP level
def: "anomaly in the amount of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry]
synonym: "abnormal platelet adenosine diphosphate level" EXACT []
is_a: MP:0004721 ! abnormal platelet dense granule morphology

[Term]
id: MP:0009557
name: decreased platelet ADP level
def: "reduced concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry]
synonym: "decreased platelet adenosine diphosphate level" EXACT []
synonym: "reduced platelet ADP level" EXACT []
is_a: MP:0009556 ! abnormal platelet ADP level

[Term]
id: MP:0009558
name: increased platelet ADP level
def: "increased concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry]
synonym: "increased platelet adenosine diphosphate level" EXACT []
is_a: MP:0009556 ! abnormal platelet ADP level

[Term]
id: MP:0009559
name: thymus cortex hyperplasia
def: "increase in the number of normal cells in normal arrangement in the thymus cortex, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperplasia of thymic cortex" EXACT []
synonym: "hyperplastic thymus cortex" EXACT []
synonym: "increased cellularity of thymic cortex" EXACT []
synonym: "increased thymic cortex cellularity" EXACT []
synonym: "thymic cortex hyperplasia" EXACT []
is_a: MP:0013593 ! enlarged thymus cortex

[Term]
id: MP:0009560
name: absent epidermis stratum granulosum
def: "absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8]
synonym: "absent epidermal granular layer" EXACT []
synonym: "absent granular layer" EXACT []
synonym: "absent stratum granulosum" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009561
name: superior cervical ganglion degeneration
def: "retrogressive pathological change or loss of the largest group of paravertebral ganglia of the sympathetic trunk which normally lies at the base of the skull and innervates the head and neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "degeneration of ganglion cervicale superius" EXACT []
is_a: MP:0001011 ! abnormal superior cervical ganglion morphology

[Term]
id: MP:0009562
name: abnormal odor adaptation
def: "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal odorant-dependent adaptation" EXACT []
synonym: "abnormal odour adaptation" EXACT []
synonym: "abnormal odourant-dependent adaptation" EXACT []
synonym: "impaired odor adaptation" EXACT []
synonym: "impaired odour adaptation" EXACT []
is_a: MP:0001984 ! abnormal olfaction

[Term]
id: MP:0009563
name: dyskeratosis
def: "premature keratinization in individual epithelial cells that have not reached the keratinizing surface layer; dyskeratotic cells generally become rounded and they may break away from adjacent cells and fall off" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0002060 ! abnormal skin morphology

[Term]
id: MP:0009564
name: abnormal meiotic configurations
def: "uncharacteristic chromosome arrangement produced by anomalous chromosome pairing and chiasma formation from prophase to metaphase of meiosis I due to abnormal chromosome structure and necessary to produce functional gametes" [MGI:llw2]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009565
name: multivalent meiotic configurations
def: "any association of more than two completely or partially homologous chromosomes whose homologous regions are held together by pairing and chiasma formation from prophase to metaphase of meiosis I" [MGI:llw2]
is_a: MP:0009564 ! abnormal meiotic configurations

[Term]
id: MP:0009566
name: meiotic nondisjunction
def: "failure of homologous chromosomes to separate to the cell poles at anaphase" [MGI:llw2]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009567
name: mitotic nondisjunction
def: "failure of sister-chromatids to separate to the cell poles at anaphase" [MGI:llw2]
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0009568
name: abnormal red blood cell deformability
def: "a measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress" [MGI:llw2]
is_a: MP:0002447 ! abnormal erythrocyte morphology

[Term]
id: MP:0009569
name: abnormal left lung morphology
def: "any structural anomaly of the organ of respiration located on the left side of the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0009570
name: abnormal right lung morphology
def: "any structural anomaly of the part of the organ of respiration located on the right side of the body and consists of the caudal, cranial, middle and accessory lobes" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001175 ! abnormal lung morphology

[Term]
id: MP:0009571
name: abnormal right lung accessory lobe morphology
def: "any structural anomaly of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax" [ISBN:0486631850, PMID:2050021]
comment: The accessory lobe is not seen in all mammalian species. It is present in rodents and is absent in human.
synonym: "abnormal right lung cardiac lobe morphology" EXACT []
synonym: "abnormal right lung infracardiac lobe morphology" EXACT []
synonym: "abnormal right lung median lobe morphology" EXACT []
synonym: "abnormal right lung postcaval lobe morphology" EXACT []
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010975 ! abnormal lung lobe morphology

[Term]
id: MP:0009572
name: abnormal right lung cranial lobe morphology
def: "any structural anomaly of the upper lobe of the right lung" [https://doi.org/10.1016/B978-0-323-79547-0.00010-2]
synonym: "abnormal right lung anterior lobe morphology" EXACT []
synonym: "abnormal right lung superior lobe morphology" EXACT []
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010975 ! abnormal lung lobe morphology

[Term]
id: MP:0009573
name: abnormal right lung middle lobe morphology
def: "any structural anomaly of the medial lobe of the right lung" [https://doi.org/10.1016/B978-0-323-79547-0.00010-2]
synonym: "abnormal right lung medial lobe morphology" EXACT []
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010975 ! abnormal lung lobe morphology

[Term]
id: MP:0009574
name: abnormal right lung caudal lobe morphology
def: "any structural anomaly of the lower lobe of the right lung" [https://doi.org/10.1016/B978-0-323-79547-0.00010-2]
synonym: "abnormal right lung inferior lobe morphology" EXACT []
synonym: "abnormal right lung posterior lobe morphology" EXACT []
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010975 ! abnormal lung lobe morphology

[Term]
id: MP:0009575
name: abnormal pubic symphysis morphology
def: "any structural anomaly of the firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal symphysis pubica" RELATED []
synonym: "abnormal symphysis pubis" RELATED []
is_a: MP:0004506 ! abnormal pubis morphology
is_a: MP:0030818 ! abnormal girdle joint morphology
is_a: MP:0030877 ! abnormal symphysis morphology

[Term]
id: MP:0009576
name: oral atresia
def: "congenital blockage, fusion, or absence of the normal opening of the oral cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "atresia oris" EXACT []
synonym: "congenital atresia of the mouth" EXACT []
synonym: "mouth atresia" EXACT []
synonym: "oral fusion" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology

[Term]
id: MP:0009577
name: abnormal developmental vascular remodeling
def: "any anomaly in the process by which existing vessels are reorganized during development" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC_Prenatal
is_a: MP:0000260 ! abnormal angiogenesis

[Term]
id: MP:0009578
name: otocephaly
def: "a structural anomaly of the head consisting of absence or malformation of the lower jaw and the ears united or closely approaching below the face" [ISBN:0-683-40008-8]
is_a: MP:0011495 ! abnormal head shape

[Term]
id: MP:0009579
name: acephaly
def: "congenital absence of the head" [ISBN:0-683-40008-8]
synonym: "absence of the head" EXACT []
synonym: "absent head" EXACT []
synonym: "acephalia" EXACT []
synonym: "acephalism" EXACT []
is_a: MP:0000432 ! abnormal head morphology

[Term]
id: MP:0009580
name: increased keratinocyte apoptosis
def: "increase in the number of keratinocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001224 ! abnormal keratinocyte apoptosis
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0009581
name: decreased keratinocyte apoptosis
def: "reduction in the number of keratinocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced keratinocyte apoptosis" EXACT []
is_a: MP:0001224 ! abnormal keratinocyte apoptosis
is_a: MP:0006043 ! decreased apoptosis

[Term]
id: MP:0009582
name: abnormal keratinocyte proliferation
def: "anomaly in the ability of keratinocytes to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0003453 ! abnormal keratinocyte physiology

[Term]
id: MP:0009583
name: increased keratinocyte proliferation
def: "increase in the expansion rate of keratinocytes by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0009582 ! abnormal keratinocyte proliferation

[Term]
id: MP:0009584
name: decreased keratinocyte proliferation
def: "reduction in the expansion rate of keratinocytes by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced keratinocyte proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009582 ! abnormal keratinocyte proliferation

[Term]
id: MP:0009585
name: obsolete ectopic bone formation
def: "OBSOLETE. formation of bone at an abnormal site or in an atypical tissue, usually outside its normal location" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic bone development" EXACT []
synonym: "heterotopic bone formation" EXACT []
is_obsolete: true
replaced_by: MP:0014167

[Term]
id: MP:0009586
name: increased platelet aggregation
def: "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased blood platelet aggregation" EXACT []
synonym: "increased thrombocyte aggregation" EXACT []
is_a: MP:0009548 ! abnormal platelet aggregation

[Term]
id: MP:0009587
name: abnormal plasma membrane sphingolipid content
def: "altered amounts of the phospholipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2]
is_a: MP:0003950 ! abnormal plasma membrane morphology

[Term]
id: MP:0009588
name: increased plasma membrane sphingolipid content
def: "abnormal accumulation of the phospolipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2]
is_a: MP:0009587 ! abnormal plasma membrane sphingolipid content

[Term]
id: MP:0009589
name: sphingomyelinosis
def: "the abnormal accumulation of sphingomyelin in the plasma membrane of cells of the nervous tissue, liver and spleen, usually due to sphingomyelinase deficiency" [MGI:llw2]
synonym: "sphingolipidosis" EXACT []
synonym: "sphingolipodystrophy" EXACT []
synonym: "sphingomyelin lipidosis" EXACT []
is_a: MP:0009587 ! abnormal plasma membrane sphingolipid content
is_a: MP:0009823 ! abnormal sphingomyelin level

[Term]
id: MP:0009590
name: increased gonad tumor incidence
def: "greater than the expected number of an abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "gonad tumor" RELATED []
synonym: "gonad tumour" RELATED []
synonym: "increased gonad tumour incidence" EXACT []
is_a: MP:0010287 ! increased reproductive system tumor incidence

[Term]
id: MP:0009591
name: increased liver adenocarcinoma incidence
def: "greater than the expected number of a malignant neoplasm of epithelial cells in the liver, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "hepatic adenocarcinoma" RELATED []
synonym: "liver adenocarcinoma" RELATED []
is_a: MP:0008019 ! increased liver tumor incidence
is_a: MP:0009308 ! increased adenocarcinoma incidence

[Term]
id: MP:0009592
name: increased Leydig cell tumor incidence
def: "greater than the expected number of rare testicular tumors of the male gonadal interstitium, occurring in a specific population in a given time period; Leydig cell tumors are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased Leydig cell tumour incidence" EXACT []
synonym: "interstitial cell tumor of testis" RELATED []
synonym: "interstitial cell tumour of testis" RELATED []
synonym: "Leydig cell tumor" RELATED []
synonym: "Leydig cell tumour" RELATED []
is_a: MP:0006262 ! increased testis tumor incidence

[Term]
id: MP:0009593
name: absent chorion
def: "absence of the outermost extraembryonic membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent membrana serosa" EXACT []
is_a: MP:0002836 ! abnormal chorion morphology

[Term]
id: MP:0009594
name: abnormal corneocyte envelope morphology
def: "any structural anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cornified envelope morphology" EXACT []
synonym: "abnormal subplasmalemmal dense zone" EXACT []
is_a: MP:0030605 ! abnormal corneocyte morphology

[Term]
id: MP:0009595
name: enlarged corneocyte envelope
def: "increased size of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged cornified envelope" EXACT []
synonym: "enlarged subplasmalemmal dense zone" EXACT []
synonym: "increased corneocyte envelope size" EXACT []
is_a: MP:0009594 ! abnormal corneocyte envelope morphology

[Term]
id: MP:0009596
name: abnormal stratum corneum lipid matrix formation
def: "altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intercorneocyte lamellar lipids" EXACT []
synonym: "abnormal intercorneocyte lipid lamellae" EXACT []
synonym: "abnormal stratum corneum extracellular lipid matrix" EXACT []
synonym: "defective epidermal lipid matrix composition" EXACT []
synonym: "epidermal lipid matrix defects" EXACT []
is_a: MP:0001240 ! abnormal epidermis stratum corneum morphology

[Term]
id: MP:0009597
name: impaired stratum corneum desquamation
def: "dysregulated shedding of the outermost layer of corneocytes, affecting the integrity and thickness of the stratum corneum; may result in xerotic and ichthyotic conditions" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal corneocyte desquamation" EXACT []
synonym: "impaired corneocyte shedding" EXACT []
is_a: MP:0001240 ! abnormal epidermis stratum corneum morphology

[Term]
id: MP:0009598
name: thin epidermis stratum granulosum
def: "decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8]
synonym: "thin epidermal granular layer" EXACT []
synonym: "thin granular layer" EXACT []
synonym: "thin stratum granulosum" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009599
name: thick epidermis stratum granulosum
def: "increased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8]
synonym: "thick epidermal granular layer" EXACT []
synonym: "thick granular layer" EXACT []
synonym: "thick stratum granulosum" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009600
name: hypergranulosis
def: "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8]
is_a: MP:0009599 ! thick epidermis stratum granulosum

[Term]
id: MP:0009601
name: epidermis stratum granulosum hyperplasia
def: "increase in the number of normal cells in normal arrangement in the epidermal stratum granulosum, typically resulting in increased size" [ISBN:0-683-40008-8]
synonym: "epidermal granular layer hyperplasia" EXACT []
synonym: "granular layer hyperplasia" EXACT []
synonym: "hyperplastic epidermal stratum granulosum" EXACT []
synonym: "stratum granulosum hyperplasia" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009602
name: abnormal keratohyalin granule morphology
def: "any structural anomaly of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal keratohyaline granule morphology" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009603
name: absent keratohyalin granules
def: "absence of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent keratohyaline granules" EXACT []
is_a: MP:0009605 ! decreased keratohyalin granule number

[Term]
id: MP:0009604
name: increased keratohyalin granule number
def: "increased number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased keratohyaline granule number" EXACT []
is_a: MP:0009602 ! abnormal keratohyalin granule morphology

[Term]
id: MP:0009605
name: decreased keratohyalin granule number
def: "reduced number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased keratohyaline granule number" EXACT []
synonym: "reduced keratohyalin granule number" EXACT []
synonym: "reduced keratohyaline granule number" EXACT []
is_a: MP:0009602 ! abnormal keratohyalin granule morphology

[Term]
id: MP:0009606
name: increased keratohyalin granule size
def: "increased size of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased keratohyaline granule size" EXACT []
is_a: MP:0009602 ! abnormal keratohyalin granule morphology

[Term]
id: MP:0009607
name: decreased keratohyalin granule size
def: "reduced size of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased keratohyaline granule size" EXACT []
synonym: "reduced keratohyalin granule size" EXACT []
synonym: "reduced keratohyaline granule size" EXACT []
is_a: MP:0009602 ! abnormal keratohyalin granule morphology

[Term]
id: MP:0009608
name: abnormal epidermal lamellar body morphology
def: "any structural anomaly of a membrane-bounded organelle present in the epidermis, specialized for the storage and secretion of various substances (such as glycoproteins and acid phosphates), and which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
comment: The name includes epidermal to distinguish it from lung alveolar cell lamellar bodies.
synonym: "abnormal keratinosome morphology" EXACT []
synonym: "abnormal lamellar body morphology" EXACT []
synonym: "abnormal lamellar granule morphology" EXACT []
synonym: "abnormal membrane-coating granule morphology" RELATED []
synonym: "abnormal Odland body morphology" EXACT []
synonym: "abnormal skin lamellar body morphology" EXACT []
is_a: MP:0001239 ! abnormal epidermis stratum granulosum morphology

[Term]
id: MP:0009609
name: absent basioccipital bone
def: "absence of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8]
is_a: MP:0000079 ! abnormal basioccipital bone morphology

[Term]
id: MP:0009610
name: abnormal epidermis stratum lucidum morphology
alt_id: MP:0005082
def: "any structural anomaly of the layer of lightly staining corneocytes foud between the stratum granulosum and stratum corneum layers; found primarily in the thick epidermis of the palmar and plantar skin and is composed of three to five layers of dead, flattened keratinocytes" [ISBN:0-683-40008-8]
synonym: "abnormal clear layer morphology" EXACT []
synonym: "abnormal stratum lucidum" EXACT []
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0009611
name: epidermis stratum spinosum hyperplasia
def: "increase in the number of normal cells in normal arrangement in the epidermis stratum spinosum, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperplastic epidermal stratum spinosum" EXACT []
synonym: "prickle cell layer hyperplasia" EXACT []
synonym: "spinous layer hyperplasia" EXACT []
synonym: "stratum spinosum hyperplasia" RELATED []
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0009612
name: thick epidermis suprabasal layer
def: "increased thickness of the suprabasal layer of the epidermis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001233 ! abnormal epidermis suprabasal layer morphology

[Term]
id: MP:0009613
name: thin epidermis suprabasal layer
def: "decreased thickness of the suprabasal layer of the epidermis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001233 ! abnormal epidermis suprabasal layer morphology

[Term]
id: MP:0009614
name: absent epidermis stratum spinosum
def: "absence of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [ISBN:0-683-40008-8]
synonym: "absent prickle cell layer" EXACT []
synonym: "absent spinous layer" EXACT []
synonym: "absent stratum spinosum" EXACT []
is_a: MP:0001236 ! abnormal epidermis stratum spinosum morphology

[Term]
id: MP:0009615
name: abnormal zinc homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005636 ! abnormal mineral homeostasis

[Term]
id: MP:0009616
name: abnormal brain zinc level
def: "any anomaly in the amount of zinc present in mammalian brain tissue, where 5-15 percent of total zinc is concentrated in synaptic vesicles in a subset of glutamatergic neurons; histochemically reactive zinc is present in many regions of the central nervous system and is especially abundant in the hippocampus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0020893 ! abnormal zinc level

[Term]
id: MP:0009617
name: decreased brain zinc level
def: "reduction in the amount of zinc present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain zinc level" EXACT []
is_a: MP:0009616 ! abnormal brain zinc level
is_a: MP:0014550 ! decreased zinc level

[Term]
id: MP:0009618
name: increased brain zinc level
def: "increase in the amount of zinc present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009616 ! abnormal brain zinc level
is_a: MP:0014549 ! increased zinc level

[Term]
id: MP:0009619
name: abnormal optokinetic reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal OKR" EXACT []
is_a: MP:0001961 ! abnormal reflex

[Term]
id: MP:0009620
name: abnormal primary vitreous morphology
def: "any structural anomaly in the fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0002699 ! abnormal vitreous body morphology

[Term]
id: MP:0009621
name: primary vitreous hyperplasia
def: "increase in the number of normal cells in normal arrangement in the primary vitreous, typically resulting in increased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyperplastic primary vitreous" EXACT []
is_a: MP:0009620 ! abnormal primary vitreous morphology

[Term]
id: MP:0009622
name: absent inguinal lymph nodes
def: "absence of the lymph nodes normally located in the groin area" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002353 ! abnormal inguinal lymph node morphology

[Term]
id: MP:0009623
name: enlarged inguinal lymph nodes
def: "increased size of the lymph nodes located in the groin area" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased inguinal lymph node size" EXACT []
is_a: MP:0002353 ! abnormal inguinal lymph node morphology

[Term]
id: MP:0009624
name: small inguinal lymph nodes
def: "reduced size of the lymph nodes located in the groin area" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased inguinal lymph node size" EXACT []
synonym: "reduced inguinal lymph nodes" EXACT []
is_a: MP:0002353 ! abnormal inguinal lymph node morphology

[Term]
id: MP:0009625
name: abnormal abdominal lymph node morphology
def: "any structural anomaly of the visceral glands that are located in the abdomen" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002339 ! abnormal lymph node morphology

[Term]
id: MP:0009626
name: abnormal celiac lymph node morphology
def: "any structural anomaly of the visceral glands that are associated with the branches of the celiac artery, including the gastric, hepatic, and pancreaticolienal (splenic) lymph nodes" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal coeliac lymph node morphology" EXACT []
is_a: MP:0009625 ! abnormal abdominal lymph node morphology

[Term]
id: MP:0009627
name: abnormal submandibular lymph node morphology
def: "any structural anomaly of the lymph nodes located below the mandible in the submandibular triangle that collect lymph from the cheeks, the lateral aspects of the nose, upper lip, lateral parts of the lower lip, gums and the anterior tongue; they also receive lymph from the submental and facial lymph nodes" [https://teachmeanatomy.info/neck/vessels/lymphatics/]
is_a: MP:0008463 ! abnormal peripheral lymph node morphology

[Term]
id: MP:0009628
name: absent brachial lymph nodes
def: "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "absent humeral axillary lymph nodes" EXACT []
is_a: MP:0005231 ! abnormal brachial lymph node morphology

[Term]
id: MP:0009629
name: small brachial lymph nodes
def: "reduced size of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "reduced brachial lymph node size" EXACT []
synonym: "reduced humeral axillary lymph node size" EXACT []
synonym: "small humeral axillary lymph nodes" EXACT []
is_a: MP:0002217 ! small lymph nodes
is_a: MP:0005231 ! abnormal brachial lymph node morphology

[Term]
id: MP:0009630
name: absent axillary lymph nodes
def: "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0002340 ! abnormal axillary lymph node morphology

[Term]
id: MP:0009631
name: enlarged axillary lymph nodes
def: "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "increased axillary lymph node size" EXACT []
is_a: MP:0002340 ! abnormal axillary lymph node morphology

[Term]
id: MP:0009632
name: small axillary lymph nodes
def: "reduced size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "reduced axillary lymph node size" EXACT []
is_a: MP:0002217 ! small lymph nodes
is_a: MP:0002340 ! abnormal axillary lymph node morphology

[Term]
id: MP:0009633
name: absent cervical lymph nodes
def: "absence of the lymph nodes normally found near the neck and shoulders" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002351 ! abnormal cervical lymph node morphology

[Term]
id: MP:0009634
name: absent popliteal lymph nodes
def: "absence of the lymph nodes which drain the legs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002352 ! abnormal popliteal lymph node morphology

[Term]
id: MP:0009635
name: enlarged popliteal lymph nodes
def: "increased size of the lymph nodes which drain the legs" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased popliteal lymph node size" EXACT []
is_a: MP:0002352 ! abnormal popliteal lymph node morphology

[Term]
id: MP:0009636
name: small popliteal lymph nodes
def: "reduced size of the lymph nodes which drain the legs" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased popliteal lymph node size" EXACT []
synonym: "reduced popliteal lymph node size" EXACT []
is_a: MP:0002352 ! abnormal popliteal lymph node morphology

[Term]
id: MP:0009637
name: abnormal pretectal region morphology
def: "any structural anomaly of a narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light reflex" [ISBN:0-683-40008-8]
synonym: "abnormal pretectal area morphology" EXACT []
synonym: "abnormal pretectum morphology" EXACT []
synonym: "abnormal PRT morphology" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology

[Term]
id: MP:0009638
name: abnormal pretectal nuclei morphology
def: "any structural anomaly of the groups of neurons located between the thalamus and midbrain that receive binocular sensory input from retinal ganglion cells of the eyes and are responsible for maintaining the pupillary light reflex" [MGI:llw2]
is_a: MP:0009637 ! abnormal pretectal region morphology

[Term]
id: MP:0009639
name: abnormal olivary pretectal nucleus morphology
def: "any structural anomaly of one of several pretectal nuclei with direct input from the eye and the only one containing neurons whose rate of firing is linearly related to the intensity of light falling on the retina" [MGI:llw2]
is_a: MP:0009638 ! abnormal pretectal nuclei morphology

[Term]
id: MP:0009640
name: abnormal renal tubule epithelium morphology
def: "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal kidney tubule epithelium morphology" EXACT []
xref: MA:0001681
is_a: MP:0002703 ! abnormal renal tubule morphology
is_a: MP:0004967 ! abnormal kidney epithelium morphology

[Term]
id: MP:0009641
name: kidney degeneration
def: "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "renal degeneration" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology

[Term]
id: MP:0009642
name: abnormal blood homeostasis
alt_id: MP:0000179
alt_id: MP:0001546
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal blood chemistry" EXACT []
synonym: "blood chemistry abnormalities" EXACT []
is_a: MP:0001764 ! abnormal homeostasis

[Term]
id: MP:0009643
name: abnormal urine homeostasis
alt_id: MP:0001757
alt_id: MP:0005427
alt_id: MP:0005555
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of the various chemical or protein components of the urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal kidney excretion" BROAD []
synonym: "abnormal renal excretion" BROAD []
synonym: "abnormal urinalysis" EXACT []
synonym: "abnormal urine chemistry" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
is_a: MP:0005502 ! abnormal renal/urinary system physiology

[Term]
id: MP:0009644
name: uremia
def: "an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8]
synonym: "azotaemia" EXACT []
synonym: "azotemia" EXACT []
synonym: "uraemia" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0009645
name: crystalluria
def: "excretion of crystalline material in the urine" [ISBN:0-683-40008-8]
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0009646
name: urinary bladder inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [https://orcid.org/0000-0003-3691-0324]
synonym: "cystitis" EXACT []
is_a: MP:0010386 ! abnormal urinary bladder physiology
is_a: MP:0011762 ! renal/urinary system inflammation

[Term]
id: MP:0009647
name: decreased fertilization frequency
def: "the number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2]
is_a: MP:0000242 ! impaired fertilization

[Term]
id: MP:0009648
name: abnormal superovulation
def: "altered ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2]
is_a: MP:0001928 ! abnormal ovulation

[Term]
id: MP:0009649
name: delayed embryo implantation
def: "any lag in the normal time course necessary for the attachment of the blastocyst to the endometrium" [ISBN:0198542771, MGI:llw2, PMID:10882512]
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009650
name: dormant blastocysts
def: "blastocysts sometimes larger than normal in size, showing no development or mitotic activity as a result of delayed implantation" [ISBN:0198542771, MGI:llw2]
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009651
name: abnormal eyelid development
def: "aberrant formation of the skin folds covering the front of the eyeball" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal blephara development" EXACT []
synonym: "abnormal blepharon development" EXACT []
synonym: "abnormal eye lid development" EXACT []
synonym: "abnormal palpebra development" EXACT []
synonym: "abnormal palpebrae development" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0009652
name: abnormal palatal rugae morphology
def: "any structural anomaly in the series of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species; rugae are present on each side of the median palatal raphe and behind the incisive papillae, but their number and arrangement are species specific; together with the teeth and the tongue, rugae take part in mastication by helping to sense, hold and mash the food; rugae harbor various types of intraepithelial sensory structures (such as Merckel cells, corpuscular endings and free nerve endings), and play a sensory role when the food is pressed by the tongue against the hard palate" [https://orcid.org/0000-0002-6490-7723, PMID:19087265]
synonym: "abnormal impressiones rugales morphology" EXACT []
synonym: "abnormal palatal ridge morphology" EXACT []
synonym: "abnormal palatine fold morphology" EXACT []
synonym: "abnormal palatine rugae morphology" EXACT []
synonym: "abnormal plica palatina transversa morphology" EXACT []
synonym: "abnormal plica palatinae transversae morphology" EXACT []
synonym: "abnormal plicae palatinae transversae morphology" EXACT []
synonym: "abnormal ruga of palate morphology" EXACT []
synonym: "abnormal ruga palatina morphology" EXACT []
synonym: "abnormal rugae of palate morphology" EXACT []
synonym: "abnormal rugae palatinae morphology" EXACT []
synonym: "abnormal transverse palatine fold morphology" EXACT []
synonym: "abnormal transverse palatine folds set" EXACT []
synonym: "abnormal transverse palatine ridge morphology" EXACT []
is_a: MP:0003756 ! abnormal hard palate morphology

[Term]
id: MP:0009653
name: abnormal palate development
def: "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal paletogenesis" EXACT []
is_a: MP:0003755 ! abnormal palate morphology
is_a: MP:0003935 ! abnormal craniofacial development

[Term]
id: MP:0009654
name: abnormal primary palate development
def: "any anomaly in the formation of the part of the shelf separating the oral and nasal cavities that is formed during early embryonic development from the medial nasal processes which derive from the frontonasal process; these merge with each other and with the bilateral maxillary processes to form the upper lip and the primary palate" [MGI:llw2, PMID:16942766]
synonym: "abnormal primary palate primordia" RELATED []
synonym: "abnormal primitive palate development" EXACT []
is_a: MP:0009653 ! abnormal palate development

[Term]
id: MP:0009655
name: abnormal secondary palate development
def: "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2, PMID:16942766]
is_a: MP:0009653 ! abnormal palate development

[Term]
id: MP:0009656
name: delayed chorioallantoic fusion
def: "late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [https://orcid.org/0000-0002-6490-7723]
synonym: "retarded chorioallantoic fusion" EXACT []
is_a: MP:0002824 ! abnormal chorioallantoic fusion

[Term]
id: MP:0009657
name: failure of chorioallantoic fusion
def: "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [https://orcid.org/0000-0002-6490-7723]
synonym: "chorioallantoic fusion failure" EXACT []
is_a: MP:0002824 ! abnormal chorioallantoic fusion

[Term]
id: MP:0009658
name: increased placenta apoptosis
def: "increase in the number of cells of the placenta undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased placental apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0010038 ! abnormal placenta physiology

[Term]
id: MP:0009659
name: striated fur
def: "hair or fur characterized by transverse, usually parallel, markings due to an anomaly in hair color, texture, or growth" [MGI:llw2]
synonym: "striped coat" EXACT []
synonym: "striped fur" EXACT []
is_a: MP:0001510 ! abnormal coat appearance

[Term]
id: MP:0009660
name: abnormal induced retina neovascularization
def: "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal induced retinal neovascularization" EXACT []
is_a: MP:0008852 ! retina neovascularization

[Term]
id: MP:0009661
name: abnormal pregnancy
def: "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771, MGI:llw2]
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0009662
name: abnormal uterine receptivity
def: "any alteration in the time sensitive process of uterine differentiation that occurs in response to implantation competent blastocysts and precedes and is necessary for embryo implantation" [PMID:10882512]
is_a: MP:0004014 ! abnormal uterine environment

[Term]
id: MP:0009663
name: abnormal uterine-embryonic axis
def: "any anomaly in the process whereby the implantation chamber orients in the uterus in response to decidual growth to insure correct alignment of the embryo to the uterus" [MGI:llw2, PMID:10882512]
is_a: MP:0001727 ! abnormal embryo implantation
is_a: MP:0009669 ! abnormal postimplantation uterine environment

[Term]
id: MP:0009664
name: abnormal luminal closure
def: "an anomaly in the degree to which (for each species) the uterine epithelium closes over and makes contact with, and secures an implanting blastocyst" [MGI:llw2, PMID:10882512]
is_a: MP:0001727 ! abnormal embryo implantation
is_a: MP:0004014 ! abnormal uterine environment

[Term]
id: MP:0009665
name: abnormal embryo apposition
def: "any anomaly that prevents the initial positioning of the blastocyst trophoblast and uterine luminal epithelium causing the blastocyst to fail to orientate correctly along the uterine wall" [MGI:llw2, PMID:10882512]
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009666
name: abnormal embryo attachment
def: "any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2, PMID:10882512]
synonym: "abnormal embryo adhesion" EXACT []
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009667
name: abnormal embryo invasion
def: "any anomaly in the process that enables the embryo to establish connection to the uterine luminal epithelium" [MGI:llw2, PMID:10882512]
synonym: "abnormal embryo penetration" EXACT []
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009668
name: ectopic pregnancy
def: "a fertilized egg attaches and begins development in a location other than in the inner lining of the uterus, most commonly in the Fallopian tube" [MGI:llw2, PMID:10882512]
is_a: MP:0009661 ! abnormal pregnancy

[Term]
id: MP:0009669
name: abnormal postimplantation uterine environment
def: "failure of the uterus to undergo the changes necessary to support pregnancy following implantation of the embryo" [MGI:llw2, PMID:10882512]
is_a: MP:0004014 ! abnormal uterine environment
is_a: MP:0009671 ! abnormal uterus physiology

[Term]
id: MP:0009670
name: abnormal uterine angiogenesis
def: "any anomaly in vascular permeability and blood vessel development that normally occurs in the uterus to support embryonic growth during pregnancy" [MGI:llw2, PMID:10882512]
is_a: MP:0009669 ! abnormal postimplantation uterine environment

[Term]
id: MP:0009671
name: abnormal uterus physiology
def: "any functional anomaly of the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal uterine physiology" EXACT []
is_a: MP:0003699 ! abnormal female reproductive system physiology

[Term]
id: MP:0009672
name: abnormal birth weight
def: "anomaly in average weight at birth compared to controls" [RGD:cur]
is_a: MP:0009701 ! abnormal birth body size

[Term]
id: MP:0009673
name: increased birth weight
def: "increase in average weight at birth compared to controls" [RGD:cur]
is_a: MP:0009672 ! abnormal birth weight
is_a: MP:0009702 ! increased birth body size

[Term]
id: MP:0009674
name: decreased birth weight
def: "reduction in average weight at birth compared to controls" [RGD:cur]
synonym: "reduced birth weight" EXACT []
is_a: MP:0009672 ! abnormal birth weight
is_a: MP:0009703 ! decreased birth body size

[Term]
id: MP:0009675
name: orthokeratosis
def: "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "orthokeratotic hyperkeratosis" EXACT []
is_a: MP:0001242 ! hyperkeratosis

[Term]
id: MP:0009676
name: abnormal hemostasis
def: "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [https://orcid.org/0000-0002-6490-7723, MESH:G09.188.124.560]
synonym: "abnormal haemostasia" EXACT []
synonym: "abnormal haemostasis" EXACT []
synonym: "abnormal hemostasia" EXACT []
synonym: "impaired haemostasis" EXACT []
synonym: "impaired hemostasis" EXACT []
xref: GO:0007599
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0009677
name: abnormal spinal cord dorsal column morphology
def: "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN-10:0940780577, ISBN:0-683-40008-8]
comment: Note that the synonym posterior column may refer to either the grey matter dorsal horn or the white matter dorsal column in the spinal cord.
synonym: "abnormal dorsal funiculus morphology" EXACT []
synonym: "abnormal posterior funiculus morphology" EXACT []
synonym: "abnormal spinal cord posterior column morphology" EXACT []
xref: MA:0002749
is_a: MP:0008027 ! abnormal spinal cord white matter morphology

[Term]
id: MP:0009678
name: abnormal spinal cord lateral column morphology
def: "any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots" [ISBN:0-683-40008-8]
synonym: "abnormal anteriolateral column morphology" EXACT []
synonym: "abnormal lateral funiculus morphology" EXACT []
xref: MA:0002750
is_a: MP:0008027 ! abnormal spinal cord white matter morphology

[Term]
id: MP:0009679
name: abnormal spinal cord ventral column morphology
def: "any structural anomaly of the area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure" [ISBN:0-683-40008-8]
comment: Note that the synonym anterior column may refer to either the grey matter ventral horn or the white matter ventral column in the spinal cord.
synonym: "abnormal anterior funiculus morphology" RELATED []
synonym: "abnormal ventral funiculus morphology" RELATED []
xref: MA:0002751
is_a: MP:0008027 ! abnormal spinal cord white matter morphology

[Term]
id: MP:0009680
name: abnormal medulla oblongata anterior median fissure morphology
def: "any structural anomaly of the longitudinal groove in the midline of the anterior aspect of the medulla oblongata" [ISBN:0-683-40008-8]
synonym: "abnormal anteriomedian groove morphology" EXACT []
is_a: MP:0000846 ! abnormal medulla oblongata morphology

[Term]
id: MP:0009681
name: abnormal pyramidal decussation morphology
def: "any structural anomaly of the bundles of pyramidal fibers that intercross obliquely over the midline at the lower border region of the medulla oblongata" [ISBN:0-683-40008-8]
synonym: "abnormal decussation of pyramids" EXACT []
synonym: "abnormal motor decussation morphology" EXACT []
is_a: MP:0009680 ! abnormal medulla oblongata anterior median fissure morphology

[Term]
id: MP:0009682
name: abnormal anterior corticospinal tract morphology
def: "any structural anomaly of the small bundle of corticospinal motor fibers that do not cross the midline at the pyramidal decussation and descend into the anterior funiculus of the spinal cord; the anterior corticospinal tract controls central axial and girdle muscles" [ISBN:0-683-40008-8]
synonym: "abnormal anterior cerebrospinal fasciculus morphology" EXACT []
synonym: "abnormal anterior pyramidal fasciculus morphology" EXACT []
synonym: "abnormal anterior pyramidal tract morphology" EXACT []
synonym: "abnormal direct pyramidal tract morphology" EXACT []
synonym: "abnormal medial corticospinal tract morphology" EXACT []
synonym: "abnormal Turck bundle morphology" EXACT []
synonym: "abnormal Turck column morphology" EXACT []
synonym: "abnormal ventral corticospinal tract morphology" EXACT []
is_a: MP:0000778 ! abnormal nervous system tract morphology

[Term]
id: MP:0009683
name: abnormal lateral corticospinal tract morphology
def: "any structural anomaly of the large bundle of corticospinal motor fibers that cross the midline at the pyramidal decussation and descend in the dorsal half of the lateral funiculus; the lateral corticospinal tract controls movement of contralateral limbs" [ISBN:0-683-40008-8]
synonym: "abnormal crossed pyramidal tract morphology" EXACT []
synonym: "abnormal lateral cerebrospinal fasciculus morphology" EXACT []
synonym: "abnormal lateral pyramidal tract morphology" EXACT []
is_a: MP:0000778 ! abnormal nervous system tract morphology

[Term]
id: MP:0009684
name: abnormal spinal cord lateral motor column morphology
def: "any structural anomaly of the subclasses of motor neurons which innervate muscles in the limb; motor neurons in the lateral motor column are further organized into pools, each of which innervates a specific muscle in the limb" [PMID:8895454]
synonym: "abnormal LMC morphology" EXACT []
xref: MA:0001129
is_a: MP:0009685 ! abnormal spinal cord motor column morphology

[Term]
id: MP:0009685
name: abnormal spinal cord motor column morphology
def: "any structural anomaly of the subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target" [PMID:8895454]
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0009686
name: abnormal spinal cord medial motor column morphology
def: "any structural anomaly of the subclasses of motor neurons which project their axons to axial muscles that lie close to the vertebral column; motor neurons in the lateral subdivision of the MMC project their axons to body wall muscles" [PMID:8895454]
synonym: "abnormal MMC morphology" EXACT []
is_a: MP:0009685 ! abnormal spinal cord motor column morphology

[Term]
id: MP:0009687
name: empty decidua capsularis
def: "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771, MGI:llw2]
synonym: "empty decidua" EXACT []
is_a: MP:0001727 ! abnormal embryo implantation

[Term]
id: MP:0009688
name: abnormal spinal cord central canal morphology
def: "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8]
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0009689
name: abnormal neural tube ventricular layer morphology
def: "any structural anomaly of the layer of undifferentiated, proliferating cells that line the neural tube lumen" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neural tube ependymal zone morphology" EXACT []
synonym: "abnormal neural tube ventricular zone morphology" RELATED []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0009690
name: abnormal neural tube mantle layer morphology
def: "any structural anomaly of the layer of glia and differentiating neurons that will form the gray matter of the spinal cord; this lies between the ventricular and marginal layers and includes the basal and alar plates" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neural tube intermediate zone morphology" EXACT []
synonym: "abnormal neural tube mantle zone morphology" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0009691
name: abnormal neural tube marginal layer morphology
def: "any structural anomaly of the outermost layer of the neural tube that contains nerve fibers and will form the white matter" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neural tube marginal zone morphology" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0009692
name: abnormal spinal cord alar plate morphology
def: "any structural anomaly of the region of the mantle layer of the neural tube that lies dorsal to the sulcus limitans and contains primarily sensory neurons and interneurons involved in communication of sensory impulses; the alar plate develops into the dorsal horn in the grey matter of the spinal cord" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal spinal cord alar column morphology" EXACT []
synonym: "abnormal spinal cord alar lamina morphology" EXACT []
is_a: MP:0009690 ! abnormal neural tube mantle layer morphology

[Term]
id: MP:0009693
name: abnormal spinal cord basal plate morphology
def: "any structural anomaly of the region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal spinal cord basal column morphology" EXACT []
is_a: MP:0009690 ! abnormal neural tube mantle layer morphology

[Term]
id: MP:0009694
name: abnormal spinal cord commissure morphology
def: "any structural anomaly of any of the nerve fiber tracts that span the midline of the spinal cord" [ISBN:0-683-40008-8]
is_a: MP:0000778 ! abnormal nervous system tract morphology
is_a: MP:0000955 ! abnormal spinal cord morphology

[Term]
id: MP:0009695
name: abnormal spinal cord ventral commissure morphology
def: "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8]
synonym: "abnormal anterior white commissure" EXACT []
synonym: "abnormal spinal cord anterior commissure" EXACT []
synonym: "abnormal spinal cord anterior commissure morphology" EXACT []
synonym: "abnormal ventral spinal commissure morphology" EXACT []
synonym: "abnormal ventral white column morphology" EXACT []
synonym: "abnormal white commissure" RELATED []
is_a: MP:0009694 ! abnormal spinal cord commissure morphology

[Term]
id: MP:0009696
name: abnormal spinal cord grey commissure morphology
def: "any structural anomaly of the band of grey substance spanning the midline of the spinal cord that surrounds the central canal" [ISBN:0-683-40008-8]
synonym: "abnormal anterior grey commissure" RELATED []
synonym: "abnormal posterior grey commissure" NARROW []
synonym: "abnormal spinal cord gray commissure morphology" EXACT []
is_a: MP:0009694 ! abnormal spinal cord commissure morphology

[Term]
id: MP:0009697
name: abnormal copulation behavior
def: "any behavioral anomaly in the act of sexual union that normally enables the transfer of ejaculate (sperm) from male to female, sometimes resulting in the fertilization of an egg" [GO:0007620, MGI:llw2]
synonym: "abnormal coital behavior" EXACT []
synonym: "abnormal coital behaviour" EXACT []
synonym: "abnormal coitus behavior" EXACT []
synonym: "abnormal coitus behaviour" EXACT []
synonym: "abnormal copulation behaviour" EXACT []
synonym: "abnormal copulatory behavior" EXACT []
synonym: "abnormal copulatory behaviour" EXACT []
is_a: MP:0002566 ! abnormal sexual interaction

[Term]
id: MP:0009698
name: heart hemorrhage
def: "bleeding into the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "cardiac bleeding" EXACT []
synonym: "cardiac haemorrhage" EXACT []
synonym: "cardiac hemorrhage" EXACT []
synonym: "heart haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage

[Term]
id: MP:0009699
name: hyperchylomicronemia
def: "increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperchylomicronaemia" EXACT []
synonym: "increased circulating chylomicron numbers" EXACT []
synonym: "increased plasma chylomicron levels" NARROW []
synonym: "increased serum chylomicron numbers" NARROW []
is_a: MP:0010330 ! abnormal circulating lipoprotein level

[Term]
id: MP:0009701
name: abnormal birth body size
alt_id: MP:0009700
def: "anomaly in average body size at birth compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal birth weight/body size" EXACT []
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0009702
name: increased birth body size
def: "increase in average body size at birth compared to controls" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009701 ! abnormal birth body size

[Term]
id: MP:0009703
name: decreased birth body size
def: "reduction in average body size at birth compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced birth body size" EXACT []
is_a: MP:0009701 ! abnormal birth body size

[Term]
id: MP:0009704
name: increased skin squamous cell carcinoma incidence
def: "greater than the expected number of a skin carcinoma derived from stratified squamous epithelium, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "skin squamous cell carcinoma" RELATED []
is_a: MP:0004207 ! increased squamous cell carcinoma incidence
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0009705
name: abnormal midgut morphology
def: "any structural anomaly of the portion of the embryonic gut between the foregut and the hindgut, which originally is open to the yolk sac" [https://orcid.org/0000-0002-6490-7723]
synonym: "midgut abnormalities" EXACT []
synonym: "midgut dysplasia" RELATED []
is_a: MP:0003119 ! abnormal digestive system development

[Term]
id: MP:0009706
name: absent midgut
def: "absence of the portion of the embryonic gut between the foregut and the hindgut" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing midgut" RELATED []
is_a: MP:0009705 ! abnormal midgut morphology

[Term]
id: MP:0009707
name: absent external auditory canal
def: "absence of the canal that connects the outer and middle ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent external meatus" EXACT []
synonym: "external auditory canal atresia" EXACT []
is_a: MP:0006033 ! abnormal external auditory canal morphology

[Term]
id: MP:0009708
name: vaginal septum
def: "a longitudinal or transverse congenital partition within the muscular canal extending from outside of the body to the cervix; usually caused by incomplete fusion of the Mullerian ducts in embryogenesis" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "vaginal septa" EXACT []
is_a: MP:0001144 ! vagina atresia

[Term]
id: MP:0009709
name: hydrometra
def: "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2]
synonym: "hydrouteri" EXACT []
synonym: "hydrouterus" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0009710
name: anhedonia
def: "inability to experience pleasure in response to normally pleasurable stimuli" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014414 ! increased depression-related behavior

[Term]
id: MP:0009711
name: abnormal conditioned place preference behavior
def: "anomaly in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [https://orcid.org/0000-0003-3691-0324, ISBN:0471316393]
synonym: "abnormal conditioned place preference behaviour" EXACT []
is_a: MP:0002062 ! abnormal associative learning

[Term]
id: MP:0009712
name: impaired conditioned place preference behavior
def: "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [https://orcid.org/0000-0003-3691-0324, ISBN:0471316393]
synonym: "decreased conditioned place preference behavior" EXACT []
synonym: "impaired conditioned place preference behaviour" EXACT []
is_a: MP:0009711 ! abnormal conditioned place preference behavior
is_a: MP:0012317 ! impaired conditioning behavior

[Term]
id: MP:0009713
name: enhanced conditioned place preference behavior
def: "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [https://orcid.org/0000-0003-3691-0324, ISBN:0471316393]
synonym: "enhanced conditioned place preference behaviour" EXACT []
synonym: "increased conditioned place preference behavior" EXACT []
is_a: MP:0009711 ! abnormal conditioned place preference behavior
is_a: MP:0012316 ! enhanced conditioning behavior

[Term]
id: MP:0009714
name: thin epidermis stratum basale
def: "reduced thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8]
synonym: "thin basal cell layer" EXACT []
synonym: "thin basal layer" EXACT []
synonym: "thin columnar layer" EXACT []
synonym: "thin germinative layer" EXACT []
synonym: "thin palisade layer" EXACT []
synonym: "thin stratum basale epidermis" EXACT []
synonym: "thin stratum cylindricum" EXACT []
synonym: "thin stratum germinativum" EXACT []
is_a: MP:0001231 ! abnormal epidermis stratum basale morphology

[Term]
id: MP:0009715
name: thick epidermis stratum basale
def: "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8]
synonym: "thick basal cell layer" EXACT []
synonym: "thick basal layer" EXACT []
synonym: "thick columnar layer" EXACT []
synonym: "thick germinative layer" EXACT []
synonym: "thick palisade layer" EXACT []
synonym: "thick stratum basale epidermis" EXACT []
synonym: "thick stratum cylindricum" EXACT []
synonym: "thick stratum germinativum" EXACT []
is_a: MP:0001231 ! abnormal epidermis stratum basale morphology

[Term]
id: MP:0009716
name: abnormal subcommissural organ morphology
def: "any structural anomaly of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin" [MESH:A08.713.810]
synonym: "abnormal SCO" EXACT []
is_a: MP:0013563 ! abnormal secretory circumventricular organ morphology

[Term]
id: MP:0009717
name: absent subcommissural organ
def: "absence of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin" [MESH:A08.713.810]
synonym: "absent SCO" EXACT []
is_a: MP:0009716 ! abnormal subcommissural organ morphology

[Term]
id: MP:0009718
name: absent Purkinje cell layer
def: "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2]
is_a: MP:0000875 ! abnormal cerebellar Purkinje cell layer

[Term]
id: MP:0009719
name: reduced cerebellar foliation
def: "the cerebellar lobules are reduced in size or number" [MGI:llw2]
synonym: "reduced cerebellum foliation" EXACT []
synonym: "reduced folia" EXACT []
is_a: MP:0000857 ! abnormal cerebellar foliation

[Term]
id: MP:0009720
name: abnormal mammary gland pattern
def: "aberration in the spacing and arrangement of mammary glands that differentiate during early embryogenesis as it relates to the norm for the species" [MGI:llw2]
synonym: "abnormal mammary gland number" RELATED []
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0009721
name: increased mammary gland number
def: "greater than the expected number of the specialized accessory gland of the skin of mammals that secretes milk" [MGI:llw2]
synonym: "increased breast number" EXACT []
synonym: "increased Brustdruese number" EXACT []
synonym: "increased glandula mammaria number" EXACT []
synonym: "increased Lactiferous gland number" EXACT []
synonym: "increased lactiferous gland number" EXACT []
synonym: "increased Lobe of breast number" EXACT []
synonym: "increased lobe of breast number" EXACT []
synonym: "increased Lobe of mammary gland number" EXACT []
synonym: "increased lobe of mammary gland number" EXACT []
synonym: "increased mamma number" EXACT []
synonym: "increased mammae number" EXACT []
synonym: "polymastia" EXACT []
synonym: "supernumerary mammary glands" BROAD []
is_a: MP:0013714 ! abnormal mammary gland number

[Term]
id: MP:0009722
name: abnormal nipple development
def: "an anomaly in the differentiation of the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2]
synonym: "abnormal papilla mammae development" EXACT []
synonym: "abnormal papilla of breast development" EXACT []
synonym: "abnormal teat development" EXACT []
synonym: "abnormal thele development" EXACT []
synonym: "abnormal thelium development" EXACT []
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0009723
name: increased nipple number
def: "greater than the expected number of structures located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open; normal female mice have five pairs of mammary glands and nipples (males have no nipples); two pairs of nipples are situated in the abdomino-inguinal region (inguinal group) and three pairs in the ventral thoracic region (pectoral or thoracic group)" [MGI:llw2]
subset: CvDC_Terms
synonym: "hyperthelia" EXACT []
synonym: "polythelia" EXACT []
synonym: "supernumerary nipples" EXACT []
synonym: "supernumerary papilla mammae" EXACT []
synonym: "supernumerary teat" EXACT []
synonym: "supernumerary thele" EXACT []
synonym: "supernumerary thelium" EXACT []
xref: Fyler:4234
is_a: MP:0006078 ! abnormal nipple morphology

[Term]
id: MP:0009724
name: ectopic nipples
def: "abnormal location of structures normally located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2]
synonym: "ectopic papilla mammae" EXACT []
synonym: "ectopic papilla of breast" EXACT []
synonym: "ectopic teat" EXACT []
synonym: "ectopic thele" EXACT []
synonym: "ectopic thelium" EXACT []
is_a: MP:0006078 ! abnormal nipple morphology
is_a: MP:0009722 ! abnormal nipple development

[Term]
id: MP:0009725
name: absent lens vesicle
def: "absence of the ectodermal invagination that forms opposite the optic cup in the primordium of the lens of the eye" [ISBN:0-12-402035-6, MGI:llw2]
synonym: "absent lenticular vesicle" EXACT []
synonym: "failure of lens vesicle induction" RELATED []
is_a: MP:0001292 ! abnormal lens vesicle development

[Term]
id: MP:0009726
name: abnormal primordial meninx morphology
def: "any structural anomaly of the outermost mesenchymal covering of the developing brain and spinal cord that is composed of tough fibrous connective tissue from which the arachnoid mater, pia mater and dura mater are formed" [MGI:llw2]
synonym: "abnormal meninx primitiva" EXACT []
is_a: MP:0000913 ! abnormal brain development

[Term]
id: MP:0009727
name: abnormal navicular morphology
def: "any structural anomaly of the oval-shaped tarsal bone found between the talus and the 3 cuneiform bones" [MGI:llw2]
synonym: "abnormal central tarsal bone morphology" EXACT []
synonym: "abnormal centrale morphology" RELATED []
is_a: MP:0005104 ! abnormal tarsal bone morphology

[Term]
id: MP:0009728
name: abnormal calcaneum morphology
def: "any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal calcaneal bone morphology" EXACT []
synonym: "abnormal calcaneus morphology" EXACT []
synonym: "abnormal fibular tarsal bone" EXACT []
synonym: "abnormal fibulare morphology" EXACT []
synonym: "abnormal heel bone" NARROW []
synonym: "abnormal hock bone" NARROW []
synonym: "abnormal os calcis" EXACT []
is_a: MP:0005104 ! abnormal tarsal bone morphology

[Term]
id: MP:0009729
name: absent tarsus bones
def: "absence of the eight bones of the instep of the paw/foot: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent tarsal bones" EXACT []
is_a: MP:0005104 ! abnormal tarsal bone morphology

[Term]
id: MP:0009731
name: abnormal offspring retrieval
def: "any anomaly in the ability of a female to collect stray offspring and return them to a defined location, such as a nest or den" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001386 ! abnormal maternal nurturing

[Term]
id: MP:0009732
name: ventricular premature beat
def: "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "extrasystole" EXACT []
synonym: "premature ventricular complex" RELATED []
synonym: "premature ventricular contraction" EXACT []
synonym: "PVC" RELATED []
synonym: "ventricular ectopic beat" EXACT []
synonym: "ventricular premature contraction" EXACT []
synonym: "VPB" EXACT []
synonym: "VPC" EXACT []
is_a: MP:0001636 ! irregular heartbeat

[Term]
id: MP:0009733
name: absent nipple
def: "absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8]
synonym: "absent papilla mammae" EXACT []
synonym: "absent papilla of breast" EXACT []
synonym: "absent teat" EXACT []
synonym: "absent thele" EXACT []
synonym: "absent thelium" EXACT []
is_a: MP:0006078 ! abnormal nipple morphology

[Term]
id: MP:0009734
name: abnormal prostate gland duct morphology
def: "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8]
synonym: "abnormal prostatic duct morphology" EXACT []
xref: MA:0002785
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0009735
name: abnormal prostate gland development
def: "anomaly in the formation or pattering of the of the prostate gland" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001158 ! abnormal prostate gland morphology
is_a: MP:0003936 ! abnormal reproductive system development
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0009736
name: abnormal prostate gland branching morphogenesis
def: "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal prostate gland ductal branching" RELATED []
is_a: MP:0009735 ! abnormal prostate gland development

[Term]
id: MP:0009737
name: prostate gland cyst
def: "presence of one or more benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "cystic prostate gland" EXACT []
synonym: "prostate gland cysts" EXACT []
is_a: MP:0001158 ! abnormal prostate gland morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0009738
name: enlarged prostate gland anterior lobe
def: "increased size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [https://orcid.org/0000-0003-3691-0324, PMID:12645922, PMID:3308446]
synonym: "enlarged AP" EXACT []
synonym: "enlarged coagulating gland" EXACT []
synonym: "increased prostate gland anterior lobe size" EXACT []
is_a: MP:0001163 ! abnormal prostate gland anterior lobe morphology

[Term]
id: MP:0009739
name: enlarged prostate gland dorsolateral lobe
def: "increased size of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [https://orcid.org/0000-0003-3691-0324, PMID:12645922, PMID:3308446]
synonym: "enlarged DLP" RELATED []
synonym: "enlarged dorsolateral prostate" EXACT []
synonym: "increased prostate gland dorsolateral lobe size" EXACT []
is_a: MP:0009381 ! abnormal prostate gland dorsolateral lobe morphology

[Term]
id: MP:0009740
name: small prostate gland dorsolateral lobe
def: "reduced size of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [PMID:12645922, PMID:3308446]
synonym: "decreased prostate gland dorsolateral lobe size" EXACT []
synonym: "small DLP" EXACT []
synonym: "small dorsolateral prostate" EXACT []
is_a: MP:0009381 ! abnormal prostate gland dorsolateral lobe morphology

[Term]
id: MP:0009741
name: ectopic mammary gland
def: "one or more of the expected number of mammary glands that differentiate during early embryogenesis is/ are not located according to the normal arrangement" [MGI:llw2]
is_a: MP:0009720 ! abnormal mammary gland pattern

[Term]
id: MP:0009742
name: increased cornea stroma thickness
def: "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2]
synonym: "increased corneal stroma thickness" EXACT []
is_a: MP:0005300 ! abnormal cornea stroma morphology

[Term]
id: MP:0009743
name: preaxial polydactyly
def: "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
is_a: MP:0000562 ! polydactyly

[Term]
id: MP:0009744
name: postaxial polydactyly
def: "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
is_a: MP:0000562 ! polydactyly

[Term]
id: MP:0009745
name: abnormal behavioral response to xenobiotic
def: "any anomaly in the behavioral response induced by a compound foreign to living organisms, such as consumption preference, induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal behavioral response to xenobiotics" EXACT []
synonym: "abnormal behavioural response to xenobiotic" EXACT []
synonym: "abnormal behavioural response to xenobiotics" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0009746
name: enhanced behavioral response to xenobiotic
def: "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioral response to xenobiotics" EXACT []
synonym: "enhanced behavioural response to xenobiotic" EXACT []
synonym: "enhanced behavioural response to xenobiotics" EXACT []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0009747
name: impaired behavioral response to xenobiotic
def: "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioral response to xenobiotics" EXACT []
synonym: "impaired behavioural response to xenobiotic" EXACT []
synonym: "impaired behavioural response to xenobiotics" EXACT []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0009748
name: abnormal behavioral response to addictive substance
def: "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal behavioural response to addictive substance" EXACT []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0009749
name: enhanced behavioral response to addictive substance
def: "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioural response to addictive substance" EXACT []
is_a: MP:0009746 ! enhanced behavioral response to xenobiotic
is_a: MP:0009748 ! abnormal behavioral response to addictive substance

[Term]
id: MP:0009750
name: impaired behavioral response to addictive substance
def: "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioural response to addictive substance" EXACT []
is_a: MP:0009747 ! impaired behavioral response to xenobiotic
is_a: MP:0009748 ! abnormal behavioral response to addictive substance

[Term]
id: MP:0009751
name: enhanced behavioral response to alcohol
def: "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioural response to alcohol" EXACT []
is_a: MP:0009749 ! enhanced behavioral response to addictive substance
is_a: MP:0020157 ! abnormal behavioral response to alcohol

[Term]
id: MP:0009752
name: enhanced behavioral response to nicotine
def: "increased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioural response to nicotine" EXACT []
is_a: MP:0009749 ! enhanced behavioral response to addictive substance
is_a: MP:0020160 ! abnormal behavioral response to nicotine

[Term]
id: MP:0009753
name: enhanced behavioral response to morphine
def: "increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioural response to morphine" EXACT []
is_a: MP:0009749 ! enhanced behavioral response to addictive substance
is_a: MP:0020159 ! abnormal behavioral response to morphine

[Term]
id: MP:0009754
name: enhanced behavioral response to cocaine
def: "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced behavioural response to cocaine" EXACT []
is_a: MP:0009749 ! enhanced behavioral response to addictive substance
is_a: MP:0020158 ! abnormal behavioral response to cocaine

[Term]
id: MP:0009755
name: impaired behavioral response to alcohol
def: "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioural response to alcohol" EXACT []
is_a: MP:0009750 ! impaired behavioral response to addictive substance
is_a: MP:0020157 ! abnormal behavioral response to alcohol

[Term]
id: MP:0009756
name: impaired behavioral response to nicotine
def: "decreased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioural response to nicotine" EXACT []
is_a: MP:0009750 ! impaired behavioral response to addictive substance
is_a: MP:0020160 ! abnormal behavioral response to nicotine

[Term]
id: MP:0009757
name: impaired behavioral response to morphine
def: "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioural response to morphine" EXACT []
is_a: MP:0009750 ! impaired behavioral response to addictive substance
is_a: MP:0020159 ! abnormal behavioral response to morphine

[Term]
id: MP:0009758
name: impaired behavioral response to cocaine
def: "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired behavioural response to cocaine" EXACT []
is_a: MP:0009750 ! impaired behavioral response to addictive substance
is_a: MP:0020158 ! abnormal behavioral response to cocaine

[Term]
id: MP:0009759
name: abnormal hair follicle bulge morphology
def: "any structural anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen) and contains the hair follicle stem cells" [ISBN:0-8493-8372-2, MGI:llw2, PMID:19211055]
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology

[Term]
id: MP:0009760
name: abnormal mitotic spindle morphology
def: "any structural anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691]
synonym: "abnormal mitotic spindle apparatus" EXACT []
synonym: "abnormal mitotic spindle fibers" EXACT []
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0009761
name: abnormal meiotic spindle morphology
def: "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009762
name: abnormal mitotic spindle assembly checkpoint
def: "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
synonym: "abnormal mitotic SAC" EXACT []
is_a: MP:0004045 ! abnormal cell cycle checkpoint function
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0009763
name: increased susceptibility to induced morbidity/mortality
def: "decrease in the amount of an external agent required to cause death or diseased state" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to induced morbidity/mortality" EXACT []
synonym: "decreased survival following induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to induced morbidity/mortality" EXACT []
is_a: MP:0020148 ! abnormal susceptibility to induced morbidity/mortality

[Term]
id: MP:0009764
name: decreased susceptibility to induced morbidity/mortality
def: "increase in the amount of an external agent required to cause death or diseased state" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sensitivity to induced morbidity/mortality" EXACT []
synonym: "increased resistance to induced morbidity/mortality" EXACT []
synonym: "increased survival following induced morbidity/mortality" EXACT []
is_a: MP:0020148 ! abnormal susceptibility to induced morbidity/mortality

[Term]
id: MP:0009765
name: abnormal xenobiotic induced morbidity/mortality
def: "any anomaly in induction of a diseased state or death caused by a compound foreign to living organisms" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0008872 ! abnormal physiological response to xenobiotic

[Term]
id: MP:0009766
name: increased susceptibility to xenobiotic induced morbidity/mortality
def: "decrease in the amount of a compound foreign to living organisms required to cause death or diseased state" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to xenobiotic induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to xenobiotic induced morbidity/mortality" EXACT []
is_a: MP:0009763 ! increased susceptibility to induced morbidity/mortality
is_a: MP:0009765 ! abnormal xenobiotic induced morbidity/mortality

[Term]
id: MP:0009767
name: decreased susceptibility to xenobiotic induced morbidity/mortality
def: "increase in the amount of a compound foreign to living organisms required to cause death or diseased state" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sensitivity to xenobiotic induced morbidity/mortality" EXACT []
synonym: "increased resistance to xenobiotic induced morbidity/mortality" EXACT []
is_a: MP:0009764 ! decreased susceptibility to induced morbidity/mortality
is_a: MP:0009765 ! abnormal xenobiotic induced morbidity/mortality

[Term]
id: MP:0009768
name: impaired somite development
def: "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001688 ! abnormal somite development

[Term]
id: MP:0009769
name: abnormal meiotic spindle assembly checkpoint
def: "an anomaly in the process that normally prevents inaccurate segregation of chromosomes by inhibiting cell-cycle progression in response to a signal generated by meiotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:18596218]
is_a: MP:0001930 ! abnormal meiosis

[Term]
id: MP:0009770
name: abnormal optic chiasm morphology
def: "any structural anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2]
synonym: "abnormal optic chiasma" EXACT []
synonym: "abnormal optic decussation" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0009771
name: absent optic chiasm
def: "absence of the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2]
synonym: "absent optic chiasma" EXACT []
synonym: "absent optic decussation" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology

[Term]
id: MP:0009772
name: abnormal retina development
def: "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2]
synonym: "abnormal retinal development" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0009773
name: absent retina
def: "absence of the nerve layer lining the back of the eye that senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2]
is_a: MP:0001325 ! abnormal retina morphology

[Term]
id: MP:0009774
name: abnormal behavioral withdrawal response
def: "anomaly in the intensity, duration, or type of behaviors displayed after discontinuation of an addictive substance" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal behavioural withdrawal response" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance

[Term]
id: MP:0009775
name: increased behavioral withdrawal response
def: "increase in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased behavioural withdrawal response" EXACT []
is_a: MP:0009774 ! abnormal behavioral withdrawal response

[Term]
id: MP:0009776
name: decreased behavioral withdrawal response
def: "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased behavioural withdrawal response" EXACT []
is_a: MP:0009774 ! abnormal behavioral withdrawal response

[Term]
id: MP:0009777
name: abnormal behavioral response to anesthetic
def: "anomaly in the behavioral changes that follow exposure to an anesthetizing agent" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal behavioural response to anaesthetic" EXACT []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic

[Term]
id: MP:0009778
name: impaired behavioral response to anesthetic
def: "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [https://orcid.org/0000-0003-4606-0597]
synonym: "impaired behavioural response to anaesthetic" EXACT []
is_a: MP:0009747 ! impaired behavioral response to xenobiotic
is_a: MP:0009777 ! abnormal behavioral response to anesthetic

[Term]
id: MP:0009779
name: enhanced behavioral response to anesthetic
def: "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced behavioural response to anaesthetic" EXACT []
is_a: MP:0009746 ! enhanced behavioral response to xenobiotic
is_a: MP:0009777 ! abnormal behavioral response to anesthetic

[Term]
id: MP:0009780
name: abnormal chondrocyte physiology
def: "any functional anomaly of a polymorphic cell that forms cartilage" [GO:0035988, ISBN:0-683-40008-8]
is_a: MP:0031306 ! abnormal cartilage physiology

[Term]
id: MP:0009781
name: abnormal preimplantation embryo development
def: "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2]
synonym: "abnormal pre-implantation embryo development" EXACT []
is_a: MP:0001672 ! abnormal embryo development

[Term]
id: MP:0009782
name: abnormal basicranium angle
def: "a deviation from the expected angle formed by a line representing the floor of the anterior cranial fossa intersecting a line representing the axis of the clivus of the base of the skull" [MGI:llw2]
synonym: "abnormal cranial base angle" EXACT []
is_a: MP:0010029 ! abnormal basicranium morphology

[Term]
id: MP:0009783
name: abnormal melanoblast morphology
def: "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
is_a: MP:0009845 ! abnormal neural crest cell morphology

[Term]
id: MP:0009784
name: abnormal melanoblast migration
def: "any anomaly in the movement of the cells that originate from the neural crest and differentiate into pigment cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002950 ! abnormal neural crest cell migration
is_a: MP:0030904 ! abnormal melanoblast physiology

[Term]
id: MP:0009785
name: abnormal susceptibility to infection induced morbidity/mortality
def: "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal infection induced morbidity/mortality" EXACT []
synonym: "abnormal sensitivity to infection induced morbidity/mortality" EXACT []
synonym: "altered resistance to infection induced morbidity/mortality" RELATED []
synonym: "altered susceptibility to infection induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0001793 ! abnormal susceptibility to infection

[Term]
id: MP:0009786
name: decreased susceptibility to infection induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sensitivity to infection induced morbidity/mortality" EXACT []
synonym: "increased resistance to infection induced morbidity/mortality" EXACT []
is_a: MP:0002409 ! decreased susceptibility to infection
is_a: MP:0009785 ! abnormal susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009787
name: increased susceptibility to infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to infection induced morbidity/mortality" EXACT []
is_a: MP:0002406 ! increased susceptibility to infection
is_a: MP:0009785 ! abnormal susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009788
name: increased susceptibility to bacterial infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to bacterial infection induced morbidity/mortality" RELATED []
synonym: "increased bacterial infection induced morbidity/mortality" RELATED []
synonym: "increased sensitivityy to bacterial infection induced morbidity/mortality" EXACT []
is_a: MP:0002412 ! increased susceptibility to bacterial infection
is_a: MP:0009787 ! increased susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009789
name: decreased susceptibility to bacterial infection induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased bacterial infection induced morbidity/mortality" EXACT []
synonym: "decreased sensitivity to bacterial infection induced morbidity/mortality" EXACT []
synonym: "increased resistance to bacterial infection induced morbidity/mortality" EXACT []
is_a: MP:0002411 ! decreased susceptibility to bacterial infection
is_a: MP:0009786 ! decreased susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009790
name: decreased susceptibility to viral infection induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sensitivity to viral infection induced morbidity/mortality" EXACT []
synonym: "decreased viral infection induced morbidity/mortality" EXACT []
synonym: "increased resistance to viral infection induced morbidity/mortality" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0009786 ! decreased susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009791
name: increased susceptibility to viral infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to viral infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to viral infection induced morbidity/mortality" EXACT []
synonym: "increased viral infection induced morbidity/mortality" EXACT []
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0009787 ! increased susceptibility to infection induced morbidity/mortality

[Term]
id: MP:0009792
name: seborrheic dermatitis
def: "an inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp or inside the ear, with or without reddened skin" [MGI:llw2]
is_a: MP:0001194 ! dermatitis

[Term]
id: MP:0009793
name: sebaceous gland hypertrophy
def: "increase in the bulk size of the sebum secreting glands of the hair shaft due to cell enlargement" [MGI:llw2]
is_a: MP:0000652 ! enlarged sebaceous gland

[Term]
id: MP:0009794
name: sebaceous gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the sebaceous glands, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic sebaceous gland" EXACT []
is_a: MP:0000652 ! enlarged sebaceous gland

[Term]
id: MP:0009795
name: epidermal spongiosis
def: "intercellular edema within the epidermis" [MGI:llw2]
is_a: MP:0001786 ! skin edema

[Term]
id: MP:0009796
name: abnormal base-excision repair
def: "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
synonym: "abnormal BER" EXACT []
is_a: MP:0008058 ! abnormal DNA repair

[Term]
id: MP:0009797
name: abnormal mismatch repair
def: "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
synonym: "abnormal long patch mismatch repair system" EXACT []
synonym: "abnormal mismatch repair, MutL-like pathway" EXACT []
synonym: "abnormal MMR" EXACT []
is_a: MP:0008058 ! abnormal DNA repair

[Term]
id: MP:0009798
name: abnormal ophthalmic nerve morphology
def: "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal CN V1" EXACT []
synonym: "abnormal V1 nerve morphology" EXACT []
is_a: MP:0001065 ! abnormal trigeminal nerve morphology

[Term]
id: MP:0009799
name: abnormal maxillary nerve morphology
def: "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal CN V2" EXACT []
synonym: "abnormal V2 nerve morphology" RELATED []
is_a: MP:0001065 ! abnormal trigeminal nerve morphology

[Term]
id: MP:0009800
name: abnormal mandibular nerve morphology
def: "any structural anomaly of the motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal CN V3" EXACT []
synonym: "abnormal V3 nerve morphology" EXACT []
is_a: MP:0001065 ! abnormal trigeminal nerve morphology

[Term]
id: MP:0009801
name: abnormal hair cortex keratinization
def: "any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity" [ISBN:0-8493-8372-2, MGI:llw2]
is_a: MP:0003811 ! abnormal hair cortex morphology

[Term]
id: MP:0009802
name: abnormal median aperture morphology
def: "any structural anomaly in the large midline opening of the posterior inferior part of the roof of the fourth ventricle that connects the fourth ventricle to the posterior cerebromedullary cistern and the spinal cord" [ISBN:0-683-40008-8]
synonym: "abnormal arachnoid foramen morhpology" EXACT []
synonym: "abnormal foramen of Magendie morphology" EXACT []
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0009803
name: abnormal lateral aperture morphology
def: "any structural anomaly of the two lateral openings of the fourth ventricle into the subarachnoid space at the cerebellopontine angle" [ISBN:0-683-40008-8]
synonym: "abnormal foramen of Key-Retzius morphology" EXACT []
synonym: "abnormal foramen of Luschka morphology" EXACT []
synonym: "abnormal foramen of Retzius morphology" EXACT []
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0009804
name: abnormal brain interventricular foramen morphology
def: "any structural anomaly of the paired channels that connect the lateral and third ventricles and allows cerebrospinal fluid produced in the lateral ventricles to flow into the third ventricle" [ISBN:0-683-40008-8]
synonym: "abnormal foramen of Monro morphology" EXACT []
synonym: "abnormal foramina of Monro morphology" EXACT []
synonym: "abnormal interventricular foramen of CNS morphology" EXACT []
synonym: "abnormal interventricular foramina of Monro morphology" EXACT []
is_a: MP:0002200 ! abnormal brain ventricular system morphology

[Term]
id: MP:0009805
name: absent median aperture
def: "absence of the large midline opening of the posterior inferior part of the roof of the fourth ventricle that connects the fourth ventricle to the posterior cerebromedullary cistern and the spinal cord" [ISBN:0-683-40008-8]
synonym: "absent arachnoid foramen" EXACT []
synonym: "absent foramen of Magendie" RELATED []
is_a: MP:0009802 ! abnormal median aperture morphology

[Term]
id: MP:0009806
name: abnormal otic vesicle morphology
def: "any structural anomaly of the paired sacs of invaginated ectoderm that develop into the membraneous labyrinth of the inner ear" [ISBN:0-683-40008-8]
synonym: "abnormal acoustic vesicle morphology" EXACT []
synonym: "abnormal auditory vesicle morphology" EXACT []
synonym: "abnormal otocyst morphology" EXACT []
is_a: MP:0003938 ! abnormal ear development

[Term]
id: MP:0009807
name: abnormal pelvic ligament morphology
def: "any structural anomaly of the dorsal sacroiliac, the sacrotuberal and/or the iliolumbar ligaments associated with the bony ring formed by the pair of hip bones fused at the symphysis and their firm articulation with the sacrum" [MGI:llw2]
is_a: MP:0005504 ! abnormal ligament morphology

[Term]
id: MP:0009808
name: decreased oligodendrocyte number
def: "reduced number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:llw2]
synonym: "decreased oligodendroglia number" EXACT []
synonym: "decreased oligodendroglial cell number" EXACT []
synonym: "decreased oligoglia number" EXACT []
synonym: "decreased oligoglial cell number" EXACT []
synonym: "reduced oligodendrocyte number" EXACT []
synonym: "reduced oligodendroglia number" EXACT []
synonym: "reduced oligodendroglial cell number" EXACT []
synonym: "reduced oligoglia number" EXACT []
synonym: "reduced oligoglial cell number" EXACT []
is_a: MP:0000953 ! abnormal oligodendrocyte morphology

[Term]
id: MP:0009809
name: abnormal urine uric acid level
def: "anomaly in the amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal urine urate level" RELATED []
is_a: MP:0009643 ! abnormal urine homeostasis

[Term]
id: MP:0009810
name: increased urine uric acid level
def: "greater amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyperlithuria" RELATED []
synonym: "hyperuricosuria" EXACT []
synonym: "hyperuricuria" RELATED []
synonym: "lithuria" RELATED []
synonym: "uricosuria" EXACT []
is_a: MP:0009809 ! abnormal urine uric acid level

[Term]
id: MP:0009811
name: abnormal prostaglandin level
def: "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8]
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0009812
name: abnormal bradykinin level
def: "abnormal concentration of a potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability" [ISBN:0-397-51047-0]
is_a: MP:0008835 ! abnormal intercellular signaling peptide or protein level

[Term]
id: MP:0009813
name: abnormal leukotriene level
def: "abnormal concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0]
synonym: "abnormal leucotriene level" EXACT []
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0009814
name: increased prostaglandin level
def: "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8]
is_a: MP:0009811 ! abnormal prostaglandin level

[Term]
id: MP:0009815
name: decreased prostaglandin level
def: "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8]
synonym: "reduced prostaglandin level" EXACT []
is_a: MP:0009811 ! abnormal prostaglandin level
is_a: MP:0014461 ! decreased lipid level

[Term]
id: MP:0009816
name: increased leukotriene level
def: "increased concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0]
synonym: "increased leucotriene level" EXACT []
is_a: MP:0009813 ! abnormal leukotriene level
is_a: MP:0014460 ! increased lipid level

[Term]
id: MP:0009817
name: decreased leukotriene level
def: "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0]
synonym: "decreased leucotriene level" EXACT []
synonym: "reduced leucotriene level" EXACT []
synonym: "reduced leukotriene level" EXACT []
is_a: MP:0009813 ! abnormal leukotriene level
is_a: MP:0014461 ! decreased lipid level

[Term]
id: MP:0009818
name: abnormal thromboxane level
def: "anomalous concentration in the body of any of several compounds, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0009819
name: abnormal circulating androgen level
def: "anomaly in the blood concentration of any of the steroid hormones that control development and maintenance of masculine characteristics" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal circulating androgenic hormone level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level

[Term]
id: MP:0009820
name: abnormal liver vasculature morphology
def: "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal hepatic vasculature morphology" EXACT []
synonym: "hepatic vasculature dysplasia" NARROW []
synonym: "liver vasculature dysplasia" NARROW []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0009821
name: abnormal vestibular aqueduct morphology
def: "any structural anomaly in the small bony canal that surrounds the endolymphatic duct canal and links the vestibule of the inner ear to the posterior part of the internal surface of the petrous temporal bone" [MGI:llw2]
synonym: "abnormal aqueduct of Cotunnius morphology" EXACT []
synonym: "abnormal Cotunnius canal morphology" EXACT []
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0030309 ! abnormal posterior cranial fossa morphology

[Term]
id: MP:0009822
name: abnormal subarcuate fossa morphology
def: "any structural anomaly of the irregular depression found on the posterior inner surface of the petrous portion of the temporal bone just below its crest and above and lateral to the internal acoustic meatus" [ISBN:0-683-40008-8]
synonym: "abnormal floccular fossa" EXACT []
is_a: MP:0030306 ! abnormal cranial fossa morphology
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology

[Term]
id: MP:0009823
name: abnormal sphingomyelin level
def: "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2]
is_a: MP:0004777 ! abnormal phospholipid level
is_a: MP:0012230 ! abnormal sphingolipid level

[Term]
id: MP:0009824
name: spermatic granuloma
def: "a granulomatous nodular lesion that appears in the region of epididymis and can be large enough to totally occlude the epididymal lumen; sperm granulomas are rounded or irregular in shape, and contain dense aggregates of immune cells and degenerating sperm resulting from an autoimmune response against sperm-associated antigens exposed following biochemical or surgical insult (e.g. vasectomy) to the epididymal epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "sperm granuloma" EXACT []
is_a: MP:0002500 ! granulomatous inflammation
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0009825
name: cornea ulcer
def: "an area of tissue erosion in the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [https://orcid.org/0000-0003-4606-0597]
synonym: "corneal ulcer" EXACT []
synonym: "corneal ulceration" EXACT []
synonym: "tunica cornea ulcer" EXACT []
synonym: "ulceration of the cornea" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology

[Term]
id: MP:0009826
name: abnormal dermis reticular layer collagen network
def: "an anomaly in the amount or arrangement of the criss-crossing collagen fibers that form a strong elastic network normally arranged in parallel to the surface of the skin" [MGI:llw2]
is_a: MP:0005081 ! abnormal dermis reticular layer morphology

[Term]
id: MP:0009827
name: skin detachment
def: "loss of sections of skin either spontaneously or after gentle handling" [https://orcid.org/0000-0003-4606-0597]
synonym: "detached skin" EXACT []
synonym: "skin sloughing" EXACT []
is_a: MP:0009931 ! abnormal skin appearance

[Term]
id: MP:0009828
name: increased tumor latency
def: "later onset of tumor occurrence than expected" [MGI:mberry]
synonym: "delayed tumor appearance" EXACT []
synonym: "delayed tumour appearance" EXACT []
synonym: "increased tumour latency" EXACT []
is_a: MP:0010307 ! abnormal tumor latency

[Term]
id: MP:0009829
name: enlarged eye anterior chamber
def: "increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry]
synonym: "increased eye anterior chamber size" EXACT []
is_a: MP:0005205 ! abnormal eye anterior chamber morphology

[Term]
id: MP:0009830
name: abnormal sperm connecting piece morphology
def: "any structural anomaly in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum" [PMID:14581499]
synonym: "abnormal sperm coupling apparatus morphology" EXACT [PMID:30032984]
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009831
name: abnormal sperm midpiece morphology
def: "any structural anomaly of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009832
name: abnormal sperm mitochondrial sheath morphology
def: "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
is_a: MP:0009831 ! abnormal sperm midpiece morphology

[Term]
id: MP:0009833
name: absent sperm mitochondrial sheath
def: "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
synonym: "absent sperm mitochondria" EXACT []
is_a: MP:0009832 ! abnormal sperm mitochondrial sheath morphology

[Term]
id: MP:0009834
name: abnormal sperm annulus morphology
def: "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
synonym: "abnormal sperm anulus morphology" EXACT []
is_a: MP:0009831 ! abnormal sperm midpiece morphology

[Term]
id: MP:0009835
name: absent sperm annulus
def: "absence of the ring-like, filamentous structure located at the midpiece-principal piece junction of the sperm flagellum, usually associated with a bent tail morphology" [PMID:14581499]
synonym: "absent sperm anulus" EXACT []
is_a: MP:0009834 ! abnormal sperm annulus morphology

[Term]
id: MP:0009836
name: abnormal sperm principal piece morphology
def: "any structural anomaly in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009837
name: abnormal sperm end piece morphology
def: "any structural anomaly of the short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane" [PMID:14581499]
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009838
name: abnormal sperm axoneme morphology
def: "any structural anomaly of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
synonym: "abnormal flagellar axoneme" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009839
name: multiflagellated sperm
def: "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [https://orcid.org/0000-0002-6490-7723]
synonym: "multi-flagellate sperm" EXACT []
synonym: "multi-flagellated sperm" EXACT []
synonym: "multi-tailed sperm" EXACT []
synonym: "multiflagellate sperm" EXACT []
synonym: "multiple sperm flagella" EXACT []
synonym: "multiple sperm tails" EXACT []
synonym: "multiple tailed sperm" EXACT []
synonym: "sperm multiflagellation" EXACT []
synonym: "sperm with multiflagella" EXACT []
synonym: "supernumerary sperm flagella" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology

[Term]
id: MP:0009840
name: abnormal foam cell morphology
def: "any structural anomaly of a cell with a vacuolated appearance due to abnormal deposition and retention of lipoproteins, and typically seen in atherolosclerotic lesions, as well as other conditions, and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow" [CL:0000891, MGI:llw2]
is_a: MP:0000358 ! abnormal cell morphology

[Term]
id: MP:0009841
name: foam cell reticulosis
def: "an increase in cells with a vacuolated appearance due to abnormal deposition and retention of lipoproteins and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow" [MGI:llw2]
synonym: "increased foam cell number" EXACT []
is_a: MP:0009840 ! abnormal foam cell morphology

[Term]
id: MP:0009842
name: abnormal neural crest cell proliferation
def: "any anomaly in the ability of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult, to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal NCC proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0012745 ! abnormal neural crest cell physiology

[Term]
id: MP:0009843
name: decreased neural crest cell number
def: "reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
synonym: "reduced neural crest cell number" EXACT []
is_a: MP:0009845 ! abnormal neural crest cell morphology

[Term]
id: MP:0009844
name: abnormal neural crest cell apoptosis
def: "change in the timing or the number of neural crest cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal NCC apoptosis" EXACT []
is_a: MP:0012745 ! abnormal neural crest cell physiology
is_a: MP:0013503 ! abnormal embryonic tissue cell apoptosis

[Term]
id: MP:0009845
name: abnormal neural crest cell morphology
def: "any structural anomaly of the transient and highly migratory group of cells that delaminate in early embryonic development from the dorsal neural tube and give rise to a variety of differentiated cell types, including (1) the neurons and glial cells of the sensory, sympathetic, and parasympathetic nervous systems, (2) the epinephrine-producing (medulla) cells of the adrenal gland, (3) the pigment-containing cells of the epidermis, and (4) many of the skeletal and connective tissue components of the head" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal NCC morphology" RELATED []
is_a: MP:0002400 ! abnormal multipotent stem cell morphology
is_a: MP:0009846 ! abnormal neural crest morphology

[Term]
id: MP:0009846
name: abnormal neural crest morphology
def: "any structural anomaly of the specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002151 ! abnormal neural tube morphology

[Term]
id: MP:0009847
name: abnormal scrotum pigmentation
def: "anomaly in the coloration of the scrotum due to changes in the amount, shape, or distribution of cells producing pigment" [MGI:llw2]
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0002669 ! abnormal scrotum morphology

[Term]
id: MP:0009848
name: increased horizontal stereotypic behavior
def: "increase in the frequency of bursts of horizontal crossings (greater than one per second) in a time period" [PMID:19720087]
is_a: MP:0001409 ! increased stereotypic behavior

[Term]
id: MP:0009849
name: increased vertical stereotypic behavior
def: "increase in the frequency of bursts of vertical crossings (greater than one per second) in a time period" [PMID:19720087]
is_a: MP:0001409 ! increased stereotypic behavior

[Term]
id: MP:0009850
name: embryonic lethality between implantation and placentation
def: "death anytime between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:llw2]
subset: IMPC_Prenatal
is_a: MP:0013292 ! embryonic lethality prior to organogenesis

[Term]
id: MP:0009851
name: abnormal Sertoli cell phagocytosis
def: "altered ability of the Sertoli cells to endocytose and degrade the apoptotic spermatogenic cells and residual bodies (shed cytoplasts) during the maturation phase of spermiogenesis; normally, greater than 50 per cent of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa, and these cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001932 ! abnormal spermiogenesis

[Term]
id: MP:0009852
name: increased Sertoli cell phagocytosis
def: "enhanced phagocytic activity of testicular Sertoli cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009851 ! abnormal Sertoli cell phagocytosis

[Term]
id: MP:0009853
name: decreased Sertoli cell phagocytosis
def: "decreased phagocytic activity of testicular Sertoli cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired Sertoli cell phagocytosis" EXACT []
synonym: "reduced Sertoli cell phagocytosis" EXACT []
is_a: MP:0009851 ! abnormal Sertoli cell phagocytosis

[Term]
id: MP:0009854
name: impaired gastric peristalsis
def: "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed gastric emptying" EXACT []
synonym: "gastroparesis" EXACT []
is_a: MP:0011082 ! abnormal gastrointestinal motility

[Term]
id: MP:0009855
name: obsolete midface retrusion
def: "OBSOLETE. the portion of the face comprising the nasal, maxillary, and zygomatic bones is shortened relative to the calvaria and located posterior to the normal position" [MGI:llw2]
comment: Deprecating and merging with midface hypoplasia, see https://github.com/mgijax/mammalian-phenotype-ontology/issues/3802
is_obsolete: true
replaced_by: MP:0012085

[Term]
id: MP:0009856
name: failure of ejaculation
def: "inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of ejaculation" EXACT []
synonym: "absent ejaculate" EXACT []
synonym: "failure to ejaculate" EXACT []
is_a: MP:0001378 ! abnormal ejaculation

[Term]
id: MP:0009857
name: absent kidney cortex
def: "absence of the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "absent renal cortex" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology

[Term]
id: MP:0009858
name: abnormal cellular extravasation
alt_id: MP:0003629
def: "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
synonym: "abnormal extravasation" EXACT []
synonym: "abnormal immune cell cellular extravasation" EXACT []
synonym: "abnormal leucocyte transmigration" NARROW []
synonym: "abnormal leukocyte transmigration" NARROW []
synonym: "abnormal lymphocyte transmigration" NARROW []
synonym: "abnormal transendothelial leucocyte migration" EXACT []
synonym: "abnormal transendothelial leukocyte migration" EXACT []
is_a: MP:0003156 ! abnormal leukocyte migration

[Term]
id: MP:0009859
name: eye opacity
def: "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "cloudy eyes" EXACT []
synonym: "eyeball opacity" EXACT []
is_a: MP:0002092 ! abnormal eye morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-11-23T12:16:37Z

[Term]
id: MP:0009860
name: nephrosclerosis
def: "hardening of the kidney from overgrowth, infiltration by fibrous connective tissue, and contraction of the interstitial connective tissue; often a result of renovascular diseases or chronic hypertension" [ISBN:0-683-40008-8, MESH:C12.777.419.610]
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-11-23T12:23:19Z

[Term]
id: MP:0009861
name: abnormal pyloric sphincter morphology
def: "any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach" [ISBN:0-683-40008-8]
synonym: "abnormal pyloric valve morphology" EXACT []
xref: MA:0002952
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0010785 ! abnormal stomach pyloric region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-11-23T04:05:01Z

[Term]
id: MP:0009862
name: abnormal aorta elastic tissue morphology
def: "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the aorta wall" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal aorta elastic lamina morphology" EXACT []
synonym: "abnormal aorta elastic laminae morphology" EXACT []
xref: MA:0002859
is_a: MP:0006083 ! abnormal blood vessel elastic tissue morphology
is_a: MP:0009873 ! abnormal aorta tunica media morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T09:40:31Z

[Term]
id: MP:0009863
name: abnormal heart elastic tissue morphology
def: "any structural anomaly of the type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiac elastic tissue morphology" EXACT []
xref: MA:0002858
is_a: MP:0003974 ! abnormal endocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:00:11Z

[Term]
id: MP:0009864
name: abnormal aorta endothelium morphology
def: "any structural anomaly of the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000701
is_a: MP:0009489 ! abnormal blood vessel endothelium morphology
is_a: MP:0009872 ! abnormal aorta tunica intima morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:30:06Z

[Term]
id: MP:0009865
name: abnormal aorta smooth muscle morphology
def: "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000702
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology
is_a: MP:0009873 ! abnormal aorta tunica media morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:33:00Z

[Term]
id: MP:0009866
name: abnormal aorta wall morphology
def: "any structural anomaly of the part of the aorta that encloses the luminal space" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0002901
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:39:12Z

[Term]
id: MP:0009867
name: abnormal ascending aorta morphology
def: "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal aorta ascendens" EXACT []
synonym: "abnormal pars ascendens aortae" EXACT []
xref: Fyler:1431
xref: MA:0002570
is_a: MP:0010468 ! abnormal thoracic aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:41:11Z

[Term]
id: MP:0009868
name: abnormal descending thoracic aorta morphology
def: "any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com]
xref: MA:0002572
is_a: MP:0009869 ! abnormal descending aorta morphology
is_a: MP:0010468 ! abnormal thoracic aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T10:44:36Z

[Term]
id: MP:0009869
name: abnormal descending aorta morphology
def: "any structural anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal aorta descendens" EXACT []
synonym: "abnormal pars descendens aortae" EXACT []
xref: MA:0002571
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T11:10:08Z

[Term]
id: MP:0009870
name: abnormal abdominal aorta morphology
def: "any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs" [http://www.medterms.com]
synonym: "abnormal aorta abdominalis" EXACT []
synonym: "abnormal pars abdominalis aortae" EXACT []
xref: MA:0000474
is_a: MP:0009869 ! abnormal descending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T11:12:21Z

[Term]
id: MP:0009871
name: abnormal aorta tunica adventitia morphology
def: "any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" [ISBN:0-683-40008-8]
synonym: "abnormal aorta adventitia morphology" EXACT []
xref: MA:0002902
is_a: MP:0009866 ! abnormal aorta wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T03:34:40Z

[Term]
id: MP:0009872
name: abnormal aorta tunica intima morphology
def: "any structural anomaly of the innermost layer of the aorta, containing the endothelium and an inner elastic membrane" [ISBN:0-683-40008-8]
xref: MA:0002904
is_a: MP:0009866 ! abnormal aorta wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T03:36:30Z

[Term]
id: MP:0009873
name: abnormal aorta tunica media morphology
def: "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8]
xref: MA:0002903
is_a: MP:0009866 ! abnormal aorta wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-15T03:37:13Z

[Term]
id: MP:0009874
name: abnormal interdigital cell death
def: "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2]
synonym: "abnormal interdigital apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0006280 ! abnormal digit development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:09:39Z

[Term]
id: MP:0009875
name: absent interdigital cell death
def: "no cells undergo programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of any digits" [MGI:llw2]
synonym: "absent interdigital apoptosis" EXACT []
xref: MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"
is_a: MP:0009874 ! abnormal interdigital cell death
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:11:32Z

[Term]
id: MP:0009876
name: increased cellular sensitivity to thiophosphamide
def: "a greater frequency of chromosomal aberrations is found in cells after exposure to the alkylating agent thiophosphamide" [MGI:llw2]
is_a: MP:0008402 ! increased cellular sensitivity to alkylating agents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:15:33Z

[Term]
id: MP:0009877
name: exostosis
def: "a projection of bone, sometimes a benign tumor (osteochondroma), that is capped by cartilage and arises from a bone that develops from cartilage; these usually arise on the joints of bones and are most commonly found on ribs, and also the ankles, knees, shoulders, elbows and hips" [ISBN:0-683-40008-8, MGI:llw2]
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:19:42Z

[Term]
id: MP:0009878
name: decreased susceptibility to bone fracture
def: "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene]
synonym: "resistance to bone fracture" EXACT []
is_a: MP:0004149 ! increased bone strength
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:44:37Z

[Term]
id: MP:0009879
name: abnormal arcus anterior morphology
def: "any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "abnormal anterior arch morphology" EXACT []
synonym: "abnormal arcus anterior atlantis" EXACT []
is_a: MP:0004607 ! abnormal cervical atlas morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T01:52:03Z

[Term]
id: MP:0009880
name: decreased mouth size
def: "abnormally decreased size of the mouth" [MGI:llw2]
synonym: "microstomia" EXACT []
synonym: "reduced mouth size" EXACT []
synonym: "small mouth" EXACT []
is_a: MP:0031503 ! abnormal mouth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T02:01:50Z

[Term]
id: MP:0009881
name: increased mouth size
def: "abnormally increased size of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged mouth" EXACT []
synonym: "large mouth" EXACT []
synonym: "macrostomia" EXACT []
is_a: MP:0031503 ! abnormal mouth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2009-12-17T02:05:21Z

[Term]
id: MP:0009882
name: absent palatal shelf
def: "absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate" [PMID:16680722]
synonym: "absent palatal shelves" EXACT []
synonym: "failure of palatal shelf formation" EXACT []
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T02:48:14Z

[Term]
id: MP:0009883
name: palatal shelf hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, typically resulting in decreased size" [PMID:16680722]
synonym: "hypoplastic palatal shelf" EXACT []
is_a: MP:0031462 ! decreased palatal shelf size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T02:53:02Z

[Term]
id: MP:0009884
name: palatal shelf fusion with tongue or mandible
def: "palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:16:25Z

[Term]
id: MP:0009885
name: abnormal palatal shelf elevation
def: "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
is_a: MP:0009890 ! cleft secondary palate
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:17:08Z

[Term]
id: MP:0009886
name: failure of palatal shelf elevation
def: "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
is_a: MP:0009885 ! abnormal palatal shelf elevation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:17:29Z

[Term]
id: MP:0009887
name: abnormal palatal shelf fusion at midline
def: "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:17:54Z

[Term]
id: MP:0009888
name: palatal shelves fail to meet at midline
def: "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
is_a: MP:0009887 ! abnormal palatal shelf fusion at midline
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:18:59Z

[Term]
id: MP:0009889
name: persistence of medial edge epithelium during palatal shelf fusion
def: "palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam" [PMID:16680722]
is_a: MP:0009887 ! abnormal palatal shelf fusion at midline
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-19T03:35:05Z

[Term]
id: MP:0009890
name: cleft secondary palate
def: "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
synonym: "partial cleft palate" EXACT [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706041/]
is_a: MP:0000111 ! cleft palate
is_a: MP:0013550 ! abnormal secondary palate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T11:04:45Z

[Term]
id: MP:0009891
name: abnormal palate bone morphology
def: "any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal palatal bone morphology" EXACT []
is_a: MP:0002116 ! abnormal craniofacial bone morphology
is_a: MP:0003756 ! abnormal hard palate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T11:38:22Z

[Term]
id: MP:0009892
name: palate bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the palate bone, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic palatal bone" EXACT []
synonym: "hypoplastic palate bone" EXACT []
synonym: "palatal bone hypoplasia" EXACT []
synonym: "palatial bone hypoplasia" EXACT []
is_a: MP:0009891 ! abnormal palate bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:30:11Z

[Term]
id: MP:0009893
name: cleft primary palate
def: "congenital fissure of the tissues normally uniting to form the primary palate; the primary palate will form the premaxillary portion of the maxilla (anterior one-third of the final palate)" [PMID:16680722]
synonym: "cleft primitive palate" EXACT []
is_a: MP:0000111 ! cleft palate
is_a: MP:0013549 ! abnormal primary palate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:33:15Z

[Term]
id: MP:0009894
name: absent hard palate
def: "absence of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003756 ! abnormal hard palate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:33:53Z

[Term]
id: MP:0009895
name: decreased palatine bone horizontal plate size
def: "reduced size of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased horizontal plate size" EXACT []
synonym: "decreased palatal process of palatine bone size" EXACT []
synonym: "decreased palatine palatal process size" EXACT []
synonym: "decreased palatine shelf size" EXACT []
synonym: "small palatine bone horizontal plate" EXACT []
is_a: MP:0004537 ! abnormal palatine bone horizontal plate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:37:15Z

[Term]
id: MP:0009896
name: palatine bone horizontal plate hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the palatine bone horizontal plate, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "horizontal plate hypoplasia" EXACT []
synonym: "hypoplastic horizontal plate" EXACT []
synonym: "hypoplastic palatal process of palatine bone" EXACT []
synonym: "hypoplastic palatine palatal process" EXACT []
synonym: "palatal process of palatine bone hypoplasia" EXACT []
synonym: "palatine palatal process hypoplasia" EXACT []
synonym: "palatine shelf hypoplasia" EXACT []
is_a: MP:0009895 ! decreased palatine bone horizontal plate size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:38:43Z

[Term]
id: MP:0009897
name: decreased maxillary shelf size
def: "reduced size of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased maxillary palatal process size" EXACT []
synonym: "decreased palatal process of maxilla size" EXACT []
synonym: "decreased palatine process size" EXACT []
synonym: "reduced maxillary palatal process size" EXACT []
synonym: "reduced palatal process of maxilla size" EXACT []
synonym: "reduced palatine process size" EXACT []
synonym: "small maxillary shelf" EXACT []
is_a: MP:0004538 ! abnormal maxillary shelf morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:39:08Z

[Term]
id: MP:0009898
name: maxillary shelf hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the maxillary shelf, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypoplastic maxillary palatal process" EXACT []
synonym: "hypoplastic palatal process of maxilla" EXACT []
synonym: "maxillary palatal process hypoplasia" EXACT []
synonym: "palatal process of maxilla hypoplasia" EXACT []
is_a: MP:0009897 ! decreased maxillary shelf size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:39:29Z

[Term]
id: MP:0009899
name: hyoid bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the hyoid bone, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic hyoid bone" EXACT []
synonym: "hypoplastic lingual bone" EXACT []
synonym: "lingual bone hypoplasia" EXACT []
synonym: "tongue bone hypoplasia" EXACT []
is_a: MP:0009912 ! decreased hyoid bone size
is_a: MP:0030386 ! facial bone hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:40:12Z

[Term]
id: MP:0009900
name: vomer bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the vomer bone, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic vomer bone" EXACT []
is_a: MP:0030266 ! small vomer bone
is_a: MP:0030386 ! facial bone hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-20T02:40:44Z

[Term]
id: MP:0009901
name: abnormal frontonasal prominence morphology
def: "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8]
synonym: "abnormal forebrain process" EXACT []
synonym: "abnormal forebrain prominence" EXACT []
synonym: "abnormal frontonasal mass" EXACT []
synonym: "abnormal frontonasal process morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T09:39:03Z

[Term]
id: MP:0009902
name: abnormal lateral nasal prominence morphology
def: "any structural anomaly of the lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it" [ISBN:0-683-40008-8]
synonym: "abnormal lateral nasal fold morphology" EXACT []
synonym: "abnormal lateral nasal process morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T09:44:33Z

[Term]
id: MP:0009903
name: abnormal medial nasal prominence morphology
def: "any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [ISBN:0-683-40008-8]
synonym: "abnormal medial nasal fold morphology" EXACT []
synonym: "abnormal medial nasal process morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T09:49:40Z

[Term]
id: MP:0009904
name: tongue hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the tongue, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic tongue" EXACT []
is_a: MP:0009907 ! decreased tongue size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:06:55Z

[Term]
id: MP:0009905
name: absent tongue
def: "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8]
synonym: "aglossia" EXACT []
synonym: "lingual aplasia" EXACT []
synonym: "missing tongue" EXACT []
synonym: "tongue agenesis" EXACT []
synonym: "tongue aplasia" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:14:16Z

[Term]
id: MP:0009906
name: increased tongue size
def: "greater size the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8]
synonym: "enlarged tongue" EXACT []
synonym: "macroglossia" EXACT []
synonym: "megaglossia" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:16:39Z

[Term]
id: MP:0009907
name: decreased tongue size
alt_id: MP:0006255
def: "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8]
synonym: "microglossia" EXACT []
synonym: "reduced tongue size" EXACT []
synonym: "small tongue" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:20:53Z

[Term]
id: MP:0009908
name: protruding tongue
def: "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [https://orcid.org/0000-0003-3691-0324]
synonym: "tongue protrusion" EXACT []
is_a: MP:0031443 ! abnormal tongue position
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:25:50Z

[Term]
id: MP:0009909
name: bifid tongue
def: "tongue is fully divided by a lengthwise midline cleft" [https://orcid.org/0000-0003-3691-0324, url:https\://medical-dictionary.thefreedictionary.com/bifid+tongue]
synonym: "cleft tongue" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:37:39Z

[Term]
id: MP:0009910
name: bifurcated tongue
def: "tongue is split into two halves at the anterior tip; division does not extend the full length of the tongue; this is normal in some animals such as reptiles" [https://orcid.org/0000-0003-3691-0324]
synonym: "forked tongue" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:51:47Z

[Term]
id: MP:0009911
name: increased hyoid bone size
def: "greater size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8]
synonym: "enlarged hyoid bone" EXACT []
synonym: "enlarged lingual bone" EXACT []
synonym: "enlarged tongue bone" EXACT []
synonym: "increased lingual bone size" EXACT []
synonym: "increased tongue bone size" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:58:00Z

[Term]
id: MP:0009912
name: decreased hyoid bone size
def: "reduced size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8]
synonym: "decreased lingual bone size" EXACT []
synonym: "decreased tongue bone size" EXACT []
synonym: "reduced hyoid bone size" EXACT []
synonym: "reduced lingual bone size" EXACT []
synonym: "reduced tongue bone size" EXACT []
synonym: "small hyoid bone" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T10:58:49Z

[Term]
id: MP:0009913
name: abnormal hyoid bone greater horn morphology
def: "any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8]
synonym: "abnormal hyoid bone greater cornu morphology" EXACT []
synonym: "abnormal hyoid bone superior horn morphology" EXACT []
synonym: "abnormal hyoid bone upper horn morphology" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:03:38Z

[Term]
id: MP:0009914
name: abnormal hyoid bone lesser horn morphology
def: "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8]
synonym: "abnormal hyoid bone lesser cornu morphology" EXACT []
synonym: "abnormal hyoid bone lower horn morphology" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:05:09Z

[Term]
id: MP:0009915
name: absent hyoid bone lesser horns
def: "absence of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8]
synonym: "absent hyoid bone lesser cornu" EXACT []
synonym: "absent hyoid bone lower horns" EXACT []
is_a: MP:0009914 ! abnormal hyoid bone lesser horn morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:05:33Z

[Term]
id: MP:0009916
name: absent hyoid bone greater horns
def: "absence of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8]
synonym: "absent hyoid bone greater cornu" EXACT []
synonym: "absent hyoid bone superior horns" EXACT []
synonym: "absent hyoid bone upper horns" EXACT []
is_a: MP:0009913 ! abnormal hyoid bone greater horn morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:05:57Z

[Term]
id: MP:0009917
name: abnormal hyoid bone body morphology
def: "any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8]
synonym: "abnormal base of hyoid bone" EXACT []
synonym: "abnormal basihyal bone" EXACT []
synonym: "abnormal basihyoid morphology" EXACT []
synonym: "abnormal body of hyoid bone morphology" EXACT []
synonym: "abnormal corpus ossis hyoidei morphology" EXACT []
synonym: "abnormal hyoid bone base" EXACT []
is_a: MP:0003056 ! abnormal hyoid bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:09:04Z

[Term]
id: MP:0009918
name: abnormal stylohyoid ligament morphology
def: "any structural anomaly of the fibrous cord that connects the tip of the styloid process of the temporal bone to the lesser horn of the hyoid bone" [ISBN:0-683-40008-8]
synonym: "abnormal epihyoid ligament morphology" EXACT []
is_a: MP:0005504 ! abnormal ligament morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T11:26:33Z

[Term]
id: MP:0009919
name: abnormal transitional stage T1 B cell morphology
def: "any structural anomaly of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
synonym: "abnormal T1 stage B cell morphology" EXACT []
synonym: "abnormal transitional one stage B lymphocyte morphology" EXACT []
synonym: "abnormal transitional one stage B-cell morphology" EXACT []
synonym: "abnormal transitional one stage B-lymphocyte morphology" EXACT []
xref: CL:0000958
is_a: MP:0008188 ! abnormal transitional stage B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:10:38Z

[Term]
id: MP:0009920
name: abnormal transitional stage T2 B cell morphology
def: "any structural anomaly of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
synonym: "abnormal T2 stage B cell morphology" EXACT []
synonym: "abnormal transitional two stage B lymphocyte morphology" EXACT []
synonym: "abnormal transitional two stage B-cell morphology" EXACT []
synonym: "abnormal transitional two stage B-lymphocyte morphology" EXACT []
xref: CL:0000959
is_a: MP:0008188 ! abnormal transitional stage B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:11:25Z

[Term]
id: MP:0009921
name: abnormal transitional stage T3 B cell morphology
def: "any structural anomaly of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
synonym: "abnormal T3 stage B cell morphology" EXACT []
synonym: "abnormal transitional three stage B lymphocyte morphology" EXACT []
synonym: "abnormal transitional three stage B-cell morphology" EXACT []
synonym: "abnormal transitional three stage B-lymphocyte morphology" EXACT []
xref: CL:0000960
is_a: MP:0008188 ! abnormal transitional stage B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:11:40Z

[Term]
id: MP:0009922
name: increased transitional stage T1 B cell number
def: "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
synonym: "increased T1 stage B cell number" EXACT []
synonym: "increased transitional one stage B lymphocyte number" EXACT []
synonym: "increased transitional one stage B-cell number" EXACT []
synonym: "increased transitional one stage B-lymphocyte number" EXACT []
xref: CL:0000958
is_a: MP:0008189 ! increased transitional stage B cell number
is_a: MP:0009919 ! abnormal transitional stage T1 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:12:21Z

[Term]
id: MP:0009923
name: decreased transitional stage T1 B cell number
def: "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
synonym: "decreased T1 stage B cell number" EXACT []
synonym: "decreased transitional one stage B lymphocyte number" EXACT []
synonym: "decreased transitional one stage B-cell number" EXACT []
synonym: "decreased transitional one stage B-lymphocyte number" EXACT []
synonym: "reduced T1 stage B cell number" EXACT []
synonym: "reduced transitional one stage B lymphocyte number" EXACT []
synonym: "reduced transitional one stage B-cell number" EXACT []
synonym: "reduced transitional one stage B-lymphocyte number" EXACT []
xref: CL:0000958
is_a: MP:0008190 ! decreased transitional stage B cell number
is_a: MP:0009919 ! abnormal transitional stage T1 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:12:48Z

[Term]
id: MP:0009924
name: absent transitional stage T1 B cells
def: "absence of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
synonym: "absent T1 stage B cells" EXACT []
synonym: "absent transitional one stage B lymphocytes" EXACT []
synonym: "absent transitional one stage B-cells" EXACT []
synonym: "absent transitional one stage B-lymphocytes" EXACT []
xref: CL:0000958
is_a: MP:0009923 ! decreased transitional stage T1 B cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:13:06Z

[Term]
id: MP:0009925
name: increased transitional stage T2 B cell number
def: "greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
synonym: "increased T2 stage B cell number" EXACT []
synonym: "increased transitional two stage B lymphocyte number" EXACT []
synonym: "increased transitional two stage B-cell number" EXACT []
synonym: "increased transitional two stage B-lymphocyte number" EXACT []
xref: CL:0000959
is_a: MP:0008189 ! increased transitional stage B cell number
is_a: MP:0009920 ! abnormal transitional stage T2 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:13:49Z

[Term]
id: MP:0009926
name: decreased transitional stage T2 B cell number
def: "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
synonym: "decreased T2 stage B cell number" EXACT []
synonym: "decreased transitional two stage B lymphocyte number" EXACT []
synonym: "decreased transitional two stage B-cell number" EXACT []
synonym: "decreased transitional two stage B-lymphocyte number" EXACT []
synonym: "reduced T2 stage B cell number" EXACT []
synonym: "reduced transitional two stage B lymphocyte number" EXACT []
synonym: "reduced transitional two stage B-cell number" EXACT []
synonym: "reduced transitional two stage B-lymphocyte number" EXACT []
xref: CL:0000959
is_a: MP:0008190 ! decreased transitional stage B cell number
is_a: MP:0009920 ! abnormal transitional stage T2 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:14:05Z

[Term]
id: MP:0009927
name: absent transitional stage T2 B cells
def: "absence of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
synonym: "absent T2 stage B cells" EXACT []
synonym: "absent transitional two stage B lymphocytes" EXACT []
synonym: "absent transitional two stage B-cells" EXACT []
synonym: "absent transitional two stage B-lymphocytes" EXACT []
xref: CL:0000959
is_a: MP:0009926 ! decreased transitional stage T2 B cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:14:20Z

[Term]
id: MP:0009928
name: abnormal pinna hair pigmentation
def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased or increased in hair located behind the ears when compared to control animal pigmentation" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:56:11Z

[Term]
id: MP:0009929
name: meningomyelocele
def: "hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "meningomyelocoele" EXACT []
synonym: "myelocystomeningocele" EXACT []
synonym: "myelocystomeningocoele" EXACT []
synonym: "myelomeningocele" EXACT []
synonym: "myelomeningocoele" EXACT []
xref: Fyler:4309
is_a: MP:0000929 ! open neural tube
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T01:58:56Z

[Term]
id: MP:0009930
name: fuzzy hair
def: "covered with upright, fine, sometimes lightly curled hair" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "fine hair" EXACT []
is_a: MP:0002074 ! abnormal hair texture
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:00:03Z

[Term]
id: MP:0009931
name: abnormal skin appearance
def: "anomaly in the visual aspect of the skin" [MGI:llw2]
subset: Europhenome_Terms
subset: IMPC_Prenatal
subset: Sanger_Terms
is_a: MP:0002060 ! abnormal skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:14:23Z

[Term]
id: MP:0009932
name: skin fibrosis
def: "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "cutaneous fibrosis" EXACT []
is_a: MP:0002060 ! abnormal skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:41:34Z

[Term]
id: MP:0009933
name: abnormal tail hair pigmentation
def: "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:44:35Z

[Term]
id: MP:0009934
name: abnormal hind foot hair pigmentation
def: "an anomaly in the expected color gradient of hair covering the metatarsals and phalanges often differentially expressed in females and males" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:45:24Z

[Term]
id: MP:0009935
name: abnormal Meibomian gland acinus morphology
def: "any structural anomaly of the sac-like structures comprising the sebaceous glands located at the rim of the eyelids and responsible for producing sebum" [https://orcid.org/0000-0003-0431-8641]
synonym: "abnormal meibomian gland acini" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T03:57:53Z

[Term]
id: MP:0009936
name: abnormal dendritic spine morphology
def: "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2]
is_a: MP:0008143 ! abnormal dendrite morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-01-27T04:00:49Z

[Term]
id: MP:0009937
name: abnormal neuron differentiation
alt_id: MP:0006008
def: "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [https://orcid.org/0000-0003-3691-0324]
comment: The definition of the previous ID MP:0006008 [abnormal neurogenesis] specified only the growth or development of neurons; this is not the accepted definition of neurogenesis in GO:0022008 or most dictionary resources; these include all cells of the nervous system including glia. A new term of abnormal neuron differentiation was created that matched the definition and MP:0006008 [abnormal neurogenesis] has been merged into it.
synonym: "abnormal neuronal differentiation" RELATED []
is_a: MP:0002882 ! abnormal neuron morphology
is_a: MP:0003861 ! abnormal nervous system development
is_a: MP:0005076 ! abnormal cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T01:43:56Z

[Term]
id: MP:0009938
name: abnormal hippocampus granule cell morphology
def: "any structural anomaly of the small neurons of the hippocampal granule cell layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hippocampal granule cell morphology" EXACT []
synonym: "abnormal hippocampus granule neuron morphology" EXACT []
xref: CL:0001033
is_a: MP:0008285 ! abnormal hippocampus granule cell layer
is_a: MP:0009939 ! abnormal hippocampus neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T02:23:28Z

[Term]
id: MP:0009939
name: abnormal hippocampus neuron morphology
def: "any structural anomaly of one or more neurons residing in the hippocampal region of the brain" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal hippocampal neuron morphology" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T02:50:11Z

[Term]
id: MP:0009940
name: abnormal hippocampus pyramidal cell morphology
def: "any structural anomaly of a multipolar projection neuron in the hippocampus pyramidal cell layer; pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base; the axons may have local collaterals but also project outside their cortical region" [CL:1001571, https://orcid.org/0000-0003-3691-0324, PMID:21597968]
synonym: "abnormal hippocampus projection neuron morphology" EXACT []
synonym: "abnormal hippocampus pyramidal neuron morphology" EXACT []
is_a: MP:0008284 ! abnormal hippocampus pyramidal cell layer
is_a: MP:0009939 ! abnormal hippocampus neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T02:52:01Z

[Term]
id: MP:0009941
name: abnormal olfactory bulb interneuron morphology
def: "any structural anomaly of the group of neurons residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
is_a: MP:0000819 ! abnormal olfactory bulb morphology
is_a: MP:0000965 ! abnormal sensory neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T03:44:21Z

[Term]
id: MP:0009942
name: abnormal olfactory bulb granule cell morphology
def: "any structural anomaly of the main intrinsic GABAergic neuron in the granule cell layer of the main olfactory bulb; dendrites of these cells receive synaptic input from mitral and tufted cell lateral dendrites in the external plexiform layer, and have synaptic outputs on those dendrites through reciprocal dendrodendritic synapses" [NLX:nifext_123]
synonym: "abnormal olfactory granule neuron morphology" EXACT []
xref: CL:0000626
xref: NLX:nifext_123 "NeuroLex.org"
is_a: MP:0009941 ! abnormal olfactory bulb interneuron morphology
is_a: MP:0009949 ! abnormal olfactory bulb granule cell layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T03:49:07Z

[Term]
id: MP:0009943
name: abnormal olfactory bulb periglomerular cell morphology
def: "any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [NLX:nlx_cell_091202]
synonym: "abnormal olfactory bulb periglomerular neuron morphology" EXACT []
xref: NLX:nlx_cell_091202 "NeuroLex.org"
is_a: MP:0009941 ! abnormal olfactory bulb interneuron morphology
is_a: MP:0009948 ! abnormal olfactory bulb glomerular layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-02T03:49:38Z

[Term]
id: MP:0009944
name: abnormal olfactory lobe morphology
def: "any structural anomaly in the lobe in the anterior part of each cerebral hemisphere that is responsible for olfactory functions" [http://purl.obolibrary.org/obo/UBERON_0005366]
xref: MA:0002413
is_a: MP:0000787 ! abnormal telencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:26:33Z

[Term]
id: MP:0009945
name: abnormal accessory olfactory bulb morphology
def: "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000966
is_a: MP:0009944 ! abnormal olfactory lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:31:49Z

[Term]
id: MP:0009946
name: abnormal olfactory bulb layer morphology
def: "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal olfactory bulb lamina morphology" EXACT []
is_a: MP:0000819 ! abnormal olfactory bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:33:51Z

[Term]
id: MP:0009947
name: abnormal olfactory bulb external plexiform layer morphology
def: "any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96]
synonym: "abnormal olfactory bulb EPL morphology" EXACT []
xref: MA:0000969
xref: NLX:nlx_96 "NeuroLex.org"
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:34:28Z

[Term]
id: MP:0009948
name: abnormal olfactory bulb glomerular layer morphology
def: "any structural anomaly in the most superficial layer of the olfactory bulb that consists of mitral cell dendritic arborizations, olfactory nerve fibers, and periglomerular cells" [http://purl.obolibrary.org/obo/UBERON_0005377]
xref: MA:0000970
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:35:31Z

[Term]
id: MP:0009949
name: abnormal olfactory bulb granule cell layer morphology
def: "any structural anomaly of the olfactory bulb layer consisting primarily of multiple small, round neurons that lack axons" [http://purl.obolibrary.org/obo/UBERON_0005378]
synonym: "abnormal olfactory bulb GC layer morphology" EXACT []
xref: MA:0000971
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:36:16Z

[Term]
id: MP:0009950
name: abnormal olfactory bulb internal plexiform layer morphology
def: "any structural anomaly in the olfactory bulb layer in which axons from mitral cells and axon collaterals of external tufted cells run" [https://www.frontiersin.org/articles/10.3389/fncir.2014.00098/full]
synonym: "abnormal olfactory bulb IPL morphology" EXACT []
xref: MA:0000972
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:36:51Z

[Term]
id: MP:0009951
name: abnormal olfactory bulb mitral cell layer morphology
def: "any structural anomaly in the olfactory bulb layer composed of pyramidal neurons and located between the granule cell and plexiform layers" [http://purl.obolibrary.org/obo/UBERON_0004186]
synonym: "abnormal olfactory bulb MC layer morphology" EXACT []
xref: MA:0000973
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:37:46Z

[Term]
id: MP:0009952
name: abnormal olfactory bulb subventricular zone morphology
def: "any structural anomaly of the region of mitotically active layer of cells surrounding the lateral brain ventricles that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells, that produce neurons that migrate to the olfactory bulb" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal olfactory bulb SEZ morphology" EXACT []
synonym: "abnormal olfactory bulb subependymal layer" EXACT []
synonym: "abnormal olfactory bulb subependymal plate" EXACT []
synonym: "abnormal olfactory bulb subependymal zone morphology" EXACT []
synonym: "abnormal olfactory bulb SVZ morphology" EXACT []
xref: MA:0000974
is_a: MP:0000819 ! abnormal olfactory bulb morphology
is_a: MP:0004275 ! abnormal postnatal subventricular zone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T11:38:44Z

[Term]
id: MP:0009953
name: abnormal olfactory tubercle morphology
def: "any structural anomaly of the region in the ventral telencephalon, prominent in rodents, but present in all mammals, consisting of a laminated cortical part and the cap/hilus region; it is traditionally viewed as part of the olfactory cortex but recognized by some as having a striatal character; according to many authors, the structure of the OT transitions from cortical like to striatal like along the lateral medial axis" [https://orcid.org/0000-0003-3691-0324, NLX:Maryann_Martone]
comment: This structure does not exist in primates.
xref: MA:0000976
is_a: MP:0005267 ! abnormal olfactory cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T12:23:33Z

[Term]
id: MP:0009954
name: abnormal mitral cell morphology
def: "any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8]
synonym: "abnormal mitral neuron morphology" EXACT []
is_a: MP:0009951 ! abnormal olfactory bulb mitral cell layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T12:52:28Z

[Term]
id: MP:0009955
name: abnormal olfactory bulb tufted cell morphology
def: "any structural anomaly of the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala" [NLX:nifext_121]
xref: NLX:nifext_121 "NeuroLex.org"
is_a: MP:0009947 ! abnormal olfactory bulb external plexiform layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T01:46:53Z

[Term]
id: MP:0009956
name: abnormal cerebellar layer morphology
def: "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000201
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T02:19:31Z

[Term]
id: MP:0009957
name: abnormal cerebellum vermis lobule morphology
def: "any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres" [https://orcid.org/0000-0003-3691-0324, PMID:17506688]
is_a: MP:0000864 ! abnormal cerebellum vermis morphology
is_a: MP:0009964 ! abnormal cerebellum lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T02:41:16Z

[Term]
id: MP:0009958
name: absent cerebellar granule cells
def: "absence of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343]
synonym: "absent cerebellar granule neurons" EXACT []
is_a: MP:0008924 ! decreased cerebellar granule cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-04T04:10:40Z

[Term]
id: MP:0009959
name: abnormal cerebellar hemisphere morphology
def: "any structural anomaly of the paired regions of the cerebellum that lie outside and lateral to the central vermis" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000200
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T10:13:02Z

[Term]
id: MP:0009960
name: abnormal cerebellum anterior lobe morphology
def: "any structural anomaly of the region of the cerebellum that is anterior to the primary fissure" [ISBN:0838580343]
synonym: "abnormal cerebellum rostral lobe morphology" EXACT []
synonym: "abnormal paleocerebellum morphology" EXACT []
xref: MA:0000991
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T10:14:07Z

[Term]
id: MP:0009961
name: abnormal flocculonodular lobe morphology
def: "any structural anomaly of the small region of the cerebellum that is posterior to the posteriolateral fissure in humans; it receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance" [http:www.spiritus-temporis.com/cerebellum/anatomy.html, ISBN:0838580343]
synonym: "abnormal archicerebellum morphology" EXACT []
synonym: "abnormal vestibulocerebellum morphology" EXACT []
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T10:15:15Z

[Term]
id: MP:0009962
name: abnormal cerebellum posterior lobe morphology
def: "any structural anomaly of the region of the cerebellum that is posterior to the primary fissure and anterior to the posteriolateral fissure" [ISBN:0838580343]
synonym: "abnormal cerebellum caudal lobe morphology" EXACT []
synonym: "abnormal neocerebellum morphology" EXACT []
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T10:16:51Z

[Term]
id: MP:0009963
name: abnormal cerebellum hemisphere lobule morphology
def: "any structural anomaly of the region of a cerebellar lobule that resides in either of the lateral sections of the cerebellum outside the vermis; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres; distinct species specific differences in hemisphere lobulation occurs among mammals, with greatest complexity in primates" [https://orcid.org/0000-0003-3691-0324, PMID:17506688, PMID:19693030]
is_a: MP:0009959 ! abnormal cerebellar hemisphere morphology
is_a: MP:0009964 ! abnormal cerebellum lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T10:32:12Z

[Term]
id: MP:0009964
name: abnormal cerebellum lobule morphology
def: "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellar folia morphology" EXACT []
synonym: "abnormal cerebellar gyri morphology" EXACT []
is_a: MP:0004097 ! abnormal cerebellar cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T12:37:36Z

[Term]
id: MP:0009965
name: abnormal cerebellum lateral hemisphere morphology
def: "any structural anomaly of the most lateral paired regions of the cerebellum; the lateral zone receives input from the parietal cortex via pontocerebellar mossy fibers regarding the location and position of the body and integrates input signals with indications of muscle activity" [http://www.spiritus-temporis.com/cerebellum/anatomy.html, ISBN:0838580343]
synonym: "abnormal cerebellum lateral zone morphology" EXACT []
synonym: "abnormal cerebrocerebellum morphology" EXACT []
is_a: MP:0009959 ! abnormal cerebellar hemisphere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T12:40:36Z

[Term]
id: MP:0009966
name: abnormal cerebellum intermediate hemisphere morphology
def: "any structural anomaly of the paired regions of the cerebellar hemisphere that lie adjacent to the vermis and are between the vermis and lateral regions of the hemispheres; it receives input from the corticopontocerebellar fibers that originate from the motor cortex, and also receives sensory feedback from the muscles; these signals are integrated by this region, to coordinate muscle activity with motor inputs" [http://www.spiritus-temporis.com/cerebellum/anatomy.html, ISBN:0838580343]
synonym: "abnormal cerebellum paravermis morphology" RELATED []
synonym: "abnormal paravermal cortical zone moprhology" EXACT []
synonym: "abnormal spinocerebellum morphology intermediate part" EXACT []
is_a: MP:0009959 ! abnormal cerebellar hemisphere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-05T12:41:17Z

[Term]
id: MP:0009967
name: abnormal neuron proliferation
def: "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0004811 ! abnormal neuron physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T11:08:37Z

[Term]
id: MP:0009968
name: abnormal cerebellar granule cell precursor proliferation
def: "any anomaly in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009967 ! abnormal neuron proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T11:08:57Z

[Term]
id: MP:0009969
name: abnormal cerebral cortex pyramidal cell morphology
def: "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8]
synonym: "abnormal cerebral cortex projection neuron morphology" EXACT []
synonym: "abnormal cerebral cortex pyramidal neuron morphology" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:32:27Z

[Term]
id: MP:0009970
name: increased hippocampus pyramidal cell number
def: "increased number of the multipolar projection neurons in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased hippocampus projection neuron cell number" EXACT []
synonym: "increased hippocampus pyramidal neuron cell number" EXACT []
is_a: MP:0008947 ! increased neuron number
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:54:08Z

[Term]
id: MP:0009971
name: decreased hippocampus pyramidal cell number
def: "decreased number of the multipolar projection neurons in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hippocampus projection neuron cell number" EXACT []
synonym: "decreased hippocampus pyramidal neuron cell number" EXACT []
synonym: "reduced hippocampus projection neuron cell number" EXACT []
synonym: "reduced hippocampus pyramidal neuron cell number" EXACT []
is_a: MP:0008948 ! decreased neuron number
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:54:38Z

[Term]
id: MP:0009972
name: absent hippocampus pyramidal cells
def: "absence of the multipolar projection neurons in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent hippocampus projection neuron cells" EXACT []
synonym: "absent hippocampus pyramidal neuron cells" EXACT []
is_a: MP:0009971 ! decreased hippocampus pyramidal cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:55:00Z

[Term]
id: MP:0009973
name: increased cerebral cortex pyramidal cell number
def: "increased number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8]
synonym: "increased cerebral cortex projection neuron cell number" EXACT []
synonym: "increased cerebral cortex pyramidal neuron cell number" EXACT []
is_a: MP:0008947 ! increased neuron number
is_a: MP:0009969 ! abnormal cerebral cortex pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:55:26Z

[Term]
id: MP:0009974
name: decreased cerebral cortex pyramidal cell number
def: "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8]
synonym: "decreased cerebral cortex projection neuron cell number" EXACT []
synonym: "decreased cerebral cortex pyramidal neuron cell number" EXACT []
synonym: "reduced cerebral cortex projection neuron cell number" EXACT []
synonym: "reduced cerebral cortex pyramidal neuron cell number" EXACT []
is_a: MP:0008948 ! decreased neuron number
is_a: MP:0009969 ! abnormal cerebral cortex pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:55:54Z

[Term]
id: MP:0009975
name: absent cerebral cortex pyramidal cells
def: "absence of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8]
synonym: "absent cerebral cortex projection neuron cells" EXACT []
synonym: "absent cerebral cortex pyramidal neuron cells" EXACT []
is_a: MP:0009974 ! decreased cerebral cortex pyramidal cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T01:56:17Z

[Term]
id: MP:0009976
name: abnormal cerebellar peduncle morphology
def: "any structural anomaly of any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0002742
is_a: MP:0009978 ! abnormal cerebellum white matter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T03:41:55Z

[Term]
id: MP:0009977
name: abnormal cerebellar granule cell migration
def: "any anomaly in the movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum along radial glia fibers during development of the cerebellar cortex" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006009 ! abnormal neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-08T04:16:50Z

[Term]
id: MP:0009978
name: abnormal cerebellum white matter morphology
def: "any structural anomaly in the region of the cerebellum consisting of myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles" [http://purl.obolibrary.org/obo/UBERON_0002317]
xref: MA:0002430
is_a: MP:0000849 ! abnormal cerebellum morphology
is_a: MP:0008026 ! abnormal brain white matter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T09:46:07Z

[Term]
id: MP:0009979
name: abnormal cerebellum deep nucleus morphology
def: "any structural anomaly of the gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei" [http://www.spiritus-temporis.com/cerebellum/anatomy.html]
synonym: "abnormal cerebellum deep nuclei morphology" EXACT []
xref: MA:0000203
is_a: MP:0000849 ! abnormal cerebellum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T09:46:40Z

[Term]
id: MP:0009980
name: abnormal cerebellum dentate nucleus morphology
def: "any structural anomaly of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellum lateral nucleus morphology" EXACT []
synonym: "abnormal corpus dentatum morphology" EXACT []
synonym: "abnormal dentate cerebellar nucleus morphology" EXACT []
synonym: "abnormal lateral cerebellar nucleus morphology" EXACT []
xref: MA:0001008
is_a: MP:0009979 ! abnormal cerebellum deep nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T10:27:56Z

[Term]
id: MP:0009981
name: abnormal cerebellum emboliform nucleus morphology
def: "any structural anomaly of the small wedge shaped nucleus interposed between the dentate and fastigial nuclei; it receives axons from Purkinje cells of the intermediate area of the cerebral hemispheres and most of its efferent connections travel via the superior cerebellar peduncle" [ISBN:0-683-40008-8]
synonym: "abnormal anterior interposed nucleus morphology" EXACT []
synonym: "abnormal anterior interpositus nucleus morphology" EXACT []
synonym: "abnormal embolus morphology" EXACT []
is_a: MP:0009984 ! abnormal cerebellum interpositus nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T10:29:00Z

[Term]
id: MP:0009982
name: abnormal cerebellum globose nucleus morphology
def: "any structural anomaly of the two or three small masses of gray matter that is located medial to the emboliform nucleus and lateral to the fastigial nucleus; it receives axons from the intermediate area of the cerebellar hemispheres and its afferents exit through the superior cerebellar peduncle; it is recognized in human cerebellum but is not distinguishable in all mammalian species" [ISBN:0-683-40008-8]
synonym: "abnormal posterior interposed nucleus morphology" EXACT []
synonym: "abnormal posterior interpositus nucleus morphology" EXACT []
is_a: MP:0009984 ! abnormal cerebellum interpositus nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T10:29:35Z

[Term]
id: MP:0009983
name: abnormal cerebellum fastigial nucleus morphology
def: "any structural anomaly of the most medial of the cerebellar nuclei; it receives its afferent input from Purkinje cells of the flocculonodular lobe and the vermis, and most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei and to the medullary reticular formation" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellum roof nucleus morphology" EXACT []
synonym: "abnormal cerebellum tectal nucleus morphology" EXACT []
synonym: "abnormal medial cerebellar nucleus morphology" EXACT []
xref: MA:0001009
is_a: MP:0009979 ! abnormal cerebellum deep nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T10:30:15Z

[Term]
id: MP:0009984
name: abnormal cerebellum interpositus nucleus morphology
def: "any structural anomaly of the nucleus composed of the globose and emboliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable" [ISBN:0-683-40008-8]
synonym: "abnormal cerebellum interposed nucleus morphology" EXACT []
is_a: MP:0009979 ! abnormal cerebellum deep nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T11:51:12Z

[Term]
id: MP:0009985
name: abnormal inferior cerebellar peduncle morphology
def: "any structural anomaly of the paired cerebellar peduncles that connects the medulla spinalis and medulla oblongata with the cerebellum, and is composed of juxtarestiform body and restiform body; it carries many types of input and output fibers that are mainly concerned with integrating proprioceptive sensory input with motor vestibular functions such as balance and posture maintenance" [ISBN:0-683-40008-8]
is_a: MP:0009976 ! abnormal cerebellar peduncle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T12:50:42Z

[Term]
id: MP:0009986
name: abnormal middle cerebellar peduncle morphology
def: "any structural anomaly of the largest of the three paired cerebellar peduncles; it is composed mainly of afferent fibers that originate within the pontine nuclei as part of the massive corticopontocerebellar tract, whose fibers descend from the sensory and motor areas of the cerebral neocortex, through the pons and into the cerebellar nuclei and cortex" [ISBN:0-683-40008-8]
is_a: MP:0009976 ! abnormal cerebellar peduncle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T12:50:42Z

[Term]
id: MP:0009987
name: abnormal superior cerebellar peduncle morphology
def: "any structural anomaly of the major output pathway of the cerebellum; most of the efferent fibers originate within the cerebellum dentate nucleus and cerebellum interpositus nuclei, which in turn project to various midbrain structures including the red nucleus, the ventral lateral/ventral anterior nucleus of the thalamus, and the medulla; most of the fibers that pass through this peduncle are involved in pathways important in motor planning" [ISBN:0-683-40008-8]
is_a: MP:0009976 ! abnormal cerebellar peduncle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T12:50:42Z

[Term]
id: MP:0009988
name: abnormal cerebellum vermis lobule I morphology
def: "any structural anomaly of the rostral most of the vermis lobules" [PMID:22083600]
synonym: "abnormal ungula lobule morphology" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009989
name: abnormal cerebellum vermis lobule II morphology
def: "any structural anomaly of the lobule found just caudal to lobule I" [PMID:22083600]
comment: The central lobule (lobules II/III) is a single structure in humans, but it is divided by the posterior superior fissure in rodents.
synonym: "abnormal central lobule morphology anterior part" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009990
name: abnormal cerebellum vermis lobule III morphology
def: "any structural anomaly of the lobule found just caudal to lobule II" [PMID:22083600]
comment: The central lobule (lobules II/III) is a single structure in humans, but it is divided by the posterior superior fissure in rodents.
synonym: "abnormal central lobule morphology posterior part" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009991
name: abnormal cerebellum vermis lobule IV morphology
def: "any structural anomaly of the lobule found just caudal to lobule III" [PMID:22083600]
comment: The culmen lobule (lobules IV/V) is a single structure in humans, but it is divided by the intraculminate fissure in many rodents. In some mouse strains such as SLJ/J, the intraculminate fissure is absent, in some strains such as DBA/2J it is present, and other strains (C57BL/10J and BALB/cJ) exhibit considerable variablility (PMID:1953602).
synonym: "abnormal culmen lobule morphology anterior part" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009992
name: abnormal cerebellum vermis lobule IX morphology
def: "any structural anomaly of the lobule found just caudal to lobule VIII" [PMID:22083600]
synonym: "abnormal uvula lobule morphology" EXACT []
synonym: "abnormal vermal uvula morphology" EXACT []
is_a: MP:0000869 ! abnormal cerebellum posterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009993
name: abnormal cerebellum vermis lobule V morphology
def: "any structural anomaly of the lobule found just caudal to lobule IV" [PMID:22083600]
comment: The culmen lobule (lobules IV/V) is a single structure in humans, but it is divided by the intraculminate fissure in many rodents. In some mouse strains such as SLJ/J, the intraculminate fissure is absent, in some strains such as DBA/2J it is present, and other strains (C57BL/10J and BALB/cJ) exhibit considerable variablility (PMID:1953602).
synonym: "abnormal culmen lobule morphology posterior part" EXACT []
is_a: MP:0000867 ! abnormal cerebellum anterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009994
name: abnormal cerebellum vermis lobule VI morphology
def: "any structural anomaly of the lobule found just caudal to lobule V" [PMID:22083600]
synonym: "abnormal declive lobule morphology" EXACT []
is_a: MP:0000869 ! abnormal cerebellum posterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009995
name: abnormal cerebellum vermis lobule VII morphology
def: "any structural anomaly of the lobule found just caudal to lobule VI" [PMID:22083600]
comment: In rodents, vermis lobule VII is a single structure. In humans, it is cleft by the horizontal fissure into distinct folium (VIIa) and tuber (VIIb) lobules.
synonym: "abnormal folium lobule morphology" NARROW []
synonym: "abnormal tuber lobule morphology" NARROW []
is_a: MP:0000869 ! abnormal cerebellum posterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009996
name: abnormal cerebellum vermis lobule VIII morphology
def: "any structural anomaly of the lobule found just caudal to lobule VII" [PMID:22083600]
synonym: "abnormal cerebellar pyramid morphology" EXACT []
synonym: "abnormal pyramid of vermis morphology" EXACT []
synonym: "abnormal pyramis of cerebellum morphology" EXACT []
synonym: "abnormal vermal pyramis morphology" EXACT []
is_a: MP:0000869 ! abnormal cerebellum posterior vermis morphology
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009997
name: abnormal cerebellum vermis lobule X morphology
def: "any structural anomaly of the caudal most lobule" [PMID:22083600]
synonym: "abnormal nodulus lobule morphology" EXACT []
is_a: MP:0009957 ! abnormal cerebellum vermis lobule morphology
is_a: MP:0009961 ! abnormal flocculonodular lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-11T02:23:06Z

[Term]
id: MP:0009998
name: abnormal cerebellum vermis lobule VIIa morphology
def: "any structural anomaly of the division of the vermis lobule VII that is a short, narrow, concealed band at the posterior extremity of the vermis" [https://www.imaios.com/en/e-anatomy/anatomical-structure/tuber-of-vermis-1553805000?from=2]
comment: In rodents, vermis lobule VII is a single structure. In humans, it is cleft by the horizontal fissure into distinct folium (VIIa) and tuber (VIIb) lobules.
synonym: "abnormal folium lobule morphology" EXACT []
synonym: "abnormal folium of vermis morphology" EXACT []
synonym: "abnormal folium vermis morphology" EXACT []
is_a: MP:0009995 ! abnormal cerebellum vermis lobule VII morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:14:53Z

[Term]
id: MP:0009999
name: abnormal cerebellum vermis lobule VIIb morphology
def: "any structural anomaly in the posterior division of the vermis lobule VII, it is of small size, and laterally spreads out into the large inferior semilunar lobules" [https://www.imaios.com/en/e-anatomy/anatomical-structure/tuber-of-vermis-1553805000?from=2]
comment: In rodents, vermis lobule VII is a single structure. In humans, it is cleft by the horizontal fissure into distinct folium (VIIa) and tuber (VIIb) lobules.
synonym: "abnormal tuber dorsale morphology" EXACT []
synonym: "abnormal tuber lobule morphology" EXACT []
synonym: "abnormal tuber of vermis morphology" EXACT []
synonym: "abnormal tuber valvulae morphology" EXACT []
synonym: "abnormal tuber vermis morphology" EXACT []
is_a: MP:0009995 ! abnormal cerebellum vermis lobule VII morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:16:00Z

[Term]
id: MP:0010000
name: abnormal copula pyramidis morphology
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
synonym: "abnormal COP morphology" EXACT []
is_a: MP:0009963 ! abnormal cerebellum hemisphere lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:19:18Z

[Term]
id: MP:0010001
name: abnormal ansiform lobule morphology
def: "any structural anomaly in the lobule comprising the greater part of the hemisphere of the cerebellum; its superior and inferior surfaces are separated by the horizontal fissure into major parts known as crus I and crus II" [http://purl.obolibrary.org/obo/UBERON_0005348]
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
is_a: MP:0009963 ! abnormal cerebellum hemisphere lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:20:47Z

[Term]
id: MP:0010002
name: abnormal ansiform lobule crus I morphology
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
is_a: MP:0010001 ! abnormal ansiform lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:21:16Z

[Term]
id: MP:0010003
name: abnormal ansiform lobule crus II morphology
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
is_a: MP:0010001 ! abnormal ansiform lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:21:38Z

[Term]
id: MP:0010004
name: abnormal paramedian lobule morphology
def: "any structural anomaly in the anterior portion of the posteroinferior lobule of the cerebellum" [] {comment="UBERON:0005349"}
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
synonym: "abnormal paramedial lobule morphology" EXACT []
synonym: "abormal PML morphology" EXACT []
is_a: MP:0009963 ! abnormal cerebellum hemisphere lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:22:59Z

[Term]
id: MP:0010005
name: abnormal lobule simplex morphology
comment: This is a structure present in rodents and is not present in humans. The cerebellum hemisphere structure and lobulation is dramatically different between these species.
synonym: "abnormal LS morphology" EXACT []
synonym: "abnormal simple lobule morphology" EXACT []
is_a: MP:0009963 ! abnormal cerebellum hemisphere lobule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:24:12Z

[Term]
id: MP:0010006
name: abnormal flocculus morphology
def: "any structural anomaly of the small region of the cerebellum that receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
comment: This is a structure present in both rodents and humans, but the location and morphology is dramatically different between these species.
is_a: MP:0009959 ! abnormal cerebellar hemisphere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:28:41Z

[Term]
id: MP:0010007
name: abnormal paraflocculus morphology
def: "any structural anomaly in the lateral part of the flocculus of the cerebellum that receives and integrates multi-modal sensory inputs" [https://api.research-repository.uwa.edu.au/ws/portalfiles/portal/13016536/accepted_manuscript_VOGLER_hearing_research.pdf, https://en.wiktionary.org/wiki/paraflocculus]
comment: This is a structure present in both rodents and humans, but the location and morphology is dramatically different between these species.
is_a: MP:0009959 ! abnormal cerebellar hemisphere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-12T11:29:15Z

[Term]
id: MP:0010008
name: abnormal Purkinje cell migration
def: "any anomaly in the movement of immature Purkinje cells from the ventricular zone of the fourth ventricle along radial glial cells to the forming Purkinje cell layer during development of the cerebellar cortex" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal Purkinje neuron migration" EXACT []
is_a: MP:0006009 ! abnormal neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-15T11:34:30Z

[Term]
id: MP:0010009
name: abnormal piriform cortex morphology
def: "any structural anomaly of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions" [PMID:17714095]
synonym: "abnormal lateral olfactory gyrus morphology" RELATED []
synonym: "abnormal piriform area morphology" EXACT []
synonym: "abnormal primary olfactory cortex morphology" EXACT []
synonym: "abnormal pyriform cortex morphology" EXACT []
xref: MA:0000978
is_a: MP:0005267 ! abnormal olfactory cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T12:49:07Z

[Term]
id: MP:0010010
name: abnormal islands of Calleja morphology
def: "any structural anomaly of the seven small groups of granule cells in the polymorph layer of the olfactory tubercle and one large group, the insula magna, which lies along the border between septum, nucleus accumbens and nucleus of the diagonal band" [PMID:80412]
comment: The islands of Calleja are located within the olfactory tubercle in most species; however, in primates these islands are located within the nucleus accumbens, since the olfactory tubercle is absent or extremely rudimentary in the brains of primates. We have currently placed this term as a child of both abnormal nucleus accumbens morphology and abnormal olfactory tubercle morphology but we may need to reconsider this placement.
xref: MA:0000977
is_a: MP:0004080 ! abnormal nucleus accumbens morphology
is_a: MP:0009953 ! abnormal olfactory tubercle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T02:00:17Z

[Term]
id: MP:0010011
name: ectopic hippocampus pyramidal cells
def: "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [https://orcid.org/0000-0003-3691-0324]
synonym: "ectopic hippocampus pyramidal neurons" EXACT []
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T02:38:08Z

[Term]
id: MP:0010012
name: ectopic cerebral cortex pyramidal cells
def: "the cerebral cortex pyramidal cell body resides in places other than the pyramidal cell layer of the cerebral cortex" [https://orcid.org/0000-0003-3691-0324]
synonym: "ectopic cerebral cortex pyramidal neurons" EXACT []
is_a: MP:0009969 ! abnormal cerebral cortex pyramidal cell morphology
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T02:39:06Z

[Term]
id: MP:0010013
name: cerebral cortex pyramidal cell degeneration
def: "a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the cerebral cortex" [https://orcid.org/0000-0003-3691-0324]
synonym: "cerebral cortex pyramidal neuron degeneration" EXACT []
is_a: MP:0009969 ! abnormal cerebral cortex pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T02:45:00Z

[Term]
id: MP:0010014
name: hippocampus pyramidal cell degeneration
def: "a retrogressive impairment or destruction of a multipolar projection neuron in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
synonym: "hippocampal pyramidal cell degeneration" EXACT []
synonym: "hippocampus pyramidal neuron degeneration" EXACT []
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T02:46:16Z

[Term]
id: MP:0010015
name: abnormal cuticular plate morphology
def: "any structural anomaly of the firm laminar network of actin filaments in the organ of Corti to which the apical ends of the cochlear hair cells attach and through which their stereocilia project" [PMID:12324381]
is_a: MP:0000042 ! abnormal organ of Corti morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-16T04:25:17Z

[Term]
id: MP:0010016
name: variable depigmentation
alt_id: MP:0002198
def: "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2]
synonym: "vitiligo" EXACT []
synonym: "white skin spotting" EXACT []
is_a: MP:0002095 ! abnormal skin pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:11:22Z

[Term]
id: MP:0010017
name: visceral vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000255 ! blood vessel congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:19:25Z

[Term]
id: MP:0010018
name: pulmonary vascular congestion
alt_id: MP:0010888
def: "obstruction of the normal flux of blood within the blood vessel network of the lung resulting in engorgement of pulmonary vessels; frequently precedes pulmonary edema" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "congested lung vasculature" EXACT []
synonym: "lung vascular congestion" EXACT []
synonym: "pulmonary congestion" EXACT []
synonym: "PVC" EXACT []
is_a: MP:0004007 ! abnormal lung vasculature morphology
is_a: MP:0010017 ! visceral vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:20:42Z

[Term]
id: MP:0010019
name: liver vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the liver" [https://orcid.org/0000-0002-6490-7723]
synonym: "congested liver vasculature" EXACT []
synonym: "hepatic vascular congestion" EXACT []
is_a: MP:0009820 ! abnormal liver vasculature morphology
is_a: MP:0010017 ! visceral vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:22:02Z

[Term]
id: MP:0010020
name: spleen vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the spleen" [https://orcid.org/0000-0002-6490-7723]
synonym: "congested spleen vasculature" EXACT []
synonym: "splenic vascular congestion" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology
is_a: MP:0010017 ! visceral vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:28:26Z

[Term]
id: MP:0010021
name: heart vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "cardiac vascular congestion" EXACT []
synonym: "congested vasculature of the heart" EXACT []
synonym: "heart congestion" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0010017 ! visceral vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:30:24Z

[Term]
id: MP:0010022
name: brain vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "congested brain vasculature" EXACT []
is_a: MP:0000255 ! blood vessel congestion
is_a: MP:0004950 ! abnormal brain vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:36:18Z

[Term]
id: MP:0010023
name: cerebral vascular congestion
def: "obstruction of the normal flux of blood within the blood vessel network of the cerebrum" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology
is_a: MP:0010022 ! brain vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-17T03:53:44Z

[Term]
id: MP:0010024
name: increased total body fat amount
alt_id: MP:0005453
def: "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "increased adipose tissue amount" EXACT []
synonym: "increased adiposity" EXACT []
synonym: "increased body fat" RELATED []
synonym: "increased total body adipose tissue amount" EXACT []
is_a: MP:0005452 ! abnormal adipose tissue amount
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-22T12:58:49Z

[Term]
id: MP:0010025
name: decreased total body fat amount
alt_id: MP:0005454
def: "less than the normal total amount of connective tissue composed of fat cells within the entire body" [https://orcid.org/0000-0003-3691-0324]
subset: Europhenome_Terms
subset: IMPC
subset: Sanger_Terms
synonym: "decreased adipose tissue amount" EXACT []
synonym: "decreased adiposity" EXACT []
synonym: "decreased body fat" RELATED []
synonym: "decreased total adipose tissue amount" EXACT []
synonym: "reduced adipose tissue amount" EXACT []
synonym: "reduced total adipose tissue amount" EXACT []
synonym: "reduced total body fat amount" EXACT []
is_a: MP:0005452 ! abnormal adipose tissue amount
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-22T01:41:16Z

[Term]
id: MP:0010026
name: decreased liver cholesterol level
def: "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hepatic cholesterol level" EXACT []
synonym: "reduced hepatic cholesterol level" RELATED []
synonym: "reduced liver cholesterol level" EXACT []
is_a: MP:0003983 ! decreased cholesterol level
is_a: MP:0012776 ! abnormal liver cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-24T03:00:30Z

[Term]
id: MP:0010027
name: increased liver cholesterol level
def: "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased hepatic cholesterol level" EXACT []
is_a: MP:0003982 ! increased cholesterol level
is_a: MP:0012776 ! abnormal liver cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-24T03:00:50Z

[Term]
id: MP:0010028
name: aciduria
def: "excretion of urine with an acid pH" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-02-24T03:07:00Z

[Term]
id: MP:0010029
name: abnormal basicranium morphology
alt_id: MP:0005273
def: "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8]
synonym: "abnormal base of skull morphology" EXACT []
synonym: "abnormal basis cranii morphology" EXACT []
synonym: "abnormal cranial base morphology" EXACT []
synonym: "basicranium dysplasia" NARROW []
synonym: "cranial base dysplasia" NARROW []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2010-03-01T01:05:40Z

[Term]
id: MP:0010030
name: abnormal orbit morphology
alt_id: MP:0005246
def: "any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones" [ISBN:0-683-40008-8]
comment: In human, the orbit is comprised of parts of seven cranial bones (frontal, maxillary, sphenoid, lacrimal, zygomatic, ethmoidal and palatine). In mouse, the orbit is comprised of parts of eight cranial bones (maxilla, lacrimal, zygomatic, frontal, temporal, sphenoid, ethmoid, and palatine).
synonym: "abnormal eye socket morphology" EXACT []
synonym: "abnormal orbit" EXACT []
synonym: "orbit abnormalities" EXACT []
xref: MA:0002482
is_a: MP:0000438 ! abnormal cranium morphology
is_a: MP:0002092 ! abnormal eye morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-01T01:21:37Z

[Term]
id: MP:0010031
name: abnormal cranium size
def: "deviation from the average range of cranium size compared to normal" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skull size" RELATED []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-01T01:35:41Z

[Term]
id: MP:0010032
name: obsolete meiotic drive
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0020957
created_by: csmith
creation_date: 2010-03-01T03:23:56Z

[Term]
id: MP:0010033
name: paraphimosis
def: "inability of the penis to retract back into the prepuce/foreskin; entrapment of a retracted foreskin behind the coronal sulcus" [MGI:mberry]
is_a: MP:0005187 ! abnormal penis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-02T03:34:34Z

[Term]
id: MP:0010034
name: abnormal erythrocyte clearance
def: "any anomaly in the selective elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003656 ! abnormal erythrocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-02T03:44:19Z

[Term]
id: MP:0010035
name: increased erythrocyte clearance
def: "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010034 ! abnormal erythrocyte clearance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-02T03:51:36Z

[Term]
id: MP:0010036
name: decreased erythrocyte clearance
def: "decreased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced erythrocyte clearance" EXACT []
is_a: MP:0010034 ! abnormal erythrocyte clearance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-02T03:52:09Z

[Term]
id: MP:0010037
name: ectopic melanocytes
def: "pigment producing cells are not located in the normal or expected position" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002877 ! abnormal melanocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T10:09:29Z

[Term]
id: MP:0010038
name: abnormal placenta physiology
def: "any functional anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T10:33:47Z

[Term]
id: MP:0010039
name: abnormal trophoblast giant cell proliferation
def: "abnormality in the expansion rate of the trophoblast giant cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0010038 ! abnormal placenta physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T10:37:42Z

[Term]
id: MP:0010040
name: abnormal oval cell morphology
def: "any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
synonym: "abnormal adult liver progenitor cell morphology" EXACT []
synonym: "abnormal hepatic oval cell morphology" EXACT []
synonym: "abnormal hepatic oval stem cell morphology" EXACT []
synonym: "abnormal LPC morphology" EXACT []
xref: CL:1000036
is_a: MP:0002138 ! abnormal hepatobiliary system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T10:47:13Z

[Term]
id: MP:0010041
name: absent oval cells
def: "absence of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
synonym: "aabsent LPCs" EXACT []
synonym: "absent adult liver progenitor cells" EXACT []
synonym: "absent hepatic oval cells" EXACT []
xref: CL:1000036
is_a: MP:0010040 ! abnormal oval cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T10:57:11Z

[Term]
id: MP:0010042
name: abnormal oval cell physiology
def: "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
synonym: "abnormal adult liver progenitor cell physiology" EXACT []
synonym: "abnormal hepatic oval cell physiology" EXACT []
synonym: "abnormal LPC physiology" EXACT []
xref: CL:1000036
is_a: MP:0000609 ! abnormal liver physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T11:01:11Z

[Term]
id: MP:0010043
name: abnormal frontonasal suture morphology
def: "any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones" [ISBN:0-683-40008-8]
is_a: MP:0030229 ! abnormal craniofacial suture morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T11:44:24Z

[Term]
id: MP:0010044
name: abnormal omental fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8]
synonym: "abnormal omental fat depot morphology" EXACT []
is_a: MP:0000010 ! abnormal abdominal fat pad morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T11:58:15Z

[Term]
id: MP:0010045
name: increased omental fat pad weight
def: "greater than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8]
synonym: "increased omental fat depot weight" EXACT []
is_a: MP:0010044 ! abnormal omental fat pad morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T12:04:27Z

[Term]
id: MP:0010046
name: decreased omental fat pad weight
def: "less than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8]
synonym: "decreased omental fat depot weight" EXACT []
synonym: "reduced omental fat depot weight" EXACT []
is_a: MP:0010044 ! abnormal omental fat pad morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T12:04:44Z

[Term]
id: MP:0010047
name: axonal spheroids
def: "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421, PMID:31628183, PMID:32330411]
synonym: "axonal beading" EXACT []
synonym: "axonal beads" EXACT []
synonym: "beaded axons" EXACT []
is_a: MP:0005405 ! axon degeneration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T12:26:56Z

[Term]
id: MP:0010048
name: abnormal primitive streak regression
def: "any anomaly in the process by which the primitive streak disappears during gastrulation, when the node moves back to a posterior position" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002231 ! abnormal primitive streak morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T12:44:07Z

[Term]
id: MP:0010050
name: hypermyelination
def: "increased myelin formation in a myelin sheath over all or part of an axon or fiber tract, usually resulting in a thicker myelin sheath" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased myelination" EXACT []
is_a: MP:0000920 ! abnormal myelination
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T01:21:00Z

[Term]
id: MP:0010052
name: increased grip strength
def: "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0001515 ! abnormal grip strength
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T01:33:45Z

[Term]
id: MP:0010053
name: decreased grip strength
def: "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced grip strength" EXACT []
is_a: MP:0001515 ! abnormal grip strength
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T01:34:19Z

[Term]
id: MP:0010054
name: increased hepatoblastoma incidence
def: "greater than the expected number of a malignant neoplasm occurring primarily in the liver and composed of tissue resembling embryonic or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "hepatic blastoma" RELATED []
synonym: "hepatoblastoma" RELATED []
synonym: "liver blastoma" RELATED []
is_a: MP:0008019 ! increased liver tumor incidence
is_a: MP:0008021 ! increased blastoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T03:22:41Z

[Term]
id: MP:0010055
name: abnormal sensory neuron physiology
def: "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8]
is_a: MP:0004811 ! abnormal neuron physiology
is_a: MP:0005423 ! abnormal somatic nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-03T04:06:33Z

[Term]
id: MP:0010056
name: ectopic skeletal muscle
def: "skeletal muscle is located in a position not normally occupied by this tissue type" [https://orcid.org/0000-0003-3691-0324]
synonym: "heterotopic skeletal muscle" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-04T02:09:05Z

[Term]
id: MP:0010057
name: abnormal olfactory bulb outer nerve layer morphology
def: "any structural anomaly of the outermost layer of the olfactory bulb; consists primarily of olfactory afferent axons and ensheathing glia" [PMID:12533617]
synonym: "abnormal olfactory bulb ONL morphology" EXACT []
is_a: MP:0009946 ! abnormal olfactory bulb layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-05T12:10:15Z

[Term]
id: MP:0010058
name: enlarged olfactory bulb
def: "increased size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased olfactory bulb size" EXACT []
is_a: MP:0000819 ! abnormal olfactory bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-05T01:38:37Z

[Term]
id: MP:0010059
name: olfactory bulb hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the olfactory bulb, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypoplastic olfactory bulb" EXACT []
is_a: MP:0002741 ! small olfactory bulb
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-05T01:45:03Z

[Term]
id: MP:0010060
name: abnormal creatine level
def: "anomaly in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal creatin concentration" NARROW []
synonym: "abnormal creatine concentration" EXACT []
synonym: "abnormal phosphocreatine concentration" NARROW []
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T11:21:46Z

[Term]
id: MP:0010061
name: increased creatine level
def: "increase in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased creatin concentration" EXACT []
synonym: "increased creatine concentration" NARROW []
synonym: "increased phosphocreatine concentration" NARROW []
is_a: MP:0010060 ! abnormal creatine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T12:06:31Z

[Term]
id: MP:0010062
name: decreased creatine level
def: "reduction in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased creatin concentration" EXACT []
synonym: "decreased creatine concentration" NARROW []
synonym: "decreased phosphocreatine concentration" NARROW []
synonym: "reduced creatin concentration" EXACT []
synonym: "reduced creatine level" EXACT []
synonym: "reduced phosphocreatine concentration" NARROW []
is_a: MP:0010060 ! abnormal creatine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T12:06:51Z

[Term]
id: MP:0010063
name: abnormal circulating creatine level
def: "anomaly in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circulating creatin concentration" EXACT []
synonym: "abnormal circulating creatine concentration" EXACT []
is_a: MP:0010060 ! abnormal creatine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T12:07:10Z

[Term]
id: MP:0010064
name: increased circulating creatine level
def: "increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased circulating creatin concentration" EXACT []
synonym: "increased circulating creatine concentration" EXACT []
is_a: MP:0010061 ! increased creatine level
is_a: MP:0010063 ! abnormal circulating creatine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T12:07:29Z

[Term]
id: MP:0010065
name: decreased circulating creatine level
def: "reduction in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased circulating creatin concentration" EXACT []
synonym: "decreased circulating creatine concentration" EXACT []
synonym: "reduced circulating creatin concentration" EXACT []
synonym: "reduced circulating creatine concentration" EXACT []
is_a: MP:0010062 ! decreased creatine level
is_a: MP:0010063 ! abnormal circulating creatine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T12:07:58Z

[Term]
id: MP:0010066
name: abnormal red blood cell distribution width
def: "an anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism" [https://orcid.org/0000-0003-3691-0324, NCI:C64800]
synonym: "abnormal erythrocyte distribution width" EXACT []
synonym: "abnormal RDW" EXACT []
synonym: "abnormal red blood cell size variability" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T03:18:27Z

[Term]
id: MP:0010067
name: increased red blood cell distribution width
def: "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [https://orcid.org/0000-0003-3691-0324, NCI:C64800]
subset: IMPC
subset: Sanger_Terms
synonym: "high RDW" EXACT []
synonym: "high red blood cell distribution width" EXACT []
synonym: "increased erythrocyte distribution width" EXACT []
synonym: "increased red blood cell size variability" EXACT []
is_a: MP:0010066 ! abnormal red blood cell distribution width
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T03:40:51Z

[Term]
id: MP:0010068
name: decreased red blood cell distribution width
def: "lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [https://orcid.org/0000-0003-3691-0324, NCI:C64800]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased erythrocyte distribution width" EXACT []
synonym: "decreased red blood cell size variability" EXACT []
synonym: "low RDW" EXACT []
synonym: "low red blood cell distribution width" EXACT []
synonym: "reduced erythrocyte distribution width" EXACT []
synonym: "reduced RDW" EXACT []
synonym: "reduced red blood cell distribution width" EXACT []
synonym: "reduced red blood cell size variability" EXACT []
is_a: MP:0010066 ! abnormal red blood cell distribution width
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-09T03:40:51Z

[Term]
id: MP:0010069
name: increased serotonin level
def: "increase in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8]
synonym: "increased 5-HT level" EXACT []
synonym: "increased 5-hydroxytryptamine level" EXACT []
synonym: "increased enteramine level" EXACT []
synonym: "increased hippophaine level" RELATED []
synonym: "increased hydroxytryptamine level" EXACT []
synonym: "increased serotonin concentration" RELATED []
is_a: MP:0005322 ! abnormal serotonin level
is_a: MP:0014454 ! increased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T02:44:09Z

[Term]
id: MP:0010070
name: decreased serotonin level
def: "reduction in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8]
synonym: "decreased 5-HT level" EXACT []
synonym: "decreased 5-hydroxytryptamine level" EXACT []
synonym: "decreased enteramine level" EXACT []
synonym: "decreased hippophaine level" EXACT []
synonym: "decreased hydroxytryptamine level" EXACT []
synonym: "decreased serotonin concentration" RELATED []
synonym: "reduced serotonin concentration" EXACT []
synonym: "reduced serotonin level" EXACT []
is_a: MP:0005322 ! abnormal serotonin level
is_a: MP:0014455 ! decreased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T02:44:38Z

[Term]
id: MP:0010071
name: abnormal pruritus
def: "anomaly in the normal absence or presence of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8]
synonym: "abnormal itch reaction" EXACT []
synonym: "abnormal itchiness response" EXACT []
is_a: MP:0005501 ! abnormal skin physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T02:58:04Z

[Term]
id: MP:0010072
name: increased pruritus
def: "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8]
synonym: "increased itch reponse" EXACT []
synonym: "increased itchiness" EXACT []
is_a: MP:0010071 ! abnormal pruritus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:29:34Z

[Term]
id: MP:0010073
name: decreased pruritus
def: "absence or decreased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8]
synonym: "decreased itch response" EXACT []
synonym: "decreased itchiness" EXACT []
is_a: MP:0010071 ! abnormal pruritus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:32:39Z

[Term]
id: MP:0010074
name: stomatocytosis
def: "deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape" [ISBN:0-683-40008-8]
synonym: "hydrocytosis" EXACT []
synonym: "increased fish mouth cell number" EXACT []
synonym: "increased mouth-shaped erythrocyte number" EXACT []
synonym: "increased stomatocyte number" RELATED []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:38:16Z

[Term]
id: MP:0010075
name: abnormal circulating phytosterol level
def: "anomaly in the amount of phytosterols in the blood; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circulating phytosterol concentration" EXACT []
synonym: "abnormal circulating plant sterol concentration" EXACT []
synonym: "abnormal circulating plant sterol level" EXACT []
is_a: MP:0003949 ! abnormal circulating lipid level
is_a: MP:0010076 ! abnormal phytosterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:51:43Z

[Term]
id: MP:0010076
name: abnormal phytosterol level
def: "anomaly in the amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols;commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [ISBN:0-683-40008-8]
synonym: "abnormal plant sterol concentration" EXACT []
synonym: "abnormal plant sterol level" EXACT []
is_a: MP:0012224 ! abnormal sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:53:35Z

[Term]
id: MP:0010077
name: increased phytosterol level
def: "increased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [ISBN:0-683-40008-8]
synonym: "increased plant sterol concentration" EXACT []
synonym: "increased plant sterol level" EXACT []
synonym: "phytosterolemia" EXACT []
synonym: "sitosterolemia" EXACT []
is_a: MP:0010076 ! abnormal phytosterol level
is_a: MP:0012226 ! increased sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T03:55:49Z

[Term]
id: MP:0010078
name: increased circulating phytosterol level
def: "increase in the amount of phytosterols in the blood; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased circulating phytosterol concentration" EXACT []
synonym: "increased circulating plant sterol concentration" EXACT []
synonym: "increased circulating plant sterol level" EXACT []
is_a: MP:0010075 ! abnormal circulating phytosterol level
is_a: MP:0010077 ! increased phytosterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-12T04:02:19Z

[Term]
id: MP:0010079
name: increased osteochondroma incidence
def: "greater than the expected number of a benign cartilagenous neoplasm that consists of a pedicle of normal bone capped by a region of proliferating cartilage cells, occurring in a specific population in a given time period; osteochondroma is most often associated with one or more of the long bones" [ISBN:0-683-40008-8]
synonym: "osteochondroma" RELATED []
is_a: MP:0010280 ! increased skeletal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-19T02:34:32Z

[Term]
id: MP:0010080
name: abnormal hepatocyte physiology
def: "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000609 ! abnormal liver physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-23T01:37:46Z

[Term]
id: MP:0010081
name: posterior microphthalmia
def: "reduced average size of the back of the eye" [MGI:llw2]
is_a: MP:0001297 ! microphthalmia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-26T03:59:01Z

[Term]
id: MP:0010082
name: sternebra fusion
def: "appearance of one or more sternebrae as a single structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused sternebrae" EXACT []
synonym: "sternebrae fusion" EXACT []
synonym: "sternebral fusion" EXACT []
is_a: MP:0004322 ! abnormal sternebra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-26T04:04:26Z

[Term]
id: MP:0010084
name: abnormal long lived plasma cell morphology
def: "any structural anomaly of a fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive; the majority of these cells of this type reside in the bone marrow" [CL:0000974]
is_a: MP:0002439 ! abnormal plasma cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T10:53:46Z

[Term]
id: MP:0010085
name: abnormal short lived plasma cell morphology
def: "any structural anomaly of a fully differentiated plasma cell that lives for months, not years" [CL:0000975]
is_a: MP:0002439 ! abnormal plasma cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T10:56:46Z

[Term]
id: MP:0010086
name: abnormal circulating fructosamine level
def: "any anomaly in the concentration in the blood of total non enzymatic glycated proteins in the blood" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circulating glycated serum protein level" EXACT []
synonym: "abnormal circulating GSP level" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T11:03:21Z

[Term]
id: MP:0010087
name: increased circulating fructosamine level
def: "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased circulating glycated serum protein level" EXACT []
synonym: "increased circulating GSP level" EXACT []
is_a: MP:0010086 ! abnormal circulating fructosamine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T11:27:53Z

[Term]
id: MP:0010088
name: decreased circulating fructosamine level
def: "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating glycated serum protein level" EXACT []
synonym: "decreased circulating GSP level" EXACT []
synonym: "reduced circulating fructosamine level" EXACT []
synonym: "reduced circulating glycated serum protein level" EXACT []
synonym: "reduced circulating GSP level" EXACT []
is_a: MP:0010086 ! abnormal circulating fructosamine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T11:30:42Z

[Term]
id: MP:0010089
name: abnormal circulating creatine kinase level
def: "any anomaly in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0003-3691-0324]
comment: There is ambiguity in the literature regarding the terms creatinine kinase and creatine kinase. Most resources insist that creatine kinase is correct. See PMID:17174558 and PMID:14624200 not to mention Wikipedia.  Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. The small amount of CK that is normally in the blood comes primarily from skeletal muscles.
synonym: "abnormal circulating CK level" EXACT []
synonym: "abnormal circulating CPK level" EXACT []
synonym: "abnormal circulating creatine phosphokinase level" EXACT []
synonym: "abnormal circulating creatinine kinase level" EXACT []
synonym: "abnormal circulating phospho-creatine kinase level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
is_a: MP:0020279 ! abnormal creatine kinase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T12:56:17Z

[Term]
id: MP:0010090
name: increased circulating creatine kinase level
def: "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0003-3691-0324]
comment: There is ambiguity in the literature regarding the terms creatinine kinase and creatine kinase. Most resources insist that creatine kinase is correct. See PMID:17174558 and PMID:14624200 not to mention Wikipedia. Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. The small amount of CK that is normally in the blood comes primarily from skeletal muscles.
subset: IMPC
subset: Sanger_Terms
synonym: "elevated circulating CK level" EXACT []
synonym: "elevated circulating CPK level" EXACT []
synonym: "elevated circulating creatine kinase level" EXACT []
synonym: "elevated circulating creatine phosphokinase level" EXACT []
synonym: "elevated circulating creatinine kinase level" EXACT []
synonym: "elevated circulating phospho-creatine kinase level" EXACT []
synonym: "increased circulating CK level" EXACT []
synonym: "increased circulating CPK level" EXACT []
synonym: "increased circulating creatine phosphokinase level" EXACT []
synonym: "increased circulating creatinine kinase level" EXACT []
synonym: "increased circulating phospho-creatine kinase level" EXACT []
is_a: MP:0010089 ! abnormal circulating creatine kinase level
is_a: MP:0014450 ! increased circulating enzyme level
is_a: MP:0020280 ! increased creatine kinase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T12:56:45Z

[Term]
id: MP:0010091
name: decreased circulating creatine kinase level
def: "a reduction in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0003-3691-0324]
comment: There is ambiguity in the literature regarding the terms creatinine kinase and creatine kinase. Most resources insist that creatine kinase is correct. See PMID:17174558 and PMID:14624200 not to mention Wikipedia. Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. The small amount of CK that is normally in the blood comes primarily from skeletal muscles.
subset: IMPC
subset: Sanger_Terms
synonym: "decreased circulating CK level" EXACT []
synonym: "decreased circulating CPK level" EXACT []
synonym: "decreased circulating creatine phosphokinase level" EXACT []
synonym: "decreased circulating creatinine kinase level" EXACT []
synonym: "decreased circulating phospho-creatine kinase level" EXACT []
synonym: "reduced circulating CK level" EXACT []
synonym: "reduced circulating CPK level" EXACT []
synonym: "reduced circulating creatine kinase level" EXACT []
synonym: "reduced circulating creatine phosphokinase level" EXACT []
synonym: "reduced circulating creatinine kinase level" EXACT []
synonym: "reduced circulating phospho-creatine kinase level" EXACT []
is_a: MP:0010089 ! abnormal circulating creatine kinase level
is_a: MP:0014451 ! decreased circulating enzyme level
is_a: MP:0020281 ! decreased creatine kinase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T12:56:51Z

[Term]
id: MP:0010092
name: increased circulating magnesium level
def: "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "elevated circulating magnesium level" EXACT []
synonym: "hypermagnesaemia" EXACT []
synonym: "hypermagnesemia" EXACT []
is_a: MP:0001771 ! abnormal circulating magnesium level
is_a: MP:0031659 ! increased magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T01:33:11Z

[Term]
id: MP:0010093
name: decreased circulating magnesium level
def: "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "hypomagnesaemia" EXACT []
synonym: "hypomagnesemia" EXACT []
synonym: "reduced circulating magnesium level" EXACT []
is_a: MP:0001771 ! abnormal circulating magnesium level
is_a: MP:0031658 ! decreased magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T01:33:34Z

[Term]
id: MP:0010094
name: abnormal chromosome stability
def: "anomaly in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
is_a: MP:0014241 ! abnormal intracellular organelle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T01:43:05Z

[Term]
id: MP:0010095
name: increased chromosomal stability
def: "decrease in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0010094 ! abnormal chromosome stability
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T01:43:48Z

[Term]
id: MP:0010096
name: abnormal incisor color
def: "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal incisor colour" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0013129 ! abnormal tooth color
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T01:47:52Z

[Term]
id: MP:0010097
name: abnormal retina blood vessel morphology
def: "any structural anomaly of any of the blood vessels supplying the retina" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal retinal blood vessel morphology" EXACT []
synonym: "abnormal retinal blood vessel structure" EXACT []
is_a: MP:0002792 ! abnormal retina vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T02:18:50Z

[Term]
id: MP:0010098
name: abnormal retina blood vessel pattern
def: "anomaly in the systematic arrangement of the blood vessels supplying the retina" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal retinal blood vessel pattern" EXACT []
is_a: MP:0002792 ! abnormal retina vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T02:18:59Z

[Term]
id: MP:0010099
name: abnormal thoracic cage shape
def: "anomaly in the overall regular dome shape of the ribcage" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal rib cage shape" EXACT []
synonym: "abnormal ribcage shape" EXACT []
synonym: "abnormal thoracic basket shape" EXACT []
is_a: MP:0004624 ! abnormal thoracic cage morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T02:26:00Z

[Term]
id: MP:0010100
name: increased cervical vertebrae number
def: "increased number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000464 ! increased presacral vertebrae number
is_a: MP:0003048 ! abnormal cervical vertebrae morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T03:40:08Z

[Term]
id: MP:0010101
name: increased sacral vertebrae number
def: "increase of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0003050 ! abnormal sacral vertebrae morphology
is_a: MP:0004644 ! increased vertebrae number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T03:40:58Z

[Term]
id: MP:0010102
name: increased caudal vertebrae number
def: "increased number of the bony segments of the coccyx or tail" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased tail vertebrae number" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0004644 ! increased vertebrae number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-03-29T03:41:53Z

[Term]
id: MP:0010103
name: small thoracic cage
def: "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased thoracic cage size" EXACT []
synonym: "reduced thoracic cage size" EXACT []
synonym: "small rib cage" EXACT []
synonym: "small ribcage" EXACT []
synonym: "small thoracic basket" EXACT []
is_a: MP:0004624 ! abnormal thoracic cage morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-01T09:37:12Z

[Term]
id: MP:0010104
name: enlarged thoracic cage
def: "increased size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged rib cage" EXACT []
synonym: "enlarged ribcage" EXACT []
synonym: "enlarged thoracic basket" EXACT []
synonym: "increased thoracic cage size" EXACT []
is_a: MP:0004624 ! abnormal thoracic cage morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-01T09:37:36Z

[Term]
id: MP:0010105
name: abnormal sublingual ganglion morphology
def: "any structural anomaly of the small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland" [ISBN:0-683-40008-8]
synonym: "abnormal lingual ganglion morphology" EXACT []
xref: MA:0002982
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-08T12:19:52Z

[Term]
id: MP:0010106
name: abnormal circulating pyruvate kinase level
def: "abnormal concentration in the blood of the phosphotransferase in the glycolytic pathway that catalyzes the transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and p; deficiency results in hemolytic anemia" [ISBN:0-683-40008-8]
synonym: "abnormal circulating ATP:pyruvate 2-O-phosphotransferase level" EXACT []
synonym: "abnormal circulating phosphoenol transphosphorylase level" EXACT []
synonym: "abnormal circulating phosphoenolpyruvate kinase level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-08T01:26:15Z

[Term]
id: MP:0010107
name: abnormal renal reabsorption
def: "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney reabsorption" EXACT []
synonym: "abnormal kidney reuptake" EXACT []
synonym: "abnormal kidney uptake" EXACT []
synonym: "abnormal nephron absorption" EXACT []
synonym: "abnormal renal basolateral membrane transport" NARROW []
synonym: "abnormal renal basolateral membrane uptake" NARROW []
synonym: "abnormal renal brush border transport" NARROW []
synonym: "abnormal renal brush border uptake" NARROW []
synonym: "abnormal renal reuptake" EXACT []
synonym: "abnormal renal uptake" EXACT []
xref: GO:0070293
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T10:41:11Z

[Term]
id: MP:0010108
name: abnormal renal water reabsorption
def: "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney water reabsorption" EXACT []
synonym: "abnormal nephron water absorption" EXACT []
synonym: "abnormal renal water absorption" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation
is_a: MP:0010107 ! abnormal renal reabsorption
is_a: MP:0011443 ! abnormal renal water transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T10:46:15Z

[Term]
id: MP:0010109
name: abnormal renal sodium reabsorption
def: "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney sodium reabsorption" EXACT []
synonym: "abnormal renal sodium ion reabsorption" EXACT []
is_a: MP:0010107 ! abnormal renal reabsorption
is_a: MP:0011442 ! abnormal renal sodium ion transport
is_a: MP:0011977 ! abnormal sodium ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T10:47:28Z

[Term]
id: MP:0010110
name: abnormal renal phosphate reabsorption
def: "any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney phosphate reabsorption" EXACT []
synonym: "abnormal phosphate reuptake" EXACT []
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0010107 ! abnormal renal reabsorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T10:48:24Z

[Term]
id: MP:0010111
name: abnormal renal calcium reabsorption
def: "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney calcium reabsorption" EXACT []
synonym: "abnormal renal calcium absorption" EXACT []
synonym: "abnormal renal calcium ion reabsorption" EXACT []
is_a: MP:0004231 ! abnormal calcium ion homeostasis
is_a: MP:0010107 ! abnormal renal reabsorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T10:49:27Z

[Term]
id: MP:0010112
name: obsolete abnormal coccygeal vertebrae morphology
def: "any structural anomaly of the 3-5 separate or fused bony segments of the coccyx" [https://orcid.org/0000-0003-3691-0324]
comment: In humans and other tailless primates (e.g. great apes), the coccyx is the remnant or a vestigial tail. It consists of 3-5 separate or fused vertebrae (the coccygeal vertebrae) below the sacrum.
synonym: "abnormal coccyx vertebra" EXACT []
is_obsolete: true
replaced_by: MP:0002759

[Term]
id: MP:0010113
name: abnormal sacrum morphology
def: "any structural anomaly of the segment of the vertebral column that is formed by the fusion of five sacral vertebrae in adult humans and tailless primates" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal vertebra magna morphology" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T12:50:12Z

[Term]
id: MP:0010114
name: abnormal coccyx morphology
def: "any structural anomaly of the rostral-most segment of the vertebral column that is formed by the fusion of three to five coccygeal vertebrae in adult humans and tailless primates" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: In humans and other tailless primates (e.g. great apes), the coccyx is the remnant of a vestigial tail. It consists of 3-5 separate or fused vertebrae (the coccygeal vertebrae) below the sacrum.
synonym: "abnormal tail bone morphology" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-09T01:06:05Z

[Term]
id: MP:0010115
name: abnormal embryonic cloaca morphology
def: "any structural anomaly of the endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T12:32:44Z

[Term]
id: MP:0010116
name: abnormal primitive urogenital sinus morphology
def: "any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8]
comment: Note that the term "urogenital sinus" may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal.
synonym: "abnormal UGS morphology" EXACT []
is_a: MP:0010115 ! abnormal embryonic cloaca morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T12:33:14Z

[Term]
id: MP:0010117
name: abnormal lateral plate mesoderm morphology
def: "any structural anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8]
synonym: "abnormal lateral mesenchyme morphology" EXACT []
synonym: "abnormal lateral mesoderm" EXACT []
synonym: "abnormal lateral plate mesenchyme" EXACT []
synonym: "abnormal LPM morphology" EXACT []
is_a: MP:0014141 ! abnormal mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T01:16:08Z

[Term]
id: MP:0010118
name: abnormal intermediate mesoderm morphology
def: "any anomaly of the band of mesoderm located between the segmented paraxial mesoderm and the lateral plate mesoderm, that develops into the nephrogenic cord" [ISBN:0-683-40008-8]
synonym: "intermediate cell mass" EXACT []
is_a: MP:0014141 ! abnormal mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T01:16:29Z

[Term]
id: MP:0010119
name: abnormal bone mineral density
alt_id: MP:0005007
def: "anomaly in the quatitative measurment of mineral content of bone; BMD is used as an indicator of bone strength; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8]
synonym: "abnormal BMD" EXACT []
synonym: "abnormal bone density" EXACT []
synonym: "bone density anomalies" EXACT []
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T01:56:16Z

[Term]
id: MP:0010122
name: abnormal bone mineral content
def: "any anomaly in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal BMC" EXACT []
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T02:01:05Z

[Term]
id: MP:0010123
name: increased bone mineral content
def: "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "elevated BMC" EXACT []
synonym: "elevated bone mineral content" EXACT []
synonym: "increased BMC" EXACT []
is_a: MP:0010122 ! abnormal bone mineral content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T02:01:31Z

[Term]
id: MP:0010124
name: decreased bone mineral content
def: "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased BMC" EXACT []
synonym: "reduced BMC" EXACT []
synonym: "reduced bone mineral content" EXACT []
is_a: MP:0010122 ! abnormal bone mineral content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T02:02:01Z

[Term]
id: MP:0010125
name: abnormal parvocellular neurosecretory cell morphology
def: "any structural anomaly of the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system" [PMID:8543155]
synonym: "abnormal parvocellular neuron morphology" EXACT []
synonym: "abnormal parvocellular neurosecretory neuron morphology" EXACT []
is_a: MP:0008845 ! abnormal paraventricular hypothalamic nucleus morphology
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T03:13:01Z

[Term]
id: MP:0010126
name: abnormal distal visceral endoderm morphology
def: "any structural anomaly of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo" [https://orcid.org/0000-0003-3691-0324, PMID:17387317]
synonym: "abnormal DVE morphology" EXACT []
is_a: MP:0011186 ! abnormal visceral endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-12T04:06:42Z

[Term]
id: MP:0010127
name: hypervolemia
def: "an abnormally increased amount of space occupied by blood in the vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "high blood volume" EXACT []
synonym: "hypervolaemia" EXACT []
synonym: "increased plasma volume" NARROW []
is_a: MP:0001599 ! abnormal blood volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-13T03:58:30Z

[Term]
id: MP:0010128
name: hypovolemia
def: "an abnormally decreased amount of space occupied by blood in the vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma volume" NARROW []
synonym: "hypovolaemia" EXACT []
is_a: MP:0001599 ! abnormal blood volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-13T03:59:21Z

[Term]
id: MP:0010129
name: increased DN1 thymic pro-T cell number
def: "increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
synonym: "increased DN1 thymic pro-T lymphocyte number" EXACT []
synonym: "increased DN1 thymic pro-T-cell number" EXACT []
synonym: "increased DN1 thymic pro-T-lymphocyte number" EXACT []
synonym: "increased DN1 thymic progenitor T cell number" EXACT []
synonym: "increased DN1 thymocyte number" EXACT []
xref: CL:0000894
is_a: MP:0000714 ! increased thymocyte number
is_a: MP:0005090 ! increased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:51:59Z

[Term]
id: MP:0010130
name: decreased DN1 thymic pro-T cell number
def: "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
synonym: "decreased DN1 thymic pro-T lymphocyte number" EXACT []
synonym: "decreased DN1 thymic pro-T-cell number" EXACT []
synonym: "decreased DN1 thymic pro-T-lymphocyte number" EXACT []
synonym: "decreased DN1 thymic progenitor T cell number" EXACT []
synonym: "decreased DN1 thymocyte number" EXACT []
synonym: "reduced DN1 thymic pro-T cell number" EXACT []
synonym: "reduced DN1 thymic pro-T lymphocyte number" EXACT []
synonym: "reduced DN1 thymic pro-T-cell number" EXACT []
synonym: "reduced DN1 thymic pro-T-lymphocyte number" EXACT []
synonym: "reduced DN1 thymic progenitor T cell number" EXACT []
synonym: "reduced DN1 thymocyte number" EXACT []
xref: CL:0000894
is_a: MP:0000715 ! decreased thymocyte number
is_a: MP:0005089 ! decreased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:53:53Z

[Term]
id: MP:0010131
name: increased DN2 thymocyte number
def: "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains.
synonym: "increased DN2 alpha-beta immature T lymphocyte number" EXACT []
synonym: "increased DN2 alpha-beta immature T-cell number" EXACT []
synonym: "increased DN2 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "increased DN2 cell number" EXACT []
synonym: "increased DN2 immature T cell number" EXACT []
synonym: "increased TN2 cell number" EXACT []
synonym: "increased TN2 thymocyte number" EXACT []
xref: CL:0000806
is_a: MP:0000714 ! increased thymocyte number
is_a: MP:0005090 ! increased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:57:06Z

[Term]
id: MP:0010132
name: decreased DN2 thymocyte number
def: "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains.
synonym: "decreased DN2 alpha-beta immature T lymphocyte number" EXACT []
synonym: "decreased DN2 alpha-beta immature T-cell number" EXACT []
synonym: "decreased DN2 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "decreased DN2 cell number" EXACT []
synonym: "decreased DN2 immature T cell number" EXACT []
synonym: "decreased TN2 cell number" EXACT []
synonym: "decreased TN2 thymocyte number" EXACT []
synonym: "reduced DN2 alpha-beta immature T lymphocyte number" EXACT []
synonym: "reduced DN2 alpha-beta immature T-cell number" EXACT []
synonym: "reduced DN2 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "reduced DN2 cell number" EXACT []
synonym: "reduced DN2 immature T cell number" EXACT []
synonym: "reduced DN2 thymocyte number" EXACT []
synonym: "reduced TN2 cell number" EXACT []
synonym: "reduced TN2 thymocyte number" EXACT []
xref: CL:0000806
is_a: MP:0000715 ! decreased thymocyte number
is_a: MP:0005089 ! decreased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:59:07Z

[Term]
id: MP:0010133
name: increased DN3 thymocyte number
def: "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
synonym: "increased DN3 alpha-beta immature T lymphocyte number" EXACT []
synonym: "increased DN3 alpha-beta immature T-cell number" EXACT []
synonym: "increased DN3 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "increased DN3 cell number" EXACT []
synonym: "increased DN3 immature T cell number" EXACT []
synonym: "increased TN3 cell number" EXACT []
synonym: "increased TN3 thymocyte number" EXACT []
xref: CL:0000807
is_a: MP:0000714 ! increased thymocyte number
is_a: MP:0005090 ! increased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:59:28Z

[Term]
id: MP:0010134
name: decreased DN3 thymocyte number
def: "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
synonym: "decreased DN3 alpha-beta immature T lymphocyte number" EXACT []
synonym: "decreased DN3 alpha-beta immature T-cell number" EXACT []
synonym: "decreased DN3 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "decreased DN3 cell number" EXACT []
synonym: "decreased DN3 immature T cell number" EXACT []
synonym: "decreased TN3 cell number" EXACT []
synonym: "decreased TN3 thymocyte number" EXACT []
synonym: "reduced DN3 alpha-beta immature T lymphocyte number" EXACT []
synonym: "reduced DN3 alpha-beta immature T-cell number" EXACT []
synonym: "reduced DN3 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "reduced DN3 cell number" EXACT []
synonym: "reduced DN3 immature T cell number" EXACT []
synonym: "reduced DN3 thymocyte number" EXACT []
synonym: "reduced TN3 cell number" EXACT []
synonym: "reduced TN3 thymocyte number" EXACT []
xref: CL:0000807
is_a: MP:0000715 ! decreased thymocyte number
is_a: MP:0005089 ! decreased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T02:59:48Z

[Term]
id: MP:0010135
name: increased DN4 thymocyte number
def: "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
synonym: "increased DN4 alpha-beta immature T lymphocyte number" EXACT []
synonym: "increased DN4 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "increased DN4 cell number" EXACT []
synonym: "increased DN4 immature T cell number" EXACT []
synonym: "increased DN4 immature T-cell number" EXACT []
xref: CL:0000808
is_a: MP:0000714 ! increased thymocyte number
is_a: MP:0005090 ! increased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T03:00:10Z

[Term]
id: MP:0010136
name: decreased DN4 thymocyte number
def: "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
synonym: "decreased DN4 alpha-beta immature T lymphocyte number" EXACT []
synonym: "decreased DN4 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "decreased DN4 cell number" EXACT []
synonym: "decreased DN4 immature T cell number" EXACT []
synonym: "decreased DN4 immature T-cell number" EXACT []
synonym: "reduced DN4 alpha-beta immature T lymphocyte number" EXACT []
synonym: "reduced DN4 alpha-beta immature T-lymphocyte number" EXACT []
synonym: "reduced DN4 cell number" EXACT []
synonym: "reduced DN4 immature T cell number" EXACT []
synonym: "reduced DN4 immature T-cell number" EXACT []
synonym: "reduced DN4 thymocyte number" EXACT []
xref: CL:0000808
is_a: MP:0000715 ! decreased thymocyte number
is_a: MP:0005089 ! decreased double-negative T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-04-14T03:00:30Z

[Term]
id: MP:0010137
name: delayed exit from anagen phase
def: "anomaly in the growth phase of the hair cycle resulting a prolonged anagen phase" [https://orcid.org/0000-0002-8404-2907]
subset: IMPC
subset: Sanger_Terms
synonym: "extended anagen phase" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "increased anagen phase duration" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "prolonged anagen phase" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008858 ! abnormal hair cycle anagen phase
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T11:20:34Z

[Term]
id: MP:0010138
name: arteritis
def: "inflammation of the walls of arteries, usually as a result of infection or autoimmune response" [https://orcid.org/0000-0002-6490-7723]
synonym: "arterial inflammation" EXACT []
is_a: MP:0001863 ! blood vessel inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T11:33:59Z

[Term]
id: MP:0010139
name: aortitis
def: "inflammation of the aorta" [https://orcid.org/0000-0002-6490-7723]
synonym: "aorta inflammation" EXACT []
is_a: MP:0010138 ! arteritis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T11:35:09Z

[Term]
id: MP:0010140
name: phlebitis
def: "inflammation of a vein" [https://orcid.org/0000-0002-6490-7723]
synonym: "vein inflammation" EXACT []
synonym: "venous inflammation" EXACT []
is_a: MP:0001863 ! blood vessel inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T11:37:22Z

[Term]
id: MP:0010141
name: lymphangitis
def: "inflammation of the lymphatic vessels/channels" [https://orcid.org/0000-0002-6490-7723]
synonym: "lymph vessel inflammation" EXACT []
synonym: "lymphatic channel inflammation" EXACT []
synonym: "lymphatic vessel inflammation" EXACT []
is_a: MP:0001864 ! vascular inflammation
is_a: MP:0010368 ! abnormal lymphatic system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T11:38:46Z

[Term]
id: MP:0010142
name: disorganized hair shaft
def: "derangement of the normal pattern of the layered structure of the cuticle, cortex and/or medulla of a hair" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised hair shaft" EXACT []
is_a: MP:0003809 ! abnormal hair shaft morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-05T03:27:36Z

[Term]
id: MP:0010143
name: enhanced fertility
def: "increased physiological ability to produce live offspring" [https://orcid.org/0000-0003-0431-8641]
synonym: "increased fertility" EXACT []
is_a: MP:0002161 ! abnormal fertility/fecundity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T12:43:08Z

[Term]
id: MP:0010144
name: abnormal tumor vascularization
def: "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [https://orcid.org/0000-0003-0431-8641]
synonym: "abnormal tumor angiogenesis" EXACT []
synonym: "abnormal tumour angiogenesis" EXACT []
synonym: "abnormal tumour vascularization" EXACT []
is_a: MP:0000260 ! abnormal angiogenesis
is_a: MP:0021056 ! abnormal tumor vascular morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T01:02:25Z

[Term]
id: MP:0010145
name: abnormal spermatic cord morphology
def: "any structural anomaly of the cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis" [MGI:llw2]
is_a: MP:0009205 ! abnormal internal male genitalia morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T02:31:11Z

[Term]
id: MP:0010146
name: umbilical hernia
def: "an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the umbilicus; occurs when the muscle through which blood vessels pass to feed the developing fetus fails to completely close" [https://orcid.org/0000-0003-4606-0597, PMID:20333300]
comment: Do not confuse with omphalocele - a severe body wall defect that results in an abnormally large umbilical ring usually exposing the gut and liver.
subset: CvDC_Terms
xref: Fyler:4445
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T02:40:34Z

[Term]
id: MP:0010147
name: abnormal endocrine pancreas physiology
def: "any functional anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002693 ! abnormal pancreas physiology
is_a: MP:0013561 ! abnormal endocrine gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T03:24:28Z

[Term]
id: MP:0010148
name: abnormal exocrine pancreas physiology
def: "any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [https://orcid.org/0000-0003-3691-0324, MESH:A03.734.540]
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0002693 ! abnormal pancreas physiology
is_a: MP:0013559 ! abnormal exocrine gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T03:24:55Z

[Term]
id: MP:0010149
name: abnormal synaptic dopamine release
def: "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005445 ! abnormal neurotransmitter secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T03:41:12Z

[Term]
id: MP:0010150
name: abnormal mandibular ramus morphology
def: "any structural anomaly of the upturned perpendicular extremity of the mandible" [ISBN:0-683-40008-8]
synonym: "abnormal mandible ramus morphology" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-10T04:12:38Z

[Term]
id: MP:0010151
name: abnormal spinal cord ependymal layer morphology
def: "any structural anomaly of the cellular membrane that lines the central canal of the spinal cord" [ISBN:0-683-40008-8]
synonym: "abnormal spinal cord ventricular layer morphology" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology
is_a: MP:0002653 ! abnormal ependyma morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-11T10:47:16Z

[Term]
id: MP:0010152
name: abnormal brain ependyma morphology
def: "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8]
is_a: MP:0000822 ! abnormal brain ventricle morphology
is_a: MP:0002653 ! abnormal ependyma morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-11T12:21:52Z

[Term]
id: MP:0010153
name: abnormal gastroesophageal sphincter morphology
def: "any structural anomaly of the thick circular layer of smooth gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach" [ISBN:0-683-40008-8]
synonym: "abnormal cardiac sphincter morphology" EXACT []
synonym: "abnormal constrictor cardiae morphology" RELATED []
synonym: "abnormal esophageal sphincter morphology" BROAD []
synonym: "abnormal inferior esophageal sphincter morphology" EXACT []
synonym: "abnormal inferior oesophageal sphincter morphology" EXACT []
synonym: "abnormal lower esophageal sphincter morphology" EXACT []
synonym: "abnormal lower oesophageal sphincter morphology" EXACT []
synonym: "abnormal oesophageal sphincter morphology" BROAD []
xref: MA:0002951
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0010798 ! abnormal stomach cardiac region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-11T03:05:45Z

[Term]
id: MP:0010154
name: abnormal gastroesophageal sphincter physiology
def: "any functional anomaly of the thick circular layer of gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach" [ISBN:0-683-40008-8]
synonym: "abnormal cardiac sphincter physiology" EXACT []
synonym: "abnormal constrictor cardiae physiology" RELATED []
synonym: "abnormal esophageal sphincter physiology" BROAD []
synonym: "abnormal inferior esophageal sphincter physiology" EXACT []
synonym: "abnormal inferior oesophageal sphincter physiology" EXACT []
synonym: "abnormal lower esophageal sphincter physiology" EXACT []
synonym: "abnormal lower oesophageal sphincter physiology" EXACT []
synonym: "abnormal oesophageal sphincter physiology" BROAD []
xref: MA:0002951
is_a: MP:0001663 ! abnormal digestive system physiology
is_a: MP:0002106 ! abnormal muscle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-11T03:14:07Z

[Term]
id: MP:0010155
name: abnormal intestine physiology
def: "any functional anomaly of the digestive tube passing from the stomach to the anus" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001663 ! abnormal digestive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:04:15Z

[Term]
id: MP:0010156
name: abnormal small intestinal crypt cell physiology
def: "any functional anomaly of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [https://orcid.org/0000-0001-5013-1234]
is_a: MP:0014201 ! abnormal intestinal epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:13:57Z

[Term]
id: MP:0010157
name: abnormal small intestinal crypt cell proliferation
def: "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [https://orcid.org/0000-0001-5013-1234]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0010156 ! abnormal small intestinal crypt cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:15:31Z

[Term]
id: MP:0010158
name: abnormal intestine development
def: "abnormal formation of the digestive tube passing from the stomach to the anus" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0003119 ! abnormal digestive system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:19:24Z

[Term]
id: MP:0010159
name: abnormal enterocyte differentiation
def: "abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0010158 ! abnormal intestine development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:20:02Z

[Term]
id: MP:0010160
name: increased oligodendrocyte number
def: "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [https://orcid.org/0000-0003-3691-0324, MESH:A08.637.600]
synonym: "increased oligodendroglia number" EXACT []
synonym: "increased oligodendroglial cell number" EXACT []
synonym: "increased oligoglia number" EXACT []
synonym: "increased oligoglial cell number" EXACT []
is_a: MP:0000953 ! abnormal oligodendrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T02:58:43Z

[Term]
id: MP:0010161
name: decreased brain cholesterol level
def: "less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced brain cholesterol level" EXACT []
is_a: MP:0003983 ! decreased cholesterol level
is_a: MP:0012227 ! decreased brain sterol level
is_a: MP:0012779 ! abnormal brain cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T03:17:01Z

[Term]
id: MP:0010162
name: increased brain cholesterol level
def: "greater than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003982 ! increased cholesterol level
is_a: MP:0012228 ! increased brain sterol level
is_a: MP:0012779 ! abnormal brain cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-12T03:18:53Z

[Term]
id: MP:0010163
name: hemolysis
alt_id: MP:0010164
def: "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8]
synonym: "erythrocytolysis" EXACT []
synonym: "erythrolysis" EXACT []
synonym: "haematolysis" EXACT []
synonym: "haemolysis" EXACT []
synonym: "hematolysis" EXACT []
synonym: "increased haemolysis" EXACT []
synonym: "increased hemolysis" EXACT []
is_a: MP:0003656 ! abnormal erythrocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-05-21T02:13:18Z

[Term]
id: MP:0010165
name: abnormal response to stress-induced hyperthermia
def: "any anomaly in the expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
synonym: "abnormal SIH response" EXACT []
is_a: MP:0002572 ! abnormal emotion/affect behavior
is_a: MP:0011019 ! abnormal adaptive thermogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2010-05-28T02:42:40Z

[Term]
id: MP:0010166
name: increased response to stress-induced hyperthermia
def: "greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
subset: IMPC
subset: Sanger_Terms
synonym: "increased SIH response" EXACT []
is_a: MP:0010165 ! abnormal response to stress-induced hyperthermia
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2010-05-28T02:47:58Z

[Term]
id: MP:0010167
name: decreased response to stress-induced hyperthermia
def: "reduction or absence of the expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased SIH response" EXACT []
is_a: MP:0010165 ! abnormal response to stress-induced hyperthermia
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2010-05-28T02:48:26Z

[Term]
id: MP:0010168
name: increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
synonym: "increased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number" EXACT []
synonym: "increased CD4-positive, CD25-positive, alpha-beta regulatory T-cell number" EXACT []
synonym: "increased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number" EXACT []
synonym: "increased CD4-positive, CD25-positive, alpha-beta Treg number" EXACT []
synonym: "increased suppressor T cell number" BROAD []
synonym: "increased suppressor T lymphocyte number" BROAD []
synonym: "increased suppressor T-cell number" BROAD []
synonym: "increased suppressor T-lymphocyte number" BROAD []
xref: CL:0000792
is_a: MP:0004973 ! increased regulatory T cell number
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0012773 ! abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2010-05-28T03:27:31Z

[Term]
id: MP:0010169
name: decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
synonym: "decreased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number" EXACT []
synonym: "decreased CD4-positive, CD25-positive, alpha-beta regulatory T-cell number" EXACT []
synonym: "decreased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number" EXACT []
synonym: "decreased CD4-positive, CD25-positive, alpha-beta Treg number" EXACT []
synonym: "decreased suppressor T cell number" BROAD []
synonym: "decreased suppressor T lymphocyte number" BROAD []
synonym: "decreased suppressor T-cell number" BROAD []
synonym: "decreased suppressor T-lymphocyte number" BROAD []
synonym: "reduced CD4-positive, CD25-positive, alpha-beta regulatory T cell number" EXACT []
synonym: "reduced CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number" EXACT []
synonym: "reduced CD4-positive, CD25-positive, alpha-beta regulatory T-cell number" EXACT []
synonym: "reduced CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number" EXACT []
synonym: "reduced CD4-positive, CD25-positive, alpha-beta Treg number" EXACT []
synonym: "reduced suppressor T cell number" BROAD []
synonym: "reduced suppressor T lymphocyte number" BROAD []
synonym: "reduced suppressor T-cell number" BROAD []
synonym: "reduced suppressor T-lymphocyte number" BROAD []
xref: CL:0000792
is_a: MP:0004974 ! decreased regulatory T cell number
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0012773 ! abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2010-05-28T03:28:42Z

[Term]
id: MP:0010170
name: abnormal glial cell apoptosis
def: "change in the timing or the number of glial cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glia apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0003690 ! abnormal glial cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T02:20:10Z

[Term]
id: MP:0010171
name: abnormal centroacinar cell of Langerhans morphology
def: "any structural anomaly of the cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the pancreatic acinus; this cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types" [CL:0002080]
comment: Centroacinar cells liet at the junction between the acinus and the ductal cells of the intercalated duct, are smaller than acinar cells, have a high nuclear-to-cytoplasm ratio, and have long cytoplasmic processes that allow contact with other cells (i.e., centroacinar, acinar, and islet cells). Some authors suggest that centroacinar cells could represent progenitor multipotent pancreatic cells and potentially be involved in malignant transformation {comment="PMID:20018761", comment="https://doi.org/10.1016/B978-0-323-34062-5.00004-2"}
synonym: "abnormal centro-acinar cell of Langerhans morphology" EXACT []
synonym: "abnormal pancreatic centro-acinar cell morphology" EXACT []
synonym: "abnormal pancreatic centroacinar cell morphology" EXACT []
is_a: MP:0009145 ! abnormal pancreatic acinus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T02:40:50Z

[Term]
id: MP:0010172
name: abnormal mammary gland epithelium physiology
def: "any functional anomaly of the mammary gland epithelium which is normally enveloped by a basement membrane, embedded into fatty connective tissue stroma, and organized as a bilayer, with an inner luminal layer of secretory epithelial cells, and an outer basal layer; each cell layer expresses specific molecular markers; luminal epithelial cells are characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin, whereas basal cells (aka myoepithelial cells) express smooth muscle contractile proteins; in functionally differentiated mammary gland, during lactation, luminal cells produce milk, whereas myoepithelial cells are contractile and serve for milk expulsion" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001881 ! abnormal mammary gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T02:55:12Z

[Term]
id: MP:0010173
name: increased mammary gland epithelial cell proliferation
def: "increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mammary gland epithelium proliferation" BROAD []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0010172 ! abnormal mammary gland epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T02:55:42Z

[Term]
id: MP:0010174
name: decreased mammary gland epithelial cell proliferation
def: "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mammary gland epithelium proliferation" BROAD []
synonym: "reduced mammary gland epithelial cell proliferation" EXACT []
synonym: "reduced mammary gland epithelium proliferation" BROAD []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0010172 ! abnormal mammary gland epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T03:03:57Z

[Term]
id: MP:0010175
name: leptocytosis
def: "the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull's-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased codocyte number" EXACT []
synonym: "increased Mexican hat cell number" EXACT []
synonym: "increased target cell number" EXACT []
synonym: "Mexican hat erythrocytes" EXACT []
synonym: "target erythrocytes" EXACT []
synonym: "wafer-thin erythrocytes" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T03:33:04Z

[Term]
id: MP:0010176
name: dacryocytosis
def: "presence of teardrop-shaped red blood cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "tear-shaped erythrocytes" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T04:00:22Z

[Term]
id: MP:0010177
name: acanthocytosis
def: "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [https://orcid.org/0000-0002-6490-7723]
synonym: "spiculated red blood cells" EXACT []
synonym: "spike red blood cells" EXACT []
synonym: "spikey erythrocytes" EXACT []
synonym: "spur red blood cells" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T04:03:45Z

[Term]
id: MP:0010178
name: increased number of Howell-Jolly bodies
def: "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased number of nuclear fragments in erythrocytes" EXACT []
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-01T04:06:18Z

[Term]
id: MP:0010179
name: rough coat
def: "coat does not have the usual smooth appearance" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0002074 ! abnormal hair texture
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T01:38:37Z

[Term]
id: MP:0010180
name: increased susceptibility to weight loss
def: "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction, infection or xenobiotic treatment" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011118 ! abnormal susceptibility to weight loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:10:44Z

[Term]
id: MP:0010181
name: decreased susceptibility to weight loss
def: "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction, infection or xenobiotic treatment" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011118 ! abnormal susceptibility to weight loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:15:40Z

[Term]
id: MP:0010182
name: decreased susceptibility to weight gain
def: "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011117 ! abnormal susceptibility to weight gain
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:16:40Z

[Term]
id: MP:0010183
name: abnormal CD4-positive helper T cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions" [CL:0000492, ISBN:0781735149]
xref: FMA:70572
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology
is_a: MP:0013760 ! abnormal T-helper cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:48:29Z

[Term]
id: MP:0010184
name: abnormal T follicular helper cell morphology
def: "any structural anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0010183 ! abnormal CD4-positive helper T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:51:32Z

[Term]
id: MP:0010185
name: abnormal T follicular helper cell number
def: "anomaly in the number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0010184 ! abnormal T follicular helper cell morphology
is_a: MP:0013761 ! abnormal T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:55:18Z

[Term]
id: MP:0010186
name: increased T follicular helper cell number
def: "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0010185 ! abnormal T follicular helper cell number
is_a: MP:0013763 ! increased T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:55:39Z

[Term]
id: MP:0010187
name: decreased T follicular helper cell number
def: "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0010185 ! abnormal T follicular helper cell number
is_a: MP:0013764 ! decreased T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:56:04Z

[Term]
id: MP:0010188
name: abnormal T follicular helper cell differentiation
def: "atypical production of or inability to produce the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0008076 ! abnormal CD4-positive T cell differentiation
is_a: MP:0010184 ! abnormal T follicular helper cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:56:29Z

[Term]
id: MP:0010189
name: abnormal T follicular helper cell physiology
def: "any functional anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
xref: CL:0002038
is_a: MP:0005463 ! abnormal CD4-positive, alpha-beta T cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-04T03:57:37Z

[Term]
id: MP:0010190
name: abnormal retina melanocyte morphology
def: "any structural anomaly of the cells that produce pigment in the retina" [ISBN:978-1-4051-2034-0]
synonym: "abnormal retinal melanocyte morphology" EXACT []
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0005103 ! abnormal retina pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-07T01:58:02Z

[Term]
id: MP:0010191
name: abnormal choroid melanocyte morphology
def: "any structural anomaly of the cells that produce pigment in the choroid" [ISBN:978-1-4051-2034-0]
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0005100 ! abnormal choroid pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-07T01:58:36Z

[Term]
id: MP:0010192
name: abnormal retina melanin granule morphology
def: "any structural anomaly of the pigment particles in the retina" [ISBN:978-1-4051-2034-0]
synonym: "abnormal retinal melanin granule morphology" EXACT []
is_a: MP:0005075 ! abnormal melanosome morphology
is_a: MP:0010190 ! abnormal retina melanocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-07T02:18:07Z

[Term]
id: MP:0010193
name: abnormal choroid melanin granule morphology
def: "any structural anomaly of the pigment particles in the choroid" [ISBN:978-1-4051-2034-0]
is_a: MP:0005075 ! abnormal melanosome morphology
is_a: MP:0010191 ! abnormal choroid melanocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-07T02:18:27Z

[Term]
id: MP:0010194
name: absent lymphatic vessels
def: "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8]
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:37:22Z

[Term]
id: MP:0010195
name: abnormal lymphatic vessel endothelium morphology
def: "any structural anomaly of the thin layer of flat cells that line the lymphatic vessels and form a barrier between circulating lymph in the lumen and the rest of the vessel wall" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000750
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:37:57Z

[Term]
id: MP:0010196
name: abnormal lymphatic vessel smooth muscle morphology
def: "any structural anomaly of the nonstriated, involuntary muscle tissue that encompasses the lymphatic vessels" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0000751
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:38:19Z

[Term]
id: MP:0010197
name: abnormal lymphatic vessel endothelial cell morphology
def: "any structural anomaly of the cells that line the lymphatic vessels" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010195 ! abnormal lymphatic vessel endothelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:39:31Z

[Term]
id: MP:0010198
name: decreased lymphatic vessel endothelial cell number
def: "reduced number of the cells that line the lymphatic vessels" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced lymphatic vessel endothelial cell number" EXACT []
is_a: MP:0010197 ! abnormal lymphatic vessel endothelial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:40:07Z

[Term]
id: MP:0010199
name: absent lymphatic vessel endothelial cells
def: "absence of the cells that line the lymphatic vessels" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010198 ! decreased lymphatic vessel endothelial cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:40:32Z

[Term]
id: MP:0010200
name: enlarged lymphatic vessel
def: "increased size of the lymphatic vessels which form a network that carries lymph around the body" [ISBN:0-683-40008-8]
synonym: "enlarged lymphatic vessels" EXACT []
synonym: "increased lymphatic vessel size" EXACT []
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T10:41:07Z

[Term]
id: MP:0010202
name: focal dorsal hair loss
def: "focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [https://orcid.org/0000-0002-8404-2907, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "dorsal skin visible" EXACT []
is_a: MP:0000418 ! focal hair loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T03:01:23Z

[Term]
id: MP:0010203
name: focal ventral hair loss
def: "focal hair loss on the ventral area of a rodent resulting in ventral skin visible in a patch where hair loss occurs" [https://orcid.org/0000-0002-8404-2907, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "ventral skin visible" EXACT []
is_a: MP:0000418 ! focal hair loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-11T03:04:09Z

[Term]
id: MP:0010204
name: abnormal astrocyte apoptosis
def: "change in the timing or the number of astrocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal astroglia apoptosis" EXACT []
synonym: "abnormal astroglial cell apoptosis" EXACT []
is_a: MP:0008916 ! abnormal astrocyte physiology
is_a: MP:0010170 ! abnormal glial cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-18T11:05:34Z

[Term]
id: MP:0010205
name: abnormal oligodendrocyte apoptosis
def: "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal oligodendroglia apoptosis" RELATED []
synonym: "abnormal oligodendroglial cell apoptosis" EXACT []
synonym: "abnormal oligoglia apoptosis" EXACT []
synonym: "abnormal oligoglial cell apoptosis" EXACT []
is_a: MP:0008917 ! abnormal oligodendrocyte physiology
is_a: MP:0010170 ! abnormal glial cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-18T11:08:21Z

[Term]
id: MP:0010206
name: pigment incontinence
def: "absence of melanin and melanosomes in the epidermis, and accumulation of melanin and melanosome in melanophages in the upper dermis" [https://orcid.org/0000-0003-3691-0324]
synonym: "incontinence of pigment" EXACT []
is_a: MP:0002095 ! abnormal skin pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-18T03:35:59Z

[Term]
id: MP:0010207
name: abnormal telomere morphology
def: "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003702 ! abnormal chromosome morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-22T01:20:58Z

[Term]
id: MP:0010208
name: prognathia
def: "abnormal protrusion of the mandible relative to the facial skeleton and soft tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "prognathism" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-06-22T03:12:19Z

[Term]
id: MP:0010209
name: abnormal circulating chemokine level
def: "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [https://orcid.org/0000-0003-3691-0324, MESH:D12.644.276.374.200]
comment: The site en.wikipedia.org/wiki/Chemokine has a good list of chemokines.
is_a: MP:0008721 ! abnormal chemokine level
is_a: MP:0010210 ! abnormal circulating cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T10:00:46Z

[Term]
id: MP:0010210
name: abnormal circulating cytokine level
def: "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-8153-1691-7]
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0008713 ! abnormal cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T10:02:09Z

[Term]
id: MP:0010211
name: abnormal acute phase protein level
def: "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7]
is_a: MP:0002419 ! abnormal innate immunity
is_a: MP:0002723 ! abnormal immune serum protein physiology
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T12:16:59Z

[Term]
id: MP:0010212
name: abnormal circulating C-reactive protein level
def: "deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8, MESH:D12.776.034.145]
synonym: "abnormal circulating CRP level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T01:11:19Z

[Term]
id: MP:0010213
name: abnormal circulating fibrinogen level
def: "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T01:21:44Z

[Term]
id: MP:0010214
name: abnormal circulating serum amyloid protein level
def: "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [https://orcid.org/0000-0003-3691-0324, MESH:D12.776.049.790]
synonym: "abnormal SAA protein level" EXACT []
synonym: "abnormal Serum Amyloid A Protein level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-05T01:22:14Z

[Term]
id: MP:0010215
name: abnormal circulating complement protein level
def: "deviation from the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circulating complement component level" RELATED []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0011566 ! abnormal complement protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T12:19:11Z

[Term]
id: MP:0010216
name: abnormal circulating retinol binding protein level
def: "anomaly in the blood level of carrier proteins that bind retinol; serum levels are used to detect liver disease, protein-calorie malnutrition and vitamin A deficiencies" [PMID:10839978]
synonym: "abnormal circulating CBP level" EXACT []
synonym: "abnormal circulating retinoid-binding protein level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T12:40:37Z

[Term]
id: MP:0010217
name: abnormal T-helper 17 cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "abnormal helper T cell type 17 morphology" EXACT []
synonym: "abnormal Th17 cell morphology" EXACT []
synonym: "abnormal Th17 T cell morphology" EXACT []
synonym: "abnormal Th17 T lymphocyte morphology" EXACT []
synonym: "abnormal Th17 T-cell morphology" EXACT []
synonym: "abnormal Th17 T-lymphocyte morphology" EXACT []
is_a: MP:0010183 ! abnormal CD4-positive helper T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:45:33Z

[Term]
id: MP:0010218
name: abnormal T-helper 17 cell number
def: "deviation from the normal count of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "abnormal helper T cell type 17 number" EXACT []
synonym: "abnormal Th17 cell number" EXACT []
synonym: "abnormal Th17 T cell number" EXACT []
synonym: "abnormal Th17 T lymphocyte number" EXACT []
synonym: "abnormal Th17 T-cell number" EXACT []
synonym: "abnormal Th17 T-lymphocyte number" EXACT []
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0010217 ! abnormal T-helper 17 cell morphology
is_a: MP:0013761 ! abnormal T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:47:34Z

[Term]
id: MP:0010219
name: increased T-helper 17 cell number
def: "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "increased helper T cell type 17 number" EXACT []
synonym: "increased Th17 cell number" EXACT []
synonym: "increased Th17 T cell number" EXACT []
synonym: "increased Th17 T lymphocyte number" EXACT []
synonym: "increased Th17 T-cell number" EXACT []
synonym: "increased Th17 T-lymphocyte number" EXACT []
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0010218 ! abnormal T-helper 17 cell number
is_a: MP:0013763 ! increased T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:47:54Z

[Term]
id: MP:0010220
name: decreased T-helper 17 cell number
def: "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "decreased helper T cell type 17 number" EXACT []
synonym: "decreased Th17 cell number" EXACT []
synonym: "decreased Th17 T cell number" EXACT []
synonym: "decreased Th17 T lymphocyte number" EXACT []
synonym: "decreased Th17 T-cell number" EXACT []
synonym: "decreased Th17 T-lymphocyte number" EXACT []
synonym: "dreduced Th17 T-lymphocyte number" EXACT []
synonym: "reduced helper T cell type 17 number" EXACT []
synonym: "reduced Th17 cell number" EXACT []
synonym: "reduced Th17 T cell number" EXACT []
synonym: "reduced Th17 T lymphocyte number" EXACT []
synonym: "reduced Th17 T-cell number" EXACT []
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0010218 ! abnormal T-helper 17 cell number
is_a: MP:0013764 ! decreased T-helper cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:48:15Z

[Term]
id: MP:0010221
name: abnormal T-helper 17 cell differentiation
def: "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "abnormal helper T cell type 17 differentiation" EXACT []
synonym: "abnormal Th17 cell differentiation" EXACT []
synonym: "abnormal Th17 T cell differentiation" EXACT []
synonym: "abnormal Th17 T lymphocyte differentiation" EXACT []
synonym: "abnormal Th17 T-cell differentiation" EXACT []
synonym: "abnormal Th17 T-lymphocyte differentiation" EXACT []
is_a: MP:0002145 ! abnormal T cell differentiation
is_a: MP:0010217 ! abnormal T-helper 17 cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:48:37Z

[Term]
id: MP:0010222
name: abnormal T-helper 17 cell physiology
def: "any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
synonym: "abnormal helper T cell type 17 physiology" EXACT []
synonym: "abnormal Th17 cell physiology" EXACT []
synonym: "abnormal Th17 T cell physiology" EXACT []
synonym: "abnormal Th17 T lymphocyte physiology" EXACT []
synonym: "abnormal Th17 T-cell physiology" EXACT []
synonym: "abnormal Th17 T-lymphocyte physiology" EXACT []
is_a: MP:0005463 ! abnormal CD4-positive, alpha-beta T cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-06T04:49:43Z

[Term]
id: MP:0010223
name: abnormal immunoglobulin transcytosis
def: "any anomaly in the process of transporting immunoglobulin, via transcytosis, from one side of a cell to the other; occurs in epithelial cells and other cell types" [GO:0002414, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001790 ! abnormal immune system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-07T03:42:50Z

[Term]
id: MP:0010224
name: abnormal heart ventricle outflow tract morphology
def: "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8]
synonym: "abnormal outflow part of ventricle morphology" EXACT []
synonym: "abnormal outflow path of ventricle morphology" EXACT []
synonym: "abnormal outflow tract of ventricle morphology" EXACT []
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-07T04:27:25Z

[Term]
id: MP:0010225
name: abnormal quadriceps morphology
def: "any structural anomaly of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal quadriceps extensor morphology" EXACT []
synonym: "abnormal quadriceps femoris morphology" EXACT []
synonym: "abnormal quadriceps muscle morphology" EXACT []
synonym: "abnormal quads morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0021206 ! abnormal limb muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-12T02:23:53Z

[Term]
id: MP:0010226
name: increased quadriceps weight
def: "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased quadriceps extensor weight" EXACT []
synonym: "increased quadriceps femoris weight" EXACT []
synonym: "increased quadriceps muscle weight" EXACT []
synonym: "increased quads weight" EXACT []
is_a: MP:0020164 ! abnormal quadriceps weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-12T02:36:45Z

[Term]
id: MP:0010227
name: decreased quadriceps weight
def: "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased quadriceps extensor weight" EXACT []
synonym: "decreased quadriceps femoris weight" EXACT []
synonym: "decreased quadriceps muscle weight" EXACT []
synonym: "decreased quads weight" EXACT []
synonym: "reduced quadriceps extensor weight" EXACT []
synonym: "reduced quadriceps femoris weight" EXACT []
synonym: "reduced quadriceps muscle weight" EXACT []
synonym: "reduced quadriceps weight" EXACT []
synonym: "reduced quads weight" EXACT []
is_a: MP:0020164 ! abnormal quadriceps weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-12T02:37:02Z

[Term]
id: MP:0010228
name: decreased transitional stage T3 B cell number
def: "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
synonym: "decreased T3 stage B cell number" EXACT []
synonym: "decreased transitional three stage B lymphocyte number" EXACT []
synonym: "decreased transitional three stage B-cell number" EXACT []
synonym: "decreased transitional three stage B-lymphocyte number" EXACT []
synonym: "reduced T3 stage B cell number" EXACT []
synonym: "reduced transitional three stage B lymphocyte number" EXACT []
synonym: "reduced transitional three stage B-cell number" EXACT []
synonym: "reduced transitional three stage B-lymphocyte number" EXACT []
xref: CL:0000960
is_a: MP:0008190 ! decreased transitional stage B cell number
is_a: MP:0009921 ! abnormal transitional stage T3 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-13T11:32:36Z

[Term]
id: MP:0010229
name: increased transitional stage T3 B cell number
def: "greater number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
synonym: "increased T3 stage B cell number" EXACT []
synonym: "increased transitional three stage B lymphocyte number" EXACT []
synonym: "increased transitional three stage B-cell number" EXACT []
synonym: "increased transitional three stage B-lymphocyte number" EXACT []
xref: CL:0000960
is_a: MP:0008189 ! increased transitional stage B cell number
is_a: MP:0009921 ! abnormal transitional stage T3 B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-13T11:32:54Z

[Term]
id: MP:0010230
name: absent transitional stage T3 B cells
def: "absence of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
synonym: "absent T3 stage B cells" EXACT []
synonym: "absent transitional three stage B lymphocytes" EXACT []
synonym: "absent transitional three stage B-lymphocytes" EXACT []
synonym: "dabsent transitional three stage B-cells" EXACT []
xref: CL:0000960
is_a: MP:0010228 ! decreased transitional stage T3 B cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-13T11:33:30Z

[Term]
id: MP:0010231
name: transverse fur striping
alt_id: MP:0006360
def: "presence of stripes of pigmented hair, usually black, of variable degree and location in the coat" [MGI:llw2]
synonym: "tabby coat" EXACT []
synonym: "transverse coat striping" RELATED []
synonym: "transverse fur markings" EXACT []
is_a: MP:0000372 ! irregular coat pigmentation
is_a: MP:0009659 ! striated fur
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-15T03:17:55Z

[Term]
id: MP:0010232
name: delayed skin pigmentation appearance
def: "lag in the time that normal coloration of the skin color occurs in relation to control animals" [MGI:llw2]
is_a: MP:0002095 ! abnormal skin pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-15T04:01:57Z

[Term]
id: MP:0010233
name: hairless tail
def: "the tail is devoid of hair" [MGI:llw2]
synonym: "absent tail hair" EXACT []
synonym: "glabrous tail" EXACT []
is_a: MP:0002111 ! abnormal tail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-15T04:37:12Z

[Term]
id: MP:0010234
name: abnormal vibrissa follicle morphology
def: "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2]
synonym: "abnormal contour hair follicle morphology" EXACT []
synonym: "abnormal sinus hair follicle morphology" EXACT []
synonym: "abnormal touch hair follicle morphology" EXACT []
is_a: MP:0010678 ! abnormal skin adnexa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-15T04:39:00Z

[Term]
id: MP:0010235
name: abnormal retina inner limiting membrane morphology
def: "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal retina ILM morphology" EXACT []
synonym: "abnormal retina internal limiting lamina morphology" EXACT []
synonym: "abnormal retina internal limiting membrane morphology" EXACT []
synonym: "abnormal retinal ILM morphology" EXACT []
synonym: "abnormal retinal inner limiting membrane morphology" EXACT []
synonym: "abnormal retinal internal limiting lamina morphology" EXACT []
synonym: "abnormal retinal internal limiting membrane morphology" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-16T10:38:04Z

[Term]
id: MP:0010236
name: abnormal retina outer limiting membrane morphology
def: "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal retina external limiting lamina morphology" EXACT []
synonym: "abnormal retina external limiting membrane morphology" RELATED []
synonym: "abnormal retina OLM morphology" EXACT []
synonym: "abnormal retinal external limiting lamina morphology" EXACT []
synonym: "abnormal retinal external limiting membrane morphology" EXACT []
synonym: "abnormal retinal OLM morphology" EXACT []
synonym: "abnormal retinal outer limiting membrane morphology" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-16T10:39:10Z

[Term]
id: MP:0010237
name: abnormal skeletal muscle weight
def: "any anomaly in the average skeletal muscle weight" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004233 ! abnormal muscle weight
is_a: MP:0009458 ! abnormal skeletal muscle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-19T12:49:29Z

[Term]
id: MP:0010238
name: increased skeletal muscle weight
def: "greater than average skeletal muscle weight" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003397 ! increased muscle weight
is_a: MP:0003398 ! increased skeletal muscle size
is_a: MP:0010237 ! abnormal skeletal muscle weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-19T01:12:06Z

[Term]
id: MP:0010239
name: decreased skeletal muscle weight
def: "less than average skeletal muscle weight" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004232 ! decreased muscle weight
is_a: MP:0010237 ! abnormal skeletal muscle weight
is_a: MP:0010240 ! decreased skeletal muscle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-19T01:12:26Z

[Term]
id: MP:0010240
name: decreased skeletal muscle size
def: "less than average dimensions of one or more of the muscles of the skeleton" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004819 ! decreased skeletal muscle mass
is_a: MP:0009458 ! abnormal skeletal muscle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-19T01:20:35Z

[Term]
id: MP:0010241
name: abnormal aortic arch development
def: "anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8]
synonym: "abnormal adult aortic arch development" RELATED []
synonym: "abnormal arch of aorta development" EXACT []
is_a: MP:0003410 ! abnormal artery development
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-19T03:04:01Z

[Term]
id: MP:0010242
name: abnormal kidney copper level
def: "an anomaly in the amount of copper present in kidney tissue" [MGI:llw2]
synonym: "abnormal renal copper level" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0003952 ! abnormal copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T12:21:08Z

[Term]
id: MP:0010243
name: increased kidney copper level
def: "a greater accumulation of copper in the kidney tissue compared to controls" [MGI:llw2]
synonym: "increased renal copper level" EXACT []
is_a: MP:0010242 ! abnormal kidney copper level
is_a: MP:0014539 ! increased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T12:27:15Z

[Term]
id: MP:0010244
name: decreased kidney copper level
def: "a reduced amount of copper in the kidney tissue compared to controls" [MGI:llw2]
synonym: "decreased renal copper level" EXACT []
synonym: "reduced kidney copper level" EXACT []
synonym: "reduced renal copper level" EXACT []
is_a: MP:0010242 ! abnormal kidney copper level
is_a: MP:0014540 ! decreased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T12:27:32Z

[Term]
id: MP:0010245
name: abnormal spleen perifollicular zone morphology
def: "any structural anomaly of the compartment located between the marginal zone and the red pulp harboring scattered B and T lymphocytes" [PMID:11485909, PMID:9415041]
comment: Note that there is no consensus in the literature about whether the perifollicular zone (which does not exist in rodents) is part of the splenic red or white pulp. Notable differences in the structure of the spleen exist between humans and rodents. In this ontology, the marginal sinus (which doen not exist in human) has been included as part of the white pulp and may be the rodent functional equivalent of the human perifollicular zone.
is_a: MP:0000689 ! abnormal spleen morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T01:22:05Z

[Term]
id: MP:0010246
name: abnormal intestine copper level
def: "an anomaly in the amount of copper present in the intestine" [MGI:llw2]
synonym: "abnormal intestinal copper level" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0003952 ! abnormal copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T02:44:25Z

[Term]
id: MP:0010247
name: increased intestine copper level
def: "a greater accumulation of copper in intestinal tissue compared with controls" [MGI:llw2]
synonym: "elevated intestine copper level" EXACT []
synonym: "increased intestinal copper level" EXACT []
is_a: MP:0010246 ! abnormal intestine copper level
is_a: MP:0014539 ! increased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T02:45:01Z

[Term]
id: MP:0010248
name: decreased intestine copper level
def: "a reduced amount of copper in the intestinal tissue compared to controls" [MGI:llw2]
synonym: "decreased intestinal copper level" EXACT []
synonym: "reduced intestinal copper level" EXACT []
synonym: "reduced intestine copper level" EXACT []
is_a: MP:0010246 ! abnormal intestine copper level
is_a: MP:0014540 ! decreased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T02:45:26Z

[Term]
id: MP:0010249
name: lactation failure
def: "mammary glands do not secrete milk after parturition" [MGI:llw2]
synonym: "agalactia" EXACT []
synonym: "agalactorrhea" EXACT []
synonym: "agalactosis" EXACT []
is_a: MP:0001882 ! abnormal lactation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T03:30:02Z

[Term]
id: MP:0010250
name: absent thymus cortex
def: "lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2]
is_a: MP:0002371 ! abnormal thymus cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-29T03:39:18Z

[Term]
id: MP:0010251
name: subcapsular cataract
def: "a lens opacity localized beneath the anterior or posterior lens capsule" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "subcapsular cataracts" EXACT []
synonym: "subcapsular opacity" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:42:20Z

[Term]
id: MP:0010252
name: anterior subcapsular cataract
def: "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "anterior subcapsular cataracts" EXACT []
synonym: "anterior subcapsular opacity" EXACT []
is_a: MP:0010251 ! subcapsular cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:42:40Z

[Term]
id: MP:0010253
name: posterior subcapsular cataract
def: "a lens opacity localized beneath the posterior lens capsule" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
subset: IMPC
subset: Sanger_Terms
synonym: "posterior subcapsular cataracts" EXACT []
synonym: "posterior subcapsular opacity" EXACT []
is_a: MP:0010251 ! subcapsular cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:43:01Z

[Term]
id: MP:0010254
name: nuclear cataract
def: "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "hard cataracts" EXACT []
synonym: "nuclear cataracts" EXACT []
synonym: "nuclear opacity" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:43:19Z

[Term]
id: MP:0010255
name: cortical cataract
def: "a lens opacity, frequently punctate, affecting the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "cortical cataracts" EXACT []
synonym: "cortical opacity" EXACT []
synonym: "peripheral cataracts" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:43:33Z

[Term]
id: MP:0010256
name: anterior cortical cataract
def: "a lens opacity, frequently punctate, affecting the anterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "anterior cortical cataracts" EXACT []
synonym: "anterior cortical opacity" EXACT []
synonym: "anterior peripheral cataracts" EXACT []
is_a: MP:0010255 ! cortical cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:43:44Z

[Term]
id: MP:0010257
name: posterior cortical cataract
def: "a lens opacity, frequently punctate, affecting the posterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "posterior cortical cataracts" EXACT []
synonym: "posterior cortical opacity" EXACT []
synonym: "posterior peripheral cataracts" EXACT []
is_a: MP:0010255 ! cortical cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:44:09Z

[Term]
id: MP:0010258
name: polar cataract
def: "a lens opacity, usually disk-shaped, that is limited to an area in the anterior or posterior pole of the lens capsular region" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "polar cataracts" EXACT []
synonym: "polar opacity" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:44:36Z

[Term]
id: MP:0010259
name: anterior polar cataract
def: "a lens opacity, usually disk-shaped, that is limited to an area in the anterior pole of the lens capsular region" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "anterior polar cataracts" EXACT []
synonym: "anterior polar opacity" EXACT []
is_a: MP:0010258 ! polar cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:44:47Z

[Term]
id: MP:0010260
name: posterior polar cataract
def: "a lens opacity, usually disk-shaped, that is limited to an area in the posterior pole of the lens capsular region" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "posterior polar cataracts" EXACT []
synonym: "posterior polar opacity" EXACT []
is_a: MP:0010258 ! polar cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:45:00Z

[Term]
id: MP:0010261
name: sutural cataract
def: "a lens opacity which follows the shape of anterior or posterior Y suture of the fetal lens and is not progressive; often more severe in males and is congenital, but usually does not affect vision" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "sutural cataracts" EXACT []
synonym: "sutural opacity" EXACT []
synonym: "suture cataracts" EXACT []
is_a: MP:0031345 ! developmental cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:45:29Z

[Term]
id: MP:0010262
name: lamellar cataract
def: "a concentric lens opacity which is limited to layers of the cortex, affecting one lamella or zonule of an otherwise clear lens; usually congenital" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "lamellar cataracts" EXACT []
synonym: "lamellar opacity" EXACT []
synonym: "zonular cataracts" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:45:59Z

[Term]
id: MP:0010263
name: total cataract
def: "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8, ISBN:978-0-8493-0864-2]
synonym: "complete cataracts" EXACT []
synonym: "total cataracts" EXACT []
synonym: "total lens opacity" EXACT []
is_a: MP:0001304 ! cataract
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-07-30T01:46:30Z

[Term]
id: MP:0010264
name: increased hepatoma incidence
alt_id: MP:0002028
alt_id: MP:0002889
def: "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to hepatoma" EXACT []
synonym: "increased malignant liver tumor incidence" EXACT []
synonym: "increased susceptibility to hepatoma" EXACT []
is_a: MP:0008019 ! increased liver tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T10:36:22Z

[Term]
id: MP:0010265
name: decreased hepatoma incidence
alt_id: MP:0002890
def: "less than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to hepatoma" EXACT []
synonym: "hepatoma resistance" EXACT []
synonym: "increased resistance to hepatoma" EXACT []
is_a: MP:0010266 ! decreased liver tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T10:44:04Z

[Term]
id: MP:0010266
name: decreased liver tumor incidence
alt_id: MP:0005513
def: "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased liver tumour incidence" EXACT []
synonym: "decreased susceptibility to liver neoplasm" EXACT []
synonym: "decreased susceptibility to liver tumor" EXACT []
synonym: "decreased susceptibility to liver tumour" EXACT []
synonym: "increased resistance to liver neoplasm" EXACT []
synonym: "increased resistance to liver tumor" EXACT []
synonym: "increased resistance to liver tumour" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0012421 ! decreased hepatobiliary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T10:47:13Z

[Term]
id: MP:0010267
name: decreased lung tumor incidence
alt_id: MP:0003640
def: "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lung tumour incidence" EXACT []
synonym: "decreased susceptibility to lung neoplasm" EXACT []
synonym: "increased resistance to lung neoplasm" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0012425 ! decreased respiratory system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:16:39Z

[Term]
id: MP:0010268
name: decreased lymphoma incidence
alt_id: MP:0003000
def: "less than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lymphosarcoma incidence" EXACT []
synonym: "decreased susceptibility to lymphoma" EXACT []
synonym: "increased resistance to lymphoma" EXACT []
is_a: MP:0010283 ! decreased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:24:28Z

[Term]
id: MP:0010269
name: decreased mammary gland tumor incidence
alt_id: MP:0005512
def: "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mammary gland tumour incidence" EXACT []
synonym: "decreased susceptibility to mammary neoplasm" EXACT []
synonym: "decreased susceptibility to mammary tumor" EXACT []
synonym: "decreased susceptibility to mammary tumour" EXACT []
synonym: "increased resistance to mammary neoplasm" EXACT []
synonym: "increased resistance to mammary tumor" EXACT []
synonym: "increased resistance to mammary tumour" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology
is_a: MP:0012416 ! decreased gland tumor incidence
is_a: MP:0012422 ! decreased integument system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:33:31Z

[Term]
id: MP:0010270
name: decreased stomach tumor incidence
alt_id: MP:0003170
def: "less than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased stomach tumour incidence" EXACT []
synonym: "decreased susceptibility to gastric tumor" EXACT []
synonym: "decreased susceptibility to gastric tumour" EXACT []
synonym: "decreased susceptibility to stomach tumor" EXACT []
synonym: "decreased susceptibility to stomach tumour" EXACT []
synonym: "increased resistance to gastric tumor" EXACT []
synonym: "increased resistance to gastric tumour" EXACT []
synonym: "increased resistance to stomach tumor" EXACT []
synonym: "increased resistance to stomach tumour" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0012424 ! decreased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:37:15Z

[Term]
id: MP:0010271
name: decreased tongue tumor incidence
alt_id: MP:0005511
def: "less than the expected number of neoplasms in the tongue tissue, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to tongue neoplasm" EXACT []
synonym: "decreased susceptibility to tongue tumor" EXACT []
synonym: "decreased susceptibility to tongue tumour" EXACT []
synonym: "decreased tongue tumour incidence" EXACT []
synonym: "increased resistance to tongue neoplasm" EXACT []
synonym: "increased resistance to tongue tumor" EXACT []
synonym: "increased resistance to tongue tumour" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
is_a: MP:0012424 ! decreased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:38:38Z

[Term]
id: MP:0010272
name: increased tongue tumor incidence
alt_id: MP:0005509
def: "greater than the expected number of neoplasms in the tongue tissue, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased tongue tumour incidence" EXACT []
synonym: "tongue neoplasm" RELATED []
is_a: MP:0000762 ! abnormal tongue morphology
is_a: MP:0003750 ! increased mouth tumor incidence
is_a: MP:0010292 ! increased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T12:39:51Z

[Term]
id: MP:0010273
name: increased classified tumor incidence
def: "greater than the expected number of tumors with a specific classification type in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased classified tumour incidence" EXACT []
synonym: "increased tumor type incidence" EXACT []
synonym: "increased tumour type incidence" EXACT []
is_a: MP:0002020 ! increased tumor incidence
is_a: MP:0020188 ! abnormal classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T02:32:43Z

[Term]
id: MP:0010274
name: increased organ/body region tumor incidence
def: "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased organ/body region tumour incidence" EXACT []
is_a: MP:0002020 ! increased tumor incidence
is_a: MP:0013152 ! abnormal organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T02:33:47Z

[Term]
id: MP:0010275
name: increased melanoma incidence
def: "greater than the expected number of malignant neoplasms, derived from melanocytes and occurring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8]
is_a: MP:0002018 ! increased malignant tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T02:43:31Z

[Term]
id: MP:0010276
name: increased intraocular melanoma incidence
alt_id: MP:0006247
def: "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the uvea of the eye, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased uvea melanoma incidence" RELATED []
synonym: "increased uveal melanoma incidence" EXACT []
is_a: MP:0010275 ! increased melanoma incidence
is_a: MP:0010302 ! increased uvea tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T02:46:07Z

[Term]
id: MP:0010277
name: increased astrocytoma incidence
def: "greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0010278 ! increased glioma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:06:34Z

[Term]
id: MP:0010278
name: increased glioma incidence
def: "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:08:00Z

[Term]
id: MP:0010279
name: increased gastrointestinal tumor incidence
def: "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased gastrointestinal tract neoplasia incidence" EXACT []
synonym: "increased gastrointestinal tumour incidence" EXACT []
is_a: MP:0010292 ! increased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:18:01Z

[Term]
id: MP:0010280
name: increased skeletal tumor incidence
def: "greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased skeletal tumour incidence" EXACT []
is_a: MP:0005508 ! abnormal skeleton morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:28:52Z

[Term]
id: MP:0010281
name: increased nervous system tumor incidence
def: "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased nervous system tumour incidence" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:37:02Z

[Term]
id: MP:0010282
name: decreased organ/body region tumor incidence
def: "less than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased organ/body region tumour incidence" EXACT []
synonym: "reduced organ/body region tumor incidence" EXACT []
synonym: "reduced organ/body region tumour incidence" EXACT []
is_a: MP:0002052 ! decreased tumor incidence
is_a: MP:0013152 ! abnormal organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:40:31Z

[Term]
id: MP:0010283
name: decreased classified tumor incidence
def: "less than the expected number of tumors with a specific classification type in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased classified tumour incidence" EXACT []
is_a: MP:0002052 ! decreased tumor incidence
is_a: MP:0020188 ! abnormal classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:42:26Z

[Term]
id: MP:0010284
name: decreased plasmacytoma incidence
def: "less han the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased plasma cell lymphoma incidence" EXACT []
synonym: "increased resistance to plasmacytoma" EXACT []
synonym: "plasmacytoma resistance" RELATED []
synonym: "reduced plasmacytoma incidence" EXACT []
is_a: MP:0010268 ! decreased lymphoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:47:13Z

[Term]
id: MP:0010285
name: decreased skin tumor incidence
def: "less than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skin tumour incidence" EXACT []
is_a: MP:0002060 ! abnormal skin morphology
is_a: MP:0012422 ! decreased integument system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T03:50:04Z

[Term]
id: MP:0010286
name: increased plasmacytoma incidence
alt_id: MP:0005233
def: "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased plasma cell lymphoma incidence" EXACT []
synonym: "increased plasmacytoma susceptibility" EXACT []
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T04:09:30Z

[Term]
id: MP:0010287
name: increased reproductive system tumor incidence
def: "greater than the expected number of tumors originating in the reproductive system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased reproductive system tumour incidence" EXACT []
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-03T04:37:41Z

[Term]
id: MP:0010288
name: increased gland tumor incidence
def: "greater than the expected number of tumors originating in a gland in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased gland tumour incidence" EXACT []
is_a: MP:0002163 ! abnormal gland morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T09:38:21Z

[Term]
id: MP:0010289
name: increased urinary system tumor incidence
def: "greater than the expected number of tumors originating in the urinary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased urinary system tumour incidence" EXACT []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T09:41:22Z

[Term]
id: MP:0010290
name: increased muscle tumor incidence
def: "greater than the expected number of tumors originating in muscle tissue in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased muscle tumour incidence" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T09:50:15Z

[Term]
id: MP:0010291
name: increased cardiovascular system tumor incidence
def: "greater than the expected number of tumors originating in the cardiovascular system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cardiovascular system tumour incidence" EXACT []
is_a: MP:0002127 ! abnormal cardiovascular system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T09:55:03Z

[Term]
id: MP:0010292
name: increased alimentary system tumor incidence
def: "greater than the expected number of tumors originating in the alimentary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased alimentary system tumour incidence" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T09:56:49Z

[Term]
id: MP:0010293
name: increased integument system tumor incidence
def: "greater than the expected number of tumors originating in the integument system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased integument system tumour incidence" EXACT []
synonym: "increased integument tumor incidence" EXACT []
synonym: "increased integument tumour incidence" EXACT []
synonym: "increased integumentary system tumor incidence" EXACT []
synonym: "increased integumentary system tumour incidence" EXACT []
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T11:22:45Z

[Term]
id: MP:0010294
name: increased kidney tumor incidence
def: "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased kidney tumour incidence" EXACT []
synonym: "increased renal tumor incidence" EXACT []
synonym: "increased renal tumour incidence" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0010289 ! increased urinary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T11:26:45Z

[Term]
id: MP:0010295
name: increased eye tumor incidence
alt_id: MP:0006178
def: "greater than the expected number of tumors originating in the eye in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased eye tumour incidence" EXACT []
is_a: MP:0002092 ! abnormal eye morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T01:49:09Z

[Term]
id: MP:0010296
name: increased hemolymphoid system tumor incidence
def: "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased haemolymphoid system tumour incidence" EXACT []
synonym: "increased haemolymphoid tumour incidence" EXACT []
synonym: "increased hemolymphoid tumor incidence" EXACT []
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T01:52:10Z

[Term]
id: MP:0010297
name: increased hepatobiliary system tumor incidence
def: "greater than the expected number of tumors originating in the hepatobiliary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased hepatobiliary system tumour incidence" EXACT []
is_a: MP:0002138 ! abnormal hepatobiliary system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T01:54:12Z

[Term]
id: MP:0010298
name: increased respiratory system tumor incidence
def: "greater than the expected number of tumors originating in the respiratory system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased respiratory system tumour incidence" EXACT []
is_a: MP:0002132 ! abnormal respiratory system morphology
is_a: MP:0010274 ! increased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:00:11Z

[Term]
id: MP:0010299
name: increased mammary gland tumor incidence
alt_id: MP:0006318
def: "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mammary gland tumour incidence" EXACT []
synonym: "increased susceptibility to mammary neoplasm" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology
is_a: MP:0010288 ! increased gland tumor incidence
is_a: MP:0010293 ! increased integument system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:12:02Z

[Term]
id: MP:0010300
name: increased skin tumor incidence
alt_id: MP:0005276
def: "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased skin tumour incidence" EXACT []
is_a: MP:0002060 ! abnormal skin morphology
is_a: MP:0010293 ! increased integument system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:14:15Z

[Term]
id: MP:0010301
name: increased stomach tumor incidence
alt_id: MP:0006079
def: "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased gastric tumor incidence" EXACT []
synonym: "increased gastric tumour incidence" EXACT []
synonym: "increased stomach tumour incidence" EXACT []
synonym: "increased susceptibility to gastric tumor" EXACT []
synonym: "increased susceptibility to gastric tumour" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0010279 ! increased gastrointestinal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:16:45Z

[Term]
id: MP:0010302
name: increased uvea tumor incidence
alt_id: MP:0006246
def: "greater than the expected number of neoplasms in the uvea, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased uvea tumour incidence" EXACT []
synonym: "increased uveal tumor incidence" EXACT []
synonym: "increased uveal tumour incidence" EXACT []
synonym: "tumor of uvea" EXACT []
synonym: "tumour of uvea" EXACT []
is_a: MP:0005197 ! abnormal uvea morphology
is_a: MP:0010295 ! increased eye tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:21:01Z

[Term]
id: MP:0010303
name: increased retina tumor incidence
alt_id: MP:0006181
def: "greater than the expected number of neoplasms in the retina, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased retina tumour incidence" EXACT []
synonym: "increased retinal tumor incidence" EXACT []
synonym: "increased retinal tumour incidence" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
is_a: MP:0010295 ! increased eye tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:22:59Z

[Term]
id: MP:0010304
name: increased choroid tumor incidence
alt_id: MP:0006179
def: "greater than the expected number of neoplasms in the choroid of the eye, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased choroid tumour incidence" EXACT []
is_a: MP:0010302 ! increased uvea tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:48:07Z

[Term]
id: MP:0010305
name: increased iris tumor incidence
alt_id: MP:0006231
def: "greater than the expected number of neoplasms in the iris of the eye, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased iris tumour incidence" EXACT []
is_a: MP:0010302 ! increased uvea tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T02:48:26Z

[Term]
id: MP:0010306
name: increased hamartoma incidence
alt_id: MP:0006381
def: "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:07:48Z

[Term]
id: MP:0010307
name: abnormal tumor latency
def: "anomaly in the expected time of onset of tumor occurrence" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal tumour latency" EXACT []
is_a: MP:0002166 ! abnormal tumor susceptibility
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:22:09Z

[Term]
id: MP:0010308
name: decreased tumor latency
def: "earlier onset of tumor occurrence than expected" [https://orcid.org/0000-0003-3691-0324]
synonym: "accelerated tumor appearance" EXACT []
synonym: "accelerated tumour appearance" EXACT []
synonym: "decreased tumour latency" EXACT []
is_a: MP:0010307 ! abnormal tumor latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:31:51Z

[Term]
id: MP:0010309
name: increased mesothelioma incidence
def: "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8]
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:43:38Z

[Term]
id: MP:0010310
name: increased Schwannoma incidence
def: "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8]
synonym: "increased neurilemoma incidence" EXACT []
synonym: "increased neuroschwannoma incidence" EXACT []
synonym: "increased Schwann cell tumor incidence" EXACT []
synonym: "increased Schwann cell tumour incidence" EXACT []
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:48:28Z

[Term]
id: MP:0010311
name: increased meningioma incidence
def: "greater than the expected number of encapsulated neoplasms derived from the meninges, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
comment: Meningiomas may be malignant or benign.
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:55:34Z

[Term]
id: MP:0010312
name: increased oligodendroglioma incidence
def: "greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010278 ! increased glioma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T03:59:02Z

[Term]
id: MP:0010313
name: increased osteoma incidence
def: "greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010280 ! increased skeletal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:06:58Z

[Term]
id: MP:0010314
name: increased neurofibroma incidence
def: "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased fibroneuroma incidence" EXACT []
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:09:33Z

[Term]
id: MP:0010315
name: increased cholangiocarcinoma incidence
def: "greater than the expected number of malignant adenocarcinomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0002928 ! abnormal bile duct morphology
is_a: MP:0010297 ! increased hepatobiliary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:15:41Z

[Term]
id: MP:0010316
name: increased thyroid tumor incidence
def: "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased thyroid tumour incidence" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:45:38Z

[Term]
id: MP:0010317
name: increased parotid gland tumor incidence
def: "greater than the expected number of neoplams in the parotid gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased parotid gland tumour incidence" EXACT []
is_a: MP:0010318 ! increased salivary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:48:31Z

[Term]
id: MP:0010318
name: increased salivary gland tumor incidence
def: "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased salivary gland tumour incidence" EXACT []
is_a: MP:0000613 ! abnormal salivary gland morphology
is_a: MP:0003750 ! increased mouth tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence
is_a: MP:0010292 ! increased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:49:44Z

[Term]
id: MP:0010319
name: increased submandibular gland tumor incidence
def: "greater than the expected number of neoplams in the submandibular gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased submandibular gland tumour incidence" EXACT []
synonym: "increased submaxillary gland tumor incidence" EXACT []
synonym: "increased submaxillary gland tumour incidence" EXACT []
is_a: MP:0010318 ! increased salivary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-04T04:50:30Z

[Term]
id: MP:0010320
name: increased pituitary gland tumor incidence
def: "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pituitary gland tumour incidence" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology
is_a: MP:0010281 ! increased nervous system tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-09T11:09:33Z

[Term]
id: MP:0010321
name: increased parathyroid gland tumor incidence
def: "greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased parathyroid gland tumour incidence" EXACT []
is_a: MP:0000678 ! abnormal parathyroid gland morphology
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-09T11:53:58Z

[Term]
id: MP:0010322
name: increased cutaneous melanoma incidence
def: "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased skin melanoma incidence" EXACT []
is_a: MP:0010275 ! increased melanoma incidence
is_a: MP:0010300 ! increased skin tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-09T12:11:40Z

[Term]
id: MP:0010323
name: retropulsion
alt_id: MP:0005420
def: "a tendency to step or walk backwards" [https://orcid.org/0000-0003-3691-0324]
synonym: "backward walking" EXACT []
synonym: "walking backwards" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-09T03:38:51Z

[Term]
id: MP:0010324
name: abnormal malleus processus brevis morphology
def: "any structural anomaly of the projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding the cartilaginous nodule" [https://orcid.org/0000-0003-3691-0324, PMID:12701100]
synonym: "abnormal malleal processus brevis morphology" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T12:17:58Z

[Term]
id: MP:0010325
name: abnormal malleus head morphology
def: "any structural anomaly of the rounded portion of the malleus articulating with the body of the incus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal caput mallei morphology" EXACT []
synonym: "abnormal head of malleus morphology" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T12:21:18Z

[Term]
id: MP:0010326
name: malleus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the malleus, typically resulting in decreased size" [ISBN:0-683-40008-8]
synonym: "hypoplastic malleus" EXACT []
synonym: "malleal hypoplasia" EXACT []
is_a: MP:0008372 ! small malleus
is_a: MP:0030124 ! middle ear ossicle hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:10:43Z

[Term]
id: MP:0010327
name: abnormal malleus neck morphology
def: "any structural anomaly of the narrow contracted section of the malleus located between the head and the manubrium" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal collum mallei morphology" EXACT []
synonym: "abnormal malleal neck morphology" EXACT []
synonym: "abnormal neck of malleus morphology" EXACT []
is_a: MP:0000029 ! abnormal malleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:12:28Z

[Term]
id: MP:0010328
name: thin malleus neck
def: "smaller diameter of the narrow contracted section of the malleus located between the head and the manubrium" [https://orcid.org/0000-0003-3691-0324]
synonym: "thin collum mallei" EXACT []
synonym: "thin malleal neck" EXACT []
synonym: "thin neck of malleus" EXACT []
is_a: MP:0010327 ! abnormal malleus neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:19:19Z

[Term]
id: MP:0010329
name: abnormal lipoprotein level
def: "any anomaly in the concentrations of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport" [ISBN:0-683-40008-8]
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:40:14Z

[Term]
id: MP:0010330
name: abnormal circulating lipoprotein level
def: "any anomaly in the concentration in the blood of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport" [ISBN:0-683-40008-8]
is_a: MP:0009642 ! abnormal blood homeostasis
is_a: MP:0010329 ! abnormal lipoprotein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:40:33Z

[Term]
id: MP:0010331
name: abnormal apolipoprotein level
def: "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8]
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:41:00Z

[Term]
id: MP:0010332
name: abnormal circulating apolipoprotein level
def: "anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8]
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0010331 ! abnormal apolipoprotein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T01:41:17Z

[Term]
id: MP:0010333
name: abnormal circulating apolipoprotein E level
def: "anomaly in the amount in the blood of a protein that is frequently a component of a VLDL, HDL, and chylomicron complexes, and functions in cholesterol transport" [ISBN:0-683-40008-8]
synonym: "abnormal circulating ApoE level" EXACT []
synonym: "abnormal serum ApoE level" NARROW []
is_a: MP:0010332 ! abnormal circulating apolipoprotein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T02:39:42Z

[Term]
id: MP:0010334
name: pleural effusion
def: "accumulation of excess fluid in the pleural cavity" [https://orcid.org/0000-0003-3691-0324]
synonym: "hydrothorax" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0021205 ! effusion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T03:49:42Z

[Term]
id: MP:0010335
name: fused first pharyngeal arch
def: "the first arch fails to fully divide along the midline" [https://orcid.org/0000-0003-4606-0597]
synonym: "first branchial arch fusion" EXACT []
synonym: "fused first branchial arch" EXACT []
is_a: MP:0006337 ! abnormal first pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T03:56:00Z

[Term]
id: MP:0010336
name: increased acute lymphoblastic leukemia incidence
def: "leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood" [NCIT:C3167]
synonym: "increased acute lymphoblastic leukaemia incidence" EXACT []
synonym: "increased ALL incidence" EXACT []
is_a: MP:0002026 ! increased leukemia incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T04:20:14Z

[Term]
id: MP:0010337
name: increased chronic lymphocytic leukemia incidence
def: "an indolent (slow-growing) cancer in which too many immature lymphocytes (white blood cells) are found mostly in the blood and bone marrow.; in later stages of the disease, cancer cells are sometimes found in the lymph nodes" [NCIT:C3163]
synonym: "increased chronic lymphatic leukaemia incidence" EXACT []
synonym: "increased chronic lymphatic leukemia incidence" EXACT []
synonym: "increased chronic lymphocytic leukaemia incidence" EXACT []
synonym: "increased CLL incidence" EXACT []
is_a: MP:0002026 ! increased leukemia incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-13T04:22:38Z

[Term]
id: MP:0010338
name: increased desmoid tumor incidence
def: "greater than the expected number of a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures in a specific population in a given time period; this connective tissue hyperplasia infiltrates locally, recurs frequently after resection but does not metastasize; this tumor may occur at the site of any fascia, but in particular in muscle" [PMID:18023087]
synonym: "aggressive fibromatosis" RELATED []
synonym: "musculo-aponeurotic fibromatosis" RELATED []
is_a: MP:0003580 ! increased fibroma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T01:30:51Z

[Term]
id: MP:0010339
name: increased cardiac fibroma incidence
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the cardiac tissue, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000266 ! abnormal heart morphology
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0010291 ! increased cardiovascular system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T01:44:36Z

[Term]
id: MP:0010340
name: increased lung fibroma incidence
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the lung, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0008014 ! increased lung tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T01:44:58Z

[Term]
id: MP:0010341
name: increased mammary gland fibroma incidence
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the mammary gland, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0010299 ! increased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T01:45:21Z

[Term]
id: MP:0010342
name: increased facial angiofibroma incidence
def: "greater than the expected number of a benign tumor of fibrous or fully developed connective tissue on the face, in a specific population in a given time period; appear as red or yellow papules containing dilated vascular channels" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased adenoma sebaceum incidence" EXACT []
is_a: MP:0003580 ! increased fibroma incidence
is_a: MP:0008018 ! increased facial tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T01:45:42Z

[Term]
id: MP:0010343
name: increased lipoma incidence
def: "greater than the expected number of a benign neoplasia derived from lipoblasts or lipocytes of white or brown fat, occurring in a specific population in a given time period" [MPATH:417]
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:15:31Z

[Term]
id: MP:0010344
name: increased hibernoma incidence
def: "greater than the expected number of a benign neoplasm derived from brown fat occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased brown adipose tissue tumor incidence" EXACT []
is_a: MP:0010343 ! increased lipoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:21:08Z

[Term]
id: MP:0010345
name: increased thyroid C-cell carcinoma incidence
def: "greater than the expected number of a malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland, occurring in a specific population in a given time period" [MPATH:308]
synonym: "increased C cell thyroid carcinoma incidence" EXACT []
synonym: "increased C-cell thyroid carcinoma incidence" EXACT []
synonym: "increased thyroid C cell carcinoma incidence" EXACT []
synonym: "increased thyroid medullary carcinoma incidence" RELATED []
synonym: "increased thyroid parafollicular carcinoma incidence" EXACT []
synonym: "increased thyroid parafollicular cell carcinoma incidence" EXACT []
is_a: MP:0010346 ! increased thyroid carcinoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:27:47Z

[Term]
id: MP:0010346
name: increased thyroid carcinoma incidence
def: "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0010316 ! increased thyroid tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:39:28Z

[Term]
id: MP:0010347
name: osseous metaplasia
def: "the formation of mature bone elements in the stroma of a neoplasm" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003448 ! abnormal tumor morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:44:14Z

[Term]
id: MP:0010348
name: increased pancreatic islet cell carcinoma incidence
def: "greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0009153 ! increased pancreas tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T03:52:50Z

[Term]
id: MP:0010349
name: increased teratocarcinoma incidence
def: "greater than the expected number of a mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma, occurring in a specific population in a given time period" [MPATH:321]
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0002627 ! increased teratoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:17:08Z

[Term]
id: MP:0010350
name: increased pituitary adenohypophysis tumor incidence
def: "greater than the expected number of neoplasms in the anterior part of the pituitary that secretes a variety of hormones, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pituitary adenohypophysis tumour incidence" EXACT []
synonym: "increased pituitary anterior lobe tumor incidence" EXACT []
synonym: "increased pituitary anterior lobe tumour incidence" EXACT []
is_a: MP:0010320 ! increased pituitary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:30:36Z

[Term]
id: MP:0010351
name: increased pituitary melanotroph tumor incidence
def: "greater than the expected number of neoplasms derived from the cells of intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, https://orcid.org/0000-0003-3691-0324]
synonym: "increased pituitary intermediate lobe tumor incidence" RELATED []
synonym: "increased pituitary intermediate lobe tumour incidence" RELATED []
synonym: "increased pituitary melanotroph tumour incidence" EXACT []
is_a: MP:0010320 ! increased pituitary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:31:02Z

[Term]
id: MP:0010352
name: gastrointestinal tract polyps
def: "abnormal tissue masses that protrude into the lumen of the gastrointestinal tract and are tethered to the wall of the gastrointestinal tract" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000462 ! abnormal digestive system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:42:57Z

[Term]
id: MP:0010353
name: increased odontoma incidence
def: "greater than the expected number of a hamartomatous odontogenic tumor composed of enamel, dentin, cementum, and pulp tissue that may or may not be arranged in the form of a tooth, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:46:28Z

[Term]
id: MP:0010354
name: increased odontosarcoma incidence
def: "greater than the expected number of an a gnathic malignant connective tissue tumor in which the epithelial component is benign and the proliferative mesenchymal component is malignant, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, PMID:10587276]
synonym: "increased ameloblastic fibro-odontosarcoma incidence" EXACT []
synonym: "increased ameloblastic odontosarcoma incidence" EXACT []
synonym: "increased odontogenic sarcoma incidence" EXACT []
is_a: MP:0002032 ! increased sarcoma incidence
is_a: MP:0010353 ! increased odontoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-16T04:50:24Z

[Term]
id: MP:0010355
name: abnormal first pharyngeal arch artery morphology
def: "any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal first aortic arch morphology" EXACT []
synonym: "abnormal first branchial arch artery morphology" EXACT []
synonym: "abnormal first PAA" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006337 ! abnormal first pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-17T11:54:12Z

[Term]
id: MP:0010356
name: abnormal second pharyngeal arch artery morphology
def: "any structural anomaly of the vessels formed within the second pair of branchial arches in embryogenesis" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal second aortic arch morphology" EXACT []
synonym: "abnormal second branchial arch artery morphology" EXACT []
synonym: "abnormal second PAA" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006338 ! abnormal second pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-17T11:54:12Z

[Term]
id: MP:0010357
name: increased prostate gland tumor incidence
alt_id: MP:0003831
def: "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased prostate gland tumour incidence" EXACT []
synonym: "prostate tumor" RELATED []
synonym: "prostate tumour" RELATED []
is_a: MP:0001158 ! abnormal prostate gland morphology
is_a: MP:0010287 ! increased reproductive system tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-17T12:47:29Z

[Term]
id: MP:0010358
name: abnormal free fatty acids level
def: "any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8]
synonym: "abnormal FFA level" EXACT []
synonym: "abnormal free fatty acid level" EXACT []
synonym: "abnormal non-esterified fatty acids level" EXACT []
is_a: MP:0005280 ! abnormal fatty acids level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-18T11:05:18Z

[Term]
id: MP:0010359
name: increased liver free fatty acids level
def: "elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8]
synonym: "increased hepatic free fatty acids level" EXACT []
synonym: "increased liver free fatty acid level" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0005281 ! increased fatty acids level
is_a: MP:0010358 ! abnormal free fatty acids level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-18T11:06:02Z

[Term]
id: MP:0010360
name: decreased liver free fatty acids level
def: "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8]
synonym: "decreased hepatic free fatty acids level" EXACT []
synonym: "decreased liver free fatty acid level" EXACT []
synonym: "reduced hepatic free fatty acids level" EXACT []
synonym: "reduced liver free fatty acids level" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0005282 ! decreased fatty acids level
is_a: MP:0010358 ! abnormal free fatty acids level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-18T11:06:34Z

[Term]
id: MP:0010361
name: increased gangliosarcoma incidence
def: "greater than the expected number of a highly aggressive malignant neoplasm arising from mature ganglionic neurons, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased ganglioneurosarcoma incidence" EXACT []
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-19T10:10:15Z

[Term]
id: MP:0010362
name: increased ganglioneuroma incidence
def: "greater than the expected number of a benign neoplasm composed of mature ganglionic neurons in a given population in a given time period; cells may be scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers" [MPATH:375]
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-19T10:11:35Z

[Term]
id: MP:0010363
name: increased fibrosarcoma incidence
alt_id: MP:0002029
def: "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased fibroblastic sarcoma incidence" EXACT []
is_a: MP:0002032 ! increased sarcoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-19T10:31:47Z

[Term]
id: MP:0010364
name: increased fibroadenoma incidence
alt_id: MP:0003343
def: "greater than the expected number of a benign mammary gland tumor composed of both fibrous tissue and glandular tissue, in a specific population in a given time period" [CDR:523438]
synonym: "increased breast fibroadenoma incidence" EXACT []
synonym: "increased mammary gland fibroadenoma incidence" EXACT []
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010299 ! increased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-19T10:45:18Z

[Term]
id: MP:0010365
name: increased thymus tumor incidence
def: "greater than the expected number of neoplams in the thymus occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased thymic tumor incidence" EXACT []
synonym: "increased thymic tumour incidence" EXACT []
synonym: "increased thymus tumour incidence" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-26T03:38:42Z

[Term]
id: MP:0010366
name: increased adrenal cortical tumor incidence
def: "greater than the expected number of neoplams in the adrenal cortex occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased adrenal cortical tumour incidence" EXACT []
is_a: MP:0002031 ! increased adrenal gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-26T03:42:09Z

[Term]
id: MP:0010367
name: increased spindle cell carcinoma incidence
def: "greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]
synonym: "increased pseudosarcoma incidence" EXACT []
synonym: "increased sarcomatoid carcinoma incidence" EXACT []
synonym: "increased SpCC incidence" EXACT []
is_a: MP:0002038 ! increased carcinoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-26T03:54:01Z

[Term]
id: MP:0010368
name: abnormal lymphatic system physiology
def: "any functional anomaly of the interconnected system of spaces, organs and vessels between body tissues and organs through which fluid, fats, proteins, and lymphocytes are transported to the bloodstream as lymph, and microorganisms and other debris are removed from tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lymph system physiology" EXACT []
synonym: "abnormal lymphoid system physiology" EXACT []
is_a: MP:0001790 ! abnormal immune system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T09:42:10Z

[Term]
id: MP:0010369
name: abnormal thalamus neuron morphology
def: "any structural anomaly of the impulse-conducting cells in the thalamus or its parts, a midline paired symmetrical structure between the cerebral cortex and midbrain within the brain that controls the flow of information to the cortex" [https://orcid.org/0000-0003-3691-0324, MGI:llw2]
synonym: "abnormal thalamic neuron morphology" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T12:34:11Z

[Term]
id: MP:0010370
name: abnormal throat morphology
def: "any structural anomaly in the anterior part of the neck, in front of the vertebral column comprising the pharynx and larynx" [MGI:llw2]
synonym: "abnormal fauces morphology" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T12:38:50Z

[Term]
id: MP:0010371
name: abnormal epiglottis morphology
alt_id: MP:0002259
def: "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MGI:llw2]
is_a: MP:0002256 ! abnormal laryngeal cartilage morphology
is_a: MP:0010370 ! abnormal throat morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T12:39:55Z

[Term]
id: MP:0010372
name: throat cyst
def: "presence of one or more fluid-filled, usually benign, growths in the passage from the mouth to the pharynx" [MGI:llw2]
synonym: "cystic throat" EXACT []
synonym: "throat cysts" EXACT []
is_a: MP:0010370 ! abnormal throat morphology
is_a: MP:0031310 ! abnormal cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T12:40:34Z

[Term]
id: MP:0010373
name: myeloid hyperplasia
def: "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced myelopoesis" RELATED []
is_a: MP:0001601 ! abnormal myelopoiesis
is_a: MP:0013663 ! increased myeloid cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T12:59:47Z

[Term]
id: MP:0010374
name: bilirubinate stones
def: "caliculi in the gallbladder or a bile duct that is composed of calcium bilirubinate" [https://orcid.org/0000-0003-3691-0324]
synonym: "black stones" EXACT []
synonym: "calcium bilirubinate stones" EXACT []
synonym: "pigment stones" EXACT []
is_a: MP:0002830 ! gallstones
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T01:03:46Z

[Term]
id: MP:0010375
name: increased kidney iron level
def: "increase in the amount of iron present in the renal tissue" [MGI:llw2]
synonym: "increased renal iron level" EXACT []
synonym: "kidney iron deposits" EXACT []
synonym: "renal iron deposits" EXACT []
is_a: MP:0008742 ! abnormal kidney iron level
is_a: MP:0014541 ! increased iron level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T01:28:09Z

[Term]
id: MP:0010376
name: decreased kidney iron level
def: "reduction in the amount of iron present in the renal tissue" [MGI:llw2]
synonym: "decreased renal iron level" EXACT []
synonym: "reduced kidney iron level" EXACT []
synonym: "reduced renal iron level" EXACT []
is_a: MP:0008742 ! abnormal kidney iron level
is_a: MP:0014542 ! decreased iron level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T01:28:25Z

[Term]
id: MP:0010377
name: abnormal gut flora balance
def: "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001663 ! abnormal digestive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-08-27T04:00:05Z

[Term]
id: MP:0010378
name: increased respiratory quotient
def: "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "increased respiratory exchange ratio" EXACT []
synonym: "increased RQ" EXACT []
is_a: MP:0004129 ! abnormal respiratory quotient
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-16T02:01:33Z

[Term]
id: MP:0010379
name: decreased respiratory quotient
def: "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased respiratory exchange ratio" EXACT []
synonym: "decreased RQ" EXACT []
synonym: "reduced respiratory exchange ratio" EXACT []
synonym: "reduced RQ" EXACT []
is_a: MP:0004129 ! abnormal respiratory quotient
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-16T02:01:46Z

[Term]
id: MP:0010380
name: abnormal inner cell mass apoptosis
def: "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0013503 ! abnormal embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-16T04:06:47Z

[Term]
id: MP:0010381
name: abnormal dosage compensation
def: "anomaly in the process of compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes" [GO:0007549]
is_a: MP:0012167 ! abnormal epigenetic regulation of gene expression
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T10:01:32Z

[Term]
id: MP:0010382
name: abnormal dosage compensation, by inactivation of X chromosome
def: "anomaly in the process of compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex" [GO:0009048]
synonym: "abnormal Barr body formation" EXACT []
synonym: "abnormal X chromosome inactivation" EXACT []
is_a: MP:0010381 ! abnormal dosage compensation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T10:03:17Z

[Term]
id: MP:0010383
name: increased adenoma incidence
alt_id: MP:0002815
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8, MESH:C04.557.470.035]
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0020189 ! abnormal adenoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T02:43:52Z

[Term]
id: MP:0010384
name: increased renal carcinoma incidence
alt_id: MP:0002046
def: "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased kidney carcinoma incidence" EXACT []
is_a: MP:0002038 ! increased carcinoma incidence
is_a: MP:0010294 ! increased kidney tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T02:48:36Z

[Term]
id: MP:0010385
name: abnormal glycinergic neuron morphology
def: "any structural anomaly of the neurons that utilize glycine as a neurotransmitter" [ISBN:0838580343]
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T03:27:41Z

[Term]
id: MP:0010386
name: abnormal urinary bladder physiology
alt_id: MP:0005303
def: "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8]
synonym: "functional abnormality of the bladder" EXACT []
synonym: "urinary bladder dysfunction" EXACT []
is_a: MP:0005502 ! abnormal renal/urinary system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T03:36:07Z

[Term]
id: MP:0010387
name: abnormal Bergmann glial cell morphology
def: "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal Bergmann glia" EXACT []
is_a: MP:0000875 ! abnormal cerebellar Purkinje cell layer
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T03:55:18Z

[Term]
id: MP:0010388
name: abnormal Bergmann glial cell differentiation
def: "abnormal formation of the astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8]
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0010387 ! abnormal Bergmann glial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T03:56:52Z

[Term]
id: MP:0010389
name: mosaic coat color
def: "a random coat color pattern due to genetically different populations of cells in the skin e.g. as the result of X-inactivation" [MGI:llw2]
comment: In the vocabulary of mouse coat color geneticists, "mosaic" is a special-case patterning; only some cases of variegated coat color are mosaic.
synonym: "mosaic coat colour" EXACT []
is_a: MP:0005366 ! variegated coat color
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-20T04:12:23Z

[Term]
id: MP:0010390
name: increased adrenocortical adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the adrenal cortex, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased adrenal cortex adenoma incidence" EXACT []
synonym: "increased adrenal cortical adenoma incidence" EXACT []
is_a: MP:0009044 ! increased adrenal gland adenoma incidence
is_a: MP:0010366 ! increased adrenal cortical tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-21T11:09:18Z

[Term]
id: MP:0010391
name: increased rhabdomyoma incidence
alt_id: MP:0006139
def: "greater than the expected number of a benign neoplasm derived from striated muscle and comprised of an encapsulated mass of polygonal cells, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010290 ! increased muscle tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-21T12:39:56Z

[Term]
id: MP:0010392
name: prolonged QRS complex duration
def: "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "prolonged QRS duration" EXACT []
synonym: "prolonged QRS interval" EXACT []
synonym: "QRS interval elongation" EXACT []
synonym: "widened QRS complex" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
is_a: MP:0010636 ! bundle branch block
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T12:42:32Z

[Term]
id: MP:0010393
name: shortened QRS complex duration
def: "decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "narrow QRS complex" EXACT []
synonym: "shortened QRS duration" EXACT []
synonym: "shortened QRS interval" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T02:37:21Z

[Term]
id: MP:0010394
name: decreased QRS amplitude
def: "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced QRS amplitude" RELATED []
synonym: "reduced R wave amplitude" NARROW []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T02:39:35Z

[Term]
id: MP:0010395
name: abnormal pharyngeal arch development
def: "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2]
synonym: "abnormal branchial arch development" EXACT []
is_a: MP:0001672 ! abnormal embryo development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T03:33:41Z

[Term]
id: MP:0010396
name: ectopic pharyngeal arch
def: "abnormal location of any of the transient structures of the embryo resulting in misplaced regions of the head, neck and/or ears" [MGI:llw2]
synonym: "ectopic branchial arch" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T03:35:03Z

[Term]
id: MP:0010397
name: abnormal otic capsule development
def: "any anomaly in the embryonic cartilage covering that surrounds the inner ear mechanism and develops into bone" [MGI:llw2]
synonym: "abnormal auditory capsule development" EXACT []
is_a: MP:0000039 ! abnormal otic capsule morphology
is_a: MP:0006030 ! abnormal otic vesicle development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T03:40:07Z

[Term]
id: MP:0010398
name: decreased liver glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hepatic glycogen level" EXACT []
synonym: "reduced hepatic glycogen level" EXACT []
synonym: "reduced liver glycogen level" RELATED []
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0012777 ! abnormal liver glycogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T03:56:01Z

[Term]
id: MP:0010399
name: decreased skeletal muscle glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased striated muscle glycogen level" EXACT []
synonym: "reduced skeletal muscle glycogen level" EXACT []
synonym: "reduced striated muscle glycogen level" EXACT []
is_a: MP:0014069 ! abnormal skeletal muscle glycogen level
is_a: MP:0031615 ! decreased muscle glycogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T03:58:07Z

[Term]
id: MP:0010400
name: increased liver glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased hepatic glycogen level" EXACT []
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0012777 ! abnormal liver glycogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T04:00:20Z

[Term]
id: MP:0010401
name: increased skeletal muscle glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased striated muscle glycogen level" EXACT []
is_a: MP:0014069 ! abnormal skeletal muscle glycogen level
is_a: MP:0031616 ! increased muscle glycogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-22T04:00:40Z

[Term]
id: MP:0010402
name: ventricular septal defect
def: "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
comment: The term name is common usage among cardiologists and refers to the specific state in the definition (abnormal communications); do not confuse with parent term.
subset: CvDC_Terms
synonym: "interventricular septal defect" EXACT []
synonym: "ventricular septum foramen" EXACT []
synonym: "VSD" EXACT []
xref: Fyler:1300
is_a: MP:0000281 ! abnormal interventricular septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-24T03:08:25Z

[Term]
id: MP:0010403
name: atrial septal defect
def: "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
comment: The term name is common usage among cardiologists and refers to the specific state in the definition (abnormal communications); do not confuse with parent term.
subset: CvDC_Terms
synonym: "ASD" EXACT []
synonym: "atrial septum foramen" EXACT []
synonym: "interatrial septal defect" EXACT []
xref: Fyler:2050
is_a: MP:0000282 ! abnormal interatrial septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-24T03:16:37Z

[Term]
id: MP:0010404
name: ostium primum atrial septal defect
def: "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "ostium primum ASD" EXACT []
synonym: "primum ASD" EXACT []
synonym: "primum atrial septal defect" EXACT []
xref: Fyler:1110
is_a: MP:0010403 ! atrial septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T10:21:21Z

[Term]
id: MP:0010405
name: ostium secundum atrial septal defect
def: "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "ostium secundum ASD" EXACT []
synonym: "secundum ASD" EXACT []
synonym: "secundum atrial septal defect" EXACT []
xref: Fyler:2000
is_a: MP:0010403 ! atrial septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T10:21:42Z

[Term]
id: MP:0010406
name: common atrium
def: "absence of the thin membranous structure between the two heart atria, resulting in the appearance of one upper chamber" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "absent atrial septum" EXACT []
synonym: "absent atrium septum" EXACT []
synonym: "absent interatrial septal wall" EXACT []
synonym: "absent interatrial septum" EXACT []
synonym: "common atrium ASD" EXACT []
synonym: "single atrium ASD" EXACT []
synonym: "single atrium atrial septal defect" EXACT []
xref: Fyler:1140
is_a: MP:0010403 ! atrial septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T10:22:18Z

[Term]
id: MP:0010407
name: coronary sinus atrial septal defect
def: "interatrial communication (atrial septal defect) through coronary sinus orifice, that is characterized by the absence of at least a portion of the common wall that separates the coronary sinus and the left atrium; interatrial shunting occurs through the defect in the wall on the left atrial side, which is continuous with the orifice of the coronary sinus opening on the right atrial side of the septum" [http://emedicine.medscape.com, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "coronary sinus ASD" EXACT []
is_a: MP:0010403 ! atrial septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T10:22:34Z

[Term]
id: MP:0010408
name: sinus venosus atrial septal defect
def: "interatrial communication (atrial septal defect) through the upper atrial septum and that is contiguous with the superior vena cava (SVC); it is rostral and posterior to the fossa ovalis (where secundum type defects occur) and is separate from it" [http://emedicine.medscape.com, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "sinus venosum ASD" EXACT []
synonym: "sinus venosus ASD" EXACT []
xref: Fyler:2010
is_a: MP:0010403 ! atrial septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T11:20:28Z

[Term]
id: MP:0010409
name: cor triatriatum
def: "a heart with 3 atria, is in which either the left or right atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band that may vary significantly in size and shape, appearing similar to a diaphragm or funnel-shaped, bandlike, entirely intact (imperforate) or contain 1 or more openings (fenestrations) ranging from small, restrictive-type to large and widely open" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "triatrial heart" EXACT []
xref: Fyler:3031
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T12:39:50Z

[Term]
id: MP:0010410
name: cor triatriatum sinistrum
def: "a heart with 3 atria, is in which the left atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band" [http://emedicine.medscape.com]
subset: CvDC_Terms
is_a: MP:0003923 ! abnormal heart left atrium morphology
is_a: MP:0010409 ! cor triatriatum
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T12:40:08Z

[Term]
id: MP:0010411
name: cor triatriatum dextrum
def: "a heart with 3 atria, is in which the right atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "cor triatriatum dextra" EXACT []
xref: Fyler:2854
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0010409 ! cor triatriatum
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T12:40:27Z

[Term]
id: MP:0010412
name: atrioventricular septal defect
def: "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
comment: The term name is common usage among cardiologists and refers to the specific state in the definition (abnormal communications); do not confuse with parent term.
subset: CvDC_Terms
synonym: "Atrioventricular canal (endocardial cushion defect)" EXACT []
synonym: "atrioventricular canal defect" EXACT []
synonym: "AV septal defect" EXACT []
synonym: "AVC" EXACT []
synonym: "AVCD" EXACT []
synonym: "AVSD" EXACT []
synonym: "ECD" EXACT []
synonym: "endocardial cushion defect" EXACT []
xref: Fyler:1100
is_a: MP:0010592 ! abnormal atrioventricular septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T02:50:46Z

[Term]
id: MP:0010413
name: complete atrioventricular septal defect
def: "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "common atrioventricular canal" EXACT []
synonym: "complete atrioventricular canal defect" EXACT []
synonym: "complete AVC" EXACT []
synonym: "complete AVSD" EXACT []
synonym: "complete common atrioventricular canal" EXACT []
synonym: "complete common AV canal" EXACT []
synonym: "complete ECD" EXACT []
synonym: "complete endocardial cushion defect" EXACT []
xref: Fyler:1120
is_a: MP:0010412 ! atrioventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T03:17:33Z

[Term]
id: MP:0010414
name: partial atrioventricular septal defect
def: "a type of atrioventricular septal defect in which the endocardial cushion defects present have an interatrial communication but lack an interventricular communication; the mitral and tricuspid annuli are separate but one or more additional features are present, including primum atrial septal defect (ASD), inlet ventricular septal defect (VSD), cleft of the anterior mitral valve leaflet, and wide anteroseptal tricuspid valve commissure or cleft septal tricuspid leaflet" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "partial atrioventricular canal defect" EXACT []
synonym: "partial AVC" EXACT []
synonym: "partial AVSD" EXACT []
synonym: "partial common atrioventricular canal" EXACT []
synonym: "partial ECD" EXACT []
synonym: "partial endocardial cushion defect" EXACT []
is_a: MP:0010412 ! atrioventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T03:18:02Z

[Term]
id: MP:0010415
name: intermediate atrioventricular septal defect
def: "a type of atrioventricular septal defect in which a partial AVSD is present together with a small interventricular communication; a single valvar annulus is usually present where the anterior and posterior bridging leaflets fuse overlying the ventricular septum, with two distinct valvar components observed" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "intermediate atrioventricular canal defect" EXACT []
synonym: "intermediate AVC" EXACT []
synonym: "intermediate AVSD" EXACT []
synonym: "intermediate ECD" EXACT []
synonym: "intermediate endocardial cushion defect" EXACT []
synonym: "transitional common atrioventricular canal" EXACT []
xref: Fyler:1121
is_a: MP:0010412 ! atrioventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T03:29:50Z

[Term]
id: MP:0010416
name: interventricular septum membranous part aneurysm
def: "a a saclike thinning, stretching and widening of the ventricular membranous septum resulting from weakening of the membraneous septum wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "aneurysm of membranous septum" EXACT []
synonym: "ventricular membranous septum aneurysm" EXACT []
xref: Fyler:2346
is_a: MP:0008823 ! abnormal interventricular septum membranous part morphology
is_a: MP:0010421 ! ventricular aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T03:54:46Z

[Term]
id: MP:0010417
name: subarterial ventricular septal defect
def: "abnormal communications between the two lower chambers of the heart, located beneath the pulmonic valve, communicating with the RV outflow tract above the supraventricular crest, and are associated with aortic regurgitation secondary to the prolapse of the right aortic cusp" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "conal septal defect" EXACT []
synonym: "conal septal ventricular septal defect" EXACT []
synonym: "conus ventricular septal defect" EXACT []
synonym: "infundibular ventricular septal defect" EXACT []
synonym: "outlet ventricular septal defect" EXACT []
synonym: "subarterial doubly committed ventricular septal defect" EXACT []
synonym: "subpulmonic ventricular septal defect" EXACT []
synonym: "supracristal ventricular septal defect" EXACT []
synonym: "VSD, Type 1" EXACT []
xref: Fyler:1330
is_a: MP:0010402 ! ventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T04:09:31Z

[Term]
id: MP:0010418
name: perimembraneous ventricular septal defect
def: "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "conoventricular ventricular septal defect" EXACT []
synonym: "high ventricular septal defect" EXACT []
synonym: "infracristal ventricular septal defect" EXACT []
synonym: "membraneous ventricular septal defect" RELATED []
synonym: "paramembranous ventricular septal defect" EXACT []
synonym: "perimembranous inlet ventricular septal defect" NARROW []
synonym: "perimembranous muscular ventricular septal defect" NARROW []
synonym: "perimembranous outlet ventricular septal defect" NARROW []
synonym: "pmVSD" EXACT []
synonym: "ventricular septal defect, membranous" EXACT []
synonym: "VSD, Type 2" EXACT []
xref: Fyler:1310
is_a: MP:0008823 ! abnormal interventricular septum membranous part morphology
is_a: MP:0010402 ! ventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T04:12:45Z

[Term]
id: MP:0010419
name: inlet ventricular septal defect
def: "abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "AV Canal type VSD" EXACT []
synonym: "AV septum-type ventricular septum defect" EXACT []
synonym: "canal-type ventricular septal defect" EXACT []
synonym: "endocardial cushion-type ventricular septal defect" EXACT []
synonym: "inlet-type ventricular septal defect" EXACT []
synonym: "juxtatricuspid ventricular septal defect" EXACT []
synonym: "posterior ventricular septal defect" EXACT []
synonym: "Ventricular septal defect, ECD type" EXACT []
synonym: "VSD, Type 3" EXACT []
xref: Fyler:1340
is_a: MP:0010402 ! ventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T04:13:10Z

[Term]
id: MP:0010420
name: muscular ventricular septal defect
def: "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "mVSD" EXACT []
synonym: "Swiss-cheese septum" EXACT []
synonym: "trabecular ventricular septal defect" EXACT []
synonym: "ventricular septal defect, muscular" EXACT []
synonym: "VSD, Type 4" EXACT []
xref: Fyler:1320
is_a: MP:0010402 ! ventricular septal defect
is_a: MP:0010498 ! abnormal interventricular septum muscular part morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-27T04:13:52Z

[Term]
id: MP:0010421
name: ventricular aneurysm
def: "thinning, stretching and bulging of a weakened ventricular wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "cardiac aneurysm" EXACT []
synonym: "mural aneurysm" EXACT []
is_a: MP:0003279 ! aneurysm
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T11:25:43Z

[Term]
id: MP:0010422
name: heart right ventricle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart right ventricle, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic RV" EXACT []
synonym: "right ventricular hypoplasia" EXACT []
xref: Fyler:1821
is_a: MP:0000279 ! ventricular hypoplasia
is_a: MP:0003649 ! decreased heart right ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T11:33:10Z

[Term]
id: MP:0010423
name: heart right ventricle aneurysm
def: "thinning, stretching and bulging of a weakened heart right ventricular wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:2333
is_a: MP:0010421 ! ventricular aneurysm
is_a: MP:0031534 ! abnormal heart right ventricle wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T11:44:38Z

[Term]
id: MP:0010424
name: double chambered heart right ventricle
def: "septated right ventricle caused by the presence of abnormally located or hypertrophied cardiac muscle bands that divide the ventricular cavity into a proximal and a distal chamber; the muscle bundles typically run between an area located in the ventricular septum, beneath the level of the septal leaflet of the tricuspid valve, and the anterior wall of the right ventricle" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "DCRV" EXACT []
synonym: "double chambered right ventricle" EXACT []
synonym: "double chambered RV" EXACT []
synonym: "Double-Chambered Right Ventricle" EXACT []
synonym: "septated right ventricle" BROAD []
is_a: MP:0003920 ! abnormal heart right ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T11:47:43Z

[Term]
id: MP:0010425
name: abnormal heart and great vessel attachment
def: "any anomaly in the in the position or pattern of the connection site of the heart to any of the primary vessels, including the superior vena cavae, inferior vena cavae, pulmonary artery, pulmonary veins, and aorta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T12:37:59Z

[Term]
id: MP:0010426
name: abnormal heart and great artery attachment
def: "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010425 ! abnormal heart and great vessel attachment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T12:45:42Z

[Term]
id: MP:0010427
name: double outlet left ventricle
def: "both the aorta and the pulmonary trunk originate from the left ventricle" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "DOLV" EXACT []
synonym: "double outlet heart left ventricle" EXACT []
xref: Fyler:0650
xref: Fyler:650
is_a: MP:0010426 ! abnormal heart and great artery attachment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T12:52:51Z

[Term]
id: MP:0010428
name: abnormal heart right ventricle outflow tract morphology
alt_id: MP:0009464
def: "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal arterial cone morphology" EXACT []
synonym: "abnormal conus arteriosus morphology" EXACT []
synonym: "abnormal infundibulum of right ventricle" EXACT []
synonym: "abnormal infundibulum of the heart" EXACT []
synonym: "abnormal pulmonary cone morphology" EXACT []
synonym: "abnormal pulmonary conus" EXACT []
synonym: "abnormal right ventricle pulmonary outflow tract" EXACT []
synonym: "abnormal RVOT" EXACT []
is_a: MP:0003920 ! abnormal heart right ventricle morphology
is_a: MP:0010224 ! abnormal heart ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T01:22:48Z

[Term]
id: MP:0010429
name: abnormal heart left ventricle outflow tract morphology
def: "any structural anomaly of the anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal aortic vestibule morphology" EXACT []
synonym: "abnormal left ventricular outflow region morphology" EXACT []
synonym: "abnormal LVOT" EXACT []
synonym: "abnormal outflow part of left ventricle morphology" RELATED []
synonym: "abnormal outflow tract of left ventricle morphology" EXACT []
synonym: "abnormal Sibson vestibule" EXACT []
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0010224 ! abnormal heart ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T01:23:35Z

[Term]
id: MP:0010430
name: total anomalous pulmonary venous connection, supracardiac
def: "the pulmonary veins drain via a common vein into the right superior vena cava, left superior vena cava, or their tributaries instead of the left atrium" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "TAPVC, Type 1 (supracardiac)" EXACT []
synonym: "totally anomalous pulmonary venous return, supracardiac" EXACT []
xref: Fyler:0910
xref: Fyler:910
is_a: MP:0010441 ! total anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:41:50Z

[Term]
id: MP:0010431
name: atrial situs inversus
def: "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the opposite side of the body" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "inverted atria" EXACT []
xref: Fyler:0150
xref: Fyler:150
is_a: MP:0004133 ! heterotaxia
is_a: MP:0006065 ! abnormal heart position or orientation
is_a: MP:0014319 ! abnormal heart atrium arrangement
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T01:50:46Z

[Term]
id: MP:0010432
name: common ventricle
def: "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "absent interventricular septum" RELATED []
synonym: "single ventricle" EXACT []
synonym: "univentricular heart" EXACT []
xref: Fyler:0200
xref: Fyler:200
is_a: MP:0000281 ! abnormal interventricular septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T01:54:56Z

[Term]
id: MP:0010433
name: double inlet heart left ventricle
alt_id: MP:0005295
def: "congenital heart defect in which both atriums are connected to the left ventricle, with a hypoplastic right ventricle often present, which may be on the opposite side of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "DILV" EXACT []
synonym: "double inlet left ventricle" EXACT []
is_a: MP:0010435 ! abnormal heart atrium and ventricle connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:00:04Z

[Term]
id: MP:0010434
name: double inlet heart right ventricle
def: "congenital heart defect in which both atriums are connected to the right ventricle, with a hypoplastic left ventricle often present" [PMID:7008335]
subset: CvDC_Terms
synonym: "DIRV" EXACT []
synonym: "double inlet right ventricle" EXACT []
is_a: MP:0010435 ! abnormal heart atrium and ventricle connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:00:44Z

[Term]
id: MP:0010435
name: abnormal heart atrium and ventricle connection
def: "any anomaly in the in the position or pattern of the connection site of the heart atrium to the ventricles, usually occurring through the atrioventricular valves" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal atrioventricular connection" EXACT []
synonym: "abnormal AV connections" EXACT []
synonym: "abnormal VA connections" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:13:14Z

[Term]
id: MP:0010436
name: abnormal coronary sinus morphology
def: "any structural anomaly of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal sinus coronarius morphology" EXACT []
xref: Fyler:2840
is_a: MP:0010551 ! abnormal coronary vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:33:34Z

[Term]
id: MP:0010437
name: absent coronary sinus
def: "absence of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "absent sinus coronarius" EXACT []
xref: Fyler:2841
is_a: MP:0010436 ! abnormal coronary sinus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:37:37Z

[Term]
id: MP:0010438
name: pulmonary vein stenosis
def: "abnormal narrowing or constriction of the lumen of the pulmonary vein" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "pulmonary vein stricture" EXACT []
synonym: "pulmonary venous obstruction" RELATED []
xref: Fyler:3002
is_a: MP:0002726 ! abnormal pulmonary vein morphology
is_a: MP:0031477 ! vein stenosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:41:28Z

[Term]
id: MP:0010439
name: abnormal hepatic vein morphology
def: "any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions" [ISBN:0-683-40008-8]
subset: CvDC_Terms
is_a: MP:0002725 ! abnormal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T02:54:04Z

[Term]
id: MP:0010440
name: anomalous pulmonary venous connection
def: "abnormal development and attachment of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in either partial or complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery" [http://emedicine.medscape.com]
comment: The word "anomalous" in this term and its children was used instead of abnormal since this is common usage among cardiologists.
subset: CvDC_Terms
synonym: "abnormal lung vein connection" EXACT []
synonym: "abnormal pulmonary vein connection" EXACT []
synonym: "anomalous pulmonary venous return" RELATED []
synonym: "APVC" EXACT []
is_a: MP:0010425 ! abnormal heart and great vessel attachment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:01:06Z

[Term]
id: MP:0010441
name: total anomalous pulmonary venous connection
def: "abnormal development and attachment of all four pulmonary veins that normally attach to the left atrium of the heart, resulting in complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery; in TAPVC, none of the four pulmonary veins are attached to the left atrium" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "TAPVC" EXACT []
synonym: "TAPVD" EXACT []
synonym: "TAPVR" EXACT []
synonym: "total anomalous pulmonary venous drainage" EXACT []
synonym: "total anomalous pulmonary venous return" EXACT []
synonym: "totally anomalous pulmonary venous return" EXACT []
xref: Fyler:0900
xref: Fyler:900
is_a: MP:0010440 ! anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:01:58Z

[Term]
id: MP:0010442
name: partial anomalous pulmonary venous connection
def: "abnormal development and attachment of one to three of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in partial drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery; in PAPVC, at least one pulmonary vein remains attached to the left atrium" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "PAPVC" EXACT []
synonym: "PAPVR" EXACT []
synonym: "partial anomalous pulmonary venous return" EXACT []
synonym: "partially anomalous pulmonary venous connection(s)" EXACT []
xref: Fyler:2030
is_a: MP:0010440 ! anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:05:45Z

[Term]
id: MP:0010443
name: total anomalous pulmonary venous connection, intracardiac
def: "the pulmonary veins connect directly to the right side of heart (eg, coronary sinus or directly to the right atrium) instead of the left atrium" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "TAPVC, Type 2 (cardiac)" EXACT []
synonym: "totally anomalous pulmonary venous return, coronary sinus" NARROW []
synonym: "totally anomalous pulmonary venous return, right atrium" NARROW []
xref: Fyler:0920
xref: Fyler:0930
xref: Fyler:920
xref: Fyler:930
is_a: MP:0010441 ! total anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:42:16Z

[Term]
id: MP:0010444
name: total anomalous pulmonary venous connection, infracardiac
def: "the common pulmonary vein travels down anterior to the esophagus through the diaphragm to connect to the portal venous system instead of the left atrium" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "TAPVC, infradiaphragmatic connection" EXACT []
synonym: "TAPVC, Type 3 (infracardiac)" EXACT []
synonym: "totally anomalous pulmonary venous return, infradiaphragmatic" EXACT []
is_a: MP:0010441 ! total anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:42:33Z

[Term]
id: MP:0010445
name: total anomalous pulmonary venous connection, mixed
def: "the right and left pulmonary veins drain to different sites other than the left atrium; for example, the left pulmonary veins into the left vertical vein to the left innominate, and/or the right pulmonary veins directly into the right atrium or coronary sinus" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "TAPVC, Type 4 (mixed)" EXACT []
xref: Fyler:0950
xref: Fyler:950
is_a: MP:0010441 ! total anomalous pulmonary venous connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T03:42:53Z

[Term]
id: MP:0010446
name: heart left ventricle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart left ventricle, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic heart left ventricle" EXACT []
synonym: "hypoplastic LV" EXACT []
synonym: "LV hypoplasia" EXACT []
xref: Fyler:1811
is_a: MP:0000279 ! ventricular hypoplasia
is_a: MP:0010580 ! decreased heart left ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T04:13:22Z

[Term]
id: MP:0010447
name: heart left ventricle aneurysm
def: "thinning, stretching and bulging of a weakened heart left ventricular wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "LV aneurysm" EXACT []
xref: Fyler:2340
is_a: MP:0010421 ! ventricular aneurysm
is_a: MP:0031533 ! abnormal heart left ventricle wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T04:14:22Z

[Term]
id: MP:0010448
name: heart left ventricle outflow tract stenosis
def: "abnormal narrowing or constriction of the portion of the left ventricle through which blood normally flows into the aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "aortic vestibule stenosis" EXACT []
synonym: "heart left ventricle outflow tract obstruction" EXACT []
synonym: "left ventricular outflow region stenosis" EXACT []
synonym: "LVOTO" EXACT []
synonym: "outflow part of left ventricle stenosis" EXACT []
synonym: "outflow tract of left ventricle stenosis" EXACT []
synonym: "subaortic stenosis" NARROW []
synonym: "subvalvar stenosis" RELATED []
xref: Fyler:1470
is_a: MP:0010429 ! abnormal heart left ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T04:20:54Z

[Term]
id: MP:0010449
name: heart right ventricle outflow tract stenosis
alt_id: MP:0010518
def: "abnormal narrowing or constriction of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "arterial cone stenosis" EXACT []
synonym: "conus arteriosus stenosis" EXACT []
synonym: "heart right ventricle outflow tract obstruction" EXACT []
synonym: "infundibular pulmonary stenosis" EXACT []
synonym: "infundibular pulmonic stenosis" EXACT []
synonym: "infundibulum of right ventricle stenosis" EXACT []
synonym: "infundibulum of the heart stenosis" EXACT []
synonym: "pulmonary cone stenosis" EXACT []
synonym: "pulmonary conus stenosis" EXACT []
synonym: "right ventricle infundibulum stenosis" RELATED []
synonym: "right ventricle pulmonary outflow tract stenosis" EXACT []
synonym: "RVOTO" EXACT []
synonym: "subpulmonary stenosis" EXACT []
synonym: "subpulmonic stenosis" EXACT []
xref: Fyler:1639
is_a: MP:0010428 ! abnormal heart right ventricle outflow tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-28T04:21:35Z

[Term]
id: MP:0010450
name: atrial septal aneurysm
def: "a saclike thinning, stretching and widening of the heart atrial septum resulting from weakening of the septum wall" [ISBN:0-683-40008-8]
synonym: "interatrial septum aneurysm" EXACT []
is_a: MP:0000282 ! abnormal interatrial septum morphology
is_a: MP:0003279 ! aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T09:36:46Z

[Term]
id: MP:0010451
name: kidney microaneurysm
def: "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8]
synonym: "renal microaneurysms" RELATED []
is_a: MP:0000530 ! abnormal kidney vasculature morphology
is_a: MP:0003279 ! aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T09:39:41Z

[Term]
id: MP:0010452
name: retina microaneurysm
def: "focal dilation of arteriocapillary junctions in the retina" [ISBN:0-683-40008-8]
synonym: "retinal microaneurysm" EXACT []
is_a: MP:0002792 ! abnormal retina vasculature morphology
is_a: MP:0003279 ! aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T09:41:51Z

[Term]
id: MP:0010453
name: abnormal coronary vein morphology
def: "any structural anomaly of any of the veins that return blood from the heart muscles to the right atrium through the coronary sinus" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002725 ! abnormal vein morphology
is_a: MP:0010551 ! abnormal coronary vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T11:15:29Z

[Term]
id: MP:0010454
name: abnormal truncus arteriosus septation
alt_id: MP:0005674
def: "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal aortico-pulmonary septum formation" EXACT []
synonym: "abnormal common arterial trunk septation" EXACT []
is_a: MP:0006126 ! abnormal cardiac outflow tract development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T12:23:33Z

[Term]
id: MP:0010455
name: aortopulmonary window
def: "a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "aortico-pulmonary window" EXACT []
synonym: "aortopulmonary fistula" EXACT []
synonym: "AP window" RELATED []
synonym: "APW" RELATED []
xref: Fyler:0560
xref: Fyler:560
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0010454 ! abnormal truncus arteriosus septation
is_a: MP:0010651 ! aorticopulmonary septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T01:11:11Z

[Term]
id: MP:0010456
name: hemitruncus
def: "congenital heart defect in which the origin of a pulmonary artery, usually the right, arises from the ascending aorta instead of the pulmonary trunk with the aortic and pulmonary valves remaining separate" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:0550
xref: Fyler:550
is_a: MP:0000484 ! abnormal pulmonary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T01:25:09Z

[Term]
id: MP:0010457
name: pulmonary artery stenosis
def: "abnormal narrowing or constriction of the pulmonary artery" [https://orcid.org/0000-0003-3691-0324]
comment: Do not confuse with pulmonary valve stenosis.
subset: CvDC_Terms
synonym: "pulmonary arterial stenosis" EXACT []
synonym: "pulmonary stenosis" RELATED []
xref: Fyler:1622
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0006135 ! artery stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:28:28Z

[Term]
id: MP:0010458
name: pulmonary trunk hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pulmonary trunk, typically resulting in decreased size" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "hypoplastic pulmonary trunk" EXACT []
is_a: MP:0000486 ! abnormal pulmonary trunk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:36:52Z

[Term]
id: MP:0010459
name: supravalvar pulmonary trunk stenosis
def: "diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve" [ISBN:0-683-40008-8]
subset: CvDC_Terms
is_a: MP:0000486 ! abnormal pulmonary trunk morphology
is_a: MP:0006135 ! artery stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:41:37Z

[Term]
id: MP:0010460
name: pulmonary artery hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pulmonary artery, typically resulting in decreased size" [MESH:A07.231.114.715]
subset: CvDC_Terms
synonym: "hypoplastic main pulmonary artery" EXACT []
synonym: "pulmonary arterial hypoplasia" EXACT []
xref: Fyler:2966
is_a: MP:0000484 ! abnormal pulmonary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:46:23Z

[Term]
id: MP:0010461
name: discontinuous pulmonary artery
def: "one or more pulmonary arteries is disconnected from the main pulmonary trunk and arises from a patent ductus arteriosus" [PMID:15902835]
subset: CvDC_Terms
synonym: "discontinuous pulmonary arteries" EXACT []
synonym: "non-confluent pulmonary arteries" EXACT []
synonym: "pulmonary artery discontinuity" EXACT []
is_a: MP:0000484 ! abnormal pulmonary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:51:21Z

[Term]
id: MP:0010462
name: pulmonary artery aneurysm
def: "a protruding sac formed by the dilation of the wall of a pulmonary artery resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "pulmonary arterial aneurysm" EXACT []
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0003279 ! aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T02:55:24Z

[Term]
id: MP:0010463
name: aorta stenosis
def: "diffuse constriction or narrowing of the aorta" [https://orcid.org/0000-0003-3691-0324]
comment: Do not confuse with aortic valve stenosis.
subset: CvDC_Terms
synonym: "aortic stenosis" RELATED []
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0006135 ! artery stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T03:08:21Z

[Term]
id: MP:0010464
name: abnormal aortic arch and aortic arch branch attachment
def: "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "aortic arch branch abnormality" EXACT []
xref: Fyler:2705
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T03:29:54Z

[Term]
id: MP:0010465
name: aberrant origin of the right subclavian artery
def: "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "aberrant origin right subclavian artery" RELATED []
synonym: "abnormal right subclavian artery origin" EXACT []
is_a: MP:0010464 ! abnormal aortic arch and aortic arch branch attachment
is_a: MP:0010487 ! abnormal right subclavian artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T03:33:08Z

[Term]
id: MP:0010466
name: vascular ring
def: "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "aortic vascular ring" EXACT []
xref: Fyler:2760
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T03:44:33Z

[Term]
id: MP:0010467
name: pulmonary artery sling
def: "anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery, with the anomalous left pulmonary artery coursing over the right mainstem bronchus and then from right to left, posterior to the trachea or carina and anterior to the esophagus, to reach the hilum of the left lung, which compresses the lower trachea and right mainstem bronchus" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "pulmonary arterial sling" EXACT []
is_a: MP:0010466 ! vascular ring
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-29T04:22:55Z

[Term]
id: MP:0010468
name: abnormal thoracic aorta morphology
def: "any structural anomaly of the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com]
xref: MA:0002569
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:03:29Z

[Term]
id: MP:0010469
name: ascending aorta hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ascending aorta, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplasia ascending aorta" EXACT []
synonym: "hypoplastic ascending aorta" EXACT []
xref: Fyler:2703
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:27:38Z

[Term]
id: MP:0010470
name: dilated ascending aorta
def: "the luminal space of the ascending aorta is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "ascending aorta dilation" EXACT []
synonym: "dilated ascending aortae" EXACT []
synonym: "dilated ascending aortas" EXACT []
xref: Fyler:2701
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:28:04Z

[Term]
id: MP:0010471
name: supravalvar aortic stenosis
def: "a narrowing, diffuse constriction or obstruction of the ascending aorta located just distal to the aortic valve at the aortic root" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "Aortic stenosis - supravalvar" EXACT []
synonym: "ascending aorta stenosis" EXACT []
synonym: "supravalvar stenosis" EXACT []
synonym: "supravalvular aortic stenosis" EXACT []
xref: Fyler:1430
is_a: MP:0010463 ! aorta stenosis
is_a: MP:0011572 ! abnormal aorta bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:28:48Z

[Term]
id: MP:0010472
name: abnormal ascending aorta and coronary artery attachment
def: "any anomaly of the connection site of any or all of the coronary arteries to the ascending aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
is_a: MP:0004111 ! abnormal coronary artery morphology
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:34:42Z

[Term]
id: MP:0010473
name: descending aorta dilation
def: "widening or enlargment of the lumen of the descending aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:2754
is_a: MP:0009869 ! abnormal descending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:40:28Z

[Term]
id: MP:0010474
name: descending aorta hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the descending aorta, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic descending aorta" EXACT []
xref: Fyler:2753
is_a: MP:0009869 ! abnormal descending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:41:41Z

[Term]
id: MP:0010475
name: anomalous pulmonary origin of left coronary artery
def: "the left coronary artery arises from the pulmonary artery insead of the aorta" [https://orcid.org/0000-0003-3691-0324, PMID:12238882]
comment: "anomalous" was used in the term name instead of "abnormal" due to common usage of this term among cardiologists.
subset: CvDC_Terms
synonym: "ALCAPA" EXACT []
synonym: "ALCPA" NARROW []
xref: Fyler:3101
is_a: MP:0010472 ! abnormal ascending aorta and coronary artery attachment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:45:02Z

[Term]
id: MP:0010476
name: coronary fistula
def: "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "coronary artery fistula" EXACT []
xref: Fyler:2230
is_a: MP:0004111 ! abnormal coronary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:52:34Z

[Term]
id: MP:0010477
name: coronary artery aneurysm
def: "a protruding sac formed by the dilation of the wall of a coronary artery resulting from a weakening of the vessel wall" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "coronary arterial aneurysm" EXACT []
xref: Fyler:3129
is_a: MP:0003279 ! aneurysm
is_a: MP:0004111 ! abnormal coronary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T09:57:14Z

[Term]
id: MP:0010478
name: intracranial aneurysm
def: "a protruding sac within the cranial space formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003279 ! aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T10:04:22Z

[Term]
id: MP:0010479
name: brain aneurysm
def: "a protruding sac within the brain formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003279 ! aneurysm
is_a: MP:0004950 ! abnormal brain vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T10:04:31Z

[Term]
id: MP:0010480
name: pulmonary arteriovenous malformation
def: "abnormal communications between the pulmonary arteries and the pulmonary veins, or between a bronchial artery and the pulmonary vein" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "PAVM" EXACT []
synonym: "pulmonary arteriovenous fistula" EXACT []
xref: Fyler:2210
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0002726 ! abnormal pulmonary vein morphology
is_a: MP:0006093 ! arteriovenous malformation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T10:40:06Z

[Term]
id: MP:0010481
name: heart left ventricle to aorta tunnel
def: "an abnormal communication between the left ventricle and the ascending aorta in addition to the aortic valve" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "aortic-left ventricular tunnel" EXACT []
synonym: "aorto-LV tunnel" EXACT []
synonym: "left ventricle to aorta tunnel" EXACT []
synonym: "left ventricular aortic tunnel" EXACT []
synonym: "LV to aorta tunnel" EXACT []
xref: Fyler:1460
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T10:46:56Z

[Term]
id: MP:0010482
name: abnormal aortic sinus morphology
def: "any structural anomaly of the spaces betwen the superior aspect of each of the three cusps of the aortic valve and the dilated portion of the wall of the ascending aorta, immediately above each cusp; the three sinuses include the posterior (non-coronary sinus), and the right and left aortic sinuses (from which the left and right coronary arteries arise)" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal Petit sinus morphology" EXACT []
synonym: "abnormal sinus of Valsalva morphology" EXACT []
synonym: "abnormal Valsalva sinus morphology" EXACT []
is_a: MP:0011572 ! abnormal aorta bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T10:52:58Z

[Term]
id: MP:0010483
name: aortic sinus aneurysm
def: "a protruding sac formed by the dilation of the wall of the aortic sinus resulting from a weakening of the vessel wall" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "aortic sinus of Valsalva aneurysm" EXACT []
synonym: "Petit sinus aneurysm" EXACT []
synonym: "sinus of Valsalva aneurysm" EXACT []
synonym: "Valsalva sinus aneurysm" EXACT []
xref: Fyler:2316
is_a: MP:0010482 ! abnormal aortic sinus morphology
is_a: MP:0010661 ! ascending aorta aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:07:45Z

[Term]
id: MP:0010484
name: bicuspid aortic valve
def: "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "BAV" EXACT []
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:19:01Z

[Term]
id: MP:0010485
name: aortic arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the aortic arch, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic aortic arch" EXACT []
xref: Fyler:2704
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:22:31Z

[Term]
id: MP:0010486
name: absent right subclavian artery
def: "absence of one of the two subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
is_a: MP:0010487 ! abnormal right subclavian artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:55:35Z

[Term]
id: MP:0010487
name: abnormal right subclavian artery morphology
def: "any structural anomaly of the artery that normally extends from the brachiocephalic artery to the right side of the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal RSA morphology" EXACT []
is_a: MP:0003395 ! abnormal subclavian artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:56:57Z

[Term]
id: MP:0010488
name: abnormal left subclavian artery morphology
def: "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal LSCA morphology" EXACT []
is_a: MP:0003395 ! abnormal subclavian artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T11:57:31Z

[Term]
id: MP:0010489
name: abnormal heart atrium auricular region morphology
def: "any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal atrial appendage morphology" EXACT []
synonym: "abnormal atrial auricles" EXACT []
synonym: "abnormal auricle of atria morphology" EXACT []
synonym: "abnormal auricular appendix" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:20:12Z

[Term]
id: MP:0010490
name: abnormal inferior vena cava valve morphology
def: "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal Eustachian valve morphology" EXACT []
synonym: "abnormal sylvian valve morphology" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology
is_a: MP:0003922 ! abnormal heart right atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:54:02Z

[Term]
id: MP:0010491
name: abnormal coronary sinus valve morphology
def: "any structural anomaly of the semicircular fold of the right atrial endocardium located at the coronary sinus attachment to the right atrium that serves to prevent the reflux of blood back to the coronary arteries during atrial contraction" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal coronary valve morphology" EXACT []
synonym: "abnormal Thebesian valve morphology" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology
is_a: MP:0003922 ! abnormal heart right atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:54:34Z

[Term]
id: MP:0010492
name: abnormal atrium endocardium morphology
def: "any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the atria" [MESH:A07.541.207]
subset: CvDC_Terms
synonym: "abnormal atrial endocardium" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0003974 ! abnormal endocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:33:34Z

[Term]
id: MP:0010493
name: abnormal atrium myocardium morphology
def: "any structural anomaly of the atrial part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8]
synonym: "abnormal atrial myocardium morphology" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:34:03Z

[Term]
id: MP:0010494
name: abnormal ventricle endocardium morphology
def: "any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the ventricles" [MESH:A07.541.207]
synonym: "abnormal ventricular endocardium morphology" EXACT []
is_a: MP:0003974 ! abnormal endocardium morphology
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T12:39:53Z

[Term]
id: MP:0010495
name: abnormal crista terminalis morphology
def: "any structural anomaly of the vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium" [ISBN:0-683-40008-8]
subset: CvDC_Terms
is_a: MP:0003922 ! abnormal heart right atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T01:15:45Z

[Term]
id: MP:0010496
name: abnormal pectinate muscle morphology
def: "any structural anomaly of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal pectinate fibers" EXACT []
is_a: MP:0010493 ! abnormal atrium myocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T01:16:19Z

[Term]
id: MP:0010497
name: abnormal vena cava sinus morphology
def: "any structural anomaly of the portion of the cavity of the right atrium of the heart that receives the blood from the vena cavae and is separated from the rest of the atrium by the crista terminalis" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "abnormal sinus of the vena cava" EXACT []
is_a: MP:0003922 ! abnormal heart right atrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T01:19:16Z

[Term]
id: MP:0010498
name: abnormal interventricular septum muscular part morphology
def: "any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal muscular interventricular septum morphology" EXACT []
is_a: MP:0000281 ! abnormal interventricular septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T01:36:30Z

[Term]
id: MP:0010499
name: abnormal ventricle myocardium morphology
def: "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8]
synonym: "abormal ventricular myocardium morphology" EXACT []
is_a: MP:0005294 ! abnormal heart ventricle morphology
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T01:40:18Z

[Term]
id: MP:0010500
name: myocardium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart myocardium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic myocardium" EXACT []
synonym: "myocardial hypoplasia" EXACT []
is_a: MP:0002740 ! heart hypoplasia
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T03:49:07Z

[Term]
id: MP:0010501
name: atrium myocardium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the atrial myocardium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "atrial myocardium hypoplasia" EXACT []
synonym: "hypoplastic atrial myocardium" EXACT []
is_a: MP:0004055 ! heart atrium hypoplasia
is_a: MP:0010493 ! abnormal atrium myocardium morphology
is_a: MP:0010500 ! myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T03:49:21Z

[Term]
id: MP:0010502
name: ventricle myocardium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ventricle myocardium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "ventricular myocardium hypoplasia" EXACT []
is_a: MP:0000279 ! ventricular hypoplasia
is_a: MP:0010499 ! abnormal ventricle myocardium morphology
is_a: MP:0010500 ! myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T03:49:55Z

[Term]
id: MP:0010503
name: myocardial trabeculae hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the myocardial trabeculae, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic myocardial trabeculae" EXACT []
synonym: "myocardium trabeculae hypoplasia" EXACT []
is_a: MP:0002189 ! abnormal myocardial trabeculae morphology
is_a: MP:0010500 ! myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:04:08Z

[Term]
id: MP:0010504
name: abnormal RR interval
def: "anomaly in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:10:08Z

[Term]
id: MP:0010505
name: abnormal T wave
def: "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:12:12Z

[Term]
id: MP:0010506
name: prolonged RR interval
def: "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased RR interval" EXACT []
synonym: "widened RR interval" EXACT []
is_a: MP:0005333 ! decreased heart rate
is_a: MP:0010504 ! abnormal RR interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:14:41Z

[Term]
id: MP:0010507
name: shortened RR interval
def: "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased RR interval" EXACT []
synonym: "reduced RR interval" EXACT []
is_a: MP:0002626 ! increased heart rate
is_a: MP:0010504 ! abnormal RR interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:15:01Z

[Term]
id: MP:0010508
name: abnormal heart electrocardiography waveform feature
def: "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [https://orcid.org/0000-0003-3691-0324, PMID:20410536]
synonym: "abnormal cardiac electrocardiography" EXACT []
synonym: "abnormal ECG" EXACT []
synonym: "abnormal EKG" EXACT []
synonym: "abnormal heart ECG waveform features" RELATED []
is_a: MP:0003137 ! abnormal impulse conducting system conduction
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-09-30T04:16:30Z

[Term]
id: MP:0010509
name: decreased P wave amplitude
def: "reduction in the size (height or maximum displacement) of the P wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced P wave amplitude" EXACT []
is_a: MP:0004070 ! abnormal P wave
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T09:28:25Z

[Term]
id: MP:0010510
name: absent P wave
def: "absence of the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004070 ! abnormal P wave
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T09:32:59Z

[Term]
id: MP:0010511
name: shortened PR interval
def: "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased PR interval" EXACT []
synonym: "reduced PR interval" EXACT []
is_a: MP:0003901 ! abnormal PR interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T09:40:04Z

[Term]
id: MP:0010512
name: absent PR interval
def: "absence of the ECG segment representing the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003901 ! abnormal PR interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T09:44:16Z

[Term]
id: MP:0010513
name: abnormal ventricular activation time
def: "any anomaly in the length of time from the beginning of the Q wave to the peak of the R wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal VAT" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T10:02:20Z

[Term]
id: MP:0010514
name: fragmented QRS complex
def: "changes in QRS waveform pattern including different RSR' patterns, additional R waves, notched or absent Q or S wave, or more than one R wave" [PMID:20186984]
synonym: "fQRS" EXACT []
synonym: "QRS complex fragmentation" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T10:08:55Z

[Term]
id: MP:0010515
name: abnormal Q wave
def: "any anomaly in the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum" [PMID:16939833]
synonym: "abnormal septal Q wave" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T10:18:32Z

[Term]
id: MP:0010516
name: absent Q wave
def: "absence of the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum" [https://orcid.org/0000-0003-3691-0324, PMID:16939833]
is_a: MP:0010515 ! abnormal Q wave
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T10:20:55Z

[Term]
id: MP:0010517
name: abnormal Bachmann's bundle morphology
def: "any structural anomaly of the impulse conduction tract that originates in the sinoatrial node and transmits signal to the left atrium" [https://orcid.org/0000-0003-3691-0324]
comment: According to Stedman's Medical Dictionary, the anatomic reality of this structure has been disputed.
synonym: "abnormal anterior interatrial band morphology" EXACT []
synonym: "abnormal anterior internodal tract morphology" EXACT []
is_a: MP:0004123 ! abnormal impulse conducting system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T10:36:16Z

[Term]
id: MP:0010519
name: atrioventricular block
def: "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8]
synonym: "AV block" EXACT []
is_a: MP:0006141 ! abnormal atrioventricular node conduction
is_a: MP:0010559 ! heart block
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:06:10Z

[Term]
id: MP:0010520
name: sinoatrial block
def: "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "S-A block" EXACT []
synonym: "SA block" EXACT []
synonym: "sinauricular block" EXACT []
synonym: "sinuatrial block" EXACT []
synonym: "sinus block" RELATED []
xref: Fyler:7014
is_a: MP:0006142 ! abnormal sinoatrial node conduction
is_a: MP:0010559 ! heart block
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:07:27Z

[Term]
id: MP:0010521
name: absent pulmonary artery
def: "absence of the artery that arises from the right ventricle and conveys unaerated blood to the lungs" [MESH:A07.231.114.715]
synonym: "pulmonary artery atresia" BROAD []
is_a: MP:0000484 ! abnormal pulmonary artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2010-10-01T12:21:39Z

[Term]
id: MP:0010522
name: calcified aorta
def: "pathologic deposition of calcium salts in the aorta" [https://orcid.org/0000-0003-3691-0324]
synonym: "aorta calcification" BROAD []
synonym: "aortic calcification" EXACT []
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0006133 ! calcified artery
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:23:16Z

[Term]
id: MP:0010523
name: calcified thoracic aorta
def: "pathologic deposition of calcium salts in the part of the aorta that extends from the origin at the heart to the diaphragm" [https://orcid.org/0000-0003-3691-0324]
synonym: "thoracic aorta calcification" BROAD []
is_a: MP:0010468 ! abnormal thoracic aorta morphology
is_a: MP:0010522 ! calcified aorta
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:27:30Z

[Term]
id: MP:0010524
name: calcified aortic arch
def: "pathologic deposition of calcium salts in the convex portion of the aorta between the ascending and descending parts of the aorta" [https://orcid.org/0000-0003-3691-0324]
synonym: "aortic arch calcification" BROAD []
is_a: MP:0004113 ! abnormal aortic arch morphology
is_a: MP:0010523 ! calcified thoracic aorta
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:29:32Z

[Term]
id: MP:0010525
name: abdominal aorta coarctation
def: "a congenital focal constriction of the abdominal aorta" [https://orcid.org/0000-0003-3691-0324]
synonym: "coarctation of abdominal aorta" EXACT []
is_a: MP:0003387 ! aorta coarctation
is_a: MP:0009870 ! abnormal abdominal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:35:46Z

[Term]
id: MP:0010526
name: aortic arch coarctation
def: "a congenital focal constriction of the aortic arch" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003387 ! aorta coarctation
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:40:37Z

[Term]
id: MP:0010527
name: bicuspid pulmonary valve
def: "the presence of two cusps or leaflets in the pulmonary valve instead of three" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "bicuspid pulmonic valve" EXACT []
xref: Fyler:1601
is_a: MP:0010602 ! abnormal pulmonary valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T12:53:18Z

[Term]
id: MP:0010528
name: pulmonary vein hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pulmonary vein, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic pulmonary vein" EXACT []
is_a: MP:0002726 ! abnormal pulmonary vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:07:18Z

[Term]
id: MP:0010529
name: hepatic arteriovenous malformation
def: "congenital vascular anomaly in the liver characterized by direct communication between an artery and a vein without passing through the capillary bed" [https://orcid.org/0000-0003-3691-0324]
synonym: "hepatic arteriovenous fistula" EXACT []
synonym: "liver arteriovenous fisutla" RELATED []
synonym: "liver arteriovenous malformation" EXACT []
is_a: MP:0006093 ! arteriovenous malformation
is_a: MP:0009820 ! abnormal liver vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:28:56Z

[Term]
id: MP:0010530
name: cerebral arteriovenous malformation
def: "congenital vascular anomaly in the cerebrum characterized by direct communication between an artery and a vein without passing through the capillary bed" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "cerebral arteriovenous fistula" EXACT []
xref: Fyler:2201
is_a: MP:0004950 ! abnormal brain vasculature morphology
is_a: MP:0006093 ! arteriovenous malformation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:29:30Z

[Term]
id: MP:0010531
name: gastrointestinal arteriovenous malformation
def: "congenital vascular anomaly in the gastrointestinal system characterized by direct communication between an artery and a vein without passing through the capillary bed" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0006093 ! arteriovenous malformation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:30:40Z

[Term]
id: MP:0010532
name: absent atrioventricular node
def: "absence of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus" [MESH:A07.541.409.147]
synonym: "absent A-V node" EXACT []
synonym: "absent atrio-ventricular node" EXACT []
synonym: "absent AV node" EXACT []
is_a: MP:0004114 ! abnormal atrioventricular node morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:39:18Z

[Term]
id: MP:0010533
name: atrioventricular node hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the atrioventricular node, typically resulting in decreased size" [MESH:A07.541.409.147]
synonym: "hypoplastic atrioventricular node" EXACT []
is_a: MP:0031531 ! decreased atrioventricular node size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:39:42Z

[Term]
id: MP:0010534
name: calcified myocardium
def: "pathologic deposition of calcium salts in the myocardium" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "myocardial calcification" RELATED []
xref: Fyler:1889
is_a: MP:0002837 ! dystrophic cardiac calcinosis
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:42:43Z

[Term]
id: MP:0010535
name: myocardium steatosis
def: "an accumulation of fat deposits in the myocardium" [https://orcid.org/0000-0003-3691-0324]
synonym: "myocardial steatosis" EXACT []
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:44:57Z

[Term]
id: MP:0010536
name: Ebstein's malformation of tricuspid valve
def: "a congenital downward displacement of the septal and posterior leaflets of the tricuspid valve into the inlet portion of the right ventricle" [http://emedicine.medscape.com, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "Ebstein disease" EXACT []
synonym: "Ebstein's anomaly" EXACT []
synonym: "Ebstein's anomaly of the right atrioventricular valve" EXACT []
synonym: "Ebstein's anomaly of the right AV valve" EXACT []
synonym: "Ebstein's anomaly of the tricuspid valve" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T02:51:23Z

[Term]
id: MP:0010537
name: tumor regression
def: "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [https://orcid.org/0000-0003-0431-8641]
synonym: "tumour regression" EXACT []
is_a: MP:0010639 ! abnormal tumor pathology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T03:25:26Z

[Term]
id: MP:0010538
name: increased level of surface class II molecules
def: "increase in the concentration of major histocompatibility complex class II molecules expressed at the cell surface" [https://orcid.org/0000-0001-5013-1234]
is_a: MP:0005042 ! abnormal level of surface class II molecules
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T03:29:41Z

[Term]
id: MP:0010539
name: decreased level of surface class II molecules
def: "reduction in the concentration of major histocompatibility complex class II molecules expressed at the cell surface" [https://orcid.org/0000-0001-5013-1234]
synonym: "reduced level of surface class II molecules" EXACT []
is_a: MP:0005042 ! abnormal level of surface class II molecules
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T03:30:09Z

[Term]
id: MP:0010540
name: long stride length
def: "increased average distance between steps" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased stride length" EXACT []
synonym: "large stride length" EXACT []
is_a: MP:0012690 ! abnormal stride length
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-01T03:44:04Z

[Term]
id: MP:0010541
name: aorta hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the aorta, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "aortic hypoplasia" EXACT []
synonym: "hypoplastic aorta" EXACT []
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:09:24Z

[Term]
id: MP:0010542
name: right ventricular myocardium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the right ventricular myocardium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic right ventricular myocardium" EXACT []
synonym: "parchment heart" EXACT []
synonym: "right ventricular hypoplasia" BROAD []
is_a: MP:0003649 ! decreased heart right ventricle size
is_a: MP:0010502 ! ventricle myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:14:52Z

[Term]
id: MP:0010543
name: aorta tubular hypoplasia
def: "a diffuse narrowing of the lumen of the aorta" [https://orcid.org/0000-0003-3691-0324]
comment: Hypoplasia in the term name is not necessarily consistent with usage in the rest of the ontology (underdevelopment vs narrowing of the lumen), but this is the term name used by cardiologists.
subset: CvDC_Terms
synonym: "aortic tubular hypoplasia" EXACT []
synonym: "narrow aorta lumen" EXACT []
synonym: "narrow aortic lumen" EXACT []
is_a: MP:0010541 ! aorta hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:28:50Z

[Term]
id: MP:0010544
name: interrupted aorta
def: "complete discontinuation or blockage in the aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:35:33Z

[Term]
id: MP:0010545
name: abnormal heart layer morphology
def: "any structural anomaly of the laminar structure of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiac layer morphology" EXACT []
synonym: "abnormal heart wall morphology" RELATED []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:53:37Z

[Term]
id: MP:0010546
name: abnormal subendocardium layer morphology
def: "any structural anomaly of the layer of loose fibrous tissue located between the endocardium and myocardium which contains the nerves and the impulse-conducting system (Purkinje fibers) of the heart" [ISBN:0-683-40008-8]
synonym: "abnormal subendocardial layer morphology" EXACT []
is_a: MP:0010545 ! abnormal heart layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T09:54:44Z

[Term]
id: MP:0010547
name: abnormal mesocardium morphology
def: "any structural anomaly of the layer of splanchnic mesoderm supporting the embryonic heart in the pericardial cavity; mesocardium normally regresses before birth" [ISBN:0-683-40008-8]
is_a: MP:0000267 ! abnormal heart development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T10:07:54Z

[Term]
id: MP:0010548
name: abnormal dorsal mesocardium morphology
def: "any structural anomaly of the part of the mesocardium that lies dorsal to the embryonic heart; the dorsal mesocardium gives rise to the transverse sinus of the pericardium in the adult" [ISBN:0-683-40008-8]
is_a: MP:0010547 ! abnormal mesocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T10:08:09Z

[Term]
id: MP:0010549
name: absent dorsal mesocardium
def: "absence of the part of the mesocardium that lies dorsal to the embryonic heart; the dorsal mesocardium gives rise to the transverse sinus of the pericardium in the adult" [ISBN:0-683-40008-8]
is_a: MP:0010548 ! abnormal dorsal mesocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T10:08:24Z

[Term]
id: MP:0010551
name: abnormal coronary vessel morphology
def: "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal coronary vasculature" EXACT []
synonym: "abnormal heart blood vessel morphology" RELATED []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:15:24Z

[Term]
id: MP:0010552
name: abnormal HV interval
def: "any anomaly in the time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8]
synonym: "abnormal H-V interval" EXACT []
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:22:27Z

[Term]
id: MP:0010553
name: prolonged HV interval
def: "increase in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8]
synonym: "prolonged H-V interval" EXACT []
is_a: MP:0010552 ! abnormal HV interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:24:29Z

[Term]
id: MP:0010554
name: shortened HV interval
def: "decrease in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8]
synonym: "decreased HV interval" EXACT []
synonym: "reduced HV interval" EXACT []
synonym: "shortened H-V interval" EXACT []
is_a: MP:0010552 ! abnormal HV interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:24:49Z

[Term]
id: MP:0010555
name: absent epicardium
def: "absence of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [ISBN:0-683-40008-8]
synonym: "absent lamina visceralis pericardii" EXACT []
synonym: "absent visceral layer of serous pericardium" EXACT []
synonym: "absent visceral serous pericardium" EXACT []
is_a: MP:0003057 ! abnormal epicardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:35:36Z

[Term]
id: MP:0010556
name: thin ventricle myocardium compact layer
def: "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [https://orcid.org/0000-0003-3691-0324]
synonym: "thin ventricle myocardium compact zone" EXACT []
synonym: "thin ventricular myocardial compact layer" EXACT []
synonym: "thin ventricular myocardial compact zone" EXACT []
is_a: MP:0004057 ! thin myocardium compact layer
is_a: MP:0010502 ! ventricle myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:39:09Z

[Term]
id: MP:0010557
name: dilated pulmonary artery
def: "the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated pulmonary arteries" EXACT []
synonym: "pulmonary artery dilation" EXACT []
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0004938 ! dilated vasculature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:50:53Z

[Term]
id: MP:0010558
name: sinus venosus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the sinus venosus, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic sinus venosus" EXACT []
is_a: MP:0003228 ! abnormal sinus venosus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T01:54:25Z

[Term]
id: MP:0010559
name: heart block
def: "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiac block" EXACT []
synonym: "cardiac conduction block" EXACT []
is_a: MP:0003137 ! abnormal impulse conducting system conduction
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T02:01:21Z

[Term]
id: MP:0010560
name: intraventricular block
def: "absent or delayed conduction within the ventricular conducting system or in the ventricular myocardium" [ISBN:0-683-40008-8]
synonym: "IVB" EXACT []
is_a: MP:0010559 ! heart block
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T02:03:24Z

[Term]
id: MP:0010561
name: absent coronary vessels
def: "absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010551 ! abnormal coronary vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T02:15:21Z

[Term]
id: MP:0010562
name: absent sinus venosus
def: "absence of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003228 ! abnormal sinus venosus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T02:32:55Z

[Term]
id: MP:0010563
name: increased heart right ventricle size
alt_id: MP:0008773
def: "greater than average size of the right ventricle" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged heart right ventricle" EXACT []
is_a: MP:0008772 ! increased heart ventricle size
is_a: MP:0010577 ! abnormal heart right ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T02:44:37Z

[Term]
id: MP:0010564
name: abnormal fetal ductus arteriosus morphology
def: "any structural anomaly of the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth" [ISBN:0-683-40008-8]
synonym: "abnormal arterial canal morphology" EXACT []
synonym: "abnormal arterial duct morphology" EXACT []
synonym: "abnormal Botallo duct morphology" EXACT []
synonym: "abnormal ductus Botallo morphology" EXACT []
synonym: "abnormal foetal ductus arteriosus morphology" EXACT []
is_a: MP:0000259 ! abnormal vascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T03:38:44Z

[Term]
id: MP:0010565
name: absent fetal ductus arteriosus
def: "absence of the fetal vessel that connects the left pulmonary artery with the descending aorta" [ISBN:0-683-40008-8]
synonym: "absent arterial canal" EXACT []
synonym: "absent arterial duct" EXACT []
synonym: "absent Botallo duct" EXACT []
synonym: "absent ductus Botallo" EXACT []
synonym: "absent foetal ductus arteriosus" EXACT []
is_a: MP:0010564 ! abnormal fetal ductus arteriosus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T03:39:09Z

[Term]
id: MP:0010566
name: abnormal left posterior bundle morphology
def: "any structural anomaly of the left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber" [ISBN:0-683-40008-8]
synonym: "abnormal left bundle of atrioventricular bundle" EXACT []
synonym: "abnormal left crus of atrioventricular bundle" EXACT []
synonym: "abnormal left ventricular bundle branch morphology" EXACT []
is_a: MP:0004117 ! abnormal atrioventricular bundle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T04:02:04Z

[Term]
id: MP:0010567
name: abnormal right bundle morphology
def: "any structural anomaly of the right branch of the atrioventricular bundle that separates just below the bundle of His, descends the septal wall of the right ventricle and connects to the terminal Purkinje fibers" [ISBN:0-683-40008-8]
synonym: "abnormal right bundle of atrioventricular bundle" EXACT []
synonym: "abnormal right crus of atrioventricular bundle" EXACT []
synonym: "abnormal right ventricular bundle morphology" EXACT []
is_a: MP:0004117 ! abnormal atrioventricular bundle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T04:02:30Z

[Term]
id: MP:0010568
name: abnormal bulbus cordis morphology
def: "any structural anomaly of a transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches" [ISBN:0-683-40008-8]
is_a: MP:0000270 ! abnormal heart tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-04T04:15:12Z

[Term]
id: MP:0010569
name: papillary muscle hypertrophy
def: "increased bulk size of any of the ventricular papillary muscles due to cell enlargement" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "hypertrophic papillary muscle" EXACT []
is_a: MP:0031540 ! increased papillary muscle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T09:59:00Z

[Term]
id: MP:0010570
name: prolonged ST segment
def: "increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0003897 ! abnormal ST segment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T10:06:28Z

[Term]
id: MP:0010571
name: shortened ST segment
def: "reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [https://orcid.org/0009-0005-7755-8314]
synonym: "decreased ST segment" EXACT []
synonym: "reduced ST segment" EXACT []
is_a: MP:0003897 ! abnormal ST segment
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T10:07:13Z

[Term]
id: MP:0010572
name: persistent right dorsal aorta
def: "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [https://orcid.org/0000-0003-3691-0324]
synonym: "failure of right dorsal aorta regression" RELATED []
synonym: "right dorsal aorta remnant" EXACT []
is_a: MP:0004787 ! abnormal dorsal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T10:26:31Z

[Term]
id: MP:0010573
name: left dorsal aorta regression
def: "regression of the left dorsal aorta which normally develops into the aortic arch; together with a persistent right dorsal aorta, a right aortic arch forms" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004787 ! abnormal dorsal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T10:31:29Z

[Term]
id: MP:0010574
name: dilated aorta
def: "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "aorta dilation" EXACT []
synonym: "aortic dilation" EXACT []
synonym: "dilated aortae" EXACT []
synonym: "dilated aortas" EXACT []
xref: Fyler:2708
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0004938 ! dilated vasculature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:26:42Z

[Term]
id: MP:0010575
name: aortic arch dilation
def: "the luminal space of the aortic arch is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "aorta arch dilation" EXACT []
xref: Fyler:2706
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:27:29Z

[Term]
id: MP:0010576
name: premature closure of the ductus arteriosus
def: "premature regression of the ductus arteriosus that normally regresses into a fibrous cord, the ligamentum arteriousum after birth" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "premature regression of the ductus arteriosus" EXACT []
is_a: MP:0010564 ! abnormal fetal ductus arteriosus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:44:24Z

[Term]
id: MP:0010577
name: abnormal heart right ventricle size
def: "anomaly of the average size of the right ventricle compared to the average for a particular population" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003920 ! abnormal heart right ventricle morphology
is_a: MP:0031543 ! abnormal heart ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:51:04Z

[Term]
id: MP:0010578
name: abnormal heart left ventricle size
def: "anomaly of the average size of the left ventricle compared to the average for a particular population" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal left ventricle size" EXACT []
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0031543 ! abnormal heart ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:52:23Z

[Term]
id: MP:0010579
name: increased heart left ventricle size
alt_id: MP:0008774
def: "greater than average size of the left ventricle" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged heart left ventricle" EXACT []
synonym: "enlarged left ventricle" EXACT []
is_a: MP:0008772 ! increased heart ventricle size
is_a: MP:0010578 ! abnormal heart left ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:52:42Z

[Term]
id: MP:0010580
name: decreased heart left ventricle size
def: "less than average size of the left ventricle compared to the average for a particular population" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased left ventricle size" EXACT []
synonym: "reduced left ventricle size" EXACT []
is_a: MP:0010578 ! abnormal heart left ventricle size
is_a: MP:0031544 ! decreased heart ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:52:57Z

[Term]
id: MP:0010581
name: abnormal atrium myocardial trabeculae morphology
def: "any structural anomaly of the supporting bundles of muscular fibers lining the walls of the atria" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002189 ! abnormal myocardial trabeculae morphology
is_a: MP:0010493 ! abnormal atrium myocardium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T11:59:35Z

[Term]
id: MP:0010582
name: abnormal bulbus cordis septation
def: "anomaly in the process in which the distal swelling of the primitive heart tube separates into an inferior end, which will form much of the right ventricle, and a superior end, which first form an outflow channel called the conotruncus; the conotruncus will in turn give rise to the more proximal conus cordis and the more distal truncus arteriosus" [ISBN:0-683-40008-8]
is_a: MP:0010568 ! abnormal bulbus cordis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T01:53:41Z

[Term]
id: MP:0010583
name: abnormal conotruncus morphology
def: "any structural anomaly of the distal portion of the bulbus cordis that will give rise to the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [ISBN:0-683-40008-8]
synonym: "abnormal bulbus cordis, rostral half morphology" EXACT []
is_a: MP:0000270 ! abnormal heart tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:09:42Z

[Term]
id: MP:0010584
name: abnormal conotruncus septation
def: "anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal conotruncal septation" EXACT []
is_a: MP:0010583 ! abnormal conotruncus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:16:30Z

[Term]
id: MP:0010585
name: abnormal conotruncal ridge morphology
def: "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [https://orcid.org/0000-0003-3691-0324, PMID:8823298]
synonym: "abnormal aortico-pulmonary spiral ridges" EXACT []
synonym: "abnormal bulbar ridge morphology" EXACT []
synonym: "abnormal conotruncal cushion morphology" EXACT []
synonym: "abnormal conotruncal cushions" EXACT []
synonym: "abnormal conotruncal ridges" EXACT []
synonym: "abnormal endocardial ridges" EXACT []
synonym: "abnormal outflow tract cushion morphology" EXACT []
synonym: "abnormal outflow tract endocardial cushion morphology" EXACT []
is_a: MP:0006126 ! abnormal cardiac outflow tract development
is_a: MP:0010583 ! abnormal conotruncus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:18:13Z

[Term]
id: MP:0010586
name: absent conotruncal ridges
def: "absence of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [https://orcid.org/0000-0003-3691-0324, PMID:8823298]
synonym: "absent aortico-pulmonary spiral ridges" EXACT []
synonym: "absent bulbar ridges" EXACT []
synonym: "absent conotruncal cushion" EXACT []
synonym: "absent conotruncal cushions" EXACT []
synonym: "absent endocardial ridges" EXACT []
synonym: "absent outflow tract cushions" EXACT []
is_a: MP:0010585 ! abnormal conotruncal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:26:19Z

[Term]
id: MP:0010587
name: conotruncal ridge hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the conotruncal ridge, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324, PMID:8823298]
synonym: "aortico-pulmonary spiral ridge hypoplasia" EXACT []
synonym: "bulbar ridge hypoplasia" EXACT []
synonym: "conotruncal cushion hypoplasia" EXACT []
synonym: "hypoplastic conotruncal ridge" EXACT []
synonym: "outflow tract cushion hypoplasia" EXACT []
is_a: MP:0010585 ! abnormal conotruncal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:26:38Z

[Term]
id: MP:0010588
name: conotruncal ridge hyperplasia
def: "increase in the number of normal cells in normal arrangement in the conotruncal ridge, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, PMID:8823298]
synonym: "aortico-pulmonary spiral ridge hyperplasia" EXACT []
synonym: "bulbar ridge hyperplasia" EXACT []
synonym: "conotruncal cushion hyperplasia" EXACT []
synonym: "endocardial ridge hyperplasia" EXACT []
synonym: "hyperplastic conotruncal ridge" EXACT []
synonym: "outflow tract cushion hyperplasia" EXACT []
is_a: MP:0010585 ! abnormal conotruncal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T02:26:55Z

[Term]
id: MP:0010589
name: common truncal valve
def: "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000285 ! abnormal heart valve morphology
is_a: MP:0010454 ! abnormal truncus arteriosus septation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T03:12:22Z

[Term]
id: MP:0010590
name: common truncal valve stenosis
def: "abnormal constriction or narrowing of the single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:1440
is_a: MP:0010589 ! common truncal valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T03:13:47Z

[Term]
id: MP:0010591
name: enlarged aortic valve
def: "an increase in the total area occupied by the aortic valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged aortic semi-lunar valve" EXACT []
synonym: "enlarged aortic semilunar valve" EXACT []
synonym: "enlarged left semi-lunar valve" EXACT []
synonym: "enlarged left semilunar valve" EXACT []
synonym: "enlarged left ventriculoarterial junction" EXACT []
synonym: "increased aortic valve size" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
is_a: MP:0031580 ! enlarged semilunar valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T04:03:55Z

[Term]
id: MP:0010592
name: abnormal atrioventricular septum morphology
def: "any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve" [ISBN:0-683-40008-8]
synonym: "abnormal AV septum morphology" EXACT []
is_a: MP:0006113 ! abnormal heart septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T09:21:20Z

[Term]
id: MP:0010593
name: thick aortic valve cusps
def: "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "thick aortic valve leaflets" EXACT []
synonym: "thickened aortic valve cusps" EXACT []
synonym: "thickened aortic valve leaflets" EXACT []
xref: Fyler:1486
is_a: MP:0010594 ! thick aortic valve
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
is_a: MP:0011648 ! thick heart valve cusps
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T04:04:39Z

[Term]
id: MP:0010594
name: thick aortic valve
def: "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "TAV" EXACT []
synonym: "thick aortic semi-lunar valve" EXACT []
synonym: "thick aortic semilunar valve" EXACT []
synonym: "thick left arterial valve" EXACT []
synonym: "thick left semi-lunar valve" EXACT []
synonym: "thick left semilunar valve" EXACT []
synonym: "thick left ventriculoarterial junction" EXACT []
synonym: "thickened aortic valve" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
is_a: MP:0031584 ! thick semilunar valve
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T04:05:30Z

[Term]
id: MP:0010595
name: abnormal aortic valve cusp morphology
def: "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal aortic valve leaflet morphology" EXACT []
xref: Fyler:1480
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T04:07:55Z

[Term]
id: MP:0010596
name: unicuspid aortic valve
def: "the presence of one cusp and associated flap in the aortic valve instead of three" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-05T04:12:50Z

[Term]
id: MP:0010597
name: absent aortic valve cusps
def: "absence of the three fibrous triangular components and associated flaps of the aortic valve" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "absent aortic cusps" EXACT []
synonym: "absent aortic valve leaflets" EXACT []
xref: Fyler:1484
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T09:44:20Z

[Term]
id: MP:0010598
name: abnormal aortic valve annulus morphology
def: "any structural anomaly of the fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal aortic annulus morphology" EXACT []
synonym: "abnormal aortic anulus morphology" EXACT []
synonym: "abnormal aortic valvar annulus morphology" EXACT []
synonym: "abnormal aortic valvar anulus morphology" EXACT []
synonym: "abnormal aortic valve anulus morphology" EXACT []
synonym: "abnormal fibrous ring of aortic valve" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T09:45:59Z

[Term]
id: MP:0010599
name: abnormal fetal atrioventricular canal septation
def: "anomaly in the process by which the dorsal and ventral endocardial cushions develop in the walls of the common atrioventricular canal, grow toward each other and fuse, dividing the common atrioventricular canal into right and left atrioventricular canals and the atrioventricular septum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal foetal atrioventricular canal septation" EXACT []
synonym: "abnormal partitioning of the atrioventricular canal" EXACT []
is_a: MP:0006107 ! abnormal fetal atrioventricular canal morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T09:58:37Z

[Term]
id: MP:0010600
name: enlarged pulmonary valve
def: "an increase in the total area occupied by the pulmonary valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged pulmonic valve" EXACT []
synonym: "enlarged right arterial valve" EXACT []
synonym: "enlarged right semi-lunar valve" EXACT []
synonym: "enlarged right semilunar valve" EXACT []
synonym: "increased pulmonary valve size" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
is_a: MP:0031580 ! enlarged semilunar valve
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:39:15Z

[Term]
id: MP:0010601
name: thick pulmonary valve
def: "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick pulmonic valve" EXACT []
synonym: "thick right arterial valve" EXACT []
synonym: "thick right semi-lunar valve" EXACT []
synonym: "thick right semilunar valve" EXACT []
synonym: "thickened pulmonary valve" EXACT []
synonym: "TPV" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
is_a: MP:0031584 ! thick semilunar valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:39:35Z

[Term]
id: MP:0010602
name: abnormal pulmonary valve cusp morphology
def: "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "abnormal pulmonary valve leaflet morphology" EXACT []
synonym: "abnormal pulmonic valve cusp morphology" EXACT []
synonym: "abnormal pulmonic valve leaflet morphology" EXACT []
xref: Fyler:1652
is_a: MP:0002748 ! abnormal pulmonary valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:40:42Z

[Term]
id: MP:0010603
name: unicuspid pulmonary valve
def: "the presence of one cusp and associated flap in the pulmonary valve instead of three" [https://orcid.org/0000-0003-3691-0324]
synonym: "unicuspid pulmonic valve" EXACT []
is_a: MP:0010602 ! abnormal pulmonary valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:41:21Z

[Term]
id: MP:0010604
name: absent pulmonary valve cusps
def: "absence of the three fibrous triangular components and associated flaps of the pulmonary valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent pulmonary cusps" EXACT []
synonym: "absent pulmonic valve cusps" EXACT []
is_a: MP:0010602 ! abnormal pulmonary valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:41:41Z

[Term]
id: MP:0010605
name: thick pulmonary valve cusps
def: "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick pulmonary valve leaflets" EXACT []
synonym: "thickened pulmonary valve cusps" EXACT []
synonym: "thickened pulmonary valve leaflets" EXACT []
synonym: "thickened pulmonic valve cusps" EXACT []
is_a: MP:0010601 ! thick pulmonary valve
is_a: MP:0010602 ! abnormal pulmonary valve cusp morphology
is_a: MP:0011648 ! thick heart valve cusps
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:41:59Z

[Term]
id: MP:0010606
name: abnormal pulmonary valve annulus morphology
def: "any structural anomaly of the fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal pulmonary valve anulus morphology" EXACT []
synonym: "abnormal pulmonic valve annulus" EXACT []
synonym: "abnormal pulmonic valve anulus" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T10:42:37Z

[Term]
id: MP:0010607
name: common atrioventricular valve
def: "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "AVSD AV valvar abnormality" BROAD []
synonym: "common AV valve" EXACT []
xref: Fyler:1170
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T12:02:30Z

[Term]
id: MP:0010608
name: abnormal chordae tendineae morphology
def: "any structural anomaly of the tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria" [ISBN:0-683-40008-8]
synonym: "abnormal tendinous cords" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T12:08:58Z

[Term]
id: MP:0010609
name: absent chordae tendineae
def: "absence of the tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria" [ISBN:0-683-40008-8]
synonym: "absent tendinous cords" EXACT []
is_a: MP:0010608 ! abnormal chordae tendineae morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T12:11:51Z

[Term]
id: MP:0010610
name: patent aortic valve
def: "the aortic valve remains open during the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "open aortic valve" EXACT []
synonym: "patent aortic semi-lunar valve" EXACT []
synonym: "patent aortic semilunar valve" EXACT []
synonym: "patent left arterial valve" EXACT []
synonym: "patent left semi-lunar valve" EXACT []
synonym: "patent left semilunar valve" EXACT []
synonym: "patent left ventriculoarterial junction" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T02:33:27Z

[Term]
id: MP:0010611
name: patent pulmonary valve
def: "the pulmonary valve remains open during the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "open pulmonic valve" EXACT []
synonym: "patent pulmonic valve" EXACT []
synonym: "patent right arterial valve" EXACT []
synonym: "patent right semi-lunar valve" EXACT []
synonym: "patent right semilunar valve" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T02:34:57Z

[Term]
id: MP:0010612
name: muscular subaortic stenosis
def: "abnormal narrowing, constriction or obstruction of the left ventricular outflow tract due to hypertrophy of the interventricular septum, which results in obstruction to blood flow" [ISBN:0-683-40008-8]
synonym: "idiopathic hypertrophic subaortic stenosis" EXACT []
is_a: MP:0010448 ! heart left ventricle outflow tract stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:15:43Z

[Term]
id: MP:0010613
name: abnormal mitral valve annulus morphology
def: "any structural anomaly of the fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal bicuspid valve annulus morphology" EXACT []
synonym: "abnormal bicuspid valve anulus morphology" EXACT []
synonym: "abnormal left atrioventricular valve annulus morphology" EXACT []
synonym: "abnormal left atrioventricular valve anulus morphology" EXACT []
synonym: "abnormal left AV valve annulus morphology" EXACT []
synonym: "abnormal left AV valve anulus morphology" EXACT []
synonym: "abnormal mitral valve anulus morphology" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010614
name: abnormal mitral valve cusp morphology
def: "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal bicuspid valve cusp morphology" EXACT []
synonym: "abnormal bicuspid valve leaflet morphology" EXACT []
synonym: "abnormal left atriovntricular valve cusp morphology" EXACT []
synonym: "abnormal left atriovntricular valve leaflet morphology" EXACT []
synonym: "abnormal left AV valve cusp morphology" EXACT []
synonym: "abnormal left AV valve leaflet morphology" EXACT []
synonym: "abnormal mitral valve leaflet morphology" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010615
name: unicuspid mitral valve
def: "the presence of one cusp and associated flap in the mitral valve instead of two" [https://orcid.org/0000-0003-3691-0324]
synonym: "unicuspid bicuspid valve" EXACT []
synonym: "unicuspid left atrioventricular valve" EXACT []
synonym: "unicuspid left AV valve" EXACT []
is_a: MP:0010614 ! abnormal mitral valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010616
name: absent mitral valve cusps
def: "absence of the two fibrous components and associated flaps of the mitral valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent bicuspid valve cusps" EXACT []
synonym: "absent bicuspid valve leaflets" EXACT []
synonym: "absent left atrioventricular valve cusps" EXACT []
synonym: "absent left atrioventricular valve leaflets" EXACT []
synonym: "absent left AV valve cusps" EXACT []
synonym: "absent left AV valve leaflets" EXACT []
synonym: "absent mitral valve leaflets" EXACT []
is_a: MP:0010614 ! abnormal mitral valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010617
name: thick mitral valve cusps
def: "an increase in the ratio of the mitral valve cusp wall thickness to the atrioventricular septum thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick bicuspid valve cusps" EXACT []
synonym: "thick bicuspid valve leaflets" EXACT []
synonym: "thick left atrioventricular valve cusps" EXACT []
synonym: "thick left atrioventricular valve leaflets" EXACT []
synonym: "thick left AV valve cusps" EXACT []
synonym: "thick left AV valve leaflets" EXACT []
synonym: "thickened bicuspid valve cusps" EXACT []
synonym: "thickened bicuspid valve leaflets" EXACT []
synonym: "thickened mitral valve cusps" EXACT []
synonym: "thickened mitral valve leaflets" EXACT []
is_a: MP:0010614 ! abnormal mitral valve cusp morphology
is_a: MP:0010620 ! thick mitral valve
is_a: MP:0011648 ! thick heart valve cusps
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010618
name: enlarged mitral valve
def: "an increase in the total area occupied by the mitral valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged bicuspid valve" EXACT []
synonym: "enlarged left atrioventricular valve" EXACT []
synonym: "enlarged left AV valve" EXACT []
synonym: "increased bicuspid valve size" EXACT []
synonym: "increased left atrioventricular valve size" EXACT []
synonym: "increased left AV valve size" EXACT []
synonym: "increased mitral valve size" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
is_a: MP:0031570 ! enlarged atrioventricular valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010619
name: patent mitral valve
def: "the mitral valve remains open during the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "open bicuspid valve" EXACT []
synonym: "open left atrioventricular valve" EXACT []
synonym: "open left AV valve" EXACT []
synonym: "open mitral valve" EXACT []
synonym: "patent bicuspid valve" EXACT []
synonym: "patent left atrioventricular valve" EXACT []
synonym: "patent left AV valve" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010620
name: thick mitral valve
def: "an increase in the ratio of the mitral valve wall thickness to the atrioventricular septum thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick bicuspid valve" EXACT []
synonym: "thick left atrioventricular valve" EXACT []
synonym: "thick left AV valve" EXACT []
synonym: "thickened bicuspid valve" EXACT []
synonym: "thickened mitral valve" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
is_a: MP:0031574 ! thick atrioventricular valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:48:15Z

[Term]
id: MP:0010621
name: abnormal tricuspid valve annulus morphology
def: "any structural anomaly of the fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal right atrioventricular valve annulus morphology" EXACT []
synonym: "abnormal right AV valve annulus morphology" EXACT []
synonym: "abnormal tricuspid valve anulus morphology" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010622
name: abnormal tricuspid valve cusp morphology
def: "any structural anomaly of the three fibrous triangular components and associated flaps of the tricuspid valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal right atrioventricular valve cusp morphology" EXACT []
synonym: "abnormal right atrioventricular valve leaflet morphology" EXACT []
synonym: "abnormal right AV valve cusp morphology" EXACT []
synonym: "abnormal right AV valve leaflet morphology" EXACT []
synonym: "abnormal tricuspid valve leaflet morphology" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010623
name: bicuspid tricuspid valve
def: "the presence of two cusps and associated flaps in the tricuspid valve instead of three" [https://orcid.org/0000-0003-3691-0324]
synonym: "bicuspid right atrioventricular valve" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "bicuspid right AV valve" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010622 ! abnormal tricuspid valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010624
name: unicuspid tricuspid valve
def: "the presence of one cusp and associated flap in the tricuspid valve instead of three" [https://orcid.org/0000-0003-3691-0324]
synonym: "unicuspid right atrioventricular valve" EXACT [https://orcid.org/0000-0002-6490-7723, UBERON:0002134]
synonym: "unicuspid right AV valve" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010622 ! abnormal tricuspid valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010625
name: absent tricuspid valve cusps
def: "absence of the three fibrous triangular components and associated flaps of the tricuspid valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent right atrioventricular valve cusps" EXACT []
synonym: "absent right atrioventricular valve leaflets" EXACT []
synonym: "absent right AV valve cusps" EXACT []
synonym: "absent right AV valve leaflets" EXACT []
synonym: "absent tricuspid valve leaflets" EXACT []
is_a: MP:0010622 ! abnormal tricuspid valve cusp morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010626
name: thick tricuspid valve cusps
def: "an increase in the ratio of the tricuspid valve cusp wall thickness to the atrioventricular septum thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick right atrioventricular valve cusps" EXACT []
synonym: "thick right atrioventricular valve leaflets" EXACT []
synonym: "thick right AV valve cusps" EXACT []
synonym: "thick right AV valve leaflets" EXACT []
synonym: "thick tricuspid valve leaflets" EXACT []
synonym: "thickened tricuspid valve cusps" EXACT []
synonym: "thickened tricuspid valve leaflets" EXACT []
is_a: MP:0010622 ! abnormal tricuspid valve cusp morphology
is_a: MP:0010629 ! thick tricuspid valve
is_a: MP:0011648 ! thick heart valve cusps
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010627
name: enlarged tricuspid valve
def: "an increase in the total area occupied by the tricuspid valve" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged right atrioventricular valve" EXACT []
synonym: "enlarged right AV valve" EXACT []
synonym: "increased right atrioventricular valve size" EXACT []
synonym: "increased right AV valve size" EXACT []
synonym: "increased tricuspid valve size" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
is_a: MP:0031570 ! enlarged atrioventricular valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010628
name: patent tricuspid valve
def: "the tricuspid valve remains open during the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "open right atrioventricular valve" EXACT []
synonym: "open right AV valve" EXACT []
synonym: "open tricuspid valve" EXACT []
synonym: "patent right atrioventricular valve" EXACT []
synonym: "patent right AV valve" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010629
name: thick tricuspid valve
def: "an increase in the ratio of the tricuspid valve wall thickness to the atrioventricular septum thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick right atrioventricular valve" EXACT []
synonym: "thick right AV valve" EXACT []
synonym: "thickened tricuspid valve" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
is_a: MP:0031574 ! thick atrioventricular valve
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-06T03:50:28Z

[Term]
id: MP:0010630
name: abnormal cardiac muscle tissue morphology
def: "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8]
comment: Do not confuse cardiac muscle tissue with the myocardium. Myocardium consists primarily of cardiac muscle but these structures are not identical. Cardiac muscle tissue also exists outside the heart so this term has not been made a child of heart myocardial layer directly.
synonym: "abnormal cardiac muscle morphology" EXACT []
synonym: "abnormal heart muscle morphology" EXACT []
synonym: "cardiac muscle abnormalities" EXACT []
synonym: "cardiac muscle dysplasia" NARROW []
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0002127 ! abnormal cardiovascular system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2010-10-07T10:28:22Z

[Term]
id: MP:0010631
name: increased Q wave amplitude
def: "increase in the size (height or maximum displacement) of the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum" [https://orcid.org/0000-0003-3691-0324, PMID:16939833]
is_a: MP:0010515 ! abnormal Q wave
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T11:25:47Z

[Term]
id: MP:0010632
name: cardiac muscle necrosis
def: "morphological changes resulting from pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "cardiomyocyte necrosis" EXACT []
synonym: "necrotic cardiac muscle" EXACT []
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T10:40:22Z

[Term]
id: MP:0010633
name: myocardium hypertrophy
def: "an increase in size of the myocardium, not due to increased cell number" [https://orcid.org/0000-0003-3691-0324]
synonym: "myocardial hypertrophy" EXACT []
is_a: MP:0001625 ! cardiac hypertrophy
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T11:57:14Z

[Term]
id: MP:0010634
name: increased QRS amplitude
def: "increased in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased R wave amplitude" EXACT []
is_a: MP:0003898 ! abnormal QRS complex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T01:51:18Z

[Term]
id: MP:0010635
name: aorta pulmonary collateral arteries
def: "small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus" [PMID:16483787]
subset: CvDC_Terms
synonym: "aorta-pulmonary collateral arteries" EXACT []
synonym: "aortico-pulmonary collateral arteries" EXACT []
synonym: "aorticopulmonary collateral arteries" EXACT []
synonym: "aorto-pulmonary collateral arteries" EXACT []
synonym: "aortopulmonary collateral artery" EXACT []
synonym: "major aorto-pulmonary collateral arteries" EXACT []
synonym: "MAPCAs" EXACT []
synonym: "systemic-pulmonary collateral arteries" EXACT []
xref: Fyler:2770
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0000484 ! abnormal pulmonary artery morphology
is_a: MP:0004007 ! abnormal lung vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T02:22:15Z

[Term]
id: MP:0010636
name: bundle branch block
def: "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8]
synonym: "bundle-branch block" EXACT []
is_a: MP:0010560 ! intraventricular block
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T02:53:36Z

[Term]
id: MP:0010637
name: sinus bradycardia
def: "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:7013
is_a: MP:0005333 ! decreased heart rate
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T03:32:59Z

[Term]
id: MP:0010638
name: absent intercalated disks
def: "absence of the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "absent intercalated discs" EXACT []
is_a: MP:0006267 ! abnormal intercalated disk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-07T04:19:54Z

[Term]
id: MP:0010639
name: abnormal tumor pathology
def: "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal tumour pathology" EXACT []
synonym: "altered neoplasm pathology" BROAD []
synonym: "altered tumor pathology" EXACT []
synonym: "altered tumour pathology" EXACT []
is_a: MP:0002006 ! neoplasm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-08T08:18:43Z

[Term]
id: MP:0010640
name: ventricular myocardium compact layer hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ventricular myocardium compact layer, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "ventricle myocardium compact layer hypoplasia" EXACT []
synonym: "ventricular myocardium compact zone hypoplasia" EXACT []
is_a: MP:0004056 ! abnormal myocardium compact layer morphology
is_a: MP:0010502 ! ventricle myocardium hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-08T02:12:02Z

[Term]
id: MP:0010641
name: descending aorta stenosis
def: "diffuse constriction or narrowing of the descending aorta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009869 ! abnormal descending aorta morphology
is_a: MP:0010463 ! aorta stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T09:34:26Z

[Term]
id: MP:0010642
name: absent third pharyngeal arch
def: "absence of the structure of the third arch which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent third branchial arch" EXACT []
is_a: MP:0003874 ! absent pharyngeal arches
is_a: MP:0006339 ! abnormal third pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T10:09:00Z

[Term]
id: MP:0010643
name: absent fourth pharyngeal arch
def: "absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent fourth branchial arch" EXACT []
is_a: MP:0003874 ! absent pharyngeal arches
is_a: MP:0006340 ! abnormal fourth pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T10:15:42Z

[Term]
id: MP:0010644
name: absent sixth pharyngeal arch
def: "absence of the structure of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent sixth branchial arch" EXACT []
is_a: MP:0003874 ! absent pharyngeal arches
is_a: MP:0006347 ! abnormal sixth pharyngeal arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T10:16:01Z

[Term]
id: MP:0010645
name: failure of conotruncal ridge closure
def: "failure of the conotruncal ridges to develop from the conotruncus, meet at the midline and fuse to form the conotruncal septum" [https://orcid.org/0000-0003-3691-0324]
synonym: "failure of aortico-pulmonary spiral ridge fusion" EXACT []
synonym: "failure of bulbar ridge closure" EXACT []
synonym: "failure of conotruncal ridge fusion" EXACT []
synonym: "failure of endocardial ridge fusion" EXACT []
is_a: MP:0010585 ! abnormal conotruncal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T11:19:07Z

[Term]
id: MP:0010646
name: absent pulmonary vein
def: "absence of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002726 ! abnormal pulmonary vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T11:21:15Z

[Term]
id: MP:0010647
name: heart left atrium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart left atrium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic left atrium" EXACT []
synonym: "left atrial hypoplasia" RELATED []
xref: Fyler:3040
is_a: MP:0004055 ! heart atrium hypoplasia
is_a: MP:0031578 ! decreased heart left atrium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T11:23:01Z

[Term]
id: MP:0010648
name: heart right atrium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the heart right atrium, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "right atrial hypoplasia" EXACT []
is_a: MP:0004055 ! heart atrium hypoplasia
is_a: MP:0031579 ! decreased heart right atrium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T11:23:22Z

[Term]
id: MP:0010649
name: dilated pulmonary trunk
def: "the luminal space of the pulmonary trunk is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated pulmonary trunks" EXACT []
synonym: "pulmonary trunk dilation" EXACT []
is_a: MP:0000486 ! abnormal pulmonary trunk morphology
is_a: MP:0004938 ! dilated vasculature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-12T12:59:44Z

[Term]
id: MP:0010650
name: abnormal aorticopulmonary septum morphology
def: "any structural anomaly of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [ISBN:0-683-40008-8]
synonym: "abnormal aortico-pulmonary spiral septum morphology" EXACT []
synonym: "abnormal aorto-pulmonary septum morphology" EXACT []
synonym: "abnormal aortopulmonary septum morphology" EXACT []
is_a: MP:0006113 ! abnormal heart septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-13T11:38:13Z

[Term]
id: MP:0010651
name: aorticopulmonary septal defect
def: "an abnormal communication in the septum between the aorta and pulmonary artery, resulting from incomplete separation of the common tube of the truncus arteriosus and the aorticopulmonary trunk" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "aortopulmonary septal defect" EXACT []
synonym: "APSD" EXACT []
is_a: MP:0010650 ! abnormal aorticopulmonary septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-13T11:39:49Z

[Term]
id: MP:0010652
name: absent aorticopulmonary septum
def: "absence of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010651 ! aorticopulmonary septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-13T11:44:21Z

[Term]
id: MP:0010653
name: abnormal Wallerian degeneration
def: "any anomaly in the process of progressive degeneration of axons distal to an injury" [PMID:20345246]
synonym: "abnormal anterograde degeneration" EXACT []
synonym: "abnormal orthograde degeneration" EXACT []
is_a: MP:0004811 ! abnormal neuron physiology
is_a: MP:0005164 ! abnormal response to injury
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-13T04:07:55Z

[Term]
id: MP:0010654
name: slow Wallerian degeneration
def: "an increase in the length of time for the process of progressive degeneration of axons distal to an injury to occur" [PMID:20345246]
is_a: MP:0010653 ! abnormal Wallerian degeneration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-13T04:09:22Z

[Term]
id: MP:0010655
name: absent cardiac jelly
def: "absence of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009382 ! abnormal cardiac jelly morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-14T11:14:08Z

[Term]
id: MP:0010656
name: thick myocardium
def: "increased thickness of the heart muscle layer" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005329 ! abnormal myocardium layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-15T03:47:11Z

[Term]
id: MP:0010657
name: absent pulmonary trunk
def: "absence of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000486 ! abnormal pulmonary trunk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-18T03:22:36Z

[Term]
id: MP:0010658
name: thoracic aorta aneurysm
def: "a protruding sac formed by the dilation of the wall of the part of the aorta that extends from the origin at the heart to the diaphragm, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8]
is_a: MP:0006278 ! aortic aneurysm
is_a: MP:0010468 ! abnormal thoracic aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T10:48:18Z

[Term]
id: MP:0010659
name: abdominal aorta aneurysm
def: "a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8]
is_a: MP:0006278 ! aortic aneurysm
is_a: MP:0009870 ! abnormal abdominal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T10:48:39Z

[Term]
id: MP:0010660
name: descending thoracic aorta aneurysm
def: "a protruding sac formed by the dilation of the wall of the of the part of the aorta that extends from the arch of the aorta to the diaphragm, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8]
is_a: MP:0009868 ! abnormal descending thoracic aorta morphology
is_a: MP:0010658 ! thoracic aorta aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T10:50:52Z

[Term]
id: MP:0010661
name: ascending aorta aneurysm
def: "a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:2310
is_a: MP:0009867 ! abnormal ascending aorta morphology
is_a: MP:0010658 ! thoracic aorta aneurysm
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T10:56:31Z

[Term]
id: MP:0010662
name: abnormal intersomitic artery morphology
def: "any structural anomaly of the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal intersegmental artery morphology" EXACT []
synonym: "abnormal somitic artery morphology" EXACT []
is_a: MP:0003410 ! abnormal artery development
is_a: MP:0012253 ! abnormal intersomitic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T11:32:55Z

[Term]
id: MP:0010663
name: abnormal brachiocephalic trunk morphology
def: "any structural anomaly of the short first aortic arch branch which divides into the right subclavian artery and the right common carotid artery" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brachiocephalic artery morphology" EXACT []
synonym: "abnormal innominate artery morphology" EXACT []
is_a: MP:0011655 ! abnormal systemic artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T12:10:18Z

[Term]
id: MP:0010664
name: abnormal vitelline artery morphology
def: "any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal omphalomesenteric artery morphology" EXACT []
is_a: MP:0003229 ! abnormal vitelline vasculature morphology
is_a: MP:0003410 ! abnormal artery development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T03:22:48Z

[Term]
id: MP:0010665
name: persistent vitelline artery
def: "failure of the vitelline arteries to regress and remodel into the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [https://orcid.org/0000-0003-3691-0324]
synonym: "persistent omphalomesenteric artery" EXACT []
is_a: MP:0010664 ! abnormal vitelline artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T03:26:06Z

[Term]
id: MP:0010666
name: abnormal vitelline vein morphology
def: "any structural anomaly of the paired veins that carry blood from the yolk sac back to the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal omphalomesenteric vein morphology" EXACT []
is_a: MP:0003229 ! abnormal vitelline vasculature morphology
is_a: MP:0003411 ! abnormal vein development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T03:38:28Z

[Term]
id: MP:0010667
name: abnormal umbilical vein morphology
def: "any structural anomaly of the vein that returns oxygenated blood from the placenta to the fetus through the umbilical cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003411 ! abnormal vein development
is_a: MP:0012300 ! abnormal umbilical cord blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-19T03:45:54Z

[Term]
id: MP:0010668
name: abnormal hepatic portal vein morphology
def: "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal HPV morphology" EXACT []
synonym: "abnormal portal vein morphology" EXACT []
synonym: "abnormal PV morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T09:31:49Z

[Term]
id: MP:0010669
name: abnormal activation-induced B cell apoptosis
def: "any anomaly in the process in which B cell apoptosis occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
synonym: "abnormal activated B cell apoptosis" EXACT []
synonym: "abnormal activation-induced B-cell apoptosis" EXACT []
synonym: "abnormal activation-induced cell death of B cells" EXACT []
synonym: "abnormal activation-induced cell death of B lymphocytes" EXACT []
synonym: "abnormal activation-induced cell death of B-cells" EXACT []
synonym: "abnormal activation-induced cell death of B-lymphocytes" EXACT []
synonym: "abnormal AICD" BROAD []
synonym: "abnormal antigen-driven apoptosis" BROAD []
xref: GO:0071948
is_a: MP:0008781 ! abnormal B cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T10:46:11Z

[Term]
id: MP:0010670
name: abnormal activation-induced cell death of T cells
def: "any anomaly in the process of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors" [PMID:12752672]
synonym: "abnormal activated T cell apoptosis" EXACT []
synonym: "abnormal activation-induced cell death of T lymphocytes" EXACT []
synonym: "abnormal activation-induced cell death of T-cells" EXACT []
synonym: "abnormal activation-induced cell death of T-lymphocytes" EXACT []
synonym: "abnormal AICD" BROAD []
synonym: "abnormal antigen-driven apoptosis" BROAD []
xref: GO:0006924
is_a: MP:0006412 ! abnormal T cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T10:55:08Z

[Term]
id: MP:0010671
name: abnormal Tc17 cell morphology
def: "any structural anomaly of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg" [CL:0002128, PMID:19201830]
comment: Found in the CD27-positive CD28-positive or CD27-negative CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative.
synonym: "abnormal Tc17 T cell morphology" EXACT []
synonym: "abnormal Tc17 T lymphocyte morphology" EXACT []
synonym: "abnormal Tc17 T-cell morphology" EXACT []
synonym: "abnormal Tc17 T-lymphocyte morphology" EXACT []
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:11:44Z

[Term]
id: MP:0010672
name: increased Tc17 cell number
def: "increased cell number of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg" [CL:0002128, PMID:19201830]
comment: Found in the CD27-positive CD28-positive or CD27-negative CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative.
synonym: "increased Tc17 T cell number" EXACT []
synonym: "increased Tc17 T lymphocyte number" EXACT []
synonym: "increased Tc17 T-cell number" EXACT []
synonym: "increased Tc17 T-lymphocyte number" EXACT []
is_a: MP:0008078 ! increased CD8-positive, alpha-beta T cell number
is_a: MP:0010671 ! abnormal Tc17 cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:16:23Z

[Term]
id: MP:0010673
name: decreased Tc17 cell number
def: "reduced cell number of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg" [CL:0002128, PMID:19201830]
comment: Found in the CD27-positive CD28-positive or CD27-negative CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative.
synonym: "decreased Tc17 T cell number" EXACT []
synonym: "decreased Tc17 T lymphocyte number" EXACT []
synonym: "decreased Tc17 T-cell number" EXACT []
synonym: "decreased Tc17 T-lymphocyte number" EXACT []
synonym: "reduced Tc17 cell number" EXACT []
synonym: "reduced Tc17 T cell number" EXACT []
synonym: "reduced Tc17 T lymphocyte number" EXACT []
synonym: "reduced Tc17 T-cell number" EXACT []
synonym: "reduced Tc17 T-lymphocyte number" EXACT []
is_a: MP:0008079 ! decreased CD8-positive, alpha-beta T cell number
is_a: MP:0010671 ! abnormal Tc17 cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:16:23Z

[Term]
id: MP:0010674
name: increased activation-induced B cell apoptosis
def: "increased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
synonym: "increased activated B cell apoptosis" EXACT []
synonym: "increased activation-induced B-cell apoptosis" EXACT []
synonym: "increased activation-induced cell death of B cells" EXACT []
synonym: "increased activation-induced cell death of B lymphocytes" EXACT []
synonym: "increased activation-induced cell death of B-cells" EXACT []
synonym: "increased activation-induced cell death of B-lymphocytes" EXACT []
synonym: "increased AICD" BROAD []
synonym: "increased antigen-driven apoptosis" BROAD []
xref: GO:0071948
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0010669 ! abnormal activation-induced B cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:53:52Z

[Term]
id: MP:0010675
name: decreased activation-induced B cell apoptosis
def: "decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
synonym: "decreased activated B cell apoptosis" EXACT []
synonym: "decreased activation-induced B-cell apoptosis" EXACT []
synonym: "decreased activation-induced cell death of B cells" EXACT []
synonym: "decreased activation-induced cell death of B lymphocytes" EXACT []
synonym: "decreased activation-induced cell death of B-cells" EXACT []
synonym: "decreased activation-induced cell death of B-lymphocytes" EXACT []
synonym: "decreased AICD" BROAD []
synonym: "decreased antigen-driven apoptosis" BROAD []
synonym: "reduced activated B cell apoptosis" EXACT []
synonym: "reduced activation-induced B cell apoptosis" EXACT []
synonym: "reduced activation-induced B-cell apoptosis" EXACT []
synonym: "reduced activation-induced cell death of B cells" EXACT []
synonym: "reduced activation-induced cell death of B lymphocytes" EXACT []
synonym: "reduced activation-induced cell death of B-cells" EXACT []
synonym: "reduced activation-induced cell death of B-lymphocytes" EXACT []
synonym: "reduced AICD" BROAD []
synonym: "reduced antigen-driven apoptosis" BROAD []
xref: GO:0071948
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0010669 ! abnormal activation-induced B cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:53:52Z

[Term]
id: MP:0010676
name: increased activation-induced cell death of T cells
def: "increased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors" [PMID:12752672]
synonym: "increased activated T cell apoptosis" EXACT []
synonym: "increased activation-induced cell death of T lymphocytes" EXACT []
synonym: "increased activation-induced cell death of T-cells" EXACT []
synonym: "increased activation-induced cell death of T-lymphocytes" EXACT []
synonym: "increased AICD" BROAD []
synonym: "increased antigen-driven apoptosis" BROAD []
xref: GO:0006924
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0010670 ! abnormal activation-induced cell death of T cells
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:55:01Z

[Term]
id: MP:0010677
name: decreased activation-induced cell death of T cells
def: "decreased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors" [PMID:12752672]
synonym: "decreased activated T cell apoptosis" EXACT []
synonym: "decreased activation-induced cell death of T lymphocytes" EXACT []
synonym: "decreased activation-induced cell death of T-cells" EXACT []
synonym: "decreased activation-induced cell death of T-lymphocytes" EXACT []
synonym: "decreased AICD" BROAD []
synonym: "decreased antigen-driven apoptosis" BROAD []
synonym: "reduced activated T cell apoptosis" EXACT []
synonym: "reduced activation-induced cell death of T cells" EXACT []
synonym: "reduced activation-induced cell death of T lymphocytes" EXACT []
synonym: "reduced activation-induced cell death of T-cells" EXACT []
synonym: "reduced activation-induced cell death of T-lymphocytes" EXACT []
synonym: "reduced AICD" BROAD []
synonym: "reduced antigen-driven apoptosis" BROAD []
xref: GO:0006924
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0010670 ! abnormal activation-induced cell death of T cells
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T11:55:01Z

[Term]
id: MP:0010678
name: abnormal skin adnexa morphology
def: "any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skin accessory structure morphology" EXACT []
synonym: "abnormal skin appendage morphology" EXACT []
is_a: MP:0010771 ! integument phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T12:27:31Z

[Term]
id: MP:0010679
name: abnormal arrector pilli muscle morphology
def: "any structural anomaly of the bundles of smooth muscle fibers that connect the hair follicle with the papillary layer of the dermis, and serve to pull hair shafts erect" [PMID:19211055]
synonym: "abnormal arrector mucle of hair" EXACT []
synonym: "abnormal errector muscle of hair" EXACT []
synonym: "abnormal errector pilli muscle" EXACT []
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0030572 ! abnormal pilosebaceous unit morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T12:37:40Z

[Term]
id: MP:0010680
name: abnormal skin adnexa physiology
def: "any functional anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal skin accessory structure physiology" EXACT []
synonym: "abnormal skin appendage physiology" EXACT []
is_a: MP:0010771 ! integument phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T12:45:35Z

[Term]
id: MP:0010681
name: abnormal hair follicle bulb morphology
def: "any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells" [PMID:19211055]
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T12:58:46Z

[Term]
id: MP:0010682
name: abnormal hair follicle infundibulum morphology
def: "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
synonym: "abnormal dermal pilary canal morphology" EXACT [PMID:20882038, PMID:29056331]
synonym: "abnormal dermal piliary canal morphology" EXACT [UBERON:0005968]
synonym: "abnormal hair follicle upper segment morphology" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T01:04:57Z

[Term]
id: MP:0010683
name: dilated hair follicle infundibulum
def: "the luminal space of one or more hair follicle infundibuli is increased in volume or area, sometimes with an increase of contained fluid or sebum" [https://orcid.org/0000-0003-3691-0324]
synonym: "dermal pilary canal dilation" EXACT []
synonym: "dermal piliary canal dilation" EXACT []
synonym: "dilated dermal pilary canal" EXACT []
synonym: "dilated dermal pilary canals" EXACT []
synonym: "dilated dermal piliary canal" EXACT []
synonym: "dilated dermal piliary canals" EXACT []
synonym: "dilated hair follicle infundibuli" EXACT []
synonym: "hair follicle infundibulum dilation" EXACT []
is_a: MP:0010682 ! abnormal hair follicle infundibulum morphology
is_a: MP:0010699 ! dilated hair follicle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T01:06:46Z

[Term]
id: MP:0010684
name: abnormal hair follicle outer root sheath morphology
def: "any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]
synonym: "abnormal hair follicle epidermal root sheath morphology" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T01:25:08Z

[Term]
id: MP:0010685
name: abnormal hair follicle inner root sheath morphology
def: "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle" [PMID:19211055]
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T01:25:34Z

[Term]
id: MP:0010686
name: abnormal hair follicle matrix region morphology
def: "any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]
is_a: MP:0010681 ! abnormal hair follicle bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T01:29:34Z

[Term]
id: MP:0010687
name: absent hair follicle dermal papilla
def: "absence of the mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts" [PMID:19211055]
is_a: MP:0003813 ! abnormal hair follicle dermal papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T02:43:06Z

[Term]
id: MP:0010688
name: hair follicle outer root sheath hyperplasia
def: "increase in the number of normal cells in normal arrangement in the hair follicle outer root sheath, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hair follicle epidermal root sheath hyperplasia" EXACT []
synonym: "hyperplastic hair follicle outer root sheath" EXACT []
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:16:08Z

[Term]
id: MP:0010689
name: thin hair follicle outer root sheath
def: "reduced thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [https://orcid.org/0000-0003-3691-0324]
synonym: "thin hair follicle epidermal root sheath" EXACT []
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:16:57Z

[Term]
id: MP:0010690
name: thick hair follicle outer root sheath
def: "increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick hair follicle epidermal root sheath" EXACT []
is_a: MP:0010684 ! abnormal hair follicle outer root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:16:57Z

[Term]
id: MP:0010691
name: hair follicle inner root sheath hyperplasia
def: "increase in the number of normal cells in normal arrangement in the hair follicle inner root sheath, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic hait follicle inner root sheath" EXACT []
is_a: MP:0010685 ! abnormal hair follicle inner root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:17:44Z

[Term]
id: MP:0010692
name: thick hair follicle inner root sheath
def: "increased thickness of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010685 ! abnormal hair follicle inner root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:17:44Z

[Term]
id: MP:0010693
name: thin hair follicle inner root sheath
def: "reduced thickness of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010685 ! abnormal hair follicle inner root sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:17:44Z

[Term]
id: MP:0010694
name: abnormal hair follicle isthmus morphology
def: "any structural anomaly of the middle part of the hair follicle that extends from the sebaceous duct to the bulge" [PMID:19211055]
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:23:41Z

[Term]
id: MP:0010695
name: abnormal blood pressure regulation
def: "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]
synonym: "abnormal blood pressure homeostasis" EXACT []
synonym: "abnormal control of blood pressure" EXACT []
synonym: "abnormal regulation of blood pressure" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:45:01Z

[Term]
id: MP:0010696
name: increased siderocyte number
def: "the presence of abnormal red blood cells that have iron granule deposits that are not part of the hemoglobin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:48:30Z

[Term]
id: MP:0010697
name: abnormal systemic arterial blood pressure regulation
def: "anomaly in the process that modulates the force with which blood travels through the systemic arterial circulatory system" [GO:0003073]
is_a: MP:0010695 ! abnormal blood pressure regulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T03:51:25Z

[Term]
id: MP:0010698
name: abnormal impulsive behavior control
def: "any anomaly in the ability of an individual to exert restraint over behavior" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal impulsive behaviour control" EXACT []
synonym: "abnormal impulsivity" EXACT []
synonym: "behavioral disinhibition" EXACT []
synonym: "behavioural disinhibition" EXACT []
is_a: MP:0004924 ! abnormal behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-20T04:16:12Z

[Term]
id: MP:0010699
name: dilated hair follicle
alt_id: MP:0000385
def: "the luminal space of one or more of the hair follicles is increased in volume or area, sometimes with an increase of contained fluid or sebum" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated hair follicles" EXACT []
synonym: "distended hair follicle" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "distended hair follicles" EXACT []
synonym: "hair follicle dilation" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-21T10:40:05Z

[Term]
id: MP:0010700
name: hair follicle comedo
def: "a dilated or widened hair follicle filled with keratin squamae (skin debris), bacteria, and/or sebum (oil)" [http://www.medterms.com]
synonym: "blackhead" NARROW []
synonym: "hair follicle comedones" EXACT []
synonym: "whitehead" NARROW []
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-21T10:55:28Z

[Term]
id: MP:0010701
name: fusion of atlas and odontoid process
def: "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [https://orcid.org/0000-0003-3691-0324]
synonym: "atlas and odontoid process fusion" EXACT []
synonym: "C1 anterior arch and dens fusion" EXACT []
synonym: "fused atlas and odontoid process" EXACT []
synonym: "fusion of AA and dens" EXACT []
is_a: MP:0004607 ! abnormal cervical atlas morphology
is_a: MP:0004620 ! cervical vertebral fusion
is_a: MP:0004659 ! abnormal odontoid process morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T11:38:18Z

[Term]
id: MP:0010702
name: split cervical atlas
def: "the first (topmost, C1) cervical vertebra is divided into two branches by a median cleft" [https://orcid.org/0000-0003-3691-0324]
synonym: "bifid atlas" EXACT []
synonym: "C1 bifid" EXACT []
is_a: MP:0004607 ! abnormal cervical atlas morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T11:55:16Z

[Term]
id: MP:0010703
name: split cervical axis
def: "the second cervical vertebra (C2) is divided into two branches by a median cleft" [https://orcid.org/0000-0003-3691-0324]
synonym: "bifid axis" EXACT []
synonym: "C2 bifid" EXACT []
is_a: MP:0004608 ! abnormal cervical axis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T11:57:04Z

[Term]
id: MP:0010704
name: abnormal optic canal morphology
def: "any structural anomaly of the short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the ophthalmic artery; the optic foramen is the opening to the optic canal" [https://en.wikipedia.org/wiki/Optic_canal, ISBN:0-683-40008-8]
synonym: "abnormal optic foramen morphology" EXACT []
is_a: MP:0004457 ! abnormal orbitosphenoid bone morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T01:51:33Z

[Term]
id: MP:0010705
name: absent metoptic pillar
def: "absence of the posterior border of the optic nerve foramen" [PMID:11493527]
synonym: "agenesis of the metoptic pilar" EXACT []
synonym: "metoptic pilar agenesis" EXACT []
is_a: MP:0010704 ! abnormal optic canal morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T02:05:04Z

[Term]
id: MP:0010706
name: ventral rotation of lens
def: "a circular shift toward the ventral pole in the position of the equator of the lens relative to the optic nerve exit point" [PMID:7923367]
is_a: MP:0001308 ! abnormal lens polarity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T02:17:27Z

[Term]
id: MP:0010707
name: decreased ventral retina size
def: "decreasd size of the ventral portion of the retina" [https://orcid.org/0000-0003-3691-0324, PMID:7923367]
synonym: "short ventral retina" EXACT []
synonym: "small ventral retina" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T02:31:14Z

[Term]
id: MP:0010708
name: absent iris stroma
def: "absence of the lamellated vascular connective tissue of the iris" [ISBN:0-683-40008-8]
synonym: "agenesis of iris stroma" EXACT []
synonym: "iris stroma agenesis" EXACT []
is_a: MP:0005208 ! abnormal iris stroma morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:02:33Z

[Term]
id: MP:0010709
name: absent eye anterior chamber
def: "absence of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067]
is_a: MP:0005205 ! abnormal eye anterior chamber morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:03:52Z

[Term]
id: MP:0010710
name: absent sclera
def: "absence of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea" [MESH:A09.371.784]
synonym: "absent sclerotic coat" EXACT []
synonym: "absent tunica sclerotica" EXACT []
synonym: "agenesis of the sclera" EXACT []
synonym: "sclera agenesis" EXACT []
is_a: MP:0002698 ! abnormal sclera morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:05:29Z

[Term]
id: MP:0010711
name: persistent hyperplastic primary vitreous
def: "persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [https://orcid.org/0000-0003-3691-0324]
synonym: "persistent hyperplasia of primary vitreous" EXACT []
synonym: "PHPV" RELATED []
synonym: "retrolenticular membrane" EXACT []
is_a: MP:0009620 ! abnormal primary vitreous morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:09:04Z

[Term]
id: MP:0010712
name: absent nasolacrimal duct
def: "absence of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity" [ISBN:0-683-40008-8]
synonym: "absent nasal duct" EXACT []
synonym: "absent naso-lacrimal duct" EXACT []
is_a: MP:0008969 ! abnormal nasolacrimal duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:26:40Z

[Term]
id: MP:0010713
name: corneal-lenticular stalk
def: "persistent central adhesion between the lens and the cornea" [PMID:18653562]
synonym: "central corneal adhesion to lens" EXACT []
synonym: "corneal-lens adhesions" EXACT []
is_a: MP:0001303 ! abnormal lens morphology
is_a: MP:0001312 ! abnormal cornea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:31:39Z

[Term]
id: MP:0010714
name: iris coloboma
def: "congenital defect of the iris in which some part of the structure is absent" [https://orcid.org/0000-0003-3691-0324]
synonym: "coloboma iridis" EXACT []
synonym: "coloboma of the iris" EXACT []
synonym: "iridodiastasis" NARROW []
is_a: MP:0001322 ! abnormal iris morphology
is_a: MP:0012533 ! uveal coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:42:03Z

[Term]
id: MP:0010715
name: retina coloboma
def: "congenital defect of the retina in which some part of the structure is absent" [https://orcid.org/0000-0003-3691-0324]
synonym: "coloboma of the retina" EXACT []
synonym: "retinal coloboma" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
is_a: MP:0005262 ! coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:43:32Z

[Term]
id: MP:0010716
name: optic disk coloboma
def: "congenital defect of the optic disk in which some part of the structure is absent" [https://orcid.org/0000-0003-3691-0324]
synonym: "coloboma of the optic disc" EXACT []
synonym: "ODC" EXACT []
synonym: "optic disc coloboma" EXACT []
is_a: MP:0005262 ! coloboma
is_a: MP:0008259 ! abnormal optic disk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:43:48Z

[Term]
id: MP:0010717
name: optic nerve coloboma
def: "congenital defect of the optic nerve in which some part of the structure is absent" [https://orcid.org/0000-0003-3691-0324]
synonym: "coloboma of the optic nerve" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology
is_a: MP:0005262 ! coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:44:14Z

[Term]
id: MP:0010718
name: choroid coloboma
def: "congenital defect of the choroid and retinal pigment epithelium in which some part of the structures are absent, exposing the sclera; the defect is usually situated below the optic disk in the region of fetal (choroid) fissure" [ISBN:0-683-40008-8]
synonym: "choroidal coloboma" EXACT []
synonym: "coloboma of the choroid" EXACT []
is_a: MP:0005098 ! abnormal optic choroid morphology
is_a: MP:0012533 ! uveal coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:45:03Z

[Term]
id: MP:0010719
name: ciliary body coloboma
def: "congenital defect of the ciliary body in which some part of the structure is absent" [https://orcid.org/0000-0003-3691-0324]
synonym: "coloboma of the ciliary body" EXACT []
is_a: MP:0005099 ! abnormal ciliary body morphology
is_a: MP:0012533 ! uveal coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T03:59:36Z

[Term]
id: MP:0010720
name: absent sublingual duct
def: "absence of the canals that drain the sublingual gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "agenesis of sublingual duct" RELATED []
synonym: "sublingual duct agenesis" EXACT []
is_a: MP:0009527 ! abnormal sublingual duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T04:07:46Z

[Term]
id: MP:0010721
name: short sublingual duct
def: "decreased length of the canals that drain the sublingual gland" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased sublingual gland length" EXACT []
is_a: MP:0009527 ! abnormal sublingual duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T04:09:06Z

[Term]
id: MP:0010722
name: persistent cervical thymus
def: "the solid lobe of the thymus fails to descend to the mediastinum" [https://orcid.org/0000-0003-3691-0324]
synonym: "remnant cervical thymus" RELATED []
synonym: "undescended cervical thymus" EXACT []
is_a: MP:0000704 ! abnormal thymus development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-22T04:12:07Z

[Term]
id: MP:0010723
name: paternal effect
def: "expression of a phenotypic trait in a male animal's offspring that is dependent on the paternal genotype" [MGI:llw2]
comment: Temporary. This is a term that describes the expression of a phenotype, not the phenotype itself.
is_a: MP:0005384 ! cellular phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-26T09:36:27Z

[Term]
id: MP:0010724
name: thick interventricular septum
def: "increased thickness of the wall between the two lower chambers of the heart" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0020136 ! abnormal interventricular septum thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-26T01:11:57Z

[Term]
id: MP:0010725
name: thin interventricular septum
def: "decreased thickness of the wall between the two lower chambers of the heart" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0020136 ! abnormal interventricular septum thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-10-26T01:12:13Z

[Term]
id: MP:0010726
name: abnormal collateral sprouting
def: "aberrant response of a neuron to form new neuritic processes (sprouts) that emerge from the nerve fibers or terminal arborizations in response to nerve injury (such as section or denervation), application of neurotoxin, or target tissue atrophy (usually due to disease)" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal neuron collateral sprouting" RELATED []
is_a: MP:0004811 ! abnormal neuron physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-02T10:06:03Z

[Term]
id: MP:0010727
name: increased glioblastoma incidence
def: "greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698]
synonym: "increased GBM incidence" NARROW []
synonym: "increased glioblastoma multiforme incidence" NARROW []
synonym: "increased grade IV astrocytoma incidence" EXACT []
is_a: MP:0008021 ! increased blastoma incidence
is_a: MP:0010278 ! increased glioma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-03T01:21:12Z

[Term]
id: MP:0010728
name: fusion of atlas and occipital bones
def: "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "atlas and occipital bone fusion" EXACT []
synonym: "fused atlas and occipital bones" EXACT []
is_a: MP:0004607 ! abnormal cervical atlas morphology
is_a: MP:0005269 ! abnormal occipital bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-08T12:22:15Z

[Term]
id: MP:0010729
name: absent arcus anterior
def: "absence of the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8, MGI:llw2]
synonym: "absent anterior arch" EXACT []
synonym: "absent arcus anterior atlantis" EXACT []
is_a: MP:0009879 ! abnormal arcus anterior morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-08T12:30:26Z

[Term]
id: MP:0010730
name: absent odontoid process
def: "absence of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8]
is_a: MP:0004659 ! abnormal odontoid process morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-08T02:20:56Z

[Term]
id: MP:0010731
name: absent ventral tubercle of atlas
def: "absence of the conical ventral projection on the arch of the atlas" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004658 ! abnormal ventral tubercle of atlas morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-08T02:27:23Z

[Term]
id: MP:0010732
name: abnormal node of Ranvier morphology
def: "any structural anomaly of the short unmyelinated segments of an axon between myelinated segments, where voltage gated channels accumulate and regenerate an action potential as it is conducted along the axon" [PMID:18929652]
synonym: "abnormal node" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-09T01:51:31Z

[Term]
id: MP:0010733
name: abnormal axon initial segment morphology
def: "any structural anomaly of the short unmyelinated axon segment adjacent to the cell soma where voltage gated channels accumulate and axon potential initiation usually occurs" [PMID:18929652]
synonym: "abnormal AIS morphology" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-09T01:55:49Z

[Term]
id: MP:0010734
name: abnormal paranode morphology
def: "any structural anomaly of the axon region immediately adjacent to nodes of Ranvier, where a series of cytoplasmic loops from the overlying glial cell form septate-like junctions with the axon; the axoglial junctions act as a diffusion barrier between the node and internode" [PMID:16224497]
synonym: "abnormal axon paranodal region morphology" EXACT []
synonym: "abnormal axon paranode morphology" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-09T01:55:49Z

[Term]
id: MP:0010735
name: abnormal paranodal axoglial junction morphology
def: "any structural anomaly of the structure in which the myelin sheath attaches to the axon at each end of each myelin segment; the axoglial junctions act as a diffusion barrier between the node and internode, maintaining domain-specific axolemmal membrane components" [PMID:19224642]
synonym: "abnormal axoglial septate junction" EXACT []
synonym: "abnormal paranodal septate junction morphology" EXACT []
synonym: "abnormal PNJ" EXACT []
is_a: MP:0010734 ! abnormal paranode morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-09T01:55:49Z

[Term]
id: MP:0010736
name: abnormal extraembryonic ectoderm morphology
def: "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-09T04:26:12Z

[Term]
id: MP:0010737
name: abnormal juxtaparanode morphology
def: "any structural anomaly of the region of an axon near a node of Ranvier that is between the paranode axoglial junction and the internode regions; the juxtaparanode axolemma is enriched in potassium channels" [PMID:18803321]
synonym: "abnormal juxtaparanodal region morphology" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-10T10:50:26Z

[Term]
id: MP:0010738
name: abnormal internode morphology
def: "any structural anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath" [PMID:18929652]
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-10T10:50:49Z

[Term]
id: MP:0010739
name: abnormal axolemma morphology
def: "any structural anomaly of the plasma membrane of an axon" [ISBN:0-683-40008-8]
synonym: "abnormal axon plasma membrane morphology" EXACT []
synonym: "abnormal axonal membrane morphology" EXACT []
synonym: "abnormal Mauthner sheath morphology" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-10T12:00:22Z

[Term]
id: MP:0010740
name: abnormal dendritic cell chemotaxis
def: "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
is_a: MP:0011518 ! abnormal cell chemotaxis
is_a: MP:0020349 ! abnormal dendritic cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T03:24:21Z

[Term]
id: MP:0010741
name: abnormal melanocyte proliferation
def: "anomaly in the ability of a melanocyte cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0001186 ! pigmentation phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T03:57:15Z

[Term]
id: MP:0010742
name: increased Schwann cell number
def: "greater than normal number of cells that sheath the axons of the peripheral nervous system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001106 ! abnormal Schwann cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T04:01:57Z

[Term]
id: MP:0010743
name: delayed cranial suture closure
def: "late onset of closure of one or more of the joints (sutures) between the bones of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed fusion of cranial sutures" EXACT []
synonym: "delayed suture closure" EXACT []
is_a: MP:0003420 ! delayed intramembranous bone ossification
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T04:04:28Z

[Term]
id: MP:0010744
name: abnormal cervical flexure morphology
def: "any structural anomaly in the ventrally concave flexure of the embryonic brain occurring at the junction of hindbrain and spinal cord" [ISBN:0-12-402035-6]
is_a: MP:0000913 ! abnormal brain development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T04:07:32Z

[Term]
id: MP:0010745
name: abnormal pre-Botzinger complex morphology
def: "any structural anomaly of the group of interneurons within the medulla oblongata's ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
is_a: MP:0000846 ! abnormal medulla oblongata morphology
is_a: MP:0001033 ! abnormal parasympathetic system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T04:23:51Z

[Term]
id: MP:0010746
name: abnormal pre-Botzinger complex physiology
def: "any functional anomaly of the group of interneurons within the medulla oblongata's ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
is_a: MP:0003880 ! abnormal central pattern generator function
is_a: MP:0006277 ! abnormal parasympathetic nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-11T04:36:35Z

[Term]
id: MP:0010747
name: abnormal enamel organ morphology
def: "any structural anomaly of the circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth" [ISBN:0-683-40008-8]
synonym: "abnormal dental organ morphology" EXACT []
is_a: MP:0000116 ! abnormal tooth development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-12T03:15:22Z

[Term]
id: MP:0010748
name: abnormal visual evoked potential
def: "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal vision evoked potentials" EXACT []
synonym: "abnormal visual evoked response" EXACT []
synonym: "abnormal visually evoked potential" EXACT []
is_a: MP:0005551 ! abnormal eye electrophysiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-12T03:55:48Z

[Term]
id: MP:0010749
name: absent visual evoked potential
def: "absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent vision evoked potentials" EXACT []
synonym: "absent visual evoked response" EXACT []
synonym: "absent visually evoked potential" EXACT []
is_a: MP:0010748 ! abnormal visual evoked potential
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-12T03:57:03Z

[Term]
id: MP:0010750
name: increased susceptibility to parasitic infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased resistance to parasitic infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to parasitic infection induced morbidity/mortality" EXACT []
synonym: "increased susceptibility to parasite infection induced morbidity/mortality" EXACT []
is_a: MP:0005027 ! increased susceptibility to parasitic infection
is_a: MP:0009787 ! increased susceptibility to infection induced morbidity/mortality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-12T04:06:04Z

[Term]
id: MP:0010751
name: decreased susceptibility to parasitic infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sensitivity to parasitic infection induced morbidity/mortality" EXACT []
synonym: "decreased susceptibility to parasite infection induced morbidity/mortality" EXACT []
synonym: "increased resistance to parasitic infection induced morbidity/mortality" EXACT []
is_a: MP:0005026 ! decreased susceptibility to parasitic infection
is_a: MP:0009786 ! decreased susceptibility to infection induced morbidity/mortality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-11-12T04:07:02Z

[Term]
id: MP:0010752
name: impaired mucociliary clearance
def: "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [https://orcid.org/0000-0003-3691-0324, MESH:E01.370.386.520]
is_a: MP:0001947 ! abnormal mucociliary clearance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T11:40:59Z

[Term]
id: MP:0010753
name: improved mucociliary clearance
def: "enhanced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [https://orcid.org/0000-0003-3691-0324, MESH:E01.370.386.520]
is_a: MP:0001947 ! abnormal mucociliary clearance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T11:41:22Z

[Term]
id: MP:0010754
name: abnormal heart left ventricle pressure
def: "any anomaly in the pressure within the left cardiac ventricle" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal heart left ventricular pressure" EXACT []
is_a: MP:0008775 ! abnormal heart ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:21:58Z

[Term]
id: MP:0010755
name: abnormal heart right ventricle pressure
def: "any anomaly in the pressure within the right cardiac ventricle" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal heart right ventricular pressure" EXACT []
is_a: MP:0008775 ! abnormal heart ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:23:06Z

[Term]
id: MP:0010756
name: decreased right ventricle peak pressure
def: "decrease in the difference between right ventricular systolic and diastolic pressures" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased right ventricular peak pressure" EXACT []
synonym: "reduced right ventricle peak pressure" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:45:04Z

[Term]
id: MP:0010757
name: decreased right ventricle diastolic pressure
def: "decrease in the pressure of the right ventricle between heart beats when the heart is relaxed" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased right ventricular diastolic pressure" EXACT []
synonym: "decreased RVP" EXACT []
synonym: "reduced right ventricle diastolic pressure" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:45:04Z

[Term]
id: MP:0010758
name: increased right ventricle systolic pressure
def: "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased right ventricular systolic pressure" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:45:04Z

[Term]
id: MP:0010759
name: decreased right ventricle systolic pressure
def: "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased right ventricular systolic pressure" EXACT []
synonym: "reduced right ventricle systolic pressure" EXACT []
is_a: MP:0010755 ! abnormal heart right ventricle pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T01:45:04Z

[Term]
id: MP:0010760
name: abnormal macrophage chemotaxis
alt_id: MP:0005495
def: "anomaly in the accumulation of macrophages in a specific location in response to a wide variety of substances released at the sites of inflammatory reactions" [GO:0048246]
synonym: "abnormal macrophage migration" RELATED []
synonym: "abnormal macrophage recruitment" EXACT []
is_a: MP:0002451 ! abnormal macrophage physiology
is_a: MP:0003156 ! abnormal leukocyte migration
is_a: MP:0011518 ! abnormal cell chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T02:44:10Z

[Term]
id: MP:0010761
name: abnormal microglial cell chemotaxis
def: "anomaly in the movement of a microglial cell guided by a specific chemical concentration gradient" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal microglial cell migration" EXACT []
synonym: "abnormal microglial cell recruitment" NARROW []
is_a: MP:0003691 ! abnormal microglial cell physiology
is_a: MP:0010760 ! abnormal macrophage chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T02:46:55Z

[Term]
id: MP:0010762
name: abnormal microglial cell activation
def: "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003691 ! abnormal microglial cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T03:38:16Z

[Term]
id: MP:0010763
name: abnormal hematopoietic stem cell physiology
def: "any functional anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal haematopoietic progenitor cell physiology" EXACT []
synonym: "abnormal haematopoietic stem cell physiology" EXACT []
synonym: "abnormal haemopoietic progenitor cell physiology" EXACT []
synonym: "abnormal hematopoietic progenitor cell physiology" EXACT []
synonym: "abnormal hemopoietic progenitor cell physiology" EXACT []
synonym: "abnormal HSC physiology" EXACT []
is_a: MP:0001545 ! abnormal hematopoietic system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-09T03:49:30Z

[Term]
id: MP:0010764
name: abnormal granulocyte chemotaxis
def: "anomaly in the movement of a granulocyte guided by a specific chemical concentration gradient" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002462 ! abnormal granulocyte physiology
is_a: MP:0011518 ! abnormal cell chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-10T09:48:29Z

[Term]
id: MP:0010765
name: impaired granulocyte chemotaxis
alt_id: MP:0005073
def: "reduced ability in the movement of a granulocyte guided by a specific chemical concentration gradient" [https://orcid.org/0000-0003-3691-0324]
synonym: "defective granulocyte chemotaxis" EXACT []
synonym: "impaired granulocyte migration" BROAD []
is_a: MP:0010764 ! abnormal granulocyte chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-10T09:59:45Z

[Term]
id: MP:0010766
name: abnormal NK cell physiology
alt_id: MP:0005069
def: "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, https://orcid.org/0000-0003-3691-0324, ISBN:0781735149, PMID:15771571]
synonym: "abnormal natural killer cell physiology" EXACT []
synonym: "dysfunctional NK cells" EXACT []
synonym: "natural killer cell dysfunction" EXACT []
synonym: "NK cell dysfunction" EXACT []
xref: CL:0000623
xref: FMA:63147
xref: FMA:83601
is_a: MP:0002419 ! abnormal innate immunity
is_a: MP:0003945 ! abnormal lymphocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-10T11:34:06Z

[Term]
id: MP:0010767
name: abnormal female meiosis I arrest
def: "any anomaly in the process in which oocytes stop at the diplotene stage of meiosis I and lie dormant, often for long periods of time" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal dictyotene stage" EXACT []
is_a: MP:0005168 ! abnormal female meiosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2010-12-10T02:07:10Z

[Term]
id: MP:0010768
name: mortality/aging
alt_id: MP:0005372
alt_id: MP:0005373
alt_id: MP:0005374
def: "the observable characteristics related to the ability of a mammalian organism to live and age that are manifested throughout development and life span" [https://orcid.org/0000-0003-3691-0324]
synonym: "lethality-embryonic/perinatal" NARROW []
synonym: "lethality-postnatal" NARROW []
synonym: "lethality-prenatal/perinatal" NARROW []
synonym: "life span-post-weaning/aging" NARROW []
synonym: "lifespan" RELATED []
synonym: "mortality/ageing" EXACT []
synonym: "survival" RELATED []
is_a: MP:0000001 ! mammalian phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-07T09:57:14Z

[Term]
id: MP:0010769
name: abnormal survival
def: "deviation from the expected viability or life span of an organism" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal life span" NARROW []
synonym: "lethality" EXACT []
is_a: MP:0010768 ! mortality/aging
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-07T10:07:26Z

[Term]
id: MP:0010770
name: preweaning lethality
def: "death anytime between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [https://orcid.org/0000-0002-8404-2907]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0010769 ! abnormal survival
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-07T11:39:57Z

[Term]
id: MP:0010771
name: integument phenotype
alt_id: MP:0005392
alt_id: MP:0005393
def: "the observable morphological and physiological characteristics of the skin and its associated structures, such as the hair, nails, sweat glands, sebaceous glands and other secretory glands that are manifested through development and lifespan" [https://orcid.org/0000-0003-3691-0324]
subset: Sanger_Terms
synonym: "skin/coat/nails phenotype" NARROW []
synonym: "touch/vibrissae phenotype" NARROW []
is_a: MP:0000001 ! mammalian phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-11T12:31:48Z

[Term]
id: MP:0010772
name: abnormal pollex morphology
def: "any structural anomaly of the first or primary digit on the radial side of the hand" [ISBN:0-683-40008-8]
synonym: "abnormal digitus primus morphology" BROAD []
synonym: "abnormal thumb morphology" EXACT []
is_a: MP:0002110 ! abnormal digit morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-25T10:43:26Z

[Term]
id: MP:0010773
name: supernumerary molars
def: "increased number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:llw2]
synonym: "increased molar number" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0004033 ! supernumerary teeth
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-26T03:55:05Z

[Term]
id: MP:0010774
name: abnormal lymph node follicular mantle morphology
def: "any structural anomaly of the part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it" [PMID:11905817]
synonym: "abnormal lymph node follicular corona morphology" EXACT []
xref: MA:0002990
is_a: MP:0002346 ! abnormal lymph node secondary follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-27T11:51:22Z

[Term]
id: MP:0010775
name: abnormal scaphoid morphology
def: "any structural anomaly of the bone of the hand located at the radial side of the carpus and which articulates with the radius, trapezium, trapezoideum, capitate, and lunate bones" [MGI:llw2]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal navicular of hand morphology" EXACT []
synonym: "abnormal radial carpal bone morphology" EXACT []
xref: MA:0002555
is_a: MP:0000554 ! abnormal carpal bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-27T01:35:36Z

[Term]
id: MP:0010776
name: abnormal placenta metrial gland morphology
def: "any structural anomaly in the group of granular epithelial cells in the uterine muscle beneath the placenta that develops during pregnancy in rodents and some other species, but not in primates" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal granulated metrial gland" EXACT []
synonym: "abnormal placental metrial gland" EXACT []
xref: MA:0000386
is_a: MP:0004256 ! abnormal maternal decidual layer morphology
is_a: MP:0013324 ! abnormal female reproductive gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-27T02:26:18Z

[Term]
id: MP:0010777
name: absent placenta metrial gland
def: "absence of the group of granular epithelial cells in the uterine muscle beneath the placenta that develops during pregnancy in rodents and some other species, but not in primates" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent placental metrial gland" EXACT []
is_a: MP:0010776 ! abnormal placenta metrial gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-01-27T02:45:02Z

[Term]
id: MP:0010778
name: abnormal stomach fundus morphology
def: "any structural anomaly of the region of the stomach that lies above the cardiac notch that functions to store undigested food and to collect stomach gases produced by chemical digestion" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal gastric fundus morphology" EXACT []
synonym: "abnormal stomach greater cul-de-sac morphology" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T10:58:04Z

[Term]
id: MP:0010779
name: abnormal stomach muscularis externa morphology
def: "any structural anomaly of the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gastric muscularis morphology" EXACT []
synonym: "abnormal gastric smooth muscle morphology" EXACT []
synonym: "abnormal muscularis externa morphology" EXACT []
synonym: "abnormal stomach smooth muscle morphology" BROAD []
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0010783 ! abnormal stomach wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:01:17Z

[Term]
id: MP:0010780
name: abnormal stomach smooth muscle circular layer morphology
def: "any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010779 ! abnormal stomach muscularis externa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:01:35Z

[Term]
id: MP:0010781
name: pyloric sphincter hypertrophy
def: "increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids" [ISBN:0-683-40008-8]
is_a: MP:0009861 ! abnormal pyloric sphincter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:03:42Z

[Term]
id: MP:0010782
name: stomach smooth muscle circular layer hypertrophy
def: "increase in the bulk size of the middle layer of the muscularis due to cell enlargement or accumulation of fluids" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010780 ! abnormal stomach smooth muscle circular layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:04:16Z

[Term]
id: MP:0010783
name: abnormal stomach wall morphology
def: "any structural anomaly of the layered structure that makes up the stomach, consisting of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:04:49Z

[Term]
id: MP:0010784
name: abnormal forestomach morphology
def: "any structural anomaly of the distinct rodent non-glandular region of the stomach which is demarcated from the glandular stomach by the limiting ridge (margo plicatus); the forestomach accounts for about 60% (rat) and 70% (mouse) of the stomach volume and receives the esophagus at the cardiac antrum; the wall of the forestomach consists of, from inside to outside, stratified squamous epithelium, the lamina propria (epithelium and lamina propria form the mucosa), the muscularis mucosae, the submucosa, the muscularis interna and externa (inner circular and outer longitudinal layers of smooth muscle), and the serosa" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/forestomach.html, https://orcid.org/0000-0002-6490-7723, ISBN:0849366887]
comment: The forestomach is not present in humans.
synonym: "abnormal anterior stomach morphology" EXACT []
synonym: "abnormal antrum cardiacum morphology" EXACT []
synonym: "abnormal non-glandular stomach morphology" EXACT []
synonym: "abnormal proximal stomach morphology" EXACT []
synonym: "abnormal stomach cardiac antrum morphology" EXACT []
synonym: "abnormal stomach non-glandular region morphology" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:05:59Z

[Term]
id: MP:0010785
name: abnormal stomach pyloric region morphology
def: "any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal stomach pylorus morphology" RELATED []
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:06:53Z

[Term]
id: MP:0010786
name: stomach fundus hypertrophy
def: "increase in the bulk size of the stomach fundus due to cell enlargement or accumulation of fluids" [https://orcid.org/0000-0003-3691-0324]
synonym: "gastric fundus hypertrophy" EXACT []
is_a: MP:0010778 ! abnormal stomach fundus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:09:14Z

[Term]
id: MP:0010787
name: gastric cyst
def: "presence of one or more abnormal membranous sacs in the wall of the stomach" [https://orcid.org/0000-0003-3691-0324]
synonym: "cystic stomach" EXACT []
synonym: "gastric cysts" EXACT []
synonym: "stomach cyst" EXACT []
synonym: "stomach cysts" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0031310 ! abnormal cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:10:04Z

[Term]
id: MP:0010788
name: stomach hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the stomach, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "gastric hypoplasia" EXACT []
synonym: "hypoplastic stomach" EXACT []
is_a: MP:0002691 ! small stomach
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:11:03Z

[Term]
id: MP:0010789
name: abnormal stomach mesentery morphology
def: "any structural anomaly of the double layer of peritoneum that encloses the stomach and connects it to the abdominal wall" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mesogastrium morphology" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:14:24Z

[Term]
id: MP:0010790
name: abnormal stomach pyloric antrum morphology
def: "any structural anomaly of the area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells" [ISBN:0-683-40008-8]
synonym: "abnormal stomach lesser cul-de-sac morphology" EXACT []
is_a: MP:0010785 ! abnormal stomach pyloric region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:35:02Z

[Term]
id: MP:0010791
name: abnormal pyloric canal morphology
def: "any structural anomaly of the short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010785 ! abnormal stomach pyloric region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-08T11:54:35Z

[Term]
id: MP:0010792
name: abnormal stomach mucosa morphology
alt_id: MP:0005209
def: "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gastric mucosa" EXACT []
synonym: "abnormal gastric mucosa morphology" EXACT []
synonym: "abnormal mucosa of stomach" EXACT []
synonym: "abnormal stomach mucus membrane morphology" EXACT []
xref: MA:0002683
is_a: MP:0010783 ! abnormal stomach wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T09:18:57Z

[Term]
id: MP:0010793
name: abnormal stomach serosa morphology
def: "any structural anomaly of the outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gastric serosa morphology" EXACT []
is_a: MP:0010783 ! abnormal stomach wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T09:22:43Z

[Term]
id: MP:0010794
name: abnormal stomach submucosa morphology
def: "any structural anomaly of the fibrous connective tissue layer beneath the stomach mucosa" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010783 ! abnormal stomach wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T09:22:59Z

[Term]
id: MP:0010795
name: abnormal cardiac gastric gland morphology
def: "any structural anomaly of the gastric glands in the cardiac region of the stomach; cardiac glands are fewer in number than in the fundus and body, and secrete mucin which coats the stomach and protects it" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiac glands of stomach morphology" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology
is_a: MP:0010798 ! abnormal stomach cardiac region morphology
is_a: MP:0014032 ! abnormal mucous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T10:25:08Z

[Term]
id: MP:0010796
name: abnormal intermediate gastric gland morphology
def: "any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that secrete most of the digestive substances secreted by the stomach" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal fundic gland morphology" NARROW []
synonym: "abnormal fundus gastric gland morphology" NARROW []
synonym: "abnormal stomach body gastric gland morphology" NARROW []
is_a: MP:0003892 ! abnormal gastric gland morphology
is_a: MP:0014032 ! abnormal mucous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T10:25:38Z

[Term]
id: MP:0010797
name: abnormal pyloric gastric gland morphology
def: "any structural anomaly of the gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin" [ISBN:0-683-40008-8]
is_a: MP:0003892 ! abnormal gastric gland morphology
is_a: MP:0010785 ! abnormal stomach pyloric region morphology
is_a: MP:0014032 ! abnormal mucous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T10:26:01Z

[Term]
id: MP:0010798
name: abnormal stomach cardiac region morphology
def: "any structural anomaly of the stomach region where the esophagus empties into the stomach" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T10:26:48Z

[Term]
id: MP:0010799
name: stomach mucosa hyperplasia
def: "increase in the number of normal cells in normal arrangement in the stomach mucosa, typically resulting in increased thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic stomach mucosa" EXACT []
is_a: MP:0010792 ! abnormal stomach mucosa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T12:04:40Z

[Term]
id: MP:0010800
name: abnormal submucous nerve plexus morphology
def: "any structural anomaly of the gangliated plexus of unmyelinated nerve fibers that ramify the stomach and intestinal submucosa" [ISBN:0-683-40008-8]
synonym: "abnormal Henle's plexus morphology" EXACT []
synonym: "abnormal Meissner's plexus morphology" EXACT []
synonym: "abnormal Remak plexus morphology" EXACT []
synonym: "abnormal submucosal plexus morphology" EXACT []
is_a: MP:0001044 ! abnormal enteric nervous system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T12:20:10Z

[Term]
id: MP:0010801
name: abnormal myenteric nerve plexus morphology
def: "any structural anomaly of the plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses" [ISBN:0-683-40008-8]
synonym: "abnormal Auerbach plexus morphology" EXACT []
is_a: MP:0001044 ! abnormal enteric nervous system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T12:25:21Z

[Term]
id: MP:0010802
name: abnormal intestinal enteroendocrine cell morphology
def: "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intestinal L cell morphology" NARROW []
synonym: "abnormal intestinal S cell morphology" NARROW []
synonym: "abnormal intestinal secretin cell morphology" NARROW []
is_a: MP:0000511 ! abnormal intestinal mucosa morphology
is_a: MP:0004141 ! abnormal enteroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T12:42:15Z

[Term]
id: MP:0010803
name: abnormal stomach enteroendocrine cell morphology
def: "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal gastric enteroendocrine cell morphology" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology
is_a: MP:0004141 ! abnormal enteroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T12:49:48Z

[Term]
id: MP:0010804
name: abnormal stomach smooth muscle inner oblique layer morphology
def: "any structural anomaly of the innermost layer of the muscularis; it is not present in all sections of the stomach but is clearly seen in the fundus and near the lesser curvature of the corpus; the oblique fibers disappear distally (towards the pyloric antrum); the oblique layer is responsible for creating the motion that churns and physically breaks down the food" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010779 ! abnormal stomach muscularis externa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T01:24:37Z

[Term]
id: MP:0010805
name: abnormal stomach smooth muscle outer longitudinal layer morphology
def: "any structural anomaly of the most superficial layer of the muscularis; it has two sections, a longitudinal layer that is common with the esophagus and ends in the corpus, and a longitudinal layer that originates in the corpus and spreads into the duodenum" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010779 ! abnormal stomach muscularis externa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T01:25:13Z

[Term]
id: MP:0010806
name: abnormal stomach muscularis mucosa morphology
def: "any structural anomaly of the thin layer of smooth muscle in the mucosal layer of the stomach that functions to agitate the surface area stomach mucosa by moving the villi back and forth" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal muscular layer of stomach mucosa" EXACT []
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0010792 ! abnormal stomach mucosa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-09T01:39:38Z

[Term]
id: MP:0010807
name: abnormal stomach position or orientation
def: "the stomach is displaced from the normal left-sided position and/or orientation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000470 ! abnormal stomach morphology
is_a: MP:0003283 ! abnormal digestive organ placement
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-10T09:50:04Z

[Term]
id: MP:0010808
name: right-sided stomach
def: "stomach is present on the right side of the body instead of the left" [https://orcid.org/0000-0003-3691-0324]
synonym: "dextrogastria" EXACT []
is_a: MP:0004133 ! heterotaxia
is_a: MP:0010807 ! abnormal stomach position or orientation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-10T09:50:21Z

[Term]
id: MP:0010809
name: abnormal club cell morphology
def: "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8]
synonym: "abnormal bronchiolar exocrine cell morphology" EXACT []
synonym: "abnormal Clara cell morphology" EXACT []
is_a: MP:0010897 ! abnormal bronchiole epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:04:24Z

[Term]
id: MP:0010810
name: increased type II pneumocyte number
def: "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [https://orcid.org/0000-0002-6490-7723, ISBN:0412046911, PMID:8540632]
synonym: "increased AT2 number" EXACT []
synonym: "increased ATII number" EXACT []
synonym: "increased Cuboidal type II cell number" EXACT []
synonym: "increased granular pneumocyte number" EXACT []
synonym: "increased Great alveolar cell number" EXACT []
synonym: "increased Lung type 2 cell number" EXACT []
synonym: "increased Lung type II cell number" RELATED []
synonym: "increased TII number" EXACT []
synonym: "increased type 2 alveolar epithelial cell number" EXACT []
synonym: "increased type 2 alveolocyte number" EXACT []
synonym: "increased type 2 pneumocyte number" EXACT []
synonym: "increased type II alveolar epithelial cell number" EXACT []
synonym: "increased type II alveolocyte number" EXACT []
synonym: "increased type II cell number" EXACT []
synonym: "increased type II pneumocytes" EXACT []
synonym: "increased type II pneumonocyte number" EXACT []
xref: CL:0002063
xref: FMA:62501
is_a: MP:0002275 ! abnormal type II pneumocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010811
name: decreased type II pneumocyte number
def: "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [https://orcid.org/0000-0002-6490-7723, ISBN:0412046911, PMID:8540632]
synonym: "decreased AT2 number" EXACT []
synonym: "decreased ATII number" EXACT []
synonym: "decreased Cuboidal type II cell number" EXACT []
synonym: "decreased granular pneumocyte number" EXACT []
synonym: "decreased Great alveolar cell number" EXACT []
synonym: "decreased Lung type 2 cell number" EXACT []
synonym: "decreased Lung type II cell number" RELATED []
synonym: "decreased TII number" EXACT []
synonym: "decreased type 2 alveolar epithelial cell number" EXACT []
synonym: "decreased type 2 alveolocyte number" EXACT []
synonym: "decreased type 2 pneumocyte number" EXACT []
synonym: "decreased type II alveolar epithelial cell number" EXACT []
synonym: "decreased type II alveolocyte number" EXACT []
synonym: "decreased type II cell number" EXACT []
synonym: "decreased type II pneumocytes" EXACT []
synonym: "decreased type II pneumonocyte number" EXACT []
synonym: "reduced AT2 number" EXACT []
synonym: "reduced ATII number" EXACT []
synonym: "reduced Cuboidal type II cell number" EXACT []
synonym: "reduced granular pneumocyte number" EXACT []
synonym: "reduced Great alveolar cell number" EXACT []
synonym: "reduced Lung type 2 cell number" EXACT []
synonym: "reduced Lung type II cell number" RELATED []
synonym: "reduced TII number" EXACT []
synonym: "reduced type 2 alveolar epithelial cell number" EXACT []
synonym: "reduced type 2 alveolocyte number" EXACT []
synonym: "reduced type 2 pneumocyte number" EXACT []
synonym: "reduced type II alveolar epithelial cell number" EXACT []
synonym: "reduced type II alveolocyte number" EXACT []
synonym: "reduced type II cell number" EXACT []
synonym: "reduced type II pneumocytes" EXACT []
synonym: "reduced type II pneumonocyte number" EXACT []
xref: CL:0002063
xref: FMA:62501
is_a: MP:0002275 ! abnormal type II pneumocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010812
name: absent type II pneumocytes
def: "absence of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [https://orcid.org/0000-0002-6490-7723, ISBN:0412046911, PMID:8540632]
synonym: "absent AT2" EXACT []
synonym: "absent ATII" EXACT []
synonym: "absent Cuboidal type II cell" EXACT []
synonym: "absent granular pneumocytes" EXACT []
synonym: "absent Great alveolar cells" EXACT []
synonym: "absent Lung type 2 cells" EXACT []
synonym: "absent Lung type II cells" RELATED []
synonym: "absent TII" EXACT []
synonym: "absent type 2 alveolar epithelial cells" EXACT []
synonym: "absent type 2 alveolocytes" EXACT []
synonym: "absent type 2 pneumocyte" EXACT []
synonym: "absent type II alveolar epithelial cells" EXACT []
synonym: "absent type II alveolocytes" EXACT []
synonym: "absent type II cells" EXACT []
synonym: "absent type II pneumonocytes" EXACT []
xref: CL:0002063
xref: FMA:62501
is_a: MP:0010811 ! decreased type II pneumocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010813
name: abnormal alveolar lamellar body morphology
def: "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002275 ! abnormal type II pneumocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010814
name: absent alveolar lamellar bodies
def: "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010813 ! abnormal alveolar lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010815
name: enlarged alveolar lamellar bodies
def: "increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased alveolar lamellar body size" EXACT []
is_a: MP:0010813 ! abnormal alveolar lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:42:20Z

[Term]
id: MP:0010816
name: decreased type I pneumocyte number
def: "reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
synonym: "decreased AT1 number" EXACT []
synonym: "decreased ATI number" EXACT []
synonym: "decreased lung type 1 cell number" EXACT []
synonym: "decreased membranous pneumocyte number" EXACT []
synonym: "decreased Pulmonary alveolar type I cell number" EXACT []
synonym: "decreased small alveolar cell number" EXACT []
synonym: "decreased squamous alveolar cell number" EXACT []
synonym: "decreased squamous alveolar lining cell number" EXACT []
synonym: "decreased type 1 alveolar epithelial cell number" EXACT []
synonym: "decreased Type 1 pneumocyte number" EXACT []
synonym: "decreased type I alveolar epithelial cell number" EXACT []
synonym: "decreased type I cell number" EXACT []
synonym: "decreased type I pneumonocyte number" EXACT []
synonym: "reduced AT1 number" EXACT []
synonym: "reduced ATI number" EXACT []
synonym: "reduced lung type 1 cell number" EXACT []
synonym: "reduced membranous pneumocyte number" EXACT []
synonym: "reduced Pulmonary alveolar type I cell number" EXACT []
synonym: "reduced small alveolar cell number" EXACT []
synonym: "reduced squamous alveolar cell number" EXACT []
synonym: "reduced squamous alveolar lining cell number" EXACT []
synonym: "reduced type 1 alveolar epithelial cell number" EXACT []
synonym: "reduced Type 1 pneumocyte number" EXACT []
synonym: "reduced type I alveolar epithelial cell number" EXACT []
synonym: "reduced type I cell number" EXACT []
synonym: "reduced type I pneumocyte number" EXACT []
synonym: "reduced type I pneumonocyte number" EXACT []
xref: CL:0002062
xref: FMA:62500
is_a: MP:0002274 ! abnormal type I pneumocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:43:57Z

[Term]
id: MP:0010817
name: absent type I pneumocytes
def: "absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]
synonym: "absent AT1" EXACT []
synonym: "absent ATI" EXACT []
synonym: "absent lung type 1 cells" EXACT []
synonym: "absent membranous pneumocytes" EXACT []
synonym: "absent Pulmonary alveolar type I cell" EXACT []
synonym: "absent small alveolar cells" EXACT []
synonym: "absent squamous alveolar cell" EXACT []
synonym: "absent squamous alveolar lining cell" EXACT []
synonym: "absent type 1 alveolar epithelial cells" EXACT []
synonym: "absent Type 1 pneumocyte" EXACT []
synonym: "absent type I alveolar epithelial cells" EXACT []
synonym: "absent type I cells" EXACT []
synonym: "absent type I pneumonocytes" EXACT []
xref: CL:0002062
xref: FMA:62500
is_a: MP:0010816 ! decreased type I pneumocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-11T02:44:08Z

[Term]
id: MP:0010818
name: adhesive atelectasis
def: "alveolar collapse in the presence of patent airways, especially when surfactant is inactivated or absent, and is seen in newborn respiratory distress syndrome, acute radiation pneumonitis, or viral pneumonia" [ISBN:0-683-40008-8]
synonym: "microatelectasis" EXACT []
synonym: "nonobstructive atelectasis" EXACT []
is_a: MP:0001177 ! atelectasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T02:57:41Z

[Term]
id: MP:0010819
name: primary atelectasis
def: "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8]
synonym: "neonatal atelectasis" NARROW []
is_a: MP:0001177 ! atelectasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:03:14Z

[Term]
id: MP:0010820
name: abnormal pleura morphology
def: "any structural anomaly of the serous membrane surrounding the lungs and lining the walls of the pleural cavity" [ISBN:0-683-40008-8]
is_a: MP:0002132 ! abnormal respiratory system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:07:39Z

[Term]
id: MP:0010821
name: abnormal visceral pleura morphology
def: "any structural anomaly of the pleura layer attached to and covering the lungs, and which intercalates into the fissures between the lobes" [ISBN:0-683-40008-8]
synonym: "abnormal inner pleura morphology" EXACT []
synonym: "abnormal pulmonary pleura morphology" RELATED []
is_a: MP:0010820 ! abnormal pleura morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:09:56Z

[Term]
id: MP:0010822
name: pneumothorax
def: "free air or gas is present in the pleural cavity" [ISBN:0-683-40008-8]
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:12:11Z

[Term]
id: MP:0010823
name: abnormal parietal pleura morphology
def: "any structural anomaly of the part of the pleura that lines and is attached to the wall of the thoracic cavity" [ISBN:0-683-40008-8]
synonym: "abnormal outer pleura morphology" EXACT []
is_a: MP:0010820 ! abnormal pleura morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:13:50Z

[Term]
id: MP:0010824
name: absent right lung accessory lobe
def: "absence of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax" [ISBN:0486631850, PMID:2050021]
synonym: "absent right lung cardiac lobe" EXACT []
synonym: "absent right lung infracardiac lobe" EXACT []
synonym: "absent right lung median lobe" EXACT []
synonym: "absent right lung postcaval lobe" EXACT []
is_a: MP:0009571 ! abnormal right lung accessory lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:17:54Z

[Term]
id: MP:0010825
name: abnormal lung saccule morphology
def: "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal alveolar saccule morphology" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:48:35Z

[Term]
id: MP:0010826
name: absent lung saccules
def: "absence of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "absent alveolar saccule" EXACT []
is_a: MP:0010825 ! abnormal lung saccule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:54:20Z

[Term]
id: MP:0010827
name: small lung saccule
def: "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "reduced lung saccule size" EXACT []
synonym: "small alveolar saccule" EXACT []
is_a: MP:0010825 ! abnormal lung saccule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T03:54:34Z

[Term]
id: MP:0010828
name: abnormal bronchioalveolar stem cell morphology
def: "any structural anomaly of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury" [CL:0002638]
synonym: "abnormal BASCs" RELATED []
is_a: MP:0006382 ! abnormal lung epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T04:12:04Z

[Term]
id: MP:0010829
name: increased bronchioalveolar stem cell number
def: "greater numbers of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury" [CL:0002638]
synonym: "increased BASC number" RELATED []
is_a: MP:0010828 ! abnormal bronchioalveolar stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T04:12:33Z

[Term]
id: MP:0010830
name: decreased bronchioalveolar stem cell number
def: "reduced numbers of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury" [CL:0002638]
synonym: "decreased BASC number" EXACT []
synonym: "reduced BASC number" RELATED []
synonym: "reduced bronchioalveolar stem cell number" EXACT []
is_a: MP:0010828 ! abnormal bronchioalveolar stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-14T04:12:48Z

[Term]
id: MP:0010831
name: lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "partial lethal" EXACT []
synonym: "partial lethality" EXACT []
synonym: "reduced viability" EXACT []
is_a: MP:0010769 ! abnormal survival
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-15T02:25:11Z

[Term]
id: MP:0010832
name: lethality during fetal growth through weaning
def: "death anytime between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "lethality during foetal growth through weaning" EXACT []
is_a: MP:0010770 ! preweaning lethality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-15T02:48:40Z

[Term]
id: MP:0010833
name: abnormal memory T cell morphology
alt_id: MP:0006385
def: "any structural anomaly of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
synonym: "abnormal memory T lymphocyte morphology" EXACT []
synonym: "abnormal memory T-cell morphology" EXACT []
synonym: "abnormal memory T-lymphocyte morphology" EXACT []
xref: CL:0000813
is_a: MP:0008037 ! abnormal T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:02:22Z

[Term]
id: MP:0010834
name: abnormal CD4-positive, alpha-beta memory T cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
synonym: "abnormal CD4-positive, alpha-beta memory T lymphocyte morphology" EXACT []
synonym: "abnormal CD4-positive, alpha-beta memory T-cell morphology" EXACT []
synonym: "abnormal CD4-positive, alpha-beta memory T-lymphocyte morphology" EXACT []
synonym: "abnormal T4.Mem.Sp morphology" RELATED []
xref: CL:0000897
is_a: MP:0002432 ! abnormal CD4-positive, alpha beta T cell morphology
is_a: MP:0010833 ! abnormal memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:04:25Z

[Term]
id: MP:0010835
name: increased CD4-positive, alpha-beta memory T cell number
def: "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
subset: IMPC
subset: Sanger_Terms
synonym: "increased CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased T4.Mem.Sp number" RELATED []
xref: CL:0000897
is_a: MP:0008049 ! increased memory T cell number
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0012769 ! abnormal CD4-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:05:16Z

[Term]
id: MP:0010836
name: decreased CD4-positive, alpha-beta memory T cell number
def: "reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased T4.Mem.Sp number" RELATED []
synonym: "reduced CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced T4.Mem.Sp number" RELATED []
xref: CL:0000897
is_a: MP:0008050 ! decreased memory T cell number
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0012769 ! abnormal CD4-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:05:28Z

[Term]
id: MP:0010837
name: abnormal CD8-positive, alpha-beta memory T cell morphology
def: "any structural anomaly of a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
synonym: "abnormal CD8-positive, alpha-beta memory T lymphocyte morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta memory T-cell morphology" EXACT []
synonym: "abnormal CD8-positive, alpha-beta memory T-lymphocyte morphology" EXACT []
synonym: "abnormal T.8Mem.Sp morphology" EXACT []
xref: CL:0000909
is_a: MP:0005010 ! abnormal CD8-positive, alpha beta T cell morphology
is_a: MP:0010833 ! abnormal memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:06:22Z

[Term]
id: MP:0010838
name: increased CD8-positive, alpha-beta memory T cell number
def: "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
subset: IMPC
subset: Sanger_Terms
synonym: "increased CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased T.8Mem.Sp number" EXACT []
xref: CL:0000909
is_a: MP:0008049 ! increased memory T cell number
is_a: MP:0008078 ! increased CD8-positive, alpha-beta T cell number
is_a: MP:0012774 ! abnormal CD8-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:06:51Z

[Term]
id: MP:0010839
name: decreased CD8-positive, alpha-beta memory T cell number
def: "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased T.8Mem.Sp number" EXACT []
synonym: "reduced CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced T.8Mem.Sp number" EXACT []
xref: CL:0000909
is_a: MP:0008050 ! decreased memory T cell number
is_a: MP:0008079 ! decreased CD8-positive, alpha-beta T cell number
is_a: MP:0012774 ! abnormal CD8-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:07:07Z

[Term]
id: MP:0010840
name: abnormal central memory CD4-positive, alpha-beta T cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
synonym: "abnormal central CD4-positive, alpha-beta memory T cell morphology" EXACT []
synonym: "abnormal central CD4-positive, alpha-beta memory T lymphocyte morphology" EXACT []
synonym: "abnormal central CD4-positive, alpha-beta memory T-cell morphology" EXACT []
synonym: "abnormal central CD4-positive, alpha-beta memory T-lymphocyte morphology" EXACT []
synonym: "abnormal central memory CD4-positive, alpha-beta T lymphocyte morphology" EXACT []
synonym: "abnormal central memory CD4-positive, alpha-beta T-cell morphology" EXACT []
synonym: "abnormal central memory CD4-positive, alpha-beta T-lymphocyte morphology" EXACT []
xref: CL:0000904
is_a: MP:0010834 ! abnormal CD4-positive, alpha-beta memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:31:03Z

[Term]
id: MP:0010841
name: increased central memory CD4-positive, alpha-beta T cell number
def: "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
synonym: "increased central CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "increased central CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased central CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased central CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased central memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "increased central memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "increased central memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000904
is_a: MP:0010835 ! increased CD4-positive, alpha-beta memory T cell number
is_a: MP:0010840 ! abnormal central memory CD4-positive, alpha-beta T cell morphology
is_a: MP:0012771 ! abnormal central memory CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:31:23Z

[Term]
id: MP:0010842
name: decreased central memory CD4-positive, alpha-beta T cell number
def: "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
synonym: "decreased central CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "decreased central CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased central CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased central CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased central memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "decreased central memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "decreased central memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
synonym: "reduced central CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "reduced central CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced central CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced central CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced central memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced central memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "reduced central memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000904
is_a: MP:0010836 ! decreased CD4-positive, alpha-beta memory T cell number
is_a: MP:0010840 ! abnormal central memory CD4-positive, alpha-beta T cell morphology
is_a: MP:0012771 ! abnormal central memory CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:31:42Z

[Term]
id: MP:0010843
name: abnormal effector memory CD4-positive, alpha-beta T cell morphology
def: "any structural anomaly of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
synonym: "abnormal effector CD4-positive, alpha-beta memory T cell morphology" EXACT []
synonym: "abnormal effector CD4-positive, alpha-beta memory T lymphocyte morphology" EXACT []
synonym: "abnormal effector CD4-positive, alpha-beta memory T-cell morphology" EXACT []
synonym: "abnormal effector CD4-positive, alpha-beta memory T-lymphocyte morphology" EXACT []
synonym: "abnormal effector memory CD4-positive, alpha-beta T lymphocyte morphology" EXACT []
synonym: "abnormal effector memory CD4-positive, alpha-beta T-cell morphology" EXACT []
synonym: "abnormal effector memory CD4-positive, alpha-beta T-lymphocyte morphology" EXACT []
xref: CL:0000905
is_a: MP:0010834 ! abnormal CD4-positive, alpha-beta memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:32:16Z

[Term]
id: MP:0010844
name: increased effector memory CD4-positive, alpha-beta T cell number
def: "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
synonym: "increased effector CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "increased effector CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased effector CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased effector CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased effector memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "increased effector memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "increased effector memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000905
is_a: MP:0010835 ! increased CD4-positive, alpha-beta memory T cell number
is_a: MP:0010843 ! abnormal effector memory CD4-positive, alpha-beta T cell morphology
is_a: MP:0012770 ! abnormal effector memory CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:32:36Z

[Term]
id: MP:0010845
name: decreased effector memory CD4-positive, alpha-beta T cell number
def: "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
synonym: "decreased effector CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "decreased effector CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased effector CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased effector CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased effector memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "decreased effector memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "decreased effector memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
synonym: "reduced effector CD4-positive, alpha-beta memory T cell number" EXACT []
synonym: "reduced effector CD4-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced effector CD4-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced effector CD4-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced effector memory CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced effector memory CD4-positive, alpha-beta T-cell number" EXACT []
synonym: "reduced effector memory CD4-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000905
is_a: MP:0010836 ! decreased CD4-positive, alpha-beta memory T cell number
is_a: MP:0010843 ! abnormal effector memory CD4-positive, alpha-beta T cell morphology
is_a: MP:0012770 ! abnormal effector memory CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:32:48Z

[Term]
id: MP:0010846
name: abnormal central memory CD8 positive, alpha-beta T cell morphology
def: "any structural anomaly of a CD8-positive, alpha beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
synonym: "abnormal central CD8-positive, alpha-beta memory T cell morphology" EXACT []
synonym: "abnormal central CD8-positive, alpha-beta memory T lymphocyte morphology" EXACT []
synonym: "abnormal central CD8-positive, alpha-beta memory T-cell morphology" EXACT []
synonym: "abnormal central CD8-positive, alpha-beta memory T-lymphocyte morphology" EXACT []
synonym: "abnormal central memory CD8-positive, alpha-beta T lymphocyte morphology" EXACT []
synonym: "abnormal central memory CD8-positive, alpha-beta T-cell morphology" EXACT []
synonym: "abnormal central memory CD8-positive, alpha-beta T-lymphocyte morphology" EXACT []
xref: CL:0000907
is_a: MP:0010837 ! abnormal CD8-positive, alpha-beta memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:34:09Z

[Term]
id: MP:0010847
name: increased central memory CD8 positive, alpha-beta T cell number
def: "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
synonym: "increased central CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "increased central CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased central CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased central CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased central memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "increased central memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "increased central memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000907
is_a: MP:0010838 ! increased CD8-positive, alpha-beta memory T cell number
is_a: MP:0012772 ! abnormal central memory CD8-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:34:31Z

[Term]
id: MP:0010848
name: decreased central memory CD8 positive, alpha-beta T cell number
def: "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
synonym: "decreased central CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "decreased central CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased central CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased central CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased central memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "decreased central memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "decreased central memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
synonym: "reduced central CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "reduced central CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced central CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced central CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced central memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced central memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "reduced central memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000907
is_a: MP:0010839 ! decreased CD8-positive, alpha-beta memory T cell number
is_a: MP:0012772 ! abnormal central memory CD8-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:34:45Z

[Term]
id: MP:0010849
name: abnormal effector memory CD8-positive, alpha-beta T cell number
def: "any structural anomaly of a CD8-positive, alpha beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
synonym: "abnormal effector CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "abnormal effector CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "abnormal effector CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "abnormal effector CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "abnormal effector memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "abnormal effector memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "abnormal effector memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000913
is_a: MP:0008048 ! abnormal memory T cell number
is_a: MP:0012774 ! abnormal CD8-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:35:29Z

[Term]
id: MP:0010850
name: increased effector memory CD8-positive, alpha-beta T cell number
def: "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
synonym: "increased effector CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "increased effector CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "increased effector CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "increased effector CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "increased effector memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "increased effector memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "increased effector memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000913
is_a: MP:0010838 ! increased CD8-positive, alpha-beta memory T cell number
is_a: MP:0010849 ! abnormal effector memory CD8-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:35:47Z

[Term]
id: MP:0010851
name: decreased effector memory CD8-positive, alpha-beta T cell number
def: "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
synonym: "decreased effector CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "decreased effector CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "decreased effector CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "decreased effector CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "decreased effector memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "decreased effector memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "decreased effector memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
synonym: "reduced effector CD8-positive, alpha-beta memory T cell number" EXACT []
synonym: "reduced effector CD8-positive, alpha-beta memory T lymphocyte number" EXACT []
synonym: "reduced effector CD8-positive, alpha-beta memory T-cell number" EXACT []
synonym: "reduced effector CD8-positive, alpha-beta memory T-lymphocyte number" EXACT []
synonym: "reduced effector memory CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced effector memory CD8-positive, alpha-beta T-cell number" EXACT []
synonym: "reduced effector memory CD8-positive, alpha-beta T-lymphocyte number" EXACT []
xref: CL:0000913
is_a: MP:0010839 ! decreased CD8-positive, alpha-beta memory T cell number
is_a: MP:0010849 ! abnormal effector memory CD8-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T10:35:59Z

[Term]
id: MP:0010852
name: absent epidermal lamellar bodies
def: "absence of a membrane-bounded organelle, specialized for the storage and secretion various substances (glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
comment: The name includes epidermal to distinguish it from lung alveolar cell lamellar bodies.
synonym: "absent keratinosomes" EXACT []
synonym: "absent lamellar bodies" EXACT []
synonym: "absent lamellar granules" EXACT []
synonym: "absent membrane-coating granules" RELATED []
synonym: "absent Odland bodies" EXACT []
synonym: "absent skin lamellar bodies" EXACT []
is_a: MP:0009608 ! abnormal epidermal lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-16T12:16:50Z

[Term]
id: MP:0010853
name: abnormal lung position or orientation
def: "the lung is displaced from the normal position and/or has an altered left/right orientation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-17T02:05:46Z

[Term]
id: MP:0010854
name: lung situs inversus
def: "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "pulmonary situs inversus" EXACT []
is_a: MP:0004133 ! heterotaxia
is_a: MP:0010853 ! abnormal lung position or orientation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-17T02:09:11Z

[Term]
id: MP:0010855
name: pulmonary hyperemia
def: "increased amount of blood flow into the lungs" [https://orcid.org/0000-0003-3691-0324]
synonym: "lung hyperaemia" EXACT []
synonym: "lung hyperemia" EXACT []
synonym: "pulmonary hyperaemia" EXACT []
is_a: MP:0002295 ! abnormal pulmonary circulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-17T02:53:31Z

[Term]
id: MP:0010856
name: dilated respiratory conducting tube
def: "expansion or widening of the lumen of one or more of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated conducting airway" EXACT []
synonym: "dilated conducting airways" EXACT []
synonym: "dilated respiratory conducting tubes" EXACT []
synonym: "enlarged conducting air space" EXACT []
synonym: "enlarged conducting air spaces" EXACT []
synonym: "enlarged conducting airway" EXACT []
synonym: "enlarged conducting airways" EXACT []
is_a: MP:0004391 ! abnormal respiratory conducting tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-17T03:08:25Z

[Term]
id: MP:0010857
name: pulmonary necrosis
def: "morphological changes resulting from pathological death of pulmonary tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "lung necrosis" EXACT []
synonym: "necrotic lung" EXACT []
synonym: "necrotic lungs" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-18T11:12:37Z

[Term]
id: MP:0010858
name: pulmonary epithelial necrosis
def: "morphological changes resulting from pathological death of pulmonary epithelial tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic lung epithelium" EXACT []
synonym: "necrotic pulmonary epithelium" EXACT []
is_a: MP:0006382 ! abnormal lung epithelium morphology
is_a: MP:0010857 ! pulmonary necrosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-18T11:22:52Z

[Term]
id: MP:0010859
name: abnormal anterior commissure pars anterior morphology
def: "any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs" [ISBN:0-683-40008-8]
synonym: "abnormal acA tract morphology" EXACT []
synonym: "abnormal aco" EXACT []
synonym: "abnormal anterior commissure olfactory limb" EXACT []
synonym: "abnormal anterior part of anterior commissure" EXACT []
synonym: "abnormal pars anterior commissurae anterioris" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T01:22:11Z

[Term]
id: MP:0010860
name: abnormal anterior commissure pars posterior morphology
def: "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8]
synonym: "abnormal acP tract morphology" EXACT []
synonym: "abnormal act" EXACT []
synonym: "abnormal anterior commissure temporal limb" EXACT []
synonym: "abnormal pars posterior commissurae anterioris" EXACT []
synonym: "abnormal posterior part of anterior commissure" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T01:22:36Z

[Term]
id: MP:0010861
name: increased respiratory mucosa goblet cell number
def: "greater number of the cells of the respiratory epithelial lining that produce and secrete mucins" [https://orcid.org/0000-0002-6490-7723]
synonym: "respiratory mucosa goblet cell hyperplasia" EXACT []
is_a: MP:0002281 ! abnormal respiratory mucosa goblet cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T01:41:05Z

[Term]
id: MP:0010862
name: decreased respiratory mucosa goblet cell number
def: "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002281 ! abnormal respiratory mucosa goblet cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T01:41:30Z

[Term]
id: MP:0010863
name: absent respiratory mucosa goblet cells
def: "absence of the cells of the respiratory epithelial lining that produce and secrete mucins" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010862 ! decreased respiratory mucosa goblet cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T01:41:45Z

[Term]
id: MP:0010864
name: abnormal enamel knot morphology
def: "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [https://orcid.org/0000-0003-3691-0324, PMID:8808404]
is_a: MP:0030519 ! abnormal inner dental epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-22T02:46:53Z

[Term]
id: MP:0010865
name: prenatal growth retardation
def: "slow or limited development during the prenatal period" [https://orcid.org/0000-0003-3691-0324]
synonym: "intrauterine growth restriction" EXACT []
is_a: MP:0004196 ! abnormal prenatal growth/weight/body size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-23T11:03:05Z

[Term]
id: MP:0010866
name: abnormal prenatal body size
def: "anomaly in the average body weight, height and/or length of an organism compared to controls at anytime prior to birth" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004196 ! abnormal prenatal growth/weight/body size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-02-23T11:05:22Z

[Term]
id: MP:0010867
name: abnormal bone trabecula morphology
def: "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000130 ! abnormal trabecular bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:44:39Z

[Term]
id: MP:0010868
name: increased bone trabecula number
def: "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010867 ! abnormal bone trabecula morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:44:39Z

[Term]
id: MP:0010869
name: decreased bone trabecula number
def: "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced bone trabecula number" EXACT []
is_a: MP:0010867 ! abnormal bone trabecula morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:44:39Z

[Term]
id: MP:0010870
name: absent bone trabeculae
def: "absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010867 ! abnormal bone trabecula morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:44:39Z

[Term]
id: MP:0010871
name: abnormal trabecular bone mass
def: "anomaly in the total amount of trabecular bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cancellous bone mass" EXACT []
synonym: "abnormal spongy bone mass" EXACT []
synonym: "abnormal spongy spongiosa mass" EXACT []
synonym: "abnormal spongy substance mass" EXACT []
synonym: "abnormal substantia trabecularis mass" EXACT []
is_a: MP:0000130 ! abnormal trabecular bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:45:30Z

[Term]
id: MP:0010872
name: increased trabecular bone mass
def: "greater total amount of trabecular bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cancellous bone mass" EXACT []
synonym: "increased spongy bone mass" EXACT []
synonym: "increased spongy spongiosa mass" EXACT []
synonym: "increased spongy substance mass" EXACT []
synonym: "increased substantia trabecularis mass" EXACT []
is_a: MP:0005605 ! increased bone mass
is_a: MP:0010871 ! abnormal trabecular bone mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:45:30Z

[Term]
id: MP:0010873
name: decreased trabecular bone mass
def: "reduced total amount of trabecular bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cancellous bone mass" EXACT []
synonym: "decreased spongy bone mass" EXACT []
synonym: "decreased spongy spongiosa mass" EXACT []
synonym: "decreased spongy substance mass" EXACT []
synonym: "decreased substantia trabecularis mass" EXACT []
is_a: MP:0004016 ! decreased bone mass
is_a: MP:0010871 ! abnormal trabecular bone mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:45:30Z

[Term]
id: MP:0010874
name: abnormal bone volume
def: "any anomaly in the amount of space occupied by bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:46:45Z

[Term]
id: MP:0010875
name: increased bone volume
def: "increased amount of space occupied by bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010874 ! abnormal bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:46:45Z

[Term]
id: MP:0010876
name: decreased bone volume
def: "reduced amount of space occupied by bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced bone volume" EXACT []
is_a: MP:0010874 ! abnormal bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:46:45Z

[Term]
id: MP:0010877
name: abnormal trabecular bone volume
def: "any anomaly in the amount of space occupied by trabecular bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cancellous bone volume" EXACT []
synonym: "abnormal spongy bone volume" EXACT []
synonym: "abnormal spongy spongiosa volume" EXACT []
synonym: "abnormal spongy substance volume" EXACT []
synonym: "abnormal substantia trabecularis volume" EXACT []
is_a: MP:0000130 ! abnormal trabecular bone morphology
is_a: MP:0010874 ! abnormal bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:47:23Z

[Term]
id: MP:0010878
name: increased trabecular bone volume
def: "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cancellous bone volume" EXACT []
synonym: "increased spongy bone volume" EXACT []
synonym: "increased spongy spongiosa volume" EXACT []
synonym: "increased spongy substance volume" EXACT []
synonym: "increased substantia trabecularis volume" EXACT []
is_a: MP:0010875 ! increased bone volume
is_a: MP:0010877 ! abnormal trabecular bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:47:23Z

[Term]
id: MP:0010879
name: decreased trabecular bone volume
def: "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cancellous bone volume" EXACT []
synonym: "decreased spongy bone volume" EXACT []
synonym: "decreased spongy spongiosa volume" EXACT []
synonym: "decreased spongy substance volume" EXACT []
synonym: "decreased substantia trabecularis volume" EXACT []
synonym: "reduced cancellous bone volume" EXACT []
synonym: "reduced spongy bone volume" EXACT []
synonym: "reduced spongy spongiosa volume" EXACT []
synonym: "reduced spongy substance volume" EXACT []
synonym: "reduced substantia trabecularis volume" EXACT []
synonym: "reduced trabecular bone volume" EXACT []
is_a: MP:0010876 ! decreased bone volume
is_a: MP:0010877 ! abnormal trabecular bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T03:47:23Z

[Term]
id: MP:0010880
name: small esophagus
def: "reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased esophagus size" EXACT []
synonym: "decreased oesophagus size" EXACT []
synonym: "small oesophagus" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:00:16Z

[Term]
id: MP:0010881
name: esophagus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the esophagus, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "esophageal hypoplasia" EXACT []
synonym: "hypoplastic esophagus" EXACT []
synonym: "hypoplastic oesophagus" EXACT []
synonym: "oesophageal hypoplasia" EXACT []
synonym: "oesophagus hypoplasia" EXACT []
is_a: MP:0010880 ! small esophagus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:00:47Z

[Term]
id: MP:0010882
name: trachea hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the trachea, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic trachea" EXACT []
synonym: "tracheal hypoplasia" EXACT []
is_a: MP:0004549 ! small trachea
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:02:01Z

[Term]
id: MP:0010883
name: trachea stenosis
def: "abnormal narrowing or constriction of the trachea" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow trachea" EXACT []
synonym: "tracheal stenosis" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:03:02Z

[Term]
id: MP:0010884
name: esophagus stenosis
def: "abnormal narrowing or constriction of the esophagus" [https://orcid.org/0000-0002-6490-7723]
synonym: "esophageal stenosis" EXACT []
synonym: "narrow esophagus" EXACT []
synonym: "narrow oesophagus" EXACT []
synonym: "oesophageal stenosis" EXACT []
synonym: "oesophagus stenosis" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:03:58Z

[Term]
id: MP:0010885
name: absent trachea
def: "absence of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002282 ! abnormal trachea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:05:08Z

[Term]
id: MP:0010886
name: absent minor salivary glands
def: "all of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands are absent" [MGI:llw2]
is_a: MP:0003791 ! abnormal minor salivary gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:06:16Z

[Term]
id: MP:0010887
name: pale lung
def: "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:07:19Z

[Term]
id: MP:0010889
name: small alveolar lamellar bodies
def: "decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased alveolar lamellar body size" EXACT []
is_a: MP:0010813 ! abnormal alveolar lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:15:20Z

[Term]
id: MP:0010890
name: decreased alveolar lamellar body number
def: "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010813 ! abnormal alveolar lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:15:20Z

[Term]
id: MP:0010891
name: increased alveolar lamellar body number
def: "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010813 ! abnormal alveolar lamellar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:15:20Z

[Term]
id: MP:0010892
name: increased oligodendrocyte progenitor number
def: "greater number of cells that differentiate into a type of glial cell in the central nervous system" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased oligodendrocyte precursor number" EXACT []
is_a: MP:0014325 ! abnormal oligodendrocyte progenitor morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-02T04:18:41Z

[Term]
id: MP:0010893
name: abnormal posterior commissure morphology
def: "any structural anomaly of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei" [ISBN:0-683-40008-8]
synonym: "abnormal epithalamic commissure morphology" EXACT []
is_a: MP:0002199 ! abnormal brain commissure morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T10:12:41Z

[Term]
id: MP:0010894
name: pulmonary alveolar edema
def: "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [https://orcid.org/0000-0002-6490-7723]
synonym: "pulmonary alveolar oedema" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology
is_a: MP:0003828 ! pulmonary edema
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T12:43:22Z

[Term]
id: MP:0010895
name: increased lung compliance
def: "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788X]
synonym: "increased pulmonary compliance" EXACT []
is_a: MP:0002333 ! abnormal lung compliance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:01:00Z

[Term]
id: MP:0010896
name: decreased lung compliance
def: "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788X]
synonym: "decreased pulmonary compliance" EXACT []
synonym: "reduced lung compliance" EXACT []
is_a: MP:0002333 ! abnormal lung compliance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:01:36Z

[Term]
id: MP:0010897
name: abnormal bronchiole epithelium morphology
def: "any structural anomaly of the epithelial layer of the bronchioles" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002267 ! abnormal bronchiole morphology
is_a: MP:0006382 ! abnormal lung epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:16:28Z

[Term]
id: MP:0010898
name: abnormal pulmonary alveolus epithelium morphology
def: "any structural anomaly of the epithelial layer of the alveoli" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal respiratory alveolus epithelium morphology" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology
is_a: MP:0006382 ! abnormal lung epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:16:56Z

[Term]
id: MP:0010899
name: abnormal pulmonary alveolar system morphology
def: "any structural anomaly of the portion of the lung comprised of the pulmonary acinus and the alveolar parenchyma" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:25:38Z

[Term]
id: MP:0010900
name: abnormal pulmonary interalveolar septum morphology
def: "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal alveolar septum morphology" EXACT []
synonym: "abnormal interalveolar septum morphology" EXACT []
synonym: "abnormal septum interalveolare morphology" EXACT []
is_a: MP:0010911 ! abnormal pulmonary acinus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:26:37Z

[Term]
id: MP:0010901
name: abnormal pulmonary alveolar parenchyma morphology
def: "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [https://orcid.org/0000-0003-3691-0324, ISBN:070202788X]
is_a: MP:0010899 ! abnormal pulmonary alveolar system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:27:30Z

[Term]
id: MP:0010902
name: abnormal pulmonary alveolar sac morphology
def: "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8]
synonym: "abnormal air sac morphology" EXACT []
is_a: MP:0010911 ! abnormal pulmonary acinus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:41:11Z

[Term]
id: MP:0010903
name: abnormal pulmonary alveolus wall morphology
def: "any structural anomaly in the tissue that encloses the alveolar space of the lung" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal pulmonary alveolar wall morphology" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T01:52:28Z

[Term]
id: MP:0010904
name: abnormal alveolar pore morphology
def: "any structural anomaly of the openings in the alveolar septum that permit air flow between adjacent alveoli" [ISBN:0-683-40008-8]
synonym: "abnormal interalveolar pores" EXACT []
synonym: "abnormal pores of Kohn" EXACT []
is_a: MP:0010900 ! abnormal pulmonary interalveolar septum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T02:49:12Z

[Term]
id: MP:0010905
name: absent alveolar pores
def: "absence of the openings in the alveolar septum that permit air flow between adjacent alveoli" [ISBN:0-683-40008-8]
synonym: "absent interalveolar pores" EXACT []
synonym: "absent pores of Kohn" EXACT []
is_a: MP:0010904 ! abnormal alveolar pore morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T02:50:18Z

[Term]
id: MP:0010906
name: abnormal lung bud morphology
def: "any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lung buds" EXACT []
synonym: "abnormal primary lung bud morphology" EXACT []
synonym: "abnormal tracheal bud morphology" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T02:58:37Z

[Term]
id: MP:0010907
name: absent lung buds
def: "absence of the blunt end of the respiratory diverticulum which normally grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the origins of the bronchial tree" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent primary lung buds" EXACT []
synonym: "absent tracheal buds" EXACT []
synonym: "lung bud agenesis" EXACT []
is_a: MP:0010906 ! abnormal lung bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T02:59:58Z

[Term]
id: MP:0010908
name: dilated pulmonary alveolar duct
def: "expansion or widening of the lumen of one or more of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar duct dilation" EXACT []
synonym: "dilated alveolar duct" EXACT []
synonym: "dilated alveolar ducts" EXACT []
synonym: "dilated pulmonary alveolar ducts" EXACT []
synonym: "dilated respiratory alveolar duct" EXACT []
synonym: "dilated respiratory alveolar ducts" EXACT []
synonym: "enlarged alveolar duct" EXACT []
synonym: "enlarged alveolar ducts" EXACT []
synonym: "pulmonary alveolar duct dilation" EXACT []
synonym: "respiratory alveolar duct dilation" EXACT []
is_a: MP:0002271 ! abnormal pulmonary alveolar duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T03:06:00Z

[Term]
id: MP:0010909
name: pulmonary alveolar hemorrhage
def: "bleeding into the small sac-like dilations of the distal airspace of the lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar bleeding" EXACT []
synonym: "alveolar haemorrhage" EXACT []
synonym: "alveolar hemorrhage" EXACT []
synonym: "intra-alveolar haemorrhage" EXACT []
synonym: "intra-alveolar hemorrhage" EXACT []
synonym: "lung alveolar haemorrhage" EXACT []
synonym: "lung alveolar hemorrhage" EXACT []
synonym: "pulmonary alveolar haemorrhage" EXACT []
is_a: MP:0001182 ! lung hemorrhage
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-04T03:08:24Z

[Term]
id: MP:0010910
name: bronchiolar epithelial hyperplasia
def: "increase in the number of normal cells in normal arrangement in the bronchiolar epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324]
synonym: "hyperplastic bronchiolar epithelium" EXACT []
is_a: MP:0010897 ! abnormal bronchiole epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-08T09:42:20Z

[Term]
id: MP:0010911
name: abnormal pulmonary acinus morphology
def: "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8]
synonym: "abnormal primary pulmonary lobule morphology" EXACT []
synonym: "abnormal respiratory lobule morphology" EXACT []
is_a: MP:0010899 ! abnormal pulmonary alveolar system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T12:31:53Z

[Term]
id: MP:0010912
name: herniated liver
def: "protrusion of any portion of the liver from its normal anatomical position" [https://orcid.org/0000-0002-6490-7723]
synonym: "hepatic herniation" EXACT []
synonym: "liver hernia" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T12:56:06Z

[Term]
id: MP:0010913
name: abnormal neuroendocrine cell morphology
def: "any structural anomaly of a neuron that has the specialized function to produce and secrete hormones, contains neruosecretory granules, and that constitutes, in whole or in part, an endocrine organ or system" [CL:0000165, MESH:A.06.688]
synonym: "abnormal neurosecretory cell morphology" EXACT []
synonym: "abnormal paraneurone morphology" EXACT []
xref: CL:0000165
xref: FMA:83810
is_a: MP:0000631 ! abnormal neuroendocrine gland morphology
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:07:49Z

[Term]
id: MP:0010914
name: abnormal solitary pulmonary neuroendocrine cell morphology
def: "any structural anomaly of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bronchiolar Kulchitsky cell" EXACT []
synonym: "abnormal Feyrter cell morphology" EXACT []
synonym: "abnormal Kulschitzky cells" EXACT []
synonym: "abnormal Kultschitzky cell of bronchiole" EXACT []
synonym: "abnormal P cell" BROAD []
synonym: "abnormal PNECs" EXACT []
synonym: "abnormal respiratory enterochromaffin cell" EXACT []
synonym: "abnormal single pulmonary neuroendocrine cell morphology" EXACT []
xref: CL:0002066
xref: FMA:14118
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:46:27Z

[Term]
id: MP:0010915
name: increased solitary pulmonary neuroendocrine cell number
def: "increased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased bronchiolar Kulchitsky cell number" EXACT []
synonym: "increased Feyrter cell number" EXACT []
synonym: "increased Kulschitzky cells" EXACT []
synonym: "increased Kultschitzky cell of bronchiole number" EXACT []
synonym: "increased P cell number" BROAD []
synonym: "increased PNECs" EXACT []
synonym: "increased respiratory enterochromaffin cell number" EXACT []
synonym: "increased single pulmonary neuroendocrine cell number" EXACT []
xref: CL:0002066
xref: FMA:14118
is_a: MP:0010914 ! abnormal solitary pulmonary neuroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:51:46Z

[Term]
id: MP:0010916
name: decreased solitary pulmonary neuroendocrine cell number
def: "decreased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased bronchiolar Kulchitsky cell number" EXACT []
synonym: "decreased Feyrter cell number" EXACT []
synonym: "decreased Kulschitzky cells" EXACT []
synonym: "decreased Kultschitzky cell of bronchiole number" EXACT []
synonym: "decreased P cell number" BROAD []
synonym: "decreased PNECs" EXACT []
synonym: "decreased respiratory enterochromaffin cell number" EXACT []
synonym: "decreased single pulmonary neuroendocrine cell number" EXACT []
synonym: "reduced bronchiolar Kulchitsky cell number" EXACT []
synonym: "reduced Feyrter cell number" EXACT []
synonym: "reduced Kulschitzky cells" EXACT []
synonym: "reduced Kultschitzky cell of bronchiole number" EXACT []
synonym: "reduced P cell number" BROAD []
synonym: "reduced PNECs" EXACT []
synonym: "reduced respiratory enterochromaffin cell number" EXACT []
synonym: "reduced single pulmonary neuroendocrine cell number" EXACT []
xref: CL:0002066
xref: FMA:14118
is_a: MP:0010914 ! abnormal solitary pulmonary neuroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:51:46Z

[Term]
id: MP:0010917
name: absent solitary pulmonary neuroendocrine cells
def: "absence of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent bronchiolar Kulchitsky cell" EXACT []
synonym: "absent Feyrter cell" EXACT []
synonym: "absent Kulschitzky cells" EXACT []
synonym: "absent Kultschitzky cell of bronchiole" EXACT []
synonym: "absent P cell" BROAD []
synonym: "absent PNECs" EXACT []
synonym: "absent respiratory enterochromaffin cell" EXACT []
synonym: "absent single pulmonary neuroendocrine cell" EXACT []
xref: CL:0002066
xref: FMA:14118
is_a: MP:0010916 ! decreased solitary pulmonary neuroendocrine cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:51:46Z

[Term]
id: MP:0010918
name: abnormal pulmonary neuroendocrine body morphology
def: "any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal NEBs" BROAD []
synonym: "abnormal pulmonary neuroendocrine bodies" BROAD []
synonym: "abnormal pulmonary neuroepithelial bodies" BROAD []
is_a: MP:0006382 ! abnormal lung epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:54:36Z

[Term]
id: MP:0010919
name: increased number of pulmonary neuroendocrine bodies
def: "greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased NEBs" EXACT []
synonym: "increased pulmonary neuroepithelial body number" EXACT []
is_a: MP:0010918 ! abnormal pulmonary neuroendocrine body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:58:13Z

[Term]
id: MP:0010920
name: decreased number of pulmonary neuroendocrine bodies
def: "reduction in the number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased NEBs" EXACT []
synonym: "decreased pulmonary neuroepithelial body number" EXACT []
synonym: "reduced NEBs" EXACT []
synonym: "reduced number of pulmonary neuroendocrine bodies" EXACT []
synonym: "reduced pulmonary neuroepithelial body number" EXACT []
is_a: MP:0010918 ! abnormal pulmonary neuroendocrine body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:58:13Z

[Term]
id: MP:0010921
name: absent pulmonary neuroendocrine bodies
def: "absence of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent NEBs" EXACT []
synonym: "absent pulmonary neuroepithelial bodies" EXACT []
is_a: MP:0010918 ! abnormal pulmonary neuroendocrine body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T03:58:13Z

[Term]
id: MP:0010922
name: alveolitis
def: "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar inflammation" EXACT []
synonym: "alveolus inflammation" EXACT []
is_a: MP:0001861 ! lung inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T04:01:31Z

[Term]
id: MP:0010923
name: calcified pulmonary alveolus
def: "pathologic deposition of calcium salts in the pulmonary alveoli" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar calcinosis" EXACT []
synonym: "calcified pulmonary alveoli" EXACT []
synonym: "pulmonary alveolar calcification" BROAD []
synonym: "pulmonary alveolus calcification" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-10T04:03:13Z

[Term]
id: MP:0010924
name: abnormal osteoid morphology
def: "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8]
synonym: "abnormal prebone tissue morphology" EXACT []
is_a: MP:0002113 ! abnormal skeleton development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:16:12Z

[Term]
id: MP:0010925
name: abnormal osteoid volume
def: "any anomaly in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "abnormal prebone tissue volume" EXACT []
is_a: MP:0010924 ! abnormal osteoid morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:38:50Z

[Term]
id: MP:0010926
name: increased osteoid volume
def: "increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "increased prebone tissue volume" EXACT []
is_a: MP:0010925 ! abnormal osteoid volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:39:31Z

[Term]
id: MP:0010927
name: decreased osteoid volume
def: "reduction in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "decreased prebone tissue volume" EXACT []
synonym: "reduced osteoid volume" EXACT []
synonym: "reduced prebone tissue volume" EXACT []
is_a: MP:0010925 ! abnormal osteoid volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:39:31Z

[Term]
id: MP:0010928
name: abnormal osteoid thickness
def: "anomaly in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "abnormal prebone tissue thickness" EXACT []
is_a: MP:0010924 ! abnormal osteoid morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:39:37Z

[Term]
id: MP:0010929
name: increased osteoid thickness
def: "increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "increased prebone tissue thickness" EXACT []
is_a: MP:0010928 ! abnormal osteoid thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:40:07Z

[Term]
id: MP:0010930
name: decreased osteoid thickness
def: "reduction in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8]
synonym: "decreased prebone tissue thickness" EXACT []
synonym: "reduced osteoid thickness" EXACT []
synonym: "reduced prebone tissue thickness" EXACT []
is_a: MP:0010928 ! abnormal osteoid thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T12:40:07Z

[Term]
id: MP:0010931
name: abnormal trabecular bone connectivity density
def: "any anomaly in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523]
synonym: "abnormal trabecular bone interconnectivity index" EXACT []
is_a: MP:0000130 ! abnormal trabecular bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T01:28:48Z

[Term]
id: MP:0010932
name: increased trabecular bone connectivity density
def: "increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523]
synonym: "increased trabecular bone interconnectivity index" EXACT []
is_a: MP:0010931 ! abnormal trabecular bone connectivity density
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T02:05:30Z

[Term]
id: MP:0010933
name: decreased trabecular bone connectivity density
def: "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523]
synonym: "decreased trabecular bone interconnectivity index" EXACT []
synonym: "reduced trabecular bone connectivity density" EXACT []
synonym: "reduced trabecular bone interconnectivity index" EXACT []
is_a: MP:0010931 ! abnormal trabecular bone connectivity density
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-14T02:05:58Z

[Term]
id: MP:0010934
name: increased subcutaneous adipose tissue amount
def: "increase in amount of adipose tissue beneath the skin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0020997 ! abnormal subcutaneous adipose tissue amount
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T01:58:22Z

[Term]
id: MP:0010935
name: increased airway resistance
def: "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002328 ! abnormal airway resistance
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:04:15Z

[Term]
id: MP:0010936
name: decreased airway resistance
def: "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002328 ! abnormal airway resistance
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:04:39Z

[Term]
id: MP:0010937
name: increased total lung capacity
def: "greater volume of air contained in the lungs at the end of maximal inspiration" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002304 ! abnormal total lung capacity
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:08:19Z

[Term]
id: MP:0010938
name: decreased total lung capacity
def: "reduced volume of air contained in the lungs at the end of maximal inspiration" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002304 ! abnormal total lung capacity
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:08:19Z

[Term]
id: MP:0010939
name: abnormal mandibular prominence morphology
def: "any structural anomaly of the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip" [ISBN:0-683-40008-8]
synonym: "abnormal mandibular process morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:30:40Z

[Term]
id: MP:0010940
name: abnormal maxillary prominence morphology
def: "any structural anomaly of the paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw" [ISBN:0-683-40008-8]
synonym: "abnormal embryonic maxillary process morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:31:27Z

[Term]
id: MP:0010941
name: abnormal foramen magnum morphology
def: "any structural anomaly of the large orifice in the occipital bone through which the spinal cord passes to the cranial cavity and becomes continuous with the medulla oblongata" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal great foramen morphology" RELATED []
is_a: MP:0005269 ! abnormal occipital bone morphology
is_a: MP:0030309 ! abnormal posterior cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-03-15T02:57:43Z

[Term]
id: MP:0010942
name: abnormal respiratory epithelium morphology
def: "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0002132 ! abnormal respiratory system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T11:29:45Z

[Term]
id: MP:0010943
name: abnormal bronchus epithelium morphology
def: "any structural anomaly of the epithelial layer of the bronchi" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bronchial epithelium morphology" EXACT []
is_a: MP:0002264 ! abnormal bronchus morphology
is_a: MP:0006382 ! abnormal lung epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T11:31:02Z

[Term]
id: MP:0010944
name: respiratory epithelium hypertrophy
def: "increase in the bulk size of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi; may be due to cell enlargement or excessive production/accumulation of mucus material" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "hypertrophic airway epithelium" EXACT []
is_a: MP:0010942 ! abnormal respiratory epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T11:35:17Z

[Term]
id: MP:0010945
name: lung epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lung epithelium, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic lung epithelium" EXACT []
is_a: MP:0010942 ! abnormal respiratory epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T11:39:12Z

[Term]
id: MP:0010946
name: hyperpnea
def: "breathing that is deeper and more rapid than normal" [ISBN:0-683-40008-8]
synonym: "hyperpnoea" EXACT []
is_a: MP:0001951 ! abnormal breathing pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T02:51:44Z

[Term]
id: MP:0010947
name: abnormal single-strand DNA break repair
def: "anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair" [GO:0000012]
synonym: "abnormal single strand break repair" EXACT []
xref: GO:0000012
is_a: MP:0008058 ! abnormal DNA repair
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T03:52:40Z

[Term]
id: MP:0010948
name: abnormal double-strand DNA break repair
def: "any anomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal double-strand break repair" EXACT []
xref: GO:00006302
is_a: MP:0008058 ! abnormal DNA repair
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-18T03:52:57Z

[Term]
id: MP:0010949
name: decreased club cell number
def: "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased bronchiolar exocrine cell number" EXACT []
synonym: "decreased Clara cell number" EXACT []
synonym: "reduced bronchiolar exocrine cell number" EXACT []
synonym: "reduced club cell number" EXACT []
is_a: MP:0010809 ! abnormal club cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T09:04:19Z

[Term]
id: MP:0010950
name: abnormal lung hysteresivity
def: "anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue" [PMID:2606848]
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T10:12:37Z

[Term]
id: MP:0010951
name: abnormal lipid oxidation
def: "anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0034440]
is_a: MP:0002118 ! abnormal lipid homeostasis
is_a: MP:0005621 ! abnormal cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:45:21Z

[Term]
id: MP:0010952
name: abnormal fatty acid beta-oxidation
def: "anomaly in the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
is_a: MP:0010953 ! abnormal fatty acid oxidation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:45:36Z

[Term]
id: MP:0010953
name: abnormal fatty acid oxidation
def: "anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GO:0019395]
is_a: MP:0010951 ! abnormal lipid oxidation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:46:18Z

[Term]
id: MP:0010954
name: abnormal cellular respiration
def: "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
synonym: "abnormal oxidative metabolic process" EXACT []
synonym: "abnormal oxidative metabolism" EXACT []
xref: GO:0045333
is_a: MP:0005621 ! abnormal cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:49:41Z

[Term]
id: MP:0010955
name: abnormal respiratory electron transport chain
def: "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
xref: GO:0022904
is_a: MP:0006036 ! abnormal mitochondrial physiology
is_a: MP:0010954 ! abnormal cellular respiration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:51:28Z

[Term]
id: MP:0010956
name: abnormal mitochondrial ATP synthesis coupled electron transport
def: "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010955 ! abnormal respiratory electron transport chain
is_a: MP:0010959 ! abnormal oxidative phosphorylation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-23T03:52:57Z

[Term]
id: MP:0010957
name: abnormal aerobic respiration
def: "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
xref: GO:0009060
is_a: MP:0010954 ! abnormal cellular respiration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T11:21:55Z

[Term]
id: MP:0010958
name: abnormal tricarboxylic acid cycle
def: "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
comment: In eukaryotes the tricarboxylic acid is confined to the mitochondria.
synonym: "abnormal citric acid cycle" EXACT []
synonym: "abnormal Krebs cycle" EXACT []
synonym: "abnormal TCA cycle" EXACT []
xref: GO:0006099
is_a: MP:0006036 ! abnormal mitochondrial physiology
is_a: MP:0010957 ! abnormal aerobic respiration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T11:23:08Z

[Term]
id: MP:0010959
name: abnormal oxidative phosphorylation
def: "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
xref: GO:0006119
is_a: MP:0006036 ! abnormal mitochondrial physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T11:40:43Z

[Term]
id: MP:0010960
name: abnormal compact bone mass
def: "anomaly in the total amount of compact bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cortical bone mass" EXACT []
is_a: MP:0003797 ! abnormal compact bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:06:48Z

[Term]
id: MP:0010961
name: increased compact bone mass
def: "greater than normal total amount of compact bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cortical bone mass" EXACT []
is_a: MP:0005605 ! increased bone mass
is_a: MP:0010960 ! abnormal compact bone mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:07:07Z

[Term]
id: MP:0010962
name: decreased compact bone mass
def: "less than normal total amount of compact bone tissue contained in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cortical bone mass" EXACT []
synonym: "reduced compact bone mass" EXACT []
synonym: "reduced cortical bone mass" EXACT []
is_a: MP:0004016 ! decreased bone mass
is_a: MP:0010960 ! abnormal compact bone mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:07:25Z

[Term]
id: MP:0010963
name: abnormal compact bone volume
def: "any anomaly in the amount of space occupied by compact bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cortical bone volume" EXACT []
is_a: MP:0003797 ! abnormal compact bone morphology
is_a: MP:0010874 ! abnormal bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:08:19Z

[Term]
id: MP:0010964
name: increased compact bone volume
def: "greater than normal amount of space occupied by compact bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cortical bone volume" EXACT []
is_a: MP:0010875 ! increased bone volume
is_a: MP:0010963 ! abnormal compact bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:08:19Z

[Term]
id: MP:0010965
name: decreased compact bone volume
def: "less than normal amount of space occupied by compact bone tissue in the skeleton" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cortical bone volume" EXACT []
synonym: "reduced compact bone volume" EXACT []
synonym: "reduced cortical bone volume" EXACT []
is_a: MP:0010876 ! decreased bone volume
is_a: MP:0010963 ! abnormal compact bone volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:08:19Z

[Term]
id: MP:0010966
name: abnormal compact bone area
def: "anomaly in the total amount of cross-sectional area of compact bone tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003797 ! abnormal compact bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:08:46Z

[Term]
id: MP:0010967
name: increased compact bone area
def: "increase in the total amount of cross-sectional area of compact bone tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010966 ! abnormal compact bone area
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:09:17Z

[Term]
id: MP:0010968
name: decreased compact bone area
def: "reduction in the total amount of cross-sectional area of compact bone tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced compact bone area" EXACT []
is_a: MP:0010966 ! abnormal compact bone area
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:09:17Z

[Term]
id: MP:0010969
name: absent compact bone
def: "absence of the outer layers of solid, hard bone that covers spongy bone" [ISBN:0-683-40008-8]
synonym: "absent cortical bone" EXACT []
is_a: MP:0003797 ! abnormal compact bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:09:50Z

[Term]
id: MP:0010970
name: abnormal compact bone lamellar structure
def: "any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003797 ! abnormal compact bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T02:10:13Z

[Term]
id: MP:0010971
name: abnormal periosteum morphology
def: "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8]
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:22:31Z

[Term]
id: MP:0010972
name: absent periosteum
def: "absence of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8]
is_a: MP:0010971 ! abnormal periosteum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:29:23Z

[Term]
id: MP:0010973
name: increased periosteum thickness
def: "increased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8]
synonym: "thick periosteum" EXACT []
is_a: MP:0010971 ! abnormal periosteum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:29:40Z

[Term]
id: MP:0010974
name: decreased periosteum thickness
def: "decreased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8]
synonym: "reduced periosteum thickness" EXACT []
synonym: "thin periosteum" EXACT []
is_a: MP:0010971 ! abnormal periosteum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:30:09Z

[Term]
id: MP:0010975
name: abnormal lung lobe morphology
def: "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [https://orcid.org/0000-0002-6490-7723]
comment: The human right lung is divided into three lobes as opposed to two lobes on the left, while the mouse right lung consists of four lobes as opposed to a single lobe on the left.
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:38:48Z

[Term]
id: MP:0010976
name: small lung lobe
def: "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010975 ! abnormal lung lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:40:20Z

[Term]
id: MP:0010977
name: fused right lung lobes
def: "complete or partial fusion of the right lung lobes, indicative of defective lobar septation during embryonic lung development" [https://orcid.org/0000-0002-6490-7723]
synonym: "fusion of right lung lobes" EXACT []
synonym: "right lung lobes fusion" EXACT []
is_a: MP:0009570 ! abnormal right lung morphology
is_a: MP:0010975 ! abnormal lung lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-24T03:40:20Z

[Term]
id: MP:0010978
name: absent ureteric bud
def: "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
synonym: "absent UB" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T12:43:03Z

[Term]
id: MP:0010979
name: small ureteric bud
def: "reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
synonym: "decreased ureteric bud size" EXACT []
synonym: "reduced ureteric bud size" EXACT []
synonym: "small UB" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T12:43:03Z

[Term]
id: MP:0010980
name: ectopic ureteric bud
def: "ureteric bud(s) are not located in the normal or expected position" [https://orcid.org/0000-0003-3691-0324]
synonym: "ectopic UB" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T12:43:03Z

[Term]
id: MP:0010981
name: abnormal branching involved in ureteric bud morphogenesis
def: "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]
synonym: "abnormal ureteric bud branching" EXACT []
xref: GO:0001658
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:14:06Z

[Term]
id: MP:0010982
name: abnormal ureteric bud elongation
def: "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:18:53Z

[Term]
id: MP:0010983
name: abnormal ureteric bud invasion
def: "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
is_a: MP:0010982 ! abnormal ureteric bud elongation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:19:39Z

[Term]
id: MP:0010984
name: abnormal metanephric mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [https://orcid.org/0000-0003-3691-0324, PMID:19828308]
synonym: "abnormal metanephric blastema morphology" EXACT []
synonym: "abnormal metanephric mesoderm morphology" EXACT []
synonym: "abnormal nephric mesenchyme morphology" EXACT []
is_a: MP:0010985 ! abnormal kidney mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:20:55Z

[Term]
id: MP:0010985
name: abnormal kidney mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing kidney" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0000527 ! abnormal kidney development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:31:46Z

[Term]
id: MP:0010986
name: abnormal mesonephric mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing mesonephros" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010985 ! abnormal kidney mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:32:27Z

[Term]
id: MP:0010987
name: abnormal nephrogenic mesenchyme morphogenesis
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing nephron" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010985 ! abnormal kidney mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T01:32:47Z

[Term]
id: MP:0010988
name: abnormal bronchial cartilage morphology
def: "any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002264 ! abnormal bronchus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:07:07Z

[Term]
id: MP:0010989
name: fused bronchial cartilage rings
def: "fusion of the hyaline cartilaginous structures that support the bronchi" [https://orcid.org/0000-0002-6490-7723]
synonym: "bronchial cartilage ring fusion" EXACT []
is_a: MP:0010988 ! abnormal bronchial cartilage morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:07:49Z

[Term]
id: MP:0010992
name: increased surfactant secretion
alt_id: MP:0010990
def: "greater production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased production of surfactant" EXACT []
is_a: MP:0004780 ! abnormal surfactant secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:13:18Z

[Term]
id: MP:0010993
name: decreased surfactant secretion
alt_id: MP:0010991
def: "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased production of surfactant" EXACT []
synonym: "reduced production of surfactant" EXACT []
synonym: "reduced surfactant secretion" EXACT []
is_a: MP:0004780 ! abnormal surfactant secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:13:34Z

[Term]
id: MP:0010994
name: aerophagia
def: "excessive swallowing of air or gas" [https://orcid.org/0000-0002-6490-7723]
synonym: "aerophagy" EXACT []
synonym: "air swallowing" EXACT []
is_a: MP:0001663 ! abnormal digestive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:16:37Z

[Term]
id: MP:0010995
name: abnormal lung alveolus development
def: "anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]
synonym: "abnormal alveolarization" EXACT []
synonym: "abnormal alveologenesis" EXACT []
synonym: "abnormal alveolus formation" EXACT []
synonym: "abnormal respiratory alveologenesis" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:21:19Z

[Term]
id: MP:0010996
name: increased aorta wall thickness
def: "increased depth of the part of the aorta that encloses the luminal space" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009866 ! abnormal aorta wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:23:28Z

[Term]
id: MP:0010997
name: decreased aorta wall thickness
def: "decreased depth of the part of the aorta that encloses the luminal space" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced aorta wall thickness" EXACT []
is_a: MP:0009866 ! abnormal aorta wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-30T04:23:28Z

[Term]
id: MP:0010998
name: pulmonary alveolar proteinosis
def: "abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar lipoproteinosis" EXACT []
synonym: "alveolar phospholipidosis" EXACT []
synonym: "alveolar proteinosis" EXACT []
synonym: "PAP" EXACT []
synonym: "pulmonary alveolar lipoproteinosis" EXACT []
synonym: "pulmonary alveolar phospholipoproteinosis" EXACT []
is_a: MP:0002270 ! abnormal pulmonary alveolus morphology
is_a: MP:0010999 ! proteinosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T11:49:24Z

[Term]
id: MP:0010999
name: proteinosis
def: "disordered protein formation and distribution, especially manifested by the accumulation of excess or abnormal proteins in tissues" [ISBN:0-683-40008-8]
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T11:52:00Z

[Term]
id: MP:0011000
name: abnormal allogrooming behavior
def: "defects in the standard of behavior in which individuals in a cohort clean or maintain one another's outer body or appearance" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal allogrooming behaviour" EXACT []
synonym: "abnormal allopreening behavior" EXACT []
synonym: "abnormal allopreening behaviour" EXACT []
is_a: MP:0001440 ! abnormal grooming behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T12:59:39Z

[Term]
id: MP:0011001
name: absence of AMPA-mediated synaptic currents
def: "absence of a measured amplitude, current density or response to stimulation of NMDA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002885 ! abnormal AMPA-mediated synaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T01:28:50Z

[Term]
id: MP:0011002
name: enhanced AMPA-mediated synaptic currents
def: "increase in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002885 ! abnormal AMPA-mediated synaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T01:30:14Z

[Term]
id: MP:0011003
name: reduced AMPA-mediated synaptic currents
def: "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002885 ! abnormal AMPA-mediated synaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T01:30:27Z

[Term]
id: MP:0011004
name: abnormal epidermal stem cell morphology
def: "any structural anomaly of a somatic stem cell that is part of the epidermis" [CL:1000428]
synonym: "abnormal stem cell of epidermis" EXACT []
xref: CL:1000428
xref: FMA:70541
is_a: MP:0003941 ! abnormal skin development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T01:57:30Z

[Term]
id: MP:0011005
name: abnormal epidermal stem cell physiology
def: "any functional anomaly of a somatic stem cell that is part of the epidermis" [CL:1000428]
is_a: MP:0005501 ! abnormal skin physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T01:59:49Z

[Term]
id: MP:0011006
name: abnormal epidermal stem cell proliferation
def: "anomaly in the ability of a somatic stem cell population that is part of the epidermis to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0011005 ! abnormal epidermal stem cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T02:01:03Z

[Term]
id: MP:0011007
name: abnormal epidermal stem cell apoptosis
def: "change in the timing or the number of somatic stem cells that are part of the epidermis, undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0011005 ! abnormal epidermal stem cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T02:01:03Z

[Term]
id: MP:0011008
name: abnormal circulating glutamate dehydrogenase level
def: "any anomaly in the concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8]
synonym: "abnormal circulating glutamic acid dehydrogenase level" EXACT []
synonym: "abnormal circulating L-glutamate dehydrogenase level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T03:28:34Z

[Term]
id: MP:0011009
name: increased circulating glutamate dehydrogenase level
def: "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8]
synonym: "increased circulating glutamic acid dehydrogenase level" EXACT []
synonym: "increased circulating L-glutamate dehydrogenase level" EXACT []
is_a: MP:0011008 ! abnormal circulating glutamate dehydrogenase level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T03:34:09Z

[Term]
id: MP:0011010
name: decreased circulating glutamate dehydrogenase level
def: "reduced concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8]
synonym: "decreased circulating glutamic acid dehydrogenase level" EXACT []
synonym: "decreased circulating L-glutamate dehydrogenase level" EXACT []
synonym: "reduced circulating glutamate dehydrogenase level" EXACT []
synonym: "reduced circulating glutamic acid dehydrogenase level" EXACT []
synonym: "reduced circulating L-glutamate dehydrogenase level" EXACT []
is_a: MP:0011008 ! abnormal circulating glutamate dehydrogenase level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-03-31T03:34:39Z

[Term]
id: MP:0011011
name: impaired lung lobe morphogenesis
def: "failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001176 ! abnormal lung development
is_a: MP:0010975 ! abnormal lung lobe morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T12:15:05Z

[Term]
id: MP:0011012
name: bronchiectasis
def: "a chronic inflammatory or degenerative condition marked by permanent dilatation (widening) of one or more bronchi and loss of elasticity of the bronchial walls" [https://orcid.org/0000-0002-6490-7723]
synonym: "bronchiectasia" EXACT []
is_a: MP:0001861 ! lung inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T12:20:51Z

[Term]
id: MP:0011013
name: bronchiolectasis
def: "a chronic inflammatory or degenerative condition marked by permanent dilatation (widening) of one or more bronchioles and loss of elasticity of the bronchiolar walls" [ISBN:0-683-40008-8]
synonym: "bronchiolectasia" EXACT []
is_a: MP:0011012 ! bronchiectasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T12:23:09Z

[Term]
id: MP:0011014
name: decreased core body temperature
def: "reduced degree of heat natural to the internal center of a living being" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced core body temperature" EXACT []
is_a: MP:0005534 ! decreased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:03:06Z

[Term]
id: MP:0011015
name: decreased body surface temperature
def: "reduced degree of heat natural to skin-environment interface of a living being" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced body surface temperature" EXACT []
is_a: MP:0005534 ! decreased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:03:25Z

[Term]
id: MP:0011016
name: increased core body temperature
def: "increased degree of heat natural to the internal center of a living being" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyperpyrexia" NARROW [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005533 ! increased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:15:13Z

[Term]
id: MP:0011017
name: increased body surface temperature
def: "increased degree of heat natural to the skin-environment interface of a living being" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased surface body temperature" EXACT []
is_a: MP:0005533 ! increased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:15:13Z

[Term]
id: MP:0011018
name: pulmonary hyaline membrane formation
def: "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:23:04Z

[Term]
id: MP:0011019
name: abnormal adaptive thermogenesis
def: "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
synonym: "abnormal adaptive thermoregulation" EXACT []
synonym: "abnormal cold adaptation" NARROW []
synonym: "abnormal cold tolerance" NARROW []
synonym: "abnormal shivering response" NARROW []
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T01:33:56Z

[Term]
id: MP:0011020
name: abnormal circadian temperature homeostasis
def: "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
synonym: "abnormal circadian regulation of body temperature" EXACT []
synonym: "abnormal circadian thermoregulation" EXACT []
is_a: MP:0001777 ! abnormal body temperature homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T02:05:49Z

[Term]
id: MP:0011021
name: abnormal circadian regulation of heart rate
def: "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
synonym: "abnormal circadian regulation of heart contraction rate" EXACT []
is_a: MP:0004085 ! abnormal heartbeat
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T02:50:09Z

[Term]
id: MP:0011022
name: abnormal circadian regulation of systemic arterial blood pressure
def: "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
is_a: MP:0010697 ! abnormal systemic arterial blood pressure regulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-06T02:52:11Z

[Term]
id: MP:0011023
name: obsolete absent motile cilia
def: "OBSOLETE. absence of cilia which have a variable arrangement, often with a 9 + 2 microtubular arrangement, of axonemal microtubules, contain molecular motors, and beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues" [GO:0031514]
synonym: "absent motile secondary cilia" EXACT []
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
is_obsolete: true
consider: MP:0004132
consider: MP:0004518
consider: MP:0004526
consider: MP:0004530
consider: MP:0004535
consider: MP:0011054
consider: MP:0011057
consider: MP:0011063
consider: MP:0011645
created_by: mgi
creation_date: 2011-04-07T02:19:30Z

[Term]
id: MP:0011024
name: abnormal branching involved in lung morphogenesis
def: "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T02:56:11Z

[Term]
id: MP:0011025
name: abnormal branching involved in trachea morphogenesis
def: "anomaly in the process in which the two main branches of the trachea is generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
is_a: MP:0013496 ! abnormal trachea development
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011026
name: impaired branching involved in trachea morphogenesis
def: "partial or complete failure of the process in which the two main branches of the trachea is generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011025 ! abnormal branching involved in trachea morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011027
name: abnormal branching involved in bronchus morphogenesis
def: "anomaly in the process in which the branched structure of the bronchus is generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002264 ! abnormal bronchus morphology
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011028
name: impaired branching involved in bronchus morphogenesis
def: "partial or complete failure of the process in which the branched structure of the bronchus is generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011027 ! abnormal branching involved in bronchus morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011029
name: abnormal branching involved in preterminal bronchiole morphogenesis
def: "anomaly in the process in which the branched structure of the preterminal bronchioles are generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011030
name: impaired branching involved in preterminal bronchiole morphogenesis
def: "partial or complete failure of the process in which the branched structure of the preterminal bronchioles are generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011029 ! abnormal branching involved in preterminal bronchiole morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011031
name: abnormal branching involved in terminal bronchiole morphogenesis
def: "anomaly in the process in which the branched structure of the terminal bronchioles are generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002268 ! abnormal terminal bronchiole morphology
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011032
name: impaired branching involved in terminal bronchiole morphogenesis
def: "partial or complete failure of the process in which the branched structure of the terminal bronchioles are generated and organized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011031 ! abnormal branching involved in terminal bronchiole morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011033
name: abnormal branching involved in respiratory bronchiole morphogenesis
def: "anomaly in the process in which the branched structure of the respiratory bronchioles are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004389 ! abnormal respiratory bronchiole morphology
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011034
name: impaired branching involved in respiratory bronchiole morphogenesis
def: "partial or complete failure of the process in which the branched structure of the respiratory bronchioles are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011033 ! abnormal branching involved in respiratory bronchiole morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011035
name: abnormal branching involved in alveolar duct morphogenesis
def: "anomaly in the process in which the branched structure of the alveolar ducts are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002271 ! abnormal pulmonary alveolar duct morphology
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011036
name: impaired branching involved in alveolar duct morphogenesis
def: "partial or complete failure of the process in which the branched structure of the alveolar ducts are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011035 ! abnormal branching involved in alveolar duct morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011037
name: abnormal branching involved in alveolar sac morphogenesis
def: "anomaly in the process in which the terminal alveolar sacs are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010902 ! abnormal pulmonary alveolar sac morphology
is_a: MP:0011024 ! abnormal branching involved in lung morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011038
name: impaired branching involved in alveolar sac morphogenesis
def: "partial or complete failure of the process in which the terminal alveolar sacs are generated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011037 ! abnormal branching involved in alveolar sac morphogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-07T03:03:12Z

[Term]
id: MP:0011039
name: abnormal vestibuloocular dark reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run without light" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal VORD" EXACT []
is_a: MP:0004844 ! abnormal vestibuloocular reflex
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:03:43Z

[Term]
id: MP:0011040
name: abnormal vestibuloocular light reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run with light" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal VORL" EXACT []
is_a: MP:0004844 ! abnormal vestibuloocular reflex
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:03:43Z

[Term]
id: MP:0011041
name: abnormal vertical vestibuloocular reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the vertical axis of the vestibular system" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004844 ! abnormal vestibuloocular reflex
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:03:43Z

[Term]
id: MP:0011042
name: abnormal horizontal vestibuloocular reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the horizontal axis of the vestibular system" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004844 ! abnormal vestibuloocular reflex
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:03:43Z

[Term]
id: MP:0011043
name: abnormal lung elastance
def: "anomaly in the ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lung elasticity" EXACT []
synonym: "abnormal pulmonary elastance" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:13:37Z

[Term]
id: MP:0011044
name: increased lung elastance
def: "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased lung elasticity" EXACT []
synonym: "increased pulmonary elastance" EXACT []
is_a: MP:0011043 ! abnormal lung elastance
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:13:37Z

[Term]
id: MP:0011045
name: decreased lung elastance
def: "reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lung elasticity" EXACT []
synonym: "decreased pulmonary elastance" EXACT []
synonym: "reduced lung elastance" EXACT []
synonym: "reduced lung elasticity" EXACT []
synonym: "reduced pulmonary elastance" EXACT []
is_a: MP:0011043 ! abnormal lung elastance
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:13:37Z

[Term]
id: MP:0011046
name: abnormal lung tissue damping
def: "anomaly in the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:22:33Z

[Term]
id: MP:0011047
name: increased lung tissue damping
def: "increased value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011046 ! abnormal lung tissue damping
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:23:33Z

[Term]
id: MP:0011048
name: decreased lung tissue damping
def: "reduced value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced lung tissue damping" RELATED []
is_a: MP:0011046 ! abnormal lung tissue damping
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:23:33Z

[Term]
id: MP:0011049
name: impaired adaptive thermogenesis
def: "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [https://orcid.org/0000-0003-3691-0324, PMID:16836744]
synonym: "impaired adaptive thermoregulation" EXACT []
synonym: "impaired cold adaptation" NARROW []
synonym: "impaired cold tolerance" NARROW []
synonym: "impaired shivering response" NARROW []
is_a: MP:0011019 ! abnormal adaptive thermogenesis
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-04-08T01:45:22Z

[Term]
id: MP:0011050
name: abnormal respiratory motile cilium morphology
def: "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal airway cilia morphology" EXACT []
synonym: "abnormal airway cilium morphology" EXACT []
synonym: "abnormal respiratory cilia morphology" EXACT []
synonym: "abnormal respiratory cilium morphology" EXACT []
synonym: "abnormal respiratory tract cilia morphology" EXACT []
synonym: "abnormal respiratory tract cilium morphology" EXACT []
is_a: MP:0010942 ! abnormal respiratory epithelium morphology
is_a: MP:0013206 ! abnormal motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T09:50:52Z

[Term]
id: MP:0011051
name: abnormal respiratory motile cilium number
def: "anomaly in the number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal airway cilia number" EXACT []
synonym: "abnormal airway cilium number" EXACT []
synonym: "abnormal respiratory cilia number" EXACT []
synonym: "abnormal respiratory cilium number" EXACT []
synonym: "abnormal respiratory tract cilia number" EXACT []
synonym: "abnormal respiratory tract cilium number" EXACT []
is_a: MP:0011050 ! abnormal respiratory motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:00:43Z

[Term]
id: MP:0011052
name: increased respiratory motile cilia number
def: "greater number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "increased airway cilia number" EXACT []
synonym: "increased airway cilium number" EXACT []
synonym: "increased respiratory cilia number" EXACT []
synonym: "increased respiratory cilium number" EXACT []
synonym: "increased respiratory tract cilia number" EXACT []
synonym: "increased respiratory tract cilium number" EXACT []
is_a: MP:0011051 ! abnormal respiratory motile cilium number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:05:37Z

[Term]
id: MP:0011053
name: decreased respiratory motile cilia number
def: "reduced number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased airway cilia number" EXACT []
synonym: "decreased airway cilium number" EXACT []
synonym: "decreased respiratory cilia number" EXACT []
synonym: "decreased respiratory cilium number" EXACT []
synonym: "decreased respiratory tract cilia number" EXACT []
synonym: "decreased respiratory tract cilium number" EXACT []
is_a: MP:0011051 ! abnormal respiratory motile cilium number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:05:37Z

[Term]
id: MP:0011054
name: absent respiratory motile cilia
def: "absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "absent airway cilia" EXACT []
synonym: "absent airway cilium" EXACT []
synonym: "absent respiratory cilia" EXACT []
synonym: "absent respiratory cilium" EXACT []
synonym: "absent respiratory tract cilia" EXACT []
synonym: "absent respiratory tract cilium" EXACT []
is_a: MP:0011053 ! decreased respiratory motile cilia number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:05:37Z

[Term]
id: MP:0011055
name: abnormal respiratory motile cilium physiology
def: "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal airway cilia physiology" EXACT []
synonym: "abnormal airway cilium physiology" EXACT []
synonym: "abnormal respiratory cilia physiology" EXACT []
synonym: "abnormal respiratory cilium physiology" EXACT []
synonym: "abnormal respiratory tract cilia physiology" EXACT []
synonym: "abnormal respiratory tract cilium physiology" EXACT []
is_a: MP:0013209 ! abnormal motile cilium physiology
is_a: MP:0014200 ! abnormal respiratory epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:05:37Z

[Term]
id: MP:0011056
name: abnormal brain ependyma motile cilium morphology
def: "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain ependyma motile cilia morphology" EXACT []
synonym: "abnormal brain ventricle motile cilium morphology" NARROW []
is_a: MP:0010152 ! abnormal brain ependyma morphology
is_a: MP:0011059 ! abnormal ependyma motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:48:18Z

[Term]
id: MP:0011057
name: absent brain ependyma motile cilia
def: "absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent brain ependyma motile cilium" EXACT []
is_a: MP:0030966 ! decreased brain ependyma motile cilium number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:48:40Z

[Term]
id: MP:0011058
name: abnormal spinal cord motile cilium morphology
def: "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal spinal cord motile cilia morphology" EXACT []
is_a: MP:0010151 ! abnormal spinal cord ependymal layer morphology
is_a: MP:0011059 ! abnormal ependyma motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:49:46Z

[Term]
id: MP:0011059
name: abnormal ependyma motile cilium morphology
def: "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ependyma motile cilia morphology" EXACT []
is_a: MP:0002653 ! abnormal ependyma morphology
is_a: MP:0013206 ! abnormal motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T11:50:19Z

[Term]
id: MP:0011060
name: abnormal kinocilium morphology
def: "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells" [GO:0060091]
synonym: "abnormal kinocilia morphology" EXACT []
is_a: MP:0000045 ! abnormal hair cell morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T12:47:59Z

[Term]
id: MP:0011061
name: abnormal inner hair cell kinocilium morphology
def: "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of inner hair cells" [GO:0060091]
synonym: "abnormal inner hair cell kinocilia morphology" EXACT []
is_a: MP:0004532 ! abnormal inner hair cell stereociliary bundle morphology
is_a: MP:0011060 ! abnormal kinocilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T12:49:07Z

[Term]
id: MP:0011062
name: abnormal outer hair cell kinocilium morphology
def: "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells" [GO:0060091]
synonym: "abnormal outer hair cell kinocilia morphology" EXACT []
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology
is_a: MP:0011060 ! abnormal kinocilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T12:49:07Z

[Term]
id: MP:0011063
name: absent inner hair cell kinocilia
def: "absence of the nonmotile primary cilium that is found at the apical surface of inner hair cells" [GO:0060091]
is_a: MP:0011061 ! abnormal inner hair cell kinocilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T12:55:20Z

[Term]
id: MP:0011064
name: abnormal vestibular hair cell kinocilium morphology
def: "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of vestibular hair cells" [GO:0060091, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal vestibular hair cell kinocilia morphology" EXACT []
is_a: MP:0002623 ! abnormal vestibular hair cell morphology
is_a: MP:0011060 ! abnormal kinocilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T12:59:19Z

[Term]
id: MP:0011065
name: abnormal kidney epithelial cell primary cilium morphology
def: "any structural anomaly of the single non-motile cilium of a kidney epithelial cell that projects into the luminal space of the tubules and ducts where it is thought to act as a flow sensor" [PMID:17995581]
synonym: "abnormal kidney epithelial cell primary cilia morphology" EXACT []
synonym: "abnormal renal epithelial cell primary cilia morphology" EXACT []
synonym: "abnormal renal epithelial cell primary cilium morphology" EXACT []
synonym: "abnormal renal primary cilium morphology" EXACT []
is_a: MP:0004967 ! abnormal kidney epithelium morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T01:42:38Z

[Term]
id: MP:0011066
name: abnormal renal tubule epithelial cell primary cilium morphology
def: "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [https://orcid.org/0000-0003-3691-0324, PMID:17995581]
synonym: "abnormal kidney tubule epithelial cell primary cilium morphology" EXACT []
synonym: "abnormal renal tubule epithelial cell primary cilia morphology" EXACT []
is_a: MP:0009640 ! abnormal renal tubule epithelium morphology
is_a: MP:0011065 ! abnormal kidney epithelial cell primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T02:06:26Z

[Term]
id: MP:0011067
name: abnormal somatostatin level
def: "anomaly of the blood or tissue concentration of a tetradecapeptide capable of inhibiting the release of somatotrophin by the anterior lobe of the pituitary gland and the release of insulin and gastrin from digestive system tissues" [ISBN:0-683-40008-8]
synonym: "abnormal GHIH level" EXACT []
synonym: "abnormal growth hormone-inhibiting hormone level" EXACT []
synonym: "abnormal somatotrophin release-inhibiting factor level" EXACT []
synonym: "abnormal somatotrophin release-inhibiting hormone level" EXACT []
synonym: "abnormal SRIF level" RELATED []
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T03:02:46Z

[Term]
id: MP:0011068
name: abnormal ependyma motile cilium physiology
def: "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ependyma motile cilia physiology" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0013209 ! abnormal motile cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T03:15:16Z

[Term]
id: MP:0011069
name: abnormal brain ependyma motile cilium physiology
def: "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brain ependyma motile cilia physiology" RELATED []
synonym: "abnormal brain ventricle motile cilium physiology" NARROW []
is_a: MP:0011068 ! abnormal ependyma motile cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T03:16:27Z

[Term]
id: MP:0011070
name: abnormal spinal cord motile cilium physiology
def: "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal spinal cord motile cilia physiology" EXACT []
is_a: MP:0011068 ! abnormal ependyma motile cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-14T03:17:05Z

[Term]
id: MP:0011071
name: absent club cells
def: "absence of the rounded, club-shaped, nonciliated cells found between ciliated cells in the bronchiolar epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent bronchiolar exocrine cells" EXACT []
synonym: "absent Clara cells" EXACT []
is_a: MP:0010949 ! decreased club cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T02:00:35Z

[Term]
id: MP:0011072
name: abnormal macrophage cytokine production
def: "any anomaly in the appearance of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in a change to its intracellular or extracellular levels" [GO:0010934]
is_a: MP:0002451 ! abnormal macrophage physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T02:56:24Z

[Term]
id: MP:0011073
name: abnormal macrophage apoptosis
def: "excessive or absent cell death in macrophages" [ISBN:0-683-40008-8]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002451 ! abnormal macrophage physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T02:58:41Z

[Term]
id: MP:0011074
name: abnormal macrophage nitric oxide production
def: "any anomaly in the appearance of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal macrophage NO production" EXACT []
is_a: MP:0002451 ! abnormal macrophage physiology
is_a: MP:0003957 ! abnormal nitric oxide homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:08:25Z

[Term]
id: MP:0011075
name: abnormal macrophage activation involved in immune response
def: "anomaly in the process in which a change in response and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
is_a: MP:0002451 ! abnormal macrophage physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:11:40Z

[Term]
id: MP:0011076
name: increased macrophage nitric oxide production
def: "greater production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased macrophage NO production" EXACT []
is_a: MP:0011074 ! abnormal macrophage nitric oxide production
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:18:03Z

[Term]
id: MP:0011077
name: decreased macrophage nitric oxide production
def: "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased macrophage NO production" EXACT []
synonym: "reduced macrophage nitric oxide production" EXACT []
synonym: "reduced macrophage NO production" EXACT []
is_a: MP:0011074 ! abnormal macrophage nitric oxide production
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:18:03Z

[Term]
id: MP:0011078
name: increased macrophage cytokine production
def: "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011072 ! abnormal macrophage cytokine production
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:20:18Z

[Term]
id: MP:0011079
name: decreased macrophage cytokine production
def: "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an decrease in its intracellular or extracellular levels" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011072 ! abnormal macrophage cytokine production
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:20:37Z

[Term]
id: MP:0011080
name: increased macrophage apoptosis
def: "greater incidence of cell death in macrophages" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0011073 ! abnormal macrophage apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:22:52Z

[Term]
id: MP:0011081
name: decreased macrophage apoptosis
def: "reduced incidence of cell death in macrophages" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced macrophage apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0011073 ! abnormal macrophage apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:22:52Z

[Term]
id: MP:0011082
name: abnormal gastrointestinal motility
def: "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001663 ! abnormal digestive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-15T03:48:24Z

[Term]
id: MP:0011083
name: lethality at weaning, complete penetrance
def: "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete lethality at weaning" EXACT []
is_a: MP:0008569 ! lethality at weaning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:13:15Z

[Term]
id: MP:0011084
name: lethality at weaning, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial lethality at weaning" EXACT []
is_a: MP:0008569 ! lethality at weaning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:13:38Z

[Term]
id: MP:0011085
name: postnatal lethality, complete penetrance
def: "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "complete postnatal lethality" EXACT []
synonym: "juvenile lethality, complete penetrance" EXACT []
is_a: MP:0002082 ! postnatal lethality
is_a: MP:0011111 ! lethality during fetal growth through weaning, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:16:20Z

[Term]
id: MP:0011086
name: postnatal lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "juvenile lethality, incomplete penetrance" EXACT []
synonym: "partial postnatal lethality" EXACT []
is_a: MP:0002082 ! postnatal lethality
is_a: MP:0011112 ! lethality during fetal growth through weaning, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:16:36Z

[Term]
id: MP:0011087
name: neonatal lethality, complete penetrance
def: "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete neonatal lethality" EXACT []
is_a: MP:0002058 ! neonatal lethality
is_a: MP:0011089 ! perinatal lethality, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:39:34Z

[Term]
id: MP:0011088
name: neonatal lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial neonatal lethality" EXACT []
is_a: MP:0002058 ! neonatal lethality
is_a: MP:0011090 ! perinatal lethality, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:39:34Z

[Term]
id: MP:0011089
name: perinatal lethality, complete penetrance
def: "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete perinatal lethality" EXACT []
is_a: MP:0002081 ! perinatal lethality
is_a: MP:0011111 ! lethality during fetal growth through weaning, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:39:34Z

[Term]
id: MP:0011090
name: perinatal lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial perinatal lethality" EXACT []
is_a: MP:0002081 ! perinatal lethality
is_a: MP:0011112 ! lethality during fetal growth through weaning, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T09:39:34Z

[Term]
id: MP:0011091
name: prenatal lethality, complete penetrance
def: "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "complete prenatal lethality" EXACT []
is_a: MP:0002080 ! prenatal lethality
is_a: MP:0011100 ! preweaning lethality, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011092
name: embryonic lethality, complete penetrance
def: "death of all organisms of a given genotype in a population within the embryonic period prior to the completion of organogenesis (Mus: prior to E14)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "complete embryonic lethality" EXACT []
is_a: MP:0008762 ! embryonic lethality
is_a: MP:0031661 ! prenatal lethality prior to heart atrial septation, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011093
name: embryonic lethality at implantation, complete penetrance
def: "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality at implantation" EXACT []
is_a: MP:0008527 ! embryonic lethality at implantation
is_a: MP:0014259 ! embryonic lethality prior to organogenesis, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011094
name: embryonic lethality before implantation, complete penetrance
def: "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality before implantation" EXACT []
is_a: MP:0006204 ! embryonic lethality before implantation
is_a: MP:0014259 ! embryonic lethality prior to organogenesis, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011095
name: embryonic lethality between implantation and placentation, complete penetrance
def: "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality between implantation and placentation" EXACT []
is_a: MP:0009850 ! embryonic lethality between implantation and placentation
is_a: MP:0014259 ! embryonic lethality prior to organogenesis, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011096
name: embryonic lethality between implantation and somite formation, complete penetrance
def: "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality before somite formation" RELATED []
synonym: "complete embryonic lethality between implantation and somite formation" EXACT []
is_a: MP:0006205 ! embryonic lethality between implantation and somite formation
is_a: MP:0011095 ! embryonic lethality between implantation and placentation, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011097
name: embryonic lethality between somite formation and embryo turning, complete penetrance
def: "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality before turning of embryo" RELATED []
synonym: "complete embryonic lethality between somite formation and embryo turning" EXACT []
is_a: MP:0006206 ! embryonic lethality between somite formation and embryo turning
is_a: MP:0011095 ! embryonic lethality between implantation and placentation, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011098
name: embryonic lethality during organogenesis, complete penetrance
def: "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete embryonic lethality during organogenesis" EXACT []
is_a: MP:0006207 ! embryonic lethality during organogenesis
is_a: MP:0011092 ! embryonic lethality, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011099
name: lethality throughout fetal growth and development, complete penetrance
def: "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete lethality throughout fetal growth and development" EXACT []
synonym: "complete lethality throughout foetal growth and development" EXACT []
synonym: "lethality throughout foetal growth and development, complete penetrance" EXACT []
is_a: MP:0006208 ! lethality throughout fetal growth and development
is_a: MP:0011111 ! lethality during fetal growth through weaning, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011100
name: preweaning lethality, complete penetrance
def: "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete preweaning lethality" EXACT []
is_a: MP:0010770 ! preweaning lethality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011101
name: prenatal lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "partial prenatal lethality" EXACT []
is_a: MP:0002080 ! prenatal lethality
is_a: MP:0011110 ! preweaning lethality, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011102
name: embryonic lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to the completion of organogenesis (Mus: prior to E14)" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
synonym: "partial embryonic lethality" EXACT []
is_a: MP:0008762 ! embryonic lethality
is_a: MP:0031660 ! prenatal lethality prior to heart atrial septation, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011103
name: embryonic lethality at implantation, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality at implantation" EXACT []
is_a: MP:0008527 ! embryonic lethality at implantation
is_a: MP:0014260 ! embryonic lethality prior to organogenesis, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011104
name: embryonic lethality before implantation, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality before implantation" EXACT []
is_a: MP:0006204 ! embryonic lethality before implantation
is_a: MP:0014260 ! embryonic lethality prior to organogenesis, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011105
name: embryonic lethality between implantation and placentation, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality between implantation and placentation" EXACT []
is_a: MP:0009850 ! embryonic lethality between implantation and placentation
is_a: MP:0014260 ! embryonic lethality prior to organogenesis, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011106
name: embryonic lethality between implantation and somite formation, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality before somite formation" RELATED []
synonym: "partial embryonic lethality between implantation and somite formation" EXACT []
is_a: MP:0006205 ! embryonic lethality between implantation and somite formation
is_a: MP:0011105 ! embryonic lethality between implantation and placentation, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011107
name: embryonic lethality between somite formation and embryo turning, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality before turning of embryo" RELATED []
synonym: "partial embryonic lethality between somite formation and embryo turning" EXACT []
is_a: MP:0006206 ! embryonic lethality between somite formation and embryo turning
is_a: MP:0011105 ! embryonic lethality between implantation and placentation, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011108
name: embryonic lethality during organogenesis, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial embryonic lethality during organogenesis" EXACT []
is_a: MP:0006207 ! embryonic lethality during organogenesis
is_a: MP:0011102 ! embryonic lethality, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011109
name: lethality throughout fetal growth and development, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [https://orcid.org/0000-0003-3691-0324]
synonym: "lethality throughout foetal growth and development, incomplete penetrance" EXACT []
synonym: "partial lethality throughout fetal growth and development" EXACT []
synonym: "partial lethality throughout foetal growth and development" EXACT []
is_a: MP:0006208 ! lethality throughout fetal growth and development
is_a: MP:0011112 ! lethality during fetal growth through weaning, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011110
name: preweaning lethality, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "partial preweaning lethality" EXACT []
is_a: MP:0010770 ! preweaning lethality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:56:08Z

[Term]
id: MP:0011111
name: lethality during fetal growth through weaning, complete penetrance
def: "death of all organisms of a given genotype in a population between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "complete lethality during fetal growth through weaning" EXACT []
synonym: "complete lethality during foetal growth through weaning" EXACT []
synonym: "lethality during foetal growth through weaning, complete penetrance" EXACT []
is_a: MP:0010832 ! lethality during fetal growth through weaning
is_a: MP:0011100 ! preweaning lethality, complete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:57:54Z

[Term]
id: MP:0011112
name: lethality during fetal growth through weaning, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [https://orcid.org/0000-0003-3691-0324]
synonym: "lethality during foetal growth through weaning, incomplete penetrance" EXACT []
synonym: "partial lethality during fetal growth through weaning" EXACT []
synonym: "partial lethality during foetal growth through weaning" EXACT []
is_a: MP:0010832 ! lethality during fetal growth through weaning
is_a: MP:0011110 ! preweaning lethality, incomplete penetrance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-04-26T03:57:54Z

[Term]
id: MP:0011113
name: abnormal airway basal cell morphology
def: "any structural anomaly of a long-lived multipotent stem cell of the pseudostratified airway epithelium which is restricted to the tracheal epithelium in mice; airway BCs have been shown to be capable of self renewal, give rise to secretory (Clara) cells and ciliated cells, and play important roles both in epithelial homeostasis and in pathological airway remodeling" [https://orcid.org/0000-0002-6490-7723, PMID:20699479]
is_a: MP:0010942 ! abnormal respiratory epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-11T04:13:01Z

[Term]
id: MP:0011114
name: abnormal airway basal cell differentiation
def: "abnormal or arrest of differentiation of the long-lived multipotent stem cell population of the pseudostratified airway epithelium; changes in the lineage choice of BCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders" [https://orcid.org/0000-0002-6490-7723, PMID:17909629]
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0011113 ! abnormal airway basal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-11T04:19:42Z

[Term]
id: MP:0011115
name: airway basal cell hyperplasia
def: "increased number of the long-lived multipotent stem cells of the pseudostratified airway epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased airway basal cell number" EXACT []
is_a: MP:0011113 ! abnormal airway basal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-11T04:19:42Z

[Term]
id: MP:0011116
name: absent Reichert's membrane
def: "absence of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal endoderm; normally required for the maternofetal exchange of nutrients and important for postgastrulation development" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003954 ! abnormal Reichert's membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-11T04:24:38Z

[Term]
id: MP:0011117
name: abnormal susceptibility to weight gain
def: "anomaly in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [https://orcid.org/0000-0003-3691-0324]
comment: These terms should be used when there is some external intervention that is expected to alter the weight of both the experimental and control groups or for alterantions in age-related changes in body weight.
is_a: MP:0001259 ! abnormal body weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: csmith
creation_date: 2011-05-20T11:20:20Z

[Term]
id: MP:0011118
name: abnormal susceptibility to weight loss
def: "anomaly in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001259 ! abnormal body weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T11:21:59Z

[Term]
id: MP:0011119
name: abnormal primordial ovarian follicle number
def: "abnormal numbers of the ovarian follicle that is indiscernible to the naked eye and develops into to primary, secondary, and finally mature vesicular follicles" [UBERON:0003981]
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0009361 ! abnormal primordial ovarian follicle morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:35:03Z

[Term]
id: MP:0011120
name: increased primordial ovarian follicle number
def: "greater than normal numbers of the ovarian follicle that is indiscernible to the naked eye and develops into to primary, secondary, and finally mature vesicular follicles" [UBERON:0003981]
is_a: MP:0011119 ! abnormal primordial ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:35:03Z

[Term]
id: MP:0011121
name: decreased primordial ovarian follicle number
def: "fewer than normal numbers of the ovarian follicle that is indiscernible to the naked eye and develops into to primary, secondary, and finally mature vesicular follicles" [UBERON:0003981]
synonym: "reduced primordial ovarian follicle number" EXACT []
is_a: MP:0011119 ! abnormal primordial ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:35:03Z

[Term]
id: MP:0011122
name: absent primordial ovarian follicles
def: "absence of the ovarian follicle that is indiscernible to the naked eye and develops into to primary, secondary, and finally mature vesicular follicles" [UBERON:0003981]
is_a: MP:0011121 ! decreased primordial ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:35:03Z

[Term]
id: MP:0011123
name: abnormal primary ovarian follicle number
def: "abnormal numbers of the ovarian follicle that is characterized by the presence of a single layer of granulosa cells" [UBERON:0000035]
synonym: "abnormal folliculus ovaricus primarius number" EXACT []
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0009362 ! abnormal primary ovarian follicle morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:37:49Z

[Term]
id: MP:0011124
name: increased primary ovarian follicle number
def: "greater than normal numbers of the ovarian follicle that is characterized by the presence of a single layer of granulosa cells" [UBERON:0000035]
synonym: "increased folliculus ovaricus primarius number" EXACT []
is_a: MP:0011123 ! abnormal primary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:37:49Z

[Term]
id: MP:0011125
name: decreased primary ovarian follicle number
def: "fewer than normal numbers of the ovarian follicle that is characterized by the presence of a single layer of granulosa cells" [UBERON:0000035]
synonym: "decreased folliculus ovaricus primarius number" EXACT []
synonym: "reduced folliculus ovaricus primarius number" EXACT []
synonym: "reduced primary ovarian follicle number" EXACT []
is_a: MP:0011123 ! abnormal primary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:37:49Z

[Term]
id: MP:0011126
name: absent primary ovarian follicles
def: "absence of the ovarian follicle that is characterized by the presence of a single layer of granulosa cells" [UBERON:0000035]
synonym: "absent folliculus ovaricus primarius" EXACT []
is_a: MP:0011125 ! decreased primary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
created_by: csmith
creation_date: 2011-05-20T11:37:49Z

[Term]
id: MP:0011127
name: abnormal tertiary ovarian follicle number
def: "abnormal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [https://orcid.org/0000-0003-3691-0324, UBERON:0000037]
synonym: "abnormal antral follicle number" EXACT []
synonym: "abnormal folliculus ovaricus tertiarius number" EXACT []
synonym: "abnormal folliculus ovaricus vesiculosus number" EXACT []
synonym: "abnormal Graafian follicle number" EXACT []
synonym: "abnormal vesicular follicle of ovary number" EXACT []
synonym: "abnormal vesicular ovarian follicle number" EXACT []
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0009363 ! abnormal tertiary ovarian follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T11:39:46Z

[Term]
id: MP:0011128
name: increased tertiary ovarian follicle number
def: "greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [https://orcid.org/0000-0003-3691-0324, UBERON:0000037]
synonym: "increased antral follicle number" EXACT []
synonym: "increased folliculus ovaricus tertiarius number" EXACT []
synonym: "increased folliculus ovaricus vesiculosus number" EXACT []
synonym: "increased Graafian follicle number" EXACT []
synonym: "increased vesicular follicle of ovary number" EXACT []
synonym: "increased vesicular ovarian follicle number" EXACT []
is_a: MP:0011127 ! abnormal tertiary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T11:39:46Z

[Term]
id: MP:0011129
name: decreased tertiary ovarian follicle number
def: "fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [https://orcid.org/0000-0003-3691-0324, UBERON:0000037]
synonym: "decreased antral follicle number" EXACT []
synonym: "decreased folliculus ovaricus tertiarius number" EXACT []
synonym: "decreased folliculus ovaricus vesiculosus number" EXACT []
synonym: "decreased Graafian follicle number" EXACT []
synonym: "decreased vesicular follicle of ovary number" EXACT []
synonym: "decreased vesicular ovarian follicle number" EXACT []
synonym: "reduced antral follicle number" EXACT []
synonym: "reduced folliculus ovaricus tertiarius number" EXACT []
synonym: "reduced folliculus ovaricus vesiculosus number" EXACT []
synonym: "reduced Graafian follicle number" EXACT []
synonym: "reduced vesicular follicle of ovary number" EXACT []
synonym: "reduced vesicular ovarian follicle number" EXACT []
is_a: MP:0011127 ! abnormal tertiary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T11:39:46Z

[Term]
id: MP:0011130
name: absent tertiary ovarian follicles
def: "absence of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [https://orcid.org/0000-0003-3691-0324, UBERON:0000037]
synonym: "absent antral follicles" EXACT []
synonym: "absent folliculus ovaricus tertiarius" EXACT []
synonym: "absent folliculus ovaricus vesiculosus" EXACT []
synonym: "absent Graafian follicles" EXACT []
synonym: "absent vesicular follicles of ovary" EXACT []
synonym: "absent vesicular ovarian follicles" EXACT []
is_a: MP:0011129 ! decreased tertiary ovarian follicle number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T11:39:46Z

[Term]
id: MP:0011131
name: abnormal lung endothelial cell physiology
def: "any functional anomaly of the squamous cells forming the lining of the pulmonary vasculature" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung microvascular endothelial cell physiology" EXACT []
synonym: "abnormal pulmonary endothelial cell physiology" EXACT []
is_a: MP:0014200 ! abnormal respiratory epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:03:47Z

[Term]
id: MP:0011132
name: abnormal lung endothelial cell migration
def: "anomaly in the movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung microvascular endothelial cell migration" EXACT []
synonym: "abnormal pulmonary endothelial cell migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0011131 ! abnormal lung endothelial cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011133
name: increased lung endothelial cell migration
def: "increased or faster movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lung microvascular endothelial cell migration" EXACT []
synonym: "increased pulmonary endothelial cell migration" EXACT []
is_a: MP:0011132 ! abnormal lung endothelial cell migration
is_a: MP:0011804 ! increased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011134
name: decreased lung endothelial cell migration
def: "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lung microvascular endothelial cell migration" EXACT []
synonym: "decreased pulmonary endothelial cell migration" EXACT []
synonym: "reduced lung microvascular endothelial cell migration" EXACT []
synonym: "reduced pulmonary endothelial cell migration" EXACT []
is_a: MP:0011132 ! abnormal lung endothelial cell migration
is_a: MP:0011805 ! decreased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011135
name: abnormal lung endothelial cell adhesion
def: "altered ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung microvascular endothelial cell adhesion" EXACT []
synonym: "abnormal pulmonary endothelial cell adhesion" EXACT []
is_a: MP:0011131 ! abnormal lung endothelial cell physiology
is_a: MP:0020317 ! abnormal vascular endothelial cell adhesion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011136
name: increased lung endothelial cell adhesion
def: "increased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lung microvascular endothelial cell adhesion" EXACT []
synonym: "increased pulmonary endothelial cell adhesion" EXACT []
is_a: MP:0011135 ! abnormal lung endothelial cell adhesion
is_a: MP:0020318 ! increased vascular endothelial cell adhesion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011137
name: decreased lung endothelial cell adhesion
def: "decreased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lung microvascular endothelial cell adhesion" EXACT []
synonym: "decreased pulmonary endothelial cell adhesion" EXACT []
synonym: "reduced lung microvascular endothelial cell adhesion" EXACT []
synonym: "reduced pulmonary endothelial cell adhesion" EXACT []
is_a: MP:0011135 ! abnormal lung endothelial cell adhesion
is_a: MP:0020319 ! decreased vascular endothelial cell adhesion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011138
name: abnormal lung endothelial cell proliferation
def: "altered ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung microvascular endothelial cell proliferation" EXACT []
synonym: "abnormal pulmonary endothelial cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0011131 ! abnormal lung endothelial cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011139
name: increased lung endothelial cell proliferation
def: "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased lung microvascular endothelial cell proliferation" EXACT []
synonym: "increased pulmonary endothelial cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011138 ! abnormal lung endothelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011140
name: decreased lung endothelial cell proliferation
def: "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased lung microvascular endothelial cell proliferation" EXACT []
synonym: "decreased pulmonary endothelial cell proliferation" EXACT []
synonym: "reduced lung microvascular endothelial cell proliferation" EXACT []
synonym: "reduced pulmonary endothelial cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011138 ! abnormal lung endothelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011141
name: increased lung endothelial cell apoptosis
def: "acceleration in the timing or in the number of endothelial cells in the pulmonary vasculature undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung microvascular endothelial cell apoptosis" EXACT []
synonym: "abnormal pulmonary endothelial cell apoptosis" EXACT []
is_a: MP:0011131 ! abnormal lung endothelial cell physiology
is_a: MP:0030002 ! increased lung apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T02:06:38Z

[Term]
id: MP:0011142
name: abnormal lung-associated mesenchyme development
def: "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [https://orcid.org/0000-0002-6490-7723, PMID:18533146, PMID:20048339]
synonym: "abnormal lung mesenchyme development" EXACT []
synonym: "abnormal pulmonary mesenchyme development" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011143
name: thick lung-associated mesenchyme
def: "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [https://orcid.org/0000-0002-6490-7723]
synonym: "expanded lung mesenchyme" EXACT []
synonym: "thick pulmonary mesenchyme" EXACT []
synonym: "thickened lung mesenchyme" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011144
name: thin lung-associated mesenchyme
def: "decreased thickness of the mesenchymal cell layer in the developing lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced lung mesenchyme" EXACT []
synonym: "thin pulmonary mesenchyme" EXACT []
synonym: "thinned lung mesenchyme" EXACT []
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011145
name: abnormal mesenchymal cell differentiation involved in lung development
def: "abnormal or arrest of differentiation of the mesenchymal cell population in the developing lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lung mesenchymal cell differentiation" EXACT []
synonym: "abnormal pulmonary mesenchymal cell differentiation" EXACT []
is_a: MP:0001176 ! abnormal lung development
is_a: MP:0005076 ! abnormal cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011146
name: abnormal mesenchymal cell proliferation involved in lung development
def: "anomaly in the ability of the differentiating lung mesenchymal cell population to undergo expansion by cell division in the developing lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lung mesenchymal cell proliferation" EXACT []
synonym: "abnormal pulmonary mesenchymal cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0001176 ! abnormal lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011147
name: increased mesenchymal cell proliferation involved in lung development
def: "increase in the expansion rate of a lung mesenchymal cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased lung mesenchymal cell proliferation" EXACT []
synonym: "increased pulmonary mesenchymal cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011146 ! abnormal mesenchymal cell proliferation involved in lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011148
name: decreased mesenchymal cell proliferation involved in lung development
def: "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lung mesenchymal cell proliferation" EXACT []
synonym: "decreased pulmonary mesenchymal cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011146 ! abnormal mesenchymal cell proliferation involved in lung development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-20T04:11:17Z

[Term]
id: MP:0011149
name: abnormal hippocampus stratum lacunosum morphology
def: "any structural anomaly in the thin stratum in the hippocampus that is immediately deep to the molecular layer, and is superficial to the stratum radiatum" [http://purl.obolibrary.org/obo/UBERON_0005370]
is_a: MP:0000813 ! abnormal hippocampus layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011150
name: abnormal hippocampus stratum oriens morphology
def: "any structural anomaly of the layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3" [NIFSTD:birnlex_4113, UBERON_0005371]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000813 ! abnormal hippocampus layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011151
name: abnormal hippocampus stratum radiatum morphology
def: "any structural anomaly of the layer located immediately above the pyramidal cell layer in CA2 and CA1 and superficial to the stratum lucidum in CA3. Suprapyramidal region in which CA3 to CA3 associational connections and CA3 to CA1 Schaffer collateral connections are located" [NIFSTD:birnlex_1298, UBERON_0005372]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0000813 ! abnormal hippocampus layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011152
name: thick hippocampus molecular cell layer
def: "increase in the width of the cytoarchitectural region of the hippocampus consisting of a composite of the two outermost layers of the hippocampus, the Stratum lacunosum-moleculare and the Stratum radiatum" [UBERON_0005368]
synonym: "thick stratum moleculare" EXACT []
is_a: MP:0008286 ! abnormal hippocampus molecular cell layer
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011153
name: thick hippocampus stratum oriens
def: "increase in the width of the layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3" [NIFSTD:birnlex_4113, UBERON_0005371]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011150 ! abnormal hippocampus stratum oriens morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011154
name: thick hippocampus stratum radiatum
def: "increase in the width of the layer located immediately above the pyramidal cell layer in CA2 and CA1 and superficial to the stratum lucidum in CA3" [NIFSTD:birnlex_1298, UBERON_0005372]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011151 ! abnormal hippocampus stratum radiatum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:29:51Z

[Term]
id: MP:0011155
name: absent hippocampus stratum oriens
def: "absence of the layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3" [NIFSTD:birnlex_4113, UBERON_0005371]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011150 ! abnormal hippocampus stratum oriens morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:30:16Z

[Term]
id: MP:0011156
name: abnormal hypodermis fat layer morphology
def: "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal hypodermal fat layer morphology" EXACT []
synonym: "abnormal panniculus adiposus morphology" EXACT []
synonym: "abnormal subcutaneous fat layer morphology" EXACT []
is_a: MP:0002970 ! abnormal white adipose tissue morphology
is_a: MP:0003705 ! abnormal hypodermis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:52:15Z

[Term]
id: MP:0011157
name: abnormal hypodermis muscle layer morphology
def: "any structural anomaly of the skeletal muscle layer in the superficial fascia" [ISBN:0-683-40008-8]
synonym: "abnormal hypodermal muscle layer morphology" EXACT []
synonym: "abnormal panniculus carnosus morphology" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0003705 ! abnormal hypodermis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:53:01Z

[Term]
id: MP:0011158
name: absent hypodermis muscle layer
def: "absence of the skeletal muscle layer in the superficial fascia" [ISBN:0-683-40008-8]
synonym: "absent hypodermal muscle layer" EXACT []
synonym: "absent panniculus carnosus" RELATED []
is_a: MP:0011157 ! abnormal hypodermis muscle layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-23T03:53:40Z

[Term]
id: MP:0011159
name: abnormal epidermal-dermal junction morphology
def: "any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" [PMID:1097542]
synonym: "abnormal dermal-epidermal junction morphology" EXACT []
synonym: "abnormal dermo-epidermal junction morphology" EXACT []
synonym: "abnormal EDJ morphology" EXACT []
xref: FMA:70963
is_a: MP:0002060 ! abnormal skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-25T03:52:09Z

[Term]
id: MP:0011160
name: dermal-epidermal separation
def: "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011159 ! abnormal epidermal-dermal junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-25T04:10:23Z

[Term]
id: MP:0011161
name: increased hypodermis neovascularization
def: "new or excessive vessel proliferation in the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypodermal neovascularization" EXACT []
is_a: MP:0003705 ! abnormal hypodermis morphology
is_a: MP:0003711 ! pathological neovascularization
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T12:12:39Z

[Term]
id: MP:0011162
name: abnormal wet-to-dry lung weight ratio
def: "any deviation from the standard ratio, calculated by dividing the wet lung weight (measured immediately after lung excision) to the oven-dried lung weight, compared to control samples; may be used as an index of extravascular fluid accumulation (pulmonary edema) and/or tissue damage after lung injury" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005629 ! abnormal lung weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T12:57:37Z

[Term]
id: MP:0011163
name: increased wet-to-dry lung weight ratio
def: "an increase in the ratio of wet lung weight (measured immediately after lung excision) to oven-dried lung weight relative to control samples; may reflect an inability to expel remaining amniotic fluid out of the lungs during or shortly after birth, or increased fluid accumulation (pulmonary edema) and/or tissue damage after lung injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased wet lung weight" EXACT []
is_a: MP:0011162 ! abnormal wet-to-dry lung weight ratio
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T12:58:04Z

[Term]
id: MP:0011164
name: panniculitis
def: "inflammation of the subcutaneous adipose tissue" [ISBN:0-683-40008-8]
synonym: "hypodermal fat layer inflammation" EXACT []
synonym: "panniculus adiposus inflammation" EXACT []
synonym: "subcutaneous adipose tissue inflammation" EXACT []
is_a: MP:0010680 ! abnormal skin adnexa physiology
is_a: MP:0020386 ! adipose tissue inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T01:25:38Z

[Term]
id: MP:0011165
name: abnormal tooth root development
def: "aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal dental root development" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0030493 ! abnormal tooth root morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T03:04:20Z

[Term]
id: MP:0011166
name: absent molar root
def: "absence of the part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030494 ! abnormal molar root morphology
is_a: MP:0030495 ! absent tooth root
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-05-26T03:04:51Z

[Term]
id: MP:0011167
name: abnormal adipose tissue development
def: "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [https://orcid.org/0000-0003-3691-0324, MESH:A10.165.114]
synonym: "abnormal adipogenesis" RELATED []
is_a: MP:0000003 ! abnormal adipose tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-07T03:18:55Z

[Term]
id: MP:0011168
name: abnormal fat cell differentiation
def: "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal adipocyte differentiation" EXACT []
synonym: "abnormal adipogenesis" RELATED []
synonym: "abnormal lipocyte differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0009115 ! abnormal fat cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-07T03:18:55Z

[Term]
id: MP:0011169
name: abnormal white fat cell differentation
def: "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [https://orcid.org/0000-0003-3691-0324, MESH:A11.329.114.500]
synonym: "abnormal white adipocyte differentiation" EXACT []
synonym: "abnormal white lipocyte differentiation" EXACT []
is_a: MP:0009117 ! abnormal white fat cell morphology
is_a: MP:0011168 ! abnormal fat cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-07T03:18:55Z

[Term]
id: MP:0011170
name: abnormal brown fat cell differentiation
def: "abnormal or arrest of differentiation of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals" [CL:0000449, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal brown adipocyte differentiation" EXACT []
synonym: "abnormal brown lipocyte differentiation" EXACT []
is_a: MP:0009116 ! abnormal brown fat cell morphology
is_a: MP:0011168 ! abnormal fat cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-07T03:18:55Z

[Term]
id: MP:0011171
name: increased number of Heinz bodies
def: "presence of intracellular inclusions usually attached to the red blood cell membrane, resulting from oxidative injury to and precipitation of hemoglobin in red blood cells" [http://www.dorlands.com/]
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-08T01:56:22Z

[Term]
id: MP:0011172
name: abnormal otic pit morphology
def: "any structural anomaly of the pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles" [ISBN:0-683-40008-8]
synonym: "abnormal auditory pit morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
is_a: MP:0003938 ! abnormal ear development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-13T10:53:23Z

[Term]
id: MP:0011173
name: abnormal otic placode morphology
def: "any structural anomaly of two paired thickened areas of ectoderm close to the hindbrain from which the vestibular system and the auditory system develops; the otic placode invaginates into the mesenchyme adjacent to the rhombencephalon to form the otic pit" [PMID:9507049]
synonym: "abnormal auditory placode morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
is_a: MP:0003938 ! abnormal ear development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-13T10:53:50Z

[Term]
id: MP:0011174
name: lipodystrophy
def: "abnormal or degenerative conditions of the body's adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000003 ! abnormal adipose tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-14T10:40:49Z

[Term]
id: MP:0011175
name: platyspondylia
def: "flatness of the bodies of the vertebrae; one or many vertebrae may be affected" [ISBN:0-683-40008-8]
synonym: "flat vertebral bodies" EXACT []
synonym: "flattened vertebrae" EXACT []
synonym: "flattened vertebral bodies" EXACT []
synonym: "platyspondylisis" EXACT []
synonym: "platyspondyly" EXACT []
is_a: MP:0000141 ! abnormal vertebral body morphology
is_a: MP:0021136 ! abnormal vertebrae shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T11:42:26Z

[Term]
id: MP:0011176
name: abnormal erythroblast morphology
def: "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
comment: In human, these cells are normally found exclusively in the bone marrow. In other species such as rodents, they may be found in liver and/or spleen.
synonym: "abnormal normoblast morphology" RELATED []
is_a: MP:0002416 ! abnormal proerythroblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T12:36:38Z

[Term]
id: MP:0011177
name: abnormal erythroblast number
def: "altered number of the nucleated precursor of erythrocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal normoblast number" RELATED []
is_a: MP:0011176 ! abnormal erythroblast morphology
is_a: MP:0013661 ! abnormal myeloid cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T12:37:30Z

[Term]
id: MP:0011178
name: increased erythroblast number
def: "greater number of the nucleated precursor of erythrocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased normoblast number" RELATED []
is_a: MP:0011177 ! abnormal erythroblast number
is_a: MP:0013663 ! increased myeloid cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T12:37:30Z

[Term]
id: MP:0011179
name: decreased erythroblast number
def: "reduced number of the nucleated precursor of erythrocytes" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased normoblast number" RELATED []
synonym: "reduced erythroblast number" EXACT []
synonym: "reduced normoblast number" RELATED []
is_a: MP:0011177 ! abnormal erythroblast number
is_a: MP:0013662 ! decreased myeloid cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T12:37:30Z

[Term]
id: MP:0011180
name: abnormal hematopoietic cell number
def: "any anomaly in the expected number of cells of the hematopoietic lineage" [CL:0000988, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal haematopoietic cell number" EXACT []
is_a: MP:0013656 ! abnormal hematopoietic cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T01:20:15Z

[Term]
id: MP:0011181
name: increased hematopoietic cell number
def: "greater than expected number of cells of the hematopoietic lineage" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased haematopoietic cell number" EXACT []
is_a: MP:0011180 ! abnormal hematopoietic cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T01:20:15Z

[Term]
id: MP:0011182
name: decreased hematopoietic cell number
def: "fewer than expected number of cells of the hematopoietic lineage" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased haematopoietic cell number" EXACT []
is_a: MP:0011180 ! abnormal hematopoietic cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T01:20:15Z

[Term]
id: MP:0011183
name: abnormal primitive endoderm morphology
def: "any structural anomaly of the transient thin monolayer of cuboidal cells that comprise the lower layer of the bilaminar embryonic disk; the hypoblast cells contribute to several extraembryonic structures, but do not contribute to the embryo" [http://discovery.lifemapsc.com/in-vivo-development/hypoblast/hypoblast]
comment: In rodents, the hypoblast cells form the parietal endoderm, parietal and visceral yolk sac as well as extraembryonic membranes, such as the extraembryonic endoderm, the yolk sac and the stalk that links it to the endodermal digestive tube. In human embryos, hypoblast cells migrate and line the blastocoelic cavity of the blastocyst, forming the primary yolk sac and Heuser's membrane. Although both the murine parietal yolk sac and the human primary yolk sac are transient structures, they are not developmental equivalents. A second wave of hypoblast cells migrates to form the definitive yolk sac which displaces the primary yolk sac and is equivalent to the murine visceral yolk sac. The primary yolk sac breaks up into small vesicles that can persist at the mural (abembryonic) pole.
synonym: "abnormal hypoblast morphology" RELATED []
synonym: "abnormal PE morphology" EXACT []
synonym: "abnormal PrE morphology" EXACT []
synonym: "abnormal primary endoderm morphology" EXACT []
is_a: MP:0012103 ! abnormal bilaminar embryonic disk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T02:15:10Z

[Term]
id: MP:0011184
name: absent embryonic epiblast
def: "absence of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion" [http://discovery.lifemapsc.com/in-vivo-development/epiblast/epiblast, PMID:21123814]
comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
synonym: "absent ectoblast" EXACT []
synonym: "absent embryonic ectoderm" EXACT []
synonym: "absent EPI" EXACT []
synonym: "absent primary ectoderm" EXACT []
synonym: "absent primitive ectoderm" EXACT []
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T02:23:11Z

[Term]
id: MP:0011185
name: absent primitive endoderm
def: "absence of the transient thin monolayer of cuboidal cells that comprise the lower layer of the bilaminar embryonic disk; the hypoblast cells contribute to several extraembryonic structures, but do not contribute to the embryo" [http://discovery.lifemapsc.com/in-vivo-development/hypoblast/hypoblast]
synonym: "absent hypoblast" EXACT []
synonym: "absent PE" EXACT []
synonym: "absent PrE" EXACT []
synonym: "absent primary endoderm" EXACT []
is_a: MP:0011183 ! abnormal primitive endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T02:36:57Z

[Term]
id: MP:0011186
name: abnormal visceral endoderm morphology
def: "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
synonym: "abnormal VE morphology" EXACT []
is_a: MP:0005380 ! embryo phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T02:39:29Z

[Term]
id: MP:0011187
name: abnormal parietal endoderm morphology
def: "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
synonym: "abnormal distal endoderm morphology" EXACT []
synonym: "abnormal PaE morphology" EXACT []
synonym: "abnormal ParE morphology" EXACT []
is_a: MP:0011203 ! abnormal parietal yolk sac morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-20T02:39:48Z

[Term]
id: MP:0011188
name: increased erythrocyte protoporphyrin level
def: "an accumulation of the intermediates of heme biosynthesis in red blood cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002447 ! abnormal erythrocyte morphology
is_a: MP:0004147 ! increased porphyrin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-21T03:15:34Z

[Term]
id: MP:0011189
name: small embryonic epiblast
def: "reduced size of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion" [http://discovery.lifemapsc.com/in-vivo-development/epiblast/epiblast, PMID:21123814]
comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
synonym: "reduced epiblast size" EXACT []
synonym: "small ectoblast" EXACT []
synonym: "small embryonic ectoderm" EXACT []
synonym: "small EPI" EXACT []
synonym: "small primary ectoderm" EXACT []
synonym: "small primitive ectoderm" EXACT []
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T01:26:36Z

[Term]
id: MP:0011190
name: thick embryonic epiblast
def: "increased thickness of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion" [http://discovery.lifemapsc.com/in-vivo-development/epiblast/epiblast, PMID:21123814]
comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
synonym: "thick ectoblast" EXACT []
synonym: "thick embryonic ectoderm" EXACT []
synonym: "thick EPI" EXACT []
synonym: "thick primary ectoderm" EXACT []
synonym: "thick primitive ectoderm" EXACT []
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T01:26:36Z

[Term]
id: MP:0011191
name: increased embryonic epiblast cell apoptosis
def: "increase in the number of embryonic epiblast cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T01:26:36Z

[Term]
id: MP:0011192
name: decreased embryonic epiblast cell proliferation
def: "reduction in the expansion rate of the embryonic epiblast cells by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced epiblast cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T01:26:36Z

[Term]
id: MP:0011193
name: embryonic epiblast cell degeneration
def: "a retrogressive impairment of function or destruction of the cells comprising the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion" [http://discovery.lifemapsc.com/in-vivo-development/epiblast/epiblast, PMID:21123814]
comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.
is_a: MP:0003886 ! abnormal embryonic epiblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T01:26:36Z

[Term]
id: MP:0011194
name: abnormal hair follicle physiology
def: "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [https://orcid.org/0000-0003-0431-8641, MESH:A10.272.497.500]
is_a: MP:0010680 ! abnormal skin adnexa physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T03:41:46Z

[Term]
id: MP:0011195
name: increased hair follicle apoptosis
def: "greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [https://orcid.org/0000-0003-0431-8641]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0011194 ! abnormal hair follicle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T03:43:17Z

[Term]
id: MP:0011196
name: decreased hair follicle apoptosis
def: "reduced from expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [https://orcid.org/0000-0003-0431-8641]
synonym: "reduced hair follicle apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0011194 ! abnormal hair follicle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-22T03:43:34Z

[Term]
id: MP:0011197
name: abnormal proamniotic cavity morphology
def: "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
synonym: "abnormal epiblast cavity morphology" EXACT []
synonym: "abnormal preamniotic cavity morphology" EXACT []
synonym: "abnormal pro-amniotic cavity morphology" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:54:24Z

[Term]
id: MP:0011198
name: absent proamniotic cavity
def: "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
synonym: "absent epiblast cavity" EXACT []
synonym: "absent preamniotic cavity" EXACT []
is_a: MP:0011197 ! abnormal proamniotic cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:56:00Z

[Term]
id: MP:0011199
name: abnormal amniotic cavity morphology
def: "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:57:08Z

[Term]
id: MP:0011200
name: abnormal extraembryonic coelom morphology
def: "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN-10:1405118660, ISBN:0-12-402035-6]
comment: Note that there is a great deal of confusion in the literature regarding the term exocoelomic cavity. It is frequently and erroneously used as a synonym for primary yolk sac cavity.
synonym: "abnormal chorion cavity morphology" EXACT []
synonym: "abnormal chorionic cavity morphology" EXACT []
synonym: "abnormal exocoelom morphology" EXACT []
synonym: "abnormal exocoelomic cavity morphology" EXACT []
synonym: "abnormal extraembryonic celom morphology" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:59:48Z

[Term]
id: MP:0011201
name: abnormal visceral yolk sac cavity morphology
def: "any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm)" [ISBN:0-12-402035-6, PMID:21123814]
synonym: "abnormal yolk sac cavity" BROAD []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:59:48Z

[Term]
id: MP:0011202
name: abnormal ectoplacental cavity morphology
def: "any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
synonym: "abnormal epamniotic cavity" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-23T01:59:48Z

[Term]
id: MP:0011203
name: abnormal parietal yolk sac morphology
def: "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert's membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
synonym: "abnormal primary yolk sac morphology" EXACT []
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T03:01:00Z

[Term]
id: MP:0011204
name: abnormal visceral yolk sac blood island morphology
def: "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
is_a: MP:0020516 ! abnormal visceral yolk sac mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T03:11:04Z

[Term]
id: MP:0011205
name: excessive folding of visceral yolk sac
def: "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [https://orcid.org/0000-0003-3691-0324, PMID:17881493]
synonym: "folded visceral yolk sac" EXACT []
synonym: "ruffled visceral yolk sac" EXACT []
synonym: "visceral yolk sac ruffling" EXACT []
synonym: "wrinkled visceral yolk sac" EXACT []
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T03:39:13Z

[Term]
id: MP:0011206
name: absent visceral yolk sac
def: "absence of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [ISBN10:9780123364258, PMID:21123814]
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T03:40:33Z

[Term]
id: MP:0011207
name: absent ectoplacental cavity
def: "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
synonym: "absent epamniotic cavity" EXACT []
is_a: MP:0011202 ! abnormal ectoplacental cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T04:02:46Z

[Term]
id: MP:0011208
name: small proamniotic cavity
def: "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
synonym: "small epiblast cavity" EXACT []
synonym: "small preamniotic cavity" EXACT []
synonym: "small pro-amniotic cavity" EXACT []
is_a: MP:0011197 ! abnormal proamniotic cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T04:03:35Z

[Term]
id: MP:0011209
name: absent extraembryonic coelom
def: "absence of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN10:1405118660, ISBN:0-12-402035-6]
synonym: "absent chorion cavity" EXACT []
synonym: "absent chorionic cavity" EXACT []
synonym: "absent exocoelom" EXACT []
synonym: "absent exocoelomic cavity" EXACT []
is_a: MP:0011200 ! abnormal extraembryonic coelom morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-24T04:06:28Z

[Term]
id: MP:0011210
name: abnormal temporomandibular joint morphology
def: "any structural anomaly of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [ISBN:0-683-40008-8]
synonym: "abnormal mandibular joint morphology" EXACT []
synonym: "abnormal temporo-mandibular joint morphology" EXACT []
synonym: "abnormal temporomandibular articulation morphology" EXACT []
synonym: "abnormal TMJ morphology" EXACT []
xref: FMA:54832
xref: MA:0002899
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-30T02:50:39Z

[Term]
id: MP:0011211
name: abnormal common peroneal nerve morphology
def: "any structural anomaly of a nerve arising at the terminal division of the sciatic nerve at the popliteal fossa and extending to the neck of the fibula, ultimately innervating the Peroneus muscles" [ISBN:0-683-40008-8]
synonym: "abnormal common fibular nerve morphology" EXACT []
synonym: "abnormal external popliteal nerve morphology" EXACT []
synonym: "abnormal lateral popliteal nerve morphology" EXACT []
xref: FMA:19039
xref: MA:0001169
is_a: MP:0002752 ! abnormal somatic nervous system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-30T03:09:04Z

[Term]
id: MP:0011212
name: absent common peroneal nerve
def: "absence of the nerve arising at the terminal division of the sciatic nerve at the popliteal fossa and extending to the neck of the fibula, ultimately innervating the Peroneus muscles" [ISBN:0-683-40008-8]
synonym: "absent common fibular nerve" EXACT []
synonym: "absent external popliteal nerve" EXACT []
synonym: "absent lateral popliteal nerve" EXACT []
is_a: MP:0011211 ! abnormal common peroneal nerve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-06-30T03:25:50Z

[Term]
id: MP:0011213
name: abnormal brain copper level
def: "an anomaly in the amount of copper present in brain tissue" [MGI:llw2]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0003952 ! abnormal copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011214
name: increased brain copper level
def: "a greater accumulation of copper in the brain tissue compared to controls" [MGI:llw2]
is_a: MP:0011213 ! abnormal brain copper level
is_a: MP:0014539 ! increased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011215
name: decreased brain copper level
def: "a reduced amount of copper in the brain tissue compared to controls" [MGI:llw2]
synonym: "reduced brain copper level" EXACT []
is_a: MP:0011213 ! abnormal brain copper level
is_a: MP:0014540 ! decreased copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011216
name: abnormal brainstem copper level
def: "an anomaly in the amount of copper present in brainstem tissue" [MGI:llw2]
is_a: MP:0005277 ! abnormal brainstem morphology
is_a: MP:0011213 ! abnormal brain copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011217
name: increased brainstem copper level
def: "a greater accumulation of copper in the brainstem tissue compared to controls" [MGI:llw2]
is_a: MP:0011214 ! increased brain copper level
is_a: MP:0011216 ! abnormal brainstem copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011218
name: decreased brainstem copper level
def: "a reduced amount of copper in the brainstem tissue compared to controls" [MGI:llw2]
synonym: "reduced brainstem copper level" EXACT []
is_a: MP:0011215 ! decreased brain copper level
is_a: MP:0011216 ! abnormal brainstem copper level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-12T02:49:21Z

[Term]
id: MP:0011219
name: abnormal intestinal calcium absorption
def: "any anomaly in the ability of the body to take up calcium into the blood by absorption from the small intestine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001670 ! abnormal intestinal mineral absorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-14T03:30:43Z

[Term]
id: MP:0011220
name: increased intestinal calcium absorption
def: "augmented ability of the body to take up calcium into the blood by absorption from the small intestine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011219 ! abnormal intestinal calcium absorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-14T03:31:33Z

[Term]
id: MP:0011221
name: decreased intestinal calcium absorption
def: "reduced ability of the body to take up calcium into the blood by absorption from the small intestine" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced intestinal calcium absorption" EXACT []
is_a: MP:0011219 ! abnormal intestinal calcium absorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-14T03:31:33Z

[Term]
id: MP:0011222
name: abnormal lymph node medullary sinus morphology
def: "any structural anomaly of the channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels" [ISBN:0-683-40008-8]
synonym: "abnormal lymph node medullary sinusoids morphology" EXACT []
is_a: MP:0002348 ! abnormal lymph node medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T09:52:45Z

[Term]
id: MP:0011223
name: dilated lymph node medullary sinus
def: "the luminal space of one or more lymph node medullary sinuses is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated lymph node medullary sinuses" EXACT []
synonym: "dilated lymph node medullary sinusoids" EXACT []
synonym: "lymph node medullary sinus dilation" EXACT []
is_a: MP:0011222 ! abnormal lymph node medullary sinus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T09:54:12Z

[Term]
id: MP:0011224
name: abnormal lymph node medullary cord morphology
def: "any structural anomaly of the dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node" [ISBN:0-683-40008-8]
synonym: "abnormal lymph cords morphology" EXACT []
is_a: MP:0002348 ! abnormal lymph node medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T09:54:32Z

[Term]
id: MP:0011225
name: lymph node medullary cord hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lymph node medullary cord, typically resulting in increased size" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperplastic lymph node medullary cords" EXACT []
is_a: MP:0011224 ! abnormal lymph node medullary cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T09:54:39Z

[Term]
id: MP:0011226
name: abnormal thiamin level
def: "any anomaly in the concentration of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver" [GO:0006772]
synonym: "abnormal thiamine level" EXACT []
synonym: "abnormal vitamin B1 level" EXACT []
is_a: MP:0005400 ! abnormal vitamin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T01:53:25Z

[Term]
id: MP:0011227
name: abnormal vitamin B12 level
def: "any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom" [GO:0009236]
synonym: "abnormal cobalamin level" EXACT []
is_a: MP:0005400 ! abnormal vitamin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011228
name: abnormal vitamin D level
def: "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
synonym: "abnormal calciferol level" NARROW []
synonym: "abnormal calciol level" NARROW []
synonym: "abnormal cholecalciferol level" NARROW []
synonym: "abnormal ergocalciferol level" NARROW []
synonym: "abnormal vitamin D2 level" NARROW []
synonym: "abnormal vitamin D3 level" NARROW []
is_a: MP:0005401 ! abnormal fat-soluble vitamin level
is_a: MP:0012224 ! abnormal sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011229
name: abnormal vitamin C level
def: "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
synonym: "abnormal ascorbate level" EXACT []
synonym: "abnormal ascorbic acid level" EXACT []
synonym: "abnormal L-ascorbic acid level" EXACT []
is_a: MP:0005400 ! abnormal vitamin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011230
name: abnormal folic acid level
def: "any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia" [MESH:D03.438.733.631.400]
synonym: "abnormal folate level" NARROW []
synonym: "abnormal folvite level" NARROW []
synonym: "abnormal pteroylglutamic acid level" NARROW []
synonym: "abnormal vitamin B9 level" EXACT []
synonym: "abnormal vitamin M level" EXACT []
is_a: MP:0005400 ! abnormal vitamin level
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011231
name: abnormal vitamin E level
def: "any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant" [GO:0010189]
synonym: "abnormal alpha-tocopherol level" NARROW []
synonym: "abnormal tocopherol level" NARROW []
is_a: MP:0005401 ! abnormal fat-soluble vitamin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011232
name: abnormal vitamin A level
def: "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
synonym: "abnormal retinal level" NARROW []
synonym: "abnormal retinaldehyde level" NARROW []
synonym: "abnormal retinoic acid level" NARROW []
synonym: "abnormal retinol level" NARROW []
is_a: MP:0005401 ! abnormal fat-soluble vitamin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T02:02:26Z

[Term]
id: MP:0011233
name: abnormal vitamin A metabolism
def: "altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
synonym: "abnormal retinal metabolism" NARROW []
synonym: "abnormal retinaldehyde metabolism" NARROW []
synonym: "abnormal retinoic acid metabolism" NARROW []
synonym: "abnormal retinol metabolism" NARROW []
is_a: MP:0013244 ! abnormal vitamin metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T03:06:19Z

[Term]
id: MP:0011234
name: abnormal retinol level
def: "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
synonym: "abnormal vitamin A1 level" EXACT []
is_a: MP:0011232 ! abnormal vitamin A level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-21T03:12:45Z

[Term]
id: MP:0011235
name: abnormal blood oxygen capacity
def: "the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood is not as expected" [ISBN:0-683-40008-8]
synonym: "abnormal blood oxygen affinity" EXACT []
synonym: "abnormal haemoglobin affinity for oxygen" NARROW []
synonym: "abnormal haemoglobin dissociation curve" RELATED []
synonym: "abnormal hemoglobin affinity for oxygen" NARROW []
synonym: "abnormal hemoglobin dissociation curve" RELATED []
synonym: "abnormal oxygen dissociation curve" RELATED []
is_a: MP:0009642 ! abnormal blood homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T11:36:45Z

[Term]
id: MP:0011236
name: increased blood oxygen capacity
def: "an increase in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]
synonym: "increased blood oxygen affinity" EXACT []
is_a: MP:0011235 ! abnormal blood oxygen capacity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T11:47:30Z

[Term]
id: MP:0011237
name: decreased blood oxygen capacity
def: "a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]
synonym: "decreased blood oxygen affinity" EXACT []
is_a: MP:0011235 ! abnormal blood oxygen capacity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T11:47:30Z

[Term]
id: MP:0011238
name: abnormal inner ear development
def: "atypical initial production, differentiation, migration or maturation of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:llw2]
is_a: MP:0000026 ! abnormal inner ear morphology
is_a: MP:0003938 ! abnormal ear development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T12:39:11Z

[Term]
id: MP:0011239
name: abnormal skin coloration
def: "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
subset: IMPC_Prenatal
synonym: "abnormal skin colouration" EXACT []
is_a: MP:0002060 ! abnormal skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T01:21:38Z

[Term]
id: MP:0011240
name: abnormal fetal derived definitive erythrocyte morphology
def: "any structural anomaly of a fetal liver derived enucleated erythrocyte, which matures in macrophage islands within the liver, enucleates, and then enters the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "abnormal foetal derived definitive erythrocyte morphology" EXACT []
synonym: "abnormal liver derived definitive erythrocyte morphology" RELATED []
xref: CL:0002357
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T02:46:43Z

[Term]
id: MP:0011241
name: abnormal fetal derived definitive erythrocyte cell number
def: "anomaly in the number of a fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "abnormal foetal derived definitive erythrocyte cell number" EXACT []
synonym: "abnormal liver derived definitive erythrocyte cell number" RELATED []
xref: CL:0002357
is_a: MP:0001586 ! abnormal erythrocyte cell number
is_a: MP:0011240 ! abnormal fetal derived definitive erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T02:59:33Z

[Term]
id: MP:0011242
name: increased fetal derived definitive erythrocyte cell number
def: "increased number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "increased foetal derived definitive erythrocyte cell number" EXACT []
synonym: "increased liver derived definitive erythrocyte cell number" RELATED []
xref: CL:0002357
is_a: MP:0003131 ! increased erythrocyte cell number
is_a: MP:0011241 ! abnormal fetal derived definitive erythrocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:02:09Z

[Term]
id: MP:0011243
name: decreased fetal derived definitive erythrocyte cell number
def: "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "decreased foetal derived definitive erythrocyte cell number" EXACT []
synonym: "decreased liver derived definitive erythrocyte cell number" RELATED []
synonym: "reduced fetal derived definitive erythrocyte cell number" EXACT []
synonym: "reduced foetal derived definitive erythrocyte cell number" EXACT []
synonym: "reduced liver derived definitive erythrocyte cell number" RELATED []
xref: CL:0002357
is_a: MP:0002875 ! decreased erythrocyte cell number
is_a: MP:0011241 ! abnormal fetal derived definitive erythrocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:02:09Z

[Term]
id: MP:0011244
name: absent fetal derived definitive erythrocytes
def: "absence of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "absent foetal derived definitive erythrocytes" EXACT []
xref: CL:0002357
is_a: MP:0000215 ! absent erythrocytes
is_a: MP:0011243 ! decreased fetal derived definitive erythrocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:02:09Z

[Term]
id: MP:0011245
name: abnormal fetal derived definitive erythrocyte physiology
def: "any functional anomaly of a fetal liver derived enucleated erythrocyte, which matures in macrophage islands within the liver, enucleates, and then enters the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
synonym: "abnormal foetal derived definitive erythrocyte physiology" EXACT []
synonym: "abnormal liver derived definitive erythrocyte physiology" RELATED []
xref: CL:0002357
is_a: MP:0003656 ! abnormal erythrocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:21:28Z

[Term]
id: MP:0011246
name: abnormal fetal liver hematopoietic progenitor cell morphology
def: "any structural anomaly of a hematopoietic stem cell that resides in the fetal liver" [CL:0002353]
comment: In mice, this cell type is first observed at E10.5.
synonym: "abnormal fetal liver haematopoietic progenitor cell morphology" EXACT []
synonym: "abnormal fetal liver hematopoietic stem cell morphology" EXACT []
synonym: "abnormal foetal liver haematopoietic progenitor cell morphology" EXACT []
synonym: "abnormal foetal liver haematopoietic stem cell morphology" EXACT []
xref: CL:0002353
is_a: MP:0004808 ! abnormal hematopoietic stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:23:26Z

[Term]
id: MP:0011247
name: abnormal yolk sac hematopoietic stem cell morphology
def: "any structural anomaly of a hematopoietic stem found in the yolk sac" [CL:0002354]
synonym: "abnormal yolk sac haematopoietic stem cell morphology" EXACT []
is_a: MP:0004808 ! abnormal hematopoietic stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:25:55Z

[Term]
id: MP:0011248
name: visceral organ asymmetry
def: "lateral duplication of some or all internal organs" [PMID:10646794]
is_a: MP:0004133 ! heterotaxia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-07-27T03:43:10Z

[Term]
id: MP:0011249
name: abdominal situs inversus
def: "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:3816
is_a: MP:0031284 ! abdominal situs abnormality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T10:53:02Z

[Term]
id: MP:0011250
name: abdominal situs ambiguus
def: "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [https://orcid.org/0000-0003-3691-0324, PMID:18039396]
subset: CvDC_Terms
synonym: "abdominal heterotaxy" EXACT []
synonym: "abdominal situs ambiguous" EXACT []
xref: Fyler:3817
is_a: MP:0031284 ! abdominal situs abnormality
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T11:26:30Z

[Term]
id: MP:0011251
name: bronchial situs inversus
def: "anomaly in the asymmetry of the bronchi of the lung such that these structures on both the left and right side have the morphology normally seen on the opposite side of the body" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:4237
is_a: MP:0010854 ! lung situs inversus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T11:29:01Z

[Term]
id: MP:0011252
name: situs inversus totalis
def: "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "situs inversus with dextrocardia" EXACT []
xref: Fyler:0100
xref: Fyler:100
is_a: MP:0002766 ! situs inversus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T11:31:07Z

[Term]
id: MP:0011253
name: situs inversus with levocardia
def: "situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: The term "levocardia" can also be used to indicate the absence of dextrocardia, and thus normal positioning of the heart, part of situs solitus, normal positioning of the organs. However, this usage is less frequent.
subset: CvDC_Terms
synonym: "levocardia" BROAD []
xref: Fyler:0102
xref: Fyler:102
xref: MPATH:714
is_a: MP:0002766 ! situs inversus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T11:36:01Z

[Term]
id: MP:0011254
name: superior-inferior ventricles
def: "an abnormality in which the heart ventricles are in a superior-inferior relationship due to abnormal displacement of the ventricular mass along the horizontal plane of its long axis; this frequently occurs together with criss-cross atrio-ventricular relationships" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "over-and-under ventricles" EXACT []
synonym: "supero-inferior heart" EXACT []
synonym: "upstairs-downstairs heart" EXACT []
xref: Fyler:0184
xref: Fyler:184
is_a: MP:0005294 ! abnormal heart ventricle morphology
is_a: MP:0006065 ! abnormal heart position or orientation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-09T12:00:47Z

[Term]
id: MP:0011255
name: abnormal anterior visceral endoderm cell migration
def: "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [https://orcid.org/0000-0003-3691-0324, PMID:17078044]
synonym: "abnormal AVE cell migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0012028 ! abnormal visceral endoderm physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-12T02:42:33Z

[Term]
id: MP:0011256
name: abnormal neural fold morphology
def: "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
subset: IMPC_Prenatal
synonym: "abnormal medullary fold morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-12T03:41:17Z

[Term]
id: MP:0011257
name: abnormal head fold morphology
def: "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
comment: Head fold is properly used to describe the rostrally located, crescent shaped fold of the embryonic disc around the future foregut. However, it is often (and incorrectly) used as a synonym for the ventrally located cephalic neural folds. Take care to select the correct term.
synonym: "abnormal headfold morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-12T03:49:42Z

[Term]
id: MP:0011258
name: abnormal tail fold morphology
def: "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future caudal end of the developing embryo" [ISBN:0-683-40008-8]
synonym: "abnormal caudal fold morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-12T03:49:57Z

[Term]
id: MP:0011259
name: abnormal cephalic neural fold morphology
def: "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
comment: Head fold is properly used to describe the rostrally located, crescent shaped fold of the embryonic disc around the future foregut. However, it is often (and incorrectly) used as a synonym for the ventrally located cephalic neural folds. Take care to select the correct term.
synonym: "abnormal anterior neural fold morphology" EXACT []
synonym: "abnormal cranial neural fold morphology" EXACT []
synonym: "abnormal head fold morphology" BROAD []
synonym: "abnormal headfold morphology" BROAD []
is_a: MP:0011256 ! abnormal neural fold morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-12T04:05:08Z

[Term]
id: MP:0011260
name: abnormal head mesenchyme morphology
def: "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
synonym: "abnormal cephalic mesenchyme morphology" EXACT []
synonym: "abnormal cranial mesenchyme morphology" EXACT []
is_a: MP:0006301 ! abnormal mesenchyme morphology
is_a: MP:0012176 ! abnormal head development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T11:23:04Z

[Term]
id: MP:0011261
name: abnormal limb mesenchyme morphology
def: "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal limb bud mesenchyme" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T11:41:26Z

[Term]
id: MP:0011262
name: abnormal pharyngeal arch mesenchyme morphology
def: "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal branchial arch mesenchyme morphology" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology
is_a: MP:0011260 ! abnormal head mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T11:46:26Z

[Term]
id: MP:0011263
name: abnormal spleen mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0009323 ! abnormal spleen development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T12:15:12Z

[Term]
id: MP:0011264
name: abnormal cardiac mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002925 ! abnormal cardiovascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T12:38:32Z

[Term]
id: MP:0011265
name: abnormal pancreas mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0003934 ! abnormal pancreas development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T12:41:20Z

[Term]
id: MP:0011266
name: abnormal frontonasal mesenchyme morphology
def: "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal fronto-nasal mesenchyme morphology" EXACT []
synonym: "abnormal naso-frontal mesenchyme morphology" EXACT []
is_a: MP:0011260 ! abnormal head mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T12:45:23Z

[Term]
id: MP:0011267
name: abnormal excitatory postsynaptic current amplitude
def: "anomaly in the size (height or maximum displacement) or shape of the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal excitatory post-synaptic current amplitude" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011268
name: biphasic excitatory postsynaptic current amplitude
def: "the appearance of two peaks instead of one peak in the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "biphasic excitatory post-synaptic current amplitude" EXACT []
is_a: MP:0011267 ! abnormal excitatory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011269
name: increased excitatory postsynaptic current amplitude
def: "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased excitatory post-synaptic current amplitude" EXACT []
is_a: MP:0011267 ! abnormal excitatory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011270
name: decreased excitatory postsynaptic current amplitude
def: "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased excitatory post-synaptic current amplitude" EXACT []
synonym: "reduced excitatory post-synaptic current amplitude" EXACT []
synonym: "reduced excitatory postsynaptic current amplitude" EXACT []
is_a: MP:0011267 ! abnormal excitatory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011271
name: prolonged excitatory postsynaptic current rise time
def: "an increase in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "prolonged excitatory post-synaptic current rise time" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011272
name: short excitatory postsynaptic current rise time
def: "a decrease in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "short excitatory post-synaptic current rise time" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011273
name: prolonged excitatory postsynaptic current decay time
def: "increase in the retention time of extracellular glutamate following stimulation" [PMID:26657011]
synonym: "prolonged excitatory post-synaptic current decay time" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011274
name: short excitatory postsynaptic current decay time
def: "decrease in the retention time of extracellular glutamate following stimulation" [PMID:26657011]
synonym: "short excitatory post-synaptic current decay time" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T01:39:03Z

[Term]
id: MP:0011275
name: abnormal behavioral response to light
def: "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
synonym: "abnormal behavioural response to light" EXACT []
is_a: MP:0004924 ! abnormal behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-09-13T02:14:19Z

[Term]
id: MP:0011276
name: increased tail pigmentation
def: "visually detectable excess of pigment present on the tail surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "tail hyperpigmentation" EXACT []
is_a: MP:0001188 ! hyperpigmentation
is_a: MP:0005174 ! abnormal tail pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:11:58Z

[Term]
id: MP:0011277
name: decreased tail pigmentation
def: "visually detectable dilution of pigment present on the tail surface" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced tail pigmentation" EXACT []
synonym: "tail hypopigmentation" EXACT []
is_a: MP:0005174 ! abnormal tail pigmentation
is_a: MP:0005408 ! hypopigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:12:40Z

[Term]
id: MP:0011278
name: increased ear pigmentation
def: "visually detectable excess of pigment present in the outer ear" [https://orcid.org/0000-0003-3691-0324]
synonym: "ear hyperpigmentation" EXACT []
is_a: MP:0000015 ! abnormal ear pigmentation
is_a: MP:0001188 ! hyperpigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:14:48Z

[Term]
id: MP:0011279
name: decreased ear pigmentation
def: "visually detectable dilution of pigment present in the outer ear" [https://orcid.org/0000-0003-3691-0324]
synonym: "ear hypopigmentation" EXACT []
synonym: "pale ear" RELATED []
synonym: "reduced ear pigmentation" EXACT []
is_a: MP:0000015 ! abnormal ear pigmentation
is_a: MP:0005408 ! hypopigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:14:48Z

[Term]
id: MP:0011280
name: abnormal flank coat pigmentation
def: "irregular or unusual pigmentation of the hair between the last rib and the hip" [MGI:llw2]
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:33:09Z

[Term]
id: MP:0011281
name: abnormal olfactory epithelium cilium morphology
def: "any structural anomaly of the cilia of the epithelial cells that line the interior of the nose" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal olfactory epithelium cilia morphology" EXACT []
is_a: MP:0008789 ! abnormal olfactory epithelium morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T11:36:01Z

[Term]
id: MP:0011282
name: increased podocyte apoptosis
def: "increase in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased glomerular epithelial cell apoptosis" EXACT []
synonym: "increased visceral epithelial cell apoptosis" EXACT []
is_a: MP:0011368 ! increased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:29:19Z

[Term]
id: MP:0011283
name: abnormal erythropoietin level
def: "anomalous fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal erythropoetin level" EXACT []
synonym: "abnormal erythropoietic hormone level" EXACT []
synonym: "abnormal haematopoietin level" EXACT []
synonym: "abnormal haemopoietin level" EXACT []
synonym: "abnormal hematopoietin level" EXACT []
synonym: "abnormal hemopoietin level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:33:41Z

[Term]
id: MP:0011284
name: abnormal circulating erythropoietin level
def: "anomalous blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal erythropoetin circulating level" EXACT []
synonym: "abnormal erythropoietic hormone circulating level" EXACT []
synonym: "abnormal haematopoietin circulating level" EXACT []
synonym: "abnormal haemopoietin circulating level" EXACT []
synonym: "abnormal hematopoietin circulating level" EXACT []
synonym: "abnormal hemopoietin circulating level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0011283 ! abnormal erythropoietin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:34:31Z

[Term]
id: MP:0011285
name: increased circulating erythropoietin level
def: "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased erythropoetin circulating level" EXACT []
synonym: "increased erythropoietic hormone circulating level" EXACT []
synonym: "increased haematopoietin circulating level" EXACT []
synonym: "increased haemopoietin circulating level" EXACT []
synonym: "increased hematopoietin circulating level" EXACT []
synonym: "increased hemopoietin circulating level" EXACT []
is_a: MP:0011284 ! abnormal circulating erythropoietin level
is_a: MP:0011287 ! increased erythropoietin level
is_a: MP:0014456 ! increased circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:35:50Z

[Term]
id: MP:0011286
name: decreased circulating erythropoietin level
def: "reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased erythropoetin circulating level" EXACT []
synonym: "decreased erythropoietic hormone circulating level" EXACT []
synonym: "decreased haematopoietin circulating level" EXACT []
synonym: "decreased haemopoietin circulating level" EXACT []
synonym: "decreased hematopoietin circulating level" EXACT []
synonym: "decreased hemopoietin circulating level" EXACT []
synonym: "reduced erythropoetin circulating level" EXACT []
synonym: "reduced erythropoietic hormone circulating level" EXACT []
synonym: "reduced haematopoietin circulating level" EXACT []
synonym: "reduced haemopoietin circulating level" EXACT []
synonym: "reduced hematopoietin circulating level" EXACT []
synonym: "reduced hemopoietin circulating level" EXACT []
is_a: MP:0011284 ! abnormal circulating erythropoietin level
is_a: MP:0011288 ! decreased erythropoietin level
is_a: MP:0014457 ! decreased circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:35:50Z

[Term]
id: MP:0011287
name: increased erythropoietin level
def: "greater fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "increased erythropoetin level" EXACT []
synonym: "increased erythropoietic hormone level" EXACT []
synonym: "increased haematopoietin level" EXACT []
synonym: "increased haemopoietin level" EXACT []
synonym: "increased hematopoietin level" EXACT []
synonym: "increased hemopoietin level" EXACT []
is_a: MP:0011283 ! abnormal erythropoietin level
is_a: MP:0014454 ! increased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:35:50Z

[Term]
id: MP:0011288
name: decreased erythropoietin level
def: "reduced fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "decreased erythropoetin level" EXACT []
synonym: "decreased erythropoietic hormone level" EXACT []
synonym: "decreased haematopoietin level" EXACT []
synonym: "decreased haemopoietin level" EXACT []
synonym: "decreased hematopoietin level" EXACT []
synonym: "decreased hemopoietin level" EXACT []
synonym: "reduced erythropoetin level" EXACT []
synonym: "reduced erythropoietic hormone level" EXACT []
synonym: "reduced haematopoietin level" EXACT []
synonym: "reduced haemopoietin level" EXACT []
synonym: "reduced hematopoietin level" EXACT []
synonym: "reduced hemopoietin level" EXACT []
is_a: MP:0011283 ! abnormal erythropoietin level
is_a: MP:0014455 ! decreased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T02:35:50Z

[Term]
id: MP:0011289
name: abnormal nephron number
def: "anomaly in the total number of the filtering units of the kidney; nephron number can be used as an index of the efficiency of ureteric branching and nephrogenesis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003881 ! abnormal nephron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:49:41Z

[Term]
id: MP:0011290
name: decreased nephron number
def: "reduction in the total number of filtering units of the kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "oligonephronia" EXACT []
synonym: "reduced nephron endowment" EXACT []
synonym: "reduced nephron number" EXACT []
is_a: MP:0011289 ! abnormal nephron number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:49:41Z

[Term]
id: MP:0011291
name: nephron necrosis
def: "morphological changes resulting from pathological death of nephron tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "necrotic nephron" EXACT []
synonym: "necrotic nephrons" EXACT []
is_a: MP:0003881 ! abnormal nephron morphology
is_a: MP:0003946 ! renal necrosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:49:41Z

[Term]
id: MP:0011292
name: absent nephron
def: "complete absence of functional filtering units in the kidney" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003881 ! abnormal nephron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:49:41Z

[Term]
id: MP:0011293
name: dilated nephron
def: "stretched or widened aperture of the luminal space of one or more of the filtering units of the kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated nephrons" EXACT []
synonym: "nephron dilation" EXACT []
is_a: MP:0003881 ! abnormal nephron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:49:41Z

[Term]
id: MP:0011294
name: renal glomerulus hypertrophy
def: "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic glomerular capillaries" EXACT []
synonym: "hypertrophic renal glomeruli" EXACT []
synonym: "renal glomerular hypertrophy" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:52:43Z

[Term]
id: MP:0011295
name: abnormal tubuloglomerular feedback response
def: "any anomaly in the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal TGF response" EXACT []
synonym: "abnormal tubuloglomerular feedback mechanism" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:56:31Z

[Term]
id: MP:0011296
name: decreased tubuloglomerular feedback response
def: "attenuation of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired tubuloglomerular feedback mechanism" EXACT []
synonym: "reduced TGF response" EXACT []
is_a: MP:0011295 ! abnormal tubuloglomerular feedback response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:58:00Z

[Term]
id: MP:0011297
name: absent tubuloglomerular feedback response
def: "absence of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent TGF response" EXACT []
is_a: MP:0011295 ! abnormal tubuloglomerular feedback response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T03:58:00Z

[Term]
id: MP:0011298
name: ureter hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ureter, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic ureter" EXACT []
synonym: "rudimentary ureter" EXACT []
synonym: "ureteric hypoplasia" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:00:19Z

[Term]
id: MP:0011299
name: abnormal macula densa morphology
def: "any structural anomaly of the specialized group of densely packed epithelial cells marking the origin of the convoluted portion of the distal tubule of a nephron, in contact with the afferent arteriole of the renal corpuscle and contiguous with the juxtaglomerular cells; these cells are tall, thin and columnar, have prominent nuclei, and act as sensors of solute concentration and flow of tubular fluid" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002829 ! abnormal juxtaglomerular apparatus morphology
is_a: MP:0004757 ! abnormal distal convoluted tubule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:01:54Z

[Term]
id: MP:0011300
name: abnormal juxtaglomerular cell morphology
def: "any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal (renal) granular cell morphology" EXACT []
synonym: "abnormal J-G cell morphology" EXACT []
is_a: MP:0002829 ! abnormal juxtaglomerular apparatus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:05:39Z

[Term]
id: MP:0011301
name: juxtaglomerular cell hyperplasia
def: "increased number of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic juxtaglomerular cells" EXACT []
synonym: "hyperplastic renal granular cells" EXACT []
synonym: "J-G cell hyperplasia" EXACT []
is_a: MP:0011300 ! abnormal juxtaglomerular cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:05:39Z

[Term]
id: MP:0011302
name: abnormal extraglomerular mesangial cell morphology
def: "any structural anomaly of the light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa; lacis cells form the juxtaglomerular apparatus in combination with two other types of cells: the macula densa of the distal convoluted tubule and juxtaglomerular cells of the afferent arteriole" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Goormaghtigh cell morphology" EXACT []
synonym: "abnormal lacis cell morphology" EXACT []
is_a: MP:0002829 ! abnormal juxtaglomerular apparatus morphology
is_a: MP:0011340 ! abnormal extraglomerular mesangium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:05:39Z

[Term]
id: MP:0011303
name: absent kidney papilla
def: "absence of the apex (tip) of a renal pyramid i.e. the location where each medullary pyramid empties urine into a minor calyx" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent kidney papillae" EXACT []
synonym: "absent renal papilla" EXACT []
is_a: MP:0004193 ! abnormal kidney papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:08:05Z

[Term]
id: MP:0011304
name: kidney papillary atrophy
def: "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophied kidney papilla" EXACT []
synonym: "renal papillary atrophy" EXACT []
is_a: MP:0004193 ! abnormal kidney papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:08:05Z

[Term]
id: MP:0011305
name: dilated kidney calyx
def: "an expansion in the lumen volume or area of one or more of the branches of the renal pelvis that surround each renal papilla and collect urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated kidney calyces" EXACT []
synonym: "dilated renal calyces" EXACT []
synonym: "dilated renal calyx" EXACT []
synonym: "kidney calyceal dilation" EXACT []
synonym: "kidney calyx dilation" EXACT []
synonym: "renal calyceal dilation" EXACT []
synonym: "renal calyx dilation" EXACT []
is_a: MP:0004195 ! abnormal kidney calyx morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:14:15Z

[Term]
id: MP:0011306
name: absent kidney pelvis
def: "absence of the funnel shaped proximal portion of the ureter, normally formed by convergence of the major calices" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent renal pelvis" EXACT []
is_a: MP:0004194 ! abnormal kidney pelvis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:15:16Z

[Term]
id: MP:0011307
name: kidney medulla cyst
def: "presence of one or more abnormal membranous sacs in the kidney medulla" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic kidney medulla" EXACT []
synonym: "cystic renal medulla" EXACT []
synonym: "kidney medulla cysts" EXACT []
synonym: "renal medulla cyst" EXACT []
synonym: "renal medulla cysts" EXACT []
synonym: "renal medullary cyst" EXACT []
synonym: "renal medullary cysts" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology
is_a: MP:0003675 ! kidney cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:18:37Z

[Term]
id: MP:0011308
name: kidney corticomedullary cyst
def: "presence of one or more abnormal membranous sacs in the corticomedullary junction of the kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic kidney corticomedullary boundary" EXACT []
synonym: "cystic kidney corticomedullary junction" EXACT []
synonym: "kidney cortico-medullary cyst" EXACT []
synonym: "kidney cortico-medullary cysts" EXACT []
synonym: "kidney corticomedullary cysts" EXACT []
synonym: "renal corticomedullary cyst" EXACT []
synonym: "renal corticomedullary cysts" EXACT []
is_a: MP:0003675 ! kidney cyst
is_a: MP:0011376 ! abnormal kidney corticomedullary boundary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-11T04:19:29Z

[Term]
id: MP:0011309
name: abnormal kidney arterial blood vessel morphology
def: "any structural anomaly of the network of tubes that supply blood to the renal tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000530 ! abnormal kidney vasculature morphology
is_a: MP:0011655 ! abnormal systemic artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:45:11Z

[Term]
id: MP:0011310
name: abnormal kidney capillary morphology
def: "any structural anomaly of the small branching blood vessels in the kidney that form a network between the arterioles and venules, where the exchange of water, oxygen, carbon dioxide, and other nutrient and waste chemical substances occurs between the blood and the surrounding tissues" [http://en.wikipedia.org/wiki/Capillary, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000530 ! abnormal kidney vasculature morphology
is_a: MP:0003658 ! abnormal capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:46:04Z

[Term]
id: MP:0011311
name: abnormal kidney venous blood vessel morphology
def: "any structural anomaly of the network of tubes that return blood from the renal tissues to the systemic circulation" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000530 ! abnormal kidney vasculature morphology
is_a: MP:0002725 ! abnormal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:46:27Z

[Term]
id: MP:0011312
name: abnormal kidney afferent arteriole morphology
def: "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal renal afferent arteriole morphology" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology
is_a: MP:0011309 ! abnormal kidney arterial blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:47:23Z

[Term]
id: MP:0011313
name: abnormal kidney efferent arteriole morphology
def: "any structural anomaly of the blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal renal efferent arteriole morphology" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology
is_a: MP:0011309 ! abnormal kidney arterial blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:47:58Z

[Term]
id: MP:0011314
name: abnormal kidney cortex artery morphology
def: "any structural anomaly of the network of tubes that supplies blood to the renal cortex" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal renal cortex arterial system morphology" EXACT []
synonym: "abnormal renal cortex artery morphology" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
is_a: MP:0011309 ! abnormal kidney arterial blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:48:36Z

[Term]
id: MP:0011315
name: abnormal kidney arcuate artery morphology
def: "any structural anomaly of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries" [ISBN:0-683-40008-8]
synonym: "abnormal arcuate artery morphology" EXACT []
synonym: "abnormal renal arcuate artery morphology" EXACT []
is_a: MP:0011314 ! abnormal kidney cortex artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:49:41Z

[Term]
id: MP:0011316
name: abnormal kidney interlobular artery morphology
def: "any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]
synonym: "abnormal cortical radiate arteries morphology" EXACT []
synonym: "abnormal cortical radiate artery morphology" EXACT []
synonym: "abnormal interlobular artery morphology" EXACT []
synonym: "abnormal interlobular artery of kidney morphology" RELATED []
synonym: "abnormal renal interlobular artery morphology" EXACT []
is_a: MP:0011314 ! abnormal kidney cortex artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:49:41Z

[Term]
id: MP:0011317
name: abnormal renal artery morphology
def: "any structural anomaly of the pair of major vessels which arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood; small branches of the renal artery also supply the suprarenal gland, the ureter and some surrounding tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011309 ! abnormal kidney arterial blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:50:57Z

[Term]
id: MP:0011318
name: abnormal right renal artery morphology
def: "any structural anomaly of the major vessel which arises off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supplies the right kidney with blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011317 ! abnormal renal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:51:25Z

[Term]
id: MP:0011319
name: abnormal left renal artery morphology
def: "any structural anomaly of the major vessel which arises off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supplies the left kidney with blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011317 ! abnormal renal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T01:51:46Z

[Term]
id: MP:0011320
name: abnormal glomerular capillary morphology
def: "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal glomerulus capillary morphology" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
is_a: MP:0011310 ! abnormal kidney capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:18:30Z

[Term]
id: MP:0011321
name: abnormal peritubular capillary morphology
def: "any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011310 ! abnormal kidney capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:18:59Z

[Term]
id: MP:0011322
name: abnormal kidney cortex vein morphology
def: "any structural anomaly of the network of tubes that receives blood from the renal cortex" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal renal cortex vein morphology" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
is_a: MP:0011311 ! abnormal kidney venous blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:21:27Z

[Term]
id: MP:0011323
name: abnormal renal vein morphology
def: "any structural anomaly of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0011311 ! abnormal kidney venous blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:21:27Z

[Term]
id: MP:0011324
name: abnormal kidney vasa recta morphology
def: "any structural anomaly in the straight arteries and arterioles that form a series of straight capillaries in the kidney medulla" [http://purl.obolibrary.org/obo/UBERON_0004726]
is_a: MP:0000530 ! abnormal kidney vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:21:27Z

[Term]
id: MP:0011325
name: abnormal kidney arcuate vein morphology
def: "any structural anomaly of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins" [ISBN:0-683-40008-8]
synonym: "abnormal arciform veins of kidney morphology" EXACT []
synonym: "abnormal arcuate vein morphology" BROAD []
synonym: "abnormal arcuate veins of kidney morphology" EXACT []
synonym: "abnormal renal arcuate vein morphology" EXACT []
synonym: "abnormal venae arcuatae renis morphology" EXACT []
is_a: MP:0011322 ! abnormal kidney cortex vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:22:12Z

[Term]
id: MP:0011326
name: abnormal interlobular vein morphology
def: "any structural anomaly of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins" [ISBN:0-683-40008-8]
is_a: MP:0011322 ! abnormal kidney cortex vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:22:12Z

[Term]
id: MP:0011327
name: abnormal left renal vein morphology
def: "any structural anomaly of the longer of the two renal veins that receives blood from the left kidney; the left renal vein usually receives the left inferior phrenic vein, the left suprarenal vein, the left gonadal vein (left testicular vein in males, left ovarian vein in females) and the left second lumbar vein whereas these veins on the right side drain directly into the inferior vena cava" [ISBN:0-683-40008-8]
is_a: MP:0011323 ! abnormal renal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:26:43Z

[Term]
id: MP:0011328
name: abnormal right renal vein morphology
def: "any structural anomaly of the shorter of the two renal veins that receives blood from the right kidney; the left renal vein usually receives the left inferior phrenic vein, the left suprarenal vein, the left gonadal vein (left testicular vein in males, left ovarian vein in females) and the left second lumbar vein whereas these veins on the right side drain directly into the inferior vena cava" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0011323 ! abnormal renal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:27:00Z

[Term]
id: MP:0011329
name: abnormal inner renal medulla vasa recta morphology
def: "any structural anomaly in the vasa recta in the inner renal medulla" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011324 ! abnormal kidney vasa recta morphology
is_a: MP:0011333 ! abnormal kidney inner medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:27:33Z

[Term]
id: MP:0011330
name: abnormal kidney outer medulla vasa recta morphology
def: "any structural anomaly in the vasa recta in the kidney outer medulla" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011324 ! abnormal kidney vasa recta morphology
is_a: MP:0011332 ! abnormal kidney outer medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:28:50Z

[Term]
id: MP:0011331
name: abnormal papillary duct morphology
def: "any structural anomaly of the largest straight excretory ducts in the kidney medulla and papillae that are a continuation of the collecting tubules, and that open into the area cribosa" [ISBN:0-683-40008-8]
synonym: "abnormal Bellini's duct morphology" EXACT []
synonym: "abnormal duct of Bellini morphology" EXACT []
is_a: MP:0004754 ! abnormal kidney collecting duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T02:46:47Z

[Term]
id: MP:0011332
name: abnormal kidney outer medulla morphology
def: "any structural anomaly of the outer medullary region of the adult kidney containing the short Loops of Henle and collecting ducts" [https://orcid.org/0000-0003-3691-0324, PMID:20614633]
is_a: MP:0003014 ! abnormal kidney medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:44:46Z

[Term]
id: MP:0011333
name: abnormal kidney inner medulla morphology
def: "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [https://orcid.org/0000-0003-3691-0324, PMID:20614633]
is_a: MP:0003014 ! abnormal kidney medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:44:46Z

[Term]
id: MP:0011334
name: abnormal nephrogenic zone morphology
def: "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
is_a: MP:0000527 ! abnormal kidney development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:48:15Z

[Term]
id: MP:0011335
name: abnormal kidney pelvis smooth muscle morphology
def: "any structural anomaly of the smooth muscle tissue surrounding the urothelium of the kidney pelvis" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004194 ! abnormal kidney pelvis morphology
is_a: MP:0011426 ! abnormal ureter smooth muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:48:15Z

[Term]
id: MP:0011336
name: abnormal kidney pelvis urothelium morphology
def: "any structural anomaly of the epithelial lining of the luminal space of the kidney pelvis" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal kidney pelvis endothelium morphology" EXACT []
synonym: "abnormal kidney pelvis urothelial lining morphology" EXACT []
synonym: "abnormal renal pelvis urothelium morphology" EXACT []
is_a: MP:0003630 ! abnormal urothelium morphology
is_a: MP:0004194 ! abnormal kidney pelvis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:48:15Z

[Term]
id: MP:0011337
name: abnormal perihilar interstitium morphology
def: "any structural anomaly of the part of the renal interstitium surrounding the pelvis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011425 ! abnormal kidney interstitium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:48:15Z

[Term]
id: MP:0011338
name: abnormal mesangial matrix morphology
def: "any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ECM morphology" BROAD []
synonym: "abnormal extracellular mesangial matrix morphology" EXACT []
synonym: "mesangial extracellular matrix morphology" EXACT []
is_a: MP:0011339 ! abnormal glomerular mesangium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T03:58:27Z

[Term]
id: MP:0011339
name: abnormal glomerular mesangium morphology
def: "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [https://orcid.org/0000-0003-3691-0324]
xref: MA:0002606
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T04:00:09Z

[Term]
id: MP:0011340
name: abnormal extraglomerular mesangium morphology
def: "any structural anomaly of the tissue comprised of mesangial cells that fill the triangular space between the macula densa and the afferent and efferent arterioles of the juxtaglomerular apparatus" [ISBN:0-683-40008-8]
synonym: "abnormal polkissen of Zimmermann morphology" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-12T04:01:37Z

[Term]
id: MP:0011341
name: abnormal loop of Henle descending limb morphology
def: "any structural anomaly of the portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ansa nephroni descending limb morphology" EXACT []
synonym: "abnormal descending limb of Henle's loop morphology" EXACT []
synonym: "abnormal descending limb of loop of Henle morphology" EXACT []
synonym: "abnormal descending loop of Henle morphology" EXACT []
xref: MA:0001679
is_a: MP:0004755 ! abnormal loop of Henle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-13T09:44:50Z

[Term]
id: MP:0011342
name: abnormal loop of Henle ascending limb morphology
def: "any structural anomaly of the distal part of the loop of Henle that is impermeable to water and actively pumps sodium out of the filtrate to generate the hypertonic interstitium that drives countercurrent exchange; it consists of an initial very thin segment lined by simple squamous epithelium followed by a distal thick segment lined by simple cuboidal epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ansa nephroni ascending limb morphology" EXACT []
synonym: "abnormal ascending limb of Henle's loop morphology" EXACT []
synonym: "abnormal ascending limb of loop of Henle morphology" EXACT []
synonym: "abnormal ascending loop of Henle morphology" EXACT []
xref: MA:0001676
is_a: MP:0004755 ! abnormal loop of Henle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-13T09:44:50Z

[Term]
id: MP:0011343
name: abnormal loop of Henle ascending limb thin segment morphology
def: "any structural anomaly of the initial sub-portion of the ascending loop of Henle localized in the juxtamedullary nephron of the kidney; it is lined by simple squamous epithelium, impermeable to water but permeable to ions and other small particles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ansa nephroni ascending limb thin segment morphology" EXACT []
synonym: "abnormal thin ascending limb of Henle's loop morphology" EXACT []
synonym: "abnormal thin ascending limb of loop of Henle morphology" EXACT []
xref: MA:0001678
is_a: MP:0011342 ! abnormal loop of Henle ascending limb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-13T09:44:50Z

[Term]
id: MP:0011344
name: abnormal loop of Henle ascending limb thick segment morphology
def: "any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ansa nephroni ascending limb thick segment morphology" EXACT []
synonym: "abnormal distal straight tubule morphology" EXACT []
synonym: "abnormal thick ascending limb of Henle's loop morphology" EXACT []
synonym: "abnormal thick ascending limb of loop of Henle morphology" EXACT []
xref: MA:0001677
is_a: MP:0011342 ! abnormal loop of Henle ascending limb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-13T09:44:50Z

[Term]
id: MP:0011345
name: truncated loop of Henle
def: "failure of the developing loop of Henle to elongate and extend into the medullary zone of the kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "truncated ansa nephroni" EXACT []
is_a: MP:0004755 ! abnormal loop of Henle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-13T09:44:50Z

[Term]
id: MP:0011346
name: renal tubule atrophy
def: "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic renal tubules" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology
is_a: MP:0004970 ! kidney atrophy
property_value: terms:contributor https://www.wikidata.org/wiki/Q1951035
created_by: mgi
creation_date: 2011-10-14T06:33:12Z

[Term]
id: MP:0011347
name: abnormal kidney medullary ray morphology
def: "any structural anomaly in the center of a renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnomal kidney cortical medullary ray morphology" EXACT []
synonym: "abnormal Ferrein's pyramid morphology" EXACT []
synonym: "abnormal renal medullary ray morphology" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T10:08:04Z

[Term]
id: MP:0011348
name: abnormal renal glomerulus basement membrane morphology
def: "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal GBM morphology" EXACT []
synonym: "abnormal glomerular basement membrane morphology" EXACT []
synonym: "abnormal glomerulus basement membrane morphology" EXACT []
synonym: "abnormal kidney glomerulus basement membrane morphology" EXACT []
is_a: MP:0002827 ! abnormal renal corpuscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T10:29:55Z

[Term]
id: MP:0011349
name: abnormal renal glomerulus basement membrane thickness
def: "increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal GBM thickness" EXACT []
synonym: "abnormal glomerular basement membrane thickness" EXACT []
synonym: "abnormal glomerulus basement membrane thickness" EXACT []
synonym: "abnormal kidney glomerulus basement membrane thickness" EXACT []
is_a: MP:0011348 ! abnormal renal glomerulus basement membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T10:35:12Z

[Term]
id: MP:0011350
name: abnormal proximal convoluted tubule brush border morphology
def: "any structural anomaly of the densely packed microvilli that cover the luminal surface of epithelial cells of the proximal convoluted tubule; microvilli increase the luminal surface area of cells, sense the fluid flow in the tubule lumen and convert this information via biochemical responses into reabsorption" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney apical microvillus border morphology" EXACT []
synonym: "abnormal kidney apical microvillus striated border morphology" EXACT []
synonym: "abnormal kidney brush border microvilli morphology" EXACT []
synonym: "abnormal kidney brush border morphology" EXACT []
synonym: "abnormal kidney striated border microvilli morphology" EXACT []
synonym: "abnormal kidney striated border morphology" EXACT []
synonym: "abnormal kidney tubular brush border morphology" EXACT []
synonym: "abnormal kidney tubular striated border morphology" EXACT []
synonym: "abnormal kidney tubule brush border morphology" EXACT []
synonym: "abnormal kidney tubule striated border morphology" EXACT []
synonym: "abnormal renal brush border microvilli morphology" EXACT []
synonym: "abnormal renal brush border morphology" EXACT []
synonym: "abnormal renal microvillus border morphology" EXACT []
synonym: "abnormal renal microvillus striated border morphology" EXACT []
synonym: "abnormal renal proximal tubular brush border morphology" EXACT []
synonym: "abnormal renal proximal tubular striated border morphology" EXACT []
synonym: "abnormal renal proximal tubule brush border morphology" EXACT []
synonym: "abnormal renal proximal tubule striated border morphology" EXACT []
synonym: "abnormal renal striated border microvilli morphology" EXACT []
synonym: "abnormal renal striated border morphology" EXACT []
synonym: "abnormal renal tubular brush border morphology" EXACT []
synonym: "abnormal renal tubular striated border morphology" EXACT []
synonym: "abnormal renal tubule brush border morphology" EXACT []
synonym: "abnormal renal tubule striated border morphology" EXACT []
is_a: MP:0004756 ! abnormal proximal convoluted tubule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T11:26:48Z

[Term]
id: MP:0011351
name: absent proximal convoluted tubule brush border
def: "failure to form a brush border of densely packed microvilli on the luminal surface of epithelial cells of the proximal convoluted tubule" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent kidney apical microvillus border" EXACT []
synonym: "absent kidney apical microvillus striated border" EXACT []
synonym: "absent kidney brush border" EXACT []
synonym: "absent kidney brush border microvilli" EXACT []
synonym: "absent kidney striated border" EXACT []
synonym: "absent kidney striated border microvilli" EXACT []
synonym: "absent kidney tubular brush border" EXACT []
synonym: "absent kidney tubular striated border" EXACT []
synonym: "absent kidney tubule brush border" EXACT []
synonym: "absent kidney tubule striated border" EXACT []
synonym: "absent renal brush border" EXACT []
synonym: "absent renal brush border microvilli" EXACT []
synonym: "absent renal microvillus border" EXACT []
synonym: "absent renal microvillus striated border" EXACT []
synonym: "absent renal proximal tubular brush border" EXACT []
synonym: "absent renal proximal tubular striated border" EXACT []
synonym: "absent renal proximal tubule brush border" EXACT []
synonym: "absent renal proximal tubule striated border" EXACT []
synonym: "absent renal striated border" EXACT []
synonym: "absent renal striated border microvilli" EXACT []
synonym: "absent renal tubular brush border" EXACT []
synonym: "absent renal tubular striated border" EXACT []
synonym: "absent renal tubule brush border" EXACT []
synonym: "absent renal tubule striated border" EXACT []
is_a: MP:0011350 ! abnormal proximal convoluted tubule brush border morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T11:33:29Z

[Term]
id: MP:0011352
name: proximal convoluted tubule brush border loss
def: "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney apical microvillus border loss" EXACT []
synonym: "kidney apical microvillus striated border loss" EXACT []
synonym: "kidney brush border loss" EXACT []
synonym: "kidney brush border microvilli loss" EXACT []
synonym: "kidney striated border loss" EXACT []
synonym: "kidney striated border microvilli loss" EXACT []
synonym: "kidney tubular brush border loss" EXACT []
synonym: "kidney tubular striated border loss" EXACT []
synonym: "kidney tubule brush border loss" EXACT []
synonym: "kidney tubule striated border loss" EXACT []
synonym: "renal brush border loss" EXACT []
synonym: "renal brush border microvilli loss" EXACT []
synonym: "renal microvillus border loss" EXACT []
synonym: "renal microvillus striated border loss" EXACT []
synonym: "renal proximal tubular brush border loss" EXACT []
synonym: "renal proximal tubular striated border loss" EXACT []
synonym: "renal proximal tubule brush border loss" EXACT []
synonym: "renal proximal tubule striated border loss" EXACT []
synonym: "renal striated border loss" EXACT []
synonym: "renal striated border microvilli loss" EXACT []
synonym: "renal tubular brush border loss" EXACT []
synonym: "renal tubular striated border loss" EXACT []
synonym: "renal tubule brush border loss" EXACT []
synonym: "renal tubule striated border loss" EXACT []
is_a: MP:0011350 ! abnormal proximal convoluted tubule brush border morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T11:33:29Z

[Term]
id: MP:0011353
name: expanded mesangial matrix
def: "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [https://orcid.org/0000-0003-3691-0324]
synonym: "accumulated mesangial matrix" EXACT []
synonym: "expanded extracellular mesangial matrix" EXACT []
synonym: "expanded mesangial extracellular matrix" EXACT []
synonym: "increase in mesangial matrix" EXACT []
synonym: "mesangial matrix expansion" EXACT []
synonym: "mesangial sclerosis" NARROW []
synonym: "thickened mesangial matrix" EXACT []
is_a: MP:0011338 ! abnormal mesangial matrix morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T12:11:55Z

[Term]
id: MP:0011354
name: absent renal glomerulus
def: "complete absence of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit" [ISBN:0-683-40008-8]
synonym: "absent glomerular tuft" EXACT []
synonym: "absent glomeruli" EXACT []
synonym: "absent kidney glomerulus" EXACT []
synonym: "absent malpighian glomerulus" EXACT []
synonym: "absent malpighian tuft" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-14T03:51:42Z

[Term]
id: MP:0011355
name: abnormal kidney interlobar artery morphology
def: "any structural anomaly of the branches of the segmental arteries of the kidney that cross between the renal lobes and give rise to the arculate arteries in the cortex" [ISBN:0-683-40008-8]
synonym: "abnormal renal interlobar artery morphology" EXACT []
is_a: MP:0011309 ! abnormal kidney arterial blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T10:55:39Z

[Term]
id: MP:0011356
name: renal artery stenosis
def: "diffuse constriction or narrowing of one or both renal arteries" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "RAS" EXACT []
xref: Fyler:2634
is_a: MP:0006135 ! artery stenosis
is_a: MP:0011317 ! abnormal renal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T11:18:29Z

[Term]
id: MP:0011357
name: supernumerary renal arteries
def: "two or more arteries branch from the abdominal aorta and supply a single kidney" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011317 ! abnormal renal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T11:33:25Z

[Term]
id: MP:0011358
name: renal artery aneurysm
def: "a protruding sac formed by the dilation of the wall of a renal artery, resulting from a weakening of the vessel wall or heart muscle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003279 ! aneurysm
is_a: MP:0011317 ! abnormal renal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T12:03:00Z

[Term]
id: MP:0011359
name: decreased glomerular capillary number
def: "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased glomerulus capillary number" EXACT []
synonym: "reduced glomerular capillary number" EXACT []
synonym: "reduced glomerulus capillary number" EXACT []
is_a: MP:0011320 ! abnormal glomerular capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T12:12:22Z

[Term]
id: MP:0011360
name: kidney cortex hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the kidney cortex, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic kidney cortex" EXACT []
synonym: "hypoplastic renal cortex" EXACT []
synonym: "kidney cortical hypoplasia" EXACT []
synonym: "renal cortex hypoplasia" EXACT []
synonym: "renal cortical hypoplasia" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T04:11:24Z

[Term]
id: MP:0011361
name: pelvic kidney
def: "an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003600 ! ectopic kidney
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T04:14:10Z

[Term]
id: MP:0011362
name: ectopic adrenal gland
def: "an adrenal gland located outside of its normal position" [https://orcid.org/0000-0002-6490-7723]
synonym: "adrenal ectopia" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T04:16:00Z

[Term]
id: MP:0011363
name: renal glomerulus atrophy
def: "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic glomeruli" EXACT []
synonym: "shrunken glomeruli" EXACT []
is_a: MP:0004970 ! kidney atrophy
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-17T04:17:57Z

[Term]
id: MP:0011364
name: abnormal metanephros morphology
def: "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
synonym: "abnormal hind kidney morphology" EXACT []
synonym: "abnormal metanephra" EXACT []
synonym: "abnormal metanephroi" EXACT []
is_a: MP:0000527 ! abnormal kidney development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-18T04:11:52Z

[Term]
id: MP:0011365
name: small metanephros
def: "reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased metanephron size" EXACT []
synonym: "reduced metanephron size" EXACT []
synonym: "small hind kidney" EXACT []
synonym: "small metanephra" EXACT []
synonym: "small metanephroi" EXACT []
is_a: MP:0011364 ! abnormal metanephros morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-18T04:13:07Z

[Term]
id: MP:0011366
name: absent metanephros
def: "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent hind kidney" EXACT []
synonym: "absent metanephra" EXACT []
synonym: "absent metanephroi" EXACT []
is_a: MP:0011364 ! abnormal metanephros morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-18T04:13:07Z

[Term]
id: MP:0011367
name: abnormal kidney apoptosis
def: "change in the timing or the number of kidney cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal renal apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:35:55Z

[Term]
id: MP:0011368
name: increased kidney apoptosis
def: "increase in the number of cells of the kidney undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased renal apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0011367 ! abnormal kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:38:28Z

[Term]
id: MP:0011369
name: increased renal glomerulus apoptosis
def: "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased glomerular apoptosis" EXACT []
synonym: "increased glomerular cell apoptosis" EXACT []
synonym: "increased glomerulus cell apoptosis" EXACT []
is_a: MP:0011368 ! increased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:40:16Z

[Term]
id: MP:0011370
name: increased mesangial cell apoptosis
def: "increase in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased deep cell apoptosis" EXACT []
synonym: "increased intercapillary cell apoptosis" EXACT []
is_a: MP:0011368 ! increased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:41:26Z

[Term]
id: MP:0011371
name: decreased kidney apoptosis
def: "decrease in the number of cells of the kidney undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0011367 ! abnormal kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:42:06Z

[Term]
id: MP:0011372
name: decreased renal tubule apoptosis
def: "decrease in the number of renal tubule cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011371 ! decreased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:46:26Z

[Term]
id: MP:0011373
name: decreased mesangial cell apoptosis
def: "decrease in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased deep cell apoptosis" EXACT []
synonym: "decreased intercapillary cell apoptosis" EXACT []
is_a: MP:0011371 ! decreased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:46:26Z

[Term]
id: MP:0011374
name: decreased podocyte apoptosis
def: "decrease in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased glomerular epithelial cell apoptosis" EXACT []
synonym: "decreased visceral epithelial cell apoptosis" EXACT []
is_a: MP:0011371 ! decreased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:46:26Z

[Term]
id: MP:0011375
name: decreased renal glomerulus apoptosis
def: "decrease in the number of cells of the kidney glomerulus undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased glomerular apoptosis" EXACT []
synonym: "decreased glomerular cell apoptosis" EXACT []
synonym: "decreased glomerulus cell apoptosis" EXACT []
is_a: MP:0011371 ! decreased kidney apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T11:46:26Z

[Term]
id: MP:0011376
name: abnormal kidney corticomedullary boundary morphology
def: "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney corticomedullary border morphology" EXACT []
synonym: "abnormal kidney corticomedullary boundary zone" EXACT []
synonym: "abnormal kidney corticomedullary junction" EXACT []
synonym: "abnormal renal cortico-medullary border morphology" EXACT []
synonym: "abnormal renal cortico-medullary boundary zone" EXACT []
synonym: "abnormal renal cortico-medullary junction" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T12:35:50Z

[Term]
id: MP:0011377
name: renal glomerulus fibrosis
def: "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [https://orcid.org/0000-0002-6490-7723]
synonym: "fibrotic glomerular capillaries" EXACT []
synonym: "fibrotic glomeruli" EXACT []
synonym: "kidney glomerular fibrosis" EXACT []
synonym: "kidney glomerulus fibrosis" EXACT []
synonym: "renal glomerular fibrosis" EXACT []
is_a: MP:0003985 ! renal fibrosis
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T12:42:42Z

[Term]
id: MP:0011378
name: abnormal kidney outer medulla inner stripe morphology
def: "any structural anomaly of the deep, centrally located portion of the renal outer medulla that is traversed by thin descending and thick ascending portions of the loops of Henle" [GO:0072057]
is_a: MP:0011332 ! abnormal kidney outer medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T01:45:24Z

[Term]
id: MP:0011379
name: abnormal kidney outer medulla outer stripe morphology
def: "any structural anomaly of the region of the kidney outer medulla that lies just below the cortex; the proximal straight tubules are present in this region" [MP:0072058]
is_a: MP:0011332 ! abnormal kidney outer medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-19T01:47:18Z

[Term]
id: MP:0011380
name: enlarged brain ventricles
def: "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [https://orcid.org/0000-0003-4606-0597, PMID:37104040]
synonym: "brain ventriculomegaly" EXACT []
synonym: "enlarged cerebral vesicles" EXACT []
synonym: "increased brain ventricle size" EXACT []
synonym: "ventriculomegaly" BROAD []
synonym: "ventriculomegaly of the brain" EXACT []
is_a: MP:0013229 ! abnormal brain ventricle size
property_value: terms:contributor https://orcid.org/0000-0002-4154-7358
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-20T04:03:47Z

[Term]
id: MP:0011381
name: abnormal kidney lobe morphology
def: "any structural anomaly of the portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it; human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal renal lobe morphology" EXACT []
synonym: "kidney lobe dysplasia" NARROW []
synonym: "renal lobe dysplasia" NARROW []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2011-10-21T01:54:13Z

[Term]
id: MP:0011382
name: abnormal kidney lobule morphology
def: "any structural anomaly of the portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cortical lobule morphology" EXACT []
synonym: "abnormal renal lobule morphology" EXACT []
synonym: "cortical lobule dysplasia" NARROW []
synonym: "kidney lobule dysplasia" NARROW []
synonym: "renal lobule dysplasia" NARROW []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T01:55:00Z

[Term]
id: MP:0011383
name: abnormal kidney capsule morphology
def: "any structural anomaly of the tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal renal capsule morphology" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:19:54Z

[Term]
id: MP:0011384
name: abnormal progesterone level
def: "anomaly in the concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [ISBN:0-683-40008-8]
synonym: "abnormal luteohormone level" EXACT []
synonym: "abnormal pregnancy hormone level" EXACT []
synonym: "abnormal progestational level hormone" EXACT []
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:24:53Z

[Term]
id: MP:0011385
name: abnormal testosterone level
def: "anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:25:30Z

[Term]
id: MP:0011386
name: increased metanephric mesenchyme apoptosis
def: "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased metanephric blastema apoptosis" EXACT []
synonym: "increased metanephric mesoderm apoptosis" EXACT []
synonym: "increased nephric mesenchyme apoptosis" EXACT []
is_a: MP:0010984 ! abnormal metanephric mesenchyme morphology
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:42:31Z

[Term]
id: MP:0011387
name: absent metanephric mesenchyme
def: "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent metanephric blastema" EXACT []
synonym: "absent metanephric mesoderm" EXACT []
synonym: "absent nephric mesenchyme" EXACT []
is_a: MP:0010984 ! abnormal metanephric mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:42:31Z

[Term]
id: MP:0011388
name: absent heart
def: "absence of the hollow, muscular organ that maintains the circulation of the blood" [https://orcid.org/0000-0003-4606-0597]
synonym: "absence of heart" EXACT []
synonym: "acardia" EXACT []
synonym: "cardiac agenesis" EXACT []
synonym: "heart agenesis" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:49:27Z

[Term]
id: MP:0011389
name: absent optic disk
def: "absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent optic disc" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "absent optic nerve head" RELATED []
is_a: MP:0008259 ! abnormal optic disk morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T02:55:08Z

[Term]
id: MP:0011390
name: abnormal fetal cardiomyocyte physiology
def: "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0003-3691-0324, PMID:17429040]
synonym: "abnormal cardiomyoblast physiology" EXACT []
synonym: "abnormal foetal cardiomyocyte physiology" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:17:50Z

[Term]
id: MP:0011391
name: abnormal fetal cardiomyocyte apoptosis
def: "change in the timing or the number of fetal cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal fetal cardiomyoblast apoptosis" EXACT []
synonym: "abnormal foetal cardiomyoblast apoptosis" EXACT []
synonym: "abnormal foetal cardiomyocyte apoptosis" EXACT []
is_a: MP:0003221 ! abnormal cardiomyocyte apoptosis
is_a: MP:0011390 ! abnormal fetal cardiomyocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:20:27Z

[Term]
id: MP:0011392
name: increased fetal cardiomyocyte apoptosis
def: "increase in the number of fetal cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased fetal cardiomyoblast apoptosis" EXACT []
synonym: "increased foetal cardiomyoblast apoptosis" EXACT []
synonym: "increased foetal cardiomyocyte apoptosis" EXACT []
is_a: MP:0003222 ! increased cardiomyocyte apoptosis
is_a: MP:0011391 ! abnormal fetal cardiomyocyte apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:22:13Z

[Term]
id: MP:0011393
name: decreased fetal cardiomyocyte apoptosis
def: "reduction in the number of fetal cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased fetal cardiomyoblast apoptosis" EXACT []
synonym: "decreased foetal cardiomyoblast apoptosis" EXACT []
synonym: "decreased foetal cardiomyocyte apoptosis" EXACT []
synonym: "reduced fetal cardiomyoblast apoptosis" EXACT []
synonym: "reduced fetal cardiomyocyte apoptosis" EXACT []
synonym: "reduced foetal cardiomyoblast apoptosis" EXACT []
synonym: "reduced foetal cardiomyocyte apoptosis" EXACT []
is_a: MP:0003223 ! decreased cardiomyocyte apoptosis
is_a: MP:0011391 ! abnormal fetal cardiomyocyte apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:22:13Z

[Term]
id: MP:0011394
name: increased fetal cardiomyocyte proliferation
def: "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cardiomyoblast proliferation" EXACT []
synonym: "increased foetal cardiomyocyte proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0003567 ! abnormal fetal cardiomyocyte proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:25:12Z

[Term]
id: MP:0011395
name: decreased fetal cardiomyocyte proliferation
def: "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cardiomyoblast proliferation" EXACT []
synonym: "decreased foetal cardiomyocyte proliferation" EXACT []
synonym: "reduced fetal cardiomyoblast proliferation" RELATED []
synonym: "reduced fetal cardiomyocyte proliferation" EXACT []
synonym: "reduced foetal cardiomyoblast proliferation" EXACT []
synonym: "reduced foetal cardiomyocyte proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0003567 ! abnormal fetal cardiomyocyte proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:25:39Z

[Term]
id: MP:0011396
name: abnormal sleep behavior
def: "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sleep behaviour" EXACT []
is_a: MP:0021121 ! abnormal rhythmic behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:37:45Z

[Term]
id: MP:0011397
name: endoneurial edema
def: "an excessive accumulation of serous fluid in the interstitial connective tissue of a peripheral nerve" [MGI:llw2]
synonym: "endoneurial oedema" EXACT []
is_a: MP:0001785 ! edema
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:43:25Z

[Term]
id: MP:0011398
name: abnormal endoneurial fluid pressure
def: "measureable anomalies in the fluid of the ganglia and peripheral nerves that lie outside the brain and spinal cord which may interfere with normal nerve physiology" [MGI:llw2]
synonym: "abnormal EFP" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:47:07Z

[Term]
id: MP:0011399
name: increased endoneurial fluid pressure
def: "a measureable increase of serous fluid in the interstitial connective tissue of a peripheral nerve which may interefere with normal nerve physiology" [MGI:llw2]
is_a: MP:0011398 ! abnormal endoneurial fluid pressure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:50:54Z

[Term]
id: MP:0011400
name: lethality, complete penetrance
def: "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
synonym: "complete lethality" EXACT []
is_a: MP:0010769 ! abnormal survival
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T03:57:31Z

[Term]
id: MP:0011401
name: abnormal vascular smooth muscle development
def: "anomaly in the process of forming the nonstriated, involuntary muscle tissue of the blood vessels" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000259 ! abnormal vascular development
is_a: MP:0000733 ! abnormal muscle development
is_a: MP:0005592 ! abnormal vascular smooth muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-21T04:01:54Z

[Term]
id: MP:0011402
name: renal cast
def: "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [https://orcid.org/0000-0002-6490-7723]
synonym: "renal tubular cast" EXACT []
synonym: "renal tubule cast" EXACT []
synonym: "urinary cast" EXACT []
is_a: MP:0003881 ! abnormal nephron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-24T12:54:37Z

[Term]
id: MP:0011403
name: pyelonephritis
def: "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "nephropyelitis" EXACT []
is_a: MP:0001859 ! kidney inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-24T01:05:42Z

[Term]
id: MP:0011404
name: pyelitis
def: "acute inflammation of the pelvis of the kidney, caused by bacterial infection" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney pelvis inflammation" EXACT []
synonym: "renal pelvis inflammation" EXACT []
is_a: MP:0001859 ! kidney inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-24T01:05:42Z

[Term]
id: MP:0011405
name: tubulointerstitial nephritis
def: "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "interstitial nephritis" EXACT []
synonym: "interstitial tubular nephritis" EXACT []
synonym: "tuberulointerstitial nephritis" EXACT []
synonym: "tubulo-interstitial nephritis" EXACT []
is_a: MP:0001859 ! kidney inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-24T01:05:42Z

[Term]
id: MP:0011406
name: abnormal retrotrapezoid nucleus morphology
def: "any structural anomaly in the loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain" [https://orcid.org/0000-0003-4606-0597, PMID:21900566]
is_a: MP:0000846 ! abnormal medulla oblongata morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:13:24Z

[Term]
id: MP:0011407
name: absent nephrogenic zone
def: "absence of the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons;in rodents including mice, this region normally persists for a few days postnatally, although it is lost in humans by 36 weeks of gestation" [PMID:17452023]
is_a: MP:0011334 ! abnormal nephrogenic zone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:16:59Z

[Term]
id: MP:0011408
name: renal tubule hypertrophy
def: "increase in the bulk size of the loop of Henle, the proximal convoluted tubule or the distal convoluted tubule, due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic kidney tubules" EXACT []
synonym: "hypertrophic renal tubules" EXACT []
synonym: "kidney tubule hypertrophy" EXACT []
is_a: MP:0002703 ! abnormal renal tubule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:19:17Z

[Term]
id: MP:0011409
name: increased renal glomerulus basement membrane thickness
def: "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [https://orcid.org/0000-0002-6490-7723]
synonym: "GBM thickening" EXACT []
synonym: "thick renal glomerulus basement membrane" EXACT []
synonym: "thickened renal glomerulus basement membrane" EXACT []
is_a: MP:0011349 ! abnormal renal glomerulus basement membrane thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:22:16Z

[Term]
id: MP:0011410
name: ectopic testis
def: "one or both of the testes located outside the normal pathway of descent into the scrotum" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic testes" EXACT []
synonym: "ectopic testicle" EXACT []
synonym: "ectopic testicles" EXACT []
synonym: "maldescended testes" EXACT []
synonym: "testicular ectopia" EXACT []
synonym: "testis maldescent" EXACT []
is_a: MP:0001146 ! abnormal testis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:24:26Z

[Term]
id: MP:0011411
name: abnormal gonadal ridge morphology
def: "any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal genital ridge morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:26:50Z

[Term]
id: MP:0011412
name: gonadal ridge hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the gonadal ridge, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic genital cord" EXACT []
synonym: "hypoplastic genital ridge" EXACT []
synonym: "hypoplastic gonadal ridge" EXACT []
is_a: MP:0011411 ! abnormal gonadal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-10-31T04:27:29Z

[Term]
id: MP:0011413
name: colorless urine
def: "absence of the usual straw-coloration of the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "colourless urine" EXACT []
is_a: MP:0003619 ! abnormal urine color
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-01T01:18:41Z

[Term]
id: MP:0011414
name: erythruria
def: "passage of red colored urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "red urine" EXACT []
synonym: "reddish colored urine" EXACT []
synonym: "reddish coloured urine" EXACT []
is_a: MP:0003619 ! abnormal urine color
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-01T01:18:41Z

[Term]
id: MP:0011415
name: abnormal aldosterone level
def: "anomaly in the concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [ISBN:0-683-40008-8]
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-07T10:18:19Z

[Term]
id: MP:0011416
name: abnormal testis interstitial tissue morphology
def: "any structural anomaly of the delicate connective tissue stroma that separates the seminiferous tubules and contains clusters of endocrine Leydig cells which secrete testosterone" [ISBN:0-683-40008-8]
synonym: "abnormal Leydig cell region of testis morphology" EXACT [UBERON:0005212]
synonym: "abnormal testis stroma morphology" RELATED []
xref: MA:0002713
is_a: MP:0001146 ! abnormal testis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-07T10:36:07Z

[Term]
id: MP:0011417
name: abnormal renal transport
def: "any anomaly of the directed movement of substances through the kidney" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T10:17:22Z

[Term]
id: MP:0011418
name: leukocyturia
def: "presence of white blood cells in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "leucocyturia" EXACT []
synonym: "leukocytouria" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T02:34:21Z

[Term]
id: MP:0011419
name: erythrocyturia
def: "presence of red blood cells in the urine" [https://orcid.org/0000-0002-6490-7723]
comment: Hematuria (presence of blood in the urine), erythrocyturia (presence of red blood cells in the urine),and erythruria (passage of red urine,) are often used interchangeably.
is_a: MP:0005161 ! hematuria
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:27:10Z

[Term]
id: MP:0011420
name: pyuria
def: "presence of pus in the urine when voided; a sign of inflammation often related to urinary tract infection" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:28:31Z

[Term]
id: MP:0011421
name: cylindruria
def: "presence of renal cylinders or casts in the urine" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:29:01Z

[Term]
id: MP:0011422
name: kidney medulla atrophy
def: "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic kidney medulla" EXACT []
synonym: "atrophic renal medulla" EXACT []
synonym: "kidney medullary atrophy" EXACT []
synonym: "kidney medullary wasting" EXACT []
synonym: "renal medulla atrophy" EXACT []
synonym: "renal medullary atrophy" EXACT []
synonym: "renal medullary wasting" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology
is_a: MP:0004970 ! kidney atrophy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:48:01Z

[Term]
id: MP:0011423
name: kidney cortex atrophy
def: "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic kidney cortex" EXACT []
synonym: "atrophic renal cortex" EXACT []
synonym: "kidney cortical atrophy" EXACT []
synonym: "kidney cortical wasting" EXACT []
synonym: "renal cortex atrophy" EXACT []
synonym: "renal cortical atrophy" EXACT []
synonym: "renal cortical wasting" EXACT []
is_a: MP:0000521 ! abnormal kidney cortex morphology
is_a: MP:0004970 ! kidney atrophy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:48:43Z

[Term]
id: MP:0011424
name: decreased urine uric acid level
def: "abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine urate level" EXACT []
synonym: "hypouricosuria" EXACT []
synonym: "hypouricuria" EXACT []
is_a: MP:0009809 ! abnormal urine uric acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T03:49:43Z

[Term]
id: MP:0011425
name: abnormal kidney interstitium morphology
def: "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal renal interstitium morphology" EXACT []
synonym: "kidney interstitium dysplasia" NARROW []
synonym: "renal interstitium dysplasia" NARROW []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2011-11-08T04:02:12Z

[Term]
id: MP:0011426
name: abnormal ureter smooth muscle morphology
def: "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ureteral smooth muscle morphology" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:10:17Z

[Term]
id: MP:0011427
name: increased mesangial cell number
def: "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic mesangial cells" NARROW []
synonym: "increased deep cell number" EXACT []
synonym: "increased intercapillary cell number" EXACT []
synonym: "increased intraglomerular mesangial cell number" EXACT []
synonym: "increased mesangial cellularity" EXACT []
synonym: "mesangial cell hyperplasia" NARROW []
synonym: "mesangial hypercellularity" EXACT []
is_a: MP:0005327 ! abnormal mesangial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:12:43Z

[Term]
id: MP:0011428
name: decreased mesangial cell number
def: "decreased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased deep cell number" EXACT []
synonym: "decreased intercapillary cell number" EXACT []
synonym: "decreased intraglomerular mesangial cell number" EXACT []
synonym: "decreased mesangial cellularity" EXACT []
synonym: "hypoplastic mesangial cells" NARROW []
synonym: "mesangial cell hypoplasia" NARROW []
synonym: "mesangial hypocellularity" EXACT []
synonym: "reduced mesangial cell number" EXACT []
is_a: MP:0005327 ! abnormal mesangial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:12:43Z

[Term]
id: MP:0011429
name: absent mesangial cell
def: "absence of the phagocytic cells in the capillary tuft of the renal glomerulus, normally interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent deep cell" EXACT []
synonym: "absent intercapillary cell" EXACT []
synonym: "absent intraglomerular mesangial cell" EXACT []
is_a: MP:0011428 ! decreased mesangial cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:12:43Z

[Term]
id: MP:0011430
name: mesangiolysis
def: "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "dissolution of the mesangial matrix" EXACT []
synonym: "mesangial cell degeneration" EXACT []
is_a: MP:0011339 ! abnormal glomerular mesangium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:13:05Z

[Term]
id: MP:0011431
name: increased urine flow rate
def: "increased volume of urine produced in a specified period of time" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevation of urinary volume" EXACT []
synonym: "increase in urine flow" EXACT []
synonym: "increased urinary flow rate" EXACT []
is_a: MP:0001756 ! abnormal urination
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:17:51Z

[Term]
id: MP:0011432
name: decreased urine flow rate
def: "reduced volume of urine produced in a specified period of time" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urinary flow rate" EXACT []
synonym: "reduced urinary flow rate" EXACT []
synonym: "reduced urine flow rate" EXACT []
synonym: "reduction of urinary volume" EXACT []
is_a: MP:0001756 ! abnormal urination
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-08T04:17:51Z

[Term]
id: MP:0011433
name: glomerular capillary congestion
def: "obstruction of the normal flux of blood within the renal glomerular capillaries" [https://orcid.org/0000-0002-6490-7723]
synonym: "glomerular congestion" EXACT []
is_a: MP:0000532 ! kidney vascular congestion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:19:32Z

[Term]
id: MP:0011434
name: abnormal urine magnesium level
def: "any change in the amount of magnesium in the urine" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:22:33Z

[Term]
id: MP:0011435
name: increased urine magnesium level
def: "higher than normal amount of magnesium in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypermagnesiuria" EXACT []
is_a: MP:0011434 ! abnormal urine magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:23:14Z

[Term]
id: MP:0011436
name: decreased urine magnesium level
def: "lower than normal amount of magnesium in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypomagnesiuria" EXACT []
is_a: MP:0011434 ! abnormal urine magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:23:14Z

[Term]
id: MP:0011437
name: glomerulus hemorrhage
def: "bleeding in the renal glomerulus" [https://orcid.org/0000-0002-6490-7723]
synonym: "glomerular bleeding" EXACT []
synonym: "glomerulus haemorrhage" EXACT []
synonym: "intraglomerular haemorrhage" EXACT []
synonym: "intraglomerular hemorrhage" EXACT []
is_a: MP:0000533 ! kidney hemorrhage
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:42:10Z

[Term]
id: MP:0011438
name: absent kidney medulla
def: "failure of the inner portion of the kidney, normally consisting of the renal pyramids, to form" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent renal medulla" EXACT []
is_a: MP:0003014 ! abnormal kidney medulla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:55:35Z

[Term]
id: MP:0011439
name: abnormal kidney cell proliferation
def: "anomaly in the ability of any kidney cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal renal cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:57:24Z

[Term]
id: MP:0011440
name: increased kidney cell proliferation
def: "increase in the expansion rate of any kidney cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased renal cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011439 ! abnormal kidney cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:58:22Z

[Term]
id: MP:0011441
name: decreased kidney cell proliferation
def: "decrease in the expansion rate of any kidney cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased renal cell proliferation" EXACT []
synonym: "reduced kidney cell proliferation" EXACT []
synonym: "reduced renal cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011439 ! abnormal kidney cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T12:58:22Z

[Term]
id: MP:0011442
name: abnormal renal sodium ion transport
def: "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
is_a: MP:0011417 ! abnormal renal transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T01:50:31Z

[Term]
id: MP:0011443
name: abnormal renal water transport
def: "any anomaly in the directed movement of water (H2O) by the kidney" [GO:0003097]
is_a: MP:0011417 ! abnormal renal transport
is_a: MP:0011444 ! abnormal renal water homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T01:52:45Z

[Term]
id: MP:0011444
name: abnormal renal water homeostasis
def: "any anomaly in the kidney processes involved in the maintenance of an internal steady state of water in the body" [GO:0003091]
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T01:54:30Z

[Term]
id: MP:0011445
name: abnormal renal protein reabsorption
def: "any anomaly in the process in which proteins are taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0097017]
synonym: "abnormal renal protein absorption" EXACT []
is_a: MP:0008469 ! abnormal protein level
is_a: MP:0010107 ! abnormal renal reabsorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T02:16:34Z

[Term]
id: MP:0011446
name: abnormal renal albumin reabsorption
def: "any anomaly in the process in which albumin is taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0097018]
synonym: "abnormal renal albumin absorption" EXACT []
is_a: MP:0011445 ! abnormal renal protein reabsorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T02:16:34Z

[Term]
id: MP:0011447
name: abnormal renal glucose reabsorption
def: "any anomaly in the process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0035623]
synonym: "abnormal nephron glucose absorption" EXACT []
synonym: "abnormal renal glucose absorption" EXACT []
is_a: MP:0002078 ! abnormal glucose homeostasis
is_a: MP:0010107 ! abnormal renal reabsorption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T02:16:34Z

[Term]
id: MP:0011448
name: decreased dopaminergic neuron number
def: "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced dopaminergic neuron number" EXACT []
is_a: MP:0003243 ! abnormal dopaminergic neuron morphology
is_a: MP:0008948 ! decreased neuron number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T04:05:37Z

[Term]
id: MP:0011449
name: increased dopaminergic neuron number
def: "greater than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003243 ! abnormal dopaminergic neuron morphology
is_a: MP:0008947 ! increased neuron number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T04:05:37Z

[Term]
id: MP:0011450
name: ectopic dopaminergic neuron
def: "abnormal location of one or more of the neurons that utilize dopamine as a neurotransmitter" [https://orcid.org/0000-0003-4606-0597]
synonym: "ectopic dopaminergic neurons" EXACT []
is_a: MP:0003243 ! abnormal dopaminergic neuron morphology
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T04:05:37Z

[Term]
id: MP:0011451
name: increased susceptibility to dopaminergic neuron neurotoxicity
def: "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased susceptibility to dopamine neuron neurotoxicity" EXACT []
is_a: MP:0008235 ! increased susceptibility to neuronal excitotoxicity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T04:09:40Z

[Term]
id: MP:0011452
name: decreased susceptibility to dopaminergic neuron neurotoxicity
def: "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to dopamine neuron neurotoxicity" EXACT []
synonym: "reduced susceptibility to dopamine neuron neurotoxicity" EXACT []
synonym: "reduced susceptibility to dopaminergic neuron neurotoxicity" EXACT []
is_a: MP:0008236 ! decreased susceptibility to neuronal excitotoxicity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-09T04:10:54Z

[Term]
id: MP:0011453
name: abnormal glomerular capillary endothelium morphology
def: "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009489 ! abnormal blood vessel endothelium morphology
is_a: MP:0011320 ! abnormal glomerular capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-10T02:54:02Z

[Term]
id: MP:0011454
name: abnormal glomerular endothelium fenestra morphology
def: "any structural anomaly of the large plasma membrane-lined circular pores that perforate the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, are not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glomerular endothelial fenestrae" EXACT []
synonym: "abnormal glomerular endothelial fenestrations" EXACT []
synonym: "abnormal glomerular fenestrae" EXACT []
is_a: MP:0011453 ! abnormal glomerular capillary endothelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-10T02:54:02Z

[Term]
id: MP:0011455
name: absent glomerular endothelium fenestra
def: "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent glomerular endothelial fenestrae" EXACT []
synonym: "absent glomerular endothelial fenestrations" EXACT []
synonym: "absent glomerular fenestrae" EXACT []
is_a: MP:0011454 ! abnormal glomerular endothelium fenestra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-10T02:54:02Z

[Term]
id: MP:0011456
name: abnormal ureter ureteric bud development
def: "any anomaly in the development of the elongated stalk of the ureteric bud that contributes to the morphogenesis of the ureter; the ureter ureteric bud is the initial structure that forms the ureter" [GO:0035503]
synonym: "abnormal metanephric duct morphology" EXACT []
is_a: MP:0003672 ! abnormal ureter development
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-10T03:46:11Z

[Term]
id: MP:0011457
name: abnormal metanephric ureteric bud development
def: "any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502]
synonym: "abnormal metanephrogenic diverticulum" EXACT []
is_a: MP:0000527 ! abnormal kidney development
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-10T03:50:18Z

[Term]
id: MP:0011458
name: abnormal urine chloride ion level
def: "any change in the amount of chloride ion in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0012007 ! abnormal chloride level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:19:31Z

[Term]
id: MP:0011459
name: increased urine chloride ion level
def: "abnormally large amounts of chloride ion in the urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased urinary chloride" EXACT []
is_a: MP:0011458 ! abnormal urine chloride ion level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:21:07Z

[Term]
id: MP:0011460
name: decreased urine chloride ion level
def: "abnormally low amounts of chloride ion in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011458 ! abnormal urine chloride ion level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:21:07Z

[Term]
id: MP:0011461
name: abnormal urine bicarbonate level
def: "any change in the amount of bicarbonate in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006272 ! abnormal urine organic anion level
is_a: MP:0031394 ! abnormal bicarbonate level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:30:50Z

[Term]
id: MP:0011462
name: increased urine bicarbonate level
def: "an increased amount of bicarbonate in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "bicarbonaturia" EXACT []
is_a: MP:0011461 ! abnormal urine bicarbonate level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:30:50Z

[Term]
id: MP:0011463
name: decreased urine bicarbonate level
def: "a reduced amount of bicarbonate in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011461 ! abnormal urine bicarbonate level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T11:30:50Z

[Term]
id: MP:0011464
name: bilirubinuria
def: "presence of conjugated bilirubin in the urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "urinary bilirubin" EXACT []
is_a: MP:0002962 ! increased urine protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T01:51:30Z

[Term]
id: MP:0011465
name: abnormal urine urea nitrogen level
def: "any change in the amount of nitrogen in the form of urea in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T03:01:04Z

[Term]
id: MP:0011466
name: increased urine urea nitrogen level
def: "abnormally high amounts of nitrogen in the form of urea in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011465 ! abnormal urine urea nitrogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T03:08:15Z

[Term]
id: MP:0011467
name: decreased urine urea nitrogen level
def: "abnormally low amounts of nitrogen in the form of urea in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011465 ! abnormal urine urea nitrogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-11T03:08:15Z

[Term]
id: MP:0011468
name: abnormal urine amino acid level
def: "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005332 ! abnormal amino acid level
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:00:07Z

[Term]
id: MP:0011469
name: abnormal urine creatinine level
def: "any change in the amount of creatinine in the urine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011468 ! abnormal urine amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:16:50Z

[Term]
id: MP:0011470
name: increased urine creatinine level
def: "an increased amount of creatinine in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011469 ! abnormal urine creatinine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:18:40Z

[Term]
id: MP:0011471
name: decreased urine creatinine level
def: "a reduced amount of creatinine in the urine compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced urine creatinine level" EXACT []
is_a: MP:0011469 ! abnormal urine creatinine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:18:40Z

[Term]
id: MP:0011472
name: abnormal urine glycosaminoglycan level
def: "any change in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal urine GAG level" EXACT []
synonym: "abnormal urine mucopolysaccharide level" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0011475 ! abnormal glycosaminoglycan level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:23:57Z

[Term]
id: MP:0011473
name: increased urine glycosaminoglycan level
def: "greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased urine GAG level" EXACT []
synonym: "increased urine mucopolysaccharide level" EXACT []
synonym: "mucopolysacchariduria" EXACT []
is_a: MP:0011472 ! abnormal urine glycosaminoglycan level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:27:09Z

[Term]
id: MP:0011474
name: decreased urine glycosaminoglycan level
def: "reduced amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased urine GAG level" EXACT []
synonym: "decreased urine mucopolysaccharide level" EXACT []
synonym: "reduced urine GAG level" EXACT []
synonym: "reduced urine glycosaminoglycan level" EXACT []
is_a: MP:0011472 ! abnormal urine glycosaminoglycan level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T10:27:09Z

[Term]
id: MP:0011475
name: abnormal glycosaminoglycan level
def: "any change in the amount of glycosaminoglycan, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal GAG level" EXACT []
synonym: "abnormal mucopolysaccharide level" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T11:11:41Z

[Term]
id: MP:0011476
name: abnormal urine nucleotide level
def: "any change in the urinary level of glycosamines consisting of a nucleobase, a five-carbon sugar moiety (ribose or deoxyribose), and may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:05:08Z

[Term]
id: MP:0011477
name: abnormal urine nucleoside level
def: "any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:05:08Z

[Term]
id: MP:0011478
name: abnormal urine catecholamine level
def: "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0011479 ! abnormal catecholamine level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:26:09Z

[Term]
id: MP:0011479
name: abnormal catecholamine level
def: "any anomaly in the amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:28:32Z

[Term]
id: MP:0011480
name: impaired ureteric peristalsis
def: "any anomaly in the wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, thus propelling urine from the kidney pelvis to the urinary bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired pyeloureteral peristalsis" EXACT []
synonym: "impaired pyeloureteric peristalsis" EXACT []
synonym: "impaired ureteral peristalsis" EXACT []
is_a: MP:0000738 ! impaired muscle contractility
is_a: MP:0003589 ! abnormal ureter physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:44:11Z

[Term]
id: MP:0011481
name: anterior iris synechia
alt_id: MP:0006233
def: "adhesion of the iris to the cornea" [https://orcid.org/0000-0002-6490-7723]
synonym: "anterior synechia" EXACT []
synonym: "anterior synechiae" EXACT []
synonym: "corneal adhesion to iris" EXACT []
synonym: "irido-corneal adhesion" EXACT []
synonym: "irido-corneal synechia" EXACT []
synonym: "irido-corneal synechiae" EXACT []
synonym: "iridocorneal synechia" EXACT []
synonym: "iridocorneal synechiae" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
is_a: MP:0004222 ! iris synechia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:49:12Z

[Term]
id: MP:0011482
name: posterior iris synechia
def: "adhesion of the iris to the capsule of the lens or to the surface of the vitreous body" [https://orcid.org/0000-0002-6490-7723]
synonym: "posterior iris synechiae" EXACT []
synonym: "posterior synechia" EXACT []
is_a: MP:0004222 ! iris synechia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:53:08Z

[Term]
id: MP:0011483
name: renal glomerular synechia
def: "presence of adhesions (synechiae) between the Bowman's capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman's capsule" [https://orcid.org/0000-0002-6490-7723]
synonym: "Bowman's capsule adhesions" EXACT []
synonym: "glomerular synechiae" EXACT []
synonym: "glomerular to capsule adhesions" EXACT []
synonym: "glomerular tuft adhesions" EXACT []
synonym: "glomerular tuft synechia" EXACT []
synonym: "glomerular tuft synechiae" EXACT []
synonym: "glomerulo-capsular synechia" EXACT []
synonym: "glomerulo-capsular synechiae" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-15T02:55:19Z

[Term]
id: MP:0011484
name: abnormal ureter urothelium morphology
def: "any structural anomaly of the epithelial lining of the luminal space of the ureter" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000534 ! abnormal ureter morphology
is_a: MP:0003630 ! abnormal urothelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T12:14:19Z

[Term]
id: MP:0011485
name: abnormal urethra urothelium morphology
def: "any structural anomaly of the epithelial lining of the luminal space of the urethra" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000537 ! abnormal urethra morphology
is_a: MP:0003630 ! abnormal urothelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T12:20:07Z

[Term]
id: MP:0011486
name: ectopic ureter
def: "an abnormally placed opening of the ureter, either into the urinary bladder or at another site in the lower urinary or genital tract; commonly a result of a duplicated renal collecting system, a duplex kidney with two ureters where usually one ureter terminates at the urinary bladder, while the duplicated ureter being ectopic, ends in the vagina, the urethra or the vulval vestibule" [https://orcid.org/0000-0002-6490-7723]
synonym: "ureteral ectopia" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:18:28Z

[Term]
id: MP:0011487
name: abnormal ureteropelvic junction morphology
def: "any structural anomaly of the junction between the ureter and the renal pelvis of the kidney" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal pelviureteric junction morphology" EXACT []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:25:31Z

[Term]
id: MP:0011488
name: abnormal ureterovesical junction morphology
def: "any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal vesicoureteral junction morphology" EXACT []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:26:31Z

[Term]
id: MP:0011489
name: ureteropelvic junction atresia
def: "congenital absence or closure of the connection between the ureter and the renal pelvis" [https://orcid.org/0000-0002-6490-7723]
synonym: "pelviureteric junction atresia" EXACT []
is_a: MP:0011487 ! abnormal ureteropelvic junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:29:17Z

[Term]
id: MP:0011490
name: ureteropelvic junction stenosis
def: "abnormal narrowing or constriction of the junction between the ureter and the renal pelvis" [https://orcid.org/0000-0002-6490-7723]
synonym: "pelviureteric junction stenosis" EXACT []
is_a: MP:0011487 ! abnormal ureteropelvic junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:29:17Z

[Term]
id: MP:0011491
name: ureteropelvic junction obstruction
def: "a partial or total blockage of the flow of urine through the junction of the renal pelvis and the proximal ureter" [https://orcid.org/0000-0002-6490-7723]
synonym: "pelviureteric junction obstruction" EXACT []
is_a: MP:0011487 ! abnormal ureteropelvic junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:29:17Z

[Term]
id: MP:0011492
name: ureterovesical junction obstruction
def: "a partial or total blockage of the valve-like structure found at the site of entry of the ureter into the urinary bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "vesicoureteral junction obstruction" EXACT []
is_a: MP:0011488 ! abnormal ureterovesical junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:31:53Z

[Term]
id: MP:0011493
name: double ureter
def: "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues where the additional ureter may result in a ureterocele, or an ectopic ureter" [http://emedicine.medscape.com/article/378075-overview, https://orcid.org/0000-0002-6490-7723]
synonym: "complete ureteral duplication" EXACT []
synonym: "duplex ureter" EXACT []
synonym: "duplicated ureter" EXACT []
synonym: "duplication of ureter" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T01:43:54Z

[Term]
id: MP:0011494
name: abnormal pigmentation pattern
def: "hair and/or skin coloration shows specific and consistent deviations from an expected display" [MGI:llw2]
is_a: MP:0001186 ! pigmentation phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T02:22:56Z

[Term]
id: MP:0011495
name: abnormal head shape
def: "any anomaly in the characteristic surface outline or contour of a head of an organism" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0000428 ! abnormal craniofacial morphology
is_a: MP:0000432 ! abnormal head morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T02:53:23Z

[Term]
id: MP:0011496
name: abnormal head size
def: "anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC_Prenatal
is_a: MP:0000432 ! abnormal head morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-18T02:56:49Z

[Term]
id: MP:0011497
name: abnormal glomerular capsule visceral layer morphology
def: "any structural anomaly of the inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Bowman's visceral epithelium morphology" EXACT []
synonym: "abnormal visceral epithelium of Bowman's capsule" EXACT []
synonym: "abnormal visceral layer of Bowman's capsule" EXACT []
synonym: "abnormal visceral layer of glomerular capsule" EXACT []
is_a: MP:0002828 ! abnormal renal glomerular capsule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T01:49:15Z

[Term]
id: MP:0011498
name: abnormal glomerular capsule parietal layer morphology
def: "any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Bowman's parietal epithelium morphology" EXACT []
synonym: "abnormal parietal epithelium of Bowman's capsule" EXACT []
synonym: "abnormal parietal layer of Bowman's capsule" EXACT []
synonym: "abnormal parietal layer of glomerular capsule" EXACT []
is_a: MP:0002828 ! abnormal renal glomerular capsule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T01:49:15Z

[Term]
id: MP:0011499
name: abnormal glomerular capsule space morphology
def: "any structural anomaly of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal Bowman's space morphology" EXACT []
synonym: "abnormal glomerular urinary space morphology" EXACT []
is_a: MP:0002828 ! abnormal renal glomerular capsule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T01:49:15Z

[Term]
id: MP:0011500
name: decreased glomerular capsule space
def: "reduced volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased Bowman's space" EXACT []
synonym: "decreased glomerular urinary space" EXACT []
synonym: "reduced Bowman's space" EXACT []
synonym: "reduced glomerular capsule space" EXACT []
synonym: "reduced glomerular urinary space" EXACT []
is_a: MP:0011499 ! abnormal glomerular capsule space morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T01:53:25Z

[Term]
id: MP:0011501
name: increased glomerular capsule space
def: "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [https://orcid.org/0000-0003-3691-0324]
synonym: "Bowman's space dilation" RELATED []
synonym: "dilated Bowman's space" RELATED []
synonym: "enlarged Bowman's space" EXACT []
synonym: "expansion of Bowman's space" EXACT []
synonym: "increased Bowman's space" EXACT []
synonym: "increased glomerular urinary space" EXACT []
is_a: MP:0011499 ! abnormal glomerular capsule space morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T02:05:15Z

[Term]
id: MP:0011502
name: parietal capsular epithelium metaplasia
def: "a metaplastic change or transformation of the single layer of the parietal epithelium of Bowman's capsule from the normal structural appearance of simple squamous epithelium to a cuboidal or low columnar epithelium; also referred to as a prominent parietal epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "cuboidal capsular metaplasia" EXACT []
synonym: "metaplasia of parietal Bowman's capsular epithelium" EXACT []
synonym: "metaplasia of parietal capsular epithelium" EXACT []
synonym: "metaplasia of the parietal layer of Bowman's capsule" EXACT []
synonym: "tubular metaplasia of Bowman's epithelium" EXACT []
is_a: MP:0011498 ! abnormal glomerular capsule parietal layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T02:19:44Z

[Term]
id: MP:0011503
name: distended jejunum
def: "an expansion in the volume of the portion of the small intestine that extends from the duodenum to the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated jejunum" EXACT []
synonym: "jejunal dilation" EXACT []
synonym: "jejunal distension" EXACT []
synonym: "jejunum dilation" EXACT []
synonym: "jejunum distension" EXACT []
synonym: "mega-jejunum" EXACT []
synonym: "swollen jejunum" EXACT []
is_a: MP:0004002 ! abnormal jejunum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-11-22T03:14:15Z

[Term]
id: MP:0011504
name: abnormal limb long bone morphology
def: "any structural anomaly of any of the several elongated bones of the extremities" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002115 ! abnormal limb bone morphology
is_a: MP:0003723 ! abnormal long bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-01T02:34:16Z

[Term]
id: MP:0011505
name: camptomelia
def: "a skeletal dysplasia characterized by the bending of the long bones of the extremities" [ISBN:0-683-40008-8]
synonym: "campomelia" RELATED []
is_a: MP:0011504 ! abnormal limb long bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-01T02:38:20Z

[Term]
id: MP:0011506
name: glomerular crescent
def: "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman's capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman's space, and ultimately compress and destroy the glomerular tuft" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-02T04:16:51Z

[Term]
id: MP:0011507
name: abnormal kidney thrombosis
def: "any anomaly in the formation or presence of one or more thrombi within the blood vessel network of the organ of secretion" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney thrombi" EXACT []
synonym: "renal thrombi" EXACT []
synonym: "renal thrombosis" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-02T04:18:56Z

[Term]
id: MP:0011508
name: abnormal glomerular capillary thrombosis
def: "any anomaly in the formation or presence of one or more thrombi within the renal glomerular capillaries" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011507 ! abnormal kidney thrombosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-02T04:20:02Z

[Term]
id: MP:0011509
name: dilated glomerular capillary
def: "stretched or widened aperture of the luminal space of one or more of the small branching blood vessels in the kidney glomerulus that receive blood from the kidney afferent arterioles" [https://orcid.org/0000-0002-6490-7723]
synonym: "ballooned glomerulus capillary lumen" EXACT []
synonym: "dilated glomerular capillaries" EXACT []
synonym: "glomerular capillary dilation" EXACT []
is_a: MP:0011320 ! abnormal glomerular capillary morphology
is_a: MP:0020326 ! dilated capillary
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-02T04:23:54Z

[Term]
id: MP:0011510
name: biventricular, discordant atrioventricular connection
subset: CvDC_Terms
xref: Fyler:0159
xref: Fyler:159
is_a: MP:0010435 ! abnormal heart atrium and ventricle connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-05T02:14:12Z

[Term]
id: MP:0011511
name: biventricular, ambiguous atrioventricular connection
subset: CvDC_Terms
xref: Fyler:0160
xref: Fyler:160
is_a: MP:0010435 ! abnormal heart atrium and ventricle connection
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-05T02:14:34Z

[Term]
id: MP:0011512
name: mesangial cell interposition
def: "spreading of mesangial cells into the contiguous space between the adjacent glomerular endothelial cells and the glomerular basement membrane (GBM)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005327 ! abnormal mesangial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-05T02:15:55Z

[Term]
id: MP:0011513
name: abnormal vertebral artery morphology
def: "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
xref: MA:0002077
is_a: MP:0011655 ! abnormal systemic artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-08T03:02:10Z

[Term]
id: MP:0011514
name: skin hemorrhage
def: "bleeding into the skin" [https://orcid.org/0000-0002-6490-7723]
subset: IMPC_Prenatal
synonym: "cutaneous bleeding" EXACT []
synonym: "cutaneous haemorrhage" EXACT []
synonym: "cutaneous hemorrhage" EXACT []
synonym: "skin haemorrhage" EXACT []
is_a: MP:0001914 ! hemorrhage
is_a: MP:0005501 ! abnormal skin physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-08T04:07:33Z

[Term]
id: MP:0011515
name: purpura
def: "a smooth, moderately sized hemorrhagic area, typically dark red to reddish purple, resulting from extarvasation of blood into the skin, mucous membrane, or serosal surface; a pupura becomes brown-yellow as it fades and does not blanch on applying pressure" [https://orcid.org/0000-0002-6490-7723]
synonym: "purpurae" EXACT []
is_a: MP:0009931 ! abnormal skin appearance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-08T04:09:08Z

[Term]
id: MP:0011516
name: aspartylglucosaminuria
def: "high urinary levels of aspartylglucosamine, a derivative of aspartic acid; caused by deficient activity of the enzyme N-aspartyl-beta-glucosaminidase (aspartylglucosaminidase) which normally cleaves long sugar chains known as oligosaccharides in the lysosome" [https://orcid.org/0000-0002-6490-7723]
synonym: "AGU" EXACT []
synonym: "aspartylglycosaminuria" EXACT []
is_a: MP:0003311 ! aminoaciduria
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-08T04:14:45Z

[Term]
id: MP:0011517
name: hyperoxaluria
def: "abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones" [https://orcid.org/0000-0002-6490-7723]
synonym: "oxaluria" EXACT []
is_a: MP:0006272 ! abnormal urine organic anion level
is_a: MP:0030613 ! dicarboxylic aciduria
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-08T04:18:31Z

[Term]
id: MP:0011518
name: abnormal cell chemotaxis
def: "any anomaly in the directed movement of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [GO:0060326]
synonym: "abnormal directed cell migration" RELATED []
is_a: MP:0003091 ! abnormal cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T01:53:06Z

[Term]
id: MP:0011519
name: abnormal placenta labyrinth size
def: "anomaly in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011520
name: increased placental labyrinth size
def: "increase in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged placental labyrinth" EXACT []
is_a: MP:0011519 ! abnormal placenta labyrinth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011521
name: decreased placental labyrinth size
def: "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced placental labyrinth size" EXACT []
synonym: "small placental labyrinth" EXACT []
is_a: MP:0011519 ! abnormal placenta labyrinth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011522
name: abnormal placental labyrinth villi morphology
def: "any structural anomaly of the vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation" [PMID:16916377]
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011523
name: thin placenta labyrinth
def: "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011521 ! decreased placental labyrinth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011524
name: thick placenta labyrinth
def: "increase in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011520 ! increased placental labyrinth size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011525
name: abnormal placenta intervillous maternal lacunae morphology
def: "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal maternal placental labyrinth lumen morphology" EXACT []
synonym: "abnormal placenta intervillous maternal space morphology" EXACT []
synonym: "abnormal placenta maternal blood lumen morphology" EXACT []
synonym: "abnormal placenta maternal blood space morphology" EXACT []
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011526
name: abnormal placenta fetal blood space morphology
def: "any structural anomaly of the spaces of the placenta occupied by fetal blood, primarily within the fetal labyrinth villi" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal placenta embryonic blood space morphology" RELATED []
synonym: "abnormal placenta foetal blood space morphology" EXACT []
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011527
name: disorganized placental labyrinth
def: "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised placental labyrinth" EXACT []
is_a: MP:0001716 ! abnormal placenta labyrinth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:30Z

[Term]
id: MP:0011528
name: abnormal placental labyrinth villi branching morphogenesis
def: "any anomaly in the process in which the branches of the fetal placental villi are generated and organized from the trophoblast-derived epithelium" [PMID:16916377]
xref: GO:0060670
is_a: MP:0011522 ! abnormal placental labyrinth villi morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:29:53Z

[Term]
id: MP:0011529
name: increased placenta intervillous maternal lacunae size
def: "increased size of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased maternal placental labyrinth lumen size" EXACT []
synonym: "increased placenta intervillous maternal space size" EXACT []
synonym: "increased placenta maternal blood lumen size" EXACT []
synonym: "increased placenta maternal blood space size" EXACT []
is_a: MP:0011525 ! abnormal placenta intervillous maternal lacunae morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-09T03:57:36Z

[Term]
id: MP:0011530
name: fused radius and ulna
def: "anomaly of the radius and ulna resulting in some portion of or all the two bones being merged together" [https://orcid.org/0000-0003-3691-0324]
synonym: "fusion of radius and ulna" EXACT []
synonym: "radius and ulna fusion" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
is_a: MP:0005108 ! abnormal ulna morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-12T10:36:21Z

[Term]
id: MP:0011531
name: abnormal syncytiotrophoblast morphology
def: "any structural anomaly of the multi-nucleated, terminally differentiated syncytial epithelial layer of the placental villi that forms the major nutrient transport surfaces within the labyrinth layer of the rodent placenta" [ISBN-10:0521851653]
synonym: "abnormal syncytial trophoblast morphology" EXACT []
is_a: MP:0005031 ! abnormal trophoblast layer morphology
is_a: MP:0011522 ! abnormal placental labyrinth villi morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-12T01:15:58Z

[Term]
id: MP:0011532
name: decreased urine major urinary protein level
def: "reduced amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased urine MUP level" EXACT []
is_a: MP:0002963 ! decreased urine protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-13T09:51:24Z

[Term]
id: MP:0011533
name: increased urine major urinary protein level
def: "increased amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased urine MUP level" EXACT []
is_a: MP:0002962 ! increased urine protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-13T09:52:51Z

[Term]
id: MP:0011534
name: granular kidney
def: "a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [https://orcid.org/0000-0002-6490-7723]
synonym: "sclerotic kidney" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-13T12:15:10Z

[Term]
id: MP:0011535
name: increased urination frequency
def: "increased frequency of urination episodes; urination at short frequent intervals occurs without an increase in daily volume of urinary output and may be caused by reduced bladder capacity or urinary tract infection" [https://orcid.org/0000-0002-6490-7723]
comment: Clinicians sometimes mistakenly label increased urinary frequency as polyuria (increased urine output); Though rarely used, pollakisuria (or pollakiuria) is the correct term for increased frequency of urination.
synonym: "decreased urine voiding intervals" EXACT []
synonym: "frequent urination" EXACT []
synonym: "increased number of micturition episodes" EXACT []
synonym: "increased urinary frequency" EXACT []
synonym: "pollachiuria" EXACT []
synonym: "pollacisuria" EXACT []
synonym: "pollakisuria" EXACT []
synonym: "pollakiuria" EXACT []
is_a: MP:0001761 ! abnormal urination pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-13T12:18:30Z

[Term]
id: MP:0011536
name: decreased urination frequency
def: "decreased frequency of urination episodes; urination at long intervals occurs without an decrease in daily volume of urinary output" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased number of micturition episodes" EXACT []
synonym: "increased urine voiding intervals" EXACT []
synonym: "infrequent urination" EXACT []
synonym: "reduced urinary frequency" EXACT []
is_a: MP:0001761 ! abnormal urination pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-13T12:18:30Z

[Term]
id: MP:0011537
name: uraturia
def: "passage of an increased amount of any salt or ester of uric acid (urate) in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine urate level" EXACT []
is_a: MP:0009810 ! increased urine uric acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T09:54:36Z

[Term]
id: MP:0011538
name: abnormal urine hormone level
def: "any change in the urine amount of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003953 ! abnormal hormone level
is_a: MP:0006315 ! abnormal urine protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:14Z

[Term]
id: MP:0011539
name: abnormal urine aldosterone level
def: "any change in the urine amount of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011415 ! abnormal aldosterone level
is_a: MP:0011538 ! abnormal urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011540
name: increased urine aldosterone level
def: "an increased amount of aldosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011539 ! abnormal urine aldosterone level
is_a: MP:0014458 ! increased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011541
name: decreased urine aldosterone level
def: "a reduced amount of aldosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urine aldosterone level" EXACT []
is_a: MP:0011539 ! abnormal urine aldosterone level
is_a: MP:0014459 ! decreased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011542
name: abnormal urine antidiuretic hormone level
def: "any change in the urine amount of the polypeptide hormone secreted by the posterior lobe of the pituitary gland (neurohypophysis) that increases mean arterial pressure by promoting vasoconstriction and reduces excretion of urine by increasing the reabsorption of water by the kidney tubules" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urine ADH level" EXACT []
synonym: "abnormal urine arginine vasopressin level" EXACT []
synonym: "abnormal urine argipressin level" EXACT []
synonym: "abnormal urine AVP level" EXACT []
synonym: "abnormal urine vasopressin level" EXACT []
is_a: MP:0011538 ! abnormal urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011543
name: increased urine antidiuretic hormone level
def: "an increased amount of antidiuretic hormone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine ADH level" EXACT []
synonym: "increased urine arginine vasopressin level" EXACT []
synonym: "increased urine argipressin level" EXACT []
synonym: "increased urine AVP level" EXACT []
synonym: "increased urine vasopressin level" EXACT []
is_a: MP:0011542 ! abnormal urine antidiuretic hormone level
is_a: MP:0014458 ! increased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011544
name: decreased urine antidiuretic hormone level
def: "a reduced amount of antidiuretic hormone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine ADH level" EXACT []
synonym: "decreased urine arginine vasopressin level" EXACT []
synonym: "decreased urine argipressin level" EXACT []
synonym: "decreased urine AVP level" EXACT []
synonym: "decreased urine vasopressin level" EXACT []
synonym: "reduced urine ADH level" EXACT []
synonym: "reduced urine arginine vasopressin level" EXACT []
synonym: "reduced urine argipressin level" EXACT []
synonym: "reduced urine AVP level" EXACT []
synonym: "reduced urine vasopressin level" EXACT []
is_a: MP:0011542 ! abnormal urine antidiuretic hormone level
is_a: MP:0014459 ! decreased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011545
name: abnormal urine progesterone level
def: "any change in the urine amount of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urine corpus luteum hormone level" EXACT []
synonym: "abnormal urine luteohormone level" EXACT []
synonym: "abnormal urine pregnancy hormone level" EXACT []
synonym: "abnormal urine progestational hormone level" EXACT []
is_a: MP:0011384 ! abnormal progesterone level
is_a: MP:0011538 ! abnormal urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011546
name: increased urine progesterone level
def: "an increased amount of progesterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine corpus luteum hormone level" EXACT []
synonym: "increased urine luteohormone level" EXACT []
synonym: "increased urine pregnancy hormone level" EXACT []
synonym: "increased urine progestational hormone level" EXACT []
is_a: MP:0011545 ! abnormal urine progesterone level
is_a: MP:0014458 ! increased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011547
name: decreased urine progesterone level
def: "a reduced amount of progesterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine corpus luteum hormone level" EXACT []
synonym: "decreased urine luteohormone level" EXACT []
synonym: "decreased urine pregnancy hormone level" EXACT []
synonym: "decreased urine progestational hormone level" EXACT []
synonym: "reduced urine corpus luteum hormone level" EXACT []
synonym: "reduced urine luteohormone level" EXACT []
synonym: "reduced urine pregnancy hormone level" EXACT []
synonym: "reduced urine progestational hormone level" EXACT []
is_a: MP:0011545 ! abnormal urine progesterone level
is_a: MP:0014459 ! decreased urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011548
name: abnormal urine corticosterone level
def: "any change in the urine amount of the corticosteroid produced in the adrenal cortex that induces glycogen deposition and regulates sodium conservation and potassium secretion" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003963 ! abnormal corticosterone level
is_a: MP:0011538 ! abnormal urine hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011549
name: increased urine corticosterone level
def: "an increased amount of corticosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011548 ! abnormal urine corticosterone level
is_a: MP:0014458 ! increased urine hormone level
is_a: MP:0014460 ! increased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011550
name: decreased urine corticosterone level
def: "a reduced amount of corticosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011548 ! abnormal urine corticosterone level
is_a: MP:0014459 ! decreased urine hormone level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:03:29Z

[Term]
id: MP:0011551
name: variegated eye pigmentation pattern
def: "an irregular and random patchwork of two or more colors in the eye" [MGI:llw2]
is_a: MP:0001324 ! abnormal eye pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-16T04:10:18Z

[Term]
id: MP:0011552
name: abnormal urine deoxycorticosterone level
def: "any change in the urine amount of the steroid hormone secreted by the adrenal cortex, related to corticosterone and involved in regulating water and electrolyte balance" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urine 11-deoxycorticosterone level" EXACT []
synonym: "abnormal urine 21-hydroxyprogesterone level" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:01:30Z

[Term]
id: MP:0011553
name: increased urine deoxycorticosterone level
def: "an increased amount of deoxycorticosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine 11-deoxycorticosterone level" EXACT []
synonym: "increased urine 21-hydroxyprogesterone level" EXACT []
is_a: MP:0011552 ! abnormal urine deoxycorticosterone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:01:30Z

[Term]
id: MP:0011554
name: decreased urine deoxycorticosterone level
def: "a reduced amount of deoxycorticosterone in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine 11-deoxycorticosterone level" EXACT []
synonym: "decreased urine 21-hydroxyprogesterone level" EXACT []
synonym: "reduced urine 11-deoxycorticosterone level" EXACT []
synonym: "reduced urine 21-hydroxyprogesterone level" EXACT []
is_a: MP:0011552 ! abnormal urine deoxycorticosterone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:01:30Z

[Term]
id: MP:0011555
name: increased urine microglobulin level
def: "greater than the normal amount of any globulin (or any fragment of a globulin) of low molecular weight in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "microglobulinuria" EXACT []
is_a: MP:0002962 ! increased urine protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:05:15Z

[Term]
id: MP:0011556
name: increased urine beta2-microglobulin level
def: "greater than the normal amount of beta2-microglobulin in the urine; may indicate renal tubule disease, drug-induced renal toxicity, heavy metal-induced renal disease, lymphomas, leukemia, or myeloma" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011555 ! increased urine microglobulin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:05:29Z

[Term]
id: MP:0011557
name: increased susceptibility to induced choroid neovascularization
def: "increased rate or amount of new growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-0431-8641]
synonym: "decreased resistance to induced choroidal neovascularization" EXACT []
is_a: MP:0005546 ! choroidal neovascularization
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:12:10Z

[Term]
id: MP:0011558
name: abnormal urine insulin level
def: "any change in the amount of insulin in the urine" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:15:31Z

[Term]
id: MP:0011559
name: increased urine insulin level
def: "a greater amount of insulin in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011558 ! abnormal urine insulin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:15:31Z

[Term]
id: MP:0011560
name: decreased urine insulin level
def: "a reduced amount of insulin in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urine insulin level" EXACT []
is_a: MP:0011558 ! abnormal urine insulin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:15:31Z

[Term]
id: MP:0011561
name: renal glomerulus lipidosis
def: "presence of lipid deposits and/or lipid-laden foam cells in the renal glomerular tufts" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney glomerular lipidosis" EXACT []
synonym: "kidney glomerulus lipidosis" EXACT []
synonym: "renal glomerular lipidosis" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:19:35Z

[Term]
id: MP:0011562
name: abnormal urine prostaglandin level
def: "any change in the urinary amount of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:21:52Z

[Term]
id: MP:0011563
name: increased urine prostaglandin level
def: "a greater amount of any prostaglandin in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperprostaglandinuria" EXACT []
is_a: MP:0011562 ! abnormal urine prostaglandin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:21:52Z

[Term]
id: MP:0011564
name: decreased urine prostaglandin level
def: "a reduced amount of any prostaglandin in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urine prostaglandin level" EXACT []
is_a: MP:0011562 ! abnormal urine prostaglandin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:21:52Z

[Term]
id: MP:0011565
name: kidney papillary hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the kidney papilla, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic kidney papilla" EXACT []
synonym: "renal papillary hypoplasia" EXACT []
is_a: MP:0004193 ! abnormal kidney papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2011-12-20T04:25:40Z

[Term]
id: MP:0011566
name: abnormal complement protein level
def: "deviation from the normal levels, or accumulation of the proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002471 ! abnormal complement pathway
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-12T01:39:01Z

[Term]
id: MP:0011567
name: increased renal glomerulus lobularity
def: "distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance" [https://orcid.org/0000-0002-6490-7723]
synonym: "accentuated glomerular lobulation" EXACT []
synonym: "hyperlobular glomeruli" EXACT []
synonym: "hypersegmented glomeruli" EXACT []
synonym: "increased renal glomerular lobularity" EXACT []
synonym: "lobulated glomeruli" EXACT []
synonym: "lobulation of the glomerular tuft" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-12T01:43:44Z

[Term]
id: MP:0011568
name: decreased foot pigmentation
def: "visually detectable dilution of pigment present on the foot surface" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005408 ! hypopigmentation
is_a: MP:0009379 ! abnormal foot pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-12T01:47:07Z

[Term]
id: MP:0011569
name: abnormal azygos vein morphology
def: "any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vena azygos morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-12T02:14:19Z

[Term]
id: MP:0011570
name: esophageal achalasia
def: "failure of the normal relaxation of the lower esophageal sphincter associated with the uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction" [ISBN:0-683-40008-8]
synonym: "achalasia of the cardia" EXACT []
synonym: "cardiospasm" NARROW []
is_a: MP:0004108 ! abnormal esophageal peristalsis
is_a: MP:0010154 ! abnormal gastroesophageal sphincter physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-18T10:35:52Z

[Term]
id: MP:0011571
name: enlarged inferior vena cava valve
def: "increased size of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8]
subset: CvDC_Terms
synonym: "enlarged Eustachian valve" EXACT []
synonym: "enlarged sylvian valve" EXACT []
synonym: "increased Eustachian valve size" EXACT []
synonym: "increased inferior vena cava valve size" EXACT []
synonym: "increased sylvian valve size" EXACT []
xref: Fyler:2852
is_a: MP:0010490 ! abnormal inferior vena cava valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-24T02:49:24Z

[Term]
id: MP:0011572
name: abnormal aorta bulb morphology
def: "any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [https://orcid.org/0000-0003-3691-0324, PMID:10722531]
synonym: "abnormal aortic bulb morphology" EXACT []
synonym: "abnormal aortic root morphology" EXACT []
synonym: "abnormal bulb of aorta morphology" EXACT []
synonym: "abnormal bulb of ascending aorta morphology" EXACT []
synonym: "abnormal root of aorta morphology" EXACT []
synonym: "abnormal supraaortic valve area morphology" EXACT []
xref: FMA:3740
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T10:18:56Z

[Term]
id: MP:0011573
name: abnormal sinotubular junction morphology
def: "any structural anomaly of the point in the ascending aorta where the aortic sinuses end and the aorta becomes a tubular structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal sinotubular ridge morphology" EXACT []
is_a: MP:0009867 ! abnormal ascending aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T10:24:17Z

[Term]
id: MP:0011574
name: dilated sinotubular junction
def: "the luminal space of the sinotubular junction is increased in diameter or area" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated sinotubular junctions" EXACT []
synonym: "dilated sinotubular ridge" EXACT []
synonym: "dilated sinotubular ridges" EXACT []
synonym: "sinotubular junction dilation" EXACT []
synonym: "sinotubular ridge dilation" EXACT []
is_a: MP:0010470 ! dilated ascending aorta
is_a: MP:0011573 ! abnormal sinotubular junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T10:27:10Z

[Term]
id: MP:0011575
name: dilated aorta bulb
def: "the luminal space of the aorta bulb is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "aorta bulb dilation" EXACT []
synonym: "aortic bulb dilation" EXACT []
synonym: "aortic root dilation" EXACT []
synonym: "dilated aortic bulb" EXACT []
synonym: "dilated aortic root" EXACT []
synonym: "dilated bulb of aorta" EXACT []
synonym: "dilated root of aorta" EXACT []
synonym: "dilation of supraaortic valve area" EXACT []
is_a: MP:0010470 ! dilated ascending aorta
is_a: MP:0011572 ! abnormal aorta bulb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T11:38:04Z

[Term]
id: MP:0011576
name: absent cervical atlas
def: "absence of the first (topmost, C1) cervical vertebra which supports the globe of the head" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent C1 vertebra" EXACT []
is_a: MP:0004607 ! abnormal cervical atlas morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:01:53Z

[Term]
id: MP:0011577
name: abnormal lipoprotein lipase activity
def: "anomaly in the ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004806]
synonym: "abnormal clearing factor lipase activity" EXACT []
synonym: "abnormal diacylglycerol hydrolase activity" EXACT []
synonym: "abnormal diacylglycerol lipase activity" EXACT []
synonym: "abnormal diglyceride lipase activity" EXACT []
synonym: "abnormal lipemia-clearing factor" EXACT []
synonym: "abnormal postheparin esterase activity" EXACT []
synonym: "abnormal postheparin lipase activity" EXACT []
synonym: "abnormal triacylglycero-protein acylhydrolase activity" EXACT []
is_a: MP:0011580 ! abnormal triglyceride lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011578
name: increased lipoprotein lipase activity
def: "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
synonym: "increased clearing factor lipase activity" EXACT []
synonym: "increased diacylglycerol hydrolase activity" EXACT []
synonym: "increased diacylglycerol lipase activity" EXACT []
synonym: "increased diglyceride lipase activity" EXACT []
synonym: "increased lipemia-clearing factor" EXACT []
synonym: "increased postheparin esterase activity" EXACT []
synonym: "increased postheparin lipase activity" EXACT []
synonym: "increased triacylglycero-protein acylhydrolase activity" EXACT []
is_a: MP:0011577 ! abnormal lipoprotein lipase activity
is_a: MP:0011581 ! increased triglyceride lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011579
name: decreased lipoprotein lipase activity
def: "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
synonym: "decreased clearing factor lipase activity" EXACT []
synonym: "decreased diacylglycerol hydrolase activity" EXACT []
synonym: "decreased diacylglycerol lipase activity" EXACT []
synonym: "decreased diglyceride lipase activity" EXACT []
synonym: "decreased lipemia-clearing factor" EXACT []
synonym: "decreased postheparin esterase activity" EXACT []
synonym: "decreased postheparin lipase activity" EXACT []
synonym: "decreased triacylglycero-protein acylhydrolase activity" EXACT []
is_a: MP:0011577 ! abnormal lipoprotein lipase activity
is_a: MP:0011582 ! decreased triglyceride lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011580
name: abnormal triglyceride lipase activity
def: "anomaly in the ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
synonym: "abnormal butyrinase activity" EXACT []
synonym: "abnormal cacordase activity" EXACT []
synonym: "abnormal capalase L" EXACT []
synonym: "abnormal glycerol ester hydrolase activity" EXACT []
synonym: "abnormal glycerol-ester hydrolase activity" EXACT []
synonym: "abnormal heparin releasable hepatic lipase" EXACT []
synonym: "abnormal hepatic lipase" EXACT []
synonym: "abnormal hepatic monoacylglycerol acyltransferase" EXACT []
synonym: "abnormal lipazin" EXACT []
synonym: "abnormal liver lipase" EXACT []
synonym: "abnormal post-heparin plasma protamine-resistant lipase" EXACT []
synonym: "abnormal PPL" EXACT []
synonym: "abnormal salt-resistant post-heparin lipase" EXACT []
synonym: "abnormal triacetinase activity" EXACT []
synonym: "abnormal triacylglycerol acylhydrolase activity" EXACT []
synonym: "abnormal triacylglycerol ester hydrolase activity" EXACT []
synonym: "abnormal triacylglycerol lipase activity" EXACT []
synonym: "abnormal tributyrase activity" EXACT []
synonym: "abnormal tributyrin esterase activity" EXACT []
synonym: "abnormal tributyrinase activity" EXACT []
synonym: "abnormal triglyceridase activity" EXACT []
synonym: "abnormal triglyceride hydrolase activity" EXACT []
synonym: "abnormal triolein hydrolase activity" EXACT []
synonym: "abnormal tween hydrolase activity" EXACT []
synonym: "abnormal tween-hydrolyzing esterase activity" EXACT []
synonym: "abnormal tweenase activity" EXACT []
synonym: "abnormal tweenesterase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011581
name: increased triglyceride lipase activity
def: "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
synonym: "increased butyrinase activity" EXACT []
synonym: "increased cacordase activity" EXACT []
synonym: "increased capalase L" EXACT []
synonym: "increased glycerol ester hydrolase activity" EXACT []
synonym: "increased glycerol-ester hydrolase activity" EXACT []
synonym: "increased heparin releasable hepatic lipase" EXACT []
synonym: "increased hepatic lipase" EXACT []
synonym: "increased hepatic monoacylglycerol acyltransferase" EXACT []
synonym: "increased lipazin" EXACT []
synonym: "increased liver lipase" EXACT []
synonym: "increased post-heparin plasma protamine-resistant lipase" EXACT []
synonym: "increased PPL" EXACT []
synonym: "increased salt-resistant post-heparin lipase" EXACT []
synonym: "increased triacetinase activity" EXACT []
synonym: "increased triacylglycerol acylhydrolase activity" EXACT []
synonym: "increased triacylglycerol ester hydrolase activity" EXACT []
synonym: "increased triacylglycerol lipase activity" EXACT []
synonym: "increased tributyrase activity" EXACT []
synonym: "increased tributyrin esterase activity" EXACT []
synonym: "increased tributyrinase activity" EXACT []
synonym: "increased triglyceridase activity" EXACT []
synonym: "increased triglyceride hydrolase activity" EXACT []
synonym: "increased triolein hydrolase activity" EXACT []
synonym: "increased tween hydrolase activity" EXACT []
synonym: "increased tween-hydrolyzing esterase activity" EXACT []
synonym: "increased tweenase activity" EXACT []
synonym: "increased tweenesterase activity" EXACT []
is_a: MP:0011580 ! abnormal triglyceride lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011582
name: decreased triglyceride lipase activity
def: "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
synonym: "decreased butyrinase activity" EXACT []
synonym: "decreased cacordase activity" EXACT []
synonym: "decreased capalase L" EXACT []
synonym: "decreased glycerol ester hydrolase activity" EXACT []
synonym: "decreased glycerol-ester hydrolase activity" EXACT []
synonym: "decreased heparin releasable hepatic lipase" EXACT []
synonym: "decreased hepatic lipase" EXACT []
synonym: "decreased hepatic monoacylglycerol acyltransferase" EXACT []
synonym: "decreased lipazin" EXACT []
synonym: "decreased liver lipase" EXACT []
synonym: "decreased post-heparin plasma protamine-resistant lipase" EXACT []
synonym: "decreased PPL" EXACT []
synonym: "decreased salt-resistant post-heparin lipase" EXACT []
synonym: "decreased triacetinase activity" EXACT []
synonym: "decreased triacylglycerol acylhydrolase activity" EXACT []
synonym: "decreased triacylglycerol ester hydrolase activity" EXACT []
synonym: "decreased triacylglycerol lipase activity" EXACT []
synonym: "decreased tributyrase activity" EXACT []
synonym: "decreased tributyrin esterase activity" EXACT []
synonym: "decreased tributyrinase activity" EXACT []
synonym: "decreased triglyceridase activity" EXACT []
synonym: "decreased triglyceride hydrolase activity" EXACT []
synonym: "decreased triolein hydrolase activity" EXACT []
synonym: "decreased tween hydrolase activity" EXACT []
synonym: "decreased tween-hydrolyzing esterase activity" EXACT []
synonym: "decreased tweenase activity" EXACT []
synonym: "decreased tweenesterase activity" EXACT []
is_a: MP:0011580 ! abnormal triglyceride lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:27:41Z

[Term]
id: MP:0011583
name: abnormal alkaline phosphatase activity
def: "anomaly in the ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
synonym: "abnormal alkaline phenyl phosphatase activity" EXACT []
synonym: "abnormal alkaline phosphohydrolase activity" EXACT []
synonym: "abnormal alkaline phosphomonoesterase activity" EXACT []
synonym: "abnormal glycerophosphatase activity" EXACT []
synonym: "abnormal orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "abnormal phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "abnormal phosphomonoesterase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:50:01Z

[Term]
id: MP:0011584
name: increased alkaline phosphatase activity
def: "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
synonym: "increased alkaline phenyl phosphatase activity" EXACT []
synonym: "increased alkaline phosphohydrolase activity" EXACT []
synonym: "increased alkaline phosphomonoesterase activity" EXACT []
synonym: "increased glycerophosphatase activity" EXACT []
synonym: "increased orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "increased phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "increased phosphomonoesterase activity" EXACT []
is_a: MP:0011583 ! abnormal alkaline phosphatase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:51:35Z

[Term]
id: MP:0011585
name: decreased alkaline phosphatase activity
def: "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
synonym: "decreased alkaline phenyl phosphatase activity" EXACT []
synonym: "decreased alkaline phosphohydrolase activity" EXACT []
synonym: "decreased alkaline phosphomonoesterase activity" EXACT []
synonym: "decreased glycerophosphatase activity" EXACT []
synonym: "decreased orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "decreased phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT []
synonym: "decreased phosphomonoesterase activity" EXACT []
is_a: MP:0011583 ! abnormal alkaline phosphatase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T03:51:35Z

[Term]
id: MP:0011586
name: abnormal ornithine carbamoyltransferase activity
def: "anomaly in the ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline" [GO:0004585]
synonym: "abnormal carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT []
synonym: "abnormal carbamylphosphate-ornithine transcarbamylase activity" EXACT []
synonym: "abnormal citrulline phosphorylase activity" EXACT []
synonym: "abnormal L-ornithine carbamoyltransferase activity" EXACT []
synonym: "abnormal L-ornithine carbamyltransferase activity" EXACT []
synonym: "abnormal L-ornithine transcarbamylase activity" EXACT []
synonym: "abnormal ornithine carbamyltransferase activity" EXACT []
synonym: "abnormal ornithine transcarbamylase activity" EXACT []
synonym: "abnormal OTC activity" EXACT []
synonym: "abnormal OTCase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T04:00:56Z

[Term]
id: MP:0011587
name: increased ornithine carbamoyltransferase activity
def: "greater ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline" [GO:0004585]
synonym: "increased carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT []
synonym: "increased carbamylphosphate-ornithine transcarbamylase activity" EXACT []
synonym: "increased citrulline phosphorylase activity" EXACT []
synonym: "increased L-ornithine carbamoyltransferase activity" EXACT []
synonym: "increased L-ornithine carbamyltransferase activity" EXACT []
synonym: "increased L-ornithine transcarbamylase activity" EXACT []
synonym: "increased ornithine carbamyltransferase activity" EXACT []
synonym: "increased ornithine transcarbamylase activity" EXACT []
synonym: "increased OTC activity" EXACT []
synonym: "increased OTCase activity" EXACT []
is_a: MP:0011586 ! abnormal ornithine carbamoyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T04:00:56Z

[Term]
id: MP:0011588
name: decreased ornithine carbamoyltransferase activity
def: "reduced ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline" [GO:0004585]
synonym: "decreased carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT []
synonym: "decreased carbamylphosphate-ornithine transcarbamylase activity" EXACT []
synonym: "decreased citrulline phosphorylase activity" EXACT []
synonym: "decreased L-ornithine carbamoyltransferase activity" EXACT []
synonym: "decreased L-ornithine carbamyltransferase activity" EXACT []
synonym: "decreased L-ornithine transcarbamylase activity" EXACT []
synonym: "decreased ornithine carbamyltransferase activity" EXACT []
synonym: "decreased ornithine transcarbamylase activity" EXACT []
synonym: "decreased OTC activity" EXACT []
synonym: "decreased OTCase activity" EXACT []
is_a: MP:0011586 ! abnormal ornithine carbamoyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-25T04:00:56Z

[Term]
id: MP:0011589
name: abnormal hormone-sensitive lipase activity
def: "anomaly in the ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate" [GO:0033878]
synonym: "abnormal diacylglycerol acylhydrolase activity" EXACT []
synonym: "abnormal HSL" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011590
name: increased hormone-sensitive lipase activity
def: "greater ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate" [GO:0033878]
synonym: "increased diacylglycerol acylhydrolase activity" EXACT []
synonym: "increased HSL" EXACT []
is_a: MP:0011589 ! abnormal hormone-sensitive lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011591
name: decreased hormone-sensitive lipase activity
def: "reduced ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate" [GO:0033878]
synonym: "decreased diacylglycerol acylhydrolase activity" EXACT []
synonym: "decreased HSL" EXACT []
is_a: MP:0011589 ! abnormal hormone-sensitive lipase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011592
name: abnormal catalase activity
def: "anomaly in the ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
synonym: "abnormal bacterial catalase-peroxidase activity" EXACT []
synonym: "abnormal caperase activity" EXACT []
synonym: "abnormal CAT" EXACT []
synonym: "abnormal catalase reaction" EXACT []
synonym: "abnormal catalase-peroxidase activity" EXACT []
synonym: "abnormal equilase activity" EXACT []
synonym: "abnormal haem catalase activity" EXACT []
synonym: "abnormal heme catalase activity" EXACT []
synonym: "abnormal hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "abnormal manganese catalase activity" EXACT []
synonym: "abnormal optidase activity" EXACT []
is_a: MP:0012579 ! abnormal peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011593
name: increased catalase activity
def: "greater ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
synonym: "increased bacterial catalase-peroxidase activity" EXACT []
synonym: "increased caperase activity" EXACT []
synonym: "increased CAT" EXACT []
synonym: "increased catalase reaction" EXACT []
synonym: "increased catalase-peroxidase activity" EXACT []
synonym: "increased equilase activity" EXACT []
synonym: "increased haem catalase activity" EXACT []
synonym: "increased heme catalase activity" EXACT []
synonym: "increased hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "increased manganese catalase activity" EXACT []
synonym: "increased optidase activity" EXACT []
is_a: MP:0011592 ! abnormal catalase activity
is_a: MP:0012582 ! increased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011594
name: decreased catalase activity
def: "reduced ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
synonym: "decreased bacterial catalase-peroxidase activity" EXACT []
synonym: "decreased caperase activity" EXACT []
synonym: "decreased CAT" EXACT []
synonym: "decreased catalase reaction" EXACT []
synonym: "decreased catalase-peroxidase activity" EXACT []
synonym: "decreased equilase activity" EXACT []
synonym: "decreased haem catalase activity" EXACT []
synonym: "decreased heme catalase activity" EXACT []
synonym: "decreased hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "decreased manganese catalase activity" EXACT []
synonym: "decreased optidase activity" EXACT []
is_a: MP:0011592 ! abnormal catalase activity
is_a: MP:0012580 ! decreased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011595
name: abnormal purine-nucleoside phosphorylase activity
def: "anomaly in the ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate" [GO:0004731]
synonym: "abnormal inosine phosphorylase activity" EXACT []
synonym: "abnormal inosine-guanosine phosphorylase activity" EXACT []
synonym: "abnormal PNPase activity" EXACT []
synonym: "abnormal PUNPI" EXACT []
synonym: "abnormal PUNPII" EXACT []
synonym: "abnormal purine deoxynucleoside phosphorylase activity" EXACT []
synonym: "abnormal purine deoxyribonucleoside phosphorylase activity" EXACT []
synonym: "abnormal purine nucleoside phosphorylase activity" EXACT []
synonym: "abnormal purine ribonucleoside phosphorylase activity" EXACT []
synonym: "abnormal purine-nucleoside:phosphate ribosyltransferase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011596
name: increased purine-nucleoside phosphorylase activity
def: "greater ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate" [GO:0004731]
synonym: "increased inosine phosphorylase activity" EXACT []
synonym: "increased inosine-guanosine phosphorylase activity" EXACT []
synonym: "increased PNPase activity" EXACT []
synonym: "increased PUNPI" EXACT []
synonym: "increased PUNPII" EXACT []
synonym: "increased purine deoxynucleoside phosphorylase activity" EXACT []
synonym: "increased purine deoxyribonucleoside phosphorylase activity" EXACT []
synonym: "increased purine nucleoside phosphorylase activity" EXACT []
synonym: "increased purine ribonucleoside phosphorylase activity" EXACT []
synonym: "increased purine-nucleoside:phosphate ribosyltransferase activity" EXACT []
is_a: MP:0011595 ! abnormal purine-nucleoside phosphorylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011597
name: decreased purine-nucleoside phosphorylase activity
def: "reduced ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate" [GO:0004607]
synonym: "decreased inosine phosphorylase activity" EXACT []
synonym: "decreased inosine-guanosine phosphorylase activity" EXACT []
synonym: "decreased PNPase activity" EXACT []
synonym: "decreased PUNPI" EXACT []
synonym: "decreased PUNPII" EXACT []
synonym: "decreased purine deoxynucleoside phosphorylase activity" EXACT []
synonym: "decreased purine deoxyribonucleoside phosphorylase activity" EXACT []
synonym: "decreased purine nucleoside phosphorylase activity" EXACT []
synonym: "decreased purine ribonucleoside phosphorylase activity" EXACT []
synonym: "decreased purine-nucleoside:phosphate ribosyltransferase activity" EXACT []
is_a: MP:0011595 ! abnormal purine-nucleoside phosphorylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011598
name: abnormal phosphatidylcholine-sterol O-acyltransferase activity
def: "anomaly in the ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine" [GO:0004731]
synonym: "abnormal LCAT (lecithin-cholesterol acyltransferase)" EXACT []
synonym: "abnormal LCAT activity" EXACT []
synonym: "abnormal lecithin--cholesterol acyltransferase activity" EXACT []
synonym: "abnormal lecithin-cholesterol acyltransferase activity" EXACT []
synonym: "abnormal lecithin:cholesterol acyltransferase activity" EXACT []
synonym: "abnormal phosphatidylcholine:sterol O-acyltransferase activity" EXACT []
synonym: "abnormal phospholipid--cholesterol acyltransferase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011599
name: increased phosphatidylcholine-sterol O-acyltransferase activity
def: "greater ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine" [GO:0004731]
synonym: "increased LCAT (lecithin-cholesterol acyltransferase)" EXACT []
synonym: "increased LCAT activity" EXACT []
synonym: "increased lecithin--cholesterol acyltransferase activity" EXACT []
synonym: "increased lecithin-cholesterol acyltransferase activity" EXACT []
synonym: "increased lecithin:cholesterol acyltransferase activity" EXACT []
synonym: "increased phosphatidylcholine:sterol O-acyltransferase activity" EXACT []
synonym: "increased phospholipid--cholesterol acyltransferase activity" EXACT []
is_a: MP:0011598 ! abnormal phosphatidylcholine-sterol O-acyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011600
name: decreased phosphatidylcholine-sterol O-acyltransferase activity
def: "reduced ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine" [GO:0004731]
synonym: "decreased LCAT (lecithin-cholesterol acyltransferase)" EXACT []
synonym: "decreased LCAT activity" EXACT []
synonym: "decreased lecithin--cholesterol acyltransferase activity" EXACT []
synonym: "decreased lecithin-cholesterol acyltransferase activity" EXACT []
synonym: "decreased lecithin:cholesterol acyltransferase activity" EXACT []
synonym: "decreased phosphatidylcholine:sterol O-acyltransferase activity" EXACT []
synonym: "decreased phospholipid--cholesterol acyltransferase activity" EXACT []
is_a: MP:0011598 ! abnormal phosphatidylcholine-sterol O-acyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011601
name: abnormal glutathione peroxidase activity
def: "anomaly in the ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
synonym: "abnormal glutathione:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "abnormal GSH peroxidase activity" EXACT []
synonym: "abnormal non-selenium glutathione peroxidase activity" EXACT []
synonym: "abnormal reduced glutathione peroxidase activity" EXACT []
synonym: "abnormal selenium-glutathione peroxidase activity" EXACT []
is_a: MP:0012579 ! abnormal peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011602
name: increased glutathione peroxidase activity
def: "greater ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
synonym: "increased glutathione:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "increased GSH peroxidase activity" EXACT []
synonym: "increased non-selenium glutathione peroxidase activity" EXACT []
synonym: "increased reduced glutathione peroxidase activity" EXACT []
synonym: "increased selenium-glutathione peroxidase activity" EXACT []
is_a: MP:0011601 ! abnormal glutathione peroxidase activity
is_a: MP:0012582 ! increased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011603
name: decreased glutathione peroxidase activity
def: "reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
synonym: "decreased glutathione:hydrogen-peroxide oxidoreductase activity" EXACT []
synonym: "decreased GSH peroxidase activity" EXACT []
synonym: "decreased non-selenium glutathione peroxidase activity" EXACT []
synonym: "decreased reduced glutathione peroxidase activity" EXACT []
synonym: "decreased selenium-glutathione peroxidase activity" EXACT []
synonym: "reduced GSH peroxidase activity" EXACT []
is_a: MP:0011601 ! abnormal glutathione peroxidase activity
is_a: MP:0012580 ! decreased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011604
name: abnormal glucokinase activity
def: "anomaly in the ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate" [GO:0004340]
synonym: "abnormal ATP:D-glucose 6-phosphotransferase activity" EXACT []
synonym: "abnormal glucokinase (phosphorylating)" EXACT []
synonym: "abnormal glucose kinase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011605
name: increased glucokinase activity
def: "greater ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate" [GO:0004340]
synonym: "increased ATP:D-glucose 6-phosphotransferase activity" EXACT []
synonym: "increased glucokinase (phosphorylating)" EXACT []
synonym: "increased glucose kinase activity" EXACT []
is_a: MP:0011604 ! abnormal glucokinase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011606
name: decreased glucokinase activity
def: "reduced ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate" [GO:0004340]
synonym: "decreased ATP:D-glucose 6-phosphotransferase activity" EXACT []
synonym: "decreased glucokinase (phosphorylating)" EXACT []
synonym: "decreased glucose kinase activity" EXACT []
is_a: MP:0011604 ! abnormal glucokinase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011607
name: abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
def: "anomaly in the ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+" [GO:0004365]
synonym: "abnormal 3-phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "abnormal D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT []
synonym: "abnormal dehydrogenase, glyceraldehyde phosphate" EXACT []
synonym: "abnormal GAPDH activity" EXACT []
synonym: "abnormal glyceraldehyde phosphate dehydrogenase (NAD)" EXACT []
synonym: "abnormal glyceraldehyde-3-P-dehydrogenase activity" EXACT []
synonym: "abnormal NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "abnormal NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "abnormal NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "abnormal phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "abnormal triosephosphate dehydrogenase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011608
name: increased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
def: "greater ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+" [GO:0004365]
synonym: "increased 3-phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "increased D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT []
synonym: "increased dehydrogenase, glyceraldehyde phosphate" EXACT []
synonym: "increased GAPDH activity" EXACT []
synonym: "increased glyceraldehyde phosphate dehydrogenase (NAD)" EXACT []
synonym: "increased glyceraldehyde-3-P-dehydrogenase activity" EXACT []
synonym: "increased NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "increased NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "increased NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "increased phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "increased triosephosphate dehydrogenase activity" EXACT []
is_a: MP:0011607 ! abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011609
name: decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
def: "reduced ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+" [GO:0004365]
synonym: "decreased 3-phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "decreased D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT []
synonym: "decreased dehydrogenase, glyceraldehyde phosphate" EXACT []
synonym: "decreased GAPDH activity" EXACT []
synonym: "decreased glyceraldehyde phosphate dehydrogenase (NAD)" EXACT []
synonym: "decreased glyceraldehyde-3-P-dehydrogenase activity" EXACT []
synonym: "decreased NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "decreased NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "decreased NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT []
synonym: "decreased phosphoglyceraldehyde dehydrogenase activity" EXACT []
synonym: "decreased triosephosphate dehydrogenase activity" EXACT []
is_a: MP:0011607 ! abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-01-26T01:31:29Z

[Term]
id: MP:0011610
name: abnormal primordial germ cell apoptosis
def: "change in the timing or the number of primordial germ cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal PGC apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0020363 ! abnormal germ cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T12:13:11Z

[Term]
id: MP:0011611
name: abnormal circulating ghrelin level
def: "any anomaly in the blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland; in addition to stimulating appetite and growth, ghrelin also plays various roles in energy homeostasis, neuropathy, and in the cardiovascular and immune systems" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma ghrelin level" NARROW []
synonym: "abnormal serum ghrelin level" NARROW []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T12:46:51Z

[Term]
id: MP:0011612
name: increased circulating ghrelin level
def: "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperghrelinaemia" EXACT []
synonym: "hyperghrelinemia" EXACT []
synonym: "increased plasma ghrelin level" NARROW []
synonym: "increased serum ghrelin level" NARROW []
is_a: MP:0011611 ! abnormal circulating ghrelin level
is_a: MP:0014456 ! increased circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T12:47:30Z

[Term]
id: MP:0011613
name: decreased circulating ghrelin level
def: "less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma ghrelin level" NARROW []
synonym: "decreased serum ghrelin level" NARROW []
synonym: "hypoghrelinaemia" EXACT []
synonym: "hypoghrelinemia" EXACT []
synonym: "reduced plasma ghrelin level" NARROW []
synonym: "reduced serum ghrelin level" NARROW []
is_a: MP:0011611 ! abnormal circulating ghrelin level
is_a: MP:0014457 ! decreased circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T12:47:30Z

[Term]
id: MP:0011614
name: slow aging
def: "later than normal occurrence of the normal signs of aging" [https://orcid.org/0000-0003-3691-0324]
synonym: "ageing resistance" EXACT []
synonym: "aging resistance" EXACT []
synonym: "resistance to ageing" EXACT []
synonym: "resistance to aging" EXACT []
synonym: "slow ageing" EXACT []
is_a: MP:0010768 ! mortality/aging
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T01:41:31Z

[Term]
id: MP:0011615
name: submucous cleft palate
def: "a cleft of the palate with cardinal signs including a bifid uvula, a V-shaped notch at the back of the hard palate, and/or a translucent line in the midline of the soft palate and a short palate" [PMID:19779505]
synonym: "SMCP" EXACT []
synonym: "submucosal cleft palate" EXACT []
is_a: MP:0009890 ! cleft secondary palate
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-02-28T03:20:10Z

[Term]
id: MP:0011616
name: abnormal nonassociative learning
def: "anomaly in the process of a simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus; there is no association of one type of stimulus with another, rather it is a generalized response to the environment" [GO:0046958]
synonym: "abnormal unconditional response" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T10:53:06Z

[Term]
id: MP:0011617
name: abnormal habituation
def: "anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]
is_a: MP:0011616 ! abnormal nonassociative learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T10:53:44Z

[Term]
id: MP:0011618
name: abnormal sensitization
def: "anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a stimulus" [GO:0046960]
is_a: MP:0011616 ! abnormal nonassociative learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T10:53:57Z

[Term]
id: MP:0011619
name: abnormal dishabituation
def: "anomaly in the process in which there is a temporary recovery of response to a stimulus when a novel stimulus is added" [GO:0097270]
is_a: MP:0011616 ! abnormal nonassociative learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:07:27Z

[Term]
id: MP:0011620
name: abnormal habituation to a new environment
def: "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001413 ! abnormal response to new environment
is_a: MP:0011617 ! abnormal habituation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:13:52Z

[Term]
id: MP:0011621
name: abnormal habituation to a novel object
def: "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel object" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003461 ! abnormal response to novel object
is_a: MP:0011617 ! abnormal habituation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:13:52Z

[Term]
id: MP:0011622
name: abnormal habituation to a novel odor
def: "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel odor" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal habituation to a novel odour" EXACT []
is_a: MP:0001460 ! abnormal olfactory discrimination memory
is_a: MP:0003462 ! abnormal response to novel odor
is_a: MP:0011617 ! abnormal habituation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:13:52Z

[Term]
id: MP:0011623
name: abnormal habituation to xenobiotic
def: "anomaly in the process in which there is a progressive decline of behavioral response probability with exposure to xenobiotics" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal drug habituation" NARROW []
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic
is_a: MP:0011617 ! abnormal habituation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:13:52Z

[Term]
id: MP:0011624
name: abnormal sensitization to xenobiotic
def: "anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a xenobiotic" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009745 ! abnormal behavioral response to xenobiotic
is_a: MP:0011618 ! abnormal sensitization
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T11:14:40Z

[Term]
id: MP:0011625
name: cystolithiasis
def: "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [https://orcid.org/0000-0003-3691-0324]
synonym: "urinary bladder stones" EXACT []
synonym: "urinary calculi" EXACT []
synonym: "vesical calculus" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0005360 ! urolithiasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T12:48:58Z

[Term]
id: MP:0011626
name: orotic acid urinary bladder stones
def: "presence of caliculi, or a solid concretion or crystal aggregation formed from orotic acid, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [https://orcid.org/0000-0003-3691-0324]
synonym: "orotic acid vesical calculus" EXACT []
is_a: MP:0011625 ! cystolithiasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T12:52:40Z

[Term]
id: MP:0011627
name: decreased skin pigmentation
def: "visually detectable dilution of pigment present in the skin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0005408 ! hypopigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:10:57Z

[Term]
id: MP:0011628
name: increased mitochondrial number
def: "greater than normal number of the cellular organelles responsible for energy production" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased mitochondria number" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011629
name: decreased mitochondrial number
def: "fewer than normal number of the cellular organelles responsible for energy production" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mitochondria number" EXACT []
synonym: "reduced mitochondria number" EXACT []
synonym: "reduced mitochondrial number" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011630
name: increased mitochondrial size
def: "increased size of the cellular organelles responsible for energy production" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged mitochondria" EXACT []
synonym: "increased mitochondria size" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011631
name: decreased mitochondrial size
def: "reduced size of the cellular organelles responsible for energy production" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mitochondria size" EXACT []
synonym: "reduced mitochondria size" EXACT []
synonym: "reduced mitochondrial size" EXACT []
synonym: "small mitochondria" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011632
name: dilated mitochondrion
def: "the luminal space of one or more mitochondria is increased in volume or area, usually with an increase of contained fluid" [https://orcid.org/0000-0003-3691-0324]
synonym: "dilated mitochondria" EXACT []
synonym: "swollen mitochondria" EXACT []
synonym: "swollen mitochondrion" EXACT []
is_a: MP:0011630 ! increased mitochondrial size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011633
name: abnormal mitochondrial shape
def: "any anomaly in the characteristic surface outline or contour of a mitochondria" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal mitochondria shape" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011634
name: abnormal mitochondrial inner membrane morphology
def: "any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae" [GO:0005743]
synonym: "abnormal inner mitochondrial membrane morphology" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011635
name: abnormal mitochondrial crista morphology
def: "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
synonym: "abnormal mitochondrial cristae morphology" EXACT []
is_a: MP:0011634 ! abnormal mitochondrial inner membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011636
name: disorganized mitochondrial cristae
def: "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [https://orcid.org/0000-0003-3691-0324]
synonym: "disorganised mitochondrial cristae" EXACT []
is_a: MP:0011635 ! abnormal mitochondrial crista morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011637
name: abnormal mitochondrial matrix morphology
def: "any structural anomaly of the gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion, and contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation" [GO:0005759]
synonym: "abnormal mitochondrial lumen morphology" EXACT []
synonym: "abnormal mitochondrial stroma morphology" RELATED []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011638
name: abnormal mitochondrial chromosome morphology
def: "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
synonym: "abnormal mitochondria chromosome morphology" EXACT []
synonym: "abnormal mitochondrial DNA morphology" EXACT []
synonym: "abnormal mitochondrial genome morphology" EXACT []
synonym: "abnormal mitochondrion chromosome morphology" EXACT []
synonym: "abnormal mtDNA morphology" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011639
name: decreased mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a mammalian cell" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mitochondrial genome size" EXACT []
synonym: "decreased mtDNA amount" EXACT []
synonym: "reduced mitochondrial DNA content" EXACT []
is_a: MP:0011638 ! abnormal mitochondrial chromosome morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T01:40:51Z

[Term]
id: MP:0011640
name: abnormal aorta collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009871 ! abnormal aorta tunica adventitia morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T02:49:27Z

[Term]
id: MP:0011641
name: abnormal pulmonary collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lung collagen fibril morphology" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T02:50:37Z

[Term]
id: MP:0011642
name: abnormal bone collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T02:51:34Z

[Term]
id: MP:0011643
name: abnormal tendon collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005503 ! abnormal tendon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T02:51:58Z

[Term]
id: MP:0011644
name: abnormal oviduct epithelium motile cilium morphology
def: "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal oviduct epithelial motile cilia morphology" EXACT []
synonym: "abnormal oviduct epithelial motile cilium morphology" EXACT []
synonym: "abnormal oviduct epithelium motile cilia morphology" RELATED []
is_a: MP:0003574 ! abnormal oviduct morphology
is_a: MP:0013206 ! abnormal motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:02:05Z

[Term]
id: MP:0011645
name: absent oviduct epithelium motile cilium
def: "absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent oviduct epithelial motile cilium" EXACT []
synonym: "absent oviduct epithelium motile cilia" EXACT []
is_a: MP:0011644 ! abnormal oviduct epithelium motile cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:05:18Z

[Term]
id: MP:0011646
name: abnormal sinoatrial valve morphology
def: "any structural anomaly of the valve at the sinoatrial orifice at the opening of the sinus venosus into the primordial right atrium" [ISBN:0-683-40008-8]
synonym: "abnormal SA valve morphology" EXACT []
synonym: "abnormal sinuatrial valve morphology" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:34:39Z

[Term]
id: MP:0011647
name: absent sinoatrial valve
def: "absence of the valve at the sinoatrial orifice at the opening of the sinus venosus into the primordial right atrium" [ISBN:0-683-40008-8]
synonym: "absent SA valve" EXACT []
synonym: "absent sinuatrial valve" EXACT []
is_a: MP:0011646 ! abnormal sinoatrial valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:36:45Z

[Term]
id: MP:0011648
name: thick heart valve cusps
def: "an increase in the heart cusp wall thickness" [https://orcid.org/0000-0003-3691-0324]
synonym: "thick heart valve leaflets" EXACT []
synonym: "thickened heart valve cusps" EXACT []
synonym: "thickened heart valve leaflets" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:38:29Z

[Term]
id: MP:0011649
name: immotile respiratory cilia
def: "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [https://orcid.org/0000-0003-3691-0324]
synonym: "immotile airway cilium" BROAD []
synonym: "immotile respiratory cilium" EXACT []
is_a: MP:0011055 ! abnormal respiratory motile cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-12T03:50:15Z

[Term]
id: MP:0011650
name: abnormal cornea stroma collagen fibril morphology
def: "any structural anomaly of the connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal corneal stroma collagen fibril morphology" EXACT []
is_a: MP:0005300 ! abnormal cornea stroma morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-18T07:12:54Z

[Term]
id: MP:0011651
name: abnormal circulating histidine level
def: "the amount of the amino acid histidine in the blood is more or less than expected" [MGI:llw2]
is_a: MP:0005311 ! abnormal circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-18T08:22:18Z

[Term]
id: MP:0011652
name: increased circulating histidine level
def: "the amount of the amino acid histidine in the blood is more than expected" [MGI:llw2]
synonym: "histidinaemia" RELATED []
synonym: "histidinemia" RELATED []
is_a: MP:0011651 ! abnormal circulating histidine level
is_a: MP:0014530 ! increased circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-18T08:25:23Z

[Term]
id: MP:0011653
name: decreased circulating histidine level
def: "the amount of the amino acid histidine in the blood is less than expected" [MGI:llw2]
synonym: "reduced circulating histidine level" EXACT []
is_a: MP:0011651 ! abnormal circulating histidine level
is_a: MP:0014531 ! decreased circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-18T08:25:23Z

[Term]
id: MP:0011654
name: histidinuria
def: "increased excretion of histidine and related imidazole metabolites in urine" [MGI:llw2]
synonym: "increased urine histidine level" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003311 ! aminoaciduria
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-18T08:29:04Z

[Term]
id: MP:0011655
name: abnormal systemic artery morphology
def: "any structural anomaly of the arteries that carry oxygenated blood away from the heart to the body, as opposed to the pulmonary arteries, which carry deoxygenated blood to the lungs" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "systemic artery anomaly" BROAD []
synonym: "systemic artery dysplasia" NARROW []
xref: Fyler:2600
is_a: MP:0002191 ! abnormal artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-19T11:32:37Z

[Term]
id: MP:0011656
name: coronary arterio-venous fistula
def: "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "coronary arteriovenous fistula" EXACT []
xref: Fyler:2240
is_a: MP:0010476 ! coronary fistula
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-19T11:41:27Z

[Term]
id: MP:0011657
name: coronary-cameral fistula
def: "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering a chamber of the heart (coronary-cameral fistula)" [http://emedicine.medscape.com]
subset: CvDC_Terms
is_a: MP:0010476 ! coronary fistula
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-19T11:43:16Z

[Term]
id: MP:0011658
name: interrupted aortic arch, type a
def: "complete discontinuation/blockage between the ascending and descending aorta with the interruption located distal to the subclavian artery that is ipsilateral to the second carotid artery" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "interrupted aortic arch type a" EXACT []
is_a: MP:0004157 ! interrupted aortic arch
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-19T11:46:03Z

[Term]
id: MP:0011659
name: interrupted aortic arch, type b
def: "complete discontinuation/blockage between the ascending and descending aorta with the interruption located between second carotid artery and ipsilateral subclavian artery" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "interrupted aortic arch type b" EXACT []
xref: Fyler:1252
is_a: MP:0004157 ! interrupted aortic arch
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-19T11:46:03Z

[Term]
id: MP:0011660
name: ectopia cordis
def: "congenital condition in which the heart is exposed and/or protruding from the thorax due to abnormal development of the sternum, pericardium and/or the abdominal wall" [ISBN:0-683-40008-8]
subset: CvDC_Terms
xref: Fyler:0170
xref: Fyler:170
is_a: MP:0006065 ! abnormal heart position or orientation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T10:20:09Z

[Term]
id: MP:0011661
name: persistent truncus arteriosus type i
def: "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is characterized by origin of a single pulmonary trunk from the left lateral aspect of the common trunk, with branching of the left and right pulmonary arteries from the pulmonary trunk" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "PTA, type I" EXACT []
xref: Fyler:0510
xref: Fyler:510
is_a: MP:0002633 ! persistent truncus arteriosus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T10:48:42Z

[Term]
id: MP:0011662
name: persistent truncus arteriosus type ii
def: "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type II is characterized by separate but proximate origins of the left and right pulmonary arterial branches from the posterolateral aspect of the common arterial trunk" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "PTA, type II" EXACT []
xref: Fyler:0520
xref: Fyler:520
is_a: MP:0002633 ! persistent truncus arteriosus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T10:48:42Z

[Term]
id: MP:0011663
name: persistent truncus arteriosus type iii
def: "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; in type iii the branch pulmonary arteries originate independently from the common arterial trunk or aortic arch, most often from the left and right lateral aspects of the trunk; this occasionally occurs with origin of one pulmonary artery from the underside of the aortic arch, usually from a ductus arteriosus" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "PTA, type III" EXACT []
xref: Fyler:0530
xref: Fyler:530
is_a: MP:0002633 ! persistent truncus arteriosus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:11:47Z

[Term]
id: MP:0011664
name: persistent truncus arteriosus type iv
def: "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is a form of the lesion with neither pulmonary arterial branch arises from the common trunk, and is more commonly recognized to be a form of pulmonary atresia with ventricular septal defect rather than truncus arteriosus" [http://emedicine.medscape.com]
subset: CvDC_Terms
synonym: "persistent truncus arteriosus type 4" EXACT []
synonym: "PTA, type IV" EXACT []
xref: Fyler:0540
xref: Fyler:540
is_a: MP:0002633 ! persistent truncus arteriosus
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:12:08Z

[Term]
id: MP:0011665
name: d-loop transposition of the great arteries
def: "complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]
synonym: "complete transposition of the great arteries" EXACT []
synonym: "D-TGA" EXACT []
xref: Fyler:0700
xref: Fyler:700
is_a: MP:0004110 ! transposition of great arteries
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:24:23Z

[Term]
id: MP:0011666
name: double outlet right ventricle, ventricular defect committed to aorta
def: "a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "DORV, ventricular defect committed to aorta" EXACT []
xref: Fyler:0602
xref: Fyler:602
is_a: MP:0000284 ! double outlet right ventricle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:38:09Z

[Term]
id: MP:0011667
name: double outlet right ventricle with atrioventricular septal defect
def: "a form of DORV in which there is also a complete atrioventricular canal" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "AV canal" EXACT []
synonym: "DORV + AVSD (AV canal)" EXACT []
xref: Fyler:0606
xref: Fyler:606
is_a: MP:0000284 ! double outlet right ventricle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:38:09Z

[Term]
id: MP:0011668
name: double outlet right ventricle, Taussig bing type
def: "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "DORV, Taussing bing" EXACT []
synonym: "double outlet right ventricle with subpulmonary VSD" RELATED []
xref: Fyler:0610
xref: Fyler:610
is_a: MP:0000284 ! double outlet right ventricle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T11:38:09Z

[Term]
id: MP:0011669
name: double outlet right ventricle, doubly committed ventricular septal defect
def: "a form of DORV in which there are two ventricular septal defects, one below the aorta and one below the pulmonary artery and the left ventricular outflow is equally shared by the aorta and pulmonary artery" [http://emedicine.medscape.com, https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:0604
xref: Fyler:604
is_a: MP:0000284 ! double outlet right ventricle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T12:31:42Z

[Term]
id: MP:0011670
name: double outlet right ventricle, noncommitted ventricular septal defect
def: "a form of DORV in which the ventricular septal defect is distant from both the aorta and pulmonary artery and blood mixes in the right ventricle before entering these vessels, with the majority of deoxygenated blood entering the aorta" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "double outlet right ventricle, ventricular septal defect uncommitted" EXACT []
xref: Fyler:0603
xref: Fyler:603
is_a: MP:0000284 ! double outlet right ventricle
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T12:32:41Z

[Term]
id: MP:0011671
name: balanced complete atrioventricular canal
def: "a balanced complete atrioventricular septal defect occurs when the atrioventricular junction is connected equally to the right and left ventricles so that each ventricle receives a similar amount of blood and the ventricles are symmetrical in size" [https://radiologykey.com/atrioventricular-septal-defects/]
subset: CvDC_Terms
synonym: "balanced complete atrioventricular septal defect" EXACT []
xref: Fyler:1124
is_a: MP:0010413 ! complete atrioventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T01:32:23Z

[Term]
id: MP:0011672
name: unbalanced complete atrioventricular canal, left dominant
def: "an unbalanced form of a complete atrioventricular septal defect where the atrioventricular junction is predominantly committed to the left ventricle; in left ventricular dominance, there can be hypoplasia of the right ventricle and pulmonary artery" [https://clinicalgate.com/atrioventricular-septal-defect-echocardiographic-assessment/]
subset: CvDC_Terms
synonym: "unbalanced complete atrioventricular septal defect, left dominant" EXACT []
xref: Fyler:1125
is_a: MP:0011673 ! unbalanced complete common atrioventricular canal
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T01:32:23Z

[Term]
id: MP:0011673
name: unbalanced complete common atrioventricular canal
def: "an unbalanced complete atrioventricular septal defect occurs when the atrioventricular junction is predominantly committed to either the right or left ventricle, leading to hypoplasia of the opposing ventricle receiving the smaller amount of blood" [https://radiologykey.com/atrioventricular-septal-defects/]
subset: CvDC_Terms
synonym: "unbalanced complete atrioventricular septal defect" EXACT []
xref: Fyler:1132
is_a: MP:0010413 ! complete atrioventricular septal defect
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T01:32:23Z

[Term]
id: MP:0011674
name: multiple major aortopulmonary collateral arteries
def: "small ectopic arteries or arterial branches that arise from the aorta or its first-order branches and are distally connected to the pulmonary arterial vasculature" [PMID:35782757]
subset: CvDC_Terms
synonym: "MAPCAS" RELATED []
xref: Fyler:2271
is_a: MP:0010635 ! aorta pulmonary collateral arteries
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T01:57:13Z

[Term]
id: MP:0011675
name: double aortic arch, balanced arches
def: "defect in which the aortic arch splits into equally sized large left and right branches, encircling the trachea and esophagus, before becoming one tube to go to the lower body" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
xref: Fyler:2780
is_a: MP:0004159 ! double aortic arch
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T01:58:34Z

[Term]
id: MP:0011676
name: aortic arch obstruction
def: "any impediment or blockage causing a cessation or reversal of the normal flow of the blood through the aortic arch" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "transverse arch obstruction" EXACT []
xref: Fyler:1241
is_a: MP:0004113 ! abnormal aortic arch morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T02:00:44Z

[Term]
id: MP:0011677
name: abnormal olfactory sensory neuron physiology
def: "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal olfactory neuron physiology" EXACT []
is_a: MP:0010055 ! abnormal sensory neuron physiology
is_a: MP:0012020 ! abnormal olfactory epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T03:00:44Z

[Term]
id: MP:0011678
name: abnormal vomeronasal sensory neuron physiology
def: "any functional anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [https://orcid.org/0000-0003-3691-0324]
comment: This organ is believed to function in sensing pheromones. While the structure has been thought to be absent from higher primate adults, some data suggests that a form may be present in adult humans.
is_a: MP:0010055 ! abnormal sensory neuron physiology
is_a: MP:0013596 ! abnormal vomeronasal organ physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T03:00:44Z

[Term]
id: MP:0011679
name: abnormal vomeronasal sensory neuron morphology
def: "any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001001 ! abnormal chemoreceptor morphology
is_a: MP:0002243 ! abnormal vomeronasal organ morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-20T03:06:45Z

[Term]
id: MP:0011680
name: tricuspid valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the tricuspid valve, typically resulting in decreased size" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "hypoplastic right atrioventricular valve" EXACT []
synonym: "hypoplastic right AV valve" EXACT []
synonym: "hypoplastic tricuspid valve" EXACT []
synonym: "right atrioventricular valve hypoplasia" EXACT []
synonym: "right AV valve hypoplasia" EXACT []
xref: Fyler:1720
is_a: MP:0031557 ! small tricuspid valve
is_a: MP:0031573 ! atrioventricular valve hypoplasia
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T09:13:56Z

[Term]
id: MP:0011681
name: atrium cyst
def: "presence of one or more abnormal membranous sacs in any portion of the paired upper chambers of the heart" [https://orcid.org/0000-0003-3691-0324]
synonym: "atrial cyst" EXACT []
synonym: "atrial cysts" EXACT []
synonym: "atrium cysts" EXACT []
synonym: "cystic atria" EXACT []
synonym: "cystic atrium" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
is_a: MP:0031310 ! abnormal cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T09:53:10Z

[Term]
id: MP:0011682
name: renal glomerulus cyst
def: "presence of one or more abnormal membranous sacs in any portion of the renal glomerulus" [https://orcid.org/0000-0003-3691-0324]
synonym: "cystic glomeruli" EXACT []
synonym: "cystic glomerulus" EXACT []
synonym: "cystic kidney glomeruli" EXACT []
synonym: "cystic kidney glomerulus" EXACT []
synonym: "cystic renal glomeruli" EXACT []
synonym: "cystic renal glomerulus" EXACT []
synonym: "glomerular cysts" EXACT []
synonym: "renal glomerulus cysts" EXACT []
is_a: MP:0003675 ! kidney cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T09:55:46Z

[Term]
id: MP:0011683
name: dual inferior vena cava
def: "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [https://orcid.org/0000-0003-3691-0324, PMID:10835118]
synonym: "congenital duplicated inferior vena cava" EXACT []
synonym: "double inferior vena cava" EXACT []
synonym: "double IVC" EXACT []
synonym: "dual inferior vena cavae" EXACT []
synonym: "duplicated inferior vena cava" EXACT []
is_a: MP:0006063 ! abnormal inferior vena cava morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T09:57:17Z

[Term]
id: MP:0011684
name: coronary-cameral fistula to heart right ventricle
def: "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle" [https://orcid.org/0000-0003-3691-0324]
subset: CvDC_Terms
synonym: "coronary-cameral fistula to right ventricle" EXACT []
xref: Fyler:2233
is_a: MP:0003920 ! abnormal heart right ventricle morphology
is_a: MP:0011657 ! coronary-cameral fistula
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T10:15:15Z

[Term]
id: MP:0011685
name: abnormal limb paddle morphology
def: "any structural anomaly of the transient developing limb structure that develops from the limb bud; it is a dorsoventral flattening of the limb bud structure and develops into the foot plate" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006279 ! abnormal limb development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-04-27T10:38:17Z

[Term]
id: MP:0011686
name: increased epidermal stem cell number
def: "greater than expected number of somatic stem cells that are part of the epidermis" [CL:1000428, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011004 ! abnormal epidermal stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T10:15:24Z

[Term]
id: MP:0011687
name: decreased epidermal stem cell number
def: "a reduction in the number of somatic stem cells that are part of the epidermis" [CL:1000428, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011004 ! abnormal epidermal stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T10:15:25Z

[Term]
id: MP:0011688
name: absent epidermal stem cells
def: "absence of the somatic stem cells that are part of the epidermis" [CL:1000428, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011687 ! decreased epidermal stem cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T10:15:26Z

[Term]
id: MP:0011689
name: absent neutrophils
def: "absence of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [CL:0000775, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000222 ! decreased neutrophil cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T11:15:58Z

[Term]
id: MP:0011690
name: absent basophils
def: "absence of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation" [CL:0000767]
is_a: MP:0002607 ! decreased basophil cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T12:09:08Z

[Term]
id: MP:0011691
name: absent bronchioalveolar stem cells
def: "absence of the respiratory stem cells found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury" [CL:0002638]
is_a: MP:0010830 ! decreased bronchioalveolar stem cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:13:13Z

[Term]
id: MP:0011692
name: increased chondrocyte number
def: "greater number of polymorphic cells that form cartilage" [CL:0000138]
is_a: MP:0000166 ! abnormal chondrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:24:38Z

[Term]
id: MP:0011693
name: absent chondrocytes
def: "absence of polymorphic cells that form cartilage" [CL:0000138]
is_a: MP:0000167 ! decreased chondrocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:25:06Z

[Term]
id: MP:0011694
name: absent eosinophils
def: "any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin" [CL:0000771]
is_a: MP:0005012 ! decreased eosinophil cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:30:36Z

[Term]
id: MP:0011695
name: absent hematopoietic stem cells
def: "absence of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent haematopoietic stem cells" EXACT []
synonym: "absent HSCs" EXACT []
is_a: MP:0004810 ! decreased hematopoietic stem cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:35:28Z

[Term]
id: MP:0011696
name: absent mast cells
def: "any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream." [CL:0000097]
is_a: MP:0000336 ! decreased mast cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T01:37:43Z

[Term]
id: MP:0011697
name: lens vacuoles
def: "abnormal presence of fluid-filled cavities in the cytoplasm of the transparent structure of the eye responsible for focusing light" [https://orcid.org/0000-0002-6490-7723, MGI:llw2]
synonym: "vacuolated lens" EXACT []
is_a: MP:0005545 ! abnormal lens development
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T02:01:06Z

[Term]
id: MP:0011698
name: abnormal brown adipose tissue physiology
def: "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005666 ! abnormal adipose tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T02:07:12Z

[Term]
id: MP:0011699
name: abnormal brown adipose tissue thermogenesis
def: "any anomaly in the process of heat production in brown adipocytes" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011698 ! abnormal brown adipose tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-11T03:31:50Z

[Term]
id: MP:0011700
name: increased cumulus expansion
def: "greater ability of the ovarian cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased ovarian cumulus expansion" EXACT []
synonym: "increased ovarian cumulus growth" EXACT []
is_a: MP:0009373 ! abnormal cumulus expansion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T10:58:29Z

[Term]
id: MP:0011701
name: decreased cumulus expansion
def: "reduced ability of the ovarian cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired ovarian cumulus expansion" EXACT []
synonym: "reduced ovarian cumulus growth" EXACT []
is_a: MP:0009373 ! abnormal cumulus expansion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T10:58:29Z

[Term]
id: MP:0011702
name: abnormal fibroblast proliferation
def: "anomaly in the ability of a fibroblast cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
xref: CL:0000057
xref: GO:0048144
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0020414 ! abnormal fibroblast physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:21:46Z

[Term]
id: MP:0011703
name: increased fibroblast proliferation
def: "greater the expansion rate of a fibroblast cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011702 ! abnormal fibroblast proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:22:45Z

[Term]
id: MP:0011704
name: decreased fibroblast proliferation
def: "reduction in the expansion rate of a fibroblast cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced fibroblast proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011702 ! abnormal fibroblast proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:22:45Z

[Term]
id: MP:0011705
name: absent fibroblast proliferation
def: "failure of a fibroblast cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "failure of fibroblast proliferation" EXACT []
is_a: MP:0011704 ! decreased fibroblast proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:22:45Z

[Term]
id: MP:0011706
name: abnormal fibroblast migration
def: "any anomaly of fibroblast cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761]
xref: CL:0000057
xref: GO:0010761
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0020414 ! abnormal fibroblast physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:38:55Z

[Term]
id: MP:0011707
name: impaired fibroblast cell migration
def: "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011708 ! decreased fibroblast cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:42:49Z

[Term]
id: MP:0011708
name: decreased fibroblast cell migration
def: "reduced frequency of or less rapid fibroblast cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011706 ! abnormal fibroblast migration
is_a: MP:0011805 ! decreased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:42:49Z

[Term]
id: MP:0011709
name: increased fibroblast cell migration
def: "greater frequency of or more rapid fibroblast cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011706 ! abnormal fibroblast migration
is_a: MP:0011804 ! increased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:42:49Z

[Term]
id: MP:0011710
name: enhanced osteoblast differentiation
def: "increased ability or increased rate of production of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
synonym: "increased osteoblast differentiation" RELATED []
is_a: MP:0008395 ! abnormal osteoblast differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:56:40Z

[Term]
id: MP:0011711
name: impaired osteoblast differentiation
def: "reduced ability or inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [CL:0000062]
synonym: "decreased osteoblast differentiation" RELATED []
is_a: MP:0008395 ! abnormal osteoblast differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:56:40Z

[Term]
id: MP:0011712
name: arrested osteoblast differentiation
def: "inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell, due to a block in the process to create a mature osteoblast" [CL:0000062]
synonym: "absent osteoblast differentiation" RELATED []
is_a: MP:0011711 ! impaired osteoblast differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T11:56:40Z

[Term]
id: MP:0011713
name: abnormal circulating interleukin-8 level
def: "anomaly in the amount in the blood of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0008588 ! abnormal circulating interleukin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:06:52Z

[Term]
id: MP:0011714
name: increased circulating interleukin-8 level
def: "increase in the amount in the blood of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0011713 ! abnormal circulating interleukin-8 level
is_a: MP:0014497 ! increased circulating interleukin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:06:52Z

[Term]
id: MP:0011715
name: decreased circulating interleukin-8 level
def: "reduction in the amount in the blood of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0011713 ! abnormal circulating interleukin-8 level
is_a: MP:0014498 ! decreased circulating interleukin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:06:52Z

[Term]
id: MP:0011716
name: abnormal interleukin-8 secretion
def: "anomaly in the production or release of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0008568 ! abnormal interleukin secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:08:08Z

[Term]
id: MP:0011717
name: increased interleukin-8 secretion
def: "increase in the production or release of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0011716 ! abnormal interleukin-8 secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:08:08Z

[Term]
id: MP:0011718
name: decreased interleukin-8 secretion
def: "reduction in the production or release of a member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response, is secreted by variety of cell types and induces chemotaxis of neutrophils and other inflammatory cells" [MESH:D12.644.276.374.200.120.800]
is_a: MP:0011716 ! abnormal interleukin-8 secretion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:08:08Z

[Term]
id: MP:0011719
name: abnormal natural killer cell mediated cytotoxicity
def: "any anomaly in the process of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors" [GO:0042267]
synonym: "abnormal killer activity" BROAD []
synonym: "abnormal natural killer cell mediated cell death" EXACT []
synonym: "abnormal natural killer cell mediated cell killing" EXACT []
synonym: "abnormal natural killer cell mediated cytolysis" EXACT []
synonym: "abnormal natural killer-cell mediated cytolysis" EXACT []
synonym: "abnormal NK cell mediated cell death" EXACT []
synonym: "abnormal NK cell mediated cell killing" EXACT []
synonym: "abnormal NK cell mediated cytolysis" EXACT []
synonym: "abnormal NK cell mediated cytotoxicity" EXACT []
xref: GO:0042267
is_a: MP:0010766 ! abnormal NK cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-05-18T03:45:46Z

[Term]
id: MP:0011720
name: abnormal ossification involved in bone remodeling
def: "any anomaly in the formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli" [GO:0043932]
is_a: MP:0002998 ! abnormal bone remodeling
is_a: MP:0008271 ! abnormal bone ossification
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-07-11T09:23:05Z

[Term]
id: MP:0011721
name: abnormal bone mineralization involved in bone maturation
def: "anomaly in the deposition of calcium phosphate in bone tissue, involved in the progression of the developing skeleton from its formation to its mature state" [GO:0035630]
is_a: MP:0002896 ! abnormal bone mineralization
is_a: MP:0011722 ! abnormal ossification involved in bone maturation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-07-11T09:37:33Z

[Term]
id: MP:0011722
name: abnormal ossification involved in bone maturation
def: "anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the developing skeleton from its formation to its mature state" [GO:0043931]
synonym: "abnormal ossification involved in skeletal development" EXACT []
is_a: MP:0008271 ! abnormal bone ossification
is_a: MP:0014294 ! abnormal skeletal maturation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-07-11T09:39:42Z

[Term]
id: MP:0011723
name: ectopic neuron
def: "appearance of a neuron or group of neurons in a region where it is not normally found" [https://orcid.org/0000-0003-3691-0324]
synonym: "neuronal ectopia" EXACT []
synonym: "neuronal heterotopia" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:37:58Z

[Term]
id: MP:0011724
name: ectopic cortical neuron
def: "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [https://orcid.org/0000-0003-3691-0324]
synonym: "cortical neuron ectopia" EXACT []
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:38:52Z

[Term]
id: MP:0011725
name: neuronal leptomeningeal ectopia
def: "during development, migrating cortical neurons fail to stop at the border of the marginal zone and continue through this layer and occasionally through the pial-glial layer into the meninges" [PMID:9184108]
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:39:48Z

[Term]
id: MP:0011726
name: ectopic Cajal-Retzius cell
def: "appearance of a Cajal-Retzius cell in a region where it is not normally found" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008030 ! abnormal Cajal-Retzius cell morphology
is_a: MP:0011723 ! ectopic neuron
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:40:54Z

[Term]
id: MP:0011727
name: ectopic ovary
def: "one or both of the ovaries located outside the normal pathway of descent from the lumbar region to a shallow depression on the lateral wall of the pelvis known as the ovarian fossa; the fossa usually lies beneath the external iliac artery and in front of the ureter and the internal iliac artery; ovarian maldescent may be associated with Mullerian malformations" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic ovarian tissue" EXACT []
synonym: "maldescended ovaries" EXACT []
synonym: "ovarian ectopia" EXACT []
synonym: "ovarian ectopy" EXACT []
synonym: "ovarian maldescent" EXACT []
synonym: "ovary ectopia" EXACT []
is_a: MP:0020491 ! abnormal ovary topology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:50:01Z

[Term]
id: MP:0011728
name: abnormal pineal gland physiology
def: "any functional anomaly of the small flattened endocrine gland located in the depression between the superior colliculi of the brain" [MGI:llw2]
synonym: "abnormal conarium physiology" EXACT []
synonym: "abnormal corpus pineale physiology" EXACT []
synonym: "abnormal epiphysis cerebri physiology" EXACT []
synonym: "abnormal glandula pinealis physiology" EXACT []
synonym: "abnormal pineal body function" EXACT []
synonym: "abnormal pineal body physiology" EXACT []
synonym: "abnormal pineal gland function" EXACT []
is_a: MP:0013570 ! abnormal neuroendocrine gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:54:58Z

[Term]
id: MP:0011729
name: abnormal pineal gland melatonin secretion
def: "anomaly in the production and/or release of a catecholamine hormone by the pineal body that controls behavior influenced by seasonal changes" [MGI:llw2]
is_a: MP:0011728 ! abnormal pineal gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T02:57:00Z

[Term]
id: MP:0011730
name: increased myelin sheath thickness
def: "increase in the depth of the insulating envelope that surrounds nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003871 ! abnormal myelin sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:27:40Z

[Term]
id: MP:0011731
name: decreased myelin sheath thickness
def: "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced myelin sheath thickness" EXACT []
is_a: MP:0003871 ! abnormal myelin sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:28:04Z

[Term]
id: MP:0011732
name: decreased somite size
def: "reduced size of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced somite size" EXACT []
synonym: "small somites" EXACT []
is_a: MP:0005222 ! abnormal somite size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:33:36Z

[Term]
id: MP:0011733
name: fused somites
def: "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [https://orcid.org/0000-0003-4606-0597]
synonym: "fusion of somites" EXACT []
synonym: "somite fusion" EXACT []
is_a: MP:0001688 ! abnormal somite development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:34:50Z

[Term]
id: MP:0011734
name: abnormal urine ammonia level
def: "any change in the amount of ammonia in urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urine ammonium level" NARROW []
is_a: MP:0009643 ! abnormal urine homeostasis
is_a: MP:0030604 ! abnormal ammonia homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:39:05Z

[Term]
id: MP:0011735
name: increased urine ammonia level
def: "a greater amount of ammonia in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased ammonium excretion" EXACT []
synonym: "increased urine ammonium level" NARROW []
is_a: MP:0011734 ! abnormal urine ammonia level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:39:53Z

[Term]
id: MP:0011736
name: decreased urine ammonia level
def: "a reduced amount of ammonia in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ammonium excretion" EXACT []
synonym: "decreased urine ammonium level" NARROW []
synonym: "reduced ammonium excretion" EXACT []
synonym: "reduced urine ammonium level" EXACT []
is_a: MP:0011734 ! abnormal urine ammonia level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:39:53Z

[Term]
id: MP:0011737
name: hypodipsia
def: "abnormally diminished thirst with a consequential reduction of fluid intake; often related to dysfunction of the thirst osmoreceptor in the anterior hypothalamus" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypodypsia" EXACT []
is_a: MP:0001422 ! abnormal drinking behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:48:47Z

[Term]
id: MP:0011738
name: anasarca
def: "widespread swelling due to effusion of serous fluid into the extracellular space, especially into the connective tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "extreme generalized edema" EXACT []
synonym: "extreme generalized oedema" EXACT []
synonym: "generalized massive edema" EXACT []
synonym: "generalized massive oedema" EXACT []
is_a: MP:0013807 ! generalized edema
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T03:54:03Z

[Term]
id: MP:0011739
name: abnormal Boettcher cell morphology
def: "any structural anomaly of the polyhedral cells located on the basilar membrane beneath the Claudius cells in the basal turn of the cochlea, and considered supporting cells for the organ of Corti; Boettcher cells interweave with each other, project microvilli into the intercellular space, show high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport" [CL:0002084, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Boettcher's cell morphology" RELATED []
synonym: "abnormal Bottcher cell morphology" EXACT []
synonym: "abnormal Bottcher's cell morphology" EXACT []
xref: CL:0002084
is_a: MP:0000031 ! abnormal cochlea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:03:51Z

[Term]
id: MP:0011740
name: abnormal urine nitrite level
def: "anomaly in the amount of nitrite (NO2-) in the urine; may be suggestive of impaired nitric oxide (NO) release, or of a urinary tract infection" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:07:53Z

[Term]
id: MP:0011741
name: increased urine nitrite level
def: "higher than normal amount of nitrite (NO2-) in the urine, usually indicative of a urinary tract infection; commonly a result of the action of Escherichia coli, Proteus vulgaris, and other microorganisms that may reduce nitrates" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased nitrite excretion" EXACT []
synonym: "nitrituria" EXACT []
is_a: MP:0011740 ! abnormal urine nitrite level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:08:11Z

[Term]
id: MP:0011742
name: decreased urine nitrite level
def: "lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nitrite excretion" EXACT []
synonym: "reduced nitrite excretion" EXACT []
synonym: "reduced urine nitrite level" EXACT []
is_a: MP:0011740 ! abnormal urine nitrite level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:08:29Z

[Term]
id: MP:0011743
name: abnormal Golgi apparatus morphology
def: "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]
synonym: "abnormal Golgi complex morphology" EXACT []
synonym: "abnormal Golgi ribbon morphology" EXACT []
is_a: MP:0014239 ! abnormal intracellular organelle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:11:52Z

[Term]
id: MP:0011744
name: abnormal kidney epithelial cell primary cilium physiology
def: "any functional anomaly of the non-motile primary cilia found on renal epithelial cells and thought to act as a mechanical sensor to detect renal tubular fluid; impaired mechanical response of primary cilia to physiological fluid flow, or abnormalities in intracellular Ca2+ increase in response to fluid stress may alter renal (tubular) cell proliferation and differentiation and lead to renal cyst formation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal kidney epithelial cell primary cilia physiology" EXACT []
synonym: "abnormal renal epithelial cell primary cilia physiology" EXACT []
synonym: "abnormal renal epithelial cell primary cilium physiology" EXACT []
synonym: "abnormal renal monocilium physiology" EXACT []
synonym: "abnormal renal primary cilium physiology" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0013211 ! abnormal nonmotile primary cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-09-27T04:19:00Z

[Term]
id: MP:0011745
name: isolation of the left subclavian artery
def: "the loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus" [PMID:16039248]
xref: Fyler:2732
is_a: MP:0010464 ! abnormal aortic arch and aortic arch branch attachment
is_a: MP:0010488 ! abnormal left subclavian artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-01T01:54:32Z

[Term]
id: MP:0011746
name: spleen fibrosis
def: "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [https://orcid.org/0000-0003-3691-0324]
synonym: "fibrotic spleen" EXACT []
is_a: MP:0000689 ! abnormal spleen morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-18T02:34:41Z

[Term]
id: MP:0011747
name: myelofibrosis
def: "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
synonym: "bone marrow fibrosis" EXACT []
synonym: "myelosclerosis" EXACT []
synonym: "osteomyelofibrosis" EXACT []
is_a: MP:0002397 ! abnormal bone marrow morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-18T02:38:33Z

[Term]
id: MP:0011748
name: intestinal fibrosis
def: "formation of fibrous tissue in any part of the intestine as a result of repair or a reactive process" [https://orcid.org/0000-0003-3691-0324]
synonym: "intestinal adhesions" EXACT []
synonym: "intestinal synechia" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-18T03:09:50Z

[Term]
id: MP:0011749
name: perivascular fibrosis
def: "invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001614 ! abnormal blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-18T03:46:04Z

[Term]
id: MP:0011750
name: abnormal seminiferous tubule epithelium morphology
alt_id: MP:0006304
def: "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal male germinal epithelium morphology" EXACT []
synonym: "abnormal seminiferous epithelium morphology" EXACT []
synonym: "abnormal seminiferous tubule epithelial tissue morphology" EXACT []
synonym: "abnormal seminiferous tubule wall morphology" EXACT [UBERON:0004813]
is_a: MP:0002216 ! abnormal seminiferous tubule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-23T03:20:20Z

[Term]
id: MP:0011751
name: abnormal X-Y chromosome synapsis during male meiosis
def: "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
synonym: "abnormal X-Y chromosome pairing during male meiosis" RELATED []
is_a: MP:0005169 ! abnormal male meiosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-26T03:21:28Z

[Term]
id: MP:0011752
name: abnormal X-Y chromosome synaptonemal complex assembly during male meiosis
def: "an anomaly in the process in which forms the structure that holds the X and Y chomosomes together during prophase I of male meiosis and results in exchange of X and Y chromatin during prophase I, or results in exchange of X and Y chromatin outside the chromatin associated with the pseudoautosomal region" [MGI:llw2]
is_a: MP:0005169 ! abnormal male meiosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-26T03:37:16Z

[Term]
id: MP:0011753
name: decreased podocyte number
def: "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased glomerular epithelial cell number" EXACT []
synonym: "decreased glomerular visceral epithelial cell number" EXACT []
synonym: "podocytopenia" EXACT []
synonym: "reduced glomerular epithelial cell number" EXACT []
synonym: "reduced glomerular visceral epithelial cell number" EXACT []
synonym: "reduced podocyte number" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-26T04:30:36Z

[Term]
id: MP:0011754
name: abnormal kidney collecting duct intercalated cell morphology
def: "any structural anomaly of any of the functionally distinct subtypes of cells (alpha or beta) found on the kidney collecting duct epithelium that regulate acid-base homeostasis and play an important role in the kidney's response to acidosis and alkalosis; alpha-intercalated cells secrete acid whereas beta-intercalated cells secrete base; metabolic acidosis results in the conversion of beta- cells to alpha-intercalated cells giving the kidney a greater ability to secrete protons and return pH to the normal range" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011843 ! abnormal kidney collecting duct epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T11:58:19Z

[Term]
id: MP:0011755
name: abnormal kidney collecting duct alpha-intercalated cell morphology
def: "any structural anomaly of the tall, columnar epithelial cells found on the kidney collecting duct epithelium which secrete acid (via an apical H+-ATPase and H+/K+ exchanger) in the form of hydrogen ions and reabsorb bicarbonate (via band 3, a basolateral Cl-/HCO3- exchanger);damage to the alpha-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal collecting duct alpha-intercalated cells" EXACT []
synonym: "abnormal collecting duct type A intercalated cells" EXACT []
synonym: "abnormal kidney collecting duct A-type intercalated cells" EXACT []
is_a: MP:0011754 ! abnormal kidney collecting duct intercalated cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T11:58:19Z

[Term]
id: MP:0011756
name: abnormal kidney collecting duct beta-intercalated cell morphology
def: "any structural anomaly of the shorter, flatter cells found on the kidney collecting duct epithelium which secrete bicarbonate (via pendrin, a specialized apical Cl-/HCO3- exchanger) and reabsorb acid (via a basal H+-ATPase)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal collecting duct beta-intercalated cells" EXACT []
synonym: "abnormal collecting duct type B intercalated cells" EXACT []
synonym: "abnormal kidney collecting duct B-type intercalated cells" EXACT []
is_a: MP:0011754 ! abnormal kidney collecting duct intercalated cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T11:58:19Z

[Term]
id: MP:0011757
name: abnormal kidney collecting duct principal cell morphology
def: "any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011843 ! abnormal kidney collecting duct epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T02:32:19Z

[Term]
id: MP:0011758
name: renal ischemia
def: "inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of a blood vessel; a significant cause of renal dysfunction and cortical and medullary necrosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "kidney ischaemia" EXACT []
synonym: "kidney ischemia" EXACT []
synonym: "nephric ischaemia" EXACT []
synonym: "nephric ischemia" EXACT []
synonym: "renal ischaemia" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T02:34:27Z

[Term]
id: MP:0011759
name: absent Rathke's pouch
def: "absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent craniobuccal pouch" EXACT []
synonym: "absent craniopharyngeal pouch" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T02:36:48Z

[Term]
id: MP:0011760
name: abnormal ureteric bud tip morphology
def: "any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ureteric ampulla morphology" EXACT []
synonym: "abnormal ureteric tip morphology" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T03:41:43Z

[Term]
id: MP:0011761
name: abnormal ureteric bud trunk morphology
def: "any structural anomaly of the ureteric bud cells that elongate to form a rigid structure (stalk) consisting of polarized epithelial cells without branching; the stalks differentiate into the collecting system of the mature kidney, while the tip cells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into nephrons" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ureteric bud stalk morphology" EXACT []
synonym: "abnormal ureteric stalk morphology" EXACT []
synonym: "abnormal ureteric trunk morphology" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-10-29T03:41:43Z

[Term]
id: MP:0011762
name: renal/urinary system inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the renal/urinary system; may involve inflammation of the urethra, urinary bladder, ureters or kidneys" [https://orcid.org/0000-0002-6490-7723]
synonym: "urinary tract inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005502 ! abnormal renal/urinary system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T10:57:04Z

[Term]
id: MP:0011763
name: urethritis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the urethra, usually caused by an infection" [https://orcid.org/0000-0002-6490-7723]
synonym: "urethra inflammation" EXACT []
synonym: "urethral inflammation" EXACT []
is_a: MP:0011762 ! renal/urinary system inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T10:58:40Z

[Term]
id: MP:0011764
name: ureteritis
def: "local accumulation of fluid, plasma proteins, and leukocytes in a ureter, usually caused by infection or by the mechanic irritation of a stone; the epithelial reaction may be cystic if the reaction is liquefaction, or glandular if the epithelial reaction is by metaplasia" [https://orcid.org/0000-0002-6490-7723]
synonym: "ureter inflammation" EXACT []
synonym: "ureteral inflammation" EXACT []
synonym: "ureteric inflammation" EXACT []
is_a: MP:0011762 ! renal/urinary system inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T10:58:40Z

[Term]
id: MP:0011765
name: oroticaciduria
def: "increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine orotic acid level" EXACT []
synonym: "orotic aciduria" EXACT []
is_a: MP:0010028 ! aciduria
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T12:53:53Z

[Term]
id: MP:0011766
name: abnormal urinary bladder mucosa morphology
def: "any structural anomaly of the mucous membrane lining the urinary bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal tunica mucosa vesicae urinariae" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T01:08:25Z

[Term]
id: MP:0011767
name: ureterocele
def: "saccular dilation of the terminal portion of the ureter that protrudes into the lumen of the urinary bladder, probably due to a congenital stenosis of the ureteric orifice meatus; most often associated with a duplicated collection system, where two ureters drain their respective kidney instead of one" [https://orcid.org/0000-0002-6490-7723]
synonym: "ureterocoele" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T01:30:31Z

[Term]
id: MP:0011768
name: abnormal urinary bladder trigone morphology
def: "any structural anomaly of the smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal trigone of urinary bladder" EXACT []
synonym: "abnormal vesical trigone morphology" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T01:35:50Z

[Term]
id: MP:0011769
name: urinary bladder fibrosis
def: "invasion of fibrous connective tissue into the urinary bladder, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T01:37:40Z

[Term]
id: MP:0011770
name: increased urine selenium level
def: "greater than normal amount of selenium in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urinary selenium excretion" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:08:10Z

[Term]
id: MP:0011771
name: abnormal genital tubercle morphology
def: "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal phallic tubercle morphology" EXACT []
is_a: MP:0003936 ! abnormal reproductive system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:14:18Z

[Term]
id: MP:0011772
name: genital tubercle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the genital tubercle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic genital tubercle" EXACT []
synonym: "phallic tubercle hypoplasia" EXACT []
is_a: MP:0011771 ! abnormal genital tubercle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:15:21Z

[Term]
id: MP:0011773
name: abnormal urinary bladder vasculature morphology
def: "any structural anomaly of the network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urinary bladder blood vessel morphology" EXACT []
synonym: "abnormal vesical vasculature" EXACT []
synonym: "bladder vasculature abnormalities" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0001614 ! abnormal blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:37:24Z

[Term]
id: MP:0011774
name: abnormal urinary bladder detrusor smooth muscle morphology
def: "any structural anomaly of the bundles of smooth muscle fibers forming the muscular wall of the urinary bladder, which are arranged in a longitudinal and a circular layer and, on contraction, serve to expel urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal detrusor muscle morphology" EXACT []
synonym: "abnormal detrusor urinae morphology" EXACT []
synonym: "abnormal musculus detrusor vesicae" EXACT []
synonym: "abnormal urinary bladder smooth muscle morphology" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0000767 ! abnormal smooth muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:41:16Z

[Term]
id: MP:0011775
name: rectal atresia
def: "congenital absence, closure, or constriction of the lumen of the terminal portion of the intestinal tube adjacent to the anus, leading to abdominal distention after birth" [https://orcid.org/0000-0002-6490-7723]
synonym: "atresia recti" EXACT []
synonym: "imperforate rectum" EXACT []
synonym: "rectum atresia" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-01T02:53:34Z

[Term]
id: MP:0011776
name: abnormal male urethra morphology
def: "any structural anomaly of the male fibromuscular tubular canal which extends from the internal urethral orifice in the urinary bladder to the external urethral orifice at the tip of the penis and provides an exit for urine as well as semen during ejaculation; the male urethra is longer than the urethra of females and comprises three major portions, the (i) prostatic, (ii) membranous (aka intermediate), and (iii) cavernous (aka spongy or penile)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urethra masculina morphology" EXACT []
synonym: "abnormal urethra virilis morphology" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:41:24Z

[Term]
id: MP:0011777
name: abnormal male prostatic urethra morphology
def: "any structural anomaly of the widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pars prostatica urethrae morphology" EXACT []
synonym: "abnormal prostatic part of male urethra" EXACT []
is_a: MP:0011776 ! abnormal male urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:41:24Z

[Term]
id: MP:0011778
name: abnormal male membranous urethra morphology
def: "any structural anomaly of the shortest, least dilatable, and, with the exception of the external orifice, the narrowest part of the male urethral canal located in the deep perineal pouch and lined by pseudostratified columnar epithelium; it extends downward and forward, with a slight anterior concavity, between the apex of the prostate and the bulb of the urethra, perforating the urogenital diaphragm below and behind the pubic symphysis; the membranous portion of the urethra is completely surrounded by the fibers of the sphincter urethrae membranaceae; on either side near its termination are the bulbourethral glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intermediate part of male urethra" EXACT []
synonym: "abnormal pars intermedia urethrae morphology" EXACT []
synonym: "abnormal pars membranacea urethrae morphology" EXACT []
is_a: MP:0011776 ! abnormal male urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:41:24Z

[Term]
id: MP:0011779
name: abnormal male spongy urethra morphology
def: "any structural anomaly of the that longest part of the male urethra contained in the corpus spongiosum and extending from the end of the membranous portion to the external urethral orifice; commencing below the inferior fascia of the urogenital diaphragm it passes forward and upward to the front of the symphysis pubis; and then, in the flaccid condition of the penis, it bends downward and forward; while narrow and of uniform size in the body of the penis, it is dilated behind, within the bulb, and again anteriorly within the glans penis, where it forms the fossa navicularis urethrae; the spongy urethra is lined by pseudostratified columnar epithelium proximally, and by stratified squamous epithelium distally" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cavernous portion of male urethra" EXACT []
synonym: "abnormal pars cavernosa urethrae morphology" EXACT []
synonym: "abnormal pars spongiosa urethrae masculinae morphology" EXACT []
synonym: "abnormal penile urethra morphology" EXACT []
synonym: "abnormal spongiose urethra morphology" EXACT []
is_a: MP:0011776 ! abnormal male urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:41:24Z

[Term]
id: MP:0011780
name: abnormal female urethra morphology
def: "any structural anomaly of the short and relatively simple female fibromuscular tubular canal which extends from the urinary bladder outlet to the perineum adjacent to the anterior wall of the vagina, and opens in the vestibule of the vagina posterior to the clitoris and anterior to the vaginal orifice; small mucus urethral glands (Skene's glands) open along its entire length and drain into a single paraurethral duct, which empties at the lateral margin of the external urethral orifice: its epithelial lining changes from transitional epithelium at the bladder end to non-keratinizing stratified squamous epithelium distally" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urethra feminina morphology" EXACT []
synonym: "abnormal urethra muliebris morphology" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:41:24Z

[Term]
id: MP:0011781
name: abnormal bulbourethral gland physiology
def: "any functional anomaly of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, which produce a clear, salty, viscous secretion known as pre-ejaculate (aka as pre-ejaculatory fluid, preseminal fluid, or Cowper's fluid) upon sexual stimulation; this fluid is believed to lubricate the urethra for spermatozoa to pass through and neutralize traces of acidic urine in the urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bulbo-urethral gland physiology" EXACT []
synonym: "abnormal Cowper's gland physiology" EXACT []
synonym: "abnormal glandula bulbourethralis physiology" EXACT []
synonym: "abnormal Mery gland physiology" EXACT []
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0013327 ! abnormal male reproductive gland physiology
is_a: MP:0013559 ! abnormal exocrine gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T02:53:25Z

[Term]
id: MP:0011782
name: abnormal internal urethral orifice morphology
def: "any structural anomaly of the usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal urethral ostium morphology" EXACT []
synonym: "abnormal internal urinary meatus morphology" EXACT []
synonym: "abnormal orificium urethrae internum morphology" EXACT []
synonym: "abnormal ostium urethrae internum morphology" EXACT []
synonym: "abnormal urethral opening morphology" EXACT []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:00:31Z

[Term]
id: MP:0011783
name: abnormal ureteral orifice morphology
def: "any structural anomaly of the slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal orificium ureteris morphology" EXACT []
synonym: "abnormal ostium ureteris morphology" EXACT []
synonym: "abnormal ureteral meatus morphology" EXACT []
synonym: "abnormal ureteral opening morphology" EXACT []
synonym: "abnormal ureteric orifice morphology" EXACT []
synonym: "abnormal ureterovesical orifice morphology" EXACT []
is_a: MP:0011488 ! abnormal ureterovesical junction morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:05:54Z

[Term]
id: MP:0011784
name: abnormal urinary bladder neck morphology
def: "any structural anomaly of the constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cervix vesicae morphology" EXACT []
synonym: "abnormal collum vesicae morphology" EXACT []
synonym: "abnormal vesical neck morphology" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:09:34Z

[Term]
id: MP:0011785
name: abnormal urinary bladder fundus morphology
def: "any structural anomaly of the base or posterior surface of the urinary bladder, which contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fundus vesicae morphology" EXACT []
synonym: "abnormal urinary bladder base morphology" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:11:19Z

[Term]
id: MP:0011786
name: rectourethral fistula
def: "an abnormal anatomical passage connecting the urethra and the rectum" [https://orcid.org/0000-0002-6490-7723]
synonym: "recto-urethral fistula" EXACT []
synonym: "urethro-rectal fistula" EXACT []
synonym: "urethrorectal fistula" EXACT []
is_a: MP:0000492 ! abnormal rectum morphology
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:13:52Z

[Term]
id: MP:0011787
name: abnormal Bartholin's gland morphology
def: "any structural anomaly of the paired glands located slightly posterior and to the left and right of the opening of the vagina in the superficial perineal pouch in females; they secrete mucus to lubricate the vagina and are homologous to bulbourethral (Cowper's) glands in males" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Bartholin gland morphology" EXACT []
synonym: "abnormal Duverney gland morphology" EXACT []
synonym: "abnormal glandula vestibularis major morphology" EXACT []
synonym: "abnormal greater vestibular gland morphology" EXACT []
synonym: "abnormal major vestibular gland morphology" EXACT []
synonym: "abnormal Tiedemann's gland morphology" EXACT []
synonym: "abnormal vulvovaginal gland morphology" EXACT []
is_a: MP:0009209 ! abnormal internal female genitalia morphology
is_a: MP:0013324 ! abnormal female reproductive gland morphology
is_a: MP:0014032 ! abnormal mucous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:44:43Z

[Term]
id: MP:0011788
name: absent urethra
def: "absence or failure to form of any part of the male or female urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "urethral agenesis" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:48:21Z

[Term]
id: MP:0011789
name: increased urethra carcinoma incidence
def: "greater than the expected number of malignant neoplasms arising from the epithelial lining of the urethra in a given population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urethral carcinoma incidence" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
is_a: MP:0010289 ! increased urinary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:50:50Z

[Term]
id: MP:0011790
name: increased urethral gland adenocarcinoma incidence
def: "greater than the expected number of malignant neoplasms arising from urothelial lining or surrounding glands of the urethra in a given population in a given time period" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010289 ! increased urinary system tumor incidence
is_a: MP:0011792 ! abnormal urethral gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:50:50Z

[Term]
id: MP:0011791
name: increased bulbourethral gland adenocarcinoma incidence
def: "greater than the expected number of malignant neoplasm of epithelial cells in the bulbourethral glands, usually with a glandular organization in a given population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased adenocarcinoma of Cowper's gland incidence" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology
is_a: MP:0010288 ! increased gland tumor incidence
is_a: MP:0010289 ! increased urinary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T03:50:50Z

[Term]
id: MP:0011792
name: abnormal urethral gland morphology
def: "any structural anomaly of any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000537 ! abnormal urethra morphology
is_a: MP:0014032 ! abnormal mucous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:00:10Z

[Term]
id: MP:0011793
name: abnormal female urethral gland morphology
def: "any structural anomaly of the numerous mucous-secreting glands found in several female mammalian species (including rodents and humans) on the anterior wall of the vagina, around the lower end of the urethra, and possessing a common paraurethral duct which opens (on each side) near the external urethral orifice; they are homologous with the prostate gland in males, have highly variable anatomy, and are believed to be the source of the female ejaculate, a lubricating fluid with a similar consistency to male prostatic fluid that is expelled through the urethra during sexual stimulation; like the male prostate, these glands are susceptible to infection (skenitis), cyst development, and cancer" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal female prostate morphology" EXACT []
synonym: "abnormal glands of the female urethra" BROAD []
synonym: "abnormal glandula vestibulares minor morphology" EXACT []
synonym: "abnormal glandulae urethrales femininae" BROAD []
synonym: "abnormal Guerin gland morphology" EXACT []
synonym: "abnormal lesser vestibular gland morphology" EXACT []
synonym: "abnormal para-urethral gland morphology" EXACT []
synonym: "abnormal paraurethral gland morphology" EXACT []
synonym: "abnormal periurethral gland morphology" EXACT []
synonym: "abnormal Schueller's gland morphology" EXACT []
synonym: "abnormal Skene gland morphology" EXACT []
synonym: "abnormal Skene's gland morphology" EXACT []
synonym: "abnormal U-spot morphology" EXACT []
is_a: MP:0011792 ! abnormal urethral gland morphology
is_a: MP:0013324 ! abnormal female reproductive gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:00:52Z

[Term]
id: MP:0011794
name: abnormal male urethral gland morphology
def: "any structural anomaly of any of the numerous small mucous-secreting glands located in the wall of the penile urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glands of the male urethra" BROAD []
synonym: "abnormal glandulae urethrales masculinae" EXACT []
synonym: "abnormal Littre glands morphology" EXACT []
is_a: MP:0011792 ! abnormal urethral gland morphology
is_a: MP:0013325 ! abnormal male reproductive gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:00:52Z

[Term]
id: MP:0011795
name: abnormal urinary bladder development
def: "incomplete or aberrant differentiation of the distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cystis urinaria development" EXACT []
synonym: "abnormal urocyst development" EXACT []
synonym: "abnormal urocystis development" EXACT []
synonym: "abnormal vesica development" EXACT []
synonym: "abnormal vesica urinaria development" EXACT []
synonym: "urinary bladder dysgenesis" EXACT []
synonym: "urinary bladder malformation" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0003942 ! abnormal urinary system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:04:12Z

[Term]
id: MP:0011796
name: abnormal external urethral orifice morphology
def: "any structural anomaly of the external opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located either within the clitoris or between the clitoris and the vagina in the vulvular vestibule of the female genitalia, depending on the species" [EMAPA:36453]
synonym: "abnormal external urethral ostium morphology" EXACT []
synonym: "abnormal external urinary meatus morphology" EXACT []
synonym: "abnormal meatus urinarius morphology" EXACT []
synonym: "abnormal orificium urethrae externum morphology" EXACT []
synonym: "abnormal ostium urethrae externum morphology" EXACT []
synonym: "abnormal urinary meatus morphology" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:12:05Z

[Term]
id: MP:0011797
name: blind ureter
def: "a ureter ending in a blind-ended segment or pouch" [https://orcid.org/0000-0002-6490-7723]
synonym: "blind-ended ureter" EXACT []
synonym: "blind-ending ureter" EXACT []
is_a: MP:0000534 ! abnormal ureter morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:19:31Z

[Term]
id: MP:0011798
name: abnormal urinary bladder weight
def: "anomaly in the average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000538 ! abnormal urinary bladder morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:20:49Z

[Term]
id: MP:0011799
name: increased urinary bladder weight
def: "greater than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011798 ! abnormal urinary bladder weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:21:19Z

[Term]
id: MP:0011800
name: decreased urinary bladder weight
def: "less than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urinary bladder weight" EXACT []
is_a: MP:0011798 ! abnormal urinary bladder weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:21:40Z

[Term]
id: MP:0011801
name: urethra obstruction
def: "any impediment or blockage of the canal through which urine is discharged from the bladder in most mammals and through which semen is discharged in the male; usually caused by calculus, or plugs composed of proteinaceous material, cellular debris and possibly crystals" [https://orcid.org/0000-0002-6490-7723]
synonym: "urethral obstruction" EXACT []
synonym: "urethral plug" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:23:17Z

[Term]
id: MP:0011802
name: seminal vesiculitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the seminal vesicle(s), usually caused by an infection" [https://orcid.org/0000-0002-6490-7723]
synonym: "gonecystitis" EXACT []
synonym: "inflamed seminal gland" EXACT []
synonym: "inflamed seminal glands" EXACT []
synonym: "inflamed seminal vesicle" EXACT []
synonym: "inflamed seminal vesicles" EXACT []
synonym: "seminal gland inflammation" EXACT []
synonym: "seminal vesicle inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0013902 ! abnormal seminal vesicle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:26:55Z

[Term]
id: MP:0011803
name: double kidney pelvis
def: "duplication of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [https://orcid.org/0000-0002-6490-7723]
synonym: "double pyelum" EXACT []
synonym: "double renal pelvis" EXACT []
synonym: "duplex pyelum" EXACT []
synonym: "duplicated pyelum" EXACT []
synonym: "duplication of renal pelvis" EXACT []
is_a: MP:0004194 ! abnormal kidney pelvis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-15T04:29:19Z

[Term]
id: MP:0011804
name: increased cell migration
def: "increased or faster movement of cells from one site to another, often occurring during developmental or chemotactic processes" [GO:0016477, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003091 ! abnormal cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:14:05Z

[Term]
id: MP:0011805
name: decreased cell migration
def: "reduced or slower movement of cells from one site to another, often occurring during developmental or chemotactic processes" [GO:0016477, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cell migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:14:05Z

[Term]
id: MP:0011806
name: decreased dermal fibroblast proliferation
def: "reduction in the expansion rate of a dermal fibroblast cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011704 ! decreased fibroblast proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:19:09Z

[Term]
id: MP:0011807
name: decreased lung fibroblast proliferation
def: "reduction in the expansion rate of a lung fibroblast cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011704 ! decreased fibroblast proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:20:12Z

[Term]
id: MP:0011808
name: abnormal myoblast differentiation
def: "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0045445]
synonym: "abnormal myoblast cell differentiation" EXACT []
is_a: MP:0000729 ! abnormal myogenesis
is_a: MP:0005076 ! abnormal cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:23:14Z

[Term]
id: MP:0011809
name: abnormal anoikis
def: "anomaly in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix" [GO:0043276]
synonym: "abnormal detachment induced cell death" EXACT []
synonym: "abnormal suspension induced apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:50:45Z

[Term]
id: MP:0011810
name: increased anoikis
def: "increase in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix" [GO:0043276]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0011809 ! abnormal anoikis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:53:17Z

[Term]
id: MP:0011811
name: decreased anoikis
def: "reduction in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix" [GO:0043276]
synonym: "reduced anoikis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0011809 ! abnormal anoikis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T10:53:17Z

[Term]
id: MP:0011812
name: increased cranium length
def: "having an increased dorsal-to-ventral distance of the cranium" [MGI:mberry]
is_a: MP:0010031 ! abnormal cranium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:14:30Z

[Term]
id: MP:0011813
name: long maxilla
def: "increased length of the upper jaw bone" [MGI:mberry]
synonym: "increased maxilla length" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:16:36Z

[Term]
id: MP:0011814
name: abnormal pre-pro B cell morphology
def: "any structural anomaly of a pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045]
synonym: "abnormal Fraction A pre-pro B cell morphology" EXACT []
is_a: MP:0005432 ! abnormal pro-B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:46:55Z

[Term]
id: MP:0011815
name: increased pre-pro B cell number
def: "increased number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008186 ! increased pro-B cell number
is_a: MP:0011814 ! abnormal pre-pro B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:50:14Z

[Term]
id: MP:0011816
name: decreased pre-pro B cell number
def: "reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, https://orcid.org/0000-0003-3691-0324]
synonym: "reduced pre-pro B cell number" EXACT []
is_a: MP:0008208 ! decreased pro-B cell number
is_a: MP:0011814 ! abnormal pre-pro B cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:50:14Z

[Term]
id: MP:0011817
name: absent pre-pro B cells
def: "absence of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011816 ! decreased pre-pro B cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T12:50:24Z

[Term]
id: MP:0011818
name: abnormal pancreatic beta cell proliferation
def: "anomaly in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0003562 ! abnormal pancreatic beta cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:18:26Z

[Term]
id: MP:0011819
name: increased pancreatic beta cell proliferation
def: "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011818 ! abnormal pancreatic beta cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:25:35Z

[Term]
id: MP:0011820
name: decreased pancreatic beta cell proliferation
def: "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
synonym: "reduced pancreatic beta cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011818 ! abnormal pancreatic beta cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:25:35Z

[Term]
id: MP:0011821
name: abnormal CD8-positive, alpha-beta memory T cell proliferation
def: "anomaly in the ability of the CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0008051 ! abnormal memory T cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:34:52Z

[Term]
id: MP:0011822
name: increased CD8-positive, alpha-beta memory T cell proliferation
def: "increase in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011821 ! abnormal CD8-positive, alpha-beta memory T cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:36:08Z

[Term]
id: MP:0011823
name: decreased CD8-positive, alpha-beta memory T cell proliferation
def: "reduction in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
synonym: "reduced CD8-positive, alpha-beta memory T cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011821 ! abnormal CD8-positive, alpha-beta memory T cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:36:08Z

[Term]
id: MP:0011824
name: increased cell chemotaxis
def: "increase in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011518 ! abnormal cell chemotaxis
is_a: MP:0011804 ! increased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:44:31Z

[Term]
id: MP:0011825
name: decreased cell chemotaxis
def: "reduction in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cell chemotaxis" EXACT []
is_a: MP:0011518 ! abnormal cell chemotaxis
is_a: MP:0011805 ! decreased cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:44:49Z

[Term]
id: MP:0011826
name: abnormal lymphocyte chemotaxis
def: "any anomaly in the directed movement of a lymphocyte in response to an external stimulus" [GO:0048247]
is_a: MP:0003156 ! abnormal leukocyte migration
is_a: MP:0011518 ! abnormal cell chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:51:42Z

[Term]
id: MP:0011827
name: impaired neuron differentiation
def: "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009937 ! abnormal neuron differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T01:56:36Z

[Term]
id: MP:0011828
name: urinary bladder cyst
def: "presence of one or more abnormal membranous sacs, usually filled with a fluid or viscous substance, along the internal lining of the urinary bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "bladder cyst" EXACT []
synonym: "bladder cysts" EXACT []
synonym: "cystic bladder" EXACT []
synonym: "cystic urinary bladder" EXACT []
synonym: "urinary bladder cysts" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0031310 ! abnormal cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T02:56:30Z

[Term]
id: MP:0011829
name: vesicovaginal fistula
def: "an abnormal fistulous tract extending between the bladder and the vagina, with resulting leakage of urine into the vaginal cavity" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0001139 ! abnormal vagina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T03:00:44Z

[Term]
id: MP:0011830
name: ectopic hair follicle melanin granules
def: "any aberration in normal location of pigment granules in the hair follicle that results in variation from expected hair color" [MGI:llw2]
is_a: MP:0005072 ! abnormal hair follicle melanin granule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T03:04:36Z

[Term]
id: MP:0011831
name: abnormal visual contrast sensitivity
def: "any abnormality in the ability to distinguish between increments of light versus dark" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002090 ! abnormal vision
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T03:50:13Z

[Term]
id: MP:0011832
name: abnormal visual acuity
def: "any abnormality in the spatial resolution or resolving power of the visual processing system" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal clarity of vision" EXACT []
synonym: "abnormal sharpness of vision" EXACT []
is_a: MP:0002090 ! abnormal vision
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-16T03:51:48Z

[Term]
id: MP:0011833
name: abnormal cremaster muscle morphology
def: "any structural anomaly of the thin layer of skeletal muscle that envelops the spermatic cord and testis of most male mammals in a series of loops; it is a continuation of the obliquus internus, arising from the inguinal ligament and inserting into the crest of the pubis and into the sheath of the rectus abdominis; it is innervated by the genital branch of the genitofemoral nerve and functions to draw the testis up toward the superficial inguinal ring in response to cold or to stimulation of the nerve; in females it is represented by only a few muscle loops that envelop the round ligament of the uterus" [https://orcid.org/0000-0002-6490-7723]
comment: In rats, it has been shown that cremaster muscles develop from the gubernacular bulb.
synonym: "abnormal cremaster morphology" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T02:55:12Z

[Term]
id: MP:0011834
name: abnormal female preputial gland morphology
def: "any structural anomaly of the paired, lobulated, modified sebaceous glands located on the side of the clitoris in female rodents; in contrast to the preputial glands in male rodents, clitoral glands are a minor source of olfactory stimuli contributing to sexual attractivity; unlike other sebaceous glands, they undergo progressive atrophy of the glandular portion with marked ductal ectasia as rodents age; there is no true anatomical equivalent in humans" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal clitoral gland morphology" EXACT []
is_a: MP:0013324 ! abnormal female reproductive gland morphology
is_a: MP:0013329 ! abnormal preputial gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T02:58:33Z

[Term]
id: MP:0011835
name: abnormal urogenital fold morphology
def: "any structural anomaly of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urethral fold morphology" EXACT []
synonym: "abnormal urogenital ridge morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:18:00Z

[Term]
id: MP:0011836
name: abnormal cloacal fold morphology
def: "any structural anomaly of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010115 ! abnormal embryonic cloaca morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:20:12Z

[Term]
id: MP:0011837
name: abnormal cloacal membrane morphology
def: "any structural anomaly of the membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal membrana cloacalis morphology" RELATED []
is_a: MP:0010115 ! abnormal embryonic cloaca morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:21:45Z

[Term]
id: MP:0011838
name: abnormal navicular fossa morphology
def: "any structural anomaly of the dilated terminal portion of the male spongy urethra located in the glans penis right before the external urethral orifice, also referred to as the most distal pendulous urethra; it is lined by stratified squamous, non-keratinizing epithelium; during development, the glans of the penis is initially solid but cannulates to give rise to the navicular fossa" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fossa navicularis urethrae morphology" EXACT []
synonym: "abnormal navicular fossa of male urethra" EXACT []
is_a: MP:0011779 ! abnormal male spongy urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:32:00Z

[Term]
id: MP:0011839
name: abnormal Guerin's valve morphology
def: "any structural anomaly of the fold or valve of mucus membrane on the upper wall of the navicuar fossa" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Guerin's valvule morphology" EXACT []
synonym: "abnormal urethral valve of Guerin" EXACT []
synonym: "abnormal valvula fossae navicularis" EXACT []
is_a: MP:0011838 ! abnormal navicular fossa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:33:07Z

[Term]
id: MP:0011840
name: abnormal urethral crest morphology
def: "any structural anomaly of the longitudinal mucosal fold in the dorsal wall of the urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal crista urethralis morphology" EXACT []
is_a: MP:0000537 ! abnormal urethra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:36:23Z

[Term]
id: MP:0011841
name: abnormal male urethral crest morphology
def: "any structural anomaly of the narrow longitudinal fold of mucosa on the posterior wall of the male urethra, extending from the uvula of the bladder through the prostatic urethra; when distended, it may serve to prevent the passage of the semen backward into the bladder; on either side of the male urethral crest is a slightly depressed fossa, the prostatic sinus, the floor of which is perforated by the orifices of the prostatic ducts from the lateral lobes of the prostate; the ducts of the middle lobe open behind the crest; at the forepart of the crest, below its summit, is a median elevation, the colliculus seminalis, upon or within the margins of which are the orifices of the prostatic utricle and the slit-like openings of the ejaculatory ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal crista phallica morphology" EXACT []
synonym: "abnormal crista urethralis masculinae morphology" EXACT []
synonym: "abnormal urethral crest of male" EXACT []
is_a: MP:0011776 ! abnormal male urethra morphology
is_a: MP:0011840 ! abnormal urethral crest morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:36:23Z

[Term]
id: MP:0011842
name: abnormal female urethral crest morphology
def: "any structural anomaly of the conspicuous longitudinal fold of mucosa on the posterior wall of the female urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal crista urethralis femininae morphology" EXACT []
synonym: "abnormal urethral crest of female" EXACT []
is_a: MP:0011780 ! abnormal female urethra morphology
is_a: MP:0011840 ! abnormal urethral crest morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:36:23Z

[Term]
id: MP:0011843
name: abnormal kidney collecting duct epithelium morphology
def: "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004754 ! abnormal kidney collecting duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:40:18Z

[Term]
id: MP:0011844
name: kidney collecting duct atrophy
def: "acquired diminution of the size of the kidney collecting ducts associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004754 ! abnormal kidney collecting duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:43:16Z

[Term]
id: MP:0011845
name: abnormal kidney collecting duct number
def: "anomaly in the number of any of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004754 ! abnormal kidney collecting duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:43:16Z

[Term]
id: MP:0011846
name: decreased kidney collecting duct number
def: "smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011845 ! abnormal kidney collecting duct number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:43:16Z

[Term]
id: MP:0011847
name: increased kidney collecting duct number
def: "larger than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011845 ! abnormal kidney collecting duct number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:43:16Z

[Term]
id: MP:0011848
name: abnormal vagina vestibule morphology
def: "any structural anomaly of the space posterior to the glans clitoridis, between the labia minora; located within the vestibule are the openings of the vagina, the urethra, and the ducts of the lesser vestibular glands, the greater vestibular (Bartholin's) glands, and the paraurethral (Skene's) glands, which release mucus into the vestibule to maintain a moist, lubricated vestibular environment; the vestibule is also moistened by secretions from the cervical mucus glands located in the inferior region of the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vaginal vestibule morphology" EXACT []
synonym: "abnormal vestibule of vagina" EXACT []
synonym: "abnormal vestibulum pudendi" EXACT []
synonym: "abnormal vestibulum vaginae" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-11-30T03:51:49Z

[Term]
id: MP:0011849
name: abnormal clitoral bone morphology
def: "any structural anomaly of the ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans;it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal baubellum morphology" EXACT []
synonym: "abnormal os clitoridis morphology" EXACT []
synonym: "abnormal os clitoris morphology" EXACT []
is_a: MP:0003127 ! abnormal clitoris morphology
is_a: MP:0005508 ! abnormal skeleton morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T03:21:34Z

[Term]
id: MP:0011850
name: absent clitoral bone
def: "absence of the unique bone located in the clitoris of most mammals except humans" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent baubellum" EXACT []
synonym: "absent os clitoridis" EXACT []
synonym: "absent os clitoris" EXACT []
is_a: MP:0011849 ! abnormal clitoral bone morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T03:21:34Z

[Term]
id: MP:0011851
name: abnormal embryonic cloaca development
def: "failure or anomaly in the formation of a pouch-like dilation of the caudal end of the hindgut by the process of folding of the caudal region of the embryonic disk; during the tail-fold process, the posteriorly placed allantois, or allantoic diverticulum of the yolk sac, becomes an anterior extension of the cloaca; soon after the cloaca forms, it receives posterolaterally the caudal ends of the paired mesonephric ducts and hence becomes a junctional cistern for the allantois, the hindgut, and the ducts; a cloacal membrane, composed of ectoderm and endoderm, is the caudal limit of the primitive gut and temporarily separates the cloacal cavity from the extraembryonic confines of the amniotic cavity; subsequent growth of the urorectal septum eventually subdivides the once single cloaca chamber into the primitive urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010115 ! abnormal embryonic cloaca morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T03:36:14Z

[Term]
id: MP:0011852
name: patent urachus
def: "failure of complete urachal lumen closure resulting in an open channel between the urinary bladder and the umbilicus and leakage of urine through the umbilicus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003616 ! abnormal urachus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T03:53:07Z

[Term]
id: MP:0011853
name: abnormal urorectal septum morphology
def: "any structural anomaly of the ridge of mesoderm covered with endoderm that in the early developing embryo partitions the endodermal cloaca into the primary urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally); the urorectal septum eventually fuses with the cloacal membrane, dividing it into a dorsal anal membrane and a larger ventral urogenital membrane - this area of fusion is represented in the adult by the perineal body" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cloacal septum morphology" EXACT []
synonym: "abnormal septum urorectale morphology" EXACT []
synonym: "abnormal urorectal fold morphology" EXACT []
synonym: "abnormal urorectal membrane morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T03:56:42Z

[Term]
id: MP:0011854
name: cerebral edema
def: "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "brain edema" EXACT []
synonym: "brain oedema" EXACT []
synonym: "brain swelling" EXACT []
synonym: "cerebral oedema" EXACT []
synonym: "swelling of the brain" EXACT []
synonym: "wet brain" EXACT []
is_a: MP:0001785 ! edema
is_a: MP:0002152 ! abnormal brain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:01:47Z

[Term]
id: MP:0011855
name: abnormal glomerular filtration barrier morphology
def: "any structural anomaly of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte)" [https://orcid.org/0000-0002-6490-7723, PMCID:PMC2895306]
synonym: "abnormal GFB morphology" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:05:39Z

[Term]
id: MP:0011856
name: abnormal glomerular filtration barrier function
def: "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [https://orcid.org/0000-0002-6490-7723, PMCID:PMC2895306]
synonym: "abnormal GFB permeability" EXACT []
is_a: MP:0013284 ! abnormal renal glomerular filtration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:12:41Z

[Term]
id: MP:0011857
name: short kidney papilla
def: "reduced average length of the apex of the renal pyramid that projects into a calyx" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced length of kidney papilla" EXACT []
synonym: "reduced renal papillary length" EXACT []
synonym: "short renal papilla" EXACT []
synonym: "shortened kidney papilla" EXACT []
is_a: MP:0004193 ! abnormal kidney papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:16:45Z

[Term]
id: MP:0011858
name: elongated kidney papilla
def: "increased average length of the apex of the renal pyramid that projects into a calyx" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased renal papillary length" EXACT []
synonym: "overextended kidney papilla" EXACT []
synonym: "overextended renal papilla" EXACT []
synonym: "overgrown papilla" EXACT []
synonym: "overgrowth of renal papilla" EXACT []
is_a: MP:0004193 ! abnormal kidney papilla morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:16:45Z

[Term]
id: MP:0011859
name: decreased renal glomerulus basement membrane thickness
def: "reduced width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [https://orcid.org/0000-0002-6490-7723]
synonym: "GBM thinning" EXACT []
synonym: "reduced GBM width" EXACT []
synonym: "thin renal glomerulus basement membrane" EXACT []
synonym: "thinned renal glomerulus basement membrane" EXACT []
is_a: MP:0011349 ! abnormal renal glomerulus basement membrane thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:20:10Z

[Term]
id: MP:0011860
name: abnormal peritubular capillary endothelium morphology
def: "any structural anomaly of the thin sheet of endothelial cells along the basal lamina of renal tubular cells characterized by their attenuated shape and numerous regularly-spaced transcellular pores (aka fenestrae or fenestrations); the fenestrae of peritubular capillaries differ from the fenestrae of glomerular capillaries in that they are much smaller and possess a small overlying diaphragm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009489 ! abnormal blood vessel endothelium morphology
is_a: MP:0011321 ! abnormal peritubular capillary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:22:13Z

[Term]
id: MP:0011861
name: increased cranium height
def: "increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull" [https://orcid.org/0000-0003-0431-8641]
is_a: MP:0010031 ! abnormal cranium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:25:18Z

[Term]
id: MP:0011862
name: decreased cranium length
def: "having a decreased dorsal-to-ventral distance of the cranium" [https://orcid.org/0000-0003-0431-8641]
is_a: MP:0010031 ! abnormal cranium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-17T04:25:18Z

[Term]
id: MP:0011863
name: abnormal podocyte physiology
def: "any functional anomaly of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
is_a: MP:0002136 ! abnormal kidney physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-20T03:49:19Z

[Term]
id: MP:0011864
name: abnormal podocyte adhesion
def: "any anomaly in the adhesive properties of glomerular podocytes, resulting in abnormal cell to cell and cell to extracellular matrix (ECM) interactions; podocytes adhere tightly to ECM components of the glomerular basement membrane via an integrin-laminin-actin axis to maintain a functional filtration barrier in the presence of mechanical stress" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal podocyte adherence" EXACT []
synonym: "abnormal podocyte-ECM adhesion" EXACT []
is_a: MP:0003566 ! abnormal cell adhesion
is_a: MP:0011863 ! abnormal podocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-20T03:51:30Z

[Term]
id: MP:0011865
name: abnormal podocyte motility
def: "any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal podocyte foot process motility" NARROW []
synonym: "abnormal podocyte migration" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0011863 ! abnormal podocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-20T03:53:30Z

[Term]
id: MP:0011866
name: increased podocyte motility
def: "greater ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM)" [https://orcid.org/0000-0002-6490-7723]
comment: Increased podocyte motility is believed to promote the development of FP effacement and proteinuria.
synonym: "podocyte hypermotility" EXACT []
is_a: MP:0011804 ! increased cell migration
is_a: MP:0011865 ! abnormal podocyte motility
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-20T03:54:46Z

[Term]
id: MP:0011867
name: decreased podocyte motility
def: "reduced ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM)" [https://orcid.org/0000-0002-6490-7723]
comment: Decreased podocyte motility is believed to stabilize the podocyte FP architecture and protect from effacement and proteinuria.
synonym: "podocyte hypomotility" EXACT []
synonym: "reduced podocyte motility" EXACT []
is_a: MP:0011805 ! decreased cell migration
is_a: MP:0011865 ! abnormal podocyte motility
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-20T03:54:46Z

[Term]
id: MP:0011868
name: podocyte microvillus transformation
def: "aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "microvillus transformation of foot processes" EXACT []
synonym: "podocyte microvilli" EXACT []
synonym: "podocyte microvillous transformation" EXACT []
synonym: "podocyte pseudovilli" EXACT []
synonym: "podocyte pseudovillous transformation" EXACT []
synonym: "podocyte pseudovillus transformation" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:23:49Z

[Term]
id: MP:0011869
name: detached podocyte
def: "detachment or loss of adhesion of podocyte foot processes from the glomerular basement membrane (GBM); as a consequence, denuded GBM areas at peripheral capillary loops can become foci for adhesions to parietal epithelial cells (glomerular synechiae) and crescent formation, and podocytes and podocyte-specific proteins may be found in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "detached podocyte foot processes" EXACT []
synonym: "podocyte detachment" EXACT []
synonym: "podocyte foot process detachment" EXACT []
is_a: MP:0011864 ! abnormal podocyte adhesion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:27:09Z

[Term]
id: MP:0011870
name: abnormal podocyte polarity
def: "any anomaly in the establishment or maintenance of podocyte cell polarity; podocytes exhibit polarity along at least two axes: (i) an apical-basal axis perpendicular to the glomerular basement membrane in which the apical and basolateral membrane domains of the podocyte are separated by a boundary created by the intercellular junctions of the foot process and (ii) a second plane parallel to the basement membrane that determines the unique orientation of interdigitating foot processes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005326 ! abnormal podocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:28:56Z

[Term]
id: MP:0011871
name: podocyte hypertrophy
def: "increase in the size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged podocytes" EXACT []
synonym: "glomerular visceral epithelial cell hypertrophy" EXACT []
synonym: "hypertrophic glomerular epithelial cells" EXACT []
synonym: "hypertrophic glomerular visceral epithelial cells" EXACT []
synonym: "hypertrophic podocytes" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:29:59Z

[Term]
id: MP:0011872
name: absent xiphoid process
def: "absence of the caudal tip of the sternum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0000159 ! abnormal xiphoid process morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:45:48Z

[Term]
id: MP:0011873
name: enlarged uterine horn
def: "increased size of the uterine horn" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
synonym: "enlarged metral horn" EXACT []
synonym: "increased uterine horn size" EXACT []
is_a: MP:0009085 ! abnormal uterine horn morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:50:19Z

[Term]
id: MP:0011874
name: enlarged urinary bladder
def: "increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
synonym: "increased urinary bladder size" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0031094 ! organomegaly
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:51:32Z

[Term]
id: MP:0011875
name: absent stomach
def: "absence of the sac-like structure of the digestive canal between the esophagus and the small intestine" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0000470 ! abnormal stomach morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:54:16Z

[Term]
id: MP:0011876
name: absent penis
def: "absence of organ of copulation and urination in the male" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0005187 ! abnormal penis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:56:30Z

[Term]
id: MP:0011877
name: absent liver
def: "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0000598 ! abnormal liver morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:57:54Z

[Term]
id: MP:0011878
name: jejunum atresia
def: "congenital blockage or absence of the lumen of the jejunum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0004002 ! abnormal jejunum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:59:18Z

[Term]
id: MP:0011879
name: ileum atresia
def: "congenital blockage or absence of the lumen of the ileum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
synonym: "ileal atresia" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T03:59:53Z

[Term]
id: MP:0011880
name: absent duodenum
def: "missing portion of the small intestine that extends from the pyloris to the junction with the jejunum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0003271 ! abnormal duodenum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T04:00:21Z

[Term]
id: MP:0011881
name: distended duodenum
def: "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0003271 ! abnormal duodenum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T04:01:38Z

[Term]
id: MP:0011882
name: enlarged duodenum
def: "increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
synonym: "increased duodenum size" EXACT []
is_a: MP:0003271 ! abnormal duodenum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T04:02:07Z

[Term]
id: MP:0011883
name: absent diaphragm
def: "absence of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0002279 ! abnormal diaphragm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T04:03:25Z

[Term]
id: MP:0011884
name: absent colon
def: "absence of the portion of the large intestine between the cecum and the rectum" [https://orcid.org/0000-0002-2232-0967]
subset: IMPC
is_a: MP:0000495 ! abnormal colon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2012-12-21T04:04:14Z

[Term]
id: MP:0011885
name: abnormal circulating lipase level
def: "any anomaly in the concentration of lipase in the blood, in particular the serum; the measurement of serum lipase activity is widely used for the diagnosis of acute pancreatitis" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:38:38Z

[Term]
id: MP:0011886
name: increased circulating lipase level
def: "elevated blood level of lipase in the blood, in particular the serum" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0011885 ! abnormal circulating lipase level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:39:39Z

[Term]
id: MP:0011887
name: decreased circulating lipase level
def: "reduced blood level of lipase in the blood, in particular the serum" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0011885 ! abnormal circulating lipase level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:39:39Z

[Term]
id: MP:0011888
name: abnormal circulating total protein level
def: "total circulating protein concentration is outside the normal range" [RGD:cur]
subset: IMPC
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:43:42Z

[Term]
id: MP:0011889
name: abnormal circulating ferritin level
def: "deviation from the normal concentration of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:48:53Z

[Term]
id: MP:0011890
name: increased circulating ferritin level
def: "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "hyperferritinaemia" EXACT []
synonym: "hyperferritinemia" EXACT []
is_a: MP:0011889 ! abnormal circulating ferritin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:49:53Z

[Term]
id: MP:0011891
name: decreased circulating ferritin level
def: "reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "hypoferritinaemia" EXACT []
synonym: "hypoferritinemia" EXACT []
is_a: MP:0011889 ! abnormal circulating ferritin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:49:53Z

[Term]
id: MP:0011892
name: abnormal circulating transferrin level
def: "deviation from the normal concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:53:05Z

[Term]
id: MP:0011893
name: increased circulating transferrin level
def: "elevated concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0011892 ! abnormal circulating transferrin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:54:01Z

[Term]
id: MP:0011894
name: decreased circulating transferrin level
def: "reduced concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0011892 ! abnormal circulating transferrin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T12:54:01Z

[Term]
id: MP:0011895
name: abnormal circulating unsaturated transferrin level
def: "any anomaly in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal unsaturated iron binding capacity" EXACT []
is_a: MP:0011892 ! abnormal circulating transferrin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T01:52:06Z

[Term]
id: MP:0011896
name: increased circulating unsaturated transferrin level
def: "increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "increased unsaturated iron binding capacity" EXACT []
is_a: MP:0011893 ! increased circulating transferrin level
is_a: MP:0011895 ! abnormal circulating unsaturated transferrin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T01:52:06Z

[Term]
id: MP:0011897
name: decreased circulating unsaturated transferrin level
def: "reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "decreased unsaturated iron binding capacity" RELATED []
is_a: MP:0011894 ! decreased circulating transferrin level
is_a: MP:0011895 ! abnormal circulating unsaturated transferrin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T01:52:06Z

[Term]
id: MP:0011898
name: abnormal platelet cell number
def: "anomaly in the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal thrombocyte cell number" EXACT []
is_a: MP:0004720 ! abnormal platelet morphology
is_a: MP:0011180 ! abnormal hematopoietic cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T02:12:57Z

[Term]
id: MP:0011899
name: podocyte vacuoles
def: "abnormal presence of fluid-filled vesicles in the cytoplasm of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, often indicative of podocyte injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "glomerular epithelial cell vacuolation" EXACT []
synonym: "podocyte vacuolation" EXACT []
synonym: "vacuolated glomerular visceral epithelial cells" BROAD []
synonym: "vacuolated podocytes" EXACT []
synonym: "vacuolized podocytes" EXACT []
is_a: MP:0005326 ! abnormal podocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T03:15:15Z

[Term]
id: MP:0011900
name: podocyturia
def: "presence of kidney podocytes, their cell fragments, or podocyte-specific proteins in the urine; urinary loss of viable podocytes may serve as a diagnostic tool for pre-eclampsia and as a marker of active renal disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "urinary podocyte excretion" EXACT []
synonym: "urinary podocytes" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-05T03:26:54Z

[Term]
id: MP:0011901
name: abnormal hematopoietic stem cell proliferation
def: "anomaly in the ability of a hematopoietic stem cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal haematopoietic progenitor cell proliferation" EXACT []
synonym: "abnormal haematopoietic stem cell proliferation" EXACT []
synonym: "abnormal haemopoietic progenitor cell proliferation" EXACT []
synonym: "abnormal hematopoietic progenitor cell proliferation" EXACT []
synonym: "abnormal hemopoietic progenitor cell proliferation" EXACT []
synonym: "abnormal HSC proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0010763 ! abnormal hematopoietic stem cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T11:55:12Z

[Term]
id: MP:0011902
name: increased hematopoietic stem cell proliferation
def: "increase in the expansion rate of a hematopoietic stem cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased haematopoietic progenitor cell proliferation" EXACT []
synonym: "increased haematopoietic stem cell proliferation" EXACT []
synonym: "increased haemopoietic progenitor cell proliferation" EXACT []
synonym: "increased hematopoietic progenitor cell proliferation" EXACT []
synonym: "increased hemopoietic progenitor cell proliferation" EXACT []
synonym: "increased HSC proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011901 ! abnormal hematopoietic stem cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T11:57:06Z

[Term]
id: MP:0011903
name: decreased hematopoietic stem cell proliferation
def: "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased haematopoietic progenitor cell proliferation" EXACT []
synonym: "decreased haematopoietic stem cell proliferation" EXACT []
synonym: "decreased haemopoietic progenitor cell proliferation" EXACT []
synonym: "decreased hematopoietic progenitor cell proliferation" EXACT []
synonym: "decreased hemopoietic progenitor cell proliferation" EXACT []
synonym: "decreased HSC proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011901 ! abnormal hematopoietic stem cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T11:57:06Z

[Term]
id: MP:0011904
name: abnormal Schwann cell physiology
def: "any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
is_a: MP:0003690 ! abnormal glial cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T12:52:51Z

[Term]
id: MP:0011905
name: abnormal Schwann cell proliferation
def: "any anomaly in the ability of a Schwann cell to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0011904 ! abnormal Schwann cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T12:54:04Z

[Term]
id: MP:0011906
name: increased Schwann cell proliferation
def: "increase in the expansion rate of a Schwann cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011905 ! abnormal Schwann cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T12:54:04Z

[Term]
id: MP:0011907
name: decreased Schwann cell proliferation
def: "reduction in the expansion rate of a Schwann cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "impaired Schwann cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011905 ! abnormal Schwann cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T12:54:04Z

[Term]
id: MP:0011908
name: abnormal pancreatic endocrine progenitor cell proliferation
def: "anomaly in the ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal pancreatic islet progenitor cell proliferation" EXACT []
xref: CL:0002351
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0011911 ! abnormal pancreatic endocrine progenitor cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T14:31:03Z

[Term]
id: MP:0011909
name: increased pancreatic endocrine progenitor cell proliferation
def: "increased ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pancreatic islet progenitor cell proliferation" EXACT []
xref: CL:0002351
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011908 ! abnormal pancreatic endocrine progenitor cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T14:31:56Z

[Term]
id: MP:0011910
name: decreased pancreatic endocrine progenitor cell proliferation
def: "reduced ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased pancreatic islet progenitor cell proliferation" EXACT []
xref: CL:0002351
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011908 ! abnormal pancreatic endocrine progenitor cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T14:31:56Z

[Term]
id: MP:0011911
name: abnormal pancreatic endocrine progenitor cell physiology
def: "any functional anomaly of a multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells" [CL:0002351]
synonym: "abnormal pancreatic islet progenitor cell physiology" EXACT []
xref: CL:0002351
is_a: MP:0010147 ! abnormal endocrine pancreas physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-02-20T15:47:45Z

[Term]
id: MP:0011912
name: abnormal circulating fibronectin level
def: "aberrant concentration in the blood of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development" [MPD:Molly]
synonym: "abnormal plasma fibronectin level" NARROW []
synonym: "abnormal soluble fibronectin level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T11:54:01Z

[Term]
id: MP:0011913
name: abnormal reticulocyte cell number
def: "altered number of immature (nucleated) erythrocytes" [MPD:Molly]
is_a: MP:0002424 ! abnormal reticulocyte morphology
is_a: MP:0013661 ! abnormal myeloid cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:05:06Z

[Term]
id: MP:0011914
name: decreased heart left atrium weight
def: "less than average weight of the left atrium" [MPD:Molly]
synonym: "reduced heart left atrium weight" EXACT []
is_a: MP:0020206 ! abnormal heart left atrium weight
is_a: MP:0031578 ! decreased heart left atrium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:20:51Z

[Term]
id: MP:0011915
name: increased heart left atrium weight
def: "more than average weight of the left atrium" [MPD:Molly]
is_a: MP:0008726 ! increased heart left atrium size
is_a: MP:0020206 ! abnormal heart left atrium weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:20:51Z

[Term]
id: MP:0011916
name: decreased heart right atrium weight
def: "less than average weight of the right atrium" [MPD:Molly]
synonym: "reduced heart right atrium weight" EXACT []
is_a: MP:0020207 ! abnormal heart right atrium weight
is_a: MP:0031579 ! decreased heart right atrium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:20:51Z

[Term]
id: MP:0011917
name: increased heart right atrium weight
def: "more than average weight of the right atrium" [MPD:Molly]
is_a: MP:0008727 ! increased heart right atrium size
is_a: MP:0020207 ! abnormal heart right atrium weight
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:20:51Z

[Term]
id: MP:0011918
name: abnormal PQ interval
def: "anomaly in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:44:21Z

[Term]
id: MP:0011919
name: abnormal R wave
def: "any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems" [MPD:Molly]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:44:21Z

[Term]
id: MP:0011920
name: abnormal S wave
def: "any anomaly in the S wave which represents the end of ventricular depolarization and corresponds to an isoelectric state rather than mechanical ventricular relaxation" [MPD:Molly]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:44:21Z

[Term]
id: MP:0011921
name: abnormal adrenal gland zona intermedia morphology
def: "any structural anomaly of the region between the zona glomerulosa and zona fasciculata that is relatively thin and contains mostly undifferentiated cells" [MPD:Molly]
synonym: "abnormal zona intermedia morphology" EXACT []
is_a: MP:0008288 ! abnormal adrenal cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:53:34Z

[Term]
id: MP:0011922
name: abnormal circulating osteocalcin level
def: "aberrant concentration in the blood of this noncollagenous protein hormone found in bone and dentin, which is secreted by osteoblasts" [MPD:Molly]
synonym: "abnormal circulating BGLAP level" EXACT []
synonym: "abnormal circulating bone gamma-carboxyglutamic acid-containing protein level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:55:35Z

[Term]
id: MP:0011923
name: abnormal bladder urine volume
def: "any anomaly in the amount of space occupied by urine in the bladder" [MPD:Molly]
is_a: MP:0010386 ! abnormal urinary bladder physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:56:46Z

[Term]
id: MP:0011924
name: abnormal liver zinc level
def: "anomaly in the amount of zinc present in the liver tissue" [MPD:Molly]
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0020893 ! abnormal zinc level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T13:57:41Z

[Term]
id: MP:0011925
name: abnormal heart echocardiography feature
def: "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:21:58Z

[Term]
id: MP:0011926
name: abnormal heart valve physiology
def: "any functional anomaly of the membranous folds of the heart that prevent reflux of fluid" [MESH:A07.541.510]
synonym: "abnormal cardiac valve physiology" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:24:43Z

[Term]
id: MP:0011927
name: abnormal cardiac valve flow
def: "any anomaly of the regulated one-way movement of blood through the heart valves" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011926 ! abnormal heart valve physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:26:09Z

[Term]
id: MP:0011928
name: abnormal mitral valve flow
def: "abnormality of valve function causing passive filling of the left ventricle or active filling of the left atrium" [MPD:Molly]
is_a: MP:0011927 ! abnormal cardiac valve flow
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:26:09Z

[Term]
id: MP:0011929
name: abnormal aortic valve flow
def: "abnormality impeding normal blood flow or allowing blood to backflow through this valve into the left ventricle" [MPD:Molly]
is_a: MP:0011927 ! abnormal cardiac valve flow
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:26:09Z

[Term]
id: MP:0011930
name: abnormal tricuspid valve flow
def: "abnormality of valve function causing passive filling of the right ventricle or active filling of the right atrium" [MPD:Molly]
is_a: MP:0011927 ! abnormal cardiac valve flow
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:26:09Z

[Term]
id: MP:0011931
name: abnormal pulmonary valve flow
def: "abnormality impeding normal blood flow or allowing blood to backflow through this valve into the right ventricle" [MPD:Molly]
is_a: MP:0011927 ! abnormal cardiac valve flow
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T14:26:09Z

[Term]
id: MP:0011932
name: abnormal endocrine pancreas development
def: "anomaly in the formation of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003934 ! abnormal pancreas development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T15:09:00Z

[Term]
id: MP:0011933
name: abnormal exocrine pancreas development
def: "anomaly in the formation of the acinar gland portion of the pancreas that secretes digestive enzymes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003934 ! abnormal pancreas development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T15:09:00Z

[Term]
id: MP:0011934
name: abnormal branching involved in pancreas development
def: "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
is_a: MP:0003934 ! abnormal pancreas development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T15:09:00Z

[Term]
id: MP:0011935
name: abnormal pancreatic bud formation
def: "any anomaly in the process in which the foregut region specified to become the pancreas forms a bud" [GO:0061130]
is_a: MP:0011934 ! abnormal branching involved in pancreas development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-07T15:11:37Z

[Term]
id: MP:0011936
name: abnormal PP interval
def: "any anomaly in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle; this value is often used in calculating heart rate and heart rate variability" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010508 ! abnormal heart electrocardiography waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-08T13:36:03Z

[Term]
id: MP:0011937
name: shortened PP interval
def: "decrease in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011936 ! abnormal PP interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-08T13:36:17Z

[Term]
id: MP:0011938
name: prolonged PP interval
def: "increase in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011936 ! abnormal PP interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-08T13:36:36Z

[Term]
id: MP:0011939
name: increased food intake
def: "increase in the total number of calories/food amount taken in over time when compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0005449 ! abnormal food intake
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T12:35:34Z

[Term]
id: MP:0011940
name: decreased food intake
def: "reduction in the total number of calories or food amount taken in over time when compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "anorexia" RELATED []
synonym: "hypophagia" EXACT []
synonym: "loss of appetite" RELATED []
synonym: "reduced food intake" EXACT []
is_a: MP:0005449 ! abnormal food intake
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T12:35:34Z

[Term]
id: MP:0011941
name: increased fluid intake
def: "increase in the total amount of fluid taken in over time when compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "increased liquid intake" RELATED []
is_a: MP:0011947 ! abnormal fluid intake
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T13:55:16Z

[Term]
id: MP:0011942
name: decreased fluid intake
def: "reduction in the total amount of fluid taken in over time when compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "decreased liquid intake" RELATED []
is_a: MP:0011947 ! abnormal fluid intake
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T13:55:16Z

[Term]
id: MP:0011943
name: abnormal circadian feeding behavior
def: "anomaly in the fluctuation pattern in feeding behavior (amount and instances) that occurs over an approximately 24 hour light/dark cycle" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal circadian feeding behaviour" EXACT []
is_a: MP:0001431 ! abnormal eating behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:14:50Z

[Term]
id: MP:0011944
name: abnormal eating frequency
def: "anomaly in the number of discrete instances of initiation of eating over time, regardless of amount eaten" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001431 ! abnormal eating behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:21:56Z

[Term]
id: MP:0011945
name: increased eating frequency
def: "increase in the number of discrete instances of initiation of eating over time, regardless of amount eaten" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011944 ! abnormal eating frequency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:23:38Z

[Term]
id: MP:0011946
name: decreased eating frequency
def: "reduction in the number of discrete instances of initiation of eating over time, regardless of amount eaten" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced eating frequency" EXACT []
is_a: MP:0011944 ! abnormal eating frequency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:23:38Z

[Term]
id: MP:0011947
name: abnormal fluid intake
def: "significant anomaly in the total amount of fluid taken in over time when compared to the normal state" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0001422 ! abnormal drinking behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:26:07Z

[Term]
id: MP:0011948
name: abnormal drinking frequency
def: "anomaly in the number of discrete instances of initiation of drinking over time, regardless of amount ingested" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001422 ! abnormal drinking behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:27:45Z

[Term]
id: MP:0011949
name: increased drinking frequency
def: "increase in the number of discrete instances of initiation of drinking over time, regardless of amount ingested" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011948 ! abnormal drinking frequency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:28:22Z

[Term]
id: MP:0011950
name: decreased drinking frequency
def: "reduction in the number of discrete instances of initiation of drinking over time, regardless of amount ingested" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced drinking frequency" EXACT []
is_a: MP:0011948 ! abnormal drinking frequency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:28:22Z

[Term]
id: MP:0011951
name: increased cardiac stroke volume
def: "increase in the volume of blood pushed into the aorta with each beat of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000304 ! abnormal cardiac stroke volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:46:38Z

[Term]
id: MP:0011952
name: decreased cardiac stroke volume
def: "reduction in the volume of blood pushed into the aorta with each beat of the heart" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000304 ! abnormal cardiac stroke volume
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T15:46:38Z

[Term]
id: MP:0011953
name: prolonged PQ interval
def: "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
is_a: MP:0011918 ! abnormal PQ interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T16:00:36Z

[Term]
id: MP:0011954
name: shortened PQ interval
def: "decrease in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
is_a: MP:0011918 ! abnormal PQ interval
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T16:00:36Z

[Term]
id: MP:0011955
name: phenotypic reversion by gene product interaction
def: "two or more mutant gene products, when existing together in one organism, result in a wild-type phenotype when each independent mutation shows a phenotype" [MGI:llw2]
is_a: MP:0003171 ! phenotypic reversion
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-11T22:13:27Z

[Term]
id: MP:0011956
name: abnormal compensatory feeding amount
def: "anomaly in the amount of food consumed after a period of fasting" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001431 ! abnormal eating behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-13T16:06:11Z

[Term]
id: MP:0011957
name: decreased compensatory feeding amount
def: "decreased amount of food consumed after a period of fasting" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced compensatory feeding amount" EXACT []
is_a: MP:0011940 ! decreased food intake
is_a: MP:0011956 ! abnormal compensatory feeding amount
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-13T16:06:11Z

[Term]
id: MP:0011958
name: increased compensatory feeding amount
def: "increased amount of food consumed after a period of fasting" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011939 ! increased food intake
is_a: MP:0011956 ! abnormal compensatory feeding amount
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-13T16:06:11Z

[Term]
id: MP:0011959
name: abnormal eye posterior chamber depth
def: "anomaly in the distance between the iris and the lens at the center plane (maximum distance) of the posterior chamber, compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal PCD" EXACT []
is_a: MP:0005299 ! abnormal eye posterior chamber morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T13:59:20Z

[Term]
id: MP:0011960
name: abnormal eye anterior chamber depth
def: "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the eye anterior chamber compared to controls" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal ACD" EXACT []
is_a: MP:0005205 ! abnormal eye anterior chamber morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T14:25:09Z

[Term]
id: MP:0011961
name: abnormal cornea thickness
def: "increased or decreased width of the cornea in the center plane" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal corneal thickness" EXACT []
synonym: "abnormal tunica cornea thickness" EXACT []
is_a: MP:0031498 ! abnormal cornea size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T14:46:10Z

[Term]
id: MP:0011962
name: increased cornea thickness
def: "increased width of the cornea in the center plane" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "increased corneal thickness" EXACT []
synonym: "increased tunica cornea thickness" EXACT []
is_a: MP:0011961 ! abnormal cornea thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T14:53:47Z

[Term]
id: MP:0011963
name: abnormal total retina thickness
def: "increased or decreased width of the retina through the center plane" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal total retinal thickness" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T15:03:08Z

[Term]
id: MP:0011964
name: increased total retina thickness
def: "increased width of the retina through the center plane" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "increased total retinal thickness" EXACT []
is_a: MP:0011963 ! abnormal total retina thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T15:04:09Z

[Term]
id: MP:0011965
name: decreased total retina thickness
def: "decreased width of the retina through the center plane" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "decreased total retinal thickness" EXACT []
synonym: "reduced total retina thickness" EXACT []
synonym: "reduced total retinal thickness" EXACT []
synonym: "retina thinning" EXACT []
synonym: "retinal thinning" EXACT []
synonym: "thin retina" EXACT []
is_a: MP:0011963 ! abnormal total retina thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-03-15T15:04:09Z

[Term]
id: MP:0011966
name: abnormal auditory brainstem response waveform shape
def: "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0004738 ! abnormal auditory brainstem response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-04T12:51:28Z

[Term]
id: MP:0011967
name: increased or absent threshold for auditory brainstem response
def: "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "absent ABRs" NARROW []
synonym: "absent BAEP(s)" NARROW []
synonym: "absent brainstem auditory brainstem response(s)" NARROW []
synonym: "absent brainstem auditory evoked potential" NARROW []
synonym: "absent brainstem evoked responses" NARROW []
is_a: MP:0004738 ! abnormal auditory brainstem response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-04T12:52:39Z

[Term]
id: MP:0011968
name: decreased threshold for auditory brainstem response
def: "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0004738 ! abnormal auditory brainstem response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-04T12:52:59Z

[Term]
id: MP:0011969
name: abnormal circulating triglyceride level
def: "abnormal concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000187 ! abnormal triglyceride level
is_a: MP:0003949 ! abnormal circulating lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-04T16:10:51Z

[Term]
id: MP:0011970
name: abnormal circulating lactate dehydrogenase level
def: "abnormal blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [https://orcid.org/0000-0003-3691-0324, MeSH:D08.811.682.047.551.400]
subset: IMPC
synonym: "abnormal circulating LDH level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
is_a: MP:0002943 ! abnormal lactate dehydrogenase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-05T12:37:05Z

[Term]
id: MP:0011971
name: increased circulating lactate dehydrogenase level
def: "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [https://orcid.org/0000-0003-3691-0324, MeSH:D08.811.682.047.551.400]
subset: IMPC
synonym: "increased circulating LDH level" EXACT []
is_a: MP:0002944 ! increased lactate dehydrogenase level
is_a: MP:0011970 ! abnormal circulating lactate dehydrogenase level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-05T12:37:05Z

[Term]
id: MP:0011972
name: decreased circulating lactate dehydrogenase level
def: "reduced blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [https://orcid.org/0000-0003-3691-0324, MeSH:D08.811.682.047.551.400]
subset: IMPC
synonym: "decreased circulating LDH level" EXACT []
is_a: MP:0005571 ! decreased lactate dehydrogenase level
is_a: MP:0011970 ! abnormal circulating lactate dehydrogenase level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-05T12:37:05Z

[Term]
id: MP:0011973
name: abnormal circulating glycerol level
def: "abnormal blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0003439 ! abnormal glycerol level
is_a: MP:0003949 ! abnormal circulating lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-05T13:35:12Z

[Term]
id: MP:0011974
name: intestinal stenosis
def: "abnormal narrowing or constriction of the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus" [MGI:llw2]
synonym: "intestine stenosis" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-08T15:15:23Z

[Term]
id: MP:0011975
name: neuronal cytoplasmic inclusions
def: "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [https://orcid.org/0000-0003-0431-8641]
is_a: MP:0002882 ! abnormal neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-08T15:20:07Z

[Term]
id: MP:0011976
name: sweet preference
def: "subjects demonstrate predilection for sweet tasting substances over other offered substance" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001432 ! abnormal food preference
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-04-16T12:20:09Z

[Term]
id: MP:0011977
name: abnormal sodium ion homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of sodium ions within the body or between a cell and its external environment" [MPD:Molly]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-03T15:48:46Z

[Term]
id: MP:0011978
name: abnormal potassium ion homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of potassium ions within the body or between a cell and its external environment" [MPD:Molly]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-03T15:48:46Z

[Term]
id: MP:0011979
name: abnormal magnesium ion homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of magnesium ions within the body or between a cell and its external environment" [MPD:Molly]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-03T15:48:46Z

[Term]
id: MP:0011980
name: absent Langerhans cell precursors
def: "absence of the yolk sac-derived primitive myeloid progenitors that populate the skin before the onset of fetal liver hematopoiesis" [PMID:22565823]
is_a: MP:0008115 ! abnormal dendritic cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:12:34Z

[Term]
id: MP:0011981
name: abnormal microglial cell differentiation
def: "atypical production of or inability to produce the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system" [PMID:22729249]
is_a: MP:0000136 ! abnormal microglial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:15:28Z

[Term]
id: MP:0011982
name: decreased microglial cell number
def: "reduced number of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system" [PMID:22046273]
is_a: MP:0000136 ! abnormal microglial cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:16:47Z

[Term]
id: MP:0011983
name: abnormal Ito cell differentiation
def: "atypical production of or inability to produce the fat-storing cells that line the hepatic sinusoids" [PMID:9407545]
synonym: "abnormal hepatic stellate cell differentiation" EXACT []
is_a: MP:0008990 ! abnormal Ito cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:18:26Z

[Term]
id: MP:0011984
name: decreased enteroendocrine cell number
def: "reduction in the number of the various hormone- or neurotransmitter-secreting epithelial cells present throughout the mucosa of the digestive tract" [PMID:23451116]
is_a: MP:0004141 ! abnormal enteroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:20:26Z

[Term]
id: MP:0011985
name: abnormal macrophage proliferation
def: "anomaly in the ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0002451 ! abnormal macrophage physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:38:29Z

[Term]
id: MP:0011986
name: decreased macrophage proliferation
def: "reduced ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235]
synonym: "reduced macrophage proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0011985 ! abnormal macrophage proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T15:38:54Z

[Term]
id: MP:0011987
name: abnormal GABAergic neuron physiology
def: "any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]
is_a: MP:0004811 ! abnormal neuron physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-06T16:00:42Z

[Term]
id: MP:0011988
name: increased mating frequency
def: "increased number of attempts of sexual behavioral contact between an initiating organism and a receptive partner" [MESH:F01.145.113.252.748.200]
synonym: "increased coitus frequency" EXACT []
synonym: "increased copulation frequency" BROAD []
is_a: MP:0001377 ! abnormal mating frequency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T12:41:02Z

[Term]
id: MP:0011989
name: abnormal porphyrin level
def: "aberrant concentration of porphyrins or protoporphyrins" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T12:45:27Z

[Term]
id: MP:0011990
name: decreased porphyrin level
def: "reduced concentration of porphyrins or protoporphyrins" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced porphyrin level" EXACT []
is_a: MP:0011989 ! abnormal porphyrin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T12:45:46Z

[Term]
id: MP:0011991
name: aortic cartilaginous metaplasia
def: "transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta" [https://orcid.org/0000-0003-3691-0324, PMID:7489252]
is_a: MP:0000272 ! abnormal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T14:05:35Z

[Term]
id: MP:0011992
name: increased erythrocyte catalase activity
def: "greater capacity to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O, in erythorcytes" [GO:0004096, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011593 ! increased catalase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T15:48:42Z

[Term]
id: MP:0011993
name: increased foot pad temperature
def: "increased degree of heat natural to the foot pad-environment interface of a living being" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005533 ! increased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T15:58:24Z

[Term]
id: MP:0011994
name: increased nerve conduction velocity
def: "increase in the rate at which an electrical impulse travels through a nerve" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased nerve conduction" RELATED []
is_a: MP:0005403 ! abnormal nerve conduction
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T16:03:20Z

[Term]
id: MP:0011995
name: decreased leukemia incidence
def: "less than the expected number of neoplasms derived from blood or bone marrow in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased leucaemia incidence" EXACT []
synonym: "decreased leukaemia incidence" EXACT []
is_a: MP:0010283 ! decreased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T16:18:55Z

[Term]
id: MP:0011996
name: abnormal retina inner nuclear layer thickness
def: "anomaly in the thickness of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal retinal INL thickness" EXACT []
synonym: "abnormal retinal inner nuclear layer thickness" EXACT []
is_a: MP:0003733 ! abnormal retina inner nuclear layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T16:24:04Z

[Term]
id: MP:0011997
name: abnormal retina outer nuclear layer thickness
def: "anomaly in the thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal retina ONL thickness" EXACT []
synonym: "abnormal retinal ONL thickness" EXACT []
synonym: "abnormal retinal outer nuclear layer thickness" EXACT []
is_a: MP:0003731 ! abnormal retina outer nuclear layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T16:25:32Z

[Term]
id: MP:0011998
name: decreased embryonic cilium length
def: "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased embryonic cilia length" EXACT []
synonym: "short embryonic cilia" EXACT []
synonym: "stubby embryonic cilia" EXACT []
is_a: MP:0004131 ! abnormal motile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-14T16:44:48Z

[Term]
id: MP:0011999
name: abnormal tail length
def: "any anomaly in the length of tail relative to average of a given reference population" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0002111 ! abnormal tail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-20T14:42:10Z

[Term]
id: MP:0012000
name: abnormal limb position
def: "anomaly in the location or orientation of the limbs on the body relative to other body parts or axes" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0002109 ! abnormal limb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-20T14:45:09Z

[Term]
id: MP:0012001
name: abnormal touch escape response
def: "anomaly in the ability of an animal to respond to the approach of a human hand by fleeing from it" [PMID:10563494]
subset: IMPC
is_a: MP:0002067 ! abnormal sensory capabilities/reflexes/nociception
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-20T15:38:46Z

[Term]
id: MP:0012002
name: impaired touch escape response
def: "impaired ability of an animal to respond to the approach of a human hand by fleeing from it, including fleeing only after a touch or stroke, or not responding to touch by fleeing" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0012001 ! abnormal touch escape response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-05-20T15:42:41Z

[Term]
id: MP:0012003
name: abnormal septum of telencephalon morphology
def: "any structural anomaly of the gray matter structures of the telencephalon and limbic system in the brain; included is the cortical septal area, subcortical septal nuclei, and the septum pellucidum; however, many authorities consider the septal region to be made up of the septal area and the septal nuclei, but excluding the septum pellucidum" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000787 ! abnormal telencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-06-10T16:02:44Z

[Term]
id: MP:0012004
name: abnormal septum pellucidum morphology
def: "any structural anomaly of the thin, triangular, vertical membrane separating the anterior horns of the left and right lateral ventricles of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala" [https://orcid.org/0000-0003-3691-0324, MPD:Molly]
synonym: "abnormal lateral septum morphology" EXACT []
synonym: "abnormal septum lucidum morphology" EXACT []
is_a: MP:0012003 ! abnormal septum of telencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-06-10T16:14:10Z

[Term]
id: MP:0012005
name: abnormal septum pellucidum size
def: "anomaly in the size of the thin, triangular, vertical membrane separating the anterior horns of the left and righ of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala" [https://orcid.org/0000-0003-3691-0324, MPD:Molly]
synonym: "abnormal lateral septum size" EXACT []
synonym: "abnormal septum lucidum size" EXACT []
is_a: MP:0012004 ! abnormal septum pellucidum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-06-10T16:14:10Z

[Term]
id: MP:0012006
name: abnormal hippocampus physiology
def: "any functional anomaly related to processes in the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [MPD:Molly]
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-07-05T09:34:16Z

[Term]
id: MP:0012007
name: abnormal chloride level
def: "any change in the amount of chloride, the major extracellular anion in mammals; it plays roles in tissue fluid homeostasis and also helps maintain proper blood volume, blood pressure, and body fluid pH" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-07-05T13:46:56Z

[Term]
id: MP:0012008
name: delayed parturition
def: "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002907 ! abnormal parturition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T10:28:07Z

[Term]
id: MP:0012009
name: early parturition
def: "the process of labor and delivery in female animals occurs earlier in gestation than expected" [https://orcid.org/0000-0003-3691-0324]
synonym: "preterm labor" RELATED []
synonym: "preterm labour" RELATED []
is_a: MP:0002907 ! abnormal parturition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T10:28:07Z

[Term]
id: MP:0012010
name: parturition failure
def: "the process of labor and delivery in female animals does not initiate or complete" [https://orcid.org/0000-0003-3691-0324]
synonym: "failure of parturition" EXACT []
is_a: MP:0002907 ! abnormal parturition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T10:28:07Z

[Term]
id: MP:0012011
name: febrile seizures
def: "a convulsion associated with a significant rise in body temperature (fever)" [https://orcid.org/0000-0003-3691-0324]
synonym: "febrile convulsion" EXACT []
is_a: MP:0002064 ! seizures
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T15:08:40Z

[Term]
id: MP:0012012
name: abnormal innate olfactory avoidance response
def: "any anomaly in the naive behavioral response of an individual to an aversive olfactory stimulus, in which the tendency to act defensively is stronger than the tendency to attack" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012013 ! abnormal innate avoidance response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T16:15:28Z

[Term]
id: MP:0012013
name: abnormal innate avoidance response
def: "any anomaly in the naive behavioral response of an individual to an aversive stimulus, in which the tendency to act defensively is stronger than the tendency to attack" [https://orcid.org/0000-0003-4606-0597, NBO:0000635]
xref: NBO:0000635
is_a: MP:0002572 ! abnormal emotion/affect behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-07T16:17:37Z

[Term]
id: MP:0012014
name: abnormal olfactory neuron innervation pattern
def: "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T09:21:55Z

[Term]
id: MP:0012015
name: abnormal eumelanosome eumelanin content
def: "anomaly in the amount or distribution of black (or brown) pigment in the eumelanosomes of melanocytes" [MGI:llw2]
is_a: MP:0013314 ! abnormal eumelanosome morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T09:52:22Z

[Term]
id: MP:0012016
name: abnormal hair follicle eumelanosome eumelanin content
def: "anomaly in the amount or distribution of black (or brown) pigment in the eumelanosomes of the hair follicle melanocytes" [MGI:llw2]
is_a: MP:0004381 ! abnormal hair follicle melanocyte morphology
is_a: MP:0012015 ! abnormal eumelanosome eumelanin content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T09:52:22Z

[Term]
id: MP:0012017
name: grizzled coat color
def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased compared to wild-type agouti producing hair that is partly gray or streaked with gray" [MGI:llw2]
synonym: "chinchilla effect" EXACT []
synonym: "grey coat color" RELATED []
synonym: "grey coat colour" RELATED []
synonym: "grizzled coat colour" EXACT []
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T09:56:27Z

[Term]
id: MP:0012018
name: abnormal oviduct physiology
def: "any functional anomaly of the tube through which the ova pass from the ovary to the uterus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fallopian tube physiology" EXACT []
synonym: "abnormal salpinges physiology" EXACT []
synonym: "abnormal salpinx physiology" EXACT []
synonym: "abnormal salpinx uterina physiology" EXACT []
synonym: "abnormal tuba fallopiana physiology" EXACT []
synonym: "abnormal tuba fallopii physiology" EXACT []
synonym: "abnormal tuba uterina physiology" EXACT []
synonym: "abnormal uterine tube physiology" EXACT []
is_a: MP:0003699 ! abnormal female reproductive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T10:17:59Z

[Term]
id: MP:0012019
name: abnormal oviduct epithelium motile cilium physiology
def: "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012018 ! abnormal oviduct physiology
is_a: MP:0013209 ! abnormal motile cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T10:19:22Z

[Term]
id: MP:0012020
name: abnormal olfactory epithelium physiology
def: "any functional anomaly in the epithelial cells that line the interior of the nose" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal nasal epithelium physiology" EXACT []
is_a: MP:0001983 ! abnormal olfactory system physiology
is_a: MP:0014200 ! abnormal respiratory epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T11:32:39Z

[Term]
id: MP:0012021
name: abnormal melanocyte number
def: "deviation from the average number of the cells that produce pigment" [MGI:llw2]
is_a: MP:0002877 ! abnormal melanocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:14:54Z

[Term]
id: MP:0012022
name: increased melanocyte number
def: "greater number of the cells that produce pigment" [MGI:llw2]
is_a: MP:0012021 ! abnormal melanocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:21:42Z

[Term]
id: MP:0012023
name: decreased melanocyte number
def: "reduced number of the cells that produce pigment" [MGI:llw2]
is_a: MP:0012021 ! abnormal melanocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:21:42Z

[Term]
id: MP:0012024
name: abnormal nephron morphogenesis
def: "any anomaly in the process in which the nephron is generated and organized; the nephron is the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003881 ! abnormal nephron morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:33:19Z

[Term]
id: MP:0012025
name: abnormal comma shaped body morphology
def: "any structural anomaly of precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron" [GO:0072049]
synonym: "abnormal CSB morphology" EXACT []
is_a: MP:0012024 ! abnormal nephron morphogenesis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:33:51Z

[Term]
id: MP:0012026
name: abnormal S-shaped body morphology
def: "any structural anomaly of the successor of the comma-shaped body that contributes to the morphogenesis of the nephron" [GO:0072050]
synonym: "abnormal SSB morphology" EXACT []
synonym: "abnormal stage II nephron morphology" EXACT []
is_a: MP:0012024 ! abnormal nephron morphogenesis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:34:05Z

[Term]
id: MP:0012027
name: abnormal embryonic cilium location or orientation
def: "embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal embryonic cilium polarization" RELATED []
is_a: MP:0004131 ! abnormal motile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T12:47:46Z

[Term]
id: MP:0012028
name: abnormal visceral endoderm physiology
def: "any functional anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [https://orcid.org/0000-0003-3691-0324, PMID:21123814]
is_a: MP:0005380 ! embryo phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T13:32:10Z

[Term]
id: MP:0012029
name: abnormal electroretinogram waveform feature
def: "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ERG waveform feature" EXACT []
is_a: MP:0005253 ! abnormal eye physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:02:21Z

[Term]
id: MP:0012030
name: abnormal a-wave amplitude
def: "anomaly in the size (height or maximum displacement) of the a-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012034 ! abnormal a-wave shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:07:48Z

[Term]
id: MP:0012031
name: abnormal b-wave amplitude
def: "anomaly in the size (height or maximum displacement) of the b-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012035 ! abnormal b-wave shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:08:11Z

[Term]
id: MP:0012032
name: abnormal ERG latency
def: "anomaly in the time from onset of stimulus to beginning of a waveform feature" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:11:57Z

[Term]
id: MP:0012033
name: abnormal ERG implicit time
def: "anomaly in the time from the onset of light stimulus to the peak of a waveform feature" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:12:39Z

[Term]
id: MP:0012034
name: abnormal a-wave shape
def: "any anomaly in the graphical representation of the a-wave in the electroretinogram; the a-wave represents the general physiological health of the photoreceptors in the outer retina" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:18:49Z

[Term]
id: MP:0012035
name: abnormal b-wave shape
def: "any anomaly in the graphical representation of the b-wave in the electroretinogram; the b-wave represents the health of the inner layers of the retina, including the ON bipolar cells and the Muller cells" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:19:19Z

[Term]
id: MP:0012036
name: abnormal a-wave latency
def: "anomaly in the time from onset of stimulus to beginning of the a-wave" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012032 ! abnormal ERG latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:21:37Z

[Term]
id: MP:0012037
name: abnormal b-wave latency
def: "anomaly in the time from onset of stimulus to beginning of the b-wave" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012032 ! abnormal ERG latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:21:37Z

[Term]
id: MP:0012038
name: abnormal a-wave implicit time
def: "anomaly in the time from the onset of light stimulus to the peak of the a-wave" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012033 ! abnormal ERG implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:22:02Z

[Term]
id: MP:0012039
name: abnormal b-wave implicit time
def: "anomaly in the time from the onset of light stimulus to the peak of the b-wave" [http://webvision.med.utah.edu, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012033 ! abnormal ERG implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:22:02Z

[Term]
id: MP:0012040
name: abnormal c-wave shape
def: "any anomaly in the graphical representation of the c-wave in the electroretinogram; the ERG c-wave can be used to assess the functional integrity of the photoreceptors, the pigment epithelial cells and the interactions between them." [http:webvision.med.utah.edu/book/electrophysiology/the-electroretinogram-erg/, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T14:51:43Z

[Term]
id: MP:0012041
name: increased susceptibility to pulmonary hyaline membrane formation
def: "increased likelihood of the presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased resistance to pulmonary hyaline membrane formation" EXACT []
synonym: "susceptible to pulmonary hyaline membrane formation" EXACT []
is_a: MP:0011018 ! pulmonary hyaline membrane formation
is_a: MP:0031106 ! abnormal susceptibility to pulmonary hyaline membrane formation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T15:13:23Z

[Term]
id: MP:0012042
name: low alcohol preference
def: "decreased predilection to ingest alcohol over other substances" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001425 ! abnormal alcohol consumption
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T15:18:26Z

[Term]
id: MP:0012043
name: increased myoepithelioma incidence
def: "greater than the expected occurrence of a benign tumor of myoepithelial cells, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
synonym: "increased benign myoepithelial tumor incidence" EXACT []
synonym: "increased benign myoepithelial tumour incidence" EXACT []
synonym: "increased myoepithelial adenoma incidence" EXACT []
is_a: MP:0010273 ! increased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T15:24:38Z

[Term]
id: MP:0012044
name: abnormal phospholipase A2 level
def: "any anomaly in the amount of any of the enzymes that hydrolize the acyl group attached to the two-position of phosphoglycerides" [MESH:D08.811.277.352.100.680.750.937]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T15:50:44Z

[Term]
id: MP:0012045
name: increased susceptibility to hypertension
def: "more likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000231 ! hypertension
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T16:02:34Z

[Term]
id: MP:0012046
name: decreased susceptibility to hypertension
def: "less likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000231 ! hypertension
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T16:02:34Z

[Term]
id: MP:0012047
name: abnormal cholinesterase level
def: "anomaly in the amount of any of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-08T16:07:51Z

[Term]
id: MP:0012048
name: abnormal response to retina ischemic injury
def: "altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal response to retina ischaemic injury" EXACT []
synonym: "abnormal response to retinal ischaemic injury" EXACT []
synonym: "abnormal response to retinal ischemic injury" EXACT []
synonym: "altered response to retinal ischaemic injury" EXACT []
synonym: "altered response to retinal ischemic injury" EXACT []
is_a: MP:0005164 ! abnormal response to injury
is_a: MP:0005253 ! abnormal eye physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:33:35Z

[Term]
id: MP:0012049
name: increased susceptilbility to retina ischemic injury
def: "more severe response, such as increased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of the retina compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased susceptilbility to retinal ischaemia" RELATED []
synonym: "increased susceptilbility to retinal ischaemic injury" EXACT []
synonym: "increased susceptilbility to retinal ischemia" RELATED []
synonym: "increased susceptilbility to retinal ischemic injury" EXACT []
is_a: MP:0005165 ! increased susceptibility to injury
is_a: MP:0012048 ! abnormal response to retina ischemic injury
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:35:35Z

[Term]
id: MP:0012050
name: decreased susceptilbility to retina ischemic injury
def: "less severe response, such as decreased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of the retina compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptilbility to retinal ischaemia" RELATED []
synonym: "decreased susceptilbility to retinal ischaemic injury" EXACT []
synonym: "decreased susceptilbility to retinal ischemia" RELATED []
synonym: "decreased susceptilbility to retinal ischemic injury" EXACT []
is_a: MP:0005166 ! decreased susceptibility to injury
is_a: MP:0012048 ! abnormal response to retina ischemic injury
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:35:35Z

[Term]
id: MP:0012051
name: spasticity
def: "a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch" [HP:0001257, https://orcid.org/0000-0003-3691-0324]
xref: HP:0001257
xref: UMLS:C0026838
is_a: MP:0003491 ! abnormal voluntary movement
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:50:57Z

[Term]
id: MP:0012052
name: hypertonicity
def: "abnormally increased muscle tone or strength that impairs proper movement" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012051 ! spasticity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:53:14Z

[Term]
id: MP:0012053
name: limb hypertonicity
def: "limbs exhibit abnormally increased muscle tone; can be due to muscle genetic defects or some CNS disorders and may be evident in arm or leg deformities" [https://orcid.org/0000-0003-3691-0324]
synonym: "limb hypertonia" EXACT []
is_a: MP:0012052 ! hypertonicity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T08:53:46Z

[Term]
id: MP:0012054
name: abnormal phrenic nerve innervation pattern
def: "any changes in the placement, morphology or number of phrenic nerve fibers providing motor supply to the diaphragm as well as sensory fibers to the central tendon, or in the thorax, phrenic nerve sensory fibers to the mediastinal pleura and pericardium" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001078 ! abnormal phrenic nerve morphology
is_a: MP:0002184 ! abnormal innervation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:08:34Z

[Term]
id: MP:0012055
name: abnormal phrenic nerve innervation pattern to diaphragm
def: "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000940 ! abnormal motor neuron innervation pattern
is_a: MP:0001052 ! abnormal innervation pattern to muscle
is_a: MP:0012054 ! abnormal phrenic nerve innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:15:57Z

[Term]
id: MP:0012056
name: abnormal polar trophectoderm morphology
def: "any structural anomaly of the trophectoderm portion that surrounds the inner cell mass (ICM); unlike mural trophectoderm cells which stop proliferating and become large polyploid cells (the primary trophoblastic giant cells) by endoreduplication, polar trophectoderm cells remain diploid, continue to proliferate and give rise to both the ectoplacental cone and the extraembryonic ectoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005028 ! abnormal trophectoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:21:13Z

[Term]
id: MP:0012057
name: abnormal mural trophectoderm morphology
def: "any structural anomaly of the trophectoderm portion distal to the ICM that overlays the blastocyst cavity and gives rise to polyploid trophoblast giant cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005028 ! abnormal trophectoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:21:13Z

[Term]
id: MP:0012058
name: abnormal morula morphology
def: "any structural anomaly of the globular solid mass of blastomeres formed by cleavage of a zygote that typically precedes the blastula, typically after the zygote has divided into 32 cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014137 ! abnormal preimplantation embryo morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:32:07Z

[Term]
id: MP:0012059
name: thick diaphragm muscle
def: "increased thickness of the diaphragm muscle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002279 ! abnormal diaphragm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-09T09:56:49Z

[Term]
id: MP:0012060
name: diaphragm muscle hyperplasia
def: "increase in the number of normal cells in normal arrangement in the diaphragm muscle, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic diaphragm muscle" EXACT []
is_a: MP:0002279 ! abnormal diaphragm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T08:44:06Z

[Term]
id: MP:0012061
name: abnormal diaphragm central tendon morphology
def: "any structural anomaly of the three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal central tendon of diaphragm morphology" EXACT []
is_a: MP:0002279 ! abnormal diaphragm morphology
is_a: MP:0005503 ! abnormal tendon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T08:47:07Z

[Term]
id: MP:0012062
name: small tail bud
def: "decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased tail bud size" EXACT []
synonym: "reduced tail bud size" EXACT []
is_a: MP:0002861 ! abnormal tail bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T09:06:20Z

[Term]
id: MP:0012063
name: absent tail bud
def: "missing the primordial region of the embryo that arises to form the tail of the adult" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002861 ! abnormal tail bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T09:06:20Z

[Term]
id: MP:0012064
name: abnormal astrocyte number
def: "anomaly in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal astrocytic glia number" EXACT []
synonym: "abnormal astroglia number" EXACT []
synonym: "abnormal astroglial cell number" EXACT []
is_a: MP:0002182 ! abnormal astrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T09:10:22Z

[Term]
id: MP:0012065
name: increased astrocyte number
def: "increase in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, https://orcid.org/0000-0003-3691-0324]
synonym: "increased astrocytic glia number" EXACT []
synonym: "increased astroglial cell number" EXACT []
is_a: MP:0012064 ! abnormal astrocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T09:10:22Z

[Term]
id: MP:0012066
name: decreased astrocyte number
def: "reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased astrocytic glia number" EXACT []
synonym: "decreased astroglia number" EXACT []
synonym: "decreased astroglial cell number" EXACT []
synonym: "reduced astrocyte number" EXACT []
synonym: "reduced astrocytic glia number" EXACT []
is_a: MP:0012064 ! abnormal astrocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T09:10:22Z

[Term]
id: MP:0012067
name: abnormal olfactory gland morphology
def: "any structural anomaly of the Bowman's glands (aka glands of Bowman, olfactory glands), situated in the olfactory mucosa, beneath the olfactory epithelium, in the lamina propria, a connective tissue also containing fibroblasts, blood vessels, and bundles of fine axons from the olfactory neurons; Bowman's glands consists of an acinus in the lamina propria and a secretory duct going out through the olfactory epithelium" [UBERON:0002232]
synonym: "abnormal Bowman's gland morphology" EXACT []
synonym: "abnormal olfactory gland of Bowman morphology" EXACT []
is_a: MP:0005499 ! abnormal olfactory system morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T10:39:49Z

[Term]
id: MP:0012068
name: abnormal globose cell of olfactory epithelium morphology
def: "any structural anomaly of the rounded or elliptical epithelial cells, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles, that form a distinct basal zone spaced slightly from the basal surface of the olfactory epithelium" [CL:0002171]
synonym: "abnormal globose basal cell morphology" EXACT []
synonym: "abnormal globose cell morphology" BROAD []
is_a: MP:0008789 ! abnormal olfactory epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T10:47:39Z

[Term]
id: MP:0012069
name: abnormal horizontal basal cell of olfactory epithelium morphology
def: "any structural anomaly of the flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells, that lie in contact with the basal lamina of olfactory epithelium" [CL:0002184]
synonym: "abnormal basal proper cell of olfactory epithelium morphology" EXACT []
synonym: "abnormal horizontal basal cell morphology" EXACT []
synonym: "abnormal horizontal basal cells" BROAD []
is_a: MP:0008789 ! abnormal olfactory epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T10:56:08Z

[Term]
id: MP:0012070
name: abnormal susceptibility to osteoporosis
def: "a change in the likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility" [https://orcid.org/0000-0003-3691-0324]
synonym: "altered susceptibility to osteoporosis" EXACT []
is_a: MP:0003795 ! abnormal bone structure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T11:23:30Z

[Term]
id: MP:0012071
name: increased susceptibility to osteoporosis
def: "greater likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased resistance to osteoporosis" EXACT []
synonym: "increased susceptibility to bone loss" RELATED []
is_a: MP:0012070 ! abnormal susceptibility to osteoporosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T11:24:33Z

[Term]
id: MP:0012072
name: decreased susceptibility to osteoporosis
def: "reduced likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased susceptibility to bone loss" RELATED []
synonym: "increased resistance to osteoporosis" EXACT []
synonym: "reduced susceptibility to osteoporosis" EXACT []
is_a: MP:0012070 ! abnormal susceptibility to osteoporosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T11:24:33Z

[Term]
id: MP:0012073
name: premature mammary gland growth during pregnancy
def: "faster progression of the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
is_a: MP:0006269 ! abnormal mammary gland growth during pregnancy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T18:24:43Z

[Term]
id: MP:0012074
name: failure of mammary gland growth during pregnancy
def: "arrest, or failure to initiate the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
synonym: "arrested mammary gland growth during pregnancy" NARROW []
is_a: MP:0012075 ! impaired mammary gland growth during pregnancy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T18:24:43Z

[Term]
id: MP:0012075
name: impaired mammary gland growth during pregnancy
def: "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
is_a: MP:0006269 ! abnormal mammary gland growth during pregnancy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T18:24:43Z

[Term]
id: MP:0012076
name: abnormal agouti pigmentation
def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from yellow to almost black" [MGI:llw2]
comment: This term is rodent specific.
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-10T20:58:27Z

[Term]
id: MP:0012077
name: webbed neck
def: "the skin on the neck appears as loose folds that develop a web-like appearance from the ears to the shoulder during growth and maturation" [https://orcid.org/0000-0003-0431-8641]
comment: Webbed neck describes a condition that occurs in patients with Turner syndrome, Noonan syndrome, and less frequently Klippel-Feil syndrome.
synonym: "pterygium colli deformity" EXACT []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0030528 ! abnormal neck skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-11T07:43:28Z

[Term]
id: MP:0012078
name: abnormal tail ring morphology
def: "any structural anomaly of the segmentally patterned skin ridges appearing on the tail of rodents" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal tail band morphology" EXACT []
synonym: "abnormal tail ridge morphology" EXACT []
is_a: MP:0001191 ! abnormal skin condition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-11T08:23:29Z

[Term]
id: MP:0012079
name: abnormal spinal reflex
def: "any anomaly in the reflexive action mediated by cells of the spinal cord, or the involuntary movement reaction caused by the application of a stimulus to an organism; these include signals originating from heat from burning, sharp sensations, and other painful feelings" [GO:0050883, https://orcid.org/0000-0003-3691-0324]
xref: GO:0050883
is_a: MP:0001961 ! abnormal reflex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-11T08:37:41Z

[Term]
id: MP:0012080
name: chylous ascites
def: "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005324 ! ascites
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-08-11T09:07:40Z

[Term]
id: MP:0012081
name: absent heart tube
def: "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cardiac tube" EXACT []
synonym: "cardiac tube agenesis" EXACT []
synonym: "heart tube agenesis" EXACT []
synonym: "missing heart tube" EXACT []
is_a: MP:0000270 ! abnormal heart tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T09:33:35Z

[Term]
id: MP:0012082
name: delayed heart development
def: "late onset of the induction and/or differentiation of the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed cardiac development" EXACT []
synonym: "delayed cardiogenesis" EXACT []
is_a: MP:0000267 ! abnormal heart development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T09:40:56Z

[Term]
id: MP:0012083
name: absent foregut
def: "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [https://orcid.org/0000-0002-6490-7723]
synonym: "foregut agenesis" EXACT []
synonym: "missing foregut" EXACT []
is_a: MP:0000474 ! abnormal foregut morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T09:54:53Z

[Term]
id: MP:0012084
name: truncated foregut
def: "shortened foregut that terminates abruptly as if having an end or point cut off" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000474 ! abnormal foregut morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T09:57:13Z

[Term]
id: MP:0012085
name: midface hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the midface, typically resulting in decreased size and leading to a concave-looking face" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic midface" EXACT []
synonym: "mid-face hypoplasia" EXACT []
synonym: "midface retrusion" EXACT [https://www.ncbi.nlm.nih.gov/medgen/339938]
synonym: "midfacial hypoplasia" EXACT []
is_a: MP:0000443 ! abnormal snout morphology
is_a: MP:0030065 ! face hypoplasia
is_a: MP:0030095 ! abnormal midface morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:04:32Z

[Term]
id: MP:0012086
name: absent hindgut
def: "absence of the caudal portion of the primitive digestive tube of the embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "hindgut agenesis" EXACT []
synonym: "missing hindgut" EXACT []
is_a: MP:0008786 ! abnormal hindgut morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:20:48Z

[Term]
id: MP:0012087
name: absent midbrain
def: "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent mesencephalon" EXACT []
synonym: "mesencephalon agenesis" EXACT []
synonym: "midbrain agenesis" EXACT []
synonym: "missing mesencephalon" EXACT []
synonym: "missing midbrain" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:32:14Z

[Term]
id: MP:0012088
name: abnormal midbrain size
def: "deviation from the average range of midbrain size compared to normal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal mesencephalon size" EXACT []
is_a: MP:0000771 ! abnormal brain size
is_a: MP:0000897 ! abnormal midbrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:32:14Z

[Term]
id: MP:0012089
name: decreased midbrain size
def: "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased mesencephalon size" EXACT []
synonym: "reduced mesencephalon size" EXACT []
synonym: "reduced midbrain size" EXACT []
synonym: "small mesencephalon" EXACT []
synonym: "small midbrain" EXACT []
synonym: "truncated mesencephalon" EXACT []
synonym: "truncated midbrain" EXACT []
is_a: MP:0000774 ! decreased brain size
is_a: MP:0012088 ! abnormal midbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:32:14Z

[Term]
id: MP:0012090
name: midbrain hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the midbrain, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "hypoplastic mesencephalon" EXACT []
synonym: "hypoplastic midbrain" EXACT []
synonym: "mesencephalon hypoplasia" EXACT []
is_a: MP:0012089 ! decreased midbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:32:14Z

[Term]
id: MP:0012091
name: increased midbrain size
def: "greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged mesencephalon" EXACT []
synonym: "enlarged midbrain" EXACT []
synonym: "expanded mesencephalon" EXACT []
synonym: "expanded midbrain" EXACT []
synonym: "increased mesencephalon size" EXACT []
is_a: MP:0005238 ! increased brain size
is_a: MP:0012088 ! abnormal midbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T10:32:14Z

[Term]
id: MP:0012092
name: diencephalon hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the diencephalon, typically resulting in decreased size" [MGI:rbabiuk]
synonym: "betweenbrain hypoplasia" EXACT []
synonym: "hypoplastic diencephalon" EXACT []
synonym: "interbrain hypoplasia" EXACT []
synonym: "thalamencephalon hypoplasia" EXACT []
is_a: MP:0000830 ! abnormal diencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-13T12:57:11Z

[Term]
id: MP:0012093
name: absent nodal flow
def: "absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008933 ! abnormal motile primary cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T11:05:41Z

[Term]
id: MP:0012094
name: abnormal Reichert's membrane thickness
def: "anomaly in the width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003954 ! abnormal Reichert's membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T11:54:48Z

[Term]
id: MP:0012095
name: increased Reichert's membrane thickness
def: "increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased Reichert's membrane width" EXACT []
synonym: "thick Reichert's membrane" EXACT []
synonym: "thickened Reichert's membrane" EXACT []
is_a: MP:0012094 ! abnormal Reichert's membrane thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T11:54:48Z

[Term]
id: MP:0012096
name: decreased Reichert's membrane thickness
def: "reduced width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced Reichert's membrane width" EXACT []
synonym: "thin Reichert's membrane" EXACT []
synonym: "thinned Reichert's membrane" EXACT []
is_a: MP:0012094 ! abnormal Reichert's membrane thickness
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T11:54:48Z

[Term]
id: MP:0012097
name: abnormal spongiotrophoblast size
def: "anomaly in the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004255 ! abnormal spongiotrophoblast layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T13:28:44Z

[Term]
id: MP:0012098
name: increased spongiotrophoblast size
def: "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged spongiotrophoblast layer" EXACT []
synonym: "expanded spongiotrophoblast layer" EXACT []
is_a: MP:0012097 ! abnormal spongiotrophoblast size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T13:28:44Z

[Term]
id: MP:0012099
name: decreased spongiotrophoblast size
def: "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced spongiotrophoblast layer" EXACT []
synonym: "reduced spongiotrophoblast size" EXACT []
synonym: "small spongiotrophoblast layer" EXACT []
is_a: MP:0012097 ! abnormal spongiotrophoblast size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T13:28:44Z

[Term]
id: MP:0012100
name: absent spongiotrophoblast
def: "absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004255 ! abnormal spongiotrophoblast layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T13:28:44Z

[Term]
id: MP:0012101
name: acoria
def: "absence of the pupil of the eye" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent pupil(s)" EXACT []
synonym: "pupil agenesis" EXACT []
is_a: MP:0001317 ! abnormal pupil morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T13:51:03Z

[Term]
id: MP:0012102
name: absent trophectoderm
def: "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent trophectoderm layer" EXACT []
synonym: "failure to form trophectoderm" RELATED []
is_a: MP:0005028 ! abnormal trophectoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T14:13:07Z

[Term]
id: MP:0012103
name: abnormal bilaminar embryonic disk morphology
def: "any structural anomaly of the flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bilaminar embryonic disc morphology" EXACT []
synonym: "abnormal embryonic disc morphology" EXACT []
synonym: "abnormal embryonic disk morphology" EXACT []
synonym: "abnormal embryonic shield morphology" EXACT []
synonym: "abnormal germinal disc morphology" EXACT []
synonym: "abnormal germinal disk morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T14:17:51Z

[Term]
id: MP:0012104
name: small amniotic cavity
def: "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased amniotic cavity size" EXACT []
synonym: "reduced amniotic cavity size" EXACT []
is_a: MP:0011199 ! abnormal amniotic cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T14:26:09Z

[Term]
id: MP:0012105
name: delayed gastrulation
def: "late onset of the development and invagination of the embryonic germ layers" [https://orcid.org/0000-0002-6490-7723]
comment: in the mouse, gastrulation initiates at E6.5, as cells of the primitive ectoderm (epiblast) delaminate at the posterior side of the embryo and ingress through the primitive streak in an epithelial-to-mesenchymal transition
synonym: "retarded gastrulation" EXACT []
is_a: MP:0001695 ! abnormal gastrulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T14:28:59Z

[Term]
id: MP:0012106
name: impaired exercise endurance
def: "impaired performance during controlled physical activity" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased exercise endurance" RELATED []
synonym: "reduced exercise endurance" RELATED []
is_a: MP:0002332 ! abnormal exercise endurance
is_a: MP:0002899 ! fatigue
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T15:23:57Z

[Term]
id: MP:0012107
name: enhanced exercise endurance
def: "improved performance during controlled physical activity" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased exercise endurance" RELATED []
synonym: "prolonged exercise endurance" EXACT []
is_a: MP:0002332 ! abnormal exercise endurance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-23T15:23:57Z

[Term]
id: MP:0012108
name: increased trophoblast glycogen cell number
def: "greater number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008958 ! abnormal trophoblast glycogen cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T15:36:32Z

[Term]
id: MP:0012109
name: decreased trophoblast glycogen cell number
def: "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced trophoblast glycogen cell number" EXACT []
is_a: MP:0008958 ! abnormal trophoblast glycogen cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T15:36:57Z

[Term]
id: MP:0012110
name: increased hair follicle number
def: "greater number of the epidermal invaginations from which the hair shaft develops" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T15:43:53Z

[Term]
id: MP:0012111
name: failure of morula compaction
def: "inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008932 ! abnormal embryonic tissue physiology
is_a: MP:0009781 ! abnormal preimplantation embryo development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T15:58:08Z

[Term]
id: MP:0012112
name: increased inner cell mass proliferation
def: "enhanced expansion rate of the inner cell mass" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced inner cell mass proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0004966 ! abnormal inner cell mass proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:07:00Z

[Term]
id: MP:0012113
name: decreased inner cell mass proliferation
def: "reduced expansion rate of the inner cell mass" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced inner cell mass proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0004966 ! abnormal inner cell mass proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:07:00Z

[Term]
id: MP:0012114
name: absent inner cell mass proliferation
def: "absence of expansion of the inner cell mass" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012113 ! decreased inner cell mass proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:07:00Z

[Term]
id: MP:0012115
name: abnormal trophectoderm cell proliferation
def: "any anomaly in the ability of a trophectoderm cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal trophectodermal cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:08:29Z

[Term]
id: MP:0012116
name: increased trophectoderm cell proliferation
def: "increase in the expansion rate of a trophectoderm cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased trophectodermal cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0012115 ! abnormal trophectoderm cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:09:20Z

[Term]
id: MP:0012117
name: decreased trophectoderm cell proliferation
def: "decrease in the expansion rate of a trophectoderm cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased trophectodermal cell proliferation" EXACT []
synonym: "reduced trophectoderm cell proliferation" EXACT []
synonym: "reduced trophectodermal cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0012115 ! abnormal trophectoderm cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:09:20Z

[Term]
id: MP:0012118
name: absent trophectoderm cell proliferation
def: "failure of a trophectoderm cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent trophectodermal cell proliferation" EXACT []
is_a: MP:0012115 ! abnormal trophectoderm cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:09:20Z

[Term]
id: MP:0012119
name: increased trophectoderm apoptosis
def: "increase in the number of trophectoderm cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
is_a: MP:0006042 ! increased apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:11:22Z

[Term]
id: MP:0012120
name: trophectoderm cell degeneration
def: "a retrogressive impairment of function or destruction of trophectoderm cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-09-26T16:11:22Z

[Term]
id: MP:0012121
name: sclerocornea
def: "a congenital anomaly of the eye in which partial or complete corneal opacity is present and resembles the sclera, with no clear boundary between these structures" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "corneal sclerization" EXACT []
is_a: MP:0001314 ! cornea opacity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T13:42:26Z

[Term]
id: MP:0012122
name: abnormal iris transillumination
def: "any anomaly in the radial light dispersion pattern of the iris when a focused light beam is passed through it; particular dispersion pattern anomalies are indicative of abnormalities in iris pigment distribution and for the presence of glaucoma, atrophy and/or infection" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0001322 ! abnormal iris morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T13:46:24Z

[Term]
id: MP:0012123
name: abnormal bronchoconstrictive response
def: "anomaly in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "abnormal bronchoconstriction response" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T14:12:49Z

[Term]
id: MP:0012124
name: increased bronchoconstrictive response
def: "enhanced or greater than expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "enhanced bronchoconstrictive response" EXACT []
synonym: "increased bronchoconstriction response" EXACT []
is_a: MP:0008873 ! increased physiological sensitivity to xenobiotic
is_a: MP:0012123 ! abnormal bronchoconstrictive response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T14:13:21Z

[Term]
id: MP:0012125
name: decreased bronchoconstrictive response
def: "reduction in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "decreased bronchoconstriction response" EXACT []
synonym: "reduced bronchoconstrictive response" EXACT []
is_a: MP:0008874 ! decreased physiological sensitivity to xenobiotic
is_a: MP:0012123 ! abnormal bronchoconstrictive response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T14:14:14Z

[Term]
id: MP:0012126
name: abnormal placenta hemotrichorial membrane morphology
def: "any structural anomaly of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses" [https://orcid.org/0000-0002-6490-7723]
comment: The human placenta is hemomonochorial, as this membrane consists of a single layer of synctiotrophoblast at term. In mice maternal blood bathes a perforated layer of cytotrophoblast cells that overlay two layers of syncytiotrophoblast, thus the murine placenta is hemotrichorial. Maternal blood has direct access to the murine synctiotrophoblast layer I via fenestrations in the murine cytotrophoblast layer.
synonym: "abnormal placenta haemotrichorial barrier" EXACT []
synonym: "abnormal placenta haemotrichorial layer" EXACT []
synonym: "abnormal placenta haemotrichorial membrane morphology" EXACT []
synonym: "abnormal placenta hemotrichorial barrier" EXACT []
synonym: "abnormal placenta hemotrichorial layer" EXACT []
is_a: MP:0001711 ! abnormal placenta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T14:46:08Z

[Term]
id: MP:0012127
name: absent placenta hemotrichorial membrane
def: "absence of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses" [https://orcid.org/0000-0002-6490-7723]
comment: The human placenta is hemomonochorial, as this membrane consists of a single layer of synctiotrophoblast at term. In mice maternal blood bathes a perforated layer of cytotrophoblast cells that overlay two layers of syncytiotrophoblast, thus the murine placenta is hemotrichorial. Maternal blood has direct access to the murine synctiotrophoblast layer I via fenestrations in the murine cytotrophoblast layer.
synonym: "absent placenta haemotrichorial barrier" EXACT []
synonym: "absent placenta haemotrichorial layer" EXACT []
synonym: "absent placenta haemotrichorial membrane" EXACT []
synonym: "absent placenta hemotrichorial barrier" EXACT []
synonym: "absent placenta hemotrichorial layer" EXACT []
is_a: MP:0012126 ! abnormal placenta hemotrichorial membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T14:48:57Z

[Term]
id: MP:0012128
name: abnormal blastocyst formation
def: "atypical formation of a blastocyst from a solid ball of cells known as a morula, including anomalies in the formation of a fluid-filled cavity (blastocoele) and/or initiation of inner cell mass and trophectoderm differentiation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal blastulation" EXACT []
is_a: MP:0009781 ! abnormal preimplantation embryo development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:17:10Z

[Term]
id: MP:0012129
name: failure of blastocyst formation
def: "inability to form a blastocyst from a solid ball of cells known as a morula" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent blastocyst" EXACT []
is_a: MP:0012128 ! abnormal blastocyst formation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:18:40Z

[Term]
id: MP:0012130
name: abnormal morula formation
def: "atypical formation of the spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal morulation" EXACT []
is_a: MP:0009781 ! abnormal preimplantation embryo development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:44:16Z

[Term]
id: MP:0012131
name: small visceral yolk sac
def: "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [https://orcid.org/0000-0002-6490-7723]
synonym: "small secondary yolk sac" EXACT []
synonym: "small umbilical vesicle" EXACT []
synonym: "small vitelline sac" EXACT []
synonym: "small yolk sac" EXACT []
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:46:33Z

[Term]
id: MP:0012132
name: abnormal midbrain-hindbrain boundary morphology
alt_id: MP:0006174
def: "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal isthmic organizer morphology" EXACT []
synonym: "abnormal isthmomesencephalic boundary morphology" EXACT []
synonym: "abnormal isthmus morphology" EXACT []
synonym: "abnormal isthmus organizer morphology" EXACT []
synonym: "abnormal MHB morphology" EXACT []
synonym: "abnormal midbrain-hindbrain organizer morphology" EXACT []
is_a: MP:0000913 ! abnormal brain development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:52:18Z

[Term]
id: MP:0012133
name: absent midbrain-hindbrain boundary
def: "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent isthmic organizer" EXACT []
synonym: "absent isthmomesencephalic boundary" EXACT []
synonym: "absent isthmus" EXACT []
synonym: "absent isthmus organizer" EXACT []
synonym: "absent MHB" EXACT []
synonym: "absent midbrain-hindbrain organizer" EXACT []
is_a: MP:0012132 ! abnormal midbrain-hindbrain boundary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T15:53:46Z

[Term]
id: MP:0012134
name: absent umbilical cord
def: "absence of or failure to form the connective stalk between the fetus and the placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent chorda umbilicalis" EXACT []
synonym: "absent funiculus umbilicalis" EXACT []
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-08T16:08:33Z

[Term]
id: MP:0012135
name: embryonic-extraembryonic boundary constriction
def: "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003890 ! abnormal embryonic-extraembryonic boundary morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T13:41:19Z

[Term]
id: MP:0012136
name: absent forebrain
def: "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
synonym: "absent prosencephalon" EXACT []
synonym: "forebrain agenesis" EXACT []
synonym: "missing forebrain" EXACT []
synonym: "missing prosencephalon" EXACT []
synonym: "prosencephalon agenesis" EXACT []
is_a: MP:0000783 ! abnormal forebrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T15:20:00Z

[Term]
id: MP:0012137
name: abnormal forebrain size
def: "deviation from the average range of forebrain size compared to normal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal prosencephalon size" EXACT []
is_a: MP:0000771 ! abnormal brain size
is_a: MP:0000783 ! abnormal forebrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T15:20:00Z

[Term]
id: MP:0012138
name: decreased forebrain size
def: "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
synonym: "decreased prosencephalon size" EXACT []
synonym: "reduced forebrain size" EXACT []
synonym: "reduced prosencephalon size" EXACT []
synonym: "small forebrain" EXACT []
synonym: "small prosencephalon" EXACT []
synonym: "truncated forebrain" EXACT []
synonym: "truncated prosencephalon" EXACT []
is_a: MP:0000774 ! decreased brain size
is_a: MP:0012137 ! abnormal forebrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T15:20:00Z

[Term]
id: MP:0012139
name: increased forebrain size
def: "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
synonym: "enlarged forebrain" EXACT []
synonym: "enlarged prosencephalon" EXACT []
synonym: "expanded forebrain" EXACT []
synonym: "expanded prosencephalon" EXACT []
synonym: "increased prosencephalon size" EXACT []
is_a: MP:0005238 ! increased brain size
is_a: MP:0012137 ! abnormal forebrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T15:20:00Z

[Term]
id: MP:0012140
name: forebrain hyperplasia
def: "increase in the number of normal cells in normal arrangement in the forebrain, typically resulting in increased size" [GO:0048853]
synonym: "hyperplastic forebrain" EXACT []
synonym: "hyperplastic prosencephalon" EXACT []
synonym: "prosencephalon hyperplasia" EXACT []
is_a: MP:0012139 ! increased forebrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-09T15:20:00Z

[Term]
id: MP:0012141
name: absent hindbrain
def: "absence of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent rhombencephalon" EXACT []
is_a: MP:0000841 ! abnormal hindbrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-10T15:18:11Z

[Term]
id: MP:0012142
name: absent amniotic cavity
def: "absence of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011199 ! abnormal amniotic cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-10T16:03:38Z

[Term]
id: MP:0012143
name: decreased a-wave amplitude
def: "reduction in the size (height or maximum displacement) of the a-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
synonym: "attenuated a wave amplitude" EXACT []
synonym: "reduced a wave amplitude" EXACT []
is_a: MP:0012030 ! abnormal a-wave amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T12:18:25Z

[Term]
id: MP:0012144
name: decreased b-wave amplitude
def: "reduction in the size (height or maximum displacement) of the b-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
synonym: "attenuated b wave amplitude" EXACT []
synonym: "reduced b wave amplitude" EXACT []
is_a: MP:0012031 ! abnormal b-wave amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T12:19:51Z

[Term]
id: MP:0012145
name: increased a-wave amplitude
def: "increase in the size (height or maximum displacement) of the a-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012030 ! abnormal a-wave amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T12:26:15Z

[Term]
id: MP:0012146
name: increased b-wave amplitude
def: "increase in the size (height or maximum displacement) of the b-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012031 ! abnormal b-wave amplitude
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T12:26:32Z

[Term]
id: MP:0012147
name: increased a-wave implicit time
def: "increase in the time from the onset of light stimulus to the peak of the a-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed a-wave implicit time" EXACT []
synonym: "prolonged a-wave implicit time" EXACT []
is_a: MP:0012038 ! abnormal a-wave implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:02:26Z

[Term]
id: MP:0012148
name: decreased a-wave implicit time
def: "decrease in the time from the onset of light stimulus to the peak of the a-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "faster a-wave implicit time" EXACT []
is_a: MP:0012038 ! abnormal a-wave implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:02:26Z

[Term]
id: MP:0012149
name: decreased b-wave implicit time
def: "decrease in the time from the onset of light stimulus to the peak of the b-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "faster b-wave implicit time" EXACT []
is_a: MP:0012039 ! abnormal b-wave implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:02:53Z

[Term]
id: MP:0012150
name: increased b-wave implicit time
def: "increase in the time from the onset of light stimulus to the peak of the b-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed b-wave implicit time" EXACT []
synonym: "prolonged b-wave implicit time" EXACT []
is_a: MP:0012039 ! abnormal b-wave implicit time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:02:53Z

[Term]
id: MP:0012151
name: increased a-wave latency
def: "increase in the time from onset of stimulus to beginning of the a-wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "prolonged a-wave latency" EXACT []
is_a: MP:0012036 ! abnormal a-wave latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:03:32Z

[Term]
id: MP:0012152
name: decreased a-wave latency
def: "decrease in the time from onset of stimulus to beginning of the a-wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced a-wave latency" EXACT []
is_a: MP:0012036 ! abnormal a-wave latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:03:32Z

[Term]
id: MP:0012153
name: increased b-wave latency
def: "increase in the time from onset of stimulus to beginning of the b-wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "prolonged b-wave latency" EXACT []
is_a: MP:0012037 ! abnormal b-wave latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:04:09Z

[Term]
id: MP:0012154
name: decreased b-wave latency
def: "decrease in the time from onset of stimulus to beginning of the b-wave" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced b-wave latency" EXACT []
is_a: MP:0012037 ! abnormal b-wave latency
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T13:04:09Z

[Term]
id: MP:0012155
name: abnormal optic pit morphology
def: "any structural anomaly of either of the two pits that appear bilaterally in the region destined to become the forebrain as the cranial neural folds fuse; these optic pits or sulci continue to deepen laterally and bulge from the two sides of the forebrain to become the optic vesicles" [https://orcid.org/0000-0002-6490-7723, ISBN:978-0470712306]
synonym: "abnormal optic sulcus morphology" EXACT []
is_a: MP:0003935 ! abnormal craniofacial development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:04:04Z

[Term]
id: MP:0012156
name: rostral-caudal axis duplication
def: "partial or complete duplication of rostral-caudal axis structures" [https://orcid.org/0000-0002-6490-7723]
synonym: "A-P axis duplication" NARROW []
synonym: "anterior-posterior axis duplication" NARROW []
synonym: "head-tail axis duplication" EXACT []
synonym: "rostro-caudal axis duplication" EXACT []
is_a: MP:0005221 ! abnormal rostral-caudal axis patterning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:06:57Z

[Term]
id: MP:0012157
name: rostral body truncation
def: "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [https://orcid.org/0000-0003-3691-0324]
synonym: "anterior body truncation" NARROW []
synonym: "anterior truncation(s)" EXACT []
synonym: "rostral truncation(s)" EXACT []
is_a: MP:0005221 ! abnormal rostral-caudal axis patterning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:08:13Z

[Term]
id: MP:0012158
name: absent visceral endoderm
def: "absence of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011186 ! abnormal visceral endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:18:43Z

[Term]
id: MP:0012159
name: absent anterior visceral endoderm
def: "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008533 ! abnormal anterior visceral endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:19:00Z

[Term]
id: MP:0012160
name: expanded anterior visceral endoderm
def: "the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue occupies a greater area in the extraembryonic region" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad anterior visceral endoderm" EXACT []
is_a: MP:0008533 ! abnormal anterior visceral endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:19:25Z

[Term]
id: MP:0012161
name: absent distal visceral endoderm
def: "absence of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010126 ! abnormal distal visceral endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:19:41Z

[Term]
id: MP:0012162
name: absent parietal endoderm
def: "absence of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011187 ! abnormal parietal endoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-16T14:20:03Z

[Term]
id: MP:0012163
name: abnormal dental mesenchyme morphology
def: "any structural anomaly of the mesenchyme enclosed by dental organ" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal dental organ mesenchyme morophology" EXACT []
synonym: "abnormal enamel organ mesenchyme morophology" EXACT []
synonym: "abnormal odontogenic mesenchyme morophology" EXACT []
synonym: "abnormal tooth enamel organ mesenchyme morophology" EXACT []
synonym: "abnormal tooth mesenchyme morophology" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0011260 ! abnormal head mesenchyme morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-25T07:20:07Z

[Term]
id: MP:0012164
name: abnormal conjunctiva goblet cell morphology
def: "any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal conjunctival goblet cell morphology" EXACT []
is_a: MP:0004481 ! abnormal conjunctival epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-25T07:26:34Z

[Term]
id: MP:0012165
name: absent neural folds
def: "absence of the elevated margins of the neural groove" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011256 ! abnormal neural fold morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-25T08:10:21Z

[Term]
id: MP:0012166
name: absent neural plate
def: "absence of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005657 ! abnormal neural plate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-25T08:10:36Z

[Term]
id: MP:0012167
name: abnormal epigenetic regulation of gene expression
def: "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
is_a: MP:0005621 ! abnormal cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T13:36:59Z

[Term]
id: MP:0012168
name: abnormal optic placode morphology
def: "any structural anomaly of the paired thickenings of surface ectoderm that become invaginated to form the embryonic lens vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lens placode morphology" EXACT []
is_a: MP:0005545 ! abnormal lens development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T15:40:54Z

[Term]
id: MP:0012169
name: optic placode degeneration
def: "a retrogressive impairment of function or destruction of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "lens placode degeneration" EXACT []
is_a: MP:0012168 ! abnormal optic placode morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T15:41:50Z

[Term]
id: MP:0012170
name: absent optic placodes
def: "absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lens placodes" EXACT []
is_a: MP:0012168 ! abnormal optic placode morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T15:41:50Z

[Term]
id: MP:0012171
name: oligohydramnios
def: "presence of an abnormally low amniotic fluid volume in the amniotic sac; the opposite of polyhydramnios" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypamnion" EXACT []
synonym: "hypamnios" EXACT []
synonym: "oligamnios" EXACT []
synonym: "oligoamnios" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T15:58:46Z

[Term]
id: MP:0012172
name: abnormal amniotic fluid composition
def: "any alteration in the expected chemical makeup of the watery liquid within the amnion that surrounds and cushions a growing fetus; normally, early in gestation, amniotic fluid is similar to maternal plasma, mainly water with electrolytes, and later in gestation, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal acqua amnii composition" EXACT []
synonym: "abnormal liquor amnii composition" EXACT []
is_a: MP:0001784 ! abnormal fluid regulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-30T16:03:31Z

[Term]
id: MP:0012173
name: short rostral-caudal axis
def: "length reduction or truncation of the axis that runs from the head to the tail of the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "short A-P axis" EXACT []
synonym: "short anterior-posterior axis" EXACT []
synonym: "short head-tail axis" EXACT []
synonym: "short rostro-caudal axis" EXACT []
synonym: "truncated A-P axis" EXACT []
synonym: "truncated head-tail axis" EXACT []
synonym: "truncated rostral-caudal axis" EXACT []
synonym: "truncated rostro-caudal axis" EXACT []
is_a: MP:0005221 ! abnormal rostral-caudal axis patterning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T11:51:35Z

[Term]
id: MP:0012174
name: flat head
def: "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "flattened head" EXACT []
synonym: "head flattening" EXACT []
is_a: MP:0011495 ! abnormal head shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T12:00:29Z

[Term]
id: MP:0012175
name: flat face
def: "the appearance of a flattened surface outline or contour of a normally rounded face of an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "flattened face" EXACT []
is_a: MP:0030071 ! abnormal face shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T12:23:30Z

[Term]
id: MP:0012176
name: abnormal head development
def: "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
synonym: "abnormal cephalic development" EXACT []
synonym: "abnormal cephalogenesis" EXACT []
is_a: MP:0000432 ! abnormal head morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T12:31:22Z

[Term]
id: MP:0012177
name: delayed head development
def: "late onset of the induction and/or differentiation of the head" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed cephalic development" EXACT []
synonym: "delayed cephalogenesis" EXACT []
synonym: "retarded cephalic development" EXACT []
synonym: "retarded cephalogenesis" EXACT []
synonym: "retarded head development" EXACT []
is_a: MP:0012176 ! abnormal head development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T12:37:57Z

[Term]
id: MP:0012178
name: absent frontonasal prominence
def: "absence of the unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent forebrain process" EXACT []
synonym: "absent forebrain prominence" EXACT []
synonym: "absent frontonasal mass" EXACT []
synonym: "absent frontonasal process" EXACT []
is_a: MP:0009901 ! abnormal frontonasal prominence morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T12:47:28Z

[Term]
id: MP:0012179
name: abnormal splanchnic mesoderm morphology
def: "any structural abnormality of the inner layer of lateral plate mesoderm, located above (dorsally) the endoderm, which forms the circulatory system and future gut wall" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal inner layer of lateral plate mesoderm" EXACT []
synonym: "abnormal splanchnic layer of lateral plate mesoderm" EXACT []
synonym: "abnormal visceral mesoderm morphology" EXACT []
is_a: MP:0010117 ! abnormal lateral plate mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:02:46Z

[Term]
id: MP:0012180
name: abnormal somatic mesoderm morphology
def: "any structural abnormality of the outer layer of lateral plate mesoderm, located under (ventrally) the ectoderm, which forms the future body wall" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal outer layer of lateral plate mesoderm" EXACT []
synonym: "abnormal parietal mesoderm morphology" EXACT []
synonym: "abnormal somatic layer of lateral plate mesoderm" EXACT []
is_a: MP:0010117 ! abnormal lateral plate mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:02:46Z

[Term]
id: MP:0012181
name: increased somite number
def: "increase in the average number of somites formed relative to littermates or other controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "additional somite row(s)" EXACT []
synonym: "extra somite row(s)" EXACT []
synonym: "supernumerary somites" EXACT []
is_a: MP:0001688 ! abnormal somite development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:09:06Z

[Term]
id: MP:0012182
name: abnormal presomitic mesoderm morphology
def: "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal presomitic paraxial mesoderm morphology" EXACT []
synonym: "abnormal PSM morphology" EXACT []
synonym: "abnormal segmental plate morphology" EXACT []
synonym: "abnormal somitogenic mesoderm morphology" EXACT []
synonym: "abnormal unsegmented paraxial mesoderm" EXACT []
is_a: MP:0008029 ! abnormal paraxial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:13:54Z

[Term]
id: MP:0012183
name: decreased paraxial mesoderm size
def: "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased paraxial mesenchyme size" EXACT []
synonym: "decreased somitic mesoderm size" EXACT []
is_a: MP:0008029 ! abnormal paraxial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:17:03Z

[Term]
id: MP:0012184
name: absent paraxial mesoderm
def: "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [https://orcid.org/0000-0002-6490-7723]
synonym: "absent paraxial mesenchyme morphology" EXACT []
synonym: "absent somitic mesoderm" EXACT []
is_a: MP:0008029 ! abnormal paraxial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:17:03Z

[Term]
id: MP:0012185
name: abnormal muscle precursor cell morphology
def: "any structural anomaly of cells that will develop into muscle cells" [https://orcid.org/0000-0003-0431-8641]
synonym: "abnormal muscle progenitor cell morphology" EXACT []
is_a: MP:0000729 ! abnormal myogenesis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:50:52Z

[Term]
id: MP:0012186
name: abnormal muscle precursor cell physiology
def: "anomaly in the function of cells that will develop into muscle cells" [https://orcid.org/0000-0003-0431-8641]
synonym: "abnormal muscle progenitor cell physiology" RELATED []
is_a: MP:0002106 ! abnormal muscle physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T13:51:34Z

[Term]
id: MP:0012187
name: abnormal intraembryonic coelom morphology
def: "any structural anomaly of the part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intraembryonic celom morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:13:33Z

[Term]
id: MP:0012188
name: increased regulatory T cell apoptosis
def: "increase in the number of regulatory T cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004946 ! abnormal regulatory T cell physiology
is_a: MP:0006413 ! increased T cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:21:26Z

[Term]
id: MP:0012189
name: decreased regulatory T cell apoptosis
def: "decrease in the number of regulatory T cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004946 ! abnormal regulatory T cell physiology
is_a: MP:0006414 ! decreased T cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:22:14Z

[Term]
id: MP:0012190
name: increased cytotoxic T cell apoptosis
def: "increase in the number of cytotoxic T cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005078 ! abnormal cytotoxic T cell physiology
is_a: MP:0006413 ! increased T cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:25:11Z

[Term]
id: MP:0012191
name: decreased cytotoxic T cell apoptosis
def: "decrease in the number of cytotoxic T cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cytotoxic T cell apoptosis" EXACT []
is_a: MP:0005078 ! abnormal cytotoxic T cell physiology
is_a: MP:0006414 ! decreased T cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:25:11Z

[Term]
id: MP:0012192
name: abnormal keratinocyte migration
def: "anomaly in the movement of keratinocyes or their precursors to the appropriate location in the body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0003453 ! abnormal keratinocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:29:41Z

[Term]
id: MP:0012193
name: increased keratinocyte migration
def: "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011804 ! increased cell migration
is_a: MP:0012192 ! abnormal keratinocyte migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:30:01Z

[Term]
id: MP:0012194
name: decreased keratinocyte migration
def: "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011805 ! decreased cell migration
is_a: MP:0012192 ! abnormal keratinocyte migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:30:10Z

[Term]
id: MP:0012195
name: impaired neural crest cell differentiation
def: "abnormal or arrest of differentiation of the transient and highly migratory group of cells that delaminate in early embryonic development from the dorsal neural tube and give rise to a variety of differentiated cell types" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:38:34Z

[Term]
id: MP:0012196
name: abnormal myofibroblast differentiation
def: "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myofibroblast, a cell that has characteristics of both a fibroblast cell and a smooth muscle cell and is reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha" [CL:0000186]
synonym: "abnormal MFB differentiation" EXACT []
is_a: MP:0005076 ! abnormal cell differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:41:46Z

[Term]
id: MP:0012197
name: impaired myofibroblast differentiation
def: "reduced ability or inability to produce myofibroblasts, cells that have characteristics of both a fibroblast cell and a smooth muscle cell and are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha" [CL:0000186]
synonym: "impaired MFB differentiation" EXACT []
is_a: MP:0012196 ! abnormal myofibroblast differentiation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:42:09Z

[Term]
id: MP:0012198
name: absent interphalangeal joint
def: "absence of a hinge joint(s) that connects one phalanx to another along a proximodistal axis" [UBERON:0006658]
synonym: "absent interphalangeal articulations" EXACT []
is_a: MP:0012199 ! abnormal interphalangeal joint morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:43:37Z

[Term]
id: MP:0012199
name: abnormal interphalangeal joint morphology
def: "any structural anomaly of a hinge joint that connects one phalanx to another along a proximodistal axis" [UBERON:0006658]
synonym: "abnormal interphalangeal articulation morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030806 ! abnormal autopod joint morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:43:37Z

[Term]
id: MP:0012200
name: increased endothelial cell proliferation
def: "greater expansion rate of a endothelial cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0012202 ! abnormal endothelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:45:14Z

[Term]
id: MP:0012201
name: decreased endothelial cell proliferation
def: "reduction in the expansion rate of a endothelial cell population by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0012202 ! abnormal endothelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:45:14Z

[Term]
id: MP:0012202
name: abnormal endothelial cell proliferation
def: "anomaly in the ability of an endothelial cell population to undergo expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000350 ! abnormal cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:45:14Z

[Term]
id: MP:0012203
name: abnormal neuronal stem cell morphology
def: "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
synonym: "abnormal neural stem cell morphology" EXACT []
is_a: MP:0003861 ! abnormal nervous system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:55:58Z

[Term]
id: MP:0012204
name: abnormal neuronal stem cell physiology
def: "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
synonym: "abnormal neural stem cell physiology" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:57:22Z

[Term]
id: MP:0012205
name: abnormal neuronal stem cell self-renewal
def: "any anomaly in the process by which stem cells divide and proliferate to make more stem cells, perpetuating the stem cell pool; self-renewal is division with maintenance of the undifferentiated state" [PMID:19575646]
synonym: "abnormal neural stem cell proliferation" EXACT []
synonym: "abnormal neural stem cell self-renewal" EXACT []
synonym: "abnormal neuronal stem cell proliferation" EXACT []
is_a: MP:0012204 ! abnormal neuronal stem cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:58:23Z

[Term]
id: MP:0012206
name: increased neuronal stem cell self-renewal
def: "an increased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an increase in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state" [PMID:19575646]
synonym: "increased neural stem cell proliferation" EXACT []
synonym: "increased neural stem cell self-renewal" EXACT []
synonym: "increased neuronal stem cell proliferation" EXACT []
is_a: MP:0012205 ! abnormal neuronal stem cell self-renewal
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:58:23Z

[Term]
id: MP:0012207
name: decreased neuronal stem cell self-renewal
def: "a decreased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an decrease in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state" [PMID:19575646]
synonym: "decreased neural stem cell proliferation" EXACT []
synonym: "decreased neural stem cell self-renewal" EXACT []
synonym: "decreased neuronal stem cell proliferation" EXACT []
is_a: MP:0012205 ! abnormal neuronal stem cell self-renewal
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-10-31T14:58:23Z

[Term]
id: MP:0012208
name: abnormal hypoxanthine-guanine phosphoribosyltransferase level
def: "altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "abnormal 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "abnormal 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "abnormal GMP pyrophosphorylase level" EXACT []
synonym: "abnormal GPRT level" EXACT []
synonym: "abnormal guanine phosphoribosyltransferase level" EXACT []
synonym: "abnormal guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "abnormal guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "abnormal guanosine phosphoribosyltransferase level" EXACT []
synonym: "abnormal guanylate pyrophosphorylase level" EXACT []
synonym: "abnormal guanylic pyrophosphorylase level" EXACT []
synonym: "abnormal HGPRT level" EXACT []
synonym: "abnormal HGPRTase level" EXACT []
synonym: "abnormal HPRT level" EXACT []
synonym: "abnormal IMP pyrophosphorylase level" EXACT []
synonym: "abnormal IMP-GMP pyrophosphorylase level" EXACT []
synonym: "abnormal inosinate pyrophosphorylase level" EXACT []
synonym: "abnormal inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "abnormal inosinic acid pyrophosphorylase level" EXACT []
synonym: "abnormal inosinic pyrophosphorylase level" EXACT []
synonym: "abnormal purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "abnormal transphosphoribosidase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012209
name: decreased hypoxanthine-guanine phosphoribosyltransferase level
def: "reduced level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "decreased 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "decreased 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "decreased GMP pyrophosphorylase level" EXACT []
synonym: "decreased GPRT level" EXACT []
synonym: "decreased guanine phosphoribosyltransferase level" EXACT []
synonym: "decreased guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "decreased guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased guanosine phosphoribosyltransferase level" EXACT []
synonym: "decreased guanylate pyrophosphorylase level" EXACT []
synonym: "decreased guanylic pyrophosphorylase level" EXACT []
synonym: "decreased HGPRT level" EXACT []
synonym: "decreased HGPRTase level" EXACT []
synonym: "decreased HPRT level" EXACT []
synonym: "decreased IMP pyrophosphorylase level" EXACT []
synonym: "decreased IMP-GMP pyrophosphorylase level" EXACT []
synonym: "decreased inosinate pyrophosphorylase level" EXACT []
synonym: "decreased inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased inosinic acid pyrophosphorylase level" EXACT []
synonym: "decreased inosinic pyrophosphorylase level" EXACT []
synonym: "decreased purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "decreased transphosphoribosidase level" EXACT []
synonym: "reduced HGPRT level" EXACT []
synonym: "reduced hypoxanthine-guanine phosphoribosyltransferase level" EXACT []
is_a: MP:0012208 ! abnormal hypoxanthine-guanine phosphoribosyltransferase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012210
name: increased hypoxanthine-guanine phosphoribosyltransferase level
def: "greater level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "increased 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "increased 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "increased GMP pyrophosphorylase level" EXACT []
synonym: "increased GPRT level" EXACT []
synonym: "increased guanine phosphoribosyltransferase level" EXACT []
synonym: "increased guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "increased guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "increased guanosine phosphoribosyltransferase level" EXACT []
synonym: "increased guanylate pyrophosphorylase level" EXACT []
synonym: "increased guanylic pyrophosphorylase level" EXACT []
synonym: "increased HGPRT level" EXACT []
synonym: "increased HGPRTase level" EXACT []
synonym: "increased HPRT level" EXACT []
synonym: "increased IMP pyrophosphorylase level" EXACT []
synonym: "increased IMP-GMP pyrophosphorylase level" EXACT []
synonym: "increased inosinate pyrophosphorylase level" EXACT []
synonym: "increased inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "increased inosinic acid pyrophosphorylase level" EXACT []
synonym: "increased inosinic pyrophosphorylase level" EXACT []
synonym: "increased purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "increased transphosphoribosidase level" EXACT []
is_a: MP:0012208 ! abnormal hypoxanthine-guanine phosphoribosyltransferase level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012211
name: decreased thalamus hypoxanthine-guanine phosphoribosyltransferase level
def: "reduced level in the thalamus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "decreased thalamus 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus GMP pyrophosphorylase level" EXACT []
synonym: "decreased thalamus GPRT level" EXACT []
synonym: "decreased thalamus guanine phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased thalamus guanosine phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus guanylate pyrophosphorylase level" EXACT []
synonym: "decreased thalamus guanylic pyrophosphorylase level" EXACT []
synonym: "decreased thalamus HGPRT level" EXACT []
synonym: "decreased thalamus HGPRTase level" EXACT []
synonym: "decreased thalamus HPRT level" EXACT []
synonym: "decreased thalamus IMP pyrophosphorylase level" EXACT []
synonym: "decreased thalamus IMP-GMP pyrophosphorylase level" EXACT []
synonym: "decreased thalamus inosinate pyrophosphorylase level" EXACT []
synonym: "decreased thalamus inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased thalamus inosinic acid pyrophosphorylase level" EXACT []
synonym: "decreased thalamus inosinic pyrophosphorylase level" EXACT []
synonym: "decreased thalamus purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "decreased thalamus transphosphoribosidase level" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
is_a: MP:0012209 ! decreased hypoxanthine-guanine phosphoribosyltransferase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012212
name: increased thalamus hypoxanthine-guanine phosphoribosyltransferase level
def: "greater level in the thalmus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "increased thalamus 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus GMP pyrophosphorylase level" EXACT []
synonym: "increased thalamus GPRT level" EXACT []
synonym: "increased thalamus guanine phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "increased thalamus guanosine phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus guanylate pyrophosphorylase level" EXACT []
synonym: "increased thalamus guanylic pyrophosphorylase level" EXACT []
synonym: "increased thalamus HGPRT level" EXACT []
synonym: "increased thalamus HGPRTase level" EXACT []
synonym: "increased thalamus HPRT level" EXACT []
synonym: "increased thalamus IMP pyrophosphorylase level" EXACT []
synonym: "increased thalamus IMP-GMP pyrophosphorylase level" EXACT []
synonym: "increased thalamus inosinate pyrophosphorylase level" EXACT []
synonym: "increased thalamus inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "increased thalamus inosinic acid pyrophosphorylase level" EXACT []
synonym: "increased thalamus inosinic pyrophosphorylase level" EXACT []
synonym: "increased thalamus purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "increased thalamus transphosphoribosidase level" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
is_a: MP:0012210 ! increased hypoxanthine-guanine phosphoribosyltransferase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012213
name: decreased hypothalamus hypoxanthine-guanine phosphoribosyltransferase level
def: "reduced level in the hypothalamus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "decreased hypothalamus 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus GMP pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus GPRT level" EXACT []
synonym: "decreased hypothalamus guanine phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus guanosine phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus guanylate pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus guanylic pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus HGPRT level" EXACT []
synonym: "decreased hypothalamus HGPRTase level" EXACT []
synonym: "decreased hypothalamus HPRT level" EXACT []
synonym: "decreased hypothalamus IMP pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus IMP-GMP pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus inosinate pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus inosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus inosinic acid pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus inosinic pyrophosphorylase level" EXACT []
synonym: "decreased hypothalamus purine-6-thiol phosphoribosyltransferase level" EXACT []
synonym: "decreased hypothalamus transphosphoribosidase level" EXACT []
synonym: "reduced hypothalamus HGPRT level" EXACT []
synonym: "reduced hypothalamus hypoxanthine-guanine phosphoribosyltransferase level" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology
is_a: MP:0012209 ! decreased hypoxanthine-guanine phosphoribosyltransferase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012214
name: increased hypothalamus hypoxanthine-guanine phosphoribosyltransferase level
def: "greater level in the hypothalmus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate" [ISBN:0-683-40008-8]
synonym: "increased hypothalamus 6-hydroxypurine phosphoribosyltransferase level" EXACT []
synonym: "increased hypothalamus 6-mercaptopurine phosphoribosyltransferase level" EXACT []
synonym: "increased hypothalamus GMP pyrophosphorylase level" EXACT []
synonym: "increased hypothalamus GPRT level" EXACT []
synonym: "increased hypothalamus guanine phosphoribosyltransferase level" EXACT []
synonym: "increased hypothalamus guanine-hypoxanthine phosphoribosyltransferase level" EXACT []
synonym: "increased hypothalamus guanosine 5'-phosphate pyrophosphorylase level" EXACT []
synonym: "increased hypothalamus guanosine phosphoribosyltransferase level" EXACT []
synonym: "increased hypothalamus guanylate pyrophosphorylase level" EXACT []
synonym: "increased hypothalamus guanylic pyrophosphorylase level" EXACT []
synonym: "increased hypothalamus HGPRT level" EXACT []
synonym: "increased hypothalamus HGPRTase level" EXACT []
synonym: "increased hypothalamus HPRT level" EXACT []
synonym: "increased hypoxanthine-guanine phosphoribosyltransferase level in hypothalamus" EXACT []
synonym: "increased IMP pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased IMP-GMP pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased inosinate pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased inosine 5'-phosphate pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased inosinic acid pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased inosinic pyrophosphorylase level in hypothalamus" EXACT []
synonym: "increased purine-6-thiol phosphoribosyltransferase level in hypothalamus" EXACT []
synonym: "increased transphosphoribosidase level in hypothalamus" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology
is_a: MP:0012210 ! increased hypoxanthine-guanine phosphoribosyltransferase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-10T20:12:53Z

[Term]
id: MP:0012215
name: abnormal plasmalogen level
def: "anomaly in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
is_a: MP:0012220 ! abnormal ether lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:06:04Z

[Term]
id: MP:0012216
name: decreased plasmalogen level
def: "reduction in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
synonym: "reduced plasmalogen level" EXACT []
is_a: MP:0012215 ! abnormal plasmalogen level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:06:04Z

[Term]
id: MP:0012217
name: increased plasmalogen level
def: "greater amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
is_a: MP:0012215 ! abnormal plasmalogen level
is_a: MP:0014460 ! increased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:06:04Z

[Term]
id: MP:0012218
name: decreased brain plasmalogen level
def: "reduction in the amount in the brain of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
synonym: "reduced brain plasmalogen level" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0012216 ! decreased plasmalogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:06:04Z

[Term]
id: MP:0012219
name: increased brain plasmalogen level
def: "greater amount in the brain of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0012217 ! increased plasmalogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:06:04Z

[Term]
id: MP:0012220
name: abnormal ether lipid level
def: "anomaly in the amount of lipids in which one or more of the carbon atoms on glycerol is bonded to an alkyl chain via an ether linkage, as opposed to the usual ester linkage" [CHEBI:64611, PMID:22771767]
synonym: "abnormal ether glycerolipid level" EXACT []
synonym: "abnormal ether phospholipid level" EXACT []
is_a: MP:0004777 ! abnormal phospholipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T10:36:31Z

[Term]
id: MP:0012221
name: abnormal circulating prothrombin level
def: "anomaly in the blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal Cf2 level" EXACT []
synonym: "abnormal cogulation factor II level" EXACT []
synonym: "abnormal prothrombin level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T11:02:44Z

[Term]
id: MP:0012222
name: decreased circulating prothrombin level
def: "reduction in the blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased Cf2 level" EXACT []
synonym: "decreased cogulation factor II level" EXACT []
synonym: "decreased prothrombin level" EXACT []
synonym: "reduced Cf2 level" EXACT []
synonym: "reduced cogulation factor II level" EXACT []
synonym: "reduced prothrombin level" EXACT []
is_a: MP:0012221 ! abnormal circulating prothrombin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T11:03:18Z

[Term]
id: MP:0012223
name: increased circulating prothrombin level
def: "greater blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased Cf2 level" EXACT []
synonym: "increased cogulation factor II level" EXACT []
synonym: "increased prothrombin level" EXACT []
is_a: MP:0012221 ! abnormal circulating prothrombin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T11:03:18Z

[Term]
id: MP:0012224
name: abnormal sterol level
def: "anomaly in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal steroid alcohol level" EXACT []
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T12:29:35Z

[Term]
id: MP:0012225
name: decreased sterol level
def: "reduction in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased steroid alcohol level" EXACT []
synonym: "reduced steroid alcohol level" EXACT []
synonym: "reduced sterol level" EXACT []
is_a: MP:0012224 ! abnormal sterol level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T12:35:54Z

[Term]
id: MP:0012226
name: increased sterol level
def: "greater level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased steroid alcohol level" EXACT []
is_a: MP:0012224 ! abnormal sterol level
is_a: MP:0014460 ! increased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T12:35:54Z

[Term]
id: MP:0012227
name: decreased brain sterol level
def: "reduced level in the brain of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased brain steroid alcohol level" EXACT []
synonym: "reduced brain steroid alcohol level" EXACT []
synonym: "reduced brain sterol level" EXACT []
is_a: MP:0012225 ! decreased sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T12:35:54Z

[Term]
id: MP:0012228
name: increased brain sterol level
def: "greater level in the brain of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased brain steroid alcohol level" EXACT []
is_a: MP:0012226 ! increased sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T12:35:54Z

[Term]
id: MP:0012229
name: abnormal sulfoglycosphingolipid level
def: "anomaly in the concentration or amount of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide]
synonym: "abnormal sulfatide level" EXACT []
is_a: MP:0012233 ! abnormal acidic glycosphingolipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T13:58:55Z

[Term]
id: MP:0012230
name: abnormal sphingolipid level
def: "anomaly in the amount of any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)" [GO:0030148]
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T14:58:50Z

[Term]
id: MP:0012231
name: abnormal ganglioside level
def: "any anomaly in the concentration of the molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain" [CHEBI:28892]
is_a: MP:0012232 ! abnormal ceramide level
is_a: MP:0012233 ! abnormal acidic glycosphingolipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T15:00:30Z

[Term]
id: MP:0012232
name: abnormal ceramide level
def: "any anomaly in the concentration of the subclass of sphingoid base derivatives with an amide-linked fatty acid, where the fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms" [CHEBI:17761, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012230 ! abnormal sphingolipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T15:00:49Z

[Term]
id: MP:0012233
name: abnormal acidic glycosphingolipid level
def: "anomaly in the amount of any of a subclass of glycosphingolipids that contain large polar heads composed of several sugar units and have one or more of their terminal sugar units bound to a negatively charged molecule at pH 7; negative charges can be provided by sialic acids (gangliosides), uronic acids (uronoglycosphingolipids), sulfates (sulfoglycosphingolipids), phosphates (phosphoglycosphingolipids), and phosphonates (phosphonoglycosphingolipids)" [https://connects.catalyst.harvard.edu/Profiles/display/Concept/Acidic%20Glycosphingolipids, ISBN:9780444527462]
is_a: MP:0020194 ! abnormal glycosphingolipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-11T15:07:07Z

[Term]
id: MP:0012234
name: abnormal hepatic diverticulum morphology
def: "any structural anomaly of the out-pocket of thickened ventral foregut epithelium adjacent to the developing heart that constitutes the first morphological sign of the embryonic liver" [https://orcid.org/0000-0002-6490-7723]
comment: In mice, the hepatic diverticulum forms by E9 and expands into an obvious liver bud by E10. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, whereas the posterior portion forms the gall bladder and the extrahepatic bile ducts.
synonym: "abnormal diverticulum hepaticum morphology" EXACT []
synonym: "abnormal liver diverticulum morphology" EXACT []
is_a: MP:0003943 ! abnormal hepatobiliary system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T09:45:29Z

[Term]
id: MP:0012235
name: abnormal liver bud morphology
def: "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [https://orcid.org/0000-0002-6490-7723]
comment: In the mouse, between E9.5 and E15, the liver bud undergoes significant growth and, following invasion of hematopoietic cells, becomes the primary site of fetal hematopoiesis.
synonym: "abnormal embryological hepatic plate" EXACT []
synonym: "abnormal hepatic bud morphology" EXACT []
synonym: "abnormal liver primordium morphology" EXACT []
is_a: MP:0000596 ! abnormal liver development
is_a: MP:0012234 ! abnormal hepatic diverticulum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T09:45:29Z

[Term]
id: MP:0012236
name: abnormal cholangiocyte morphology
def: "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
synonym: "abnormal epithelial cell of bile duct morphology" NARROW []
is_a: MP:0002928 ! abnormal bile duct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T10:14:03Z

[Term]
id: MP:0012237
name: increased cholangiocyte apoptosis
def: "increase in the number of epithelial cells of the bile duct undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased epithelial cell of bile duct apoptosis" BROAD []
is_a: MP:0003252 ! abnormal bile duct physiology
is_a: MP:0006042 ! increased apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T11:49:20Z

[Term]
id: MP:0012238
name: abnormal cholangiocyte primary cilium morphology
def: "any structural anomaly of the primary cilia found on the epithelial cells of the bile duct and extending from their apical membrane into the ductal lumen" [https://orcid.org/0000-0002-6490-7723, PMID:18024594]
synonym: "abnormal cholangiocyte cilia" EXACT []
is_a: MP:0012236 ! abnormal cholangiocyte morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T11:50:37Z

[Term]
id: MP:0012239
name: abnormal cholangiocyte primary cilium physiology
def: "any functional anomaly of the primary cilia found on the epithelial cells of the bile duct and extending from their apical membrane into the ductal lumen; cholangiocyte cilia respond to mechanical stimuli (i.e. luminal fluid flow) by alterations in intracellular Ca2+ and cAMP and are thought to act as osmosensors that play an important role in ductal bile formation by detecting changes in luminal tonicity and inducing bicarbonate secretion" [https://orcid.org/0000-0002-6490-7723, PMID:18024594]
is_a: MP:0003252 ! abnormal bile duct physiology
is_a: MP:0013211 ! abnormal nonmotile primary cilium physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T11:51:33Z

[Term]
id: MP:0012240
name: abnormal hepatoblast morphology
def: "any structural anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003943 ! abnormal hepatobiliary system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T12:58:02Z

[Term]
id: MP:0012241
name: abnormal hepatoblast physiology
def: "any functional anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002139 ! abnormal hepatobiliary system physiology
is_a: MP:0005621 ! abnormal cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T12:59:57Z

[Term]
id: MP:0012242
name: abnormal hepatoblast differentiation
def: "developmental anomaly or inability of hepatoblasts to differentiate into hepatocytes and cholangiocytes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012240 ! abnormal hepatoblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T13:01:20Z

[Term]
id: MP:0012243
name: decreased hepatoblast number
def: "reduced number of the bi-potent cells that retain the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012240 ! abnormal hepatoblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T13:01:52Z

[Term]
id: MP:0012244
name: increased hepatoblast apoptosis
def: "increase in the number of hepatoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0012241 ! abnormal hepatoblast physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T13:02:15Z

[Term]
id: MP:0012245
name: abnormal hepatoblast migration
def: "atypical migration of hepatoblasts across the basement membrane of the liver bud and/or invasion of the neighboring septum transversum mesenchyme" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0012241 ! abnormal hepatoblast physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T13:02:40Z

[Term]
id: MP:0012246
name: abnormal hepatic cord morphology
def: "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hepatic lamina morphology" EXACT []
synonym: "abnormal hepatic laminae" EXACT []
synonym: "abnormal lamina hepatica morphology" EXACT []
synonym: "abnormal liver cell plate morphology" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T13:06:35Z

[Term]
id: MP:0012247
name: absent cornea
def: "absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cornea of camera-type eye" EXACT []
synonym: "absent tunica cornea" EXACT []
synonym: "cornea agenesis" EXACT []
synonym: "cornea aplasia" EXACT []
synonym: "corneal agenesis" EXACT []
synonym: "corneal aplasia" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T15:38:48Z

[Term]
id: MP:0012248
name: absent dermatome
def: "absence of the mesoderm that is derived from the somite that is fated to become the dermis" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cutis plate" EXACT []
synonym: "absent dermatomal mesenchyme" EXACT []
is_a: MP:0003940 ! abnormal dermatome morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T15:45:11Z

[Term]
id: MP:0012249
name: absent myotome
def: "absence of the mesoderm that is derived from the somite that is fated to become the musculature" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent muscle plate" EXACT []
synonym: "absent myomere(s)" EXACT []
is_a: MP:0003939 ! abnormal myotome morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T15:46:39Z

[Term]
id: MP:0012250
name: absent heart valves
def: "failure to form all of the membranous folds of the heart that prevent reflux of fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cardiac valves" EXACT []
synonym: "cardiac valve agenesis" EXACT []
synonym: "cardiac valve aplasia" EXACT []
synonym: "heart valve agenesis" EXACT []
synonym: "heart valve aplasia" EXACT []
is_a: MP:0000285 ! abnormal heart valve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-12T15:54:11Z

[Term]
id: MP:0012251
name: abnormal diaphragm development
def: "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000733 ! abnormal muscle development
is_a: MP:0002279 ! abnormal diaphragm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T12:47:25Z

[Term]
id: MP:0012252
name: abnormal septum transversum morphology
def: "any structural anomaly of the thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions; the cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm, and the caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut" [https://orcid.org/0000-0002-6490-7723, VHOG:0000019]
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T12:52:37Z

[Term]
id: MP:0012253
name: abnormal intersomitic vessel morphology
def: "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intersegmental vessel morphology" EXACT []
synonym: "abnormal intersomitic blood vessel morphology" EXACT []
synonym: "abnormal intersomitic vasculature" EXACT []
synonym: "abnormal segmental vessel morphology" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T12:57:41Z

[Term]
id: MP:0012254
name: absent intersomitic vessels
def: "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent intersegmental vessels" EXACT []
synonym: "absent intersomitic blood vessels" EXACT []
synonym: "absent intersomitic vasculature" EXACT []
synonym: "absent segmental vessels" EXACT []
is_a: MP:0012253 ! abnormal intersomitic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T13:02:49Z

[Term]
id: MP:0012255
name: abnormal intersomitic vein morphology
def: "any structural anomaly of the vein that sprouts from the posterior cardinal vein, growing dorsally between the somites, and then joining, and draining the dorsal longitudinal anastomosing vessel" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intersegmental vein morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology
is_a: MP:0012253 ! abnormal intersomitic vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T13:06:24Z

[Term]
id: MP:0012256
name: abnormal philtrum morphology
def: "any structural anomaly of the vertical groove found on the median line of the upper lip" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012523 ! abnormal upper lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T13:52:37Z

[Term]
id: MP:0012257
name: absent philtrum
def: "absence of the vertical groove normally found on the median line of the upper lip" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012256 ! abnormal philtrum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T13:52:37Z

[Term]
id: MP:0012258
name: philtrum hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the philtrum, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic philtrum" EXACT []
is_a: MP:0012256 ! abnormal philtrum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T13:52:37Z

[Term]
id: MP:0012259
name: meningocele
def: "a protrusion of meninges through one or more defects in the the skull or spinal column, resulting in a cyst filled with cerebrospinal fluid; nervous tissue remains unaffected" [https://orcid.org/0000-0003-4606-0597, ISBN:0-8036-0655-9]
synonym: "meningeal cyst" EXACT []
is_a: MP:0000929 ! open neural tube
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T14:19:37Z

[Term]
id: MP:0012260
name: encephalomeningocele
alt_id: MP:0010083
def: "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occurring in the occipital region" [ISBN:0-683-40008-8]
synonym: "bifid cranium" EXACT []
synonym: "craniocele" EXACT []
synonym: "craniocoele" EXACT []
synonym: "cranium bifidum" EXACT []
synonym: "encephalocele" EXACT []
synonym: "encephalocoele" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-13T15:34:27Z

[Term]
id: MP:0012261
name: increased hindbrain apoptosis
def: "increase in the number of cells of the hindbrain undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased rhombencephalon apoptosis" EXACT []
is_a: MP:0014178 ! increased brain apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:48:12Z

[Term]
id: MP:0012262
name: abnormal hindbrain size
def: "deviation from the average range of hindbrain size compared to normal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal rhombencephalon size" EXACT []
is_a: MP:0000771 ! abnormal brain size
is_a: MP:0000841 ! abnormal hindbrain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:52:00Z

[Term]
id: MP:0012263
name: decreased hindbrain size
def: "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased rhombencephalon size" EXACT []
synonym: "reduced hindbrain size" EXACT []
synonym: "reduced rhombencephalon size" EXACT []
synonym: "small hindbrain" EXACT []
synonym: "small rhombencephalon" EXACT []
synonym: "truncated hindbrain" EXACT []
synonym: "truncated rhombencephalon" EXACT []
is_a: MP:0012262 ! abnormal hindbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:53:41Z

[Term]
id: MP:0012264
name: hindbrain hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the hindbrain, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic hindbrain" EXACT []
synonym: "hypoplastic rhombencephalon" EXACT []
synonym: "rhombencephalon hypoplasia" EXACT []
is_a: MP:0012263 ! decreased hindbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:53:41Z

[Term]
id: MP:0012265
name: increased hindbrain size
def: "greater than average size of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged hindbrain" EXACT []
synonym: "enlarged rhombencephalon" EXACT []
synonym: "expanded hindbrain" EXACT []
synonym: "expanded rhombencephalon" EXACT []
synonym: "increased rhombencephalon size" EXACT []
is_a: MP:0012262 ! abnormal hindbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:53:41Z

[Term]
id: MP:0012266
name: hindbrain hyperplasia
def: "increase in the number of normal cells in normal arrangement in the hindbrain, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic hindbrain" EXACT []
synonym: "hyperplastic rhombencephalon" EXACT []
synonym: "rhombencephalon hyperplasia" EXACT []
is_a: MP:0012265 ! increased hindbrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T09:53:41Z

[Term]
id: MP:0012267
name: abnormal red nucleus morphology
def: "any anomaly of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [https://orcid.org/0000-0002-6490-7723]
comment: The red nucleus comprises a caudal magnocellular and a rostral parvocellular part. The red nucleus and substantia nigra are subcortical centers of the extrapyramidal motor system. In vertebrates without a significant corticospinal tract, gait is mainly controlled by the red nucleus.
synonym: "abnormal nucleus ruber morphology" EXACT []
synonym: "abnormal nucleus ruber tegmenti morphology" EXACT []
is_a: MP:0006100 ! abnormal tegmentum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T10:20:32Z

[Term]
id: MP:0012268
name: absent red nucleus
def: "absence of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent nucleus ruber" EXACT []
synonym: "absent nucleus ruber tegmenti" EXACT []
is_a: MP:0012267 ! abnormal red nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T10:24:22Z

[Term]
id: MP:0012269
name: nuchal edema
def: "abnormal accumulation of subcutaneous fluid in the nuchal region i.e. at the back of the neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "nuchal oedema" EXACT []
synonym: "posterior cervical edema" EXACT []
synonym: "posterior cervical oedema" EXACT []
is_a: MP:0001786 ! skin edema
is_a: MP:0012723 ! abnormal nuchal region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T10:33:36Z

[Term]
id: MP:0012270
name: cardiac edema
def: "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [https://orcid.org/0000-0002-6490-7723]
synonym: "cardiac oedema" EXACT []
is_a: MP:0001785 ! edema
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T10:55:14Z

[Term]
id: MP:0012271
name: abnormal chordamesoderm morphology
def: "any structural anomaly of the area of axial mesoderm that develops into the notochord" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal axial chorda mesoderm morphology" EXACT []
synonym: "abnormal chorda mesoderm morphology" EXACT []
synonym: "abnormal chordomesoderm morphology" EXACT []
synonym: "abnormal presumptive notochord morphology" EXACT []
is_a: MP:0001684 ! abnormal axial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:42:10Z

[Term]
id: MP:0012272
name: decreased axial mesoderm size
def: "reduced size or deficiency of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [https://orcid.org/0000-0002-6490-7723]
synonym: "deficient axial mesoderm" EXACT []
synonym: "reduced axial mesoderm size" EXACT []
is_a: MP:0001684 ! abnormal axial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:49:43Z

[Term]
id: MP:0012273
name: axial mesoderm hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the axial mesoderm, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic axial mesoderm" EXACT []
is_a: MP:0012272 ! decreased axial mesoderm size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:49:43Z

[Term]
id: MP:0012274
name: increased axial mesoderm size
def: "greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [https://orcid.org/0000-0002-6490-7723]
synonym: "expanded axial mesoderm" EXACT []
is_a: MP:0001684 ! abnormal axial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:49:43Z

[Term]
id: MP:0012275
name: abnormal prechordal mesoderm morphology
def: "any structural anomaly of the area of axial mesoderm that develops into the prechordal plate" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001684 ! abnormal axial mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:55:40Z

[Term]
id: MP:0012276
name: absent prechordal mesoderm
def: "absence of or failure to form the area of axial mesoderm that develops into the prechordal plate" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012275 ! abnormal prechordal mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:56:18Z

[Term]
id: MP:0012277
name: increased tail bud apoptosis
def: "increased number of cells undergoing programmed cell death in the primordial region of the embryo that arises to form the tail of the adult" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T11:58:55Z

[Term]
id: MP:0012278
name: abnormal cardiogenic mesoderm morphology
def: "any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac mesoderm morphology" EXACT []
synonym: "abnormal cardiac mesoderm primordium morphology" EXACT []
is_a: MP:0002925 ! abnormal cardiovascular development
is_a: MP:0014141 ! abnormal mesoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:10:07Z

[Term]
id: MP:0012279
name: wide sternum
def: "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad breastbone" EXACT []
synonym: "broad sternum" EXACT []
synonym: "increased sternum width" EXACT []
synonym: "wide breastbone" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:28:27Z

[Term]
id: MP:0012280
name: abnormal sternebra size
def: "atypical size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004322 ! abnormal sternebra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:32:20Z

[Term]
id: MP:0012281
name: decreased sternebra size
def: "reduced average size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced sternebra size" EXACT []
synonym: "small sternebra" EXACT []
is_a: MP:0012280 ! abnormal sternebra size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:32:20Z

[Term]
id: MP:0012282
name: abnormal sternebra number
def: "deviation from the average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004322 ! abnormal sternebra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:32:20Z

[Term]
id: MP:0012283
name: decreased sternebra number
def: "reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced sternebra number" EXACT []
is_a: MP:0012282 ! abnormal sternebra number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:32:20Z

[Term]
id: MP:0012284
name: increased sternebra number
def: "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012282 ! abnormal sternebra number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:32:20Z

[Term]
id: MP:0012285
name: misaligned sternebrae
def: "abnormal alignment of the sternebrae along the ventral midline" [https://orcid.org/0000-0002-6490-7723]
synonym: "malaligned sternebrae" EXACT []
synonym: "malpositioned sternebrae" EXACT []
is_a: MP:0004322 ! abnormal sternebra morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T12:33:06Z

[Term]
id: MP:0012286
name: decreased frequency of paradoxical sleep
def: "decreased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased frequency of rapid eye movement sleep" EXACT []
synonym: "decreased frequency of REM sleep" EXACT []
is_a: MP:0003194 ! abnormal frequency of paradoxical sleep
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012287
name: increased frequency of paradoxical sleep
def: "increased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased frequency of rapid eye movement sleep" EXACT []
synonym: "increased frequency of REM sleep" EXACT []
is_a: MP:0003194 ! abnormal frequency of paradoxical sleep
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012288
name: abnormal paradoxical sleep pattern
def: "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal rapid eye movement sleep pattern" EXACT []
synonym: "abnormal REM sleep pattern" EXACT []
is_a: MP:0001501 ! abnormal sleep pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012289
name: abnormal non-rapid eye movement sleep pattern
def: "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [https://orcid.org/0000-0003-3691-0324]
comment: NREM sleep was divided into four stages in the Rechtschaffen and Kales (R&K) standardization of 1968. That has been reduced to three in the 2007 update by The American Academy of Sleep Medicine (AASM), combining the previous stage 3 and 4 to a single stage 3 also known as deep sleep or slow-wave sleep. The three stages that comprise NREM sleep account for 75-80 percent of total sleep time in humans.
synonym: "abnormal NREM sleep pattern" EXACT []
is_a: MP:0001501 ! abnormal sleep pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012290
name: abnormal slow-wave sleep pattern
def: "any anonaly in the third, or deep sleep stage of NREM sleep" [https://orcid.org/0000-0003-3691-0324]
comment: NREM sleep was divided into four stages in the Rechtschaffen and Kales (R&K) standardization of 1968. That has been reduced to three in the 2007 update by The American Academy of Sleep Medicine (AASM), combining the previous stage 3 and 4 to a single stage 3 also known as deep sleep or slow-wave sleep.
synonym: "abnormal deep sleep pattern" EXACT []
synonym: "abnormal SWS pattern" EXACT []
is_a: MP:0012289 ! abnormal non-rapid eye movement sleep pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012291
name: increased slow-wave sleep duration
def: "increased length of time of the third, or deep sleep stage of NREM sleep" [https://orcid.org/0000-0003-3691-0324]
comment: NREM sleep was divided into four stages in the Rechtschaffen and Kales (R&K) standardization of 1968. That has been reduced to three in the 2007 update by The American Academy of Sleep Medicine (AASM), combining the previous stage 3 and 4 to a single stage 3 also known as deep sleep or slow-wave sleep.
synonym: "increased deep sleep duration" EXACT []
synonym: "increased SWS duration" EXACT []
is_a: MP:0012290 ! abnormal slow-wave sleep pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012292
name: decreased slow-wave sleep duration
def: "reduced length of time of the third, or deep sleep stage of NREM sleep" [https://orcid.org/0000-0003-3691-0324]
comment: NREM sleep was divided into four stages in the Rechtschaffen and Kales (R&K) standardization of 1968. That has been reduced to three in the 2007 update by The American Academy of Sleep Medicine (AASM), combining the previous stage 3 and 4 to a single stage 3 also known as deep sleep or slow-wave sleep.
synonym: "decreased deep sleep duration" EXACT []
synonym: "decreased SWS duration" EXACT []
is_a: MP:0012290 ! abnormal slow-wave sleep pattern
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T13:01:55Z

[Term]
id: MP:0012293
name: impaired active avoidance behavior
def: "impaired ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002798 ! abnormal active avoidance behavior
is_a: MP:0012312 ! impaired avoidance learning behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T14:41:42Z

[Term]
id: MP:0012294
name: enhanced active avoidance behavior
def: "enhanced ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [https://orcid.org/0000-0003-3691-0324]
synonym: "enhanced active avoidance behaviour" EXACT []
is_a: MP:0002798 ! abnormal active avoidance behavior
is_a: MP:0012313 ! enhanced avoidance learning behavior
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T14:41:42Z

[Term]
id: MP:0012295
name: enhanced discrimination learning
def: "enhanced ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002802 ! abnormal discrimination learning
is_a: MP:0012314 ! enhanced learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T14:47:48Z

[Term]
id: MP:0012296
name: impaired discrimination learning
def: "impaired ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002802 ! abnormal discrimination learning
is_a: MP:0012315 ! impaired learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T14:47:48Z

[Term]
id: MP:0012297
name: hyperactivity elicited by feed restriction
def: "increased activity after restriction of food" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008911 ! induced hyperactivity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:03:37Z

[Term]
id: MP:0012298
name: hypoactivity in response to feed restriction
def: "decreased activity after restriction of food" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0031392 ! hypoactivity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:05:26Z

[Term]
id: MP:0012299
name: hydropic allantois
def: "excessive accumulation of fluid within the allantoic sac" [https://orcid.org/0000-0002-6490-7723]
synonym: "hydrallantois" EXACT []
synonym: "hydroponic allantois" EXACT []
synonym: "hydrops of allantois" EXACT []
is_a: MP:0001726 ! abnormal allantois morphology
is_a: MP:0001784 ! abnormal fluid regulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:09:48Z

[Term]
id: MP:0012300
name: abnormal umbilical cord blood vessel morphology
def: "any structural anomaly of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal umbilical blood vessel morphology" EXACT []
synonym: "abnormal umbilical vasculature" EXACT []
synonym: "abnormal umbilical vessel morphology" EXACT []
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:15:57Z

[Term]
id: MP:0012301
name: absent umbilical cord blood vessels
def: "absence of any of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent umbilical blood vessels" EXACT []
synonym: "absent umbilical vessels" EXACT []
is_a: MP:0012300 ! abnormal umbilical cord blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:17:07Z

[Term]
id: MP:0012302
name: umbilical artery stenosis
def: "abnormal narrowing or constriction of one or both umbilical arteries that carry deoxygenated, nutrient-depleted blood from the fetus to the placenta" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003230 ! abnormal umbilical artery morphology
is_a: MP:0006135 ! artery stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:18:48Z

[Term]
id: MP:0012303
name: umbilical vein stenosis
def: "abnormal narrowing or constriction of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010667 ! abnormal umbilical vein morphology
is_a: MP:0031477 ! vein stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:19:11Z

[Term]
id: MP:0012304
name: short umbilical cord
def: "decreased average umbilical cord length compared to normal" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased umbilical cord length" EXACT []
synonym: "reduced umbilical cord length" EXACT []
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:21:49Z

[Term]
id: MP:0012305
name: umbilical cord hemorrhage
def: "bleeding into or from the umbilical cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "umbilical cord bleeding" EXACT []
synonym: "umbilical cord haemorrhage" EXACT []
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-14T16:21:49Z

[Term]
id: MP:0012306
name: enhanced spatial learning
def: "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001463 ! abnormal spatial learning
is_a: MP:0012314 ! enhanced learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T09:41:57Z

[Term]
id: MP:0012307
name: impaired spatial learning
def: "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [https://orcid.org/0000-0003-3691-0324]
synonym: "spatial learning impairment in morris water maze test" NARROW []
synonym: "visible learning impairment in morris water maze test" NARROW []
is_a: MP:0001463 ! abnormal spatial learning
is_a: MP:0012315 ! impaired learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T09:43:19Z

[Term]
id: MP:0012308
name: salt preference
def: "subjects demonstrate predilection for salty tasting substances over other offered substances" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001432 ! abnormal food preference
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T12:42:27Z

[Term]
id: MP:0012309
name: abnormal ductus caroticus morphology
def: "any structural anomaly of the segment of dorsal aorta located between the third (III) and fourth (IV) aortic arches; it normally regresses early in development to allow the carotid axis to take its definitive appearance" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal carotid duct morphology" EXACT []
is_a: MP:0004787 ! abnormal dorsal aorta morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T15:25:58Z

[Term]
id: MP:0012310
name: persistent ductus caroticus
def: "uni- or bilateral persistence of the segment of dorsal aorta located between the third (III) and fourth (IV) aortic arches, which normally regresses early in development; persistence of ductus caroticus with regression of third arch or fourth arch causes the internal and external carotid arteries to arise from the aortic arch on the left side" [https://orcid.org/0000-0002-6490-7723]
synonym: "persistent carotid duct" EXACT []
is_a: MP:0010464 ! abnormal aortic arch and aortic arch branch attachment
is_a: MP:0012309 ! abnormal ductus caroticus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T15:25:58Z

[Term]
id: MP:0012311
name: decreased defecation amount
def: "decrease in the amount of discharge of feces from the body" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased defaecation amount" EXACT []
is_a: MP:0020147 ! abnormal defecation amount
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-15T15:36:25Z

[Term]
id: MP:0012312
name: impaired avoidance learning behavior
def: "impaired ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased avoidance learning behavior" EXACT []
synonym: "impaired avoidance learning behaviour" EXACT []
synonym: "reduced avoidance learning behavior" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior
is_a: MP:0012315 ! impaired learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:08:04Z

[Term]
id: MP:0012313
name: enhanced avoidance learning behavior
def: "enhanced ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [https://orcid.org/0000-0001-5208-3432]
synonym: "enhanced avoidance learning behaviour" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior
is_a: MP:0012314 ! enhanced learning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:08:04Z

[Term]
id: MP:0012314
name: enhanced learning
def: "enhanced ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
is_a: MP:0002063 ! abnormal learning/memory/conditioning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:12:17Z

[Term]
id: MP:0012315
name: impaired learning
def: "impaired ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
is_a: MP:0002063 ! abnormal learning/memory/conditioning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:12:17Z

[Term]
id: MP:0012316
name: enhanced conditioning behavior
def: "enhanced ability to change behavior in response to a reward or punishment each time an action is performed" [http://dictionary.reference.com/browse/conditioning]
synonym: "enhanced conditioning behaviour" EXACT []
synonym: "increased conditioning behavior" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:12:17Z

[Term]
id: MP:0012317
name: impaired conditioning behavior
def: "impaired ability to change behavior in response to a reward or punishment each time an action is performed" [http://dictionary.reference.com/browse/conditioning]
synonym: "decreased conditioning behavior" EXACT []
synonym: "impaired conditioning behaviour" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:12:17Z

[Term]
id: MP:0012318
name: slow extinction of fear memory
def: "impaired ability or inability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
is_a: MP:0003106 ! abnormal fear-related response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:47:45Z

[Term]
id: MP:0012319
name: fast extinction of fear memory
def: "enhanced ability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
is_a: MP:0003106 ! abnormal fear-related response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T13:49:33Z

[Term]
id: MP:0012320
name: abnormal body fat mass
def: "aberrant physical bulk or volume of fat in the whole body" [MPD:Molly]
is_a: MP:0000003 ! abnormal adipose tissue morphology
is_a: MP:0005451 ! abnormal body composition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:08:45Z

[Term]
id: MP:0012321
name: abnormal total tissue mass
def: "aberrant physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue" [MPD:Molly]
is_a: MP:0005451 ! abnormal body composition
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:08:45Z

[Term]
id: MP:0012322
name: decreased total tissue mass
def: "decreased physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue" [MPD:Molly]
is_a: MP:0012321 ! abnormal total tissue mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:08:45Z

[Term]
id: MP:0012323
name: increased total tissue mass
def: "increased physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue" [MPD:Molly]
is_a: MP:0012321 ! abnormal total tissue mass
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:08:45Z

[Term]
id: MP:0012324
name: abnormal circulating antithrombin level
def: "aberrant blood level of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation" [ISBN:0-683-40008-8, MPD:Molly]
comment: Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012325
name: decreased circulating antithrombin level
def: "lower than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation; low levels are associated with vein thrombosis and pulmonary embolism" [ISBN:0-683-40008-8, MPD:Molly]
synonym: "reduced circulating antithrombin level" EXACT []
is_a: MP:0012324 ! abnormal circulating antithrombin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012326
name: increased circulating antithrombin level
def: "higher than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation" [ISBN:0-683-40008-8, MPD:Molly]
is_a: MP:0012324 ! abnormal circulating antithrombin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012327
name: abnormal circulating factor VIII level
def: "aberrant levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]
synonym: "abnormal AHF level" EXACT []
synonym: "abnormal anti-hemophilic factor level" EXACT []
synonym: "abnormal Coagulation Factor VIII level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012328
name: decreased circulating factor VIII level
def: "reduced levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]
synonym: "decreased AHF level" BROAD []
synonym: "decreased anti-hemophilic factor level" BROAD []
synonym: "decreased Coagulation Factor VIII level" BROAD []
synonym: "reduced AHF level" BROAD []
synonym: "reduced anti-hemophilic factor level" BROAD []
synonym: "reduced circulating factor VIII level" EXACT []
synonym: "reduced Coagulation Factor VIII level" BROAD []
is_a: MP:0012327 ! abnormal circulating factor VIII level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012329
name: increased circulating factor VIII level
def: "greater levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]
synonym: "increased AHF level" EXACT []
synonym: "increased anti-hemophilic factor level" EXACT []
synonym: "increased Coagulation Factor VIII level" EXACT []
is_a: MP:0012327 ! abnormal circulating factor VIII level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012330
name: decreased circulating fibrinogen level
def: "reduced levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hypofibrinogenaemia" EXACT []
synonym: "hypofibrinogenemia" EXACT []
synonym: "reduced circulating fibrinogen level" EXACT []
is_a: MP:0010213 ! abnormal circulating fibrinogen level
is_a: MP:0014500 ! decreased acute phase protein level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012331
name: increased circulating fibrinogen level
def: "greater levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "hyperfibrinogenaemia" EXACT []
synonym: "hyperfibrinogenemia" EXACT []
is_a: MP:0010213 ! abnormal circulating fibrinogen level
is_a: MP:0014499 ! increased acute phase protein level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012332
name: decreased circulating fibronectin level
def: "reduced blood level of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development" [MPD:Molly]
synonym: "decreased plasma fibronectin level" NARROW []
synonym: "decreased soluble fibronectin level" BROAD []
synonym: "reduced circulating fibronectin level" EXACT []
synonym: "reduced plasma fibronectin level" NARROW []
synonym: "reduced soluble fibronectin level" BROAD []
is_a: MP:0011912 ! abnormal circulating fibronectin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012333
name: increased circulating fibronectin level
def: "greater blood level of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development" [MPD:Molly]
synonym: "increased plasma fibronectin level" NARROW []
synonym: "increased soluble fibronectin level" EXACT []
is_a: MP:0011912 ! abnormal circulating fibronectin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012334
name: decreased circulating homocysteine level
def: "reduced amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [https://orcid.org/0000-0003-3691-0324]
comment: A homocysteine measurement is the quantification of homocsyteine in blood or urine and is used in the diagnosis of B12 and/or folate deficiency, and as part of a cardiac risk assessment.
synonym: "decreased blood serum homocysteine level" EXACT []
synonym: "hypohomocysteinemia" EXACT []
synonym: "reduced blood serum homocysteine level" EXACT []
synonym: "reduced circulating homocysteine level" EXACT []
is_a: MP:0006076 ! abnormal circulating homocysteine level
is_a: MP:0014531 ! decreased circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012335
name: increased circulating homocysteine level
def: "greater amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [https://orcid.org/0000-0003-3691-0324]
comment: A homocysteine measurement is the quantification of homocsyteine in blood or urine and is used in the diagnosis of B12 and/or folate deficiency, and as part of a cardiac risk assessment.
synonym: "hyperhomocystinemia" EXACT []
synonym: "increased blood serum homocysteine level" EXACT []
is_a: MP:0006076 ! abnormal circulating homocysteine level
is_a: MP:0014530 ! increased circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012336
name: decreased vitamin D level
def: "reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
synonym: "decreased calciferol level" NARROW []
synonym: "decreased calciol level" NARROW []
synonym: "decreased cholecalciferol level" NARROW []
synonym: "decreased ergocalciferol level" NARROW []
synonym: "decreased vitamin D2 level" NARROW []
synonym: "decreased vitamin D3 level" NARROW []
is_a: MP:0011228 ! abnormal vitamin D level
is_a: MP:0012225 ! decreased sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012337
name: increased vitamin D level
def: "greater level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
synonym: "increased calciferol level" NARROW []
synonym: "increased calciol level" NARROW []
synonym: "increased cholecalciferol level" NARROW []
synonym: "increased ergocalciferol level" NARROW []
synonym: "increased vitamin D2 level" NARROW []
synonym: "increased vitamin D3 level" NARROW []
is_a: MP:0011228 ! abnormal vitamin D level
is_a: MP:0012226 ! increased sterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012338
name: decreased bile salt level
def: "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [https://orcid.org/0000-0003-3691-0324, MESH:D04.808.105]
synonym: "decreased bile acid level" RELATED []
synonym: "decreased bile amount" EXACT []
synonym: "decreased bile volume" NARROW []
is_a: MP:0004774 ! abnormal bile salt level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012339
name: hyperkalemia
def: "excessively high concentrations of potassium in the circulating blood; may be due to renal insufficiency or to mineralocorticoid deficiency or resistance" [ISBN:0-683-40008-8]
synonym: "hyperkalaemia" EXACT []
synonym: "hyperpotassaemia" EXACT []
synonym: "hyperpotassemia" EXACT []
is_a: MP:0005627 ! increased circulating potassium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-22T15:42:02Z

[Term]
id: MP:0012340
name: decreased testicular teratoma incidence
def: "less than the expected number of a usually benign tumor found in the testis that is the result of an anomaly of germ cell development, occurring in a specific population in a given time period; teratomas typically contains a diversity of tissues often representing all organ systems such as hair, teeth, bone, thyroid, or nerve tissue" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001146 ! abnormal testis morphology
is_a: MP:0012416 ! decreased gland tumor incidence
is_a: MP:0012417 ! decreased reproductive system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T10:45:03Z

[Term]
id: MP:0012341
name: low preference for an addictive substance
def: "reduced behavioral response induced by a foreign compound, such as low consumption preference, low induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002553 ! preference for addictive substance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T10:55:11Z

[Term]
id: MP:0012342
name: high preference for an addictive substance
def: "enhanced behavioral response induced by a foreign compound, such as high consumption preference, high induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002553 ! preference for addictive substance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T10:55:11Z

[Term]
id: MP:0012343
name: increased gnawing activity
def: "increased biting or chewing on something" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001388 ! abnormal stationary movement
is_a: MP:0003491 ! abnormal voluntary movement
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T11:16:03Z

[Term]
id: MP:0012344
name: decreased gnawing activity
def: "decreased biting or chewing on something" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001388 ! abnormal stationary movement
is_a: MP:0003491 ! abnormal voluntary movement
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T11:16:03Z

[Term]
id: MP:0012345
name: increased tail rattling
def: "increased movement of the tail in rapid succession" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001391 ! abnormal tail movements
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T11:16:03Z

[Term]
id: MP:0012346
name: decreased tail rattling
def: "decreased movement of the tail in rapid succession" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001391 ! abnormal tail movements
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T11:16:03Z

[Term]
id: MP:0012347
name: low sweet preference
def: "subjects demonstrate a low predilection for sweet tasting substances over other offered substances" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001432 ! abnormal food preference
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T12:55:41Z

[Term]
id: MP:0012348
name: decreased susceptibility to induction of seizure by inducing agent
def: "higher threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "resistant to induction of seizure by inducing agent" RELATED []
is_a: MP:0009357 ! abnormal seizure response to inducing agent
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T13:04:07Z

[Term]
id: MP:0012349
name: increased susceptibility to induction of seizure by inducing agent
def: "lower threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "susceptible to induction of seizure by inducing agent" RELATED []
is_a: MP:0009357 ! abnormal seizure response to inducing agent
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T13:04:07Z

[Term]
id: MP:0012350
name: increased aggression towards males in competition for females
def: "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward males when in competition for females" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001354 ! increased aggression towards male mice
is_a: MP:0002566 ! abnormal sexual interaction
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T13:25:07Z

[Term]
id: MP:0012351
name: cornea degeneration
def: "a retrogressive impairment of function or destruction of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "corneal degeneration" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T16:17:24Z

[Term]
id: MP:0012352
name: progressive cornea degeneration
def: "the state or process of the cornea deteriorating progressively over time" [https://orcid.org/0000-0001-5208-3432]
synonym: "progressive corneal degeneration" EXACT []
is_a: MP:0012351 ! cornea degeneration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T16:17:24Z

[Term]
id: MP:0012353
name: bilateral cornea degeneration
def: "the state or process of the cornea deteriorating in both eyes" [https://orcid.org/0000-0001-5208-3432]
synonym: "bilateral corneal degeneration" EXACT []
is_a: MP:0012351 ! cornea degeneration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-25T16:17:24Z

[Term]
id: MP:0012354
name: abnormal prothrombin time
def: "abnormal amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
is_a: MP:0002551 ! abnormal blood coagulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012355
name: decreased prothrombin time
def: "decreased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
synonym: "shortened prothrombin time" EXACT []
is_a: MP:0005607 ! decreased bleeding time
is_a: MP:0012354 ! abnormal prothrombin time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012356
name: increased prothrombin time
def: "increased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
synonym: "prolonged prothrombin time" EXACT []
is_a: MP:0005606 ! increased bleeding time
is_a: MP:0012354 ! abnormal prothrombin time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012357
name: abnormal partial thromboplastin time
def: "abnormal amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
synonym: "abnormal activated partial thromboplastin time" EXACT []
synonym: "abnormal activated thromboplastin time" EXACT []
synonym: "abnormal aPTT" EXACT []
is_a: MP:0002551 ! abnormal blood coagulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012358
name: decreased partial thromboplastin time
def: "decreased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
synonym: "decreased activated thromboplastin time" EXACT []
synonym: "decreased aPTT" EXACT []
synonym: "reduced aPPT" EXACT []
synonym: "reduced partial thromboplastin time" EXACT []
synonym: "shortened partial thromboplastin time" EXACT []
is_a: MP:0005607 ! decreased bleeding time
is_a: MP:0012357 ! abnormal partial thromboplastin time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012359
name: increased partial thromboplastin time
def: "increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
synonym: "increased activated thromboplastin time" EXACT []
synonym: "increased aPTT" EXACT []
synonym: "prolonged activated partial thromboplastin time" EXACT []
is_a: MP:0005606 ! increased bleeding time
is_a: MP:0012357 ! abnormal partial thromboplastin time
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012360
name: abnormal large unstained cell number
def: "aberrant number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493]
comment: Aberrations in the count of large unstained cells may be indicative of viral disease or leukemia.
synonym: "abnormal LUC number" EXACT []
is_a: MP:0000716 ! abnormal immune system cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012361
name: decreased large unstained cell number
def: "decreased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493]
comment: Aberrations in the count of large unstained cells may be indicative of viral disease or leukemia.
synonym: "decreased LUC number" EXACT []
is_a: MP:0005016 ! decreased lymphocyte cell number
is_a: MP:0012360 ! abnormal large unstained cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012362
name: increased large unstained cell number
def: "increased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493]
comment: Aberrations in the count of large unstained cells may be indicative of viral disease or leukemia.
synonym: "increased LUC number" EXACT []
is_a: MP:0005013 ! increased lymphocyte cell number
is_a: MP:0012360 ! abnormal large unstained cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012363
name: abnormal erythrocyte sodium level
def: "anomaly in the amount in red blood cells of sodium" [MPD:Molly]
is_a: MP:0001776 ! abnormal circulating sodium level
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012364
name: decreased erythrocyte sodium level
def: "decrease in the amount in red blood cells of sodium" [MPD:Molly]
is_a: MP:0005634 ! decreased circulating sodium level
is_a: MP:0012363 ! abnormal erythrocyte sodium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012365
name: increased erythrocyte sodium level
def: "increase in the amount in red blood cells of sodium" [MPD:Molly]
is_a: MP:0005633 ! increased circulating sodium level
is_a: MP:0012363 ! abnormal erythrocyte sodium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012366
name: abnormal erythrocyte magnesium level
def: "anomaly in the amount in red blood cells of magnesium" [MPD:Molly]
is_a: MP:0001771 ! abnormal circulating magnesium level
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012367
name: decreased erythrocyte magnesium level
def: "decrease in the amount in red blood cells of magnesium" [MPD:Molly]
is_a: MP:0010093 ! decreased circulating magnesium level
is_a: MP:0012366 ! abnormal erythrocyte magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012368
name: increased erythrocyte magnesium level
def: "increase in the amount in red blood cells of magnesium" [MPD:Molly]
is_a: MP:0010092 ! increased circulating magnesium level
is_a: MP:0012366 ! abnormal erythrocyte magnesium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012369
name: abnormal erythrocyte potassium level
def: "anomaly in the amount in red blood cells of potassium" [MPD:Molly]
is_a: MP:0002447 ! abnormal erythrocyte morphology
is_a: MP:0002668 ! abnormal circulating potassium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012370
name: decreased erythrocyte potassium level
def: "decrease in the amount in red blood cells of potassium" [MPD:Molly]
is_a: MP:0005628 ! decreased circulating potassium level
is_a: MP:0012369 ! abnormal erythrocyte potassium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012371
name: increased erythrocyte potassium level
def: "increase in the amount in red blood cells of potassium" [MPD:Molly]
is_a: MP:0005627 ! increased circulating potassium level
is_a: MP:0012369 ! abnormal erythrocyte potassium level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012372
name: abnormal erythrocyte ion content
def: "abnormal quantity in red blood cells of atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012373
name: abnormal erythrocyte magnesium ion content
def: "abnormal quantity in red blood cells of magnesium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012372 ! abnormal erythrocyte ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012374
name: decreased erythrocyte magnesium ion content
def: "decreased quantity in red blood cells of magnesium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012373 ! abnormal erythrocyte magnesium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012375
name: increased erythrocyte magnesium ion content
def: "increased quantity in red blood cells of magnesium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012373 ! abnormal erythrocyte magnesium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012376
name: abnormal erythrocyte potassium ion content
def: "abnormal quantity in red blood cells of potassium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012372 ! abnormal erythrocyte ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012377
name: decreased erythrocyte potassium ion content
def: "decreased quantity in red blood cells of potassium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012376 ! abnormal erythrocyte potassium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012378
name: increased erythrocyte potassium ion content
def: "increased quantity in red blood cells of potassium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012376 ! abnormal erythrocyte potassium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012379
name: abnormal erythrocyte sodium ion content
def: "abnormal quantity in red blood cells of sodium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012372 ! abnormal erythrocyte ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012380
name: decreased erythrocyte sodium ion content
def: "decreased quantity in red blood cells of sodium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012379 ! abnormal erythrocyte sodium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012381
name: increased erythrocyte sodium ion content
def: "increased quantity in red blood cells of sodium atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0012379 ! abnormal erythrocyte sodium ion content
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012382
name: abnormal blood cell physiology
def: "aberrant measurable or observable characteristic related to the function of or processes in any of the cells found in the blood" [MPD:Molly]
is_a: MP:0001545 ! abnormal hematopoietic system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012384
name: abnormal erythrocyte ion transport
def: "aberrant measurable or observable characteristic related to the movement in red blood cells of atoms carrying an electric charge" [MPD:Molly]
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0003656 ! abnormal erythrocyte physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012385
name: abnormal erythrocyte potassium:chloride symporter activity
def: "aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)" [GO:0015379, MPD:Molly]
is_a: MP:0012384 ! abnormal erythrocyte ion transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012386
name: decreased erythrocyte potassium:chloride symporter activity
def: "decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)" [MPD:Molly]
is_a: MP:0012385 ! abnormal erythrocyte potassium:chloride symporter activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012387
name: increased erythrocyte potassium:chloride symporter activity
def: "increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)" [MPD:Molly]
is_a: MP:0012385 ! abnormal erythrocyte potassium:chloride symporter activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012388
name: abnormal erythrocyte sodium:hydrogen antiporter activity
def: "aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)" [GO:0015385, MPD:Molly]
is_a: MP:0012384 ! abnormal erythrocyte ion transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012389
name: decreased erythrocyte sodium:hydrogen antiporter activity
def: "decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)" [MPD:Molly]
is_a: MP:0012388 ! abnormal erythrocyte sodium:hydrogen antiporter activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012390
name: increased erythrocyte sodium:hydrogen antiporter activity
def: "increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)" [MPD:Molly]
is_a: MP:0012388 ! abnormal erythrocyte sodium:hydrogen antiporter activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012391
name: abnormal erythrocyte sodium:potassium-exchanging ATPase activity
def: "aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)" [GO:0005391, MPD:Molly]
is_a: MP:0012384 ! abnormal erythrocyte ion transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012392
name: decreased erythrocyte sodium:potassium-exchanging ATPase activity
def: "decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)" [MPD:Molly]
is_a: MP:0012391 ! abnormal erythrocyte sodium:potassium-exchanging ATPase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012393
name: increased erythrocyte sodium:potassium-exchanging ATPase activity
def: "increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)" [MPD:Molly]
is_a: MP:0012391 ! abnormal erythrocyte sodium:potassium-exchanging ATPase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012394
name: abnormal erythrocyte calcium-activated potassium channel activity
def: "aberrant catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient" [GO:0015269, MPD:Molly]
is_a: MP:0012384 ! abnormal erythrocyte ion transport
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012395
name: decreased erythrocyte calcium-activated potassium channel activity
def: "decreased catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient" [MPD:Molly]
is_a: MP:0012394 ! abnormal erythrocyte calcium-activated potassium channel activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012396
name: increased erythrocyte calcium-activated potassium channel activity
def: "increased catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient" [MPD:Molly]
is_a: MP:0012394 ! abnormal erythrocyte calcium-activated potassium channel activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012397
name: abnormal nucleated erythrocyte cell number
def: "abnormal numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MPD:Molly]
is_a: MP:0002447 ! abnormal erythrocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012398
name: decreased nucleated erythrocyte cell number
def: "decreased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MPD:Molly]
is_a: MP:0012397 ! abnormal nucleated erythrocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-11-26T09:38:45Z

[Term]
id: MP:0012399
name: short nails
def: "decrease in the length of the nails" [https://orcid.org/0000-0003-4606-0597]
synonym: "brachyonychia" EXACT []
synonym: "decreased nail length" EXACT []
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T19:14:27Z

[Term]
id: MP:0012400
name: nail dystrophy
def: "the presence of misshapen or partially destroyed nail plates, fequently with keratin often accumulating between the dystrophic nail plate and nail bed; often due to trauma or infection" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T19:25:26Z

[Term]
id: MP:0012401
name: long nails
def: "increased length of the nails" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased nail length" EXACT []
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T19:25:50Z

[Term]
id: MP:0012402
name: abnormal nail bed morphology
def: "any structural anomaly of the dermis and epidermis directly below the nail plate" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T19:27:27Z

[Term]
id: MP:0012403
name: abnormal nail plate morphology
def: "any structural anomally of the hard and translucent portion of the nail, composed of keratin, which serves to protect the tips of digits" [GO:0035880, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T19:28:07Z

[Term]
id: MP:0012404
name: abnormal nail color
def: "a variation in an expected nail color, that may be due to infection, inflammation or other causes" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal nail colour" EXACT []
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T20:26:13Z

[Term]
id: MP:0012405
name: abnormal nail matrix morphology
def: "any structural anomaly of the nail-forming area of the nail bed comprised of a germinal matrix, responsible for most of the nail production, and the sterile matrix, a secondary site of nail production which is tightly adherent to the nail plate" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000579 ! abnormal nail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-02T20:32:05Z

[Term]
id: MP:0012406
name: increased stomach glandular epithelium tumor incidence
def: "greater than the expected number of tumors originating in the stomach glandular epithelium in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased stomach glandular epithelium tumour incidence" EXACT []
is_a: MP:0010301 ! increased stomach tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T11:27:19Z

[Term]
id: MP:0012407
name: increased gastric gastrinoma incidence
def: "higher than normal incidence of an epithelial tumor in the stomach that secretes an excess of gastrin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012406 ! increased stomach glandular epithelium tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T11:27:20Z

[Term]
id: MP:0012408
name: increased duodenum glandular epithelium tumor incidence
def: "greater than the expected number of tumors originating in the duodenal glandular epithelium in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased duodenum glandular epithelium tumour incidence" EXACT []
is_a: MP:0003271 ! abnormal duodenum morphology
is_a: MP:0010279 ! increased gastrointestinal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T11:27:20Z

[Term]
id: MP:0012409
name: increased duodenal gastrinoma incidence
def: "higher than normal incidence of an epithelial tumor in the duodenum that secretes an excess of gastrin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased duodenum gastrinoma incidence" EXACT []
is_a: MP:0012408 ! increased duodenum glandular epithelium tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T11:27:21Z

[Term]
id: MP:0012410
name: increased pancreatic gastrinoma incidence
def: "higher than normal incidence of a tumor in the pancreas that secretes an excess of gastrin, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0009153 ! increased pancreas tumor incidence
is_a: MP:0010279 ! increased gastrointestinal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T11:27:21Z

[Term]
id: MP:0012411
name: increased granulosa cell tumor incidence
def: "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased granulosa cell tumour incidence" EXACT []
is_a: MP:0008000 ! increased ovary tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T12:50:41Z

[Term]
id: MP:0012412
name: increased Type B reticulum cell tumor incidence
def: "greater than the expected number of neoplasms derived from reticulum cells in a given population in a given time period; type B neoplasms are tumors of mixed cellularity of reticulum cells, lymphocytes, plasma cells, eosinophils, and neutrophils" [PMID:13233863, PMID:4869134]
synonym: "increased Type B reticulum cell tumour incidence" EXACT []
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-03T14:33:28Z

[Term]
id: MP:0012413
name: decreased muscle tumor incidence
def: "less than the expected number of tumors originating in muscle tissue in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased muscle tumour incidence" EXACT []
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T10:59:28Z

[Term]
id: MP:0012414
name: decreased rhabdomyosarcoma incidence
def: "less than the expected number of a malignant tumor derived from skeletal (striated) muscle, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012413 ! decreased muscle tumor incidence
is_a: MP:0012415 ! decreased sarcoma incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:00:05Z

[Term]
id: MP:0012415
name: decreased sarcoma incidence
def: "less than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period" [DOID:1115]
is_a: MP:0010283 ! decreased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:00:49Z

[Term]
id: MP:0012416
name: decreased gland tumor incidence
def: "less than the expected number of tumors originating in a gland in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased gland tumour incidence" EXACT []
is_a: MP:0002163 ! abnormal gland morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012417
name: decreased reproductive system tumor incidence
def: "less than the expected number of tumors originating in the reproductive system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased reproductive system tumour incidence" EXACT []
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012418
name: decreased eye tumor incidence
def: "less than the expected number of tumors originating in the eye in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased eye tumour incidence" EXACT []
is_a: MP:0002092 ! abnormal eye morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012419
name: decreased cardiovascular system tumor incidence
def: "less than the expected number of tumors originating in the cardiovascular system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cardiovascular system tumour incidence" EXACT []
is_a: MP:0002127 ! abnormal cardiovascular system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012420
name: decreased hemolymphoid system tumor incidence
def: "less than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased haemolymphoid system tumour incidence" EXACT []
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012421
name: decreased hepatobiliary system tumor incidence
def: "less than the expected number of tumors originating in the hepatobiliary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased hepatobiliary system tumour incidence" EXACT []
is_a: MP:0002138 ! abnormal hepatobiliary system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012422
name: decreased integument system tumor incidence
def: "less than the expected number of tumors originating in the integument system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased integument system tumour incidence" EXACT []
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012423
name: decreased nervous system tumor incidence
def: "less than the expected number of tumors originating in the nervous system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased nervous system tumour incidence" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012424
name: decreased alimentary system tumor incidence
def: "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased alimentary system tumour incidence" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012425
name: decreased respiratory system tumor incidence
def: "less than the expected number of tumors originating in the respiratory system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased respiratory system tumour incidence" EXACT []
is_a: MP:0002132 ! abnormal respiratory system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012426
name: decreased skeletal tumor incidence
def: "less than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased skeletal tumour incidence" EXACT []
is_a: MP:0005508 ! abnormal skeleton morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012427
name: decreased urinary system tumor incidence
def: "less than the expected number of tumors originating in the urinary system in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased urinary system tumour incidence" EXACT []
is_a: MP:0000516 ! abnormal renal/urinary system morphology
is_a: MP:0010282 ! decreased organ/body region tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T11:44:46Z

[Term]
id: MP:0012428
name: decreased granulosa cell tumor incidence
def: "less than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased granulosa cell tumour incidence" EXACT []
is_a: MP:0012433 ! decreased ovarian tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T14:55:46Z

[Term]
id: MP:0012429
name: decreased myoepithelioma incidence
def: "less than the expected number of neoplasms of the cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells, in a given population in a given time period" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010283 ! decreased classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T15:22:14Z

[Term]
id: MP:0012430
name: decreased Type B reticulum cell tumor incidence
def: "less than the expected number of neoplasms derived from reticulum cells in a given population in a given time period; type B neoplasms are tumors of mixed cellularity of reticulum cells, lymphocytes, plasma cells, eosinophils, and neutrophils" [PMID:13233863, PMID:4869134]
synonym: "decreased Type B reticulum cell tumour incidence" EXACT []
is_a: MP:0012420 ! decreased hemolymphoid system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T15:23:18Z

[Term]
id: MP:0012431
name: increased lymphoma incidence
alt_id: MP:0002022
def: "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0003-3691-0324]
synonym: "increased lymphsarcoma incidence" EXACT []
synonym: "lymphoid tumor" RELATED []
synonym: "lymphoid tumour" RELATED []
is_a: MP:0010273 ! increased classified tumor incidence
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T15:36:28Z

[Term]
id: MP:0012432
name: decreased prostate gland tumor incidence
def: "less than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased prostate gland tumour incidence" EXACT []
synonym: "decreased prostatic tumor incidence" EXACT []
synonym: "decreased prostatic tumour incidence" EXACT []
is_a: MP:0001158 ! abnormal prostate gland morphology
is_a: MP:0012416 ! decreased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:38:44Z

[Term]
id: MP:0012433
name: decreased ovarian tumor incidence
def: "less than the expected number of neoplams in the ovary occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased ovarian tumour incidence" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology
is_a: MP:0012416 ! decreased gland tumor incidence
is_a: MP:0012417 ! decreased reproductive system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:40:16Z

[Term]
id: MP:0012434
name: decreased intestinal adenoma incidence
def: "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0012424 ! decreased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:43:49Z

[Term]
id: MP:0012435
name: decreased colon tumor incidence
def: "less than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased colon tumour incidence" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0012424 ! decreased alimentary system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:45:41Z

[Term]
id: MP:0012436
name: increased colon tumor incidence
def: "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased colon tumour incidence" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0010279 ! increased gastrointestinal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:46:31Z

[Term]
id: MP:0012437
name: increased Harderian gland tumor incidence
def: "greater than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased Harderian gland tumour incidence" EXACT []
is_a: MP:0005248 ! abnormal Harderian gland morphology
is_a: MP:0010288 ! increased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:51:17Z

[Term]
id: MP:0012438
name: decreased Harderian gland tumor incidence
def: "less than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased Harderian gland tumour incidence" EXACT []
is_a: MP:0005248 ! abnormal Harderian gland morphology
is_a: MP:0012416 ! decreased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T21:51:44Z

[Term]
id: MP:0012439
name: decreased pituitary gland tumor incidence
def: "less than the expected number of neoplams in the pituitary gland, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased pituitary gland tumour incidence" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology
is_a: MP:0012416 ! decreased gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:01:14Z

[Term]
id: MP:0012440
name: abnormal neutrophil cell number
def: "deviation in the count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes" [CL:0000775, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005065 ! abnormal neutrophil morphology
is_a: MP:0020201 ! abnormal granulocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:06:01Z

[Term]
id: MP:0012441
name: abnormal monocyte cell number
def: "any deviation in the count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0002620 ! abnormal monocyte morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:08:23Z

[Term]
id: MP:0012442
name: abnormal basophil cell number
def: "deviation of the count of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size" [CL:0000767, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002422 ! abnormal basophil morphology
is_a: MP:0020201 ! abnormal granulocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:12:35Z

[Term]
id: MP:0012443
name: increased corpus callosum size
def: "larger thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0020573 ! abnormal corpus callosum size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012444
name: thin hippocampus molecular cell layer
def: "decrease in the width of the cytoarchitectural region of the hippocampus consisting of a composite of the two outermost layers of the hippocampus, the Stratum lacunosum-moleculare and the Stratum radiatum" [UBERON_0005368]
subset: IMPC
subset: Sanger_Terms
synonym: "thin stratum moleculare" EXACT []
is_a: MP:0008286 ! abnormal hippocampus molecular cell layer
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012445
name: thin hippocampus stratum radiatum
def: "decrease in the width of the layer located immediately above the pyramidal cell layer in CA2 and CA1 and superficial to the stratum lucidum in CA3" [NIFSTD:birnlex_1298, UBERON_0005372]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011151 ! abnormal hippocampus stratum radiatum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012446
name: thin hippocampus stratum oriens
def: "decrease in the width of the layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3" [NIFSTD:birnlex_4113, UBERON_0005371]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0011150 ! abnormal hippocampus stratum oriens morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012447
name: thick cerebellar granule layer
def: "increased thickness of the innermost cortical layer of the cerebellum that contains granule cells" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "increased cerebellar granule layer width" EXACT []
synonym: "thick IGL" EXACT []
synonym: "thick internal granule layer" EXACT []
is_a: MP:0000886 ! abnormal cerebellar granule layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012448
name: abnormal primary motor cortex morphology
def: "any structural anomaly of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord; the primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain" [UBERON:0001384]
subset: IMPC
subset: Sanger_Terms
synonym: "motor cortex" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0000799 ! abnormal precentral gyrus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012449
name: increased primary motor cortex size
def: "greater size of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord" [https://orcid.org/0000-0003-3691-0324, UBERON:0001384]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged motor cortex" EXACT []
is_a: MP:0012448 ! abnormal primary motor cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012450
name: decreased primary motor cortex size
def: "reduced size of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord" [https://orcid.org/0000-0003-3691-0324, UBERON:0001384]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced motor cortex" RELATED []
synonym: "reduced primary motor cortex size" EXACT []
is_a: MP:0012448 ! abnormal primary motor cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012451
name: abnormal retrosplenial granular cortex morphology
def: "any structural anomaly of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation" [PMID:1308170]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0012489 ! abnormal retrosplenial region morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012452
name: increased retrosplenial granular cortex size
def: "greater size of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation" [https://orcid.org/0000-0003-3691-0324, PMID:1308170]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged retrosplenial granular cortex" EXACT []
is_a: MP:0012451 ! abnormal retrosplenial granular cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012453
name: decreased retrosplenial granular cortex size
def: "reduced size of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation" [https://orcid.org/0000-0003-3691-0324, PMID:1308170]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced retrosplenial granular cortex" RELATED []
synonym: "reduced retrosplenial granular cortex size" EXACT []
is_a: MP:0012451 ! abnormal retrosplenial granular cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012454
name: abnormal mammillothalamic tract morphology
def: "any structural anomaly of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal mammillo-thalamic tract morphology" EXACT []
synonym: "abnormal mammillothalamic axonal tract morphology" EXACT []
synonym: "abnormal mammillothalamic fasciculus morphology" EXACT []
synonym: "abnormal Vicq d'Azyr bundle morphology" EXACT []
is_a: MP:0000778 ! abnormal nervous system tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012455
name: increased mammillothalamic tract size
def: "greater size of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged mammillothalamic axonal tract" EXACT []
synonym: "enlarged mammillothalamic tract" RELATED []
synonym: "increased  Vicq d'Azyr bundle size" EXACT []
synonym: "increased mammillothalamic fasciculus size" EXACT []
is_a: MP:0012454 ! abnormal mammillothalamic tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012456
name: decreased mammillothalamic tract size
def: "reduced size of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased  Vicq d'Azyr bundle size" EXACT []
synonym: "decreased mammillothalamic fasciculus size" EXACT []
synonym: "reduced mammillothalamic axonal tract size" EXACT []
synonym: "reduced mammillothalamic tract" EXACT []
synonym: "reduced mammillothalamic tract size" EXACT []
is_a: MP:0012454 ! abnormal mammillothalamic tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012457
name: increased hippocampus pyramidal cell length
def: "increased length of a multipolar projection neuron in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012458
name: decreased hippocampus pyramidal cell length
def: "reduced length of a multipolar projection neuron in the hippocampus pyramidal cell layer" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced hippocampus pyramidal cell length" EXACT []
is_a: MP:0009940 ! abnormal hippocampus pyramidal cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012459
name: increased dentate gyrus size
def: "greater size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged dentate gyrus" EXACT []
is_a: MP:0000812 ! abnormal dentate gyrus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012460
name: decreased dentate gyrus size
def: "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced dentate gyrus" EXACT []
synonym: "reduced dentate gyrus size" EXACT []
is_a: MP:0000812 ! abnormal dentate gyrus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012461
name: increased brain internal capsule size
def: "greater size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged brain internal capsule" EXACT []
synonym: "enlarged internal capsule of telencephalon" EXACT []
is_a: MP:0008128 ! abnormal brain internal capsule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012462
name: decreased brain internal capsule size
def: "reduced size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced brain internal capsule" EXACT []
synonym: "reduced brain internal capsule size" RELATED []
synonym: "reduced internal capsule of telencephalon" EXACT []
is_a: MP:0008128 ! abnormal brain internal capsule morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012463
name: increased optic tract size
def: "greater size of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged optic tract" EXACT []
is_a: MP:0004267 ! abnormal optic tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012464
name: decreased optic tract size
def: "reduced size of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region" [ISBN:0-683-40008-8]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced optic tract" EXACT []
synonym: "reduced optic tract size" EXACT []
is_a: MP:0004267 ! abnormal optic tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012465
name: increased hippocampal fimbria size
def: "greater size of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged hippocampal fimbria" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012466
name: decreased hippocampal fimbria size
def: "reduced size of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced hippocampal fimbria" EXACT []
synonym: "reduced hippocampal fimbria size" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012467
name: increased striatum size
def: "greater size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
subset: IMPC
subset: Sanger_Terms
synonym: "increased striate body size" EXACT []
is_a: MP:0004077 ! abnormal striatum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012468
name: decreased striatum size
def: "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [https://orcid.org/0000-0003-3691-0324, ISBN:0838580343]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced striate body size" EXACT []
is_a: MP:0004077 ! abnormal striatum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012469
name: increased genu of the facial nerve size
def: "greater size of the bend in the facial nerve at the lateral end of the internal acoustic meatus" [https://orcid.org/0000-0003-3691-0324, UBERON:0014915]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged genu of the facial nerve size" EXACT []
is_a: MP:0001071 ! abnormal facial nerve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012470
name: decreased genu of the facial nerve size
def: "reduced size of the bend in the facial nerve at the lateral end of the internal acoustic meatus" [https://orcid.org/0000-0003-3691-0324, UBERON:0014915]
subset: IMPC
subset: Sanger_Terms
synonym: "reduced genu of the facial nerve size" EXACT []
is_a: MP:0001071 ! abnormal facial nerve morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012471
name: increased cerebellum interpositus nucleus size
def: "greater size of the nucelus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable" [ISBN:0-683-40008-8]
synonym: "enlarged cerebellum interpositus nucleus" EXACT []
synonym: "enlarged cerebellum interpositus nucleus size" EXACT []
is_a: MP:0009984 ! abnormal cerebellum interpositus nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012472
name: decreased cerebellum interpositus nucleus size
def: "reduced size of the nucelus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable" [ISBN:0-683-40008-8]
synonym: "reduced cerebellum interpositus nucleus" EXACT []
synonym: "reduced cerebellum interpositus nucleus size" EXACT []
synonym: "small cerebellum interpositus nucleus" EXACT []
is_a: MP:0009984 ! abnormal cerebellum interpositus nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012473
name: increased cingulate cortex size
def: "greater size of the thick belt of cortex encircling the corpus callosum that responsible for producing emotional responses to physical sensations of pain and for cognitive control" [https://orcid.org/0000-0003-3691-0324, PMID:21331082]
synonym: "enlarged cingulate cortex" RELATED []
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012474
name: decreased cingulate cortex size
def: "reduced size of the thick belt of cortex encircling the corpus callosum that responsible for producing emotional responses to physical sensations of pain and for cognitive control" [https://orcid.org/0000-0003-3691-0324, PMID:21331082]
synonym: "reduced cingulate cortex" RELATED []
synonym: "reduced cingulate cortex size" EXACT []
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012475
name: increased piriform cortex size
def: "increased size of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract" [PMID:17714095]
synonym: "enlarged piriform cortex" EXACT []
is_a: MP:0010009 ! abnormal piriform cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012476
name: decreased piriform cortex size
def: "reduced size of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract" [PMID:17714095]
synonym: "reduced piriform cortex" EXACT []
synonym: "reduced piriform cortex size" EXACT []
is_a: MP:0010009 ! abnormal piriform cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012477
name: increased secondary somatosensory cortex size
def: "greater size of the area of the upper bank of the lateral sulcus that is involved in somatic sensation" [ISBN:0838580343]
synonym: "enlarged secondary somatosensory cortex" EXACT []
synonym: "enlarged secondary somatosensory cortex size" EXACT []
is_a: MP:0000863 ! abnormal secondary somatosensory cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012478
name: decreased secondary somatosensory cortex size
def: "reduced size of the area of the upper bank of the lateral sulcus that is involved in somatic sensation" [ISBN:0838580343]
synonym: "reduced secondary somatosensory cortex" EXACT []
synonym: "reduced secondary somatosensory cortex size" EXACT []
is_a: MP:0000863 ! abnormal secondary somatosensory cortex morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012479
name: increased amygdala size
def: "greater size of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [ISBN:0-683-40008-8]
synonym: "increased amygdaloid area size" EXACT []
synonym: "increased amygdaloid body size" EXACT []
synonym: "increased amygdaloid complex size" EXACT []
synonym: "increased amygdaloid nucleus" RELATED []
synonym: "increased amygdaloid nucleus size" EXACT []
is_a: MP:0000818 ! abnormal amygdala morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012480
name: decreased amygdala size
def: "reduced size of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [ISBN:0-683-40008-8]
synonym: "decreased amygdaloid area size" EXACT []
synonym: "decreased amygdaloid body size" EXACT []
synonym: "decreased amygdaloid complex size" EXACT []
synonym: "decreased amygdaloid nucleus" RELATED []
synonym: "decreased amygdaloid nucleus size" EXACT []
synonym: "reduced amygdaloid area size" EXACT []
synonym: "reduced amygdaloid body size" EXACT []
synonym: "reduced amygdaloid complex size" EXACT []
synonym: "reduced amygdaloid nucleus size" EXACT []
is_a: MP:0000818 ! abnormal amygdala morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012481
name: increased habenula size
def: "greater size of the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [https://orcid.org/0000-0003-3691-0324]
synonym: "enlarged habenular nucleus" EXACT []
is_a: MP:0004082 ! abnormal habenula morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012482
name: decreased habenula size
def: "reduced size of the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased habenular nucleus size" EXACT []
synonym: "reduced habenular nucleus" EXACT []
synonym: "reduced habenular nucleus size" EXACT []
is_a: MP:0004082 ! abnormal habenula morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012483
name: increased corticospinal tract size
def: "greater size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
synonym: "enlarged corticospinal tract" EXACT []
is_a: MP:0002878 ! abnormal corticospinal tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012484
name: decreased corticospinal tract size
def: "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
synonym: "reduced corticospinal tract" EXACT []
synonym: "reduced corticospinal tract size" EXACT []
is_a: MP:0002878 ! abnormal corticospinal tract morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012485
name: increased cochlear VIII nucleus size
def: "greater size of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "enlarged cochlear nucleus size" EXACT []
synonym: "increased cochlear nucleus size" EXACT []
is_a: MP:0012490 ! abnormal cochlear VIII nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012486
name: decreased cochlear VIII nucleus size
def: "reduced size of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "decreased cochlear nucleus size" EXACT []
synonym: "reduced cochlear nucleus size" EXACT []
synonym: "reduced cochlear VIII nucleus size" EXACT []
synonym: "small cochlear VIII nucleus" EXACT []
is_a: MP:0012490 ! abnormal cochlear VIII nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012487
name: increased cerebellum dentate nucleus size
def: "greater size of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8]
synonym: "enlarged cerebellum dentate nucleus" EXACT []
synonym: "increased cerebellum lateral nucleus size" EXACT []
synonym: "increased corpus dentatum size" EXACT []
synonym: "increased dentate cerebellar nucleus size" EXACT []
synonym: "increased lateral cerebellar nucleus size" EXACT []
is_a: MP:0009980 ! abnormal cerebellum dentate nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012488
name: decreased cerebellum dentate nucleus size
def: "reduced size of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers" [ISBN:0-683-40008-8]
synonym: "decreased cerebellum lateral nucleus size" EXACT []
synonym: "decreased corpus dentatum size" EXACT []
synonym: "decreased dentate cerebellar nucleus size" EXACT []
synonym: "decreased lateral cerebellar nucleus size" EXACT []
synonym: "reduced cerebellum dentate nucleus" EXACT []
synonym: "reduced cerebellum dentate nucleus size" EXACT []
synonym: "small cerebellum dentate nucleus" EXACT []
is_a: MP:0009980 ! abnormal cerebellum dentate nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-04T22:39:39Z

[Term]
id: MP:0012489
name: abnormal retrosplenial region morphology
def: "any structural anomaly of one of the key brain regions required for cognitive functions, including episodic memory, navigation, imagination and planning for the future; the retrosplenial region can be divided into three parts, the retrosplenial granular cortex A, the retrosplenial granular cortex B and the retrosplenial dysgranular cortex; each subdivision of the retrosplenial cortex projects to a discrete terminal field in the hippocampal formation" [PMID:1308170, PMID:19812579]
synonym: "abnormal retrosplenial cortex morphology" RELATED []
synonym: "abnormal RSC morphology" RELATED []
is_a: MP:0004167 ! abnormal cingulate gyrus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-08T16:26:18Z

[Term]
id: MP:0012490
name: abnormal cochlear VIII nucleus morphology
alt_id: MP:0006333
def: "any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
subset: Sanger_Terms
synonym: "abnormal cochlear nuclei morphology" RELATED []
synonym: "abnormal cochlear nucleus morphology" EXACT []
is_a: MP:0000848 ! abnormal pons morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T13:34:35Z

[Term]
id: MP:0012491
name: larynx stenosis
def: "abnormal narrowing or constriction of the organ of voice production located between the pharynx and the trachea" [https://orcid.org/0000-0002-6490-7723]
synonym: "laryngeal stenosis" EXACT []
synonym: "narrow larynx" EXACT []
is_a: MP:0002249 ! abnormal larynx morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T15:50:52Z

[Term]
id: MP:0012492
name: pharyngeal arch artery hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pharyngeal arch artery, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic arches hypoplasia" EXACT []
synonym: "branchial arch artery hypoplasia" EXACT []
synonym: "embryonic aortic arch artery hypoplasia" RELATED []
synonym: "PAA hypoplasia" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T15:55:23Z

[Term]
id: MP:0012493
name: absent pharyngeal arch arteries
def: "absence of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent aortic arches" EXACT []
synonym: "absent branchial arch arteries" EXACT []
synonym: "absent branchial arch artery" EXACT []
synonym: "absent embryonic aortic arch artery" RELATED []
synonym: "absent PAA" EXACT []
synonym: "absent pharyngeal arch artery" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T15:55:23Z

[Term]
id: MP:0012494
name: dilated pharyngeal arch artery
def: "stretched or widened aperture of the luminal space of one or more of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic arch dilation" EXACT []
synonym: "branchial arch artery dilation" EXACT []
synonym: "dilated aortic arch" EXACT []
synonym: "dilated aortic arches" EXACT []
synonym: "dilated branchial arch arteries" EXACT []
synonym: "dilated branchial arch artery" EXACT []
synonym: "dilated embryonic aortic arch arteries" RELATED []
synonym: "dilated embryonic aortic arch artery" RELATED []
synonym: "dilated PAA" EXACT []
synonym: "dilated PAAs" EXACT []
synonym: "dilated pharyngeal arch arteries" EXACT []
synonym: "PAA dilation" EXACT []
synonym: "pharyngeal arch artery dilation" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0004938 ! dilated vasculature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T15:55:23Z

[Term]
id: MP:0012495
name: pharyngeal arch artery stenosis
def: "diffuse constriction or narrowing of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic arches stenosis" EXACT []
synonym: "branchial arch artery stenosis" EXACT []
synonym: "embryonic aortic arch artery stenosis" RELATED []
synonym: "PAA stenosis" EXACT []
is_a: MP:0002672 ! abnormal pharyngeal arch artery morphology
is_a: MP:0006135 ! artery stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-09T15:55:23Z

[Term]
id: MP:0012496
name: abnormal pleuropericardial membrane morphology
def: "any structural anomaly of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity" [https://orcid.org/0000-0003-3691-0324, UBERON:0006278]
synonym: "abnormal pleuropericardial folds morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T11:47:00Z

[Term]
id: MP:0012497
name: absent pleuropericardial membrane
def: "absence of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity" [https://orcid.org/0000-0003-3691-0324, UBERON:0006278]
synonym: "absent pleuropericardial folds" EXACT []
is_a: MP:0012496 ! abnormal pleuropericardial membrane morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T11:47:16Z

[Term]
id: MP:0012498
name: abnormal cardiogenic plate morphology
def: "any structural anomaly of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002925 ! abnormal cardiovascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T13:33:24Z

[Term]
id: MP:0012499
name: absent cardiogenic plate
def: "absence of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; normally, angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012498 ! abnormal cardiogenic plate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T13:33:24Z

[Term]
id: MP:0012500
name: abnormal angioblastic cord morphology
def: "any structural anomaly of the cordlike masses of splanchnic mesenchymal cells ventral to the primordial pericardial coelom that arrange themselves side by side to form the primordia of the endocardial heart tubes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal angiogenic cell cluster morphology" EXACT []
is_a: MP:0002925 ! abnormal cardiovascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T13:33:24Z

[Term]
id: MP:0012501
name: abnormal pericardial cavity morphology
def: "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cavitas pericardiaca morphology" EXACT []
synonym: "abnormal cavity of pericardial sac" EXACT []
synonym: "abnormal pericardial celom morphology" EXACT []
synonym: "abnormal pericardial coelom morphology" EXACT []
synonym: "abnormal pericardial space morphology" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2013-12-10T13:33:24Z

[Term]
id: MP:0012502
name: decreased hindbrain apoptosis
def: "decrease in the number of cells of the hindbrain undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased rhombencephalon apoptosis" EXACT []
synonym: "reduced hindbrain apoptosis" EXACT []
synonym: "reduced rhombencephalon apoptosis" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0006043 ! decreased apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012503
name: increased midbrain apoptosis
def: "increase in the number of cells of the midbrain undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased mesencephalon apoptosis" EXACT []
is_a: MP:0014178 ! increased brain apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012504
name: increased forebrain apoptosis
def: "increase in the number of cells of the forebrain undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased prosencephalon apoptosis" EXACT []
is_a: MP:0014178 ! increased brain apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012505
name: increased neural tube apoptosis
def: "increase in the number of cells of the neural tube undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0006042 ! increased apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012506
name: brain atrophy
def: "acquired diminution of the size of the brain associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic brain" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012507
name: midbrain atrophy
def: "acquired diminution of the size of the midbrain associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic mesencephalon" EXACT []
synonym: "atrophic midbrain" EXACT []
synonym: "mesencephalon atrophy" EXACT []
is_a: MP:0000897 ! abnormal midbrain morphology
is_a: MP:0012506 ! brain atrophy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012508
name: forebrain atrophy
def: "acquired diminution of the size of the forebrain associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic forebrain" EXACT []
synonym: "atrophic prosencephalon" EXACT []
synonym: "prosencephalon atrophy" EXACT []
is_a: MP:0000783 ! abnormal forebrain morphology
is_a: MP:0012506 ! brain atrophy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T11:30:46Z

[Term]
id: MP:0012509
name: neural tube degeneration
def: "a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002151 ! abnormal neural tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T13:17:46Z

[Term]
id: MP:0012510
name: abnormal aortic sac morphology
def: "any structural abnormality of the dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002925 ! abnormal cardiovascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T13:21:06Z

[Term]
id: MP:0012511
name: dilated aortic sac
def: "abnormally stretched or widened aperture of the luminal space of the endothelial lined dilation that is located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic sac dilation" EXACT []
synonym: "dilated aortic sacs" EXACT []
is_a: MP:0004938 ! dilated vasculature
is_a: MP:0012510 ! abnormal aortic sac morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T13:22:33Z

[Term]
id: MP:0012512
name: abnormal sternum body morphology
def: "any structural anomaly of the middle and longest portion of the sternum, lying between the manubrium superiorly and the xiphoid process inferiorly; the body of the sternum (gladiolus), is considerably lengthier, narrower, and thinner than the manubrium, attaining its greatest breadth close to the lower end" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal body of sternum" EXACT []
synonym: "abnormal corpus sterni morphology" EXACT []
synonym: "abnormal gladiolus morphology" EXACT []
synonym: "abnormal mesosternum morphology" EXACT []
synonym: "abnormal midsternum morphology" EXACT []
synonym: "abnormal sternal body morphology" EXACT []
is_a: MP:0000157 ! abnormal sternum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T13:38:31Z

[Term]
id: MP:0012513
name: absent sternum body
def: "absence of the middle and longest portion of the sternum, lying between the manubrium superiorly and the xiphoid process inferiorly; the body of the sternum (gladiolus) is considerably lengthier, narrower, and thinner than the manubrium, attaining its greatest breadth close to the lower end" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent corpus sterni" EXACT []
synonym: "absent gladiolus" EXACT []
synonym: "absent mesosternum" EXACT []
synonym: "absent midsternum" EXACT []
synonym: "absent sternal body" EXACT []
is_a: MP:0012512 ! abnormal sternum body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T13:40:06Z

[Term]
id: MP:0012514
name: pectus excavatum
def: "a caved-in or sunken appearance of the anterior chest wall; the congenital deformity can either be present at birth or may not be visible until puberty" [https://orcid.org/0000-0002-6490-7723]
synonym: "cobbler's chest" EXACT []
synonym: "funnel chest" EXACT []
synonym: "pectus excavatus" EXACT []
synonym: "sunken chest" EXACT []
is_a: MP:0004134 ! abnormal chest morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T15:01:24Z

[Term]
id: MP:0012515
name: abnormal heart apex morphology
def: "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal apex cordis morphology" EXACT []
synonym: "abnormal cardiac apex morphology" EXACT []
is_a: MP:0000266 ! abnormal heart morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T15:33:11Z

[Term]
id: MP:0012516
name: absent metencephalon
def: "absence of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain normally composed of the cerebellum and the pons Varolii" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent anterior hindbrain" EXACT []
synonym: "absent anterior rhombencephalon" EXACT []
synonym: "absent epencephalon" EXACT []
synonym: "absent rostral hindbrain" EXACT []
synonym: "absent rostral rhombencephalon" EXACT []
is_a: MP:0000847 ! abnormal metencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T15:53:01Z

[Term]
id: MP:0012517
name: absent diencephalon
def: "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent betweenbrain" EXACT []
synonym: "absent interbrain" EXACT []
synonym: "absent thalamencephalon" EXACT []
is_a: MP:0000830 ! abnormal diencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T15:56:20Z

[Term]
id: MP:0012518
name: abnormal Brunner's gland morphology
def: "any structural anomaly of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal duodenal gland morphology" EXACT []
synonym: "abnormal gland of Brunner morphology" EXACT []
synonym: "abnormal glandula duodenales Brunneri morphology" EXACT []
synonym: "abnormal glandula duodenales morphology" EXACT []
is_a: MP:0000496 ! abnormal small intestine morphology
is_a: MP:0000511 ! abnormal intestinal mucosa morphology
is_a: MP:0014033 ! abnormal submucosal gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T16:43:17Z

[Term]
id: MP:0012519
name: dilated Brunner's gland
def: "stretched or widened aperture of the luminal space of one or more of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes" [https://orcid.org/0000-0002-6490-7723]
synonym: "Brunner's gland dilation" EXACT []
synonym: "dilated Brunner's glands" EXACT []
synonym: "dilated duodenal gland" EXACT []
synonym: "dilated duodenal glands" EXACT []
synonym: "dilated gland of Brunner" EXACT []
synonym: "dilated glands of Brunner" EXACT []
synonym: "dilated glandula duodenales" EXACT []
synonym: "dilated glandula duodenales Brunneri" EXACT []
synonym: "duodenal gland dilation" EXACT []
is_a: MP:0012518 ! abnormal Brunner's gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T16:58:33Z

[Term]
id: MP:0012520
name: absent Brunner's glands
def: "absence of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent duodenal glands" EXACT []
synonym: "absent glands of Brunner" EXACT []
synonym: "absent glandula duodenales" EXACT []
synonym: "absent glandula duodenales Brunneri" EXACT []
is_a: MP:0012518 ! abnormal Brunner's gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T16:58:33Z

[Term]
id: MP:0012521
name: abnormal buccopharyngeal membrane morphology
def: "any structural anomaly of the thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal oral membrane morphology" EXACT []
synonym: "abnormal oral plate morphology" EXACT []
synonym: "abnormal oropharyngeal membrane morphology" EXACT []
synonym: "abnormal pharyngeal membrane morphology" BROAD []
synonym: "abnormal pharyngeal septum morphology" EXACT []
is_a: MP:0003119 ! abnormal digestive system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T17:21:59Z

[Term]
id: MP:0012522
name: abnormal stomodeum morphology
def: "any structural anomaly of the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" [https://orcid.org/0000-0002-6490-7723, UBERON:0000930]
synonym: "abnormal mouth primordium" EXACT []
synonym: "abnormal primitive mouth morphology" EXACT []
synonym: "abnormal primitive oral cavity morphology" EXACT []
synonym: "abnormal stomatodaeum morphology" EXACT []
synonym: "abnormal stomatodeum morphology" EXACT []
synonym: "abnormal stomodaeum morphology" EXACT []
is_a: MP:0003119 ! abnormal digestive system development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T17:40:29Z

[Term]
id: MP:0012523
name: abnormal upper lip morphology
def: "any structural anomaly of the muscular fold forming the superior border of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal labium superius oris morphology" EXACT []
synonym: "abnormal upper jaw lip morphology" EXACT []
is_a: MP:0003769 ! abnormal lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:16:00Z

[Term]
id: MP:0012524
name: abnormal lower lip morphology
def: "any structural anomaly of the muscular fold bounding the opening of the mouth inferiorly" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal labium inferius oris morphology" EXACT []
synonym: "abnormal lower jaw lip morphology" EXACT []
is_a: MP:0003769 ! abnormal lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:16:00Z

[Term]
id: MP:0012525
name: abnormal rhombic lip morphology
def: "any structural anomaly of the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000913 ! abnormal brain development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:30:26Z

[Term]
id: MP:0012526
name: abnormal upper rhombic lip morphology
def: "any structural anomaly of the anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cerebellar anlage morphology" EXACT []
synonym: "abnormal presumptive cerebellum morphology" EXACT []
synonym: "abnormal rostral rhombic lip morphology" EXACT []
is_a: MP:0012525 ! abnormal rhombic lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:31:19Z

[Term]
id: MP:0012527
name: abnormal lower rhombic lip morphology
def: "any structural anomaly of the posterior portion of the rhombic lip contained within rhombomeres 2-8 which gives rise to several brainstem nuclei and the choroid plexus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal caudal rhombic lip morphology" EXACT []
is_a: MP:0012525 ! abnormal rhombic lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:31:19Z

[Term]
id: MP:0012528
name: abnormal zone of polarizing activity morphology
def: "any structural anomaly of the subset of cells found in the posterior mesenchyme region of the vertebrate limb bud; Sonic hedgehog (Shh) produced by ZPA represents the key mediator of the polarizing activity that regulates patterning of the limb along the anterio-posterior (A-P) axis" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ZPA morphology" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:40:59Z

[Term]
id: MP:0012529
name: abnormal decidua basalis morphology
def: "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal basal decidua morphology" EXACT []
synonym: "abnormal decidua placentalis morphology" EXACT []
synonym: "abnormal decidua serotina morphology" EXACT []
is_a: MP:0004256 ! abnormal maternal decidual layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:51:21Z

[Term]
id: MP:0012530
name: abnormal decidua capsularis morphology
def: "any structural anomaly of the layer of uterine endometrium overlying the implanted chorionic vesicle and facing the uterine cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal capsular decidua morphology" EXACT []
synonym: "abnormal decidua reflexa morphology" EXACT []
synonym: "abnormal membrana adventitia morphology" EXACT []
is_a: MP:0004256 ! abnormal maternal decidual layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T18:57:37Z

[Term]
id: MP:0012531
name: delayed limb development
def: "late onset of the induction and/or differentiation of the limbs" [https://orcid.org/0000-0002-6490-7723]
synonym: "retarded limb development" EXACT []
is_a: MP:0006279 ! abnormal limb development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T21:38:31Z

[Term]
id: MP:0012532
name: abnormal surface ectoderm morphology
def: "any structural anomaly of the surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm; cells from the surface ectoderm differentiate to form the epidermis; epithelia lining the mouth and nasal cavities; hair follicles and nails; the lacrimal, tarsal, salivary, sebaceous, sweat, and mammary glands, and anterior pituitary gland (adenohypophysis); inner and outer ear structures; the lens, and conjunctival and corneal epithelia; dental enamel; and the apical ectodermal ridge inducing development of the limb buds" [https://orcid.org/0000-0002-6490-7723, UBERON:0000076]
synonym: "abnormal external ectoderm morphology" EXACT []
is_a: MP:0014139 ! abnormal ectoderm morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T21:44:00Z

[Term]
id: MP:0012533
name: uveal coloboma
def: "congenital defect of the uvea in which some part of the structure is absent" [https://orcid.org/0000-0002-6490-7723]
synonym: "coloboma of the uvea" EXACT []
synonym: "uvea coloboma" EXACT []
is_a: MP:0005197 ! abnormal uvea morphology
is_a: MP:0005262 ! coloboma
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T21:50:18Z

[Term]
id: MP:0012534
name: abnormal optic fissure morphology
def: "any structural anomaly of the ventral groove formed by invagination of the optic cup and its stalk by vascular mesenchyme from which the hyaloid vessels develop; a transient gap in the ventral margin of the developing optic cup that eventually closes to complete the eye wall inferiorly and enclose the hyaloid vessels in a canal in the optic stalk" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal choroid fissure morphology" EXACT []
synonym: "abnormal choroidal fissure morphology" EXACT []
synonym: "abnormal embryonic fissure morphology" EXACT []
synonym: "abnormal fetal fissure morphology" EXACT []
synonym: "abnormal foetal fissure morphology" EXACT []
synonym: "abnormal retinal fissure morphology" EXACT []
is_a: MP:0001286 ! abnormal eye development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T22:09:42Z

[Term]
id: MP:0012535
name: abnormal optic fissure closure
def: "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal choroid fissure closure" EXACT []
synonym: "abnormal choroidal fissure closure" EXACT []
synonym: "abnormal embryonic fissure closure" EXACT []
synonym: "abnormal fetal fissure closure" EXACT []
synonym: "abnormal foetal fissure closure" EXACT []
synonym: "abnormal retinal fissure closure" EXACT []
synonym: "optic fissure closure defects" EXACT []
synonym: "persistent optic fissure" EXACT []
is_a: MP:0001286 ! abnormal eye development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T22:13:04Z

[Term]
id: MP:0012536
name: delayed optic fissure closure
def: "late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed choroid fissure closure" EXACT []
synonym: "delayed choroidal fissure closure" EXACT []
synonym: "delayed embryonic fissure closure" EXACT []
synonym: "delayed fetal fissure closure" EXACT []
synonym: "delayed foetal fissure closure" EXACT []
synonym: "delayed retinal fissure closure" EXACT []
is_a: MP:0012535 ! abnormal optic fissure closure
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-01T22:14:46Z

[Term]
id: MP:0012537
name: abnormal hyaloid artery morphology
def: "any structural anomaly of the artery which arises from the dorsal ophthalmic artery and enters the eye cup through the optic (choroid) fissure; the hyaloid artery is contained within the optic stalk of the eye, extends from the optic disc through the vitreous humor to the lens, and serves to supply nutrients to the developing lens in the growing fetus; it usually regresses (around 2 weeks after birth in mice and before birth in humans), with its proximal portion remaining as the central artery of the retina; regression of the hyaloid artery leaves a clear central zone through the vitreous humor, called the hyaloid canal or Cloquet's canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal arteria hyaloidea morphology" EXACT []
is_a: MP:0001286 ! abnormal eye development
is_a: MP:0031346 ! abnormal eye vasculature morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T11:32:58Z

[Term]
id: MP:0012538
name: persistent hyaloid artery
def: "incomplete regression of the hyaloid artery, usually accompanied by persistence of the hyperplastic primary vitreous; small remnants of the artery may remain with free remnants sometimes seen as floating material (aka muscae volitantes); an anterior remnant of the hyaloid artery can be seen as Mittendorf's dot, a small pinpoint-like scar on the posterior surface of the lens; a posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister's papilla" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyaloid artery remnant" EXACT []
synonym: "persistence of hyaloid artery" EXACT []
synonym: "persistent arteria hyaloidea" EXACT []
is_a: MP:0012537 ! abnormal hyaloid artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T11:32:58Z

[Term]
id: MP:0012539
name: Bergmeister's papilla
def: "a posterior remnant of the fetal hyaloid artery that arises from the center of the optic disc and consists of a small tuft of fibrous tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "epipapillary veil" EXACT []
is_a: MP:0012538 ! persistent hyaloid artery
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T11:32:58Z

[Term]
id: MP:0012540
name: abnormal lamina terminalis morphology
def: "any structural anomaly of the anterior-most (rostral) portion of the wall of the neural tube, formed by closure of the anterior neuropore; the median strip of the anterior wall of the prosencephalon, which persists in a relatively unchanged state as the cerebral hemispheres grow out forward beyond the original anterior end of the prosencephalon; in the developed brain, the lamina terminalis remains as the thin rostral wall of the third ventricle, stretching from the bases of the major cerebral commissures (the anterior commissure, the commissure of the fornix, and the rostrum of the corpus callosum) to the dorsal surface of the optic chiasm" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lamina cinerea morphology" EXACT []
synonym: "abnormal lamina terminalis of cerebrum morphology" EXACT []
synonym: "abnormal terminal plate morphology" EXACT []
synonym: "abnormal velum terminale morphology" EXACT []
is_a: MP:0002151 ! abnormal neural tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T12:40:51Z

[Term]
id: MP:0012541
name: absent lamina terminalis
def: "absence of the anterior-most (rostral) portion of the wall of the neural tube, formed by closure of the anterior neuropore; agenesis of the lamina terminalis results in anencephaly" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lamina cinerea" EXACT []
synonym: "absent lamina terminalis of cerebrum" EXACT []
synonym: "absent terminal plate" EXACT []
synonym: "absent velum terminale" EXACT []
synonym: "agenesis of lamina terminalis" EXACT []
is_a: MP:0012540 ! abnormal lamina terminalis morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T12:43:46Z

[Term]
id: MP:0012542
name: abnormal neuropore morphology
def: "any structural anomaly of either the anterior or posterior temporary opening leading from the central canal of the embryonic neural tube to the exterior; the anterior and posterior neuropores connect the lumen of the neural tube with the amniotic cavity" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002151 ! abnormal neural tube morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:20:22Z

[Term]
id: MP:0012543
name: abnormal rostral neuropore morphology
def: "any structural anomaly of the temporary opening at the extreme rostral (cephalic) end of the early embryonic prosencephalon (forebrain); the anterior neuropore appears before the process of neural tube closure is complete" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal anterior neuropore morphology" EXACT []
synonym: "abnormal cephalic neuropore morphology" EXACT []
synonym: "abnormal cranial neuropore morphology" EXACT []
is_a: MP:0012542 ! abnormal neuropore morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:21:16Z

[Term]
id: MP:0012544
name: abnormal caudal neuropore morphology
def: "any structural anomaly of the temporary opening at the extreme caudal end of the neural tube in early embryos; the posterior neuropore appears before the process of neural tube closure is complete" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal posterior neuropore morphology" EXACT []
is_a: MP:0012542 ! abnormal neuropore morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:21:16Z

[Term]
id: MP:0012545
name: syringomyelia
def: "a condition whereby a fluid-filled cyst or cavity (syrinx) develops within the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "myelosyringosis" EXACT []
synonym: "spinal cord cyst" EXACT []
synonym: "spinal cord cysts" EXACT []
synonym: "spinal cord syrinx" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:28:25Z

[Term]
id: MP:0012546
name: triangular face
def: "a face whose lower half becomes relatively thin, approaching an appearance of a triangle with a tip facing downwards; usually associated with a prominent forehead and micrognathia" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030071 ! abnormal face shape
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:32:03Z

[Term]
id: MP:0012547
name: spina bifida cystica
def: "spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection" [https://orcid.org/0000-0002-6490-7723]
synonym: "spina bifida aperta" EXACT []
synonym: "spina bifida manifesta" EXACT []
is_a: MP:0003054 ! spina bifida
is_a: MP:0031310 ! abnormal cyst
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:40:20Z

[Term]
id: MP:0012548
name: myelocele
def: "hernial protrusion of the spinal cord through an opening or defect in the vertebral column" [https://orcid.org/0000-0002-6490-7723]
synonym: "myelocoele" EXACT []
is_a: MP:0000929 ! open neural tube
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T13:45:01Z

[Term]
id: MP:0012549
name: hypoxemia
def: "subnormal arterial oxygen tension; deficient oxygenation of arterial blood" [ISBN:978-0-387-75246-4]
synonym: "decreased blood partial O2 level" EXACT []
synonym: "hypoxaemia" EXACT []
is_a: MP:0001574 ! abnormal oxygen level
is_a: MP:0002329 ! abnormal blood gas level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T14:30:49Z

[Term]
id: MP:0012550
name: respiratory acidosis
def: "acidosis caused by retention of and increased blood concentration of carbon dioxide, often caused by decreased ventilation (hypoventilation); results in decreased blood pH unless kidneys compensate by retaining bicarbonate" [ISBN:0-683-40008-8]
synonym: "carbon dioxide acidosis" EXACT []
synonym: "hypercapnic acidosis" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0003031 ! acidosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T15:27:49Z

[Term]
id: MP:0012551
name: metabolic acidosis
def: "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
is_a: MP:0003031 ! acidosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T15:28:08Z

[Term]
id: MP:0012552
name: lactic acidosis
def: "a form of acidosis in which an accumulation of lactic acid in tissues occurs; causes include tissue hypoxia and drug effects" [ISBN:0-683-40008-8]
is_a: MP:0012551 ! metabolic acidosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-02T15:31:32Z

[Term]
id: MP:0012553
name: decreased serum complement activity
def: "decreased ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes" [https://orcid.org/0000-0001-5208-3432]
synonym: "reduced serum complement activity" EXACT []
is_a: MP:0002471 ! abnormal complement pathway
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T15:57:18Z

[Term]
id: MP:0012554
name: increased serum complement activity
def: "increased ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002471 ! abnormal complement pathway
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T15:58:26Z

[Term]
id: MP:0012555
name: decreased cell death
def: "decreased occurrence of the cessation of function at the cellular level" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased cell viability" EXACT []
synonym: "reduced cell death" EXACT []
is_a: MP:0000313 ! abnormal cell death
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:01:30Z

[Term]
id: MP:0012556
name: increased cell death
def: "increased occurrence of the cessation of function at the cellular level" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased cell viability" EXACT []
is_a: MP:0000313 ! abnormal cell death
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:01:30Z

[Term]
id: MP:0012557
name: decreased calcium uptake by cardiac muscle
def: "decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease" [https://orcid.org/0000-0001-5208-3432, PMID:22902320]
is_a: MP:0004215 ! abnormal myocardial fiber physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:18:21Z

[Term]
id: MP:0012558
name: increased calcium uptake by cardiac muscle
def: "increased directed movement of calcium ions into the cardiac muscle; increased mitochondrial calcium ion uptake can trigger programmed necrosis in cardiac muscle" [https://orcid.org/0000-0001-5208-3432, PMID:22902320]
is_a: MP:0004215 ! abnormal myocardial fiber physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:18:54Z

[Term]
id: MP:0012559
name: decreased forebrain volume
def: "decrease from the average range of forebrain volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
synonym: "reduced forebrain volume" EXACT []
is_a: MP:0012138 ! decreased forebrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:38:19Z

[Term]
id: MP:0012560
name: increased forebrain volume
def: "increase from the average range of forebrain volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012139 ! increased forebrain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T16:39:11Z

[Term]
id: MP:0012561
name: decreased foot pad temperature
def: "decreased degree of heat natural to the foot pad-environment interface of a living being" [https://orcid.org/0000-0001-5208-3432]
synonym: "reduced foot pad temperature" EXACT []
is_a: MP:0005534 ! decreased body temperature
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T17:14:40Z

[Term]
id: MP:0012562
name: blood vessel degeneration
def: "a retrogressive impairment of function or destruction of the network of tubes that carries blood through the body" [https://orcid.org/0000-0001-5208-3432]
synonym: "blood vasculature degeneration" RELATED []
synonym: "vascular degeneration" RELATED []
is_a: MP:0001614 ! abnormal blood vessel morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T17:18:50Z

[Term]
id: MP:0012563
name: increased tumor incidence following infection
def: "greater than the expected number of neoplasms in a specific population after infection with a pathogen in a given time period, usually of a specific type" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002021 ! increased incidence of induced tumors
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T17:25:23Z

[Term]
id: MP:0012564
name: decreased tumor incidence following infection
def: "less than the expected number of neoplasms in a specific population after infection with a pathogen in a given time period, usually of a specific type" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased tumour incidence following infection" EXACT []
synonym: "reduced tumor incidence following infection" EXACT []
synonym: "reduced tumour incidence following infection" EXACT []
is_a: MP:0002053 ! decreased incidence of induced tumors
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T17:26:13Z

[Term]
id: MP:0012565
name: perivasculitis
def: "inflammation of a perivascular sheath surrounding a blood or lymph vessel, and the surrounding tissue" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001846 ! increased inflammatory response
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T17:39:02Z

[Term]
id: MP:0012566
name: decreased susceptibility to experimental autoimmune orchitis
def: "greater likelihood that an organism will develop disease characterized by lymphocytes surrounding the tubuli recti, spermatogenic disturbance and irreversible damage to the seminiferous epithelium" [PMID:23224596]
synonym: "reduced susceptibility to experimental autoimmune orchitis" EXACT []
is_a: MP:0005351 ! decreased susceptibility to autoimmune disorder
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:02:03Z

[Term]
id: MP:0012567
name: increased susceptibility to experimental autoimmune orchitis
def: "reduced likelihood that an organism will develop disease characterized by lymphocytes surrounding the tubuli recti, spermatogenic disturbance and irreversible damage to the seminiferous epithelium" [PMID:23224596]
is_a: MP:0005350 ! increased susceptibility to autoimmune disorder
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:03:58Z

[Term]
id: MP:0012568
name: decreased mammary gland tumor incidence in breeding females
def: "less than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased mammary gland tumour incidence in breeding females" EXACT []
synonym: "reduced mammary gland tumor incidence in breeding females" EXACT []
synonym: "reduced mammary gland tumour incidence in breeding females" EXACT []
is_a: MP:0010269 ! decreased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:44:03Z

[Term]
id: MP:0012569
name: decreased mammary gland tumor incidence in virgin females
def: "less than the expected number of neoplams in the mammary gland in female organisms that have never had sexual intercourse" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased mammary gland tumour incidence in virgin females" EXACT []
synonym: "reduced mammary gland tumor incidence in virgin females" EXACT []
synonym: "reduced mammary gland tumour incidence in virgin females" EXACT []
is_a: MP:0010269 ! decreased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:44:03Z

[Term]
id: MP:0012570
name: increased mammary gland tumor incidence in breeding females
def: "greater than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased mammary gland tumour incidence in breeding females" EXACT []
is_a: MP:0010299 ! increased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:57:36Z

[Term]
id: MP:0012571
name: increased mammary gland tumor incidence in virgin females
def: "greater than the expected number of neoplams in the mammary gland in female organisms that have never had sexual intercourse" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased mammary gland tumour incidence in virgin females" EXACT []
is_a: MP:0010299 ! increased mammary gland tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T18:57:36Z

[Term]
id: MP:0012572
name: increased susceptibility to chemically induced skin inflammation
def: "decreased dosage threshold or greater inflammatory response of the skin after topical application of chemical irritants" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0004947 ! skin inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T19:38:37Z

[Term]
id: MP:0012573
name: decreased susceptibility to chemically induced skin inflammation
def: "increased dosage threshold, or reduced or no inflammation of the skin after topical application of chemical irritants" [https://orcid.org/0000-0001-5208-3432]
synonym: "reduced susceptility to chemically induced skin inflammation" EXACT []
synonym: "resistance to chemically induced skin inflammation" EXACT []
is_a: MP:0004947 ! skin inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T19:38:37Z

[Term]
id: MP:0012574
name: decreased noradrenaline level
def: "reduced amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [https://orcid.org/0000-0001-5208-3432, ISBN:0198506732]
synonym: "decreased norepinephrine level" EXACT []
synonym: "reduced noradrenaline level" EXACT []
synonym: "reduced norepinephrine level" EXACT []
is_a: MP:0003964 ! abnormal noradrenaline level
is_a: MP:0014455 ! decreased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T20:10:51Z

[Term]
id: MP:0012575
name: increased noradrenaline level
def: "greater than normal amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [https://orcid.org/0000-0001-5208-3432, ISBN:0198506732]
synonym: "increased norepinephrine level" EXACT []
is_a: MP:0003964 ! abnormal noradrenaline level
is_a: MP:0014454 ! increased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T20:10:51Z

[Term]
id: MP:0012576
name: abnormal kidney glutathione peroxidase activity
def: "anomaly in the ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue" [GO:0004602, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal kidney GSH peroxidase activity" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology
is_a: MP:0011601 ! abnormal glutathione peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T20:48:11Z

[Term]
id: MP:0012577
name: decreased kidney glutathione peroxidase activity
def: "reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue" [GO:0004602, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased kidney GSH peroxidase activity" EXACT []
synonym: "reduced kidney glutathione peroxidase activity" EXACT []
synonym: "reduced kidney GSH peroxidase activity" EXACT []
is_a: MP:0011603 ! decreased glutathione peroxidase activity
is_a: MP:0012576 ! abnormal kidney glutathione peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T20:49:45Z

[Term]
id: MP:0012578
name: increased kidney glutathione peroxidase activity
def: "increased ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue" [GO:0004602, https://orcid.org/0000-0001-5208-3432]
synonym: "increased kidney GSH peroxidase activity" EXACT []
is_a: MP:0011602 ! increased glutathione peroxidase activity
is_a: MP:0012576 ! abnormal kidney glutathione peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T20:49:45Z

[Term]
id: MP:0012579
name: abnormal peroxidase activity
def: "anomaly in the ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O" [GO:0004601, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T21:00:17Z

[Term]
id: MP:0012580
name: decreased peroxidase activity
def: "reduced ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O" [GO:0004601, https://orcid.org/0000-0001-5208-3432]
synonym: "reduced peroxidase activity" EXACT []
is_a: MP:0012579 ! abnormal peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T21:00:17Z

[Term]
id: MP:0012581
name: decreased eosinophil peroxidase activity
def: "reduced ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O in eosinophils" [GO:0004601, https://orcid.org/0000-0001-5208-3432]
synonym: "reduced eosinophil peroxidase activity" EXACT []
is_a: MP:0012580 ! decreased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T21:00:17Z

[Term]
id: MP:0012582
name: increased peroxidase activity
def: "increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O" [GO:0004601, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012579 ! abnormal peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T21:00:17Z

[Term]
id: MP:0012583
name: increased eosinophil peroxidase activity
def: "increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O in eosinophils" [GO:0004601, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012582 ! increased peroxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-03T21:00:17Z

[Term]
id: MP:0012584
name: abnormal catechol O-methyltransferase activity
def: "anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol" [GO:0016206, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal catechol methyltransferase activity" EXACT []
synonym: "abnormal catecholamine O-methyltransferase activity" EXACT []
synonym: "abnormal COMT I activity" EXACT []
synonym: "abnormal COMT II activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:21:59Z

[Term]
id: MP:0012585
name: decreased catechol O-methyltransferase activity
def: "reduction in the ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol" [GO:0016206, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased catechol methyltransferase activity" EXACT []
synonym: "decreased catecholamine O-methyltransferase activity" EXACT []
synonym: "decreased COMT I activity" EXACT []
synonym: "decreased COMT II activity" EXACT []
synonym: "reduced catechol methyltransferase activity" EXACT []
synonym: "reduced catecholamine O-methyltransferase activity" EXACT []
synonym: "reduced COMT I activity" EXACT []
synonym: "reduced COMT II activity" EXACT []
is_a: MP:0012584 ! abnormal catechol O-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:21:59Z

[Term]
id: MP:0012586
name: increased catechol O-methyltransferase activity
def: "greater ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol" [GO:0016206, https://orcid.org/0000-0001-5208-3432]
synonym: "increased catechol methyltransferase activity" EXACT []
synonym: "increased catecholamine O-methyltransferase activity" EXACT []
synonym: "increased COMT I activity" EXACT []
synonym: "increased COMT II activity" EXACT []
is_a: MP:0012584 ! abnormal catechol O-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:21:59Z

[Term]
id: MP:0012587
name: decreased brain catechol O-methyltransferase activity
def: "reduced ability of brain tissue to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol" [GO:0016206, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased brain catechol methyltransferase activity" EXACT []
synonym: "decreased brain catecholamine O-methyltransferase activity" EXACT []
synonym: "decreased brain COMT I activity" EXACT []
synonym: "decreased brain COMT II activity" EXACT []
synonym: "reduced brain catechol methyltransferase activity" EXACT []
synonym: "reduced brain catecholamine O-methyltransferase activity" EXACT []
synonym: "reduced brain COMT I activity" EXACT []
synonym: "reduced brain COMT II activity" EXACT []
is_a: MP:0012585 ! decreased catechol O-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:21:59Z

[Term]
id: MP:0012588
name: increased brain catechol O-methyltransferase activity
def: "greater ability of brain tissue to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol" [GO:0016206, https://orcid.org/0000-0001-5208-3432]
synonym: "increased brain catechol methyltransferase activity" EXACT []
synonym: "increased brain catecholamine O-methyltransferase activity" EXACT []
synonym: "increased brain COMT I activity" EXACT []
synonym: "increased brain COMT II activity" EXACT []
is_a: MP:0012586 ! increased catechol O-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:21:59Z

[Term]
id: MP:0012589
name: abnormal choline O-acetyltransferase activity
def: "anomaly in the ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "abnormal CHOACTase activity" EXACT []
synonym: "abnormal choline acetylase activity" EXACT []
synonym: "abnormal choline acetyltransferase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:24:54Z

[Term]
id: MP:0012590
name: decreased choline O-acetyltransferase activity
def: "reduction in the ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "decreased CHOACTase activity" EXACT []
synonym: "decreased choline acetylase activity" EXACT []
synonym: "decreased choline acetyltransferase activity" EXACT []
synonym: "reduced acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "reduced CHOACTase activity" EXACT []
synonym: "reduced choline acetylase activity" EXACT []
is_a: MP:0012589 ! abnormal choline O-acetyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:24:54Z

[Term]
id: MP:0012591
name: increased choline O-acetyltransferase activity
def: "greater ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, https://orcid.org/0000-0001-5208-3432]
synonym: "increased acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "increased CHOACTase activity" EXACT []
synonym: "increased choline acetylase activity" EXACT []
synonym: "increased choline acetyltransferase activity" EXACT []
is_a: MP:0012589 ! abnormal choline O-acetyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:24:54Z

[Term]
id: MP:0012592
name: decreased brain choline acetyltransferase activity
def: "reduced ability of the brain to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased brain acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "decreased brain CHOACTase activity" EXACT []
synonym: "decreased brain choline acetylase activity" EXACT []
synonym: "reduced brain acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "reduced brain CHOACTase activity" EXACT []
synonym: "reduced brain choline acetylase activity" EXACT []
is_a: MP:0012590 ! decreased choline O-acetyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:24:54Z

[Term]
id: MP:0012593
name: increased brain choline acetyltransferase activity
def: "greater ability of the brain to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, https://orcid.org/0000-0001-5208-3432]
synonym: "increased brain acetyl-CoA:choline O-acetyltransferase activity" EXACT []
synonym: "increased brain CHOACTase activity" EXACT []
synonym: "increased brain choline acetylase activity" EXACT []
is_a: MP:0012591 ! increased choline O-acetyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:24:54Z

[Term]
id: MP:0012594
name: abnormal glutamate decarboxylase activity
def: "anomaly in the ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2" [GO:0004351, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal aspartic alpha-decarboxylase activity" EXACT []
synonym: "abnormal cysteic acid decarboxylase activity" EXACT []
synonym: "abnormal gamma-glutamate decarboxylase activity" EXACT []
synonym: "abnormal L-aspartate-alpha-decarboxylase activity" EXACT []
synonym: "abnormal L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) activity" EXACT []
synonym: "abnormal L-glutamate 1-carboxy-lyase activity" EXACT []
synonym: "abnormal L-glutamate alpha-decarboxylase activity" EXACT []
synonym: "abnormal L-glutamic acid decarboxylase activity" EXACT []
synonym: "abnormal L-glutamic decarboxylase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012595
name: decreased glutamate decarboxylase activity
def: "reduction in the ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2" [GO:0004351, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased aspartic alpha-decarboxylase activity" EXACT []
synonym: "decreased cysteic acid decarboxylase activity" EXACT []
synonym: "decreased gamma-glutamate decarboxylase activity" EXACT []
synonym: "decreased L-aspartate-alpha-decarboxylase activity" EXACT []
synonym: "decreased L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) activity" EXACT []
synonym: "decreased L-glutamate 1-carboxy-lyase activity" EXACT []
synonym: "decreased L-glutamate alpha-decarboxylase activity" EXACT []
synonym: "decreased L-glutamic acid decarboxylase activity" EXACT []
synonym: "decreased L-glutamic decarboxylase activity" EXACT []
synonym: "reduced aspartic alpha-decarboxylase activity" EXACT []
synonym: "reduced cysteic acid decarboxylase activity" EXACT []
synonym: "reduced gamma-glutamate decarboxylase activity" EXACT []
synonym: "reduced L-aspartate-alpha-decarboxylase activity" EXACT []
synonym: "reduced L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) activity" EXACT []
synonym: "reduced L-glutamate 1-carboxy-lyase activity" EXACT []
synonym: "reduced L-glutamate alpha-decarboxylase activity" EXACT []
synonym: "reduced L-glutamic acid decarboxylase activity" EXACT []
synonym: "reduced L-glutamic decarboxylase activity" EXACT []
is_a: MP:0012594 ! abnormal glutamate decarboxylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012596
name: increased glutamate decarboxylase activity
def: "greater ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2" [GO:0004351, https://orcid.org/0000-0001-5208-3432]
synonym: "increased aspartic alpha-decarboxylase activity" EXACT []
synonym: "increased cysteic acid decarboxylase activity" EXACT []
synonym: "increased gamma-glutamate decarboxylase activity" EXACT []
synonym: "increased L-aspartate-alpha-decarboxylase activity" EXACT []
synonym: "increased L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) activity" EXACT []
synonym: "increased L-glutamate 1-carboxy-lyase activity" EXACT []
synonym: "increased L-glutamate alpha-decarboxylase activity" EXACT []
synonym: "increased L-glutamic acid decarboxylase activity" EXACT []
synonym: "increased L-glutamic decarboxylase activity" EXACT []
is_a: MP:0012594 ! abnormal glutamate decarboxylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012597
name: abnormal nicotinamide N-methyltransferase activity
def: "anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine" [GO:0008112, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal nicotinamide methyltransferase activity" EXACT []
synonym: "abnormal S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012598
name: decreased nicotinamide N-methyltransferase activity
def: "reduction in the ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine" [GO:0008112, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased nicotinamide methyltransferase activity" EXACT []
synonym: "decreased S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT []
synonym: "reduced nicotinamide methyltransferase activity" EXACT []
synonym: "reduced S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT []
is_a: MP:0012597 ! abnormal nicotinamide N-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012599
name: increased nicotinamide N-methyltransferase activity
def: "greater ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine" [GO:0008112, https://orcid.org/0000-0001-5208-3432]
synonym: "increased nicotinamide methyltransferase activity" EXACT []
synonym: "increased S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT []
is_a: MP:0012597 ! abnormal nicotinamide N-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T06:33:49Z

[Term]
id: MP:0012600
name: abnormal alpha-fetoprotein level
def: "any anomaly in the amount of alpha fetoprotein protein" [PMID:7545495]
synonym: "abnormal alpha-foetoprotein level" EXACT []
is_a: MP:0008469 ! abnormal protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:22Z

[Term]
id: MP:0012601
name: decreased alpha-fetoprotein level
def: "less than the expected amount of alpha fetoprotein protein" [PMID:7545495]
synonym: "decreased alpha-foetoprotein level" EXACT []
synonym: "reduced alpha-fetoprotein level" EXACT []
is_a: MP:0012600 ! abnormal alpha-fetoprotein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:22Z

[Term]
id: MP:0012602
name: increased alpha-fetoprotein level
def: "more than the expected amount of alpha fetoprotein protein" [PMID:7545495]
synonym: "elevated alpha-fetoprotein level" EXACT []
synonym: "increased alpha-foetoprotein level" EXACT []
is_a: MP:0012600 ! abnormal alpha-fetoprotein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:22Z

[Term]
id: MP:0012603
name: abnormal glutathione level
def: "anomaly in the amount of a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856]
synonym: "abnormal GSH level" EXACT []
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:51Z

[Term]
id: MP:0012604
name: decreased glutathione level
def: "reduction in the amount of a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856]
synonym: "decreased GSH level" EXACT []
synonym: "reduced glutathione level" EXACT []
synonym: "reduced GSH level" EXACT []
is_a: MP:0012603 ! abnormal glutathione level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:51Z

[Term]
id: MP:0012605
name: decreased kidney glutathione level
def: "reduction in the amount of a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine in the kidney" [CHEBI:16856]
synonym: "decreased kidney GSH level" EXACT []
synonym: "reduced kidney glutathione level" EXACT []
synonym: "reduced kidney GSH level" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0012604 ! decreased glutathione level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:51Z

[Term]
id: MP:0012606
name: increased glutathione level
def: "increase in the amount of a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856]
synonym: "increased GSH level" EXACT []
is_a: MP:0012603 ! abnormal glutathione level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:51Z

[Term]
id: MP:0012607
name: increased kidney glutathione level
def: "increase in the amount of a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine in the kidney" [CHEBI:16856]
synonym: "increased kidney GSH level" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0012606 ! increased glutathione level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:10:51Z

[Term]
id: MP:0012608
name: abnormal complement C5 level
def: "any anomaly in the amount of complement C5 which is cleaved into 2 fragments, mediates inflammatory processes and forms part of the membrane attack complex" [MESH:D12.776.124.486.274.450]
synonym: "abnormal HC level" EXACT []
is_a: MP:0011566 ! abnormal complement protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:11:47Z

[Term]
id: MP:0012609
name: decreased complement C5 level
def: "decrease in the amount of complement C5" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced HC level" EXACT []
is_a: MP:0012608 ! abnormal complement C5 level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:11:47Z

[Term]
id: MP:0012610
name: increased complement C5 level
def: "increase in the amount of complement C5" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated HC level" EXACT []
is_a: MP:0012608 ! abnormal complement C5 level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T08:11:47Z

[Term]
id: MP:0012611
name: abnormal ceruloplasmin level
def: "any anomaly in the amount of ceruloplasmin, a ferroxidase enzyme that contains copper atoms in its structure" [https://en.wikipedia.org/wiki/Ceruloplasmin]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:19:55Z

[Term]
id: MP:0012612
name: decreased ceruloplasmin level
def: "decrease in the amount of ceruloplasmin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012611 ! abnormal ceruloplasmin level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:19:55Z

[Term]
id: MP:0012613
name: increased ceruloplasmin level
def: "increase in the amount of ceruloplasmin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012611 ! abnormal ceruloplasmin level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:19:55Z

[Term]
id: MP:0012614
name: abnormal circulating factor IX level
def: "any anomaly in the concentration in the blood of coagulation factor IX, a member of the peptidase family S1" [https://en.wikipedia.org/wiki/Factor_IX]
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012615
name: decreased circulating factor IX level
def: "decrease in the concentration in the blood of coagulation factor IX, a member of the peptidase family S1" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012614 ! abnormal circulating factor IX level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012616
name: increased circulating factor IX level
def: "increase in the concentration in the blood of coagulation factor IX, a member of the peptidase family S1" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012614 ! abnormal circulating factor IX level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012617
name: abnormal circulating factor X level
def: "any anomaly in the concentration in the blood of coagulation factor X, a serine endopeptidase that is part of the common pathway in the coagulation cascade" [https://en.wikipedia.org/wiki/Factor_X]
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012618
name: decreased circulating factor X level
def: "decrease in the concentration in the blood of coagulation factor X" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012617 ! abnormal circulating factor X level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012619
name: increased circulating factor X level
def: "increase in the concentration in the blood of coagulation factor X" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012617 ! abnormal circulating factor X level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012620
name: abnormal circulating factor XIII level
def: "any anomaly in the concentration in the blood of coagulation factor 13, also known as fibrin stabilizing factor, that when activated cross-links fibrin polymers and solidifies the clot" [https://en.wikipedia.org/wiki/Factor_XIII]
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012621
name: decreased circulating factor XIII level
def: "decrease in the concentration in the blood of coagulation factor 13" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating factor XIII level" EXACT []
is_a: MP:0012620 ! abnormal circulating factor XIII level
is_a: MP:0014451 ! decreased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012622
name: increased circulating factor XIII level
def: "increase in the concentration in the blood of coagulation factor 13" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating factor XIII level" EXACT []
is_a: MP:0012620 ! abnormal circulating factor XIII level
is_a: MP:0014450 ! increased circulating enzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:21:28Z

[Term]
id: MP:0012623
name: abnormal acetylcholinesterase activity
def: "anomaly in the catalysis of the reaction: acetylcholine + H2O = choline + acetate" [GO:0003990]
synonym: "abnormal acetyl.beta-methylcholinesterase activity" EXACT []
synonym: "abnormal acetylcholine acetylhydrolase activity" EXACT []
synonym: "abnormal acetylcholine hydrolase activity" EXACT []
synonym: "abnormal acetylthiocholinesterase activity" EXACT []
synonym: "abnormal choline esterase I activity" EXACT []
synonym: "abnormal true cholinesterase activity" EXACT []
is_a: MP:0020029 ! abnormal cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:40:02Z

[Term]
id: MP:0012624
name: decreased acetylcholinesterase activity
def: "decreased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate" [GO:0003990]
synonym: "decreased acetyl.beta-methylcholinesterase activity" EXACT []
synonym: "decreased acetylcholine acetylhydrolase activity" EXACT []
synonym: "decreased acetylcholine hydrolase activity" EXACT []
synonym: "decreased acetylthiocholinesterase activity" EXACT []
synonym: "decreased choline esterase I activity" EXACT []
synonym: "decreased true cholinesterase activity" EXACT []
is_a: MP:0012623 ! abnormal acetylcholinesterase activity
is_a: MP:0020034 ! decreased cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:40:02Z

[Term]
id: MP:0012625
name: increased acetylcholinesterase activity
def: "increased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate" [GO:0003990]
synonym: "increased acetyl.beta-methylcholinesterase activity" EXACT []
synonym: "increased acetylcholine acetylhydrolase activity" EXACT []
synonym: "increased acetylcholine hydrolase activity" EXACT []
synonym: "increased acetylthiocholinesterase activity" EXACT []
synonym: "increased choline esterase I activity" EXACT []
synonym: "increased true cholinesterase activity" EXACT []
is_a: MP:0012623 ! abnormal acetylcholinesterase activity
is_a: MP:0020033 ! increased cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:40:02Z

[Term]
id: MP:0012626
name: decreased brain acetylcholinesterase activity
def: "decreased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate in the brain" [GO:0003990]
is_a: MP:0004811 ! abnormal neuron physiology
is_a: MP:0012624 ! decreased acetylcholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:40:02Z

[Term]
id: MP:0012627
name: increased brain acetylcholinesterase activity
def: "increased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate in the brain" [GO:0003990]
is_a: MP:0004811 ! abnormal neuron physiology
is_a: MP:0012625 ! increased acetylcholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-04T11:40:02Z

[Term]
id: MP:0012628
name: abnormal glutathione reductase level
def: "any anomaly in the amount of the enzyme that catalyzes the oxidation of glutathione to glutathione disulfide in the presence of NADP+" [MESH:D08.811.682.667.092]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:49:47Z

[Term]
id: MP:0012629
name: decreased glutathione reductase level
def: "decrease in the amount of the enzyme that catalyzes the oxidation of glutathione to glutathione disulfide in the presence of NADP+" [MESH:D08.811.682.667.092]
is_a: MP:0012628 ! abnormal glutathione reductase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:49:47Z

[Term]
id: MP:0012630
name: increased glutathione reductase level
def: "increase in the amount of the enzyme that catalyzes the oxidation of glutathione to glutathione disulfide in the presence of NADP+" [MESH:D08.811.682.667.092]
is_a: MP:0012628 ! abnormal glutathione reductase level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:49:47Z

[Term]
id: MP:0012631
name: decreased kidney glutathione reductase level
def: "decrease in the amount of the enzyme that catalyzes the oxidation of glutathione to glutathione disulfide in the presence of NADP+ in the kidney" [MESH:D08.811.682.667.092]
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0012629 ! decreased glutathione reductase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:49:47Z

[Term]
id: MP:0012632
name: increased kidney glutathione reductase level
def: "increase in the amount of the enzyme that catalyzes the oxidation of glutathione to glutathione disulfide in the presence of NADP+ in the kidney" [MESH:D08.811.682.667.092]
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0012630 ! increased glutathione reductase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:49:47Z

[Term]
id: MP:0012633
name: increased phospholipase A2 level
def: "increase in the amount of any of the enzymes that hydrolize the acyl group attached to the two-position of phosphoglycerides" [MESH:D08.811.277.352.100.680.750.937]
is_a: MP:0012044 ! abnormal phospholipase A2 level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:51:05Z

[Term]
id: MP:0012634
name: decreased phospholipase A2 level
def: "decrease in the amount of any of the enzymes that hydrolize the acyl group attached to the two-position of phosphoglycerides" [MESH:D08.811.277.352.100.680.750.937]
is_a: MP:0012044 ! abnormal phospholipase A2 level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:51:05Z

[Term]
id: MP:0012635
name: abnormal monoamine oxidase activity
def: "anomaly in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia" [GO:0097621]
synonym: "abnormal amine:oxygen oxidoreductase (deaminating) activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012636
name: decreased monoamine oxidase activity
def: "reduction in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia" [GO:0097621]
is_a: MP:0012635 ! abnormal monoamine oxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012637
name: increased monoamine oxidase activity
def: "increase in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia" [GO:0097621]
is_a: MP:0012635 ! abnormal monoamine oxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012638
name: decreased brain monoamine oxidase activity
def: "reduction in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 in the brain; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia" [GO:0097621]
is_a: MP:0012636 ! decreased monoamine oxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012639
name: increased brain monoamine oxidase activity
def: "increase in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 in brain tissue; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia" [GO:0097621]
is_a: MP:0012637 ! increased monoamine oxidase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012640
name: abnormal benzo (alpha) pyrene hydroxylase activity
def: "anomaly in the ability to catalyze the reaction that adds -OH to a poly aromatic hydrocarbon substrate" [https://doi.org/10.1093/toxsci/55.2.320]
synonym: "abnormal benz (alpha) pyrene hydroxylase activity" EXACT []
synonym: "abnormal BPH activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012641
name: decreased benzo (alpha) pyrene hydroxylase activity
def: "reduced ability to catalyze the reaction that adds -OH to a poly aromatic hydrocarbon substrate" [https://doi.org/10.1093/toxsci/55.2.320]
synonym: "decreased benz (alpha) pyrene hydroxylase activity" EXACT []
synonym: "reduced BPH activity" EXACT []
is_a: MP:0012640 ! abnormal benzo (alpha) pyrene hydroxylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012642
name: increased benzo (alpha) pyrene hydroxylase activity
def: "greater ability to catalyze the reaction that adds -OH to a poly aromatic hydrocarbon substrate" [https://doi.org/10.1093/toxsci/55.2.320]
synonym: "increased benz (alpha) pyrene hydroxylase activity" EXACT []
synonym: "increased BPH activity" EXACT []
is_a: MP:0012640 ! abnormal benzo (alpha) pyrene hydroxylase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012643
name: abnormal 5-aminolevulinate synthase activity
def: "any anomaly in the ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA" [GO:0003870]
synonym: "abnormal 5-aminolevulinate synthetase activity" EXACT []
synonym: "abnormal 5-aminolevulinic acid synthase activity" EXACT []
synonym: "abnormal 5-aminolevulinic acid synthetase activity" EXACT []
synonym: "abnormal ALA synthase activity" EXACT []
synonym: "abnormal ALA synthetase activity" EXACT []
synonym: "abnormal ALAS activity" EXACT []
synonym: "abnormal alpha-aminolevulinic acid synthase activity" EXACT []
synonym: "abnormal aminolevulinate synthase activity" EXACT []
synonym: "abnormal aminolevulinate synthetase activity" EXACT []
synonym: "abnormal aminolevulinic acid synthase activity" EXACT []
synonym: "abnormal aminolevulinic acid synthetase activity" EXACT []
synonym: "abnormal aminolevulinic synthetase activity" EXACT []
synonym: "abnormal delta-ALA synthetase activity" EXACT []
synonym: "abnormal delta-aminolevulinate synthase activity" EXACT []
synonym: "abnormal delta-aminolevulinate synthetase activity" EXACT []
synonym: "abnormal delta-aminolevulinic acid synthase activity" EXACT []
synonym: "abnormal delta-aminolevulinic acid synthetase activity" EXACT []
synonym: "abnormal delta-aminolevulinic synthetase activity" EXACT []
synonym: "abnormal succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012644
name: decreased 5-aminolevulinate synthase activity
def: "reduced ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA" [GO:0003870]
synonym: "decreased 5-aminolevulinate synthetase activity" EXACT []
synonym: "decreased 5-aminolevulinic acid synthase activity" EXACT []
synonym: "decreased 5-aminolevulinic acid synthetase activity" EXACT []
synonym: "decreased ALA synthase activity" EXACT []
synonym: "decreased ALA synthetase activity" EXACT []
synonym: "decreased ALAS activity" EXACT []
synonym: "decreased alpha-aminolevulinic acid synthase activity" EXACT []
synonym: "decreased aminolevulinate synthase activity" EXACT []
synonym: "decreased aminolevulinate synthetase activity" EXACT []
synonym: "decreased aminolevulinic acid synthase activity" EXACT []
synonym: "decreased aminolevulinic acid synthetase activity" EXACT []
synonym: "decreased aminolevulinic synthetase activity" EXACT []
synonym: "decreased delta-ALA synthetase activity" EXACT []
synonym: "decreased delta-aminolevulinate synthase activity" EXACT []
synonym: "decreased delta-aminolevulinate synthetase activity" EXACT []
synonym: "decreased delta-aminolevulinic acid synthase activity" EXACT []
synonym: "decreased delta-aminolevulinic acid synthetase activity" EXACT []
synonym: "decreased delta-aminolevulinic synthetase activity" EXACT []
synonym: "decreased succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT []
is_a: MP:0012643 ! abnormal 5-aminolevulinate synthase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012645
name: increased 5-aminolevulinate synthase activity
def: "increased ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA" [GO:0003870]
synonym: "increased 5-aminolevulinate synthetase activity" EXACT []
synonym: "increased 5-aminolevulinic acid synthase activity" EXACT []
synonym: "increased 5-aminolevulinic acid synthetase activity" EXACT []
synonym: "increased ALA synthase activity" EXACT []
synonym: "increased ALA synthetase activity" EXACT []
synonym: "increased ALAS activity" EXACT []
synonym: "increased alpha-aminolevulinic acid synthase activity" EXACT []
synonym: "increased aminolevulinate synthase activity" EXACT []
synonym: "increased aminolevulinate synthetase activity" EXACT []
synonym: "increased aminolevulinic acid synthase activity" EXACT []
synonym: "increased aminolevulinic acid synthetase activity" EXACT []
synonym: "increased aminolevulinic synthetase activity" EXACT []
synonym: "increased delta-ALA synthetase activity" EXACT []
synonym: "increased delta-aminolevulinate synthase activity" EXACT []
synonym: "increased delta-aminolevulinate synthetase activity" EXACT []
synonym: "increased delta-aminolevulinic acid synthase activity" EXACT []
synonym: "increased delta-aminolevulinic acid synthetase activity" EXACT []
synonym: "increased delta-aminolevulinic synthetase activity" EXACT []
synonym: "increased succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT []
is_a: MP:0012643 ! abnormal 5-aminolevulinate synthase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012646
name: abnormal urokinase activity
def: "any anomaly in the ability of the serine protease to catalyze the conversion of plasminogen to active plasmin" [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/urokinase, https://www.sigmaaldrich.com/US/en/product/sigma/mak185]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012647
name: decreased urokinase activity
def: "reduction in the ability of the serine protease to catalyze the conversion of plasminogen to active plasmin" [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/urokinase]
is_a: MP:0012646 ! abnormal urokinase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012648
name: increased urokinase activity
def: "increase in the ability of the serine protease to catalyze the conversion of plasminogen to active plasmin" [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/urokinase]
is_a: MP:0012646 ! abnormal urokinase activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:52:26Z

[Term]
id: MP:0012649
name: abnormal catalase level
def: "any anomaly in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen" [MESH:D002374]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012650
name: abnormal erythrocyte catalase level
def: "any anomaly in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in red blood cells" [MESH:D002374]
is_a: MP:0002447 ! abnormal erythrocyte morphology
is_a: MP:0012649 ! abnormal catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012651
name: abnormal kidney catalase level
def: "any anomaly in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in the kidney" [MESH:D002374]
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0012649 ! abnormal catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012652
name: decreased catalase level
def: "reduction in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen" [MESH:D002374]
is_a: MP:0012649 ! abnormal catalase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012653
name: decreased erythrocyte catalase level
def: "reduction in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in red blood cells" [MESH:D002374]
is_a: MP:0012650 ! abnormal erythrocyte catalase level
is_a: MP:0012652 ! decreased catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012654
name: decreased kidney catalase level
def: "reduction in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in the kidneys" [MESH:D002374]
is_a: MP:0012651 ! abnormal kidney catalase level
is_a: MP:0012652 ! decreased catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012655
name: increased catalase level
def: "increase in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen" [MESH:D002374]
is_a: MP:0012649 ! abnormal catalase level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012656
name: increased erythrocyte catalase level
def: "increase in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in red blood cells" [MESH:D002374]
is_a: MP:0012650 ! abnormal erythrocyte catalase level
is_a: MP:0012655 ! increased catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012657
name: increased kidney catalase level
def: "increase in the amount of the oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen in the kidneys" [MESH:D002374]
is_a: MP:0012651 ! abnormal kidney catalase level
is_a: MP:0012655 ! increased catalase level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T21:56:26Z

[Term]
id: MP:0012658
name: abnormal superoxide dismutase level
def: "any anomaly in the amount of the oxidoreductase that catalyzes the reaction between superoxides and hydrogen to yield molecular oxygen and hydrogen peroxide" [MESH:D013482]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:01:07Z

[Term]
id: MP:0012659
name: decreased superoxide dismutase level
def: "reduction in the amount of the oxidoreductase that catalyzes the reaction between superoxides and hydrogen to yield molecular oxygen and hydrogen peroxide" [MESH:D013482]
is_a: MP:0012658 ! abnormal superoxide dismutase level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:01:07Z

[Term]
id: MP:0012660
name: increased superoxide dismutase level
def: "increase in the amount of the oxidoreductase that catalyzes the reaction between superoxides and hydrogen to yield molecular oxygen and hydrogen peroxide" [MESH:D013482]
is_a: MP:0012658 ! abnormal superoxide dismutase level
is_a: MP:0014448 ! increased enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:01:07Z

[Term]
id: MP:0012661
name: decreased circulating ceruloplasmin level
def: "decreased amount in the blood of any of ceruloplasmin, a ferroxidase enzyme" [http://en.wikipedia.org/wiki/Ceruloplasmin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012612 ! decreased ceruloplasmin level
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0020986 ! abnormal circulating ceruloplasmin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012662
name: increased circulating ceruloplasmin level
def: "increased amount in the blood of any of ceruloplasmin, a ferroxidase enzyme" [http://en.wikipedia.org/wiki/Ceruloplasmin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012613 ! increased ceruloplasmin level
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0020986 ! abnormal circulating ceruloplasmin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012663
name: decreased haptoglobin level
def: "decreased amount of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity" [http://en.wikipedia.org/wiki/Haptoglobin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0013215 ! abnormal haptoglobin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012664
name: decreased circulating haptoglobin level
def: "decreased amount in the blood of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity" [http://en.wikipedia.org/wiki/Haptoglobin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012663 ! decreased haptoglobin level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012665
name: increased haptoglobin level
def: "increased amount of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity" [http://en.wikipedia.org/wiki/Haptoglobin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0013215 ! abnormal haptoglobin level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012666
name: increased circulating haptoglobin level
def: "increased amount in the blood of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity" [http://en.wikipedia.org/wiki/Haptoglobin, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012665 ! increased haptoglobin level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T22:03:22Z

[Term]
id: MP:0012667
name: split sternal manubrium
def: "the appearance of an abnormal division of the cranial most segment of the sternum" [https://orcid.org/0000-0002-6490-7723]
synonym: "bifid sternal manubrium" EXACT []
synonym: "bifurcated sternal manubrium" EXACT []
synonym: "fissure of the sternal manubrium" EXACT []
is_a: MP:0008785 ! abnormal sternum manubrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T23:27:12Z

[Term]
id: MP:0012668
name: absent sternal manubrium
def: "absence of the cranial most segment of the sternum" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008785 ! abnormal sternum manubrium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T23:27:12Z

[Term]
id: MP:0012669
name: abnormal somite segmentation clock
def: "anomaly or loss of the oscillatory mechanism governed by periodic shifts in gene expression and operating in the presomitic mesoderm that drives the regular periodicity with which somites are formed in the course of vertebrate segmentation. The total number of somites formed and the periodicity with which they are produced are species-specific parameters (e.g. humans have 33 somites with a somitogenesis period of approximately 6 hours while mice have 65 somites with a period of approximately 2 hours)" [http://en.wikipedia.org/wiki/Somitogenesis, https://orcid.org/0000-0002-6490-7723, PMID:22274695]
is_a: MP:0001688 ! abnormal somite development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T23:31:11Z

[Term]
id: MP:0012670
name: prolonged somite segmentation clock period
def: "extension of the somite segmentation clock period; may lead to decreased numbers of somites and their resultant vertebrae" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended somite segmentation clock period" EXACT []
synonym: "prolonged period of somite formation" EXACT []
synonym: "prolonged somitogenesis period" EXACT []
is_a: MP:0012669 ! abnormal somite segmentation clock
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-05T23:33:48Z

[Term]
id: MP:0012671
name: retina spots
def: "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [https://orcid.org/0000-0003-3691-0324]
synonym: "retinal spots" EXACT []
synonym: "white dot syndrome" BROAD []
synonym: "white retinal patches" BROAD []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-01-09T15:34:36Z

[Term]
id: MP:0012672
name: enlarged trachea
def: "increased size of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased trachea size" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-14T10:28:46Z

[Term]
id: MP:0012673
name: aberrant crypt foci
def: "a neoplastic lesion in which large, thick clusters of abnormal tube-like glands are found in the lining of the colon and rectum; aberrant crypt foci are precursors of colorectal polyps, adenoma and colon cancer" [MGI:acv]
synonym: "ACF" EXACT []
is_a: MP:0004842 ! abnormal large intestine crypts of Lieberkuhn morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-14T13:11:00Z

[Term]
id: MP:0012674
name: tomacula
def: "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [https://orcid.org/0000-0003-4606-0597]
synonym: "excessive myelin folding" BROAD []
synonym: "myelin outfoldings" BROAD []
is_a: MP:0003871 ! abnormal myelin sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
creation_date: 2014-03-14T13:53:09Z

[Term]
id: MP:0012675
name: enlarged floor plate
def: "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [https://orcid.org/0000-0002-6490-7723]
synonym: "expanded floor plate" EXACT []
synonym: "increased floor plate size" EXACT []
synonym: "widened floor plate" EXACT []
is_a: MP:0000925 ! abnormal floor plate morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T09:26:32Z

[Term]
id: MP:0012676
name: dilated brain ventricle
def: "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "brain ventricle dilation" EXACT []
synonym: "brain ventricular dilation" EXACT []
synonym: "cerebral ventricle dilation" EXACT []
synonym: "cerebral ventricular dilation" EXACT []
synonym: "dilated brain ventricles" EXACT []
synonym: "dilated cerebral ventricle" EXACT []
synonym: "dilated cerebral ventricles" EXACT []
is_a: MP:0000822 ! abnormal brain ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:17:54Z

[Term]
id: MP:0012677
name: absent brain ventricles
def: "absence of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cerebral ventricles" EXACT []
synonym: "cerebral ventricular agenesis" EXACT []
is_a: MP:0000822 ! abnormal brain ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:23:16Z

[Term]
id: MP:0012678
name: absent fourth ventricle
def: "absence of the irregularly shaped cavity in the rhombencephalon, normally located between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; the fourth ventricle is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent 4th ventricle" EXACT []
synonym: "absent IVth ventricle" EXACT []
synonym: "absent rhombencephalic ventricle" EXACT []
synonym: "absent ventricle of rhombencephalon" EXACT []
synonym: "absent ventriculus quartus" EXACT []
is_a: MP:0000828 ! abnormal fourth ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:24:13Z

[Term]
id: MP:0012679
name: absent third ventricle
def: "absence of the narrow cleft located inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent 3rd ventricle" EXACT []
is_a: MP:0000826 ! abnormal third ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:27:59Z

[Term]
id: MP:0012680
name: absent lateral ventricles
def: "absence of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; lateral ventricles are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ventricle of cerebral hemisphere" EXACT []
synonym: "absent ventriculus lateralis" EXACT []
is_a: MP:0000823 ! abnormal lateral ventricle morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:29:20Z

[Term]
id: MP:0012681
name: collapsed brain ventricles
def: "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord are severely reduced in volume or area, possibly due to reduced or absent cerebrospinal fluid production; collapsed ventricles can be a sign of increased intracranial pressure and accumulation of water in the brain parenchyma" [https://orcid.org/0000-0002-6490-7723]
synonym: "collapsed cerebral ventricles" EXACT []
is_a: MP:0013228 ! brain ventricle stenosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T14:38:36Z

[Term]
id: MP:0012682
name: abnormal septal nucleus morphology
def: "any structural anomaly of the groups of neural nuclei situated in the septal region which have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal septal nuclear complex morphology" EXACT []
synonym: "abnormal septal nuclei" EXACT []
is_a: MP:0012003 ! abnormal septum of telencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T15:46:27Z

[Term]
id: MP:0012683
name: absent telencephalon
def: "absence of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures" [https://orcid.org/0000-0002-6490-7723]
synonym: "atelencephaly" EXACT [PMID:25546391]
is_a: MP:0000787 ! abnormal telencephalon morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T16:06:53Z

[Term]
id: MP:0012684
name: abnormal pleural cavity morphology
def: "any structural anomaly of the potential space between the two pleurae (visceral and parietal) of the lungs; the pleural cavity, with its associated pleurae, aids optimal functioning of the lungs during breathing; it normally contains a thin film of serous fluid which lubricates the opposed pleural membranes so that they can glide smoothly against one another during ventilation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intrapleural space morphology" EXACT []
synonym: "abnormal pleural space morphology" EXACT []
is_a: MP:0002132 ! abnormal respiratory system morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T21:58:09Z

[Term]
id: MP:0012685
name: abnormal primitive streak elongation
def: "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [https://orcid.org/0000-0002-6490-7723]
comment: In mouse this is completed by E7.5.
is_a: MP:0008932 ! abnormal embryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:27:09Z

[Term]
id: MP:0012686
name: everted embryonic neuroepithelium
def: "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [https://orcid.org/0000-0002-6490-7723]
synonym: "embryonic neuroepithelium eversion" EXACT []
synonym: "everted embryonic neural ectoderm" EXACT []
synonym: "everted embryonic neuroectoderm" EXACT []
synonym: "everted neural folds" EXACT []
synonym: "neural fold eversion" EXACT []
is_a: MP:0004261 ! abnormal embryonic neuroepithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:37:14Z

[Term]
id: MP:0012687
name: abnormal heart atria weight
def: "abnormal average weight of both the left and right atria" [MPD:Molly]
is_a: MP:0031576 ! abnormal heart atrium size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:53:02Z

[Term]
id: MP:0012688
name: abnormal heart ventricles weight
def: "abnormal average weight of both the left and right ventricles together" [MPD:Molly]
is_a: MP:0031543 ! abnormal heart ventricle size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:55:47Z

[Term]
id: MP:0012689
name: abnormal adrenal gland weight
def: "abnormal weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [MPD:Molly]
is_a: MP:0000639 ! abnormal adrenal gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:56:56Z

[Term]
id: MP:0012690
name: abnormal stride length
def: "abnormal average distance between steps" [MPD:Molly]
is_a: MP:0001406 ! abnormal gait
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-19T22:59:05Z

[Term]
id: MP:0012691
name: abnormal acetaminophen metabolism
def: "altered ability to metabolize acetaminophen, used as a non-narcotic analgesic, a non-steroidal anti-inflammatory and an anti-pyretic agent" [GO:1901554, MPD:Molly]
synonym: "abnormal APAP metabolism" EXACT []
synonym: "abnormal paracetamol metabolism" EXACT []
synonym: "abnormal Tylenol metabolism" EXACT []
is_a: MP:0013275 ! abnormal xenobiotic metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012692
name: abnormal fluoxetine metabolism
def: "altered ability to metabolize fluoxetine, an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class which is commonly used to treat various psychiatric disorders" [MPD:Molly]
synonym: "abnormal Prozac metabolism" EXACT []
is_a: MP:0013275 ! abnormal xenobiotic metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012693
name: abnormal haloperidol metabolism
def: "altered ability to metabolize haloperidol, a butyrophenone-type antipsychotic medication used in the treatment of schizophrenia, acute psychosis, and delirium" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012694
name: abnormal lithium metabolism
def: "altered ability to metabolize lithium, commonly used as a mood-stabilizing drug, primarily in the treatment of bipolar disorder in the treatment of both depressive and particularly of mania episodes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012695
name: abnormal nicotine metabolism
def: "altered ability to metabolize nicotine, a potent parasympathomimetic alkaloid that acts as a stimulant in mammals; nicotine activates the mesolimbic pathway in the central nervous system, which regulates feelings of reward and pleasure, and this response is thought to contribute to the addictive nature of nicotine" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012696
name: abnormal trichloroethene metabolism
def: "altered ability to metabolize trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, used as an industrial solvent, and was used a anesthetic and as an inhaled obstetrical analgesic" [MPD:Molly]
synonym: "abnormal trichloroethylene metabolism" EXACT []
is_a: MP:0013275 ! abnormal xenobiotic metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T10:22:37Z

[Term]
id: MP:0012697
name: abnormal maternal body weight gain
def: "anomaly in the expected amount of female body weight gain during pregnancy" [MPD:Molly]
is_a: MP:0009661 ! abnormal pregnancy
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T11:21:56Z

[Term]
id: MP:0012698
name: increased maternal body weight gain
def: "greater than the expected amount of female body weight gain during pregnancy" [MPD:Molly]
is_a: MP:0012697 ! abnormal maternal body weight gain
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T11:23:17Z

[Term]
id: MP:0012699
name: decreased maternal body weight gain
def: "reduction in the expected amount of female body weight gain during pregnancy" [MPD:Molly]
synonym: "reduced maternal body weight gain" EXACT []
is_a: MP:0012697 ! abnormal maternal body weight gain
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T11:23:31Z

[Term]
id: MP:0012700
name: abnormal endocardial heart tube morphology
def: "any structural anomaly of the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal embryonic heart tube morphology" EXACT []
synonym: "abnormal endocardial tube morphology" EXACT []
synonym: "abnormal endocardial tubes" EXACT []
is_a: MP:0000267 ! abnormal heart development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T11:36:07Z

[Term]
id: MP:0012701
name: increased embryonic neuroepithelium apoptosis
def: "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased embryonic neural ectoderm apoptosis" EXACT []
synonym: "increased embryonic neuroectoderm apoptosis" EXACT []
synonym: "increased neural tube neuroepithelium apoptosis" EXACT []
is_a: MP:0012505 ! increased neural tube apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T11:59:04Z

[Term]
id: MP:0012702
name: increased embryonic neuroepithelium thickness
def: "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased embryonic neural ectoderm width" EXACT []
synonym: "increased embryonic neuroectoderm width" EXACT []
synonym: "increased embryonic neuroepithelium width" EXACT []
synonym: "increased neural tube neuroepithelium width" EXACT []
synonym: "thickened embryonic neural ectoderm" EXACT []
synonym: "thickened embryonic neuroectoderm" EXACT []
synonym: "thickened embryonic neuroepithelium" EXACT []
synonym: "thickened neural tube neuroepithelium" EXACT []
is_a: MP:0004261 ! abnormal embryonic neuroepithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T12:25:34Z

[Term]
id: MP:0012703
name: decreased embryonic neuroepithelium thickness
def: "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased embryonic neural ectoderm width" EXACT []
synonym: "decreased embryonic neuroectoderm width" EXACT []
synonym: "decreased embryonic neuroepithelium width" EXACT []
synonym: "decreased neural tube neuroepithelium width" EXACT []
synonym: "reduced embryonic neural ectoderm width" EXACT []
synonym: "reduced embryonic neuroectoderm width" EXACT []
synonym: "reduced embryonic neuroepithelium thickness" EXACT []
synonym: "reduced embryonic neuroepithelium width" EXACT []
synonym: "reduced neural tube neuroepithelium width" EXACT []
synonym: "thinned embryonic neural ectoderm" EXACT []
synonym: "thinned embryonic neuroectoderm" EXACT []
synonym: "thinned embryonic neuroepithelium" EXACT []
synonym: "thinned neural tube neuroepithelium" EXACT []
is_a: MP:0004261 ! abnormal embryonic neuroepithelium morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T12:25:45Z

[Term]
id: MP:0012704
name: abnormal embryonic neuroepithelial cell proliferation
def: "any anomaly in the ability of the cells of the embryonic neuroepithelium to undergo expansion by cell division" [CL:0000710, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal embryonic neural ectoderm proliferation" EXACT []
synonym: "abnormal embryonic neuroectoderm proliferation" EXACT []
synonym: "abnormal embryonic neuroepithelium proliferation" EXACT []
synonym: "abnormal neural tube neuroepithelium proliferation" EXACT []
synonym: "abnormal neurecto-epithelial cell proliferation" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T12:49:46Z

[Term]
id: MP:0012705
name: increased embryonic neuroepithelial cell proliferation
def: "increase in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, https://orcid.org/0000-0002-6490-7723]
synonym: "increased embryonic neural ectoderm proliferation" EXACT []
synonym: "increased embryonic neuroectoderm proliferation" EXACT []
synonym: "increased embryonic neuroepithelium proliferation" EXACT []
synonym: "increased neural tube neuroepithelium proliferation" EXACT []
synonym: "increased neurecto-epithelial cell proliferation" EXACT []
is_a: MP:0012704 ! abnormal embryonic neuroepithelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T12:51:28Z

[Term]
id: MP:0012706
name: decreased embryonic neuroepithelial cell proliferation
def: "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased embryonic neural ectoderm proliferation" EXACT []
synonym: "decreased embryonic neuroectoderm proliferation" EXACT []
synonym: "decreased embryonic neuroepithelium proliferation" EXACT []
synonym: "decreased neural tube neuroepithelium proliferation" EXACT []
synonym: "decreased neurecto-epithelial cell proliferation" EXACT []
synonym: "reduced embryonic neural ectoderm proliferation" EXACT []
synonym: "reduced embryonic neuroectoderm proliferation" EXACT []
synonym: "reduced embryonic neuroepithelium proliferation" EXACT []
synonym: "reduced neural tube neuroepithelium proliferation" EXACT []
synonym: "reduced neurecto-epithelial cell proliferation" EXACT []
is_a: MP:0012704 ! abnormal embryonic neuroepithelial cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T12:51:49Z

[Term]
id: MP:0012707
name: incomplete caudal neuropore closure
def: "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [https://orcid.org/0000-0002-6490-7723]
synonym: "incomplete caudal neural tube closure" EXACT []
synonym: "incomplete posterior neural tube closure" EXACT []
synonym: "incomplete posterior neuropore closure" EXACT []
synonym: "incomplete spinal neural tube closure" RELATED []
synonym: "open caudal neuropore" EXACT []
synonym: "open posterior neuropore" EXACT []
is_a: MP:0003720 ! abnormal neural tube closure
is_a: MP:0012544 ! abnormal caudal neuropore morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T13:40:36Z

[Term]
id: MP:0012708
name: delayed rostral neuropore closure
def: "a delay in the fusion of the cephalic neural folds" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed anterior cephalic closure" EXACT []
synonym: "delayed anterior neural tube closure" EXACT []
synonym: "delayed cephalic closure" EXACT []
synonym: "delayed cranial neural fold fusion" EXACT []
synonym: "delayed head fold fusion" EXACT []
synonym: "delayed headfold fusion" EXACT []
synonym: "delayed rostral neural tube closure" EXACT []
is_a: MP:0002621 ! delayed neural tube closure
is_a: MP:0008932 ! abnormal embryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T13:45:55Z

[Term]
id: MP:0012709
name: delayed caudal neuropore closure
def: "a delay in the joining together of the neural folds of the caudal opening of the neural tube" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed posterior neuropore closure" EXACT []
is_a: MP:0002621 ! delayed neural tube closure
is_a: MP:0008932 ! abnormal embryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T13:48:29Z

[Term]
id: MP:0012710
name: diastematomyelia
def: "a rare congenital anomaly that results in the splitting of the spinal cord in a longitudinal direction, usually at the level of the upper lumbar vertebra; this condition occurs in the presence of an osseous (bone), cartilaginous or fibrous septum in the central portion of the spinal canal which then produces a complete or incomplete sagittal division of the spinal cord into two hemicords, each half being surrounded by a dural sac; when the split does not reunite distally to the spur, the condition is referred to as a diplomyelia" [https://orcid.org/0000-0002-6490-7723]
synonym: "diastomyelia" EXACT []
is_a: MP:0000955 ! abnormal spinal cord morphology
is_a: MP:0005297 ! spina bifida occulta
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:10:17Z

[Term]
id: MP:0012711
name: diplomyelia
def: "true duplication of the spinal cord; each cord has two dorsal and two ventral horns and paired nerve roots, but the two cords are contained within a single dural sac" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000955 ! abnormal spinal cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:15:23Z

[Term]
id: MP:0012712
name: spinal cord degeneration
def: "a retrogressive impairment of function or destruction of the spinal cord" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000955 ! abnormal spinal cord morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:18:42Z

[Term]
id: MP:0012713
name: abnormal ventral ectodermal ridge morphology
def: "any structural anomaly of the morphologically distinct group of ectodermal cells that serves as an important signaling center in the mouse tail-bud following completion of gastrulation, and contains progenitor cells that contribute to the ventral midline ectoderm of the tail; ablation of the VER leads to defects in somitogenesis and tail elongation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal VER morphology" EXACT []
is_a: MP:0002861 ! abnormal tail bud morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:34:50Z

[Term]
id: MP:0012714
name: decreased ventral ectodermal ridge size
def: "reduced size of the morphologically distinct group of ectodermal cells that serves as an important signaling center in the mouse tail-bud following completion of gastrulation, and contains progenitor cells that contribute to the ventral midline ectoderm of the tail" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased VER size" EXACT []
synonym: "reduced ventral ectodermal ridge size" EXACT []
synonym: "reduced VER size" EXACT []
is_a: MP:0012713 ! abnormal ventral ectodermal ridge morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:35:19Z

[Term]
id: MP:0012715
name: abnormal hemangioblast morphology
def: "any structural anomaly of the pluripotent precursor cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands" [CL:0002418, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal haemangioblast morphology" EXACT []
is_a: MP:0011247 ! abnormal yolk sac hematopoietic stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:42:10Z

[Term]
id: MP:0012716
name: abnormal hemangioblast number
def: "deviation from the normal numbers of pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands" [CL:0002418, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal haemangioblast number" EXACT []
is_a: MP:0012715 ! abnormal hemangioblast morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:44:33Z

[Term]
id: MP:0012717
name: increased hemangioblast number
def: "increased number of the pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands" [CL:0002418, https://orcid.org/0000-0002-6490-7723]
synonym: "increased haemangioblast number" EXACT []
is_a: MP:0012716 ! abnormal hemangioblast number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:44:33Z

[Term]
id: MP:0012718
name: decreased hemangioblast number
def: "reduced number of the pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands" [CL:0002418, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased haemangioblast number" EXACT []
synonym: "reduced haemangioblast number" EXACT []
synonym: "reduced hemangioblast number" EXACT []
is_a: MP:0012716 ! abnormal hemangioblast number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:44:33Z

[Term]
id: MP:0012719
name: abnormal neck morphology
def: "any structural anomaly of the part of body by which the head is connected to the trunk extending from the base of the cranium to the top of the shoulders" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005378 ! growth/size/body region phenotype
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T14:53:00Z

[Term]
id: MP:0012720
name: elongated neck
def: "increased length of the neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "extended neck region" EXACT []
synonym: "increased neck length" EXACT []
is_a: MP:0012719 ! abnormal neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T15:02:28Z

[Term]
id: MP:0012721
name: short neck
def: "decreased length of the neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased neck length" EXACT []
is_a: MP:0012719 ! abnormal neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T15:02:28Z

[Term]
id: MP:0012722
name: absent neck
def: "absence of the part of body by which the head is connected to the trunk extending from the base of the cranium to the top of the shoulders" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012719 ! abnormal neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T15:02:28Z

[Term]
id: MP:0012723
name: abnormal nuchal region morphology
def: "any structural anomaly of the posterior region of the neck, including the suboccipital region" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal posterior cervical region morphology" EXACT []
synonym: "abnormal posterior neck region" EXACT []
synonym: "abnormal regio cervicalis posterior morphology" EXACT []
synonym: "abnormal regio nuchalis morphology" EXACT []
synonym: "abnromal regio colli posterior morphology" EXACT []
is_a: MP:0012719 ! abnormal neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T15:02:28Z

[Term]
id: MP:0012724
name: absent head fold
def: "inability to form the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; the head fold constitutes the first body fold, and initiates brain, foregut and heart development" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent headfold" EXACT []
synonym: "failure of head fold formation" EXACT []
synonym: "failure of headfold formation" EXACT []
is_a: MP:0011257 ! abnormal head fold morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-20T15:02:28Z

[Term]
id: MP:0012725
name: small sebaceous gland
def: "decreased size of the sebum secreting glands of the hair shaft" [https://orcid.org/0000-0003-0431-8641]
synonym: "decreased sebaceous gland size" EXACT []
synonym: "reduced sebaceous gland size" EXACT []
is_a: MP:0000647 ! abnormal sebaceous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T11:41:22Z

[Term]
id: MP:0012726
name: abnormal uterine spiral artery morphology
def: "any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal coiled artery of the uterus" EXACT []
synonym: "abnormal decidual spiral artery morphology" EXACT []
synonym: "abnormal endometrial spiral artery morphology" EXACT []
synonym: "abnormal maternal spiral artery morphology" EXACT []
is_a: MP:0004256 ! abnormal maternal decidual layer morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T11:51:18Z

[Term]
id: MP:0012727
name: abnormal uterine spiral artery remodeling
def: "any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal decidual spiral artery remodeling" EXACT []
synonym: "abnormal endometrial spiral artery remodeling" EXACT []
synonym: "abnormal maternal spiral artery remodeling" EXACT []
synonym: "abnormal uterine spiral artery modification" EXACT []
is_a: MP:0009670 ! abnormal uterine angiogenesis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T11:53:50Z

[Term]
id: MP:0012728
name: abnormal somite border morphology
def: "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal inter-somite border morphology" EXACT []
synonym: "abnormal intersomitic boundary morphology" EXACT []
synonym: "abnormal intersomitic fissure morphology" EXACT []
synonym: "abnormal segmental border morphology" EXACT []
synonym: "abnormal somite border cell morphology" EXACT []
synonym: "abnormal somite boundary morphology" EXACT []
is_a: MP:0001688 ! abnormal somite development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T13:33:17Z

[Term]
id: MP:0012729
name: abnormal common carotid artery morphology
def: "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004181 ! abnormal carotid artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T15:56:12Z

[Term]
id: MP:0012730
name: abnormal internal carotid artery morphology
def: "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal internal carotid morphology" EXACT []
is_a: MP:0004181 ! abnormal carotid artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T15:56:12Z

[Term]
id: MP:0012731
name: abnormal external carotid artery morphology
def: "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal external carotid morphology" EXACT []
is_a: MP:0004181 ! abnormal carotid artery morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T15:56:12Z

[Term]
id: MP:0012732
name: abnormal perineural vascular plexus morphology
def: "any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal PNVP morphology" EXACT []
is_a: MP:0000259 ! abnormal vascular development
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-21T16:09:47Z

[Term]
id: MP:0012733
name: abnormal behavioral response to methamphetamine
def: "anomaly in the behavioral response induced by methamphetamine such as induced hyperactivity or stereotypic behavior" [MPD:Molly]
synonym: "abnormal behavioural response to methamphetamine" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T13:43:02Z

[Term]
id: MP:0012734
name: abnormal response to radiation
def: "any anomaly in the physiological changes induced by ionizing radiation such as UV light, X-rays, or gamma rays" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T13:45:54Z

[Term]
id: MP:0012735
name: abnormal response to exercise
def: "any anomaly in the physiological changes induced by controlled exercise" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T13:45:54Z

[Term]
id: MP:0012736
name: abnormal polar body morphology
def: "any structural anomaly of one of the small cells that are produced during the development of an oocyte and ultimately degenerate; a polar body contains one of the nuclei derived from the first or second meiotic division but little or no cytoplasm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006361 ! abnormal female germ cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:11:03Z

[Term]
id: MP:0012737
name: abnormal primary polar body morphology
def: "any structural anomaly of the small cell formed by the first meiotic division of oocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal first polar body morphology" EXACT []
synonym: "abnormal polocytus primarius morphology" EXACT []
is_a: MP:0012736 ! abnormal polar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:11:03Z

[Term]
id: MP:0012738
name: abnormal secondary polar body morphology
def: "any structural anomaly of the small cell formed by the second meiotic division of oocytes; in mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal polocytus secundarius morphology" EXACT []
synonym: "abnormal second polar body morphology" EXACT []
is_a: MP:0012736 ! abnormal polar body morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:11:03Z

[Term]
id: MP:0012739
name: abnormal anterior primitive streak morphology
def: "any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002231 ! abnormal primitive streak morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:17:32Z

[Term]
id: MP:0012740
name: abnormal posterior primitive streak morphology
def: "any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002231 ! abnormal primitive streak morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:17:32Z

[Term]
id: MP:0012741
name: decreased neural crest cell proliferation
def: "reduced ability of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased NCC proliferation" EXACT []
synonym: "reduced NCC proliferation" EXACT []
synonym: "reduced neural crest cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009842 ! abnormal neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:22:23Z

[Term]
id: MP:0012742
name: increased neural crest cell proliferation
def: "enhanced ability of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced NCC proliferation" EXACT []
synonym: "enhanced neural crest cell proliferation" EXACT []
synonym: "increased NCC proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0009842 ! abnormal neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:22:23Z

[Term]
id: MP:0012743
name: increased inner cell mass apoptosis
def: "increased number of cells of the blastocyst that develop into the body of the embryo undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced ICM apoptosis" EXACT []
synonym: "enhanced inner cell mass apoptosis" EXACT []
synonym: "increased ICM apoptosis" EXACT []
is_a: MP:0010380 ! abnormal inner cell mass apoptosis
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:26:05Z

[Term]
id: MP:0012744
name: increased neural crest cell apoptosis
def: "increased number of any population of neural crest cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced NCC apoptosis" EXACT []
synonym: "enhanced neural crest cell apoptosis" EXACT []
synonym: "increased NCC apoptosis" EXACT []
is_a: MP:0009844 ! abnormal neural crest cell apoptosis
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:29:32Z

[Term]
id: MP:0012745
name: abnormal neural crest cell physiology
def: "any functional anomaly in the complex process by which multipotent neural crest progenitors acquire migratory and invasive properties, emigrate from the dorsal aspect of the neural tube, migrate along distinct pathways, and differentiate into diverse cell types" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal NCC physiology" EXACT []
is_a: MP:0005621 ! abnormal cell physiology
is_a: MP:0008932 ! abnormal embryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T14:31:00Z

[Term]
id: MP:0012746
name: abnormal neural crest cell delamination
def: "any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal NCC delamination" EXACT []
synonym: "abnormal NCC emigration" EXACT []
synonym: "abnormal NCC individualization" EXACT []
synonym: "abnormal NCC segregation" EXACT []
synonym: "abnormal neural crest cell emigration" EXACT []
synonym: "abnormal neural crest cell individualization" EXACT []
synonym: "abnormal neural crest cell segregation" EXACT []
is_a: MP:0012745 ! abnormal neural crest cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T15:25:44Z

[Term]
id: MP:0012747
name: abnormal cardiac neural crest cell morphology
def: "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac NCC morphology" EXACT []
is_a: MP:0002925 ! abnormal cardiovascular development
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:24:58Z

[Term]
id: MP:0012748
name: increased cardiac neural crest cell number
def: "greater than expected number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cardiac NCC number" EXACT []
is_a: MP:0012747 ! abnormal cardiac neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:25:55Z

[Term]
id: MP:0012749
name: decreased cardiac neural crest cell number
def: "reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiac NCC number" EXACT []
synonym: "reduced cardiac NCC number" EXACT []
synonym: "reduced cardiac neural crest cell number" EXACT []
is_a: MP:0009843 ! decreased neural crest cell number
is_a: MP:0012747 ! abnormal cardiac neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:25:55Z

[Term]
id: MP:0012750
name: absent cardiac neural crest cells
def: "absence or loss of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia; ablation of cardiac NCCs results in cardiac outflow defects" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012749 ! decreased cardiac neural crest cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:25:55Z

[Term]
id: MP:0012751
name: impaired cardiac neural crest cell differentiation
def: "abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired cardiac NCC differentiation" RELATED []
is_a: MP:0012195 ! impaired neural crest cell differentiation
is_a: MP:0012747 ! abnormal cardiac neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:26:22Z

[Term]
id: MP:0012752
name: abnormal cardiac neural crest cell migration
def: "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:28:36Z

[Term]
id: MP:0012753
name: increased cardiac neural crest cell apoptosis
def: "increased number of cardiac neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cardiac NCC apoptosis" EXACT []
is_a: MP:0012744 ! increased neural crest cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-03-27T16:28:53Z

[Term]
id: MP:0012754
name: abnormal cranial neural crest cell morphology
def: "any structural anomaly of the neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [http://discovery.lifemapsc.com/in-vivo-development/neural-crest/cranial-neural-crest, http://embryology.med.unsw.edu.au/embryology/index.php?title=Neural_Crest_Development#Cranial_neural_crest, http://en.wikipedia.org/wiki/Cranial_neural_crest, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cephalic NCC morphology" EXACT []
synonym: "abnormal cephalic neural crest cell morphology" EXACT []
synonym: "abnormal cranial NCC morphology" EXACT []
synonym: "abnormal head NCC morphology" EXACT []
synonym: "abnormal head neural crest cell morphology" EXACT []
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:02:30Z

[Term]
id: MP:0012755
name: decreased cranial neural crest cell number
def: "reduction in the number of neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cranial NCC number" EXACT []
synonym: "reduced cranial NCC number" EXACT []
synonym: "reduced cranial neural crest cell number" EXACT []
is_a: MP:0009843 ! decreased neural crest cell number
is_a: MP:0012754 ! abnormal cranial neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:06:05Z

[Term]
id: MP:0012756
name: impaired cranial neural crest cell differentiation
def: "abnormal or arrest of differentiation or patterning of the cranial neural crest cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired cephalic NCC differentiation" EXACT []
synonym: "impaired cephalic neural crest cell differentiation" EXACT []
synonym: "impaired cranial NCC differentiation" EXACT []
synonym: "impaired head NCC differentiation" EXACT []
synonym: "impaired head neural crest cell differentiation" EXACT []
is_a: MP:0012754 ! abnormal cranial neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:06:05Z

[Term]
id: MP:0012757
name: abnormal cranial neural crest cell migration
def: "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cephalic NCC migration" EXACT []
synonym: "abnormal cephalic neural crest cell migration" EXACT []
synonym: "abnormal cranial NCC migration" EXACT []
synonym: "abnormal head NCC migration" EXACT []
synonym: "abnormal head neural crest cell migration" EXACT []
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:15:56Z

[Term]
id: MP:0012758
name: abnormal cranial neural crest cell proliferation
def: "any anomaly in the ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cranial NCC proliferation" EXACT []
is_a: MP:0009842 ! abnormal neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:17:46Z

[Term]
id: MP:0012759
name: increased cranial neural crest cell proliferation
def: "enhanced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cranial NCC proliferation" EXACT []
is_a: MP:0012742 ! increased neural crest cell proliferation
is_a: MP:0012758 ! abnormal cranial neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:18:35Z

[Term]
id: MP:0012760
name: decreased cranial neural crest cell proliferation
def: "reduced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cranial NCC proliferation" EXACT []
synonym: "reduced cranial NCC proliferation" EXACT []
synonym: "reduced cranial neural crest cell proliferation" EXACT []
is_a: MP:0012741 ! decreased neural crest cell proliferation
is_a: MP:0012758 ! abnormal cranial neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:18:35Z

[Term]
id: MP:0012761
name: increased cranial neural crest cell apoptosis
def: "increased number of cranial neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cephalic NCC apoptosis" EXACT []
synonym: "increased cephalic neural crest cell apoptosis" EXACT []
synonym: "increased cranial NCC apoptosis" EXACT []
synonym: "increased head NCC apoptosis" EXACT []
synonym: "increased head neural crest cell apoptosis" EXACT []
is_a: MP:0012744 ! increased neural crest cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T16:20:16Z

[Term]
id: MP:0012762
name: abnormal alpha-beta T cell morphology
def: "any structural anomaly of a T cell that expresses an alpha-beta T cell receptor complex" [CL:0000789]
subset: Sanger_Terms
synonym: "abnormal alpha-beta T lymphocyte morphology" EXACT []
synonym: "abnormal alpha-beta T-cell morphology" EXACT []
synonym: "abnormal alpha-beta T-lymphocyte morphology" EXACT []
is_a: MP:0008037 ! abnormal T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T21:48:51Z

[Term]
id: MP:0012763
name: abnormal alpha-beta T cell number
def: "aberrant number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
subset: Sanger_Terms
is_a: MP:0006387 ! abnormal T cell number
is_a: MP:0012762 ! abnormal alpha-beta T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T21:58:23Z

[Term]
id: MP:0012764
name: increased alpha-beta T cell number
def: "greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
subset: Sanger_Terms
is_a: MP:0005015 ! increased T cell number
is_a: MP:0012763 ! abnormal alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T21:58:23Z

[Term]
id: MP:0012765
name: decreased alpha-beta T cell number
def: "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
subset: Sanger_Terms
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0012763 ! abnormal alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T21:58:23Z

[Term]
id: MP:0012766
name: abnormal KLRG1-positive NK cell number
def: "deviation in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [https://orcid.org/0000-0003-4890-4685, PMID:19479342]
subset: Sanger_Terms
is_a: MP:0008043 ! abnormal NK cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:17:58Z

[Term]
id: MP:0012767
name: increased KLRG1-positive NK cell number
def: "increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [https://orcid.org/0000-0003-4890-4685, PMID:19479342]
subset: Sanger_Terms
is_a: MP:0008044 ! increased NK cell number
is_a: MP:0012766 ! abnormal KLRG1-positive NK cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:19:45Z

[Term]
id: MP:0012768
name: decreased KLRG1-positive NK cell number
def: "decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [https://orcid.org/0000-0003-4890-4685, PMID:19479342]
subset: Sanger_Terms
synonym: "reduced KLRG1-positive NK cell number" EXACT []
is_a: MP:0008045 ! decreased NK cell number
is_a: MP:0012766 ! abnormal KLRG1-positive NK cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:19:45Z

[Term]
id: MP:0012769
name: abnormal CD4-positive, alpha-beta memory T cell number
def: "anomaly in the number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897]
is_a: MP:0008048 ! abnormal memory T cell number
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:34:14Z

[Term]
id: MP:0012770
name: abnormal effector memory CD4-positive, alpha-beta T cell number
def: "anomaly in the number of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905]
is_a: MP:0012769 ! abnormal CD4-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:37:45Z

[Term]
id: MP:0012771
name: abnormal central memory CD4-positive, alpha-beta T cell number
def: "anomaly in the number of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904]
is_a: MP:0012769 ! abnormal CD4-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T22:37:57Z

[Term]
id: MP:0012772
name: abnormal central memory CD8-positive, alpha-beta T cell number
def: "an anomaly in the number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [MP:0000907]
is_a: MP:0008048 ! abnormal memory T cell number
is_a: MP:0010846 ! abnormal central memory CD8 positive, alpha-beta T cell morphology
is_a: MP:0012774 ! abnormal CD8-positive, alpha-beta memory T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T23:01:51Z

[Term]
id: MP:0012773
name: abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "any anomaly in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
is_a: MP:0004972 ! abnormal regulatory T cell number
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
is_a: MP:0008397 ! abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-09T23:11:23Z

[Term]
id: MP:0012774
name: abnormal CD8-positive, alpha-beta memory T cell number
def: "an anomaly in the number of CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive; this cell type is also described as being CD25-negative, CD44-high, and CD122-high" [CL:0000909]
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number
is_a: MP:0010837 ! abnormal CD8-positive, alpha-beta memory T cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T11:18:25Z

[Term]
id: MP:0012775
name: abnormal brain weight
def: "anomaly in the average weight of the brain" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000771 ! abnormal brain size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T14:10:56Z

[Term]
id: MP:0012776
name: abnormal liver cholesterol level
def: "aberrant amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic cholesterol level" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0003947 ! abnormal cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T21:12:52Z

[Term]
id: MP:0012777
name: abnormal liver glycogen level
def: "abnormal concentration of a readily converted carbohydrate reserve in liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic glycogen level" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0005437 ! abnormal glycogen level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T21:12:52Z

[Term]
id: MP:0012778
name: abnormal liver triglyceride level
def: "aberrant concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal hepatic triglyceride level" EXACT []
is_a: MP:0000187 ! abnormal triglyceride level
is_a: MP:0000598 ! abnormal liver morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T21:12:52Z

[Term]
id: MP:0012779
name: abnormal brain cholesterol level
def: "aberrant amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0003947 ! abnormal cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T21:42:38Z

[Term]
id: MP:0012780
name: abnormal phospholipid transfer protein activity
def: "altered ability of phospholipid transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL)" [http://en.wikipedia.org/wiki/Phospholipid_transfer_protein, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T22:01:02Z

[Term]
id: MP:0012781
name: increased phospholipid transfer protein activity
def: "greater ability of phospholipd transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL)" [http://en.wikipedia.org/wiki/Phospholipid_transfer_protein, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012780 ! abnormal phospholipid transfer protein activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T22:02:41Z

[Term]
id: MP:0012782
name: decreased phospholipid transfer protein activity
def: "reduction in the ability of phospholipd transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL)" [http://en.wikipedia.org/wiki/Phospholipid_transfer_protein, https://orcid.org/0000-0001-5208-3432]
synonym: "reduced phospholipid transfer protein activity" EXACT []
is_a: MP:0012780 ! abnormal phospholipid transfer protein activity
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T22:02:41Z

[Term]
id: MP:0012783
name: abnormal extensor digitorum longus weight
def: "anomaly in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004246 ! abnormal extensor digitorum longus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-10T22:07:20Z

[Term]
id: MP:0012784
name: abnormal rhombomere 1 morphology
def: "any structural anomaly of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005499]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:29:54Z

[Term]
id: MP:0012785
name: decreased rhombomere 1 size
def: "reduced size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 1 size" EXACT []
is_a: MP:0012784 ! abnormal rhombomere 1 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:29:54Z

[Term]
id: MP:0012786
name: increased rhombomere 1 size
def: "increased size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 1" EXACT []
is_a: MP:0012784 ! abnormal rhombomere 1 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:29:54Z

[Term]
id: MP:0012787
name: absent rhombomere 1
def: "absence of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012784 ! abnormal rhombomere 1 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:29:54Z

[Term]
id: MP:0012788
name: abnormal rhombomere 2 morphology
def: "any structural anomaly of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005569]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:30:45Z

[Term]
id: MP:0012789
name: decreased rhombomere 2 size
def: "reduced size of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 2 size" EXACT []
is_a: MP:0012788 ! abnormal rhombomere 2 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:30:45Z

[Term]
id: MP:0012790
name: increased rhombomere 2 size
def: "increased size of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 2" EXACT []
is_a: MP:0012788 ! abnormal rhombomere 2 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:30:45Z

[Term]
id: MP:0012791
name: absent rhombomere 2
def: "absence of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012788 ! abnormal rhombomere 2 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:30:45Z

[Term]
id: MP:0012792
name: abnormal rhombomere 3 morphology
def: "any structural anomaly of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005507]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:31:50Z

[Term]
id: MP:0012793
name: decreased rhombomere 3 size
def: "reduced size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 3 size" EXACT []
is_a: MP:0012792 ! abnormal rhombomere 3 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:31:50Z

[Term]
id: MP:0012794
name: increased rhombomere 3 size
def: "increased size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 3" EXACT []
is_a: MP:0012792 ! abnormal rhombomere 3 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:31:50Z

[Term]
id: MP:0012795
name: absent rhombomere 3
def: "absence of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012792 ! abnormal rhombomere 3 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:31:50Z

[Term]
id: MP:0012796
name: abnormal rhombomere 4 morphology
def: "any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005511]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:32:30Z

[Term]
id: MP:0012797
name: decreased rhombomere 4 size
def: "reduced size of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 4 size" EXACT []
is_a: MP:0012796 ! abnormal rhombomere 4 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:32:30Z

[Term]
id: MP:0012798
name: increased rhombomere 4 size
def: "increased size of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 4" EXACT []
is_a: MP:0012796 ! abnormal rhombomere 4 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:32:30Z

[Term]
id: MP:0012799
name: absent rhombomere 4
def: "absence of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012796 ! abnormal rhombomere 4 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:32:30Z

[Term]
id: MP:0012800
name: abnormal rhombomere 5 morphology
def: "any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005515]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:05Z

[Term]
id: MP:0012801
name: decreased rhombomere 5 size
def: "reduced size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 5 size" EXACT []
is_a: MP:0012800 ! abnormal rhombomere 5 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:05Z

[Term]
id: MP:0012802
name: increased rhombomere 5 size
def: "increased size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 5" EXACT []
is_a: MP:0012800 ! abnormal rhombomere 5 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:05Z

[Term]
id: MP:0012803
name: absent rhombomere 5
def: "absence of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012800 ! abnormal rhombomere 5 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:05Z

[Term]
id: MP:0012804
name: abnormal rhombomere 6 morphology
def: "any structural anomaly of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005519]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:40Z

[Term]
id: MP:0012805
name: decreased rhombomere 6 size
def: "reduced size of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 6 size" EXACT []
is_a: MP:0012804 ! abnormal rhombomere 6 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:40Z

[Term]
id: MP:0012806
name: increased rhombomere 6 size
def: "increased size of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 6" EXACT []
is_a: MP:0012804 ! abnormal rhombomere 6 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:40Z

[Term]
id: MP:0012807
name: absent rhombomere 6
def: "absence of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012804 ! abnormal rhombomere 6 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:33:40Z

[Term]
id: MP:0012808
name: abnormal rhombomere 7 morphology
def: "any structural anomaly of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005523]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:34:33Z

[Term]
id: MP:0012809
name: decreased rhombomere 7 size
def: "reduced size of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 7 size" EXACT []
is_a: MP:0012808 ! abnormal rhombomere 7 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:34:33Z

[Term]
id: MP:0012810
name: increased rhombomere 7 size
def: "increased size of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 7" EXACT []
is_a: MP:0012808 ! abnormal rhombomere 7 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:34:33Z

[Term]
id: MP:0012811
name: absent rhombomere 7
def: "absence of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012808 ! abnormal rhombomere 7 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:34:33Z

[Term]
id: MP:0012812
name: abnormal rhombomere 8 morphology
def: "any structural anomaly of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-3691-0324, UBERON:0005527]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:35:10Z

[Term]
id: MP:0012813
name: decreased rhombomere 8 size
def: "reduced size of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced rhombomere 8 size" EXACT []
is_a: MP:0012812 ! abnormal rhombomere 8 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:35:10Z

[Term]
id: MP:0012814
name: increased rhombomere 8 size
def: "increased size of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged rhombomere 8" EXACT []
is_a: MP:0012812 ! abnormal rhombomere 8 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:35:10Z

[Term]
id: MP:0012815
name: absent rhombomere 8
def: "absence of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012812 ! abnormal rhombomere 8 morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:35:10Z

[Term]
id: MP:0012816
name: abnormal rhombomere boundary morphology
def: "any structural anomaly of the anatomical surface separating the rhombomere segments" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:36:17Z

[Term]
id: MP:0012817
name: rhombomere fusion
def: "the union of one or more rhombomeres into a single structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "fused rhombomeres" EXACT []
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:36:17Z

[Term]
id: MP:0012818
name: rhombomere transformation
def: "homeotic transformation of a specific rhombomere to adopt the fate of another" [https://orcid.org/0000-0003-3691-0324]
synonym: "transformed rhombomeres" EXACT []
is_a: MP:0000933 ! abnormal rhombomere morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-14T15:36:17Z

[Term]
id: MP:0013000
name: absent cerebral aqueduct
def: "absence of the channel in the mesencephalon that connects the third and fourth ventricles" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent aqueduct of midbrain" EXACT []
synonym: "absent aqueduct of Sylvius" EXACT []
synonym: "absent cerebral aqueduct of Sylvius" EXACT []
synonym: "absent mesencephalic duct" EXACT []
synonym: "absent mesencephalic vesicle" EXACT []
synonym: "cerebral aqueduct agenesis" EXACT []
synonym: "missing cerebral aqueduct" EXACT []
is_a: MP:0005537 ! abnormal cerebral aqueduct morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0013001
name: abnormal enteric neural crest cell morphology
def: "any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans)" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
synonym: "abnormal ENCC morphology" EXACT []
synonym: "abnormal ENCDC morphology" EXACT []
synonym: "abnormal enteric neural crest-derived cell morphology" EXACT []
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013002
name: decreased enteric neural crest cell number
def: "a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
synonym: "decreased ENCC number" EXACT []
synonym: "decreased ENCDC number" EXACT []
synonym: "decreased enteric neural crest-derived cell number" EXACT []
synonym: "reduced ENCC number" EXACT []
synonym: "reduced ENCDC number" EXACT []
synonym: "reduced enteric neural crest cell number" EXACT []
synonym: "reduced enteric neural crest-derived cell number" EXACT []
is_a: MP:0009843 ! decreased neural crest cell number
is_a: MP:0013001 ! abnormal enteric neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith

[Term]
id: MP:0013003
name: absent enteric neural crest cell
def: "absence or loss of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
synonym: "absent ENCCs" EXACT []
synonym: "absent ENCDCs" EXACT []
synonym: "absent enteric neural crest cells" EXACT []
synonym: "absent enteric neural crest-derived cells" EXACT []
is_a: MP:0013002 ! decreased enteric neural crest cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013004
name: abnormal enteric neural crest cell proliferation
def: "any anomaly in the ability of the enteric neural crest cells to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
synonym: "abnormal ENCC proliferation" EXACT []
synonym: "abnormal ENCDC proliferation" EXACT []
synonym: "abnormal enteric neural crest-derived cell proliferation" EXACT []
is_a: MP:0009842 ! abnormal neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013005
name: decreased enteric neural crest cell proliferation
def: "reduced ability of the enteric neural crest cells to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ENCC proliferation" EXACT []
synonym: "decreased ENCDC proliferation" EXACT []
synonym: "decreased enteric neural crest-derived cell proliferation" EXACT []
synonym: "reduced ENCC proliferation" EXACT []
synonym: "reduced ENCDC proliferation" EXACT []
synonym: "reduced enteric neural crest cell proliferation" EXACT []
synonym: "reduced enteric neural crest-derived cell proliferation" EXACT []
is_a: MP:0012741 ! decreased neural crest cell proliferation
is_a: MP:0013004 ! abnormal enteric neural crest cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013006
name: abnormal enteric neural crest cell migration
def: "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
synonym: "abnormal ENCC migration" EXACT []
synonym: "abnormal ENCDC migration" EXACT []
synonym: "abnormal enteric neural crest-derived cell migration" EXACT []
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013007
name: abnormal vagal neural crest cell migration
def: "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7; at approximately E8.5-9 in the mouse, vagal NCCs invade the anterior foregut and migrate in a rostral to caudal direction to colonize the entire foregut, midgut, cecum, and hindgut and give rise to the majority of the enteric nervous system (ENS); colonization is complete by E15.5 (or after 7 weeks gestation in humans); the most caudal vagal NCCs, emanating from a region overlapping with the most anterior trunk NCCs, make a small contribution to the ENS of the esophagus and the anterior stomach" [https://orcid.org/0000-0002-6490-7723, PMID:17514199]
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013008
name: abnormal sacral neural crest cell migration
def: "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the sacral region of the neural tube (sacral neural crest), caudal to somite 28, and migrate caudo-rostrally to contribute to a small fraction of enteric neurons and glia in the distal midgut and hindgut; in the mouse, sacral NCCs emigrate from the neural tube at E9.5, accumulate bilateral to the hindgut to form prospective pelvic ganglia at E11.5, and from there enter the distal hindgut through its ventrolateral side at E13.5; they then migrate along nerve fibers extending from the pelvic ganglia toward the proximal hindgut, intermingling with rostrocaudally migrating vagal NCCs to differentiate into neurons and glia" [http://www.ncbi.nlm.nih.gov/books/NBK10065/, https://orcid.org/0000-0002-6490-7723, PMID:17514199]
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013009
name: increased vagal neural crest cell apoptosis
def: "increased number of vagal neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723, PMID:22016183]
synonym: "increased post-otic NCC apoptosis" EXACT []
synonym: "increased post-otic neural crest cell apoptosis" EXACT []
synonym: "increased vagal NCC apoptosis" EXACT []
is_a: MP:0012744 ! increased neural crest cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013010
name: abnormal vagal neural crest cell morphology
def: "any structural anomaly of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7 (the cranial part of the vagal level overlaps the caudal part of the cranial level, as the first few somites form adjacent to the rhombencephalon, not the spinal cord); the vagal neural crest produces the neurons and glial cells of the enteric nervous system (ENS); like NCCs from other axial levels, the vagal neural crest contributes to the neurons and glial cells of the peripheral nervous system and the melanocytes that populate the skin" [https://orcid.org/0000-0002-6490-7723, PMMID:22016183]
synonym: "abnormal post-otic NCC morphology" EXACT []
synonym: "abnormal post-otic neural crest cell morphology" EXACT []
synonym: "abnormal vagal NCC morphology" EXACT []
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013011
name: absent vagal neural crest cells
def: "absence of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7" [https://orcid.org/0000-0002-6490-7723, PMID:22016183]
synonym: "absent post-otic neural crest cells" EXACT []
is_a: MP:0009843 ! decreased neural crest cell number
is_a: MP:0013010 ! abnormal vagal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013012
name: abnormal trunk neural crest cell migration
def: "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the trunk neural crest which lies between the vagal and sacral neural crest; there are two major pathways taken by the migrating trunk NCCs: (1) one group of cells fated to become melanocytes (the melanin-forming pigment cells) migrates dorsolaterally into the ectoderm towards the ventral midline and colonizes the skin and hair follicles; (2) a second group of cells migrates ventrolaterally through the anterior portion of each sclerotome; the cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons, whereas those that continue more ventrally form the sympathetic ganglia, chromaffin cells of the adrenal medulla, Schwann (precursor) cells, and the nerve clusters surrounding the aorta" [http://www.ncbi.nlm.nih.gov/books/NBK10065/, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal body NCC migration" EXACT []
synonym: "abnormal body neural crest cell migration" EXACT []
synonym: "abnormal truncal NCC migration" EXACT []
synonym: "abnormal truncal neural crest cell migration" EXACT []
synonym: "abnormal trunk NCC migration" EXACT []
is_a: MP:0002950 ! abnormal neural crest cell migration
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013013
name: abnormal trunk neural crest cell morphology
def: "any structural anomaly of the neural crest cells (NCCs) that arise from the trunk neural crest (located between the vagal and sacral neural crest) and differentiate into a variety of cell types, including melanocytes, the neurons and glia of the dorsal root and sympathetic ganglia, Schwann (precursor) cells, chromaffin cells of the adrenal medulla, and the nerve clusters surrounding the aorta" [http://www.ncbi.nlm.nih.gov/books/NBK10065/, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal body NCC morphology" EXACT []
synonym: "abnormal body neural crest cell morphology" EXACT []
synonym: "abnormal truncal NCC morphology" EXACT []
synonym: "abnormal truncal neural crest cell morphology" EXACT []
synonym: "abnormal trunk NCC morphology" EXACT []
is_a: MP:0009845 ! abnormal neural crest cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013014
name: increased trunk neural crest cell apoptosis
def: "increased number of trunk neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased body NCC apoptosis" EXACT []
synonym: "increased body neural crest cell apoptosis" EXACT []
synonym: "increased truncal NCC apoptosis" EXACT []
synonym: "increased truncal neural crest cell apoptosis" EXACT []
synonym: "increased trunk NCC apoptosis" EXACT []
is_a: MP:0012744 ! increased neural crest cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013015
name: obsolete abnormal CD4-positive, alpha beta T cell number
def: "aberrant number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers" [CL:0000624]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determed to be identical to previously entered term MP:0008073.  The term label of MP:0008073 has been changed to reflect this.
synonym: "abnormal CD4-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008073
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013016
name: obsolete increased CD4-positive, alpha beta T cell number
def: "reduced number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers" [CL:0000624]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determined to be identical to previously entered term MP:0008074.  The term label of MP:0008074 has been changed to reflect this.
synonym: "increased CD4-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008074
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013017
name: obsolete decreased CD4-positive, alpha beta T cell number
def: "increased number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers" [CL:0000624]
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determed to be identical to previously entered term MP:0008075.  The term label of MP:0008075 has been changed to reflect this.
synonym: "decreased CD4-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced CD4-positive, alpha-beta T cell number" EXACT []
synonym: "reduced CD4-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008075
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013018
name: obsolete abnormal CD8-positive alpha beta T cell number
def: "aberrant number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers" []
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determed to be identical to previously entered term MP:0008077.  The term label of MP:0008077 has been changed to reflect this.
synonym: "abnormal CD8-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008077
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013019
name: obsolete increased CD8-positive, alpha beta T cell number
def: "greater number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers" []
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determed to be identical to previously entered term MP:0008078.  The term label of MP:0008078 has been changed to reflect this.
synonym: "increased CD8-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008078
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013020
name: obsolete decreased CD8-positive, alpha beta T cell number
def: "reduced number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers" []
comment: Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625).  Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624).  T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.\nThis term was determed to be identical to previously entered term MP:0008079.  The term label of MP:0008079 has been changed to reflect this.
synonym: "decreased CD8-positive, alpha beta T lymphocyte number" EXACT []
synonym: "decreased CD8-positive, alpha-beta T lymphocyte number" EXACT []
synonym: "reduced CD8-positive, alpha-beta T lymphocyte number" EXACT []
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0008079
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013021
name: abnormal Ly6C high monocyte number
def: "deviation in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0012441 ! abnormal monocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013022
name: increased Ly6C high monocyte number
def: "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0000220 ! increased monocyte cell number
is_a: MP:0013021 ! abnormal Ly6C high monocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013023
name: decreased Ly6C high monocyte number
def: "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0000223 ! decreased monocyte cell number
is_a: MP:0013021 ! abnormal Ly6C high monocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013024
name: abnormal Ly6C low monocyte number
def: "deviation in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0012441 ! abnormal monocyte cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013025
name: increased Ly6C low monocyte number
def: "increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0000220 ! increased monocyte cell number
is_a: MP:0013024 ! abnormal Ly6C low monocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013026
name: decreased Ly6C low monocyte number
def: "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0000223 ! decreased monocyte cell number
is_a: MP:0013024 ! abnormal Ly6C low monocyte number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013027
name: wounding
def: "an injury resulting in damage that tears, cuts or breaks tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0005376 ! homeostasis/metabolism phenotype

[Term]
id: MP:0013028
name: open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013029
name: open avulsion
def: "a wound where the tissue has been torn from its attachment.; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013030
name: open incision
def: "a wound created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013031
name: open laceration
def: "an irregular wound created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013032
name: open puncture
def: "a penetrating wound cause by pointed object (e.g. bites)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013033
name: closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013034
name: entire body wounds
def: "injuries resulting in damage that tears or breaks tissue occurring across the whole body" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013035
name: entire body open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring across the whole body" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013036
name: entire body open avulsion
def: "a wound or wounds where the tissue has been torn from its attachment, occurring across the whole body; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013037
name: entire body open incision
def: "a wound or wounds created by a sharp object, occurring across the whole body; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013038
name: entire body open laceration
def: "an irregular wound or wounds created by tearing of tissue, occurring across the whole body; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013039
name: entire body open puncture
def: "a penetrating wound or wounds occurring across the whole body caused by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013040
name: entire body closed contusion
def: "damage of the skin and/or underlying strutures occurring across the whole body without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013034 ! entire body wounds
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013041
name: thorax wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the thorax" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013042
name: thorax open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the thorax" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013043
name: thorax open avulsion
def: "a wound on the thorax where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013044
name: thorax open incision
def: "a wound on the thorax created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013045
name: thorax open laceration
def: "an irregular wound on the thorax created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013046
name: thorax open puncture
def: "a penetrating wound on the thorax cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013047
name: thorax closed contusion
def: "damage of the skin and/or underlying strutures of the thorax without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013041 ! thorax wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-06T00:00:00Z

[Term]
id: MP:0013048
name: abdomen wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the abdomen" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding

[Term]
id: MP:0013049
name: abdomen open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the abdomen" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013050
name: abdomen open avulsion
def: "a wound occurring on the abdomen where the tissue has been torn from its attachment" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013051
name: abdomen open incision
def: "a wound occurring on the abdomen created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013052
name: abdomen open laceration
def: "an irregular wound occurring on the abdomen created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013053
name: abdomen open puncture
def: "a penetrating wound occurring on the abdomen cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013054
name: abdomen closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the abdomen" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013048 ! abdomen wound

[Term]
id: MP:0013055
name: genital wound
def: "injuries resulting in damage that tears or breaks tissue occurring on genital tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013056
name: genital open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin occurring on genital tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013057
name: genital open avulsion
def: "a wound occurring on genital tissue where the tissue has been torn from its attachment" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013058
name: genital open incision
def: "a wound occurring on genital tissue created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013059
name: genital open laceration
def: "an irregular wound occurring on genital tissue created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013060
name: genital open puncture
def: "a penetrating wound occurring on genital tissue cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013061
name: genital closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush) occurring on genital tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013055 ! genital wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013062
name: teat wound
def: "injuries resulting in damage that tears or breaks tissue occurring on teat tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0006078 ! abnormal nipple morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013063
name: teat open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin occurring on teat tissue" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013064
name: teat open avulsion
def: "a wound occurring on teat tissue where the tissue has been torn from its attachment" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013065
name: teat open incision
def: "a wound occurring on teat tissue created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013066
name: teat open laceration
def: "an irregular wound occurring on teat tissue created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013067
name: teat open puncture
def: "a penetrating wound occurring on teat tissue cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013068
name: teat closed contusion
def: "damage of the skin and/or underlying strutures occurring on teat tissue without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013062 ! teat wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013069
name: limb wound
def: "injuries resulting in damage that tears or breaks tissue occurring on limbs" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002109 ! abnormal limb morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013070
name: limb open abrasion
def: "damage to the skin occurring on limbs consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013071
name: limb open avulsion
def: "a wound occurring on limbs where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013072
name: limb open incision
def: "a wound occurring on limbs created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013073
name: limb open laceration
def: "an irregular wound occurring on limbs created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013074
name: limb open puncture
def: "a penetrating wound occurring on limbs cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013075
name: limb closed contusion
def: "damage of the skin and/or underlying strutures occurring on limbs, without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013069 ! limb wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013076
name: autopod wound
def: "injuries resulting in damage that tears or breaks tissue occurring on autopods" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw wound" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013077
name: autopod open abrasion
def: "damage to the skin occurring on autopods consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw open abrasion" NARROW []
is_a: MP:0013028 ! open abrasion
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013078
name: autopod open avulsion
def: "a wound occurring on autopods where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw open avulsion" NARROW []
is_a: MP:0013029 ! open avulsion
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013079
name: autopod open incision
def: "a wound occurring on autopods created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw open incision" NARROW []
is_a: MP:0013030 ! open incision
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013080
name: autopod open laceration
def: "an irregular wound occurring on autopods created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw open laceration" NARROW []
is_a: MP:0013031 ! open laceration
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013081
name: autopod open puncture
def: "a penetrating wound occurring on autopods cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw open puncture" NARROW []
is_a: MP:0013032 ! open puncture
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013082
name: autopod closed contusion
def: "damage of the skin and/or underlying strutures occurring on autopods, without breaking the skin (e.g. bruising, crush)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "paw closed contusion" NARROW []
is_a: MP:0013033 ! closed contusion
is_a: MP:0013076 ! autopod wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-07T00:00:00Z

[Term]
id: MP:0013083
name: tail wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the tail" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002111 ! abnormal tail morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013084
name: tail open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the tail" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013085
name: tail open avulsion
def: "a wound occurring on the tail where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013086
name: tail open incision
def: "a wound occurring on the tail created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013087
name: tail open laceration
def: "an irregular wound occurring on the tail created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013088
name: tail open puncture
def: "a penetrating wound occurring on the tail cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013089
name: tail closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the tail" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013083 ! tail wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013090
name: head or neck wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the head and/or neck" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013091
name: head or neck open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the head and/or neck" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013092
name: head or neck open avulsion
def: "a wound where the tissue has been torn from its attachment occurring on the head and/or neck" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013093
name: head or neck open incision
def: "a wound occurring on the head and/or neck created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013094
name: head or neck open laceration
def: "an irregular wound occurring on the head and/or neck created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013095
name: head or neck open puncture
def: "a penetrating wound occurring on the head and/or neck cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013096
name: head or neck closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the head and/or neck" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013090 ! head or neck wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013097
name: ear wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the ears" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002177 ! abnormal outer ear morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013098
name: ear open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the ears" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013099
name: ear open avulsion
def: "a wound occurring on the ears where the tissue has been torn from its attachment" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013100
name: ear open incision
def: "a wound occurring on the ears created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013101
name: ear open laceration
def: "an irregular wound occurring on the ears created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013102
name: ear open puncture
def: "a penetrating wound occurring on the ears cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013103
name: ear closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the ears" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013097 ! ear wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013104
name: nose wound
def: "injuries resulting in damage that tears or breaks tissue occurring on the nose" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0013027 ! wounding
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013105
name: nose open abrasion
def: "damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the nose" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013028 ! open abrasion
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013106
name: nose open avulsion
def: "a wound occurring on the nose where the tissue has been torn from its attachment" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013029 ! open avulsion
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013107
name: nose open incision
def: "a wound occurring on the nose created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013030 ! open incision
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013108
name: nose open laceration
def: "an irregular wound occurring on the nose created by tearing of tissue; damage to both superficial and underlying tissue is variable" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013031 ! open laceration
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013109
name: nose open puncture
def: "a penetrating wound occurring on the nose cause by pointed object (e.g. bite)" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013032 ! open puncture
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013110
name: nose closed contusion
def: "damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the nose" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013033 ! closed contusion
is_a: MP:0013104 ! nose wound
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013111
name: greasy abdomen coat
def: "fur on the abdomen is oily in appearance or texture" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0003849 ! greasy coat

[Term]
id: MP:0013112
name: greasy thorax coat
def: "fur on the thorax is oily in appearance or texture" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0003849 ! greasy coat
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013113
name: greasy tail
def: "tail is oily in appearance or texture" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0002111 ! abnormal tail morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013114
name: greasy head/neck
def: "head and/or neck is oily in appearance or texture" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0000432 ! abnormal head morphology
is_a: MP:0012719 ! abnormal neck morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013115
name: focal hair loss in abdominal region
def: "focal absence of hair on the abdomen, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000418 ! focal hair loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013116
name: focal hair loss in head/neck region
def: "focal absence of hair in the head and/or neck region, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000418 ! focal hair loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013117
name: focal hair loss in thorax region
def: "focal absence of hair on the thorax, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0000418 ! focal hair loss
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013118
name: swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0010678 ! abnormal skin adnexa morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013119
name: abdomen swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the abdominal region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013120
name: urogenital swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the urogenital region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013121
name: testicular swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin of the testicles" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013122
name: tail swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin of the tail" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013123
name: head/neck swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the head/neck region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013124
name: mouth swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) in the mouth region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013125
name: thorax swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the thorax region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013126
name: teat swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the teat region" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0013118 ! swellings
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013127
name: epistaxis
def: "hemorrhage from the nose, usually apparent when the blood drains out through the nostrils" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "nasal haemorrhage" EXACT []
synonym: "nasal hemorrhage" EXACT []
synonym: "nose bleeding" EXACT []
synonym: "nosebleed" EXACT []
is_a: MP:0001914 ! hemorrhage
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013128
name: nipple hemorrhage
def: "bleeding from the nipples" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "nipple haemorrhage" EXACT []
is_a: MP:0001881 ! abnormal mammary gland physiology
is_a: MP:0001914 ! hemorrhage
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013129
name: abnormal tooth color
def: "anomaly in the color and shading of the teeth, which normally present in shades of white" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "abnormal tooth colour" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013130
name: abnormal gum color
def: "anomaly in the color and shading of the gums, which normally present in shades of red" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "abnormal gum colour" EXACT []
is_a: MP:0020459 ! abnormal gum morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013131
name: pale lips
def: "lips lack normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0003769 ! abnormal lip morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013132
name: pale gums
def: "gums lack normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0013130 ! abnormal gum color

[Term]
id: MP:0013133
name: pale limbs
def: "limbs lack normal ruddy coloration; often occurs with a bloodless or reduced vasculature condition" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0002109 ! abnormal limb morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013134
name: poor circulation in autopods
def: "insufficient movement of blood throughout the autopods, resulting in a pale appearance and cool to touch" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "poor circulation in paws" NARROW []
is_a: MP:0001633 ! poor circulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013135
name: poor circulation in tail
def: "insufficient movement of blood throughout the tail, resulting in a pale appearance and cool to touch" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001633 ! poor circulation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013136
name: genital discharge
def: "the emission or secretion of unusual fluid from the genitals" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001919 ! abnormal reproductive system physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013137
name: nipple discharge
def: "the emission or secretion of unusual fluid from the nipples" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001881 ! abnormal mammary gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013138
name: thin body
def: "lean or slender in form" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001265 ! decreased body size
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013139
name: moribund
def: "in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0010769 ! abnormal survival
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013140
name: excessive vocalization
def: "producing sound from the vocal organs more frequently or more loudly than expected" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001529 ! abnormal vocalization
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013141
name: sexually aggressive behavior
def: "subjects exhibit greater than the normal level of domineering, assertive posturing and/or hostile physical action toward partners while mating" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "sexually aggressive behaviour" EXACT []
is_a: MP:0002566 ! abnormal sexual interaction
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013142
name: anal soreness
def: "tenderness or irritation of the anal area, usually evident by redness of the area" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0005034 ! abnormal anus morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013143
name: penis inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the penis" [https://orcid.org/0000-0002-4467-7270, https://orcid.org/0000-0002-6490-7723]
subset: IMPC
synonym: "inflamed penes" EXACT []
synonym: "inflamed penis" EXACT []
synonym: "inflamed penises" EXACT []
synonym: "penile inflammation" EXACT []
synonym: "penitis" EXACT []
synonym: "phallitis" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0011762 ! renal/urinary system inflammation
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013144
name: obsolete greasy skin
def: "OBSOLETE. skin is oily in appearance or texture" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
is_obsolete: true
replaced_by: MP:0001197
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013145
name: eye discharge
def: "the emission or secretion of unusual fluid from the eyes" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0005253 ! abnormal eye physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013146
name: eye lesions
def: "lesions on or around the eyes" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0002092 ! abnormal eye morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013147
name: limb paralysis
def: "severe or complete loss of power of voluntary movement in muscles of the limbs through injury or disease of muscles or of the nerve supply" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0000753 ! paralysis
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013148
name: mastitis
def: "inflammation of the teats or mammary glands" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "breast inflammation" EXACT []
synonym: "mammary gland inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0001881 ! abnormal mammary gland physiology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013149
name: macrodactyly
def: "significant increase in the length and girth dimensions of most or all of a digit compared to the expected size" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
synonym: "megadactyly" EXACT []
is_a: MP:0002110 ! abnormal digit morphology
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013150
name: head/neck piloerection
def: "anomaly in the involuntary bristling of hairs on the head and/or neck that occurs when an organism is cold or experiences strong emotions such as fear or awe" [https://orcid.org/0000-0002-4467-7270]
subset: IMPC
is_a: MP:0001492 ! abnormal pilomotor reflex
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-08T00:00:00Z

[Term]
id: MP:0013151
name: abnormal incidence of induced tumors
def: "aberration from the normal frequency of tumor incidence induced by a carcinogen, mutagen or virus" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal incidence of induced tumours" EXACT []
is_a: MP:0002019 ! abnormal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith

[Term]
id: MP:0013152
name: abnormal organ/body region tumor incidence
def: "anomaly in the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal organ/body region tumour incidence" EXACT []
is_a: MP:0002019 ! abnormal tumor incidence

[Term]
id: MP:0013153
name: abnormal KLRG1+ CD8 alpha-beta T cell number
def: "anomaly in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013154
name: increased KLRG1+ CD8 alpha-beta T cell number
def: "increase in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0008078 ! increased CD8-positive, alpha-beta T cell number
is_a: MP:0013153 ! abnormal KLRG1+ CD8 alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013155
name: decreased KLRG1+ CD8 alpha-beta T cell number
def: "decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "reduced KLRG1+ CD8 alpha beta T cell number" EXACT []
is_a: MP:0008079 ! decreased CD8-positive, alpha-beta T cell number
is_a: MP:0013153 ! abnormal KLRG1+ CD8 alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013156
name: abnormal KLRG1+ CD4 alpha-beta T cell number
def: "anomaly in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0008073 ! abnormal CD4-positive, alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013157
name: increased KLRG1+ CD4 alpha-beta T cell number
def: "increase in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0008074 ! increased CD4-positive, alpha-beta T cell number
is_a: MP:0013156 ! abnormal KLRG1+ CD4 alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013158
name: decreased KLRG1+ CD4 alpha-beta T cell number
def: "reduction in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
synonym: "reduced KLRG1+ CD4 alpha beta T cell number" EXACT []
is_a: MP:0008075 ! decreased CD4-positive, alpha-beta T cell number
is_a: MP:0013156 ! abnormal KLRG1+ CD4 alpha-beta T cell number
property_value: terms:contributor https://orcid.org/0000-0003-3691-0324
created_by: csmith
creation_date: 2014-05-19T00:00:00Z

[Term]
id: MP:0013159
name: Purkinje cell axonal dystrophy
def: "Purkinje cell-autonomous progressive dystrophy leading to cell death, manifested by axonal swellings and degeneration of nerve terminals, while Purkinje cell dendrites remain largely unaffected" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000876 ! Purkinje cell degeneration
is_a: MP:0003225 ! axonal dystrophy

[Term]
id: MP:0013160
name: impaired muscle regeneration
def: "decrease in the renewal, repair, and/or regrowth of muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased muscle regeneration" EXACT []
synonym: "reduced muscle regeneration" EXACT []
is_a: MP:0000750 ! abnormal muscle regeneration

[Term]
id: MP:0013161
name: enhanced muscle regeneration
def: "increase in the renewal, repair, and/or regrowth of muscle tissue following injury or disease" [https://orcid.org/0000-0003-3691-0324]
synonym: "improved muscle regeneration" EXACT []
synonym: "increased muscle regeneration" EXACT []
is_a: MP:0000750 ! abnormal muscle regeneration

[Term]
id: MP:0013162
name: abnormal thyroid gland isthmus morphology
def: "any structural anomaly of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland and usually covers the second and the third tracheal rings; the thyroid isthmus is variable in presence and size, can change shape and size, and can encompass a cranially extending pyramid lobe (lobus pyramidalis or processus pyramidalis), remnant of the thyroglossal duct" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal isthmus glandulae thyroideae morphology" EXACT []
synonym: "abnormal thyroid isthmus morphology" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0013163
name: absent thyroid gland isthmus
def: "absence of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent isthmus glandulae thyroideae" EXACT []
synonym: "absent thyroid isthmus" EXACT []
synonym: "agenesis of isthmus glandulae thyroideae" EXACT []
synonym: "thyroid gland isthmus agenesis" EXACT []
synonym: "thyroid isthmus agenesis" EXACT []
is_a: MP:0013162 ! abnormal thyroid gland isthmus morphology

[Term]
id: MP:0013164
name: abnormal forelimb bud morphology
def: "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal anterior limb bud morphology" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology

[Term]
id: MP:0013165
name: absent forelimb buds
def: "absence or loss of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent anterior limb buds" EXACT []
is_a: MP:0004573 ! absent limb buds
is_a: MP:0013164 ! abnormal forelimb bud morphology

[Term]
id: MP:0013166
name: small forelimb buds
def: "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased anterior limb bud size" EXACT []
synonym: "decreased forelimb bud size" EXACT []
synonym: "reduced anterior limb bud size" EXACT []
synonym: "reduced forelimb bud size" EXACT []
synonym: "small anterior limb buds" EXACT []
is_a: MP:0004575 ! small limb buds
is_a: MP:0013164 ! abnormal forelimb bud morphology

[Term]
id: MP:0013167
name: abnormal hindlimb bud morphology
def: "any structural anomaly of the limb bud that develops into a hindlimb (usually the leg or back limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hind limb bud morphology" EXACT []
synonym: "abnormal posterior limb bud morphology" EXACT []
is_a: MP:0005650 ! abnormal limb bud morphology

[Term]
id: MP:0013168
name: absent hindlimb buds
def: "absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of hind limb buds" EXACT []
synonym: "absent posterior limb buds" EXACT []
is_a: MP:0004573 ! absent limb buds
is_a: MP:0013167 ! abnormal hindlimb bud morphology

[Term]
id: MP:0013169
name: small hindlimb buds
def: "reduced size of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased hind limb bud size" EXACT []
synonym: "decreased hindlimb bud size" EXACT []
synonym: "decreased posterior limb bud size" EXACT []
synonym: "reduced hind limb bud size" EXACT []
synonym: "reduced hindlimb bud size" EXACT []
synonym: "reduced posterior limb bud size" EXACT []
synonym: "small hind limb buds" EXACT []
synonym: "small posterior limb buds" EXACT []
is_a: MP:0004575 ! small limb buds
is_a: MP:0013167 ! abnormal hindlimb bud morphology

[Term]
id: MP:0013170
name: eye swellings
def: "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) on or around the eyes" [MGI:Ahmed_Retha]
is_a: MP:0002092 ! abnormal eye morphology
is_a: MP:0013118 ! swellings

[Term]
id: MP:0013171
name: ear hemorrhage
def: "bleeding through the ear canal" [MGI:Ahmed_Retha]
synonym: "ear haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0003878 ! abnormal ear physiology

[Term]
id: MP:0013172
name: obsolete miscarriage
def: "OBSOLETE. accidental or natural termination of a clear pregnancy at a stage where the fetus is incapable of surviving independently of the mother" [https://orcid.org/0000-0002-4467-7270]
synonym: "spontaneous abortion" EXACT []
is_obsolete: true
replaced_by: MP:0031434

[Term]
id: MP:0013173
name: trigeminal ganglion degeneration
def: "retrogressive pathological change of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [https://orcid.org/0000-0002-6490-7723]
synonym: "cranial ganglion V degeneration" EXACT []
synonym: "Gasserian ganglion degeneration" EXACT []
synonym: "semi-lunar ganglion degeneration" EXACT []
synonym: "semilunar ganglion degeneration" EXACT []
synonym: "trigeminal ganglia degeneration" EXACT []
synonym: "trigeminal ganglion of trigeminal (V) nerve degeneration" EXACT []
is_a: MP:0001092 ! abnormal trigeminal ganglion morphology

[Term]
id: MP:0013174
name: pharynx stenosis
def: "abnormal narrowing or constriction of the passage between the mouth and the posterior nares and the larynx and esophagus" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow pharynx" EXACT []
synonym: "pharyngeal stenosis" EXACT []
is_a: MP:0002234 ! abnormal pharynx morphology

[Term]
id: MP:0013175
name: bifurcated tail
def: "the appearance of an abnormal division in the flexible elongated appendage located at the caudal end of the torso in many species" [https://orcid.org/0000-0002-6490-7723]
synonym: "split tail" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0013176
name: abnormal tail position or orientation
def: "tail is displaced from the normal location and/or does not orient in a typical pattern" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0013177
name: abnormal tail tip morphology
def: "any structural anomaly of the distal end of the tail" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0013178
name: tail necrosis
def: "morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "necrotic tail" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0013179
name: wavy tail
def: "undulations or a sinusoidal shape of the tail" [https://orcid.org/0000-0002-6490-7723]
synonym: "s-shaped tail" EXACT []
synonym: "undulated tail" EXACT []
is_a: MP:0002111 ! abnormal tail morphology

[Term]
id: MP:0013180
name: truncated tail bud
def: "shortened tail bud that terminates in a blunt end (instead of a tapered end)" [https://orcid.org/0000-0002-6490-7723]
synonym: "short tail bud" EXACT []
is_a: MP:0002861 ! abnormal tail bud morphology

[Term]
id: MP:0013181
name: absent placenta
def: "absence of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing placenta" EXACT []
synonym: "placenta agenesis" EXACT []
synonym: "placental agenesis" EXACT []
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0013182
name: increased spinal cord apoptosis
def: "increase in the number of cells of the spinal cord undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0013183
name: absent trigeminal ganglion
def: "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cranial ganglion V" EXACT []
synonym: "absent Gasserian ganglion" EXACT []
synonym: "absent semi-lunar ganglion" EXACT []
synonym: "absent semilunar ganglion" EXACT []
synonym: "absent trigeminal ganglia" EXACT []
synonym: "absent trigeminal ganglion of trigeminal (V) nerve" EXACT []
synonym: "trigeminal ganglion agenesis" EXACT []
is_a: MP:0001092 ! abnormal trigeminal ganglion morphology

[Term]
id: MP:0013184
name: hemorrhagic ascites
def: "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "bloody ascites" EXACT []
synonym: "haemorrhagic ascites" EXACT []
is_a: MP:0005324 ! ascites

[Term]
id: MP:0013185
name: absent anterior definitive endoderm
def: "absence of the mesendoderm which first migrates from the node and which gives rise to the gut" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ADE" EXACT []
is_a: MP:0008926 ! abnormal anterior definitive endoderm morphology

[Term]
id: MP:0013186
name: abnormal basilar artery morphology
def: "any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004950 ! abnormal brain vasculature morphology

[Term]
id: MP:0013187
name: dilated basilar artery
def: "stretched or widened aperture of the luminal space of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "basilar artery dilation" EXACT []
synonym: "dilated basilar arteries" EXACT []
is_a: MP:0004938 ! dilated vasculature
is_a: MP:0013186 ! abnormal basilar artery morphology

[Term]
id: MP:0013188
name: abnormal gastrocnemius weight
def: "any anomaly of the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [MPD:Molly]
is_a: MP:0003082 ! abnormal gastrocnemius morphology

[Term]
id: MP:0013189
name: abnormal exploration in a new environment
def: "anomaly in the amount of time spent investigating new location" [MPD:Molly]
is_a: MP:0001413 ! abnormal response to new environment

[Term]
id: MP:0013190
name: abnormal sebaceous gland number
def: "any anomaly in the number of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0013191
name: increased sebaceous gland number
def: "greater than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013190 ! abnormal sebaceous gland number

[Term]
id: MP:0013192
name: decreased sebaceous gland number
def: "fewer than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced sebaceous gland number" EXACT []
is_a: MP:0013190 ! abnormal sebaceous gland number

[Term]
id: MP:0013193
name: sebaceous gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the sebaceous gland, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic sebaceous gland" EXACT []
is_a: MP:0012725 ! small sebaceous gland

[Term]
id: MP:0013194
name: absent anterior primitive streak
def: "absence of the anterior region of the vertebrate primitive streak which normally gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012739 ! abnormal anterior primitive streak morphology

[Term]
id: MP:0013195
name: abnormal anterior primitive streak formation
def: "anomaly in the establishment of the anterior region of the vertebrate primitive streak which normally gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012739 ! abnormal anterior primitive streak morphology

[Term]
id: MP:0013196
name: abnormal posterior primitive streak formation
def: "anomaly in the establishment of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012740 ! abnormal posterior primitive streak morphology

[Term]
id: MP:0013197
name: decreased embryonic cilium number
def: "reduced number of the cilia of the mouse embryo found on the cells of the embryonic node" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased embryonic cilia number" EXACT []
synonym: "decreased motile primary cilia number" EXACT []
synonym: "decreased motile primary cilium number" EXACT []
synonym: "decreased nodal primary cilia number" EXACT []
synonym: "decreased nodal primary cilium number" EXACT []
synonym: "reduced embryonic cilia number" EXACT []
synonym: "reduced embryonic cilium number" EXACT []
synonym: "reduced motile primary cilia number" EXACT []
synonym: "reduced motile primary cilium number" EXACT []
synonym: "reduced nodal primary cilia number" EXACT []
synonym: "reduced nodal primary cilium number" EXACT []
is_a: MP:0004131 ! abnormal motile primary cilium morphology

[Term]
id: MP:0013198
name: absent head mesenchyme
def: "absence of the primordial embryonic connective tissue of the developing head, normally consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cephalic mesenchyme" EXACT []
synonym: "absent cranial mesenchyme" EXACT []
is_a: MP:0011260 ! abnormal head mesenchyme morphology

[Term]
id: MP:0013199
name: increased head mesenchyme apoptosis
def: "increase in the number of cells of the head mesenchyme undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cephalic mesenchyme apoptosis" EXACT []
synonym: "increased cranial mesenchyme apoptosis" EXACT []
is_a: MP:0011260 ! abnormal head mesenchyme morphology
is_a: MP:0013504 ! increased embryonic tissue cell apoptosis

[Term]
id: MP:0013200
name: head mesenchyme hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the head mesenchyme, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "cephalic mesenchyme hypoplasia" EXACT []
synonym: "cranial mesenchyme hypoplasia" EXACT []
synonym: "decreased cephalic mesenchyme cellularity" EXACT []
synonym: "decreased cranial mesenchyme cellularity" EXACT []
synonym: "decreased head mesenchyme cellularity" EXACT []
synonym: "hypoplastic cephalic mesenchyme" EXACT []
synonym: "hypoplastic cranial mesenchyme" EXACT []
synonym: "hypoplastic head mesenchyme" EXACT []
is_a: MP:0011260 ! abnormal head mesenchyme morphology

[Term]
id: MP:0013201
name: head mesenchyme hyperplasia
def: "increase in the number of normal cells in normal arrangement in the head mesenchyme, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "cephalic mesenchyme hyperplasia" EXACT []
synonym: "cranial mesenchyme hyperplasia" EXACT []
synonym: "hyperplastic cephalic mesenchyme" EXACT []
synonym: "hyperplastic cranial mesenchyme" EXACT []
synonym: "hyperplastic head mesenchyme" EXACT []
synonym: "increased cephalic mesenchyme cellularity" EXACT []
synonym: "increased cranial mesenchyme cellularity" EXACT []
synonym: "increased head mesenchyme cellularity" EXACT []
is_a: MP:0011260 ! abnormal head mesenchyme morphology

[Term]
id: MP:0013202
name: abnormal cilium morphology
def: "any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole" [GO:0005929]
synonym: "abnormal eukaryotic flagellum morphology" EXACT []
synonym: "abnormal flagellum morphology" EXACT []
is_a: MP:0000358 ! abnormal cell morphology

[Term]
id: MP:0013203
name: abnormal primary cilium morphology
def: "any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]
is_a: MP:0013202 ! abnormal cilium morphology

[Term]
id: MP:0013204
name: obsolete abnormal motile primary cilium morphology
def: "any structural anomaly of a primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors; motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization" [GO:0031512]
comment: This term has been determined to be identical to MP:0004131
synonym: "abnormal motile primary cilia morphology" EXACT []
synonym: "abnormal nodal cilia morphology" EXACT []
synonym: "abnormal nodal cilium morphology" EXACT []
is_obsolete: true
replaced_by: MP:0004131

[Term]
id: MP:0013205
name: abnormal nonmotile primary cilium morphology
def: "any structural anomaly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors; nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules" [GO:0031513]
synonym: "abnormal immotile primary cilium morphology" EXACT []
synonym: "abnormal nonmotile primary cilia morphology" EXACT []
synonym: "abnormal sensory cilium morphology" EXACT []
is_a: MP:0013203 ! abnormal primary cilium morphology

[Term]
id: MP:0013206
name: abnormal motile cilium morphology
def: "any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles" [GO:0031514]
synonym: "abnormal microtubule-based flagellum morphology" EXACT []
synonym: "abnormal motile cilia morphology" EXACT []
synonym: "abnormal motile secondary cilium morphology" EXACT []
is_a: MP:0013202 ! abnormal cilium morphology

[Term]
id: MP:0013207
name: absent endoderm
def: "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent definitive endoderm" EXACT []
synonym: "absent entoderm" EXACT []
is_a: MP:0014140 ! abnormal endoderm morphology

[Term]
id: MP:0013208
name: abnormal cilium physiology
def: "any functional anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole" [GO:0005929]
synonym: "abnormal eukaryotic flagellum physiology" EXACT []
synonym: "abnormal flagellum physiology" EXACT []
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0013209
name: abnormal motile cilium physiology
def: "any functional anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles" [GO:0031514]
synonym: "abnormal microtubule-based flagellum physiology" EXACT []
synonym: "abnormal motile cilia physiology" EXACT []
synonym: "abnormal motile secondary cilium physiology" EXACT []
is_a: MP:0013208 ! abnormal cilium physiology

[Term]
id: MP:0013210
name: abnormal primary cilium physiology
def: "any functional anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]
is_a: MP:0013208 ! abnormal cilium physiology

[Term]
id: MP:0013211
name: abnormal nonmotile primary cilium physiology
def: "any functional anomaly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors; nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules" [GO:0031513]
synonym: "abnormal immotile primary cilium physiology" EXACT []
synonym: "abnormal nonmotile primary cilia physiology" EXACT []
synonym: "abnormal sensory cilium physiology" EXACT []
is_a: MP:0013210 ! abnormal primary cilium physiology

[Term]
id: MP:0013212
name: obsolete abnormal motile primary cilium physiology
def: "any functional anomaly of a primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors; motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization" [GO:0031512]
comment: This term has been determined to be identical to MP:0008933.
synonym: "abnormal motile primary cilia physiology" EXACT []
synonym: "abnormal nodal cilia physiology" EXACT []
synonym: "abnormal nodal cilium physiology" EXACT []
is_obsolete: true
replaced_by: MP:0008933

[Term]
id: MP:0013213
name: abnormal embryonic neuroepithelium primary cilium morphology
def: "any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning" [PMID:23351466]
synonym: "abnormal embryonic neural ectoderm cilium morphology" EXACT []
synonym: "abnormal embryonic neuroectoderm cilium morphology" EXACT []
synonym: "abnormal neural tube cilia" EXACT []
synonym: "abnormal neural tube cilium morphology" EXACT []
is_a: MP:0004261 ! abnormal embryonic neuroepithelium morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology

[Term]
id: MP:0013214
name: decreased embryonic neuroepithelium primary cilium number
def: "reduced number of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning" [PMID:23351466]
synonym: "decreased embryonic neural ectoderm cilium number" EXACT []
synonym: "decreased embryonic neuroectoderm cilium number" EXACT []
synonym: "decreased neural tube cilium number" EXACT []
is_a: MP:0013213 ! abnormal embryonic neuroepithelium primary cilium morphology

[Term]
id: MP:0013215
name: abnormal haptoglobin level
def: "anomaly in the amount of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0013216
name: absent ectoderm
def: "absence of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of ectoderm" EXACT []
synonym: "failure of ectoderm formation" EXACT []
is_a: MP:0014139 ! abnormal ectoderm morphology

[Term]
id: MP:0013217
name: abnormal posterior definitive endoderm morphology
def: "any structural anomaly of the posterior region of the definitive endoderm which evolves into the midgut and hindgut, which will eventually differentiate into the large and small intestine" [PMID:0080555950]
is_a: MP:0014140 ! abnormal endoderm morphology

[Term]
id: MP:0013218
name: abnormal substantia nigra pars reticulata morphology
def: "any structural anomaly of the anterior (ventral) part of grey matter of the substantia nigra which contains smaller and loosely packed cells than the pars compacta, only some of which contain a small amount of pigment; the cells of pars reticulata bear a strong structural and functional resemblance to the inner segment of the globus pallidus; many cells in this region use GABA as a neurotransmitter" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pars reticularis substantiae nigrae morphology" EXACT []
synonym: "abnormal reticular part of substantia nigra" EXACT []
synonym: "abnormal SNPR morphology" EXACT []
synonym: "abnormal substantia nigra pars reticularis morphology" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology

[Term]
id: MP:0013219
name: abnormal substantia nigra pars compacta morphology
def: "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal compact part of substantia nigra" EXACT []
synonym: "abnormal pars compacta substantiae nigrae morphology" EXACT []
synonym: "abnormal SNPC morphology" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology

[Term]
id: MP:0013220
name: increased pancreas apoptosis
def: "increase in the number of cells of the pancreas undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased pancreatic apoptosis" EXACT []
is_a: MP:0002693 ! abnormal pancreas physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0013221
name: pancreatic acinar-to-ductal metaplasia
def: "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [https://orcid.org/0000-0002-6490-7723]
synonym: "pancreatic ADM" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0013222
name: abnormal first pharyngeal pouch morphology
def: "any structural anomaly of the first endodermal branchial pouch located between the first and second branchial arches; in mammals, the first pouch elongates to form a diverticulum known as the tubotympanic recess; the distal portion of this recess expands to reach the first branchial groove and form the middle ear cavity (aka tympanic cavity) and mastoid antrum; its proximal part remains tubular and forms the auditory tube (aka Eustachian or pharyngotympanic tube), which forms a communication between the nasopharynx and tympanic cavity" [http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-50-the-pharyngeal-clefts-and-pouches, https://www.inkling.com/read/before-we-are-born-moore-persaud-torchia-8th/chapter-10/pharyngeal-pouches]
synonym: "abnormal 1st branchial pouch morphology" EXACT []
synonym: "abnormal 1st pharyngeal pouch morphology" EXACT []
synonym: "abnormal first branchial pouch morphology" EXACT []
is_a: MP:0006031 ! abnormal pharyngeal pouch morphology

[Term]
id: MP:0013223
name: abnormal second pharyngeal pouch morphology
def: "any structural anomaly of the second branchial pouch located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils; in rodents, the ventral portion of the second pouch appears to degenerate whereas the remaining part is incorporated into the lateral border of the pharynx; it appears that rodents no longer require tonsils as their function is carried out by the NALT (Nose/Nasal-Associated Lymphoid Tissue) system in the upper respiratory tract" [PMID:20144910]
synonym: "abnormal 2nd branchial pouch morphology" EXACT []
synonym: "abnormal 2nd pharyngeal pouch morphology" EXACT []
synonym: "abnormal second branchial pouch morphology" EXACT []
is_a: MP:0006031 ! abnormal pharyngeal pouch morphology

[Term]
id: MP:0013224
name: absent second pharyngeal pouch
def: "absence of the second branchial pouch, normally located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils" [PMID:20144910]
synonym: "absent 2nd branchial pouch" EXACT []
synonym: "absent 2nd pharyngeal pouch" EXACT []
synonym: "absent second branchial pouch" EXACT []
is_a: MP:0013223 ! abnormal second pharyngeal pouch morphology

[Term]
id: MP:0013225
name: abnormal third pharyngeal pouch morphology
def: "any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910]
synonym: "abnormal 3rd branchial pouch morphology" EXACT []
synonym: "abnormal 3rd pharyngeal pouch morphology" EXACT []
synonym: "abnormal third branchial pouch morphology" EXACT []
is_a: MP:0006031 ! abnormal pharyngeal pouch morphology

[Term]
id: MP:0013226
name: absent third pharyngeal pouch
def: "absence of the third endodermal branchial pouch, normally located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910]
synonym: "absent 3rd branchial pouch" EXACT []
synonym: "absent 3rd pharyngeal pouch" EXACT []
synonym: "absent third branchial pouch" EXACT []
is_a: MP:0013225 ! abnormal third pharyngeal pouch morphology

[Term]
id: MP:0013227
name: small brain ventricles
def: "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased brain ventricle size" EXACT []
synonym: "decreased cerebral ventricle size" EXACT []
synonym: "reduced brain ventricle size" EXACT []
synonym: "reduced cerebral ventricle size" EXACT []
synonym: "small cerebral ventricles" EXACT []
is_a: MP:0013229 ! abnormal brain ventricle size

[Term]
id: MP:0013228
name: brain ventricle stenosis
def: "abnormal narrowing or constriction of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "cerebral ventricle stenosis" EXACT []
synonym: "ventricular stenosis" RELATED []
is_a: MP:0000822 ! abnormal brain ventricle morphology

[Term]
id: MP:0013229
name: abnormal brain ventricle size
def: "any anomaly in the size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cerebral ventricle size" EXACT []
is_a: MP:0000822 ! abnormal brain ventricle morphology

[Term]
id: MP:0013230
name: abnormal cervical sinus morphology
def: "any structural anomaly of the temporary triangular depression found in the nuchal region caudal to the second (hyoid) branchial arch, and containing the succeeding branchial arches and grooves; the sinus is overgrown by the second branchial arch and is ultimately obliterated during extension of the cervical flexure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cervical sinus of His morphology" EXACT []
synonym: "abnormal sinus cervicalis morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0013231
name: abnormal pharyngeal groove morphology
def: "any structural anomaly of the ectodermally lined depressions (grooves or clefts) that separate the branchial arches externally on each side; only the first of the four pairs of branchial grooves persists in the adult to form the epithelium of the external auditory meatus and part of the tympanic membrane; the second, third, and fourth grooves are overlapped by the development of branchial arch 2 and form a slit-like depression known as the cervical sinus which is ultimately obliterated by the fusion of its walls during extension of the cervical flexure" [http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-50-the-pharyngeal-clefts-and-pouches, PMID:20144910]
synonym: "abnormal branchial cleft morphology" EXACT []
synonym: "abnormal branchial groove morphology" EXACT []
synonym: "abnormal pharyngeal cleft morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0013232
name: abnormal pharyngeal membrane morphology
def: "any structural anomaly of any of the four membranes that separate the branchial pouches from the corresponding branchial grooves in a developing embryo; each membrane is initially composed of an inner layer formed by the endodermal lining of a branchial pouch and an outer layer formed by the ectodermal lining of the branchial groove; later, these two layers become separated by a thin layer of mesoderm; only the first branchial membrane contributes to the formation of an adult structure, i.e. the tympanic membrane (aka eardrum); the second, third, and fourth membranes are obliterated" [http://www.slideshare.net/ElsevierIndia/vishram-singh-chapter10, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal branchial arch membrane morphology" EXACT []
synonym: "abnormal branchial membrane morphology" EXACT []
synonym: "abnormal pharyngeal membrane morphology" RELATED []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0013233
name: ectopic thyroid gland
def: "a thyroid gland located outside of its normal position anterior to the laryngeal cartilages; usually due to abnormal migration of the thyroid diverticulum down from the foramen cecum at the posterior aspect of the tongue to its permanent pre-tracheal location; ectopic thyroid tissue is frequently found along the course of the thyroglossal duct or laterally in the neck, as well as in distant places such as the mediastinum and the subdiaphragmatic organs; the most common ectopic location is near its embryological origin at the foramen caecum, resulting in a lingual thyroid" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic thyroid" EXACT []
synonym: "thyroid ectopy" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0013234
name: abnormal tongue foramen cecum morphology
def: "any structural anomaly of the median pit on the dorsum of the posterior part of the tongue, from which the limbs of a V-shaped furrow run forward and outward; the foramen cecum is the point of attachment of the thyroglossal duct and is formed during the embryological descent of the thyroid gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal blind foramen of the tongue moprhology" EXACT []
synonym: "abnormal cecal foramen of the tongue morphology" EXACT []
synonym: "abnormal ductus lingualis morphology" EXACT []
synonym: "abnormal foramen cecum linguae morphology" EXACT []
synonym: "abnormal Morgagni foramen1 morphology" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0013235
name: abnormal thyroglossal duct morphology
def: "any structural anomaly of the embryological anatomical structure that forms an open connection between the initial area of development of the thyroid gland and its final position; it is located exactly midline, between the anterior 2/3rds and posterior 1/3rd of the tongue; this duct normally atrophies and closes off as the foramen cecum before birth" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ductus thyroglossus morphology" EXACT []
synonym: "abnormal thyrolingual duct morphology" EXACT []
is_a: MP:0003421 ! abnormal thyroid gland development

[Term]
id: MP:0013236
name: ovary degeneration
def: "a retrogressive impairment of function or destruction of one or both ovaries" [https://orcid.org/0000-0002-6490-7723]
synonym: "ovarian degeneration" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013237
name: abnormal skeletal muscle regeneration
def: "anomaly in the renewal, repair, and/or regrowth of skeletal muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000750 ! abnormal muscle regeneration

[Term]
id: MP:0013238
name: abnormal cardiac muscle regeneration
def: "anomaly in the renewal, repair, and/or regrowth of cardiac muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal heart muscle regeneration" EXACT []
is_a: MP:0000750 ! abnormal muscle regeneration

[Term]
id: MP:0013239
name: impaired skeletal muscle regeneration
def: "decrease in the renewal, repair, and/or regrowth of skeletal muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased skeletal muscle regeneration" EXACT []
synonym: "reduced skeletal muscle regeneration" EXACT []
is_a: MP:0013160 ! impaired muscle regeneration
is_a: MP:0013237 ! abnormal skeletal muscle regeneration

[Term]
id: MP:0013240
name: impaired cardiac muscle regeneration
def: "decrease in the renewal, repair, and/or regrowth of cardiac muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiac muscle regeneration" EXACT []
synonym: "decreased heart muscle regeneration" EXACT []
synonym: "reduced cardiac muscle regeneration" EXACT []
synonym: "reduced heart muscle regeneration" EXACT []
is_a: MP:0013160 ! impaired muscle regeneration
is_a: MP:0013238 ! abnormal cardiac muscle regeneration

[Term]
id: MP:0013241
name: embryo tissue necrosis
def: "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "embryonic tissue necrosis" EXACT []
synonym: "necrotic embryo" EXACT []
synonym: "necrotic embryo tissue" EXACT []
synonym: "necrotic embryonic tissue" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0013242
name: abnormal amino acid metabolism
def: "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0013243
name: abnormal carbohydrate metabolism
def: "any anomaly in the chemical reactions and pathways involving a carbohydrate, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0013244
name: abnormal vitamin metabolism
def: "any anomaly in the chemical reactions and pathways involving a vitamin, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0013274 ! abnormal vitamin or vitamin cofactor metabolism

[Term]
id: MP:0013245
name: abnormal lipid metabolism
def: "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0013246
name: abnormal peptide metabolism
def: "any anomaly in the chemical reactions and pathways involving a peptide, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0013247
name: placenta necrosis
def: "morphological changes resulting from pathological death of placenta tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic placenta" EXACT []
synonym: "placental necrosis" EXACT []
is_a: MP:0001711 ! abnormal placenta morphology

[Term]
id: MP:0013248
name: placenta junctional zone necrosis
def: "morphological changes resulting from pathological death of placenta junctional zone tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic placenta junctional zone" EXACT []
synonym: "necrotic placental junctional zone" EXACT []
synonym: "placental junctional zone necrosis" EXACT []
is_a: MP:0008957 ! abnormal placenta junctional zone morphology
is_a: MP:0013247 ! placenta necrosis

[Term]
id: MP:0013249
name: adipose tissue necrosis
def: "morphological changes resulting from pathological death of adipose tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "necrotic adipose tissue" EXACT []
is_a: MP:0000003 ! abnormal adipose tissue morphology

[Term]
id: MP:0013250
name: abnormal dental pulp morphology
def: "any structural anomaly of the soft tissue within the pulp cavity located in the center of a tooth, comprised of living connective tissue containing blood vessels, nerves and lymphatics, and a layer of odontoblasts at the periphery, which participate in dentin repair" [https://orcid.org/0000-0003-3691-0324, ISBN:068340007X]
synonym: "abnormal dentinal pulp morphology" EXACT []
synonym: "abnormal tooth pulp morphology" EXACT []
is_a: MP:0002819 ! abnormal dental pulp cavity morphology

[Term]
id: MP:0013251
name: dental pulp necrosis
def: "morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "dentinal pulp necrosis" EXACT []
synonym: "necrotic dental pulp" EXACT []
synonym: "necrotic tooth pulp" EXACT []
synonym: "tooth pulp necrosis" EXACT []
is_a: MP:0013250 ! abnormal dental pulp morphology

[Term]
id: MP:0013252
name: head mesenchyme necrosis
def: "morphological changes resulting from pathological death of head mesenchyme tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "cephalic mesenchyme necrosis" EXACT []
synonym: "cranial mesenchyme necrosis" RELATED []
synonym: "necrotic cephalic mesenchyme" EXACT []
synonym: "necrotic cranial mesenchyme" RELATED []
is_a: MP:0011260 ! abnormal head mesenchyme morphology
is_a: MP:0013241 ! embryo tissue necrosis

[Term]
id: MP:0013253
name: outer ear necrosis
def: "morphological changes resulting from pathological death of outer ear tissue; usually due to irreversible damage" [https://orcid.org/0000-0003-3691-0324]
synonym: "external ear necrosis" EXACT []
synonym: "necrotic external ear" EXACT []
synonym: "necrotic external ears" EXACT []
synonym: "necrotic outer ear" EXACT []
synonym: "necrotic outer ears" EXACT []
synonym: "necrotic pinna" EXACT []
synonym: "necrotic pinnae" EXACT []
synonym: "pinna necrosis" EXACT []
synonym: "pinnae necrosis" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0013254
name: abnormal angiotensin I-converting enzyme activity
def: "altered activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin" [RGD:cur]
synonym: "abnormal ACE activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0013255
name: abnormal circulating thrombin level
def: "anomaly in the blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005416 ! abnormal circulating protein level

[Term]
id: MP:0013256
name: increased circulating thrombin level
def: "increased blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0013255 ! abnormal circulating thrombin level
is_a: MP:0014501 ! increased circulating protein level

[Term]
id: MP:0013257
name: decreased circulating thrombin level
def: "reduction in the blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0013255 ! abnormal circulating thrombin level
is_a: MP:0014502 ! decreased circulating protein level

[Term]
id: MP:0013258
name: abnormal extracellular matrix morphology
def: "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell" [GO:0031012]
is_a: MP:0005384 ! cellular phenotype

[Term]
id: MP:0013259
name: abnormal dendritic cell apoptosis
def: "change in the timing or the number of dendritic cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002376 ! abnormal dendritic cell physiology

[Term]
id: MP:0013260
name: decreased dendritic cell apoptosis
def: "reduction in the timing or the number of dendritic cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0013259 ! abnormal dendritic cell apoptosis

[Term]
id: MP:0013261
name: absent epiglottis
def: "missing the most superior of the laryngeal cartilages, which normally is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MIG:anna]
synonym: "epiglottis aplasia" EXACT []
is_a: MP:0010371 ! abnormal epiglottis morphology

[Term]
id: MP:0013262
name: abnormal mouth floor morphology
def: "any structural morphology of the ventral area of the mouth; in organisms with a tongue, a small horseshoe-shaped region situated beneath the movable part of the tongue and above the muscular diaphragm formed by the mylohyoid muscles; a median fold of mucous membrane, the lingual frenulum, connects the inferior surface of the tongue to the floor of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal floor of the oral cavity" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology

[Term]
id: MP:0013263
name: abnormal tongue frenulum morphology
def: "any structural anomaly of the small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal frenulum linguae morphology" EXACT []
synonym: "abnormal lingual frenulum morphology" EXACT []
synonym: "abnormal tongue frenum morphology" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
is_a: MP:0003745 ! abnormal oral mucosa morphology

[Term]
id: MP:0013264
name: tongue ankylosis
def: "partial or complete fusion or adherence of the tongue to the floor of the mouth, resulting in varying degrees of restricted tongue mobility; partial ankyloglossia (aka tongue-tie) is caused by a lingual frenulum that is abnormally short or is attached too close to the tip of the tongue; in complete ankyloglossia the tongue is tethered to the floor of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "ankyloglossia" EXACT []
synonym: "ankylosis of the tongue" EXACT []
synonym: "lingual ankylosis" EXACT []
synonym: "tongue-tie" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0013265
name: abnormal fourth pharyngeal pouch morphology
def: "any structural anomaly of the fourth endodermal branchial pouch located between the fourth and sixth branchial arches (a fifth arch never establishes itself in amniotes); in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland (the parathyroid glands derived from the third pouches descend with the thymus and are carried to a more inferior position than the parathyroid glands that are derived from the fourth pouches); the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland" [https://orcid.org/0000-0002-6490-7723, PMID:20144910]
synonym: "abnormal 4th branchial pouch morphology" EXACT []
synonym: "abnormal 4th pharyngeal pouch morphology" EXACT []
synonym: "abnormal fourth branchial pouch morphology" EXACT []
is_a: MP:0006031 ! abnormal pharyngeal pouch morphology

[Term]
id: MP:0013266
name: absent fourth pharynegal pouch
def: "absence of the fourth endodermal branchial pouch, normally located between the fourth and sixth branchial arches (a fifth arch never establishes itself in amniotes); in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland; the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland" [https://orcid.org/0000-0002-6490-7723, PMID:20144910]
synonym: "absent 4th branchial pouch" EXACT []
synonym: "absent 4th pharyngeal pouch" EXACT []
synonym: "absent fourth branchial pouch" EXACT []
is_a: MP:0013265 ! abnormal fourth pharyngeal pouch morphology

[Term]
id: MP:0013267
name: first pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the first pharyngeal arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "first branchial arch hypoplasia" EXACT []
synonym: "hypoplastic first pharyngeal arch" EXACT []
is_a: MP:0003873 ! pharyngeal arch hypoplasia
is_a: MP:0006341 ! small first pharyngeal arch

[Term]
id: MP:0013268
name: second pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the second pharyngeal arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic second pharyngeal arch" EXACT []
synonym: "second branchial arch hypoplasia" EXACT []
is_a: MP:0003873 ! pharyngeal arch hypoplasia
is_a: MP:0006344 ! small second pharyngeal arch

[Term]
id: MP:0013269
name: third pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the third pharyngeal arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic third pharyngeal arch" EXACT []
synonym: "third branchial arch hypoplasia" EXACT []
is_a: MP:0003873 ! pharyngeal arch hypoplasia
is_a: MP:0030133 ! small third pharyngeal arch

[Term]
id: MP:0013270
name: fourth pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the fourth pharyngeal arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "fourth branchial arch hypoplasia" EXACT []
synonym: "hypoplastic fourth pharyngeal arch" EXACT []
is_a: MP:0003873 ! pharyngeal arch hypoplasia
is_a: MP:0030134 ! small fourth pharyngeal arch

[Term]
id: MP:0013271
name: sixth pharyngeal arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the sixth pharyngeal arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic sixth pharyngeal arch" EXACT []
synonym: "sixth branchial arch hypoplasia" EXACT []
is_a: MP:0003873 ! pharyngeal arch hypoplasia
is_a: MP:0030135 ! small sixth pharyngeal arch

[Term]
id: MP:0013272
name: abnormal translation
def: "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]
synonym: "abnormal protein anabolism" EXACT []
synonym: "abnormal protein biosynthesis" EXACT []
synonym: "abnormal protein biosynthetic process" EXACT []
synonym: "abnormal protein formation" EXACT []
synonym: "abnormal protein synthesis" EXACT []
synonym: "abnormal protein translation" EXACT []
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0013273
name: abnormal translational elongation
def: "any anomaly in the process of successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis" [GO:0006414]
synonym: "abnormal protein synthesis elongation" EXACT []
synonym: "abnormal translation elongation" EXACT []
is_a: MP:0013272 ! abnormal translation

[Term]
id: MP:0013274
name: abnormal vitamin or vitamin cofactor metabolism
def: "any anomaly in the chemical reactions and pathways involving a vitamin or cofactor, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism

[Term]
id: MP:0013275
name: abnormal xenobiotic metabolism
def: "any anomaly in the chemical reactions and pathways involving a xenobiotic, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0008875 ! abnormal xenobiotic pharmacokinetics

[Term]
id: MP:0013276
name: absent alpha-beta T cells
def: "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation and express an alpha-beta T cell receptor complex" [CL:0000789]
is_a: MP:0012765 ! decreased alpha-beta T cell number

[Term]
id: MP:0013277
name: abnormal fasting circulating glucose level
def: "any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls" [https://orcid.org/0000-0002-2871-1985]
synonym: "abnormal fasted circulating glucose level" EXACT []
synonym: "abnormal fasting glucose level" BROAD []
is_a: MP:0000188 ! abnormal circulating glucose level

[Term]
id: MP:0013278
name: decreased fasting circulating glucose level
def: "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [https://orcid.org/0000-0002-2871-1985]
synonym: "decreased fasted circulating glucose level" EXACT []
synonym: "reduced fasted circulating glucose level" EXACT []
synonym: "reduced fasting circulating glucose level" EXACT []
is_a: MP:0005560 ! decreased circulating glucose level
is_a: MP:0013277 ! abnormal fasting circulating glucose level

[Term]
id: MP:0013279
name: increased fasting circulating glucose level
def: "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [https://orcid.org/0000-0002-2871-1985]
synonym: "increased fasted circulating glucose level" EXACT []
is_a: MP:0005559 ! increased circulating glucose level
is_a: MP:0013277 ! abnormal fasting circulating glucose level

[Term]
id: MP:0013280
name: abnormal cytotoxic T cell cytolysis
def: "altered ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005078 ! abnormal cytotoxic T cell physiology

[Term]
id: MP:0013281
name: increased cytotoxic T cell cytolysis
def: "increased ability of cytotoxic T cells to induce pathological breakdown of target cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0013280 ! abnormal cytotoxic T cell cytolysis

[Term]
id: MP:0013282
name: urinary bladder exstrophy
def: "a herniation of the urinary bladder through an anterior abdominal wall defect; refers to congenital absence of a portion of the lower anterior abdominal wall and the anterior urinary bladder wall, with eversion of the posterior bladder wall through the defect, an open pubic arch, and widely separated ischia connected by a fibrous band" [http://medical-dictionary.thefreedictionary.com/exstrophy+of+the+bladder, https://orcid.org/0000-0002-6490-7723, PMID:17079275]
synonym: "ectopia vesicae" EXACT []
synonym: "everted urinary bladder" EXACT []
synonym: "exposed urinary bladder" EXACT []
is_a: MP:0000538 ! abnormal urinary bladder morphology
is_a: MP:0000757 ! herniated abdominal wall

[Term]
id: MP:0013283
name: failure of ventral body wall closure
def: "failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality" [http://www.nbdpn.org/current/2008pdf/AMPresentations/EmbryologySadler.pdf, https://orcid.org/0000-0002-6490-7723, https://www.inkling.com/read/langmans-medical-embryology-thomas-sadler-12th/chapter-7/ch07-clinical-correlates-01]
synonym: "open ventral body wall" EXACT []
is_a: MP:0003384 ! abnormal ventral body wall morphology

[Term]
id: MP:0013284
name: abnormal renal glomerular filtration
def: "anomaly in the process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells" [GO:0003094]
is_a: MP:0013285 ! abnormal renal filtration

[Term]
id: MP:0013285
name: abnormal renal filtration
def: "any anomaly in the renal system process in which fluid circulating through the body is filtered through a barrier system" [GO:0097205]
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0013286
name: abnormal sperm capacitation
def: "anomaly in the series of morphological and molecular maturational processes undergone by spermatozoa in the female genital tract that enable them to penetrate and fertilize an egg" [GO:0048240]
is_a: MP:0001932 ! abnormal spermiogenesis

[Term]
id: MP:0013287
name: abnormal acrosome reaction
def: "anomaly in the discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte; the process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida" [GO:0007340]
is_a: MP:0004543 ! abnormal sperm physiology
is_a: MP:0005410 ! abnormal fertilization

[Term]
id: MP:0013288
name: premature acrosome reaction
def: "spontaneous initiation of the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs, occurring prior to encountering conditions that induce sperm capacitation" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013287 ! abnormal acrosome reaction

[Term]
id: MP:0013289
name: abnormal mitotic cytokinesis
def: "any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cytokinesis after mitosis" EXACT []
is_a: MP:0004046 ! abnormal mitosis

[Term]
id: MP:0013290
name: persistent ultimobranchial bodies
def: "partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells" [ISBN:032322153X]
synonym: "persistent corpus ultimopharyngeum" EXACT []
synonym: "persistent postbranchial bodies" EXACT []
synonym: "persistent telobranchial bodies" EXACT []
synonym: "persistent telopharyngeal bodies" EXACT []
synonym: "persistent ultimobranchial glands" EXACT []
synonym: "persistent ultimopharyngeal bodies" EXACT []
synonym: "persistent ultimopharyngeal glands" EXACT []
is_a: MP:0003955 ! abnormal ultimobranchial body morphology

[Term]
id: MP:0013291
name: ectopic pancreas
def: "presence of well-developed and normally organized pancreatic tissue lying outside its normal location without any anatomical and vascular continuity with the pancreas proper; although an ectopic pancreas can occur throughout the entire gastrointestinal tract, it is most commonly located in the stomach, duodenum, jejunum or Meckel's diverticulum" [https://orcid.org/0000-0002-6490-7723]
synonym: "aberrant pancreas" EXACT []
synonym: "accessory pancreas" EXACT []
synonym: "heterotopic pancreas" EXACT []
is_a: MP:0013861 ! abnormal pancreas topology

[Term]
id: MP:0013292
name: embryonic lethality prior to organogenesis
def: "death prior to the completion of embryo turning (Mus: E9-9.5)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
is_a: MP:0013293 ! embryonic lethality prior to tooth bud stage

[Term]
id: MP:0013293
name: embryonic lethality prior to tooth bud stage
def: "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
is_a: MP:0008762 ! embryonic lethality

[Term]
id: MP:0013294
name: prenatal lethality prior to heart atrial septation
def: "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [https://orcid.org/0000-0003-4606-0597]
subset: IMPC
is_a: MP:0002080 ! prenatal lethality

[Term]
id: MP:0013295
name: pancreas atrophy
def: "acquired size diminution of any portion of the pancreas, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic pancreas" EXACT []
synonym: "pancreatic atrophy" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0013296
name: abnormal susceptibility to induced colitis
def: "difference in the severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0001845 ! abnormal inflammatory response
is_a: MP:0010155 ! abnormal intestine physiology

[Term]
id: MP:0013297
name: abnormal susceptibility to colitis induced morbidity/mortality
def: "differences from the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-4890-4685]
synonym: "abnormal sensitivity to colitis induced morbidity/mortality" EXACT []
synonym: "altered susceptibility to colitis induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0013296 ! abnormal susceptibility to induced colitis

[Term]
id: MP:0013298
name: increased susceptibility to colitis induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-4890-4685]
synonym: "decreased resistance to colitis induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to colitis induced morbidity/mortality" EXACT []
is_a: MP:0008537 ! increased susceptibility to induced colitis
is_a: MP:0013297 ! abnormal susceptibility to colitis induced morbidity/mortality

[Term]
id: MP:0013299
name: decreased susceptibility to colitis induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [https://orcid.org/0000-0003-4890-4685]
synonym: "decreased sensitivity to colitis induced morbidity/mortality" EXACT []
synonym: "increased resistance to colitis induced morbidity/mortality" EXACT []
is_a: MP:0008539 ! decreased susceptibility to induced colitis
is_a: MP:0013297 ! abnormal susceptibility to colitis induced morbidity/mortality

[Term]
id: MP:0013300
name: abnormal submandibular gland physiology
def: "any functional anomaly of either of the large major salivary glands situated beneath the mandible" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013534 ! abnormal major salivary gland physiology

[Term]
id: MP:0013301
name: abnormal pancreas iron level
def: "anomaly in the amount of iron present in the pancreas tissue" [MGI:mlaw]
synonym: "abnormal pancreatic iron level" EXACT []
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0013302
name: increased pancreas iron level
def: "increase in the amount of iron present in the pancreas tissue" [MGI:mlaw]
synonym: "increased pancreatic iron level" EXACT []
is_a: MP:0013301 ! abnormal pancreas iron level
is_a: MP:0014541 ! increased iron level

[Term]
id: MP:0013303
name: decreased pancreas iron level
def: "reduction in the amount of iron present in the pancreas tissue" [MGI:mlaw]
synonym: "decreased pancreatic iron level" EXACT []
synonym: "reduced pancreas iron level" EXACT []
synonym: "reduced pancreatic iron level" EXACT []
is_a: MP:0013301 ! abnormal pancreas iron level
is_a: MP:0014542 ! decreased iron level

[Term]
id: MP:0013304
name: osteophytes
def: "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]
synonym: "bone spurs" EXACT []
is_a: MP:0003795 ! abnormal bone structure

[Term]
id: MP:0013305
name: isosthenuria
def: "inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired urine-concentrating ability" EXACT []
synonym: "urine concentrating defect" EXACT []
is_a: MP:0002136 ! abnormal kidney physiology

[Term]
id: MP:0013306
name: abnormal tela choroidea morphology
def: "any structural anomaly of that portion of the brain pia mater that covers the ependymal roof or, in the case of the lateral ventricle, medial wall of a cerebral ventricle; vascularized tela choroidea is choroid plexus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000822 ! abnormal brain ventricle morphology

[Term]
id: MP:0013307
name: increased adrenal gland weight
def: "greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012689 ! abnormal adrenal gland weight

[Term]
id: MP:0013308
name: decreased adrenal gland weight
def: "reduced average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced adrenal gland weight" EXACT []
is_a: MP:0012689 ! abnormal adrenal gland weight

[Term]
id: MP:0013309
name: adrenal gland cyst
def: "presence of one or more fluid-filled, usually benign growths, in the adrenal gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "adrenal cyst" EXACT []
synonym: "adrenal cysts" EXACT []
synonym: "adrenal gland cysts" EXACT []
synonym: "cystic adrenal gland" EXACT []
synonym: "cystic adrenal glands" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0013310
name: abnormal adrenal gland development
def: "aberrant formation or incomplete differentiation of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnoormal suprarenal capsule development" EXACT []
synonym: "abnormal adrenal body development" EXACT []
synonym: "abnormal adrenal capsule development" EXACT []
synonym: "abnormal adrenal development" EXACT []
synonym: "abnormal suprarenal body development" EXACT []
synonym: "abnormal suprarenal gland development" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013311
name: abnormal ovary capsule morphology
def: "any structural anomaly of the tough, fibrous capsule surrounding each ovary" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ovarian capsule morphology" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013312
name: absent ovary capsule
def: "missing the tough, fibrous capsule surrounding each ovary" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ovarian capsule" EXACT []
synonym: "unencapsulated ovary" EXACT []
is_a: MP:0013311 ! abnormal ovary capsule morphology

[Term]
id: MP:0013313
name: female preputial gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the female preputial gland, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "clitoral gland hypoplasia" EXACT []
synonym: "hypoplastic clitoral gland" EXACT []
synonym: "hypoplastic clitoral glands" EXACT []
synonym: "hypoplastic female preputial gland" EXACT []
synonym: "hypoplastic female preputial glands" EXACT []
is_a: MP:0011834 ! abnormal female preputial gland morphology
is_a: MP:0013193 ! sebaceous gland hypoplasia

[Term]
id: MP:0013314
name: abnormal eumelanosome morphology
def: "any structural anomaly of the elliptical-shaped pigment organelles that synthesize and store eumelanin (black/brown) pigment, which is deposited in smooth laminated fibrils of mature eumelanosomes" [ISBN:1444319663]
is_a: MP:0005075 ! abnormal melanosome morphology

[Term]
id: MP:0013315
name: abnormal pheomelanosome morphology
def: "any structural anomaly of the oval-shaped pigment organelles that synthesize and store pheomelanin (yellow) pigment, which is deposited in dense granular deposits within pheomelanosomes" [ISBN:1444319663]
synonym: "abnormal phaeomelanosome morphology" EXACT []
is_a: MP:0005075 ! abnormal melanosome morphology

[Term]
id: MP:0013316
name: abnormal pheomelanosome pheomelanin content
def: "anomaly in the amount or distribution of yellow pigment in the pheomelanosomes of melanocytes" [MGI:llw2]
synonym: "abnormal phaeomelanosome phaeomelanin content" EXACT []
is_a: MP:0013315 ! abnormal pheomelanosome morphology

[Term]
id: MP:0013317
name: abnormal seminal vesicle development
def: "aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus" [https://orcid.org/0000-0002-6490-7723]
comment: The seminal vesicles are present as branched organs in many mammals including mice and humans. However, the seminal vesicles are completely absent from some mammals including monotremes, marsupials, carnivores, and cetaceans. In addition, the seminal vesicles in some mammals such as the guinea-pig are present as unbranched tubular glands.
synonym: "abnormal gonecyst development" EXACT []
synonym: "abnormal seminal gland development" EXACT []
synonym: "gonecyst dysgenesis" EXACT []
synonym: "seminal gland dysgenesis" EXACT []
synonym: "seminal vesicle dysgenesis" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology
is_a: MP:0003936 ! abnormal reproductive system development
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013318
name: abnormal branching involved in seminal vesicle morphogenesis
def: "anomaly in the process in which the seminal vesicle is generated and organized in many mammals including mice and humans; in mice, the initial seminal vesicle buds form cane-shaped tubes off of the Wolffian ducts before birth; after birth, the initial tubes develop lateral branches that elongate and often undergo secondary branching morphogenesis; branching morphogenesis is largely complete by 2 weeks of age" [https://orcid.org/0000-0002-6490-7723, PMID:16916376]
comment: The seminal vesicles are present as branched organs in many mammals including mice and humans. However, the seminal vesicles are completely absent from some mammals including monotremes, marsupials, carnivores, and cetaceans. In addition, the seminal vesicles in some mammals such as the guinea-pig are present as unbranched tubular glands.
synonym: "abnormal branching involved in gonecyst morphogenesis" EXACT []
synonym: "abnormal branching involved in seminal gland morphogenesis" EXACT []
is_a: MP:0013317 ! abnormal seminal vesicle development

[Term]
id: MP:0013319
name: seminal vesicle atrophy
def: "acquired size diminution of the seminal vesicles, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic gonecysts" EXACT []
synonym: "atrophic seminal glands" EXACT []
synonym: "atrophic seminal vesicles" EXACT []
synonym: "gonecyst atrophy" EXACT []
synonym: "seminal gland atrophy" EXACT []
is_a: MP:0001157 ! small seminal vesicle

[Term]
id: MP:0013320
name: dilated seminal vesicle
def: "an expansion in the lumen volume of one or both of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system, as by stretching or distention" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated gonecyst" EXACT []
synonym: "dilated gonecysts" EXACT []
synonym: "dilated seminal gland" EXACT []
synonym: "dilated seminal glands" EXACT []
synonym: "dilated seminal vesicles" EXACT []
synonym: "distended gonecyst" EXACT []
synonym: "distended gonecysts" EXACT []
synonym: "distended seminal gland" EXACT []
synonym: "distended seminal glands" EXACT []
synonym: "distended seminal vesicle" EXACT []
synonym: "distended seminal vesicles" EXACT []
synonym: "gonecyst dilation" EXACT []
synonym: "seminal gland dilation" EXACT []
synonym: "seminal vesicle dilation" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0013321
name: squamous metaplasia of seminal vesicles
def: "a benign non-cancerous transformation of the pseudostratified columnar epithelium lining the seminal vesicle(s) into stratified squamous epithelium; may occur in response to irritation or inflammation and involve keratinization" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0013322
name: squamous metaplasia of prostate gland
def: "a benign non-cancerous transformation of the prostatic glandular epithelium into stratified squamous epithelium" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001158 ! abnormal prostate gland morphology

[Term]
id: MP:0013323
name: abnormal ampullary gland morphology
def: "any structural anomaly of the paired accessory, glandular, androgen-dependent outpouchings of the proximal ductus deferens, one on each side, that produce and secrete lipids and glycogen, components of the seminal fluid; they open into the ampullae at the level of the colliculus seminalis, are lined by simple columnar epithelium with large, oval nuclei, and may be distinguished from those of the prostate as they are surrounded by a characteristic, dense, fibromuscular stroma; the epithelium forms longitudinal folds and the glands contain homogeneous, dense, eosinophilic secretions with characteristic holes that impart a Swiss cheese-like appearance" [https://orcid.org/0000-0002-6490-7723, https://www.inkling.com/read/treuting-comparative-anatomy-histology-1st/chapter-18/accessory-sex-glands]
comment: There is no known human counterpart to the ampullary glands of the mouse.
is_a: MP:0002769 ! abnormal vas deferens morphology
is_a: MP:0013330 ! abnormal male accessory sex gland morphology

[Term]
id: MP:0013324
name: abnormal female reproductive gland morphology
def: "any structural anomaly of any sex gland that is part of the female reproductive system" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000653 ! abnormal sex gland morphology

[Term]
id: MP:0013325
name: abnormal male reproductive gland morphology
def: "any structural anomaly of any sex gland that is part of the male reproductive system" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000653 ! abnormal sex gland morphology

[Term]
id: MP:0013326
name: abnormal female reproductive gland physiology
def: "any functional anomaly of any sex gland that is part of the female reproductive system" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005647 ! abnormal sex gland physiology

[Term]
id: MP:0013327
name: abnormal male reproductive gland physiology
def: "any functional anomaly of any sex gland that is part of the male reproductive system" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005647 ! abnormal sex gland physiology

[Term]
id: MP:0013328
name: visceromegaly
def: "abnormal enlargement of the internal organs in the abdomen, including liver, spleen, stomach, kidneys, or pancreas" [https://orcid.org/0000-0002-6490-7723, ISBN:9780803609945]
synonym: "enlarged viscera" EXACT []
synonym: "splanchnomegaly" EXACT []
is_a: MP:0031094 ! organomegaly

[Term]
id: MP:0013329
name: abnormal preputial gland morphology
def: "any structural anomaly of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000647 ! abnormal sebaceous gland morphology
is_a: MP:0000653 ! abnormal sex gland morphology

[Term]
id: MP:0013330
name: abnormal male accessory sex gland morphology
def: "any structural anomaly of any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and seminal vesicles of the male" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013325 ! abnormal male reproductive gland morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0013331
name: abnormal lacrimal gland development
def: "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [https://orcid.org/0000-0002-6490-7723, PMID:22745308]
is_a: MP:0001346 ! abnormal lacrimal gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013332
name: peliosis
def: "presence of multiple cyst-like blood-filled lakes or cavities that lack endothelial linings within parenchymatous organs, typically found in the liver, spleen, bone marrow and lymph nodes; also described in other organs such as lungs, kidneys, parathyroids and pancreas" [https://orcid.org/0000-0002-6490-7723, PMID:15734106]
is_a: MP:0002127 ! abnormal cardiovascular system morphology

[Term]
id: MP:0013333
name: pituitary gland peliosis
def: "presence of cyst-like blood-filled lakes or cavities (extravasated erythrocytes not contained in capillaries) within the pituitary gland; commonly found in hyperplastic and adenomatous pituitary glands" [https://orcid.org/0000-0002-6490-7723, PMID:15734106, PMID:19089655]
synonym: "pituitary peliosis" EXACT []
synonym: "pituitary peliotic cavities" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology
is_a: MP:0013332 ! peliosis

[Term]
id: MP:0013334
name: adenohypophysis peliosis
def: "presence of cyst-like blood-filled lakes or cavities (extravasated erythrocytes not contained in capillaries) within the anterior lobe of the pituitary gland" [https://orcid.org/0000-0002-6490-7723, PMID:15734106]
synonym: "adenophysis peliosis" EXACT []
synonym: "anterior pituitary peliotic cavities" EXACT []
synonym: "peliosis of the anterior pituitary lobe" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology
is_a: MP:0013333 ! pituitary gland peliosis

[Term]
id: MP:0013335
name: hepatic peliosis
def: "presence of cyst-like blood-filled lakes or cavities that lack endothelial linings in the liver parenchyma" [https://orcid.org/0000-0002-6490-7723, PMID:15734106]
synonym: "hepatic peliotic cavities" EXACT []
synonym: "liver peliosis" EXACT []
is_a: MP:0008986 ! abnormal liver parenchyma morphology
is_a: MP:0013332 ! peliosis

[Term]
id: MP:0013336
name: pituitary gland hypertrophy
def: "increase in the bulk size of the pituitary gland due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic hypophysis" EXACT []
synonym: "hypertrophic pituitary gland" EXACT []
synonym: "hypophysis hypertrophy" EXACT []
is_a: MP:0000636 ! enlarged pituitary gland

[Term]
id: MP:0013337
name: abnormal adenohypophysis development
def: "aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke's) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal adenophysis development" EXACT []
synonym: "abnormal anterior pituitary development" EXACT []
synonym: "abnormal anterior pituitary gland development" EXACT []
synonym: "abnormal anterior pituitary lobe development" EXACT []
is_a: MP:0003816 ! abnormal pituitary gland development
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0013338
name: abnormal neurohypophysis development
def: "aberrant formation or incomplete differentiation of the posterior lobe of the pituitary gland which develops as a neurohypophyseal bud, a depression in the neuroectoderm of the floor of the hypothalamus; the infundibulum, another diverticulum from the inferior aspect of the diencephalon, develops as an outgrowth of the neurohypophyseal bud and connects the neurohypophysis to the hypothalamus; the neurohypophysis develops as the infundibulum grows inferiorly from the diencephalon to meet the developing adenohypophysis (anterior pituitary lobe); the fully developed neurohypophysis consists of the infundibulum and the pars nervosa; the neural connection between the hypothalamus and pars nervosa is through the hypothalamohypophyseal tract that develops within the infundibulum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal neurophysis development" EXACT []
synonym: "abnormal posterior pituitary development" EXACT []
synonym: "abnormal posterior pituitary gland development" EXACT []
synonym: "abnormal posterior pituitary lobe development" EXACT []
is_a: MP:0003816 ! abnormal pituitary gland development
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0013339
name: abnormal neurohypophyseal bud morphology
def: "any structural anomaly of the outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003816 ! abnormal pituitary gland development

[Term]
id: MP:0013340
name: abnormal pituicyte morphology
def: "any structural anomaly of the distinctive fusiform cells present in the pars nervosa of the posterior pituitary gland which resemble astrocytes/glial cells of the CNS and assist in the storage and release of neurohypophysial hormones" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002182 ! abnormal astrocyte morphology
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0013341
name: abnormal folliculo-stellate cell morphology
def: "any structural anomaly of the star-shaped and follicle-forming cells in the anterior pituitary gland that stain positive for S-100 protein (a marker for FS-cells); ascribed functions include the formation of an extensive and complex tridimentional network, scavenger activity by engulfing degenerated cells, paracrine regulation of endocrine cells by producing various growth factors and cytokines, such as interleukin-6, leukemia inhibitory factor, basic fibroblastic growth factor, vascular endothelial cell growth factor and follistatin, and large-scale inter-cellular communication by means of their long cytoplasmic processes and gap junctions" [https://orcid.org/0000-0002-6490-7723, PMID:18601690]
synonym: "abnormal folliculostellate cell morphology" EXACT []
synonym: "abnormal FS-cell morphology" EXACT []
synonym: "abnormal FS-cells" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0013342
name: bifurcated Rathke's pouch
def: "the appearance of an abnormal division in the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [https://orcid.org/0000-0002-6490-7723, PMID:19074474]
synonym: "bifurcated craniobuccal pouch" EXACT []
synonym: "bifurcated craniopharyngeal pouch" EXACT []
synonym: "bifurcated hypophyseal pouch" EXACT []
synonym: "bifurcated Rathke's diverticulum" EXACT []
synonym: "bifurcated Rathke's pocket" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology

[Term]
id: MP:0013343
name: abnormal pituitary gland apoptosis
def: "change in the timing or the number of any pituitary gland cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pituitary apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005646 ! abnormal pituitary gland physiology

[Term]
id: MP:0013344
name: increased pituitary gland apoptosis
def: "increase in the number of any cells of the pituitary gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased pituitary apoptosis" EXACT []
is_a: MP:0012504 ! increased forebrain apoptosis
is_a: MP:0013343 ! abnormal pituitary gland apoptosis

[Term]
id: MP:0013345
name: decreased pituitary gland apoptosis
def: "decrease in the number of any cells of the pituitary gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased pituitary apoptosis" EXACT []
synonym: "reduced pituitary apoptosis" EXACT []
synonym: "reduced pituitary gland apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0013343 ! abnormal pituitary gland apoptosis

[Term]
id: MP:0013346
name: increased melanotroph apoptosis
def: "increase in the number of cells of the intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased melanocyte stimulating hormone secreting cell apoptosis" EXACT []
synonym: "increased melanotrope apoptosis" EXACT []
is_a: MP:0013344 ! increased pituitary gland apoptosis

[Term]
id: MP:0013347
name: increased corticotroph apoptosis
def: "increase in the number of anterior pituitary ACTH-producing basophilic cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased adrenocorticotrophic hormone secreting cell apoptosis" EXACT []
synonym: "increased corticotrope apoptosis" EXACT []
synonym: "increased corticotrophin hormone secreting cell apoptosis" EXACT []
synonym: "increased corticotropin hormone secreting cell apoptosis" EXACT []
synonym: "increased pituitary ACTH-producing cell apoptosis" EXACT []
synonym: "increased pituitary adrenocorticotropin-secreting cell apoptosis" EXACT []
is_a: MP:0013344 ! increased pituitary gland apoptosis

[Term]
id: MP:0013348
name: adenohypophysis hyperplasia
def: "increase in the number of normal cells in normal arrangement in the adenohypophysis, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "adenophysis hyperplasia" EXACT []
synonym: "anterior pituitary gland hyperplasia" EXACT []
synonym: "anterior pituitary lobe hyperplasia" EXACT []
synonym: "hyperplastic adenohypophysis" EXACT []
synonym: "hyperplastic adenophysis" EXACT []
synonym: "hyperplastic anterior pituitary gland" EXACT []
synonym: "hyperplastic anterior pituitary lobe" EXACT []
is_a: MP:0008366 ! enlarged adenohypophysis

[Term]
id: MP:0013349
name: small Rathke's pouch
def: "reduced size of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased Rathke's pouch size" EXACT []
synonym: "reduced Rathke's pouch size" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology

[Term]
id: MP:0013350
name: Rathke's pouch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the Rathke's pouch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic Rathke's pouch" EXACT []
is_a: MP:0013349 ! small Rathke's pouch

[Term]
id: MP:0013351
name: abnormal Rathke's pouch development
def: "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Rathke's pouch formation" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology

[Term]
id: MP:0013352
name: abnormal Rathke's pouch apoptosis
def: "any change in the timing or number of Rathke's pouch cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology

[Term]
id: MP:0013353
name: Rathke cleft cyst
def: "presence of one or more intrasellar or suprasellar cysts lined by cuboidal epithelium derived from remnants of the Rathke pouch" [https://orcid.org/0000-0002-6490-7723]
synonym: "Rathke cleft cysts" EXACT []
synonym: "Rathke cyst" EXACT []
synonym: "Rathke cysts" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0013354
name: increased Rathke pouch tumor incidence
def: "a suprasellar neoplasm, usually cystic, that develops from the nests of epithelium derived from Rathke pouch" [http://medical-dictionary.thefreedictionary.com/craniopharyngioma, https://orcid.org/0000-0002-6490-7723]
synonym: "increased craniopharyngioma incidence" EXACT []
synonym: "increased Erdheim tumor incidence" EXACT []
synonym: "increased Erdheim tumour incidence" EXACT []
synonym: "increased hypophyseal duct tumor incidence" EXACT []
synonym: "increased hypophyseal duct tumour incidence" EXACT []
synonym: "increased pituitary adamantinoma incidence" EXACT []
synonym: "increased pituitary ameloblastoma incidence" EXACT []
synonym: "increased Rathke pouch tumour incidence" EXACT []
is_a: MP:0010320 ! increased pituitary gland tumor incidence

[Term]
id: MP:0013355
name: adenohypophysis hypertrophy
def: "increase in the bulk size of the anterior lobe of the pituitary gland due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "adenophysis hypertrophy" EXACT []
synonym: "anterior pituitary gland hypertrophy" EXACT []
synonym: "anterior pituitary lobe hypertrophy" EXACT []
synonym: "hypertrophic adenohypophysis" EXACT []
synonym: "hypertrophic adenophysis" EXACT []
synonym: "hypertrophic anterior pituitary gland" EXACT []
synonym: "hypertrophic anterior pituitary lobe" EXACT []
is_a: MP:0008366 ! enlarged adenohypophysis

[Term]
id: MP:0013356
name: ectopic pituitary gland
def: "a pituitary gland located outside of its normal position" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic hypophysis" EXACT []
synonym: "ectopic pituitary tissue" EXACT []
is_a: MP:0000633 ! abnormal pituitary gland morphology

[Term]
id: MP:0013357
name: ectopic adenohypophysis
def: "an anterior pituitary gland located outside of its normal position due to arrest of migration from a pharyngeocranial location to the sellar region; a portion or all of the adenohypophysis may persist in the pathway of the pharyngeal pouch, either in the nasopharyngeal wall or within the sphenoid bone" [https://orcid.org/0000-0002-6490-7723, PMID:19093031]
synonym: "ectopic adenophysis" EXACT []
synonym: "ectopic anterior pituitary gland" EXACT []
synonym: "ectopic anterior pituitary lobe" EXACT []
synonym: "ectopic nasopharyngeal pituitary" EXACT []
synonym: "ectopic pituitary anterior lobe" EXACT []
is_a: MP:0004163 ! abnormal adenohypophysis morphology

[Term]
id: MP:0013358
name: ectopic neurohypophysis
def: "a posterior pituitary gland displaced distally in the infundibulum (pituitary stalk) due to defective neuronal migration during embryogenesis, tumors, trauma, or surgical transection of the pituitary stalk; may present with an empty pituitary fossa, hypoplasia or absence of the infundibular stalk and resultant short stature due to growth hormone deficiency; the location of the ectopic lobe can vary, but it is most commonly located along the median eminence in the floor of the third ventricle" [https://orcid.org/0000-0002-6490-7723, PMID:24209704]
synonym: "ectopic neurophysis" EXACT []
synonym: "ectopic pituitary posterior lobe" EXACT []
synonym: "ectopic posterior pituitary gland" EXACT []
synonym: "ectopic posterior pituitary lobe" EXACT []
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0013359
name: abnormal pinealocyte morphology
def: "any structural anomaly of the principal cell of the pineal gland, characterized by two or more long cell processes ending in bulbous expansions that terminate in perivascular spaces surrounding capillaries; pinealocytes are secretory cells organized into cords and clusters resting on a basal lamina and surrounded by connective tissue, blood vessels lined by fenestrated endothelial cells, and nerves; their cytoplasm contains abundant mitochondria and multiple synaptic ribbons that are randomly distributed; the primary function of the pinealocytes is the secretion of melatonin; pinealocytes receive a direct innervation from sympathetic neurons that form recognizable synapses" [CL:0000652, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal chief cell of corpus pineale" EXACT []
synonym: "abnormal parenchymatous cell of corpus pineale" EXACT []
synonym: "abnormal pineal parenchymal cell morphology" EXACT []
synonym: "abnormal pineocyte morphology" EXACT []
synonym: "abnormal pinocyte morphology" EXACT []
is_a: MP:0000632 ! abnormal pineal gland morphology

[Term]
id: MP:0013360
name: abnormal pineal recess morphology
def: "any structural anomaly of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland" [https://orcid.org/0000-0002-6490-7723, ISBN:068340007X]
synonym: "abnormal pineal recess of third ventricle morphology" EXACT []
synonym: "abnormal recessus pinealis morphology" EXACT []
is_a: MP:0000826 ! abnormal third ventricle morphology

[Term]
id: MP:0013361
name: absent pineal recess
def: "absence of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland" [https://orcid.org/0000-0002-6490-7723, ISBN:068340007X]
synonym: "absent recessus pinealis" EXACT []
is_a: MP:0013360 ! abnormal pineal recess morphology

[Term]
id: MP:0013362
name: absent pineal gland
def: "absence of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent conarium" EXACT []
synonym: "absent epiphysis cerebri" EXACT []
synonym: "absent glandula pinealis" EXACT []
synonym: "absent pineal body" EXACT []
synonym: "apinealism" EXACT []
is_a: MP:0000632 ! abnormal pineal gland morphology

[Term]
id: MP:0013363
name: abnormal pineal gland development
def: "aberrant formation or incomplete differentiation of the pineal gland which normally develops from a saccular outpocketing of the posterior diencephalic roof in the midline of the third ventricle; continued diverticulation and infolding result in a solid parenchymal mass of cords and clusters of pinealocytes and glial-like interstitial cells supported by a meninges-derived connective tissue that carries blood vessels and nerves to the pineal gland" [https://orcid.org/0000-0002-6490-7723, https://www.inkling.com/read/histology-cell-biology-kierszenbaum-tres-3rd/chapter-18/pineal-gland]
synonym: "abnormal conarium development" EXACT []
synonym: "abnormal corpus pineale development" EXACT []
synonym: "abnormal epiphysis cerebri development" EXACT []
synonym: "abnormal glandula pinealis development" EXACT []
synonym: "abnormal pineal body development" EXACT []
synonym: "abnormal pineal development" BROAD []
is_a: MP:0000632 ! abnormal pineal gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013364
name: enlarged pineal gland
def: "increased size of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged conarium" EXACT []
synonym: "enlarged epiphysis cerebri" EXACT []
synonym: "enlarged glandula pinealis" EXACT []
synonym: "enlarged pineal body" EXACT []
synonym: "increased pineal body size" EXACT []
synonym: "increased pineal gland size" EXACT []
is_a: MP:0000632 ! abnormal pineal gland morphology

[Term]
id: MP:0013365
name: increased pineal gland tumor incidence
def: "greater than the expected number of neoplams in the pineal gland occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased pineal body tumor incidence" EXACT []
synonym: "increased pineal body tumour incidence" EXACT []
synonym: "increased pineal gland tumour incidence" EXACT []
synonym: "pineal tumor" RELATED []
synonym: "pineal tumour" RELATED []
synonym: "pinealoma" RELATED []
is_a: MP:0000632 ! abnormal pineal gland morphology
is_a: MP:0010281 ! increased nervous system tumor incidence
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0013366
name: adrenal gland atrophy
def: "acquired diminution of the size of the pair of endocrine glands located above the kidney and responsible for steroid hormone secretion from the cortex and neurotransmitter secretion from the medulla, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic adrenal glands" EXACT []
is_a: MP:0002768 ! small adrenal glands

[Term]
id: MP:0013367
name: parotid gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "parotitis" EXACT []
is_a: MP:0001870 ! salivary gland inflammation
is_a: MP:0013532 ! abnormal parotid gland physiology

[Term]
id: MP:0013368
name: abnormal sweat gland physiology
def: "any functional anomaly of the coiled tubular glands of the skin that secrete sweat" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal sweat response" EXACT []
synonym: "sudomotor dysfunction" EXACT []
synonym: "sweating dysfunction" EXACT []
is_a: MP:0010680 ! abnormal skin adnexa physiology
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0013369
name: abnormal sweat gland secretion
def: "altered ability of the coiled tubular glands of the skin to produce or secrete sweat in response to appropriate stimuli" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013368 ! abnormal sweat gland physiology

[Term]
id: MP:0013370
name: anhidrosis
def: "complete absence of sweating in response to appropriate stimuli" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent sweating" EXACT []
is_a: MP:0013369 ! abnormal sweat gland secretion

[Term]
id: MP:0013371
name: hypohidrosis
def: "decreased sweating in response to appropriate stimuli" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced sweating" EXACT []
is_a: MP:0013369 ! abnormal sweat gland secretion

[Term]
id: MP:0013372
name: hyperhidrosis
def: "abnormally increased sweating in response to appropriate stimuli" [https://orcid.org/0000-0002-6490-7723]
synonym: "excessive sweating" EXACT []
is_a: MP:0013369 ! abnormal sweat gland secretion

[Term]
id: MP:0013373
name: increased sebum secretion
def: "increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species" [https://orcid.org/0000-0002-6490-7723]
synonym: "excessive sebum production" EXACT []
synonym: "increased sebum production" EXACT []
is_a: MP:0002991 ! abnormal sebaceous gland physiology

[Term]
id: MP:0013374
name: increased sebaceous gland tumor incidence
def: "greater than the expected number of neoplams in the sebaceous gland occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased sebaceous gland tumour incidence" EXACT []
is_a: MP:0000647 ! abnormal sebaceous gland morphology
is_a: MP:0010288 ! increased gland tumor incidence

[Term]
id: MP:0013375
name: abnormal sebocyte morphology
def: "any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "abnormal acinar cell of sebaceous gland morphology" EXACT []
synonym: "abnormal sebaceous epithelial cell morphology" EXACT []
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0013376
name: abnormal sebocyte differentiation
def: "abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "abnormal acinar cell of sebaceous gland differentiation" EXACT []
synonym: "abnormal sebaceous epithelial cell differentiation" EXACT []
is_a: MP:0013375 ! abnormal sebocyte morphology
is_a: MP:0020982 ! abnormal skin adnexa development

[Term]
id: MP:0013377
name: abnormal sebocyte number
def: "any deviation from the normal numbers of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "abnormal acinar cell of sebaceous gland number" EXACT []
synonym: "abnormal sebaceous epithelial cell number" EXACT []
is_a: MP:0013375 ! abnormal sebocyte morphology

[Term]
id: MP:0013378
name: increased sebocyte number
def: "greater than expected number of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "increased acinar cell of sebaceous gland number" EXACT []
synonym: "increased sebaceous epithelial cell number" EXACT []
is_a: MP:0013377 ! abnormal sebocyte number

[Term]
id: MP:0013379
name: decreased sebocyte cell number
def: "fewer than expected number of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "decreased acinar cell of sebaceous gland number" EXACT []
synonym: "decreased sebaceous epithelial cell number" EXACT []
synonym: "reduced acinar cell of sebaceous gland number" EXACT []
synonym: "reduced sebaceous epithelial cell number" EXACT []
synonym: "reduced sebocyte cell number" EXACT []
is_a: MP:0013377 ! abnormal sebocyte number

[Term]
id: MP:0013380
name: absent sebocyte
def: "failure of formation or loss of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "absent acinar cell of sebaceous gland" EXACT []
synonym: "absent sebaceous epithelial cells" EXACT []
is_a: MP:0013379 ! decreased sebocyte cell number

[Term]
id: MP:0013381
name: abnormal perianal sebaceous gland morphology
def: "any structural anomaly of the modified holocrine gland that is part of the pilosebaceous unit of a hair located in the area around the anus; each of the specialized large hair follicles that surround and form a network around the anus has a pair of large sebaceous glands that empty into the follicle; perianal glands may function as scent glands" [https://orcid.org/0000-0002-6490-7723, https://www.inkling.com/read/treuting-comparative-anatomy-histology-1st/chapter-23/mouse-perianal-hair-follicle]
synonym: "abnormal anal gland morphology" EXACT []
synonym: "abnormal circumanal gland morphology" RELATED []
synonym: "abnormal perianal gland morphology" RELATED []
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0013382
name: small perianal sebaceous gland
def: "decreased size of the modified holocrine gland that is part of the pilosebaceous unit of a hair located in the area around the anus; each of the specialized large hair follicles that surround and form a network around the anus has a pair of large sebaceous glands that empty into the follicle; perianal glands may function as scent glands" [https://orcid.org/0000-0002-6490-7723, https://www.inkling.com/read/treuting-comparative-anatomy-histology-1st/chapter-23/mouse-perianal-hair-follicle]
synonym: "decreased anal gland size" EXACT []
synonym: "decreased circumanal gland size" RELATED []
synonym: "decreased perianal gland size" RELATED []
synonym: "decreased perianal sebaceous gland size" EXACT []
synonym: "reduced anal gland size" EXACT []
synonym: "reduced circumanal gland size" RELATED []
synonym: "reduced perianal gland size" RELATED []
synonym: "reduced perianal sebaceous gland size" EXACT []
synonym: "small anal gland" EXACT []
synonym: "small circumanal gland" RELATED []
synonym: "small perianal gland" RELATED []
is_a: MP:0012725 ! small sebaceous gland
is_a: MP:0013381 ! abnormal perianal sebaceous gland morphology

[Term]
id: MP:0013383
name: increased sebaceous gland adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "sebaceous adenoma" RELATED []
is_a: MP:0010383 ! increased adenoma incidence
is_a: MP:0013374 ! increased sebaceous gland tumor incidence

[Term]
id: MP:0013384
name: abnormal Zymbal's gland morphology
def: "any structural anomaly of either of the paired multilobulated modified auditory sebaceous glands located anterior and ventral to the exterior ear canal in rodents; each gland consists of acinar sebaceous cells and excretory ducts lined by stratified squamous epithelium; the ducts of Zymbal's gland empty into the external ear canal" [https://orcid.org/0000-0002-6490-7723, ISBN:012382009X, ISBN:1439872104]
synonym: "abnormal auditory sebaceous gland morphology" EXACT []
synonym: "abnormal gland of Zymbal morphology" EXACT []
synonym: "abnormal Zymbal gland morphology" EXACT []
is_a: MP:0000647 ! abnormal sebaceous gland morphology

[Term]
id: MP:0013385
name: abnormal Meibomian gland development
def: "aberrant formation or incomplete differentiation of the sebaceous glands located at the rim of the eyelids inside the tarsal plate and responsible for the supply of meibum, an oily substance that prevents evaporation of the eye's tear film; in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening" [PMID:20664693]
synonym: "abnormal tarsal gland development" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology
is_a: MP:0020973 ! abnormal gland development
is_a: MP:0020982 ! abnormal skin adnexa development

[Term]
id: MP:0013386
name: enlarged Meibomian gland
def: "increased size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged tarsal gland" EXACT []
synonym: "increased meibomian gland size" EXACT []
synonym: "increased tarsal gland size" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology

[Term]
id: MP:0013387
name: Meibomian gland hypertrophy
def: "increase in the bulk size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic meibomian gland" EXACT []
synonym: "hypertrophic tarsal gland" EXACT []
synonym: "tarsal gland hypertrophy" EXACT []
is_a: MP:0013386 ! enlarged Meibomian gland

[Term]
id: MP:0013388
name: small Meibomian gland
def: "decreased size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased meibomian gland size" EXACT []
synonym: "decreased tarsal gland size" EXACT []
synonym: "reduced meibomian gland size" EXACT []
synonym: "reduced tarsal gland size" EXACT []
synonym: "small tarsal gland" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology

[Term]
id: MP:0013389
name: Meibomian gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the Meibomian gland, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic meibomian gland" EXACT []
synonym: "hypoplastic tarsal gland" EXACT []
synonym: "tarsal gland hypoplasia" EXACT []
is_a: MP:0013193 ! sebaceous gland hypoplasia
is_a: MP:0013388 ! small Meibomian gland

[Term]
id: MP:0013390
name: Meibomian gland cyst
def: "presence of one or more non-malignant fluid-filled cysts in the eyelid area due to non-infectious obstruction or malfunctioning of a Meibomian gland causing extravasation of lipid material in the eyelid soft tissues with focal secondary granulomatous inflammation" [https://orcid.org/0000-0002-6490-7723]
synonym: "chalazia" EXACT []
synonym: "chalazion" EXACT []
synonym: "cystic Meibomian gland" EXACT []
synonym: "cystic tarsal gland" EXACT []
synonym: "eyelid lump" EXACT []
synonym: "Meibomian cyst" EXACT []
synonym: "Meibomian cysts" EXACT []
synonym: "Meibomian gland cysts" EXACT []
synonym: "Meibomian gland lipogranuloma" EXACT []
synonym: "Meibomian gland lipogranulomas" EXACT []
synonym: "tarsal cyst" EXACT []
synonym: "tarsal cysts" EXACT []
synonym: "tarsal gland cyst" EXACT []
synonym: "tarsal gland cysts" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0013391
name: abnormal Meibomian gland physiology
def: "any functional anomaly of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; dysfunctional Meibomian glands may produce an excessive amount of oil, cause dry eyes, or contribute to blepharitis" [https://orcid.org/0000-0002-6490-7723]
synonym: "Meibomian gland dysfunction" EXACT []
is_a: MP:0002991 ! abnormal sebaceous gland physiology

[Term]
id: MP:0013392
name: Meibomian gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; chronic Meibomian gland inflammation can lead to a lump in the eyelid known as a Meibomian gland cyst (aka chalazion)" [https://orcid.org/0000-0002-6490-7723]
synonym: "meibomianitis" EXACT []
synonym: "meibomitis" EXACT []
synonym: "posterior blepharitis" EXACT []
is_a: MP:0005251 ! blepharitis
is_a: MP:0013391 ! abnormal Meibomian gland physiology

[Term]
id: MP:0013393
name: symblepharon
def: "partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball" [https://orcid.org/0000-0002-6490-7723]
comment: Symblepharon is rarely a congenital defect and this condition usually results from trauma such as burns.
synonym: "atretoblepharia" EXACT []
synonym: "palpebral-bulbar adhesion" EXACT []
is_a: MP:0013394 ! abnormal palpebral conjunctiva morphology
is_a: MP:0013402 ! abnormal bulbar conjunctiva morphology

[Term]
id: MP:0013394
name: abnormal palpebral conjunctiva morphology
def: "any structural anomaly of the thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies" [ISBN:068340007X]
synonym: "abnormal conjunctival layer of eyelids morphology" EXACT []
is_a: MP:0001310 ! abnormal conjunctiva morphology
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0013395
name: eyelid hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the eyelid, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "eye lid hypoplasia" EXACT []
synonym: "hypoplastic eye lid" EXACT []
synonym: "hypoplastic eyelid" EXACT []
synonym: "hypoplastic eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0013396
name: eyelid hyperplasia
def: "increase in the number of normal cells in normal arrangement in the eyeball, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "eye lid hyperplasia" EXACT []
synonym: "hyperplastic eye lid" EXACT []
synonym: "hyperplastic eyelid" EXACT []
synonym: "hyperplastic eyelids" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0013397
name: abnormal Zeis gland morphology
def: "any structural anomaly of the unilobar sebaceous glands located on the margin of the eyelid that service the eyelash; these glands produce an oily substance that is issued through the excretory ducts of the sebaceous lobule into the middle portion of the hair follicle" [http://en.wikipedia.org/wiki/Gland_of_Zeis, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ciliary sebaceous gland of eyelid" EXACT []
synonym: "abnormal gland of Zeis morphology" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology
is_a: MP:0009535 ! abnormal skin sebaceous gland morphology

[Term]
id: MP:0013398
name: uterus fibrosis
def: "invasion of fibrous connective tissue into the uterus, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "metra fibrosis" EXACT []
synonym: "metral fibrosis" EXACT []
synonym: "uterine fibrosis" EXACT []
is_a: MP:0001120 ! abnormal uterus morphology

[Term]
id: MP:0013399
name: endometrium fibrosis
def: "invasion of fibrous connective tissue into the endometrium, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "endometrial fibrosis" EXACT []
is_a: MP:0004896 ! abnormal endometrium morphology
is_a: MP:0013398 ! uterus fibrosis

[Term]
id: MP:0013400
name: abnormal endometrial gland development
def: "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [https://orcid.org/0000-0002-6490-7723, PMID:23619340]
synonym: "abnormal uterine gland development" EXACT []
synonym: "endometrial gland dysgenesis" EXACT []
synonym: "uterine gland dysgenesis" EXACT []
is_a: MP:0003936 ! abnormal reproductive system development
is_a: MP:0009094 ! abnormal endometrial gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013401
name: increased endometrial gland number
def: "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased uterine gland number" EXACT []
is_a: MP:0009095 ! abnormal endometrial gland number

[Term]
id: MP:0013402
name: abnormal bulbar conjunctiva morphology
def: "any structural anomaly of the conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea" [ISBN:068340007X]
synonym: "abnormal conjunctival layer of bulb morphology" EXACT []
synonym: "abnormal ocular conjunctiva morphology" EXACT []
is_a: MP:0001310 ! abnormal conjunctiva morphology

[Term]
id: MP:0013403
name: abnormal circulating lactate level
def: "any anomaly of the amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
comment: Lactate levels in the blood are used as an index of anerobic carbohydrate metabolism.
is_a: MP:0009642 ! abnormal blood homeostasis

[Term]
id: MP:0013404
name: decreased circulating lactate level
def: "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
is_a: MP:0013403 ! abnormal circulating lactate level

[Term]
id: MP:0013405
name: increased circulating lactate level
def: "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
is_a: MP:0013403 ! abnormal circulating lactate level

[Term]
id: MP:0013406
name: abnormal epidermal immune compartment
def: "any anomaly in the constitution or organization of the immune cells residing in the skin epidermal layer" [IMPC:Saran]
is_a: MP:0001216 ! abnormal epidermal layer morphology

[Term]
id: MP:0013407
name: abnormal dendritic epidermal T cell morphology
def: "any structural anomaly of T cells with dendritic appearance residing in the skin epidermis, usually expressing a canonical gamma-delta T cell receptor and is involved in the regulation of wound healing" [IMPC:Saran] {comment="CL:0000916"}
synonym: "abnormal dendritic epidermal T lymphocyte morphology" EXACT []
synonym: "abnormal dendritic epidermal T-cell morphology" EXACT []
synonym: "abnormal dendritic epidermal T-lymphocyte morphology" EXACT []
synonym: "abnormal DETC morphology" EXACT []
is_a: MP:0008344 ! abnormal mature gamma-delta T cell morphology
is_a: MP:0013406 ! abnormal epidermal immune compartment

[Term]
id: MP:0013408
name: abnormal dendritic epidermal T cell number
def: "anomaly in the number of T cells with dendritic appearance residing in the skin epidermis, usually expressing a canonical gamma-delta T cell receptor and is involved in the regulation of wound healing" [CL:0000916, https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008345 ! abnormal gamma-delta T cell number
is_a: MP:0013407 ! abnormal dendritic epidermal T cell morphology

[Term]
id: MP:0013409
name: increased dendritic epidermal T cell number
def: "increase in the number of T cells with dendritic appearance residing in the skin epidermis, usually expressing a canonical gamma-delta T cell receptor and is involved in the regulation of wound healing" [CL:0000916, https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008346 ! increased gamma-delta T cell number
is_a: MP:0013408 ! abnormal dendritic epidermal T cell number

[Term]
id: MP:0013410
name: decreased dendritic epidermal T cell number
def: "reduction in the number of T cells with dendritic appearance residing in the skin epidermis, usually expressing a canonical gamma-delta T cell receptor and is involved in the regulation of wound healing" [CL:0000916, https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008347 ! decreased gamma-delta T cell number
is_a: MP:0013408 ! abnormal dendritic epidermal T cell number

[Term]
id: MP:0013411
name: abnormal Langerhans cell number
def: "anomaly in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [IMPC:Saran, ISBN:0781735149]
is_a: MP:0008117 ! abnormal Langerhans cell morphology

[Term]
id: MP:0013412
name: increased Langerhans cell number
def: "increase in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [IMPC:Saran, ISBN:0781735149]
is_a: MP:0013411 ! abnormal Langerhans cell number

[Term]
id: MP:0013413
name: abnormal myeloid cell number in bone marrow
def: "any anomaly in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
is_a: MP:0000172 ! abnormal bone marrow cell number
is_a: MP:0013661 ! abnormal myeloid cell number

[Term]
id: MP:0013414
name: decreased myeloid cell number in bone marrow
def: "reduction in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
is_a: MP:0013413 ! abnormal myeloid cell number in bone marrow
is_a: MP:0013662 ! decreased myeloid cell number

[Term]
id: MP:0013415
name: increased myeloid cell number in bone marrow
def: "increase in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
is_a: MP:0013413 ! abnormal myeloid cell number in bone marrow
is_a: MP:0013663 ! increased myeloid cell number

[Term]
id: MP:0013416
name: abnormal memory-marker gamma-delta T cell number
def: "anomaly in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype" [IMPC:Saran, PMID:23928962]
is_a: MP:0008345 ! abnormal gamma-delta T cell number

[Term]
id: MP:0013417
name: decreased memory-marker gamma-delta T cell number
def: "reduction in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype" [IMPC:Saran, PMID:23928962]
synonym: "reduced memory-marker gamma-delta T cell number" EXACT []
is_a: MP:0008347 ! decreased gamma-delta T cell number
is_a: MP:0013416 ! abnormal memory-marker gamma-delta T cell number

[Term]
id: MP:0013418
name: increased memory-marker gamma-delta T cell number
def: "increase in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype" [IMPC:Saran, PMID:23928962]
is_a: MP:0008346 ! increased gamma-delta T cell number
is_a: MP:0013416 ! abnormal memory-marker gamma-delta T cell number

[Term]
id: MP:0013419
name: abnormal CD5-positive gamma-delta T cell number
def: "anomaly in the number of CD5+ gamma-delta T cells" [IMPC:Saran, PMID:23928962]
is_a: MP:0008345 ! abnormal gamma-delta T cell number

[Term]
id: MP:0013420
name: decreased CD5-positive gamma-delta T cell number
def: "reduction in the number of CD5+ gamma-delta T cells" [IMPC:Saran]
synonym: "reduced CD5-positive gamma-delta T cell number" EXACT []
is_a: MP:0008347 ! decreased gamma-delta T cell number
is_a: MP:0013419 ! abnormal CD5-positive gamma-delta T cell number

[Term]
id: MP:0013421
name: increased CD5-positive gamma-delta T cell number
def: "increase in the number of CD5+ gamma-delta T cells" [IMPC:Saran]
is_a: MP:0008346 ! increased gamma-delta T cell number
is_a: MP:0013419 ! abnormal CD5-positive gamma-delta T cell number

[Term]
id: MP:0013422
name: abnormal KLRG1-positive gamma-delta T cell number
def: "anomaly in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
is_a: MP:0008345 ! abnormal gamma-delta T cell number

[Term]
id: MP:0013423
name: decreased KLRG1-positive gamma-delta T cell number
def: "reduction in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
synonym: "reduced KLRG+ gamma-delta T cell number" EXACT []
is_a: MP:0008347 ! decreased gamma-delta T cell number
is_a: MP:0013422 ! abnormal KLRG1-positive gamma-delta T cell number

[Term]
id: MP:0013424
name: increased KLRG1-positive gamma-delta T cell number
def: "increase in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
is_a: MP:0008346 ! increased gamma-delta T cell number
is_a: MP:0013422 ! abnormal KLRG1-positive gamma-delta T cell number

[Term]
id: MP:0013425
name: abnormal memory-marker NK cell number
def: "anomaly in the number of memory-marker NK cells with a CD44+ CD62L- phenotype" [IMPC:Saran]
is_a: MP:0008043 ! abnormal NK cell number

[Term]
id: MP:0013426
name: decreased memory-marker NK cell number
def: "reduction in the number of memory-marker NK cells with a CD44+ CD62L- phenotype" [IMPC:Saran]
synonym: "reduced memory-marker NK cell number" EXACT []
is_a: MP:0008045 ! decreased NK cell number
is_a: MP:0013425 ! abnormal memory-marker NK cell number

[Term]
id: MP:0013427
name: increased memory-marker NK cell number
def: "increase in the number of memory-marker NK cells with a CD44+ CD62L- phenotype" [IMPC:Saran]
is_a: MP:0008044 ! increased NK cell number
is_a: MP:0013425 ! abnormal memory-marker NK cell number

[Term]
id: MP:0013428
name: abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "anomaly in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype" [IMPC:Saran]
is_a: MP:0012773 ! abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013429
name: decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "reduction in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype" [IMPC:Saran]
is_a: MP:0010169 ! decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
is_a: MP:0013428 ! abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013430
name: increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "increase in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype" [IMPC:Saran]
is_a: MP:0010168 ! increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
is_a: MP:0013428 ! abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013431
name: abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "anomaly in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
is_a: MP:0012773 ! abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013432
name: decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "reduction in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
is_a: MP:0010169 ! decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
is_a: MP:0013431 ! abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013433
name: increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
def: "increase in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
is_a: MP:0010168 ! increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
is_a: MP:0013431 ! abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

[Term]
id: MP:0013434
name: abnormal CD8-positive, naive alpha-beta T cell number
def: "anomaly in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number

[Term]
id: MP:0013435
name: decreased CD8-positive, naive alpha-beta T cell number
def: "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
synonym: "reduced CD8-positive, naive alpha-beta T cell number" EXACT []
is_a: MP:0013434 ! abnormal CD8-positive, naive alpha-beta T cell number

[Term]
id: MP:0013436
name: increased CD8-positive, naive alpha-beta T cell number
def: "increase in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
is_a: MP:0013434 ! abnormal CD8-positive, naive alpha-beta T cell number

[Term]
id: MP:0013437
name: decreased phytosterol level
def: "decreased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [ISBN:0-683-40008-8]
synonym: "decreased plant sterol level" EXACT []
synonym: "reduced phytosterol level" EXACT []
synonym: "reduced plant sterol level" EXACT []
is_a: MP:0010076 ! abnormal phytosterol level
is_a: MP:0012225 ! decreased sterol level

[Term]
id: MP:0013438
name: dysmyelination
def: "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [https://orcid.org/0000-0003-3691-0324]
comment: Dysmyelination refers to malformed and defective myelin sheath as opposed to the destruction of previously normal myelin that is seen in demyelination. Dysmyelination disorders often arise from hereditary mutations that affect the synthesis and formation of myelin.
synonym: "hypomyelination" EXACT []
synonym: "reduced myelination" EXACT []
is_a: MP:0000920 ! abnormal myelination

[Term]
id: MP:0013439
name: abnormal Harderian gland development
def: "aberrant formation or incomplete differentiation of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane; in rodents, the Harderian gland originates from the nasal part of the conjunctival epithelium at E16 and forms a branched structure behind the eyeball; in contrast to the acinar morphology of the lacrimal gland, the Harderian gland has a tubulo-alveolar organization and is composed exclusively of one type of secretory cell; in primates, the HG is either absent or vestigial" [https://orcid.org/0000-0002-6490-7723]
comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages
synonym: "Harderian gland dysgenesis" EXACT []
is_a: MP:0005248 ! abnormal Harderian gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013440
name: abnormal exorbital lacrimal gland morphology
def: "any structural anomaly of the large exorbital (extra-orbital) lacrimal glands that are located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland" [https://orcid.org/0000-0002-6490-7723, ISBN:0123813611]
comment: The mouse has two pairs of lacrimal glands. The larger exorbital (extra-orbital) glands are located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland; the smaller intra-orbital glands are located superficially at the lateral canthus, where both the lacrimal gland and Harderian gland ducts open
synonym: "abnormal extra-orbital lacrimal gland morphology" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0013441
name: abnormal intraorbital lacrimal gland morphology
def: "any structural anomaly of the small intra-orbital lacrimal glands that are located superficially at the lateral canthus, where both the lacrimal gland and Harderian gland ducts open" [https://orcid.org/0000-0002-6490-7723, ISBN:0123813611]
comment: The mouse has two pairs of lacrimal glands. The larger exorbital (extra-orbital) glands are located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland; the smaller intra-orbital glands are located superficially at the lateral canthus, where both the lacrimal gland and Harderian gland ducts open
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0013442
name: abnormal Harderian gland size
def: "anomaly in the average size of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005248 ! abnormal Harderian gland morphology

[Term]
id: MP:0013443
name: Harderian gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the Harderian gland, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic Harderian gland" EXACT []
is_a: MP:0013446 ! enlarged Harderian gland

[Term]
id: MP:0013444
name: Harderian gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the Harderian gland, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic Harderian gland" EXACT []
is_a: MP:0013448 ! small Harderian gland

[Term]
id: MP:0013445
name: Harderian gland atrophy
def: "acquired diminution of the size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic Harderian gland" EXACT []
is_a: MP:0013448 ! small Harderian gland

[Term]
id: MP:0013446
name: enlarged Harderian gland
def: "increased size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased Harderian gland size" EXACT []
is_a: MP:0013442 ! abnormal Harderian gland size

[Term]
id: MP:0013447
name: Harderian gland hypertrophy
def: "increase in the bulk size, due to cell enlargement, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic Harderian gland" EXACT []
is_a: MP:0013446 ! enlarged Harderian gland

[Term]
id: MP:0013448
name: small Harderian gland
def: "decreased size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased Harderian gland size" EXACT []
synonym: "reduced Harderian gland size" EXACT []
is_a: MP:0013442 ! abnormal Harderian gland size

[Term]
id: MP:0013449
name: abnormal lacrimal lake morphology
def: "any structural anomaly of the small cistern-like area of the conjunctiva at the medial angle of the eye, in which the tears collect after bathing the front surface of the eyeball and the conjunctival sac" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lacrymal lake morphology" EXACT []
is_a: MP:0008968 ! abnormal lacrimal apparatus morphology

[Term]
id: MP:0013450
name: abnormal lacrimal apparatus physiology
def: "any functional anomaly of the network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal apparatus lacrimalis physiology" EXACT []
synonym: "abnormal lacrimal system physiology" EXACT []
synonym: "abnormal lacrymal system physiology" EXACT []
synonym: "lacrimal drainage dysfunction" EXACT []
synonym: "lacrymal drainage dysfunction" EXACT []
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0013451
name: nasolacrimal duct obstruction
def: "any impediment or blockage of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity; may be either congenital or acquired; obstruction of the nasolacrimal duct leads to the excess overflow of tears called epiphora" [https://orcid.org/0000-0002-6490-7723]
synonym: "nasolacrimal duct occlusion" EXACT []
synonym: "nasolacrymal duct obstruction" EXACT []
synonym: "nasolacrymal duct occlusion" EXACT []
synonym: "tear-duct blockage" EXACT []
is_a: MP:0008969 ! abnormal nasolacrimal duct morphology

[Term]
id: MP:0013452
name: increased lacrimal gland apoptosis
def: "increase in the number of cells of the lacrimal gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased lachrymal gland apoptosis" EXACT []
is_a: MP:0001348 ! abnormal lacrimal gland physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0013453
name: enlarged lacrimal gland
def: "increased size of any of the paired glands that secrete the aqueous layer of the tear film" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased lacrimal gland size" EXACT []
synonym: "increased lacrymal gland size" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0013454
name: lacrimal gland hypertrophy
def: "increase in the bulk size of any of the paired glands that secrete the aqueous layer of the tear film due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic lacrimal gland" EXACT []
synonym: "hypertrophic lacrymal gland" EXACT []
synonym: "lacrymal gland hypertrophy" EXACT []
is_a: MP:0013453 ! enlarged lacrimal gland

[Term]
id: MP:0013455
name: lacrimal gland atrophy
def: "acquired diminution of the size of any of the paired glands that secrete the aqueous layer of the tear film, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic lacrimal gland" EXACT []
synonym: "atrophic lacrymal gland" EXACT []
synonym: "lacrymal gland atrophy" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0013456
name: abnormal eccrine gland number
def: "aberration in the number of the coiled tubular glands normally situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000675 ! abnormal eccrine sweat gland morphology

[Term]
id: MP:0013457
name: increased eccrine gland number
def: "greater than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present" [https://orcid.org/0000-0002-6490-7723]
synonym: "supernumerary eccrine glands" EXACT []
is_a: MP:0013456 ! abnormal eccrine gland number

[Term]
id: MP:0013458
name: decreased eccrine gland number
def: "fewer than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced eccrine gland number" EXACT []
is_a: MP:0013456 ! abnormal eccrine gland number

[Term]
id: MP:0013459
name: perioral dermatitis
def: "an inflammatory skin condition characterized by multiple small papules, pustules and vesicles localized to the perioral skin (around the mouth), perinasal or nasolabial folds (around the nostrils), or periocular area (around the eyes)" [http://en.wikipedia.org/wiki/Perioral_dermatitis]
synonym: "periorifical dermatitis" EXACT []
is_a: MP:0001194 ! dermatitis

[Term]
id: MP:0013460
name: periocular dermatitis
def: "inflammation of the skin on the eyelids and around the eyes; a variant of perioral dermatitis" [https://orcid.org/0000-0002-6490-7723]
synonym: "periorbital dermatitis" EXACT []
is_a: MP:0013459 ! perioral dermatitis

[Term]
id: MP:0013461
name: abnormal conjunctiva fornix morphology
def: "any structural anomaly of the space formed by the junction of the bulbar and palpebral portions of the conjunctiva, that of the upper lid being the superior conjunctival fornix (fornix conjunctivae superior) and that of the lower lid, the inferior conjunctival fornix (fornix conjunctivae inferior); the fornix is loose and flexible, allowing the free movement of the lids and eyeball" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal conjunctival cul-de-sac morphology" EXACT []
synonym: "abnormal conjunctival fornix morphology" EXACT []
synonym: "abnormal fornix conjunctiva morphology" EXACT []
synonym: "abnormal fornix conjunctivae morphology" EXACT []
synonym: "abnormal retrotarsal fold morphology" EXACT []
is_a: MP:0001310 ! abnormal conjunctiva morphology

[Term]
id: MP:0013462
name: abnormal conjunctiva goblet cell number
def: "aberration in the number of the mucin-secreting cells found on the conjunctival epithelium; changes in goblet cell numbers are associated with alterations in tear mucin level" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal conjunctival goblet cell count" EXACT []
synonym: "abnormal conjunctival goblet cell number" EXACT []
is_a: MP:0012164 ! abnormal conjunctiva goblet cell morphology

[Term]
id: MP:0013463
name: increased conjunctiva goblet cell number
def: "greater than normal numbers of the mucin-secreting cells found on the conjunctival epithelium" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased conjunctival goblet cell count" EXACT []
synonym: "increased conjunctival goblet cell number" EXACT []
is_a: MP:0013462 ! abnormal conjunctiva goblet cell number

[Term]
id: MP:0013464
name: decreased conjunctiva goblet cell number
def: "fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens's syndrome" [https://orcid.org/0000-0002-6490-7723]
synonym: "conjunctiva goblet cell depletion" EXACT []
synonym: "conjunctiva goblet cell loss" EXACT []
synonym: "reduced conjunctival goblet cell count" EXACT []
synonym: "reduced conjunctival goblet cell number" EXACT []
is_a: MP:0013462 ! abnormal conjunctiva goblet cell number

[Term]
id: MP:0013465
name: abnormal conjunctiva goblet cell differentiation
def: "abnormal or arrested formation of the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired conjunctiva goblet cell formation" EXACT []
is_a: MP:0012164 ! abnormal conjunctiva goblet cell morphology

[Term]
id: MP:0013466
name: keratoconjunctivitis sicca
def: "inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation" [https://orcid.org/0000-0002-6490-7723]
synonym: "dry eye syndrome" EXACT []
synonym: "keratitis sicca" EXACT []
is_a: MP:0006194 ! keratoconjunctivitis

[Term]
id: MP:0013467
name: diaphragmitis
def: "inflammation of the diaphragm" [https://orcid.org/0000-0002-6490-7723]
synonym: "diaphragm inflammation" EXACT []
synonym: "phrenitis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0013468
name: chromodacryorrhea
def: "shedding of red or blood-stained tears due to continuous or excessive secretion of porphyrin from the Harderian gland; as these secretions overflow from the eye and drain through the nasal passages to exit the nares dark rust-colored staining, or crust, can be seen around the eyes and nostrils; these secretions may be transferred to the paws and muzzle during grooming; red tears may be associated with nutritional deficiencies, chronic physiological stress, chronic light exposure, or dacryoadenitis" [https://orcid.org/0000-0002-6490-7723, PMID:8995755]
synonym: "bloody tears" EXACT []
synonym: "red lacrimal secretion" EXACT []
synonym: "red tears" EXACT []
is_a: MP:0020218 ! abnormal tear production

[Term]
id: MP:0013469
name: abnormal lacrimal gland bud morphology
def: "any structural anomaly of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; between E15.5 and E16.5 the bud undergoes branching morphogenesis, forming both a major extra-orbital lobe and a minor intraorbital lobe" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013331 ! abnormal lacrimal gland development

[Term]
id: MP:0013470
name: absent lacrimal gland bud
def: "absence of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme at E14.5" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lacrimal bud" EXACT []
is_a: MP:0013469 ! abnormal lacrimal gland bud morphology

[Term]
id: MP:0013471
name: small lacrimal gland bud
def: "reduced size of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme at E14.5; following elongation, the bud invades the mesenchymal sac at E16.5 and begins a period of rapid growth and branching to form prospective lobular structures: the intra- and ex-orbital lobes" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lacrimal gland bud size" EXACT []
synonym: "reduced lacrimal gland bud size" EXACT []
is_a: MP:0013469 ! abnormal lacrimal gland bud morphology

[Term]
id: MP:0013472
name: abnormal lacrimal gland bud elongation
def: "anomaly in the process by which the primary lacrimal bud extends caudally into the surrounding neural-crest derived periocular mesenchyme; in mice, the primary bud formed at E13.5 elongates at E14.5; following elongation, the bud invades the mesenchymal sac at E16.5 and begins a period of rapid growth and branching to form prospective lobular structures: the intra- and ex-orbital lobes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013331 ! abnormal lacrimal gland development

[Term]
id: MP:0013473
name: ectopic lacrimal gland bud
def: "lacrimal gland bud(s) are located other than in the normal or expected position" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic lacrimal budding" EXACT []
is_a: MP:0013469 ! abnormal lacrimal gland bud morphology

[Term]
id: MP:0013474
name: abnormal lacrimal gland branching morphogenesis
def: "anomaly of the lacrimal gland bud to repeatedly divide into lobules during development of the lacrimal gland; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; branching is initiated between E15.5 and E16.5 from the tip of the lacrimal bud; by E18.5, the gland consists of an extensively branched exorbital lobe and a small intraocular lobe derived from a single branch of the proximal duct; branching and differentiation of lacrimal glands is complete by around eyelid opening" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013331 ! abnormal lacrimal gland development

[Term]
id: MP:0013475
name: delayed reproductive senescence
def: "loss of reproductive capacity occurring at a later than expected age; often accompanied by inability to carry offspring to term" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002161 ! abnormal fertility/fecundity

[Term]
id: MP:0013476
name: abnormal Harderian gland porphyrin secretion
def: "anomaly in the production and/or release of porphyrin(s), the pigment(s) responsible for the red discoloration of ocular and/or nasal discharges in rodents; in rats, protoporhyrin IX accounts for most of the porphyrin produced and stored in the Harderian gland; in some rodents the concentration of porphyrins in the Harderian glands varies according to gender and species, and tends to be higher in females than in males" [http://ratguide.com/health/eyes/porphyrin_secretions_red_tears.php, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003859 ! abnormal Harderian gland physiology

[Term]
id: MP:0013477
name: abnormal cornea limbus morphology
def: "any structural anomaly of the edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal corneal limbus morphology" EXACT []
synonym: "abnormal corneo-scleral junction morphology" EXACT []
synonym: "abnormal corneoscleral junction morphology" EXACT []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0013478
name: corneal limbitis
def: "inflammation of the corneal limbus" [https://orcid.org/0000-0002-6490-7723]
synonym: "cornea limbus inflammation" EXACT []
synonym: "corneo-scleral junction inflammation" EXACT []
synonym: "corneoscleral junction inflammation" EXACT []
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0013479
name: scleritis
def: "inflammation of the sclera, the tough white outer coat of the eyeball; may impair vision and occur in association with systemic collagen diseases such as rheumatoid arthritis, Wegener's granulomatosis and, less often, lupus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001851 ! eye inflammation

[Term]
id: MP:0013480
name: cyclitis
def: "inflammation of the ciliary body of the eye" [https://orcid.org/0000-0002-6490-7723]
synonym: "ciliary body inflammation" EXACT []
is_a: MP:0005515 ! uveitis

[Term]
id: MP:0013481
name: abnormal ileum crypts of Lieberkuhn morphology
def: "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ileal crypt morphology" EXACT []
synonym: "abnormal ileum crypt morphology" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology
is_a: MP:0004841 ! abnormal small intestine crypts of Lieberkuhn morphology

[Term]
id: MP:0013482
name: abnormal duodenum crypts of Lieberkuhn morphology
def: "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal duodenal crypt morphology" EXACT []
synonym: "abnormal duodenum crypt morphology" EXACT []
is_a: MP:0003271 ! abnormal duodenum morphology
is_a: MP:0004841 ! abnormal small intestine crypts of Lieberkuhn morphology

[Term]
id: MP:0013483
name: abnormal jejunum crypts of Lieberkuhn morphology
def: "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal jejunum crypt morphology" EXACT []
is_a: MP:0004002 ! abnormal jejunum morphology
is_a: MP:0004841 ! abnormal small intestine crypts of Lieberkuhn morphology

[Term]
id: MP:0013484
name: abnormal Paneth cell number
def: "anomaly in the number of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [PMID:23398152]
synonym: "abnormal Davidoff cell number" EXACT []
synonym: "abnormal Paneth granule cell number" EXACT []
is_a: MP:0004843 ! abnormal Paneth cell morphology

[Term]
id: MP:0013485
name: increased Paneth cell number
def: "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased Davidoff cell number" EXACT []
synonym: "increased Paneth granule cell number" EXACT []
is_a: MP:0013484 ! abnormal Paneth cell number

[Term]
id: MP:0013486
name: decreased Paneth cell number
def: "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased Davidoff cell number" EXACT []
synonym: "decreased Paneth granule cell number" EXACT []
synonym: "reduced Davidoff cell number" EXACT []
synonym: "reduced Paneth cell number" EXACT []
synonym: "reduced Paneth granule cell number" EXACT []
is_a: MP:0013484 ! abnormal Paneth cell number

[Term]
id: MP:0013487
name: abnormal Paneth cell physiology
def: "any functional anomaly of the large secretory cells found at the base of the crypts of Lieberkuhn in the small intestine; Paneth cells contribute to the mucosal defense mechanism through the secretion of granules filled with antimicrobial (poly)peptides such as lysozyme, phospholipase A2, and defensins (called cryptdins in mice); Paneth cells secrete factors that help sustain and modulate the epithelial stem and progenitor cells that cohabitate in the crypts of Lieberkuhn and rejuvenate the small intestinal epithelium; dysfunction of Paneth cell biology contributes to the pathogenesis of chronic inflammatory bowel disease" [PMID:23398152]
synonym: "abnormal Davidoff cell physiology" EXACT []
synonym: "abnormal Paneth granule cell physiology" EXACT []
is_a: MP:0010156 ! abnormal small intestinal crypt cell physiology

[Term]
id: MP:0013488
name: increased keratoacanthoma incidence
def: "greater than the expected number of low-grade skin tumors that originate in the pilosebaceous glands and closely resemble squamous cell carcinoma, occurring in a specific population in a given time period; keratoacanthomas are spontaneously regressing growths that rarely develop into invasive or metastatic carcinoma; in rare instances, multiple keratoacanthomas are associated with a disease process called Muir-Torre syndrome" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010300 ! increased skin tumor incidence

[Term]
id: MP:0013489
name: abnormal infundibular recess of third ventricle morphology
def: "any structural anomaly of the funnel-shaped diverticulum that extends downward from the anterior aspect of the floor of the third ventricle into the infundibulum of the hypophysis; the embryonic structure gives rise the neural component of the pituitary (pas nervosa)" [https://orcid.org/0000-0002-6490-7723, PMID:21345181]
synonym: "abnormal infundibular recess morphology" EXACT []
synonym: "abnormal infundibular recess of 3rd ventricle morphology" EXACT []
synonym: "abnormal recessus infundibularis morphology" EXACT []
synonym: "abnormal recessus infundibuli morphology" EXACT []
is_a: MP:0013338 ! abnormal neurohypophysis development

[Term]
id: MP:0013490
name: absent infundibular recess of third ventricle
def: "absence of the funnel-shaped diverticulum that normally extends downward from the anterior aspect of the floor of the third ventricle into the infundibulum of the hypophysis; the embryonic structure gives rise the neural component of the pituitary (pas nervosa)" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent infundibular recess" EXACT []
synonym: "absent infundibular recess of 3rd ventricle" EXACT []
synonym: "absent recessus infundibularis" EXACT []
synonym: "absent recessus infundibuli" EXACT []
is_a: MP:0013489 ! abnormal infundibular recess of third ventricle morphology

[Term]
id: MP:0013491
name: abnormal Herring body morphology
def: "any structural anomaly of the dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary; Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release; each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively" [http://en.wikipedia.org/wiki/Herring_bodies, https://orcid.org/0000-0002-6490-7723, ISBN:0199652473]
synonym: "abnormal Herring bodies" EXACT []
synonym: "abnormal neurosecretory body morphology" EXACT []
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology

[Term]
id: MP:0013492
name: oral erythroplakia
def: "any lesion of the oral mucosa that presents as bright red plaques or macules with a soft and velvety texture and well-demarcated borders, commonly found in the floor of the mouth, buccal vestibule, the tongue, and the soft palate; an adjacent area of leukoplakia may be found along with the erythroplakia; although erythroplakia is much less common than leukoplakia, erythroplakia carries a significantly higher risk containing dysplasia or carcinoma in situ, and of eventually transforming into invasive squamous cell carcinoma (e.g. oral cancer)" [http://en.wikipedia.org/wiki/Erythroplakia, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003745 ! abnormal oral mucosa morphology

[Term]
id: MP:0013493
name: abnormal trachea submucosa morphology
def: "any structural anomaly of the loose fibrous connective tissue located under the tracheal mucosa and composed of abundant blood and lymphatic vessels, diffuse lymphatic tissue and lymphatic nodules, and seromucous tracheal glands; the submucosa ends with the perichondrium of the tracheal cartilages" [http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Respiratory/respir.htm, http://wwwmgs.bionet.nsc.ru/mgs/gnw/trrd/thesaurus/Re/trachea.html, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal tracheal submucosa morphology" EXACT []
synonym: "abnormal windpipe submucosa morphology" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0013494
name: abnormal trachea gland morphology
def: "any structural anomaly of the tubuloacinar seromucous glands located principally in the submucosa of the trachea whose excretory ducts pass through the lamina propria to the tracheal lumen; they secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents; in the mouse, they are restricted to the upper trachea, more specifically to the regions between the first few cartilage rings, with the precise distribution depending on genetic background" [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://orcid.org/0000-0002-6490-7723, ISBN:1451113412, PMID:15973734]
synonym: "abnormal glandula trachealis morphology" EXACT []
synonym: "abnormal glandulae tracheales morphology" EXACT []
synonym: "abnormal trachea submucosal gland morphology" EXACT []
synonym: "abnormal tracheal gland morphology" EXACT []
is_a: MP:0013493 ! abnormal trachea submucosa morphology
is_a: MP:0014033 ! abnormal submucosal gland morphology

[Term]
id: MP:0013495
name: decreased trachea gland number
def: "fewer than normal numbers of the tubuloacinar seromucous glands which are principally located in the submucosa of the trachea, open into the tracheal lumen through short ducts, and secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents; in the mouse, they are restricted to the upper trachea, more specifically to the regions between the first few cartilage rings, with the precise distribution depending on genetic background" [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://orcid.org/0000-0002-6490-7723, ISBN:1451113412, PMID:15973734]
synonym: "decreased glandula trachealis number" EXACT []
synonym: "decreased glandulae tracheales number" EXACT []
synonym: "decreased trachea submucosal gland number" EXACT []
synonym: "decreased tracheal gland number" EXACT []
synonym: "reduced glandula trachealis number" EXACT []
synonym: "reduced glandulae tracheales number" EXACT []
synonym: "reduced trachea submucosal gland number" EXACT []
synonym: "reduced tracheal gland number" EXACT []
is_a: MP:0013494 ! abnormal trachea gland morphology

[Term]
id: MP:0013496
name: abnormal trachea development
def: "aberrant formation or incomplete differentiation of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal tracheal development" EXACT []
synonym: "abnormal windpipe development" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0013497
name: trachea occlusion
def: "any impediment or blockage of the tube descending from the larynx and branching into the right and left main bronchi" [https://orcid.org/0000-0002-6490-7723]
synonym: "tracheal occlusion" EXACT []
synonym: "windpipe occlusion" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0013498
name: trachea inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the trachea" [https://orcid.org/0000-0002-6490-7723]
synonym: "tracheal inflammation" EXACT []
synonym: "tracheitis" EXACT []
is_a: MP:0002405 ! respiratory system inflammation

[Term]
id: MP:0013499
name: trachea fibrosis
def: "invasion of fibrous connective tissue into the trachea, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "tracheal fibrosis" EXACT []
is_a: MP:0002282 ! abnormal trachea morphology

[Term]
id: MP:0013500
name: abnormal fibroblast apoptosis
def: "change in the timing or the number of fibroblast cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0020414 ! abnormal fibroblast physiology

[Term]
id: MP:0013501
name: increased fibroblast apoptosis
def: "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0013500 ! abnormal fibroblast apoptosis

[Term]
id: MP:0013502
name: decreased fibroblast apoptosis
def: "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced fibroblast apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0013500 ! abnormal fibroblast apoptosis

[Term]
id: MP:0013503
name: abnormal embryonic tissue cell apoptosis
def: "change in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal embryo apoptosis" EXACT []
synonym: "abnormal embryo tissue cell apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0008932 ! abnormal embryonic tissue physiology

[Term]
id: MP:0013504
name: increased embryonic tissue cell apoptosis
def: "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased embryo apoptosis" EXACT []
synonym: "increased embryo tissue cell apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0013503 ! abnormal embryonic tissue cell apoptosis

[Term]
id: MP:0013505
name: decreased embryonic tissue cell apoptosis
def: "decrease in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased embryo apoptosis" EXACT []
synonym: "decreased embryo tissue cell apoptosis" EXACT []
synonym: "reduced embryo tissue cell apoptosis" EXACT []
synonym: "reduced embryonic tissue cell apoptosis" EXACT []
synonym: "reduced embyro apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0013503 ! abnormal embryonic tissue cell apoptosis

[Term]
id: MP:0013506
name: abnormal ovary apoptosis
def: "change in the timing or the number of cells in ovary tissue undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ovarian apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0003507 ! abnormal ovary physiology

[Term]
id: MP:0013507
name: increased ovary apoptosis
def: "increase in the number of ovary cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "elevated ovarian apoptosis" EXACT []
synonym: "elevated ovary apoptosis" EXACT []
synonym: "increased ovarian apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0013506 ! abnormal ovary apoptosis

[Term]
id: MP:0013508
name: increased granulosa cell apoptosis
def: "increase in the timing or the number of granulsa cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0013507 ! increased ovary apoptosis
is_a: MP:0031015 ! abnormal granulosa cell apoptosis

[Term]
id: MP:0013509
name: abnormal CD4-negative NK T cell number
def: "anomaly in the number of CD4-negative NK T cells" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008038 ! abnormal NK T cell number

[Term]
id: MP:0013510
name: decreased CD4-negative NK T cell number
def: "reduction in the number of CD4-negative NK T cells" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced CD4-negative NK T cell number" EXACT []
is_a: MP:0008040 ! decreased NK T cell number
is_a: MP:0013509 ! abnormal CD4-negative NK T cell number

[Term]
id: MP:0013511
name: increased CD4-negative NK T cell number
def: "increase in the number of CD4-negative NK T cells" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008039 ! increased NK T cell number
is_a: MP:0013509 ! abnormal CD4-negative NK T cell number

[Term]
id: MP:0013512
name: abnormal memory-marker CD4-negative NK T cell number
def: "anomaly in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013509 ! abnormal CD4-negative NK T cell number

[Term]
id: MP:0013513
name: decreased memory-marker CD4-negative NK T cell number
def: "reduction in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced memory-marker CD4-negative NK T cell number" EXACT []
is_a: MP:0013510 ! decreased CD4-negative NK T cell number
is_a: MP:0013512 ! abnormal memory-marker CD4-negative NK T cell number

[Term]
id: MP:0013514
name: increased memory-marker CD4-negative NK T cell number
def: "increase in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013511 ! increased CD4-negative NK T cell number
is_a: MP:0013512 ! abnormal memory-marker CD4-negative NK T cell number

[Term]
id: MP:0013515
name: abnormal KLRG1-positive CD4-negative NK T cell number
def: "anomaly in the number of KLRG1-positive CD4-negative NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013509 ! abnormal CD4-negative NK T cell number

[Term]
id: MP:0013516
name: decreased KLRG1-positive CD4-negative NK T cell number
def: "reduction in the number of KLRG1-positive CD4-negative NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced KLRG1-positive CD4-negative NK T cell number" EXACT []
is_a: MP:0013510 ! decreased CD4-negative NK T cell number
is_a: MP:0013515 ! abnormal KLRG1-positive CD4-negative NK T cell number

[Term]
id: MP:0013517
name: increased KLRG1-positive CD4-negative NK T cell number
def: "increase in the number of KLRG1-positive CD4-negative NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013511 ! increased CD4-negative NK T cell number
is_a: MP:0013515 ! abnormal KLRG1-positive CD4-negative NK T cell number

[Term]
id: MP:0013518
name: abnormal CD4-positive NK T cell number
def: "anomaly in the number of CD4-positive NK T cells" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008038 ! abnormal NK T cell number

[Term]
id: MP:0013519
name: decreased CD4-positive NK T cell number
def: "reduction in the number of CD4-positive NK T cells" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced CD4-positive NK T cell number" EXACT []
is_a: MP:0008040 ! decreased NK T cell number
is_a: MP:0013518 ! abnormal CD4-positive NK T cell number

[Term]
id: MP:0013520
name: increased CD4-positive NK T cell number
def: "increase in the number of CD4-positive NK T cells" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008039 ! increased NK T cell number
is_a: MP:0013518 ! abnormal CD4-positive NK T cell number

[Term]
id: MP:0013521
name: abnormal memory-marker CD4-positive NK T cell number
def: "anomaly in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013518 ! abnormal CD4-positive NK T cell number

[Term]
id: MP:0013522
name: decreased memory-marker CD4-positive NK T cell number
def: "reduction in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced memory-marker CD4-positive NK T cell number" EXACT []
is_a: MP:0013519 ! decreased CD4-positive NK T cell number
is_a: MP:0013521 ! abnormal memory-marker CD4-positive NK T cell number

[Term]
id: MP:0013523
name: increased memory-marker CD4-positive NK T cell number
def: "increase in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013520 ! increased CD4-positive NK T cell number
is_a: MP:0013521 ! abnormal memory-marker CD4-positive NK T cell number

[Term]
id: MP:0013524
name: abnormal KLRG1-positive CD4-positive NK T cell number
def: "anomaly in the number of KLRG1-positive CD4-positive NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013518 ! abnormal CD4-positive NK T cell number

[Term]
id: MP:0013525
name: decreased KLRG1-positive CD4-positive NK T cell number
def: "reduction in the number of KLRG1-positive CD4-positive NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced KLRG1-positive CD4-positive NK T cell number" EXACT []
is_a: MP:0013519 ! decreased CD4-positive NK T cell number
is_a: MP:0013524 ! abnormal KLRG1-positive CD4-positive NK T cell number

[Term]
id: MP:0013526
name: increased KLRG1-positive CD4-positive NK T cell number
def: "increase in the number of KLRG1-positive CD4-positive NK T cells, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013520 ! increased CD4-positive NK T cell number
is_a: MP:0013524 ! abnormal KLRG1-positive CD4-positive NK T cell number

[Term]
id: MP:0013527
name: absent conjunctiva goblet cells
def: "absence or failure to develop the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent conjunctival goblet cells" EXACT []
is_a: MP:0013464 ! decreased conjunctiva goblet cell number

[Term]
id: MP:0013528
name: thyroid gland cyst
def: "presence of one or more fluid-filled cavities (cysts) in the thyroid commonly resulting from degenerating thyroid adenomas; thyroid cysts are usually benign, but they occasionally contain malignant solid components" [http://www.mayoclinic.org/diseases-conditions/thyroid-nodules/basics/causes/con-20021546, https://orcid.org/0000-0002-6490-7723]
synonym: "cystic thyroid gland" EXACT []
synonym: "thyroid cyst" EXACT []
synonym: "thyroid cysts" EXACT []
synonym: "thyroid gland cysts" EXACT []
is_a: MP:0000681 ! abnormal thyroid gland morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0013529
name: decreased nipple number
def: "fewer than the expected number of structures located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open; normal female mice have five pairs of mammary glands and nipples (males have no nipples); two pairs of nipples are situated in the abdomino-inguinal region (inguinal group) and three pairs in the ventral thoracic region (pectoral or thoracic group)" [http://www.informatics.jax.org/cookbook/figures/figure48.shtml, http://www.informatics.jax.org/cookbook/figures/figure50.shtml, https://orcid.org/0000-0002-6490-7723]
comment: Variation in number and arrangement of nipples is frequent on some mouse strains. For examples, fewer than five pairs are common in strain A females; more than five pairs in BALB/c females (Little, C.C., and H. MacDonald. 1945. Abnormalities of the mammae in the house mouse. J. Hered. 36: 285-288.)
synonym: "decreased papilla mammae number" EXACT []
synonym: "decreased teat number" EXACT []
synonym: "decreased thele mammae number" EXACT []
synonym: "decreased thelium mammae number" EXACT []
synonym: "reduced nipple number" EXACT []
synonym: "reduced papilla mammae number" EXACT []
synonym: "reduced teat number" EXACT []
synonym: "reduced thele number" EXACT []
synonym: "reduced thelium number" EXACT []
is_a: MP:0006078 ! abnormal nipple morphology

[Term]
id: MP:0013530
name: abnormal periderm morphology
def: "any structural anomaly of the outermost layer of the bilaminar embryonic/fetal epidermis, the first non-basal layer formed at approximately E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at approximately E17, when it is replaced by corneocytes; desquamated peridermal cells are a considerable component of the vernix caseosa, a white, cheesy, protective substance that covers the fetal skin" [http://discovery.lifemapsc.com/in-vivo-development/epidermis#section_literature, http://medical-dictionary.thefreedictionary.com/periderm, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal epitrichium morphology" EXACT []
is_a: MP:0012532 ! abnormal surface ectoderm morphology

[Term]
id: MP:0013531
name: abnormal periderm development
def: "abnormal formation of the outermost layer of the bilaminar embryonic/fetal epidermis; periderm cells emerge at approximately E9.5 and form simple squamous epithelium, the most superficial embryonic layer; these cells form the first, but temporary, embryonic permeability barrier, and are replaced by the cornified envelope, that forms during keratinocyte stratification, by E16.5" [http://discovery.lifemapsc.com/in-vivo-development/epidermis/embryonic-epidermis/periderm-cells, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal epitrichium development" EXACT []
is_a: MP:0013530 ! abnormal periderm morphology

[Term]
id: MP:0013532
name: abnormal parotid gland physiology
def: "any functional anomaly of either of the largest of the major salivary glands situated below and in front of each ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal external salivary gland physiology" EXACT []
synonym: "abnormal glandula parotidea physiology" EXACT []
synonym: "abnormal glandula parotis physiology" EXACT []
synonym: "abnormal parotid gland function" EXACT []
synonym: "abnormal parotid physiology" EXACT []
is_a: MP:0013534 ! abnormal major salivary gland physiology

[Term]
id: MP:0013533
name: sublingual gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in either of the small mucin-producing salivary glands located in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "Rivinus gland inflammation" EXACT []
synonym: "sublingual sialadenitis" EXACT []
synonym: "sublingual sialoadenitis" EXACT []
is_a: MP:0001870 ! salivary gland inflammation
is_a: MP:0013536 ! abnormal sublingual gland physiology

[Term]
id: MP:0013534
name: abnormal major salivary gland physiology
def: "any functional anomaly of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0005310 ! abnormal salivary gland physiology

[Term]
id: MP:0013535
name: abnormal minor salivary gland physiology
def: "any functional anomaly of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005310 ! abnormal salivary gland physiology

[Term]
id: MP:0013536
name: abnormal sublingual gland physiology
def: "any functional anomaly of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Rivinus gland physiology" EXACT []
is_a: MP:0013534 ! abnormal major salivary gland physiology

[Term]
id: MP:0013537
name: increased salivary gland adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any salivary gland, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "salivary adenoma" RELATED []
is_a: MP:0010318 ! increased salivary gland tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0013538
name: increased Harderian gland adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the Harderian gland, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "Harderian gland adenoma" RELATED []
is_a: MP:0010383 ! increased adenoma incidence
is_a: MP:0012437 ! increased Harderian gland tumor incidence

[Term]
id: MP:0013539
name: increased ovary adenoma incidence
def: "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the ovary, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "ovarian adenoma" RELATED []
is_a: MP:0008000 ! increased ovary tumor incidence
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0013540
name: increased submandibular gland apoptosis
def: "increase in the number of cells of the submandibular gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased maxillary gland apoptosis" EXACT []
synonym: "increased submaxillary gland apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0013300 ! abnormal submandibular gland physiology

[Term]
id: MP:0013541
name: abnormal submandibular gland development
def: "aberrant formation or incomplete differentiation of either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible; in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty" [https://orcid.org/0000-0002-6490-7723, PMID:17336109]
synonym: "abnormal maxillary gland development" EXACT []
synonym: "abnormal submaxillary gland development" EXACT []
is_a: MP:0003793 ! abnormal submandibular gland morphology

[Term]
id: MP:0013542
name: abnormal submandibular gland branching morphogenesis
def: "anomaly in the process in which the branching structure of the submandibular gland is generated and organized" [GO:1990632]
synonym: "abnormal branching involved in submandibular gland morphogenesis" EXACT []
synonym: "abnormal submandibular gland ductal branching" EXACT []
is_a: MP:0013541 ! abnormal submandibular gland development

[Term]
id: MP:0013543
name: abnormal holocrine gland morphology
def: "any structural anomaly of any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen" [http://en.wikipedia.org/wiki/Holocrine, http://medical-dictionary.thefreedictionary.com/holocrine+gland, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0013544
name: abnormal merocrine gland morphology
def: "any structural anomaly of any exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged" [http://en.wikipedia.org/wiki/Merocrine, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eccrine gland morphology" EXACT []
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0013545
name: cleft hard palate
def: "cleft in the anterior portion of the palate consisting of bone and mucous membranes; the hard palate is formed from bony processes of the maxilla, premaxilla and palatine bones" [UBERON:0003216]
is_a: MP:0003756 ! abnormal hard palate morphology
is_a: MP:0009890 ! cleft secondary palate

[Term]
id: MP:0013546
name: cleft soft palate
def: "a cleft in the soft tissue constituting the back of the roof of the mouth; the soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate to the back of the mouth" [UBERON:0001733]
is_a: MP:0003154 ! abnormal soft palate morphology
is_a: MP:0009890 ! cleft secondary palate

[Term]
id: MP:0013547
name: submucous cleft soft palate
def: "a cleft of the soft palate which is characterized by a midline deficiency or lack of muscular tissue and incorrect positioning of the muscles, but cleft is covered over by the mucous membrane of the roof of the mouth; frequently associated with a bifid or cleft uvula" [https://live-acpa.pantheonsite.io/wp-content/uploads/2023/01/ACPA_booklet_Submucous.pdf]
is_a: MP:0011615 ! submucous cleft palate
is_a: MP:0013546 ! cleft soft palate

[Term]
id: MP:0013548
name: submucous cleft hard palate
def: "a cleft of the hard palate characterized by a bony defect in the midline or center of the bony part of the palate, but cleft is covered over by the mucous membrane of the roof of the mouth" [https://live-acpa.pantheonsite.io/wp-content/uploads/2023/01/ACPA_booklet_Submucous.pdf]
is_a: MP:0011615 ! submucous cleft palate
is_a: MP:0013545 ! cleft hard palate

[Term]
id: MP:0013549
name: abnormal primary palate morphology
def: "any structural anomaly of the tissues normally uniting to form the primary palate; the primary palate will form the premaxillary portion of the maxilla (anterior one-third of the final palate)" [PMID:16680722]
synonym: "abnormal primitive palate morphology" EXACT []
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0013550
name: abnormal secondary palate morphology
def: "any structural anomaly of the portion of the palate formed by the growth of the two palatine shelves medially and their mutual fusion in the midline" [https://en.wikipedia.org/wiki/Secondary_palate]
synonym: "abnormal definitive palate morphology" EXACT []
is_a: MP:0003755 ! abnormal palate morphology

[Term]
id: MP:0013551
name: decreased cerebellar granule cell precursor proliferation
def: "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced cerebellar granule precursor cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009968 ! abnormal cerebellar granule cell precursor proliferation

[Term]
id: MP:0013552
name: increased cerebellar granule cell precursor proliferation
def: "increase in the ability of a cerebellar granule precursor cell population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0009968 ! abnormal cerebellar granule cell precursor proliferation

[Term]
id: MP:0013553
name: increased macrophage proliferation
def: "increased ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0011985 ! abnormal macrophage proliferation

[Term]
id: MP:0013554
name: abnormal apocrine gland morphology
def: "any structural anomaly of any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk" [http://en.wikipedia.org/wiki/Apocrine, https://orcid.org/0000-0002-6490-7723, ISBN:0123813611]
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0013555
name: abnormal apocrine gland physiology
def: "any functional anomaly of any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk" [http://en.wikipedia.org/wiki/Apocrine, https://orcid.org/0000-0002-6490-7723, ISBN:0123813611]
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0013556
name: abnormal holocrine gland physiology
def: "any functional anomaly of any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen" [http://en.wikipedia.org/wiki/Holocrine, http://medical-dictionary.thefreedictionary.com/holocrine+gland, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0013557
name: abnormal merocrine gland physiology
def: "any functional anomaly of any exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged" [http://en.wikipedia.org/wiki/Merocrine, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eccrine gland physiology" EXACT []
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0013558
name: abnormal exocrine gland morphology
def: "any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal duct gland morphology" EXACT []
synonym: "abnormal ducted gland morphology" EXACT []
synonym: "abnormal glandula exocrine morphology" EXACT []
is_a: MP:0002163 ! abnormal gland morphology

[Term]
id: MP:0013559
name: abnormal exocrine gland physiology
def: "any functional anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal duct gland physiology" EXACT []
synonym: "abnormal ducted gland physiology" EXACT []
synonym: "abnormal glandula exocrine physiology" EXACT []
is_a: MP:0002164 ! abnormal gland physiology

[Term]
id: MP:0013560
name: abnormal endocrine gland morphology
def: "any structural anomaly of any of the glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct" [UBERON:0002368]
synonym: "abnormal ductless gland morphology" EXACT []
synonym: "abnormal glandula endocrina morphology" EXACT []
is_a: MP:0002163 ! abnormal gland morphology

[Term]
id: MP:0013561
name: abnormal endocrine gland physiology
def: "any functional anomaly of any of the glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct" [https://orcid.org/0000-0002-6490-7723, UBERON:0002368]
synonym: "abnormal ductless gland physiology" EXACT []
synonym: "abnormal glandula endocrina physiology" EXACT []
is_a: MP:0002164 ! abnormal gland physiology

[Term]
id: MP:0013562
name: abnormal circumventricular organ morphology
def: "any structural abnormality of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow; CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances" [http://en.wikipedia.org/wiki/Circumventricular_organs, UBERON:0005408]
synonym: "abnormal circumventricular organ of neuraxis morphology" EXACT []
synonym: "abnormal CVO morphology" EXACT []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0013563
name: abnormal secretory circumventricular organ morphology
def: "any structural abnormality of any of the circumventricular organs that are responsible for secreting hormones and glycoproteins into the peripheral vascular system using feedback from both the brain environment and external stimuli" [http://en.wikipedia.org/wiki/Circumventricular_organs]
synonym: "abnormal secretory CVO morphology" EXACT []
is_a: MP:0000631 ! abnormal neuroendocrine gland morphology
is_a: MP:0013562 ! abnormal circumventricular organ morphology

[Term]
id: MP:0013564
name: abnormal sensory circumventricular organ morphology
def: "any structural anomaly of any of the circumventricular organs that have the ability to sense plasma molecules and then pass that information into other regions of the brain, thereby providing direct information to the autonomic nervous system from systemic circulation" [http://en.wikipedia.org/wiki/Circumventricular_organs]
synonym: "abnormal sensory CVO morphology" EXACT []
is_a: MP:0013562 ! abnormal circumventricular organ morphology

[Term]
id: MP:0013565
name: abnormal adrenal gland capsule morphology
def: "any structural anomaly of the thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex" [https://orcid.org/0000-0002-6490-7723, ISBN:1581124686]
synonym: "abnormal suprarenal capsule morphology" EXACT []
is_a: MP:0000639 ! abnormal adrenal gland morphology

[Term]
id: MP:0013566
name: dilated gastric gland
def: "stretched or widened aperture of the luminal space of one or more of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated fundic gland" EXACT []
synonym: "dilated fundic glands" EXACT []
synonym: "dilated fundus gland" EXACT []
synonym: "dilated fundus glands" EXACT []
synonym: "dilated gastric follicle" EXACT []
synonym: "dilated gastric follicles" EXACT []
synonym: "dilated gastric glands" EXACT []
synonym: "dilated oxyntic gland" EXACT []
synonym: "dilated oxyntic glands" EXACT []
synonym: "dilated Wassmann gland" EXACT []
synonym: "dilated Wassmann glands" EXACT []
synonym: "fundic gland dilation" EXACT []
synonym: "fundus gland dilation" EXACT []
synonym: "gastric follicle dilation" EXACT []
synonym: "oxyntic gland dilation" EXACT []
synonym: "Wassmann gland dilation" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0013567
name: gastric gland atrophy
def: "acquired diminution of the size of any of the gastric glands, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [https://orcid.org/0000-0002-6490-7723]
synonym: "fundic gland atrophy" EXACT []
synonym: "fundus gland atrophy" EXACT []
synonym: "gastric follicle atrophy" EXACT []
synonym: "oxyntic gland atrophy" EXACT []
synonym: "Wassmann gland atrophy" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0013568
name: gastric gland degeneration
def: "a retrogressive impairment of function or destruction of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [https://orcid.org/0000-0002-6490-7723]
synonym: "fundic gland degeneration" EXACT []
synonym: "fundus gland degeneration" EXACT []
synonym: "gastric follicle degeneration" EXACT []
synonym: "oxyntic gland degeneration" EXACT []
synonym: "Wassmann gland degeneration" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0013569
name: gastric gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the gastric gland, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "fundic gland hyperplasia" EXACT []
synonym: "fundus gland hyperplasia" EXACT []
synonym: "gastric follicle hyperplasia" EXACT []
synonym: "oxyntic gland hyperplasia" EXACT []
synonym: "Wassmann gland hyperplasia" EXACT []
is_a: MP:0003892 ! abnormal gastric gland morphology

[Term]
id: MP:0013570
name: abnormal neuroendocrine gland physiology
def: "any functional anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli" [ISBN:0-683-40008-8]
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0013561 ! abnormal endocrine gland physiology

[Term]
id: MP:0013571
name: abnormal parathyroid gland capsule morphology
def: "any structural anomaly of the dense and irregular connective tissue capsule surrounding each parathyroid gland" [http://www.pathwaymedicine.org/parathyroid-gland-histology, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0013572
name: abnormal parathyroid gland chief cell morphology
def: "any structural anomaly of an epithelial cell that are collectively arranged in wide, irregular interconnecting columns in the parathyroid gland, that is responsible for the synthesis and secretion of parathyroid hormone (PTH)" [CL:0000446, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal chief cell morphology" BROAD []
synonym: "abnormal chief cell of parathyroid gland morphology" EXACT []
synonym: "abnormal parathyroid chief cell morphology" EXACT []
synonym: "abnormal parathyroid gland principal cell morphology" EXACT []
synonym: "abnormal parathyroid hormone secreting cell morphology" EXACT []
synonym: "abnormal parathyroid principal cell morphology" EXACT []
synonym: "abnormal principal cell of parathyroid gland morphology" EXACT []
synonym: "abnormal PTH secreting cell morphology" EXACT []
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0013573
name: abnormal parathyroid gland development
def: "aberrant formation or incomplete differentiation of either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH), a hormone that regulates calcium and phosphorous metabolism; in mouse, the parathyroids develop with the thymus from two common parathyroid/thymus primordia originating from the third pharyngeal pouch endoderm; the third pharyngeal pouches are formed at E9.5-E10 and are patterned into dorsal/anterior parathyroid and ventral/posterior thymus domains; the third pouch endoderm proliferates to form bilateral parathyroid/thymus common primordia at E11-E11.5; each primordium separates into one parathyroid gland and one thymus lobe at E12.5-E13.5, which then migrate to their eventual adult locations by about E14.5; in the adult mouse, the parathyroids are located near or embedded within the thyroid gland, and the thymus is situated in the anterior chest cavity" [https://orcid.org/0000-0002-6490-7723, PMID:17382312]
is_a: MP:0000678 ! abnormal parathyroid gland morphology
is_a: MP:0020973 ! abnormal gland development

[Term]
id: MP:0013574
name: ectopic parathyroid gland
def: "a parathyroid gland located outside of its normal position; in the normal adult mouse, the parathyroids are usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; because of their common pharyngeal pouch origin, ectopic thyroid and parathyroid tissue can occasionally be found in the thymus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000678 ! abnormal parathyroid gland morphology

[Term]
id: MP:0013575
name: abnormal forestomach-glandular stomach junction morphology
def: "any structural anomaly of the distinct low fold of tissue that separates the non-glandular area of the stomach (forestomach) from the glandular stomach; the limiting ridge extends circumferentially from the large curvature of the stomach to the small curvature, just below the esophagus; at the esophagus, the course of the limiting ridge bends into a U-shape and almost surrounds the esophageal opening" [http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CCUQFjAB&url=http%3A%2F%2Fjournals.usamvcluj.ro%2Findex.php%2Fveterinary%2Farticle%2Fdownload%2F5889%2F5384&ei=nQ61VJvFEMuQyASZpYGgCw&usg=AFQjCNHtPvbkRJR7v3Jh2Ht2z-s9qVBLGA&bvm=bv.83339334\,d.aWw&cad=rja, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal forestomach - glandular stomach squamocolumnar junction morphology" EXACT []
synonym: "abnormal limiting ridge of stomach morphology" EXACT []
synonym: "abnormal margo plicatus morphology" EXACT []
synonym: "abnormal squamo-columnar junction between forestomach and glandular stomach morphology" EXACT []
synonym: "abnormal squamocolumnar junction with the glandular stomach morphology" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0013576
name: small forestomach
def: "reduced size of the distinct rodent non-glandular region of the stomach which is demarcated from the glandular stomach by the limiting ridge (margo plicatus)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased non-glandular stomach size" EXACT []
synonym: "reduced forstomach size" EXACT []
synonym: "reduced non-glandular stomach size" EXACT []
synonym: "small anterior stomach" EXACT []
synonym: "small antrum cardiacum" EXACT []
synonym: "small non-glandular stomach" EXACT []
synonym: "small proximal stomach" EXACT []
synonym: "small stomach non-glandular region" EXACT []
is_a: MP:0010784 ! abnormal forestomach morphology

[Term]
id: MP:0013577
name: forestomach hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the forestomach, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "anterior stomach hypoplasia" EXACT []
synonym: "antrum cardiacum hypoplasia" EXACT []
synonym: "hypoplastic forestomach" EXACT []
synonym: "non-glandular stomach hypoplasia" EXACT []
synonym: "proximal stomach hypoplasia" EXACT []
synonym: "stomach non-glandular region hypoplasia" EXACT []
is_a: MP:0013576 ! small forestomach

[Term]
id: MP:0013578
name: abnormal stomach glandular region morphology
def: "any structural anomaly of the distinct glandular stomach area which in rodents is demarcated from the non-glandular forestomach by the limiting ridge (margo plicatus); the glandular stomach is connected to the small intestine (duodenum); the wall of the glandular stomach consists of, from inside to outside, simple columnar epithelium containing gastric glands, the lamina propria (epithelium and lamina propria form the glandular mucosa), the muscularis mucosae, the submucosa, the muscularis interna and externa (inner circular and outer longitudinal layers of smooth muscle), and the serosa; the gastric glands lined by simple columnar epithelium form deep gastric pits (foveolae) that are perpendicular to the wall of the stomach; three types of gastric glands exist; the cardiac glands, located near the limiting ridge, contain mucous cells; the pyloric glands also contain mucous cells; the fundic glands, which make up the majority of the gastric glands, contain a variety of cells: mucous neck cells, small, basophilic chief cells, and large, round parietal cells with a granular eosinophilic cytoplasm" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/glandular.html, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glandular stomach morphology" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0013579
name: increased adrenal gland apoptosis
def: "increase in the number of any cells of the adrenal gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased suprarenal gland apoptosis" EXACT []
is_a: MP:0002909 ! abnormal adrenal gland physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0013580
name: abnormal nasal gland morphology
def: "any structural anomaly of any of the seromucous glands found in the respiratory region of the nasal mucous membrane, including anterior serous glands, seromucous glands, and Bowman glands" [http://en.wikipedia.org/wiki/Nasal_glands, https://orcid.org/0000-0002-6490-7723, UBERON:0012278]
synonym: "abnormal gland of nasal mucosa morphology" EXACT []
synonym: "abnormal glandula nasalis morphology" EXACT []
synonym: "abnormal glandulae nasales morphology" EXACT []
is_a: MP:0002238 ! abnormal nasal mucosa morphology
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0013581
name: nasal gland degeneration
def: "a retrogressive impairment of function or destruction of any of the seromucous glands found in the respiratory region of the nasal mucous membrane" [http://en.wikipedia.org/wiki/Nasal_glands, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013580 ! abnormal nasal gland morphology

[Term]
id: MP:0013582
name: abnormal lateral nasal gland morphology
def: "any structural anomaly of the lateral nasal glands (the largest nasal secretory glands in rodents) which surround the maxillary sinus located in the lateral wall adjacent to each nasal passage and are characterized by cytologic features similar to those described for the major serous salivary glands; secretory contents of the LNG drain into the nasal vestibule; the LNG is a major site for the synthesis and secretion of odorant-binding proteins that serve as odorant carriers in nasal mucus; it also, synthesizes large amounts of immunoglobulin A, which is important for immune defense of the upper respiratory tract, and testosterone and salivary androgen-binding proteins, which are likely important in olfaction and reproductive behavior" [https://orcid.org/0000-0002-6490-7723, ISBN:0080454321, ISBN:0123813611]
synonym: "abnormal glandula nasalis lateralis morphology" EXACT []
synonym: "abnormal LNG morphology" EXACT []
synonym: "abnormal Steno gland morphology" EXACT []
synonym: "abnormal Steno's gland morphology" EXACT []
is_a: MP:0013580 ! abnormal nasal gland morphology

[Term]
id: MP:0013583
name: salivary gland degeneration
def: "a retrogressive impairment of function or destruction of any of the saliva-secreting glands of the oral cavity" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000613 ! abnormal salivary gland morphology

[Term]
id: MP:0013584
name: pancreas degeneration
def: "a retrogressive impairment of function or destruction of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0013585
name: thymus cortex atrophy
def: "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic thymic cortex" EXACT []
synonym: "atrophic thymus cortex" EXACT []
synonym: "thymic cortex atrophy" EXACT []
is_a: MP:0002371 ! abnormal thymus cortex morphology
is_a: MP:0003644 ! thymus atrophy

[Term]
id: MP:0013586
name: thymus medulla atrophy
def: "acquired diminution of the inner area of thymus lobules associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic thymic medulla" EXACT []
synonym: "atrophic thymus medulla" EXACT []
synonym: "thymic medulla atrophy" EXACT []
is_a: MP:0002375 ! abnormal thymus medulla morphology
is_a: MP:0003644 ! thymus atrophy

[Term]
id: MP:0013587
name: absent thymus medulla
def: "lacking the inner area of thymus lobules" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent thymic medulla" EXACT []
is_a: MP:0002375 ! abnormal thymus medulla morphology

[Term]
id: MP:0013588
name: small thymus medulla
def: "decreased size of the inner area of thymus lobules" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased thymic medulla area" EXACT []
synonym: "decreased thymus medulla area" EXACT []
synonym: "reduced thymic medulla area" EXACT []
synonym: "reduced thymus medulla area" EXACT []
is_a: MP:0002375 ! abnormal thymus medulla morphology

[Term]
id: MP:0013589
name: thymus medulla hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the thymus medulla, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cellularity of thymic medulla" EXACT []
synonym: "decreased thymic medulla cellularity" EXACT []
synonym: "hypoplasia of thymic medulla" EXACT []
synonym: "hypoplastic thymus medulla" EXACT []
synonym: "thymic medulla hypoplasia" EXACT []
is_a: MP:0013588 ! small thymus medulla

[Term]
id: MP:0013590
name: enlarged thymus medulla
def: "increased size of the inner area of thymus lobules" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased thymic medulla area" EXACT []
synonym: "increased thymic medulla size" EXACT []
synonym: "increased thymus medulla area" EXACT []
synonym: "increased thymus medulla size" EXACT []
is_a: MP:0002375 ! abnormal thymus medulla morphology

[Term]
id: MP:0013591
name: thymus medulla hyperplasia
def: "increase in the number of normal cells in normal arrangement in the thymus medulla, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplasia of thymic medulla" EXACT []
synonym: "hyperplastic thymus medulla" EXACT []
synonym: "increased cellularity of thymic medulla" EXACT []
synonym: "increased thymic medulla cellularity" EXACT []
synonym: "thymic medulla hyperplasia" EXACT []
is_a: MP:0013590 ! enlarged thymus medulla

[Term]
id: MP:0013592
name: small thymus cortex
def: "decreased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased thymic cortex area" EXACT []
synonym: "decreased thymic cortex size" EXACT []
synonym: "decreased thymus cortex area" EXACT []
synonym: "decreased thymus cortex size" EXACT []
synonym: "reduced thymic cortex area" EXACT []
synonym: "reduced thymic cortex size" EXACT []
synonym: "reduced thymus cortex area" EXACT []
synonym: "reduced thymus cortex size" EXACT []
is_a: MP:0002371 ! abnormal thymus cortex morphology

[Term]
id: MP:0013593
name: enlarged thymus cortex
def: "increased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "increased thymic cortex area" EXACT []
synonym: "increased thymic cortex size" EXACT []
synonym: "increased thymus cortex area" EXACT []
synonym: "increased thymus cortex size" EXACT []
is_a: MP:0002371 ! abnormal thymus cortex morphology

[Term]
id: MP:0013594
name: abnormal parotid gland acinus morphology
def: "any structural anomaly of any of the secretory units (acini) of either parotid gland which in human and rodent consist almost exclusively of serous secretory cells with their lumina continuous with intercalated ducts; in mouse, parotid gland acini are very small and consist of 3-4 tall pyramidal cells with strongly basophilic cytoplasm and basally located, large spherical nuclei; the serous secretory cells contain many secretory granules having an electron-lucent profile which are situated in the supranuclear cytoplasm; the serous secretory cells have a well-developed rough endoplasmic reticulum in the infranuclear region and are surrounded by myoepithelial cells" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, https://orcid.org/0000-0002-6490-7723, PMID:23209333]
is_a: MP:0003452 ! abnormal parotid gland morphology

[Term]
id: MP:0013595
name: absent vomeronasal organ
def: "lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [https://orcid.org/0000-0003-3691-0324]
comment: Note that this structure is normally absent in adult higher primates as well as a number of other species.
synonym: "absent Jacobson organ" EXACT []
synonym: "absent Jacobson's organ" EXACT []
synonym: "absent organon vomeronasale" EXACT []
synonym: "absent organum vomeronasale" EXACT []
synonym: "absent VNO" EXACT []
is_a: MP:0002243 ! abnormal vomeronasal organ morphology

[Term]
id: MP:0013596
name: abnormal vomeronasal organ physiology
def: "any functional anomaly of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system; the organ lies at the base the nasal cavity and is split into two, separated by the nasal septum" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal Jacobson organ physiology" EXACT []
synonym: "abnormal Jacobson's organ physiology" EXACT []
synonym: "abnormal organon vomeronasale physiology" EXACT []
synonym: "abnormal organum vomeronasale physiology" EXACT []
synonym: "abnormal VNO physiology" EXACT []
is_a: MP:0005423 ! abnormal somatic nervous system physiology

[Term]
id: MP:0013597
name: small vomeronasal organ
def: "reduced size of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased Jacobson organ size" EXACT []
synonym: "decreased Jacobson's organ size" EXACT []
synonym: "decreased organon vomeronasale size" EXACT []
synonym: "decreased organum vomeronasale size" EXACT []
synonym: "decreased VNO size" EXACT []
synonym: "decreased vomeronasal organ size" EXACT []
synonym: "reduced Jacobson organ size" EXACT []
synonym: "reduced Jacobson's organ size" EXACT []
synonym: "reduced organon vomeronasale size" EXACT []
synonym: "reduced organum vomeronasale size" EXACT []
synonym: "reduced VNO size" EXACT []
synonym: "reduced vomeronasal organ size" EXACT []
synonym: "small Jacobson organ" EXACT []
synonym: "small Jacobson's organ" EXACT []
synonym: "small organon vomeronasale" EXACT []
synonym: "small organum vomeronasale" EXACT []
synonym: "small VNO" EXACT []
is_a: MP:0002243 ! abnormal vomeronasal organ morphology

[Term]
id: MP:0013598
name: Leydig cell hypertrophy
def: "increased size of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH)" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged Leydig cells" EXACT []
synonym: "hypertrophic Leydig cells" EXACT []
synonym: "increased Leydig cell size" BROAD []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0013599
name: Leydig cell atrophy
def: "acquired diminution of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH), associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic Leydig cells" EXACT []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0013600
name: testis degeneration
def: "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [https://orcid.org/0000-0002-6490-7723]
synonym: "testicular degeneration" EXACT []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0013601
name: increased testis apoptosis
def: "increase in the number of cells in testicular tissue undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased testicular apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0031353 ! abnormal testis apoptosis

[Term]
id: MP:0013602
name: abnormal Leydig cell differentiation
def: "atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal LC differentiation" EXACT []
is_a: MP:0002786 ! abnormal Leydig cell morphology

[Term]
id: MP:0013603
name: abnormal fetal Leydig cell differentiation
def: "atypical formation of or inability to produce the first or fetal population of Leydig cells (FLCs); in mice, FLCs arise in the testicular interstitium between E12.5 and E13.0, approximately 1 day after the appearance of Sertoli cells; Sertoli cells trigger differentiation of steroidogenic factor 1-positive (SF1-positive) progenitor cells into FLCs via paracrine regulation; the intercellular Notch signaling pathway is also involved in FLC establishment and maintenance; the FLC population increases dramatically during embryonic development despite the fact that differentiating FLCs are mitotically inactive, suggesting that expansion of FLC populations results from differentiation of progenitor cells, rather than cell division of existing FLCs; the SF1-positive cells in gonadal primordia are the primary source of FLCs but other sources such as neighboring mesonephros, migrating neural crest cells, and cells from the coelomic epithelium or interstitium are potential contributors also; at the end of fetal life and during the first 2 postnatal weeks in rodents, FLCs are gradually replaced by adult Leydig cells (ALCs)" [PMID:23568777]
synonym: "abnormal FLC differentiation" EXACT []
synonym: "abnormal foetal Leydig cell differentiation" EXACT []
is_a: MP:0013602 ! abnormal Leydig cell differentiation

[Term]
id: MP:0013604
name: abnormal adult Leydig cell differentiation
def: "atypical formation of or inability to produce the second or adult population of Leydig cells (ALCs) between birth and puberty; ALCs arise in the interstitium of adult testes from unknown progenitor cells and become the major source of androgens that control differentiation of the male reproductive tract and spermatogenesis; ALCs are not derived from fetal Leydig cells (FLCs), and the origin and the molecular events that control ALC differentiation are poorly understood" [PMID:23568777]
is_a: MP:0013602 ! abnormal Leydig cell differentiation

[Term]
id: MP:0013605
name: abnormal ovarian bursa morphology
def: "any structural anomaly of the peritoneal recess between the medial aspect of the ovary and the mesosalpinx" [https://orcid.org/0000-0002-6490-7723, UBERON:0012333]
synonym: "abnormal bursa ovarica morphology" EXACT []
is_a: MP:0009216 ! abnormal peritoneum morphology

[Term]
id: MP:0013606
name: abnormal ovarian fossa morphology
def: "any structural anomaly of the shallow depression in the parietal peritoneum of the pelvis that lodges the ovary" [https://orcid.org/0000-0003-3691-0324, ISBN:068340007X]
synonym: "abnormal Claudius fossa morphology" EXACT []
synonym: "abnormal fossa ovarica morphology" EXACT []
is_a: MP:0009216 ! abnormal peritoneum morphology

[Term]
id: MP:0013607
name: ovary fibrosis
def: "invasion of fibrous connective tissue into the ovary, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "fibrotic ovaries" EXACT []
synonym: "fibrotic ovary" EXACT []
synonym: "ovarian fibrosis" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013608
name: abnormal ovarian cortex morphology
def: "any structural anomaly of the layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles" [http://en.wikipedia.org/wiki/Ovary, http://medical-dictionary.thefreedictionary.com/cortex+of+ovary]
synonym: "abnormal cortex of ovary morphology" EXACT []
synonym: "abnormal cortex ovarii (zona parenchymatosa) morphology" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013609
name: abnormal ovarian medulla morphology
def: "any structural anomaly of the highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter" [http://en.wikipedia.org/wiki/Ovary, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal medulla of ovary morphology" EXACT []
synonym: "abnormal medulla ovarii (zona vasculosa) morphology" EXACT []
synonym: "abnormal zona vasculosa of Waldeyer morphology" EXACT []
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013610
name: abnormal rete ovarii morphology
def: "any structural anomaly of the canal structure formed from the primary sex cords in females; a transient network of cells in the developing ovary that is homologous to the rete testis in males" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0013611
name: abnormal bile duct epithelium morphology
def: "any structural anomaly of the epithelium lining the intrahepatic and extrahepatic bile ducts" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bile duct epithelial tissue morphology" EXACT []
synonym: "abnormal biliary duct epithelial tissue morphology" EXACT []
synonym: "abnormal biliary duct epithelium morphology" EXACT []
synonym: "abnormal biliary epithelium morphology" EXACT []
synonym: "abnormal epithelial tissue of bile duct morphology" EXACT []
synonym: "abnormal epithelial tissue of biliary duct morphology" EXACT []
synonym: "abnormal epithelium of bile duct morphology" EXACT []
synonym: "abnormal epithelium of biliary duct morphology" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology

[Term]
id: MP:0013612
name: enlarged caudal vertebrae
def: "increased size of the bony segments of the coccyx or tail" [https://orcid.org/0000-0003-3691-0324]
comment: There are usually 27-30 caudal vertebrae present in rodents and only 3-5 fused caudal vertebrae in human.
synonym: "increased caudal vertebrae size" EXACT []
synonym: "large caudal vertebrae" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology

[Term]
id: MP:0013613
name: abnormal volumetric bone mineral density
def: "anomaly of the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
synonym: "abnormal bone volume fraction" EXACT [PMID:36062328]
synonym: "abnormal BV/TV" EXACT [PMID:36062328]
synonym: "abnormal vBMD" EXACT []
is_a: MP:0010119 ! abnormal bone mineral density

[Term]
id: MP:0013614
name: abnormal areal bone mineral density
def: "anomaly of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
synonym: "abnormal aBMD" EXACT []
synonym: "abnormal areal bone density" EXACT []
is_a: MP:0010119 ! abnormal bone mineral density

[Term]
id: MP:0013615
name: increased volumetric bone mineral density
def: "increase in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
synonym: "elevated bone volume fraction" EXACT []
synonym: "increased BV/TV" EXACT []
synonym: "increased vBMD" EXACT []
synonym: "increased volumetric bone density" EXACT []
is_a: MP:0000062 ! increased bone mineral density
is_a: MP:0013613 ! abnormal volumetric bone mineral density

[Term]
id: MP:0013616
name: decreased volumetric bone mineral density
def: "reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
synonym: "decreased vBMD" EXACT []
synonym: "decreased volumetric bone density" EXACT []
synonym: "reduced bone volume fraction" EXACT []
synonym: "reduced BV/TV" EXACT []
is_a: MP:0000063 ! decreased bone mineral density
is_a: MP:0013613 ! abnormal volumetric bone mineral density

[Term]
id: MP:0013617
name: increased areal bone mineral density
def: "increase in the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
synonym: "increased aBMD" EXACT []
synonym: "increased areal bone density" EXACT []
is_a: MP:0000062 ! increased bone mineral density
is_a: MP:0013614 ! abnormal areal bone mineral density

[Term]
id: MP:0013618
name: decreased areal bone mineral density
def: "reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
synonym: "decreased aBMD" EXACT []
synonym: "decreased areal bone density" EXACT []
is_a: MP:0000063 ! decreased bone mineral density
is_a: MP:0013614 ! abnormal areal bone mineral density

[Term]
id: MP:0013619
name: abnormal long bone internal diameter
def: "anomaly of the cross-sectional distance that extends from one lateral edge of a long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the bone" [PMID:23197339]
synonym: "abnormal long bone endosteal diameter" EXACT []
synonym: "abnormal long bone inner diameter" EXACT []
synonym: "abnormal long bone marrow cavity diameter" EXACT []
synonym: "abnormal long bone medullary cavity diameter" EXACT []
is_a: MP:0003723 ! abnormal long bone morphology
is_a: MP:0014609 ! abnormal bone marrow cavity size

[Term]
id: MP:0013620
name: increased internal diameter of femur
def: "increased cross-sectional distance that extends from one lateral edge of the femur long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the femur" [PMID:23197339]
synonym: "increased endosteal diameter of femur" EXACT []
synonym: "increased femur bone marrow cavity diameter" EXACT []
synonym: "increased femur medullary cavity diameter" EXACT []
synonym: "increased inner diameter of femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0013619 ! abnormal long bone internal diameter

[Term]
id: MP:0013621
name: decreased internal diameter of femur
def: "reduced cross-sectional distance that extends from one lateral edge of the femur long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the femur" [PMID:23197339]
synonym: "decreased endosteal diameter of femur" EXACT []
synonym: "decreased femur bone marrow cavity diameter" EXACT []
synonym: "decreased femur medullary cavity diameter" EXACT []
synonym: "decreased inner diameter of femur" EXACT []
synonym: "reduced endosteal diameter of femur" EXACT []
synonym: "reduced inner diameter of femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0013619 ! abnormal long bone internal diameter

[Term]
id: MP:0013622
name: abnormal femur compact bone thickness
def: "reduced or increased width of the superficial layer of compact bone at the midpoint of the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal femur cortical bone morphology thickness" EXACT []
synonym: "abnormal femur dense bone thickness" EXACT []
synonym: "abnormal femur lamellar bone thickness" EXACT []
is_a: MP:0000134 ! abnormal compact bone thickness
is_a: MP:0000559 ! abnormal femur morphology

[Term]
id: MP:0013623
name: increased femur compact bone thickness
def: "increased width of the superficial layer of compact bone at the midpoint of the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased femur cortical bone morphology thickness" EXACT []
synonym: "increased femur dense bone thickness" EXACT []
synonym: "increased femur lamellar bone thickness" EXACT []
is_a: MP:0004148 ! increased compact bone thickness
is_a: MP:0013622 ! abnormal femur compact bone thickness

[Term]
id: MP:0013624
name: decreased femur compact bone thickness
def: "reduced width of the superficial layer of compact bone at the midpoint of the femur" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased femur cortical bone morphology thickness" EXACT []
synonym: "decreased femur dense bone thickness" EXACT []
synonym: "decreased femur lamellar bone thickness" EXACT []
synonym: "reduced femur cortical bone morphology thickness" EXACT []
synonym: "reduced femur dense bone thickness" EXACT []
synonym: "reduced femur lamellar bone thickness" EXACT []
is_a: MP:0000135 ! decreased compact bone thickness
is_a: MP:0013622 ! abnormal femur compact bone thickness

[Term]
id: MP:0013625
name: increased femur yield load
def: "increase in load (N) on the femur at which elastic deformation ends" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004149 ! increased bone strength

[Term]
id: MP:0013626
name: decreased femur yield load
def: "decrease in load (N) on the femur at which elastic deformation ends" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004991 ! decreased bone strength

[Term]
id: MP:0013627
name: increased vertebra yield load
def: "increase in load (N) on a vertebra at which elastic deformation ends" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004149 ! increased bone strength

[Term]
id: MP:0013628
name: decreased vertebra yield load
def: "decrease in load (N) on a vertebra at which elastic deformation ends" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004991 ! decreased bone strength

[Term]
id: MP:0013629
name: abnormal bone trabecular spacing
def: "any deviation in the amount of space between trabeculae in cancellous bone" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0000130 ! abnormal trabecular bone morphology

[Term]
id: MP:0013630
name: increased bone trabecular spacing
def: "increase in the amount of space between trabeculae in cancellous bone" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013629 ! abnormal bone trabecular spacing

[Term]
id: MP:0013631
name: decreased bone trabecular spacing
def: "decrease in the amount of space between trabeculae in cancellous bone" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013629 ! abnormal bone trabecular spacing

[Term]
id: MP:0013632
name: increased femur maximal load
def: "increase in the maximal load (N) that can be sustained by the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004149 ! increased bone strength

[Term]
id: MP:0013633
name: decreased femur maximal load
def: "decrease in the maximal load (N) that can be sustained by the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004991 ! decreased bone strength

[Term]
id: MP:0013634
name: increased femur fracture load
def: "increase in the load at which material failure occurs after plastic deformation" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004149 ! increased bone strength

[Term]
id: MP:0013635
name: decreased femur fracture load
def: "decrease in the load at which material failure occurs after plastic deformation" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004991 ! decreased bone strength

[Term]
id: MP:0013636
name: abnormal bone stiffness
def: "deviation in material stiffness (N/mm) during elastic deformation" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0001533 ! abnormal skeleton physiology

[Term]
id: MP:0013637
name: increased femur stiffness
def: "increase in material stiffness (N/mm) during elastic deformation in the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013640 ! increased bone stiffness

[Term]
id: MP:0013638
name: decreased femur stiffness
def: "decrease in material stiffness (N/mm) during elastic deformation in the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013639 ! decreased bone stiffness

[Term]
id: MP:0013639
name: decreased bone stiffness
def: "decrease in material stiffness (N/mm) during elastic deformation" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013636 ! abnormal bone stiffness

[Term]
id: MP:0013640
name: increased bone stiffness
def: "increase in material stiffness (N/mm) during elastic deformation" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013636 ! abnormal bone stiffness

[Term]
id: MP:0013641
name: increased vertebra stiffness
def: "increase in material stiffness (N/mm) during elastic deformation in a vertebra" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013640 ! increased bone stiffness

[Term]
id: MP:0013642
name: decreased vertebra stiffness
def: "decrease in material stiffness (N/mm) during elastic deformation in a vertebra" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0013639 ! decreased bone stiffness

[Term]
id: MP:0013643
name: decreased vertebra maximal load
def: "decrease in the maximal load (N) that can be sustained by a vertebra" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004991 ! decreased bone strength

[Term]
id: MP:0013644
name: increased vertebra maximal load
def: "increase in the maximal load (N) that can be sustained by a vertebra" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0004149 ! increased bone strength

[Term]
id: MP:0013645
name: increased energy dissipated prior to femur fracture
def: "increase in the fraction of total energy dissapated prior to ultimate material failure (low energy fracture) by the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0001542 ! abnormal bone strength

[Term]
id: MP:0013646
name: decreased energy dissipated prior to femur fracture
def: "decrease in the fraction of total energy dissapated prior to ultimate material failure (high energy fracture) by the femur" [https://orcid.org/0000-0001-7698-1552]
is_a: MP:0001542 ! abnormal bone strength

[Term]
id: MP:0013647
name: abnormal CD11b-high dendritic cell number
def: "anomaly in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008125 ! abnormal dendritic cell number

[Term]
id: MP:0013648
name: increased CD11b-high dendritic cell number
def: "increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008126 ! increased dendritic cell number
is_a: MP:0013647 ! abnormal CD11b-high dendritic cell number

[Term]
id: MP:0013649
name: decreased CD11b-high dendritic cell number
def: "reduction in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008127 ! decreased dendritic cell number
is_a: MP:0013647 ! abnormal CD11b-high dendritic cell number

[Term]
id: MP:0013650
name: abnormal CD11b-low dendritic cell number
def: "anomaly in the number of dendritic cells expressing low levels of CD11b which usually express CD8, depend on Irf8 and Batf3 for their development and are responsible for cross-presentation" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008125 ! abnormal dendritic cell number

[Term]
id: MP:0013651
name: increased CD11b-low dendritic cell number
def: "increase in the number of dendritic cells expressing low levels of CD11b which usually express CD8, depend on Irf8 and Batf3 for their development and are responsible for cross-presentation" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008126 ! increased dendritic cell number
is_a: MP:0013650 ! abnormal CD11b-low dendritic cell number

[Term]
id: MP:0013652
name: decreased CD11b-low dendritic cell number
def: "reduction in the number of dendritic cells expressing low levels of CD11b which usually express CD8, depend on Irf8 and Batf3 for their development and are responsible for cross-presentation" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008127 ! decreased dendritic cell number
is_a: MP:0013650 ! abnormal CD11b-low dendritic cell number

[Term]
id: MP:0013653
name: abnormal CD103-positive CD11b-low dendritic cell number
def: "anomaly in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008125 ! abnormal dendritic cell number

[Term]
id: MP:0013654
name: increased CD103-positive CD11b-low dendritic cell number
def: "increase in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008126 ! increased dendritic cell number
is_a: MP:0013653 ! abnormal CD103-positive CD11b-low dendritic cell number

[Term]
id: MP:0013655
name: decreased CD103-positive CD11b-low dendritic cell number
def: "reduction in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [https://orcid.org/0000-0002-6181-4695, PMID:23516985]
is_a: MP:0008127 ! decreased dendritic cell number
is_a: MP:0013653 ! abnormal CD103-positive CD11b-low dendritic cell number

[Term]
id: MP:0013656
name: abnormal hematopoietic cell morphology
def: "any structural anomaly of any of the cells of the hematopoietic lineage" [CL:0000988]
synonym: "abnormal haematopoietic cell morphology" EXACT []
synonym: "abnormal haemopoietic cell morphology" EXACT []
synonym: "abnormal hemopoietic cell morphology" EXACT []
is_a: MP:0002396 ! abnormal hematopoietic system morphology/development

[Term]
id: MP:0013657
name: abnormal blood cell morphology
def: "any structural anomaly of cells found in the blood" [CL:0000081]
is_a: MP:0013656 ! abnormal hematopoietic cell morphology

[Term]
id: MP:0013658
name: abnormal myeloid cell morphology
def: "any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage" [CL:0000763]
is_a: MP:0013656 ! abnormal hematopoietic cell morphology

[Term]
id: MP:0013659
name: abnormal erythroid lineage cell morphology
def: "any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes" [CL:0000764]
is_a: MP:0013658 ! abnormal myeloid cell morphology

[Term]
id: MP:0013660
name: abnormal bone marrow hematopoietic cell morphology
def: "any structural anomaly of hematopoietic cells that are resident in the bone marrow, including hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes" [CL:1001610]
synonym: "abnormal bone marrow haematopoietic cell morphology" EXACT []
is_a: MP:0002398 ! abnormal bone marrow cell morphology/development
is_a: MP:0013656 ! abnormal hematopoietic cell morphology

[Term]
id: MP:0013661
name: abnormal myeloid cell number
def: "any anomaly in the expected number of cells of the myeloid lineage" [CL:0000763]
is_a: MP:0011180 ! abnormal hematopoietic cell number
is_a: MP:0013658 ! abnormal myeloid cell morphology

[Term]
id: MP:0013662
name: decreased myeloid cell number
def: "reduction in the expected number of cells of the myeloid lineage" [CL:0000763]
is_a: MP:0011182 ! decreased hematopoietic cell number
is_a: MP:0013661 ! abnormal myeloid cell number

[Term]
id: MP:0013663
name: increased myeloid cell number
def: "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
is_a: MP:0011181 ! increased hematopoietic cell number
is_a: MP:0013661 ! abnormal myeloid cell number

[Term]
id: MP:0013664
name: abnormal immature B cell number
def: "anomaly in the number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7]
synonym: "abnormal number of immature B cells" EXACT []
synonym: "abnormal number of immature B lymphocytes" EXACT []
synonym: "abnormal number of immature B-cells" EXACT []
synonym: "abnormal number of immature B-lymphocytes" EXACT []
is_a: MP:0002458 ! abnormal B cell number
is_a: MP:0005022 ! abnormal immature B cell morphology

[Term]
id: MP:0013665
name: abnormal immature NK cell number
def: "anomaly in the number of NK cells lacking expression of the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal immature natural killer cell number" EXACT []
is_a: MP:0008043 ! abnormal NK cell number
is_a: MP:0013699 ! abnormal immature NK cell morphology

[Term]
id: MP:0013666
name: decreased immature NK cell number
def: "reduction in the number of NK cells lacking expression of the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased immature natural killer cell number" EXACT []
synonym: "reduced immature natural killer cell number" EXACT []
is_a: MP:0008045 ! decreased NK cell number
is_a: MP:0013665 ! abnormal immature NK cell number

[Term]
id: MP:0013667
name: increased immature NK cell number
def: "increase in the number of NK cells lacking expression of the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased immature natural killer cell number" EXACT []
is_a: MP:0008044 ! increased NK cell number
is_a: MP:0013665 ! abnormal immature NK cell number

[Term]
id: MP:0013668
name: abnormal Ly6C-positive immature NK cell number
def: "anomaly in the number of immature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal Ly6C-positive immature natural killer cell number" EXACT []
is_a: MP:0013665 ! abnormal immature NK cell number

[Term]
id: MP:0013669
name: decreased Ly6C-positive immature NK cell number
def: "reduction in the number of immature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased Ly6C-positive immature natural killer cell number" EXACT []
synonym: "reduced Ly6C-positive immature NK cell number" EXACT []
is_a: MP:0013666 ! decreased immature NK cell number
is_a: MP:0013668 ! abnormal Ly6C-positive immature NK cell number

[Term]
id: MP:0013670
name: increased Ly6C-positive immature NK cell number
def: "increase in the number of immature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased Ly6C-positive immature natural killer cell number" EXACT []
is_a: MP:0013667 ! increased immature NK cell number
is_a: MP:0013668 ! abnormal Ly6C-positive immature NK cell number

[Term]
id: MP:0013671
name: abnormal mature NK cell number
def: "anomaly in the number of NK cells expressing the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008043 ! abnormal NK cell number
is_a: MP:0013700 ! abnormal mature NK cell morphology

[Term]
id: MP:0013672
name: decreased mature NK cell number
def: "reduction in the number of NK cells expressing the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased mature natural killer cell number" EXACT []
synonym: "reduced mature NK cell number" EXACT []
is_a: MP:0008045 ! decreased NK cell number
is_a: MP:0013671 ! abnormal mature NK cell number

[Term]
id: MP:0013673
name: increased mature NK cell number
def: "increase in the number of NK cells expressing the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased mature natural killer cell number" EXACT []
is_a: MP:0008044 ! increased NK cell number
is_a: MP:0013671 ! abnormal mature NK cell number

[Term]
id: MP:0013674
name: abnormal Ly6C-positive mature NK cell number
def: "anomaly in the number of mature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal Ly6C-positive mature natural killer cell number" EXACT []
is_a: MP:0013671 ! abnormal mature NK cell number

[Term]
id: MP:0013675
name: decreased Ly6C-positive mature NK cell number
def: "reduction in the number of mature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased Ly6C-positive mature natural killer cell number" EXACT []
synonym: "reduced Ly6C-positive mature NK cell number" EXACT []
is_a: MP:0013672 ! decreased mature NK cell number
is_a: MP:0013674 ! abnormal Ly6C-positive mature NK cell number

[Term]
id: MP:0013676
name: increased Ly6C-positive mature NK cell number
def: "increase in the number of mature NK cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013673 ! increased mature NK cell number
is_a: MP:0013674 ! abnormal Ly6C-positive mature NK cell number

[Term]
id: MP:0013677
name: abnormal Ly6C-positive NK T cell number
def: "anomaly in the number of NK T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal Ly6C-positive natural killer T cell number" EXACT []
is_a: MP:0008038 ! abnormal NK T cell number

[Term]
id: MP:0013678
name: decreased Ly6C-positive NK T cell number
def: "reduction in the number of NK T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased Ly6C-positive natural killer T cell number" EXACT []
synonym: "reduced Ly6C-positive NK T cell number" EXACT []
is_a: MP:0008040 ! decreased NK T cell number
is_a: MP:0013677 ! abnormal Ly6C-positive NK T cell number

[Term]
id: MP:0013679
name: increased Ly6C-positive NK T cell number
def: "increase in the number of NK T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased Ly6C-positive natural killer T cell number" EXACT []
is_a: MP:0008039 ! increased NK T cell number
is_a: MP:0013677 ! abnormal Ly6C-positive NK T cell number

[Term]
id: MP:0013680
name: abnormal germinal center B cell number
def: "anomaly in the number of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314]
synonym: "abnormal germinal centre B cell number" EXACT []
is_a: MP:0002458 ! abnormal B cell number
is_a: MP:0008176 ! abnormal germinal center B cell morphology

[Term]
id: MP:0013681
name: abnormal early germinal center B cell number
def: "any structural anomaly of germinal center B cells with residual expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal early germinal centre B cell number" EXACT []
is_a: MP:0013680 ! abnormal germinal center B cell number

[Term]
id: MP:0013682
name: abnormal late germinal center B cell number
def: "anomaly in the number of germinal center B cells expressing IgG1 and lacking expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal late germinal centre B cell number" EXACT []
is_a: MP:0013680 ! abnormal germinal center B cell number

[Term]
id: MP:0013683
name: decreased early germinal center B cell number
def: "reduction in the number of germinal center B cells with residual expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased early germinal centre B cell number" EXACT []
synonym: "reduced early germinal center B cell number" EXACT []
synonym: "reduced early germinal centre B cell number" EXACT []
is_a: MP:0008178 ! decreased germinal center B cell number
is_a: MP:0013681 ! abnormal early germinal center B cell number

[Term]
id: MP:0013684
name: increased early germinal center B cell number
def: "increase in the number of germinal center B cells with residual expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased early germinal centre B cell number" EXACT []
is_a: MP:0008177 ! increased germinal center B cell number
is_a: MP:0013681 ! abnormal early germinal center B cell number

[Term]
id: MP:0013685
name: decreased late germinal center B cell number
def: "reduction in the number of germinal center B cells expressing IgG1 and lacking expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "decreased late germinal centre B cell number" EXACT []
synonym: "reduced late germinal center B cell number" EXACT []
synonym: "reduced late germinal centre B cell number" EXACT []
is_a: MP:0008178 ! decreased germinal center B cell number
is_a: MP:0013682 ! abnormal late germinal center B cell number

[Term]
id: MP:0013686
name: increased late germinal center B cell number
def: "increase in the number of germinal center B cells expressing IgG1 and lacking expression of IgD" [https://orcid.org/0000-0002-6181-4695]
synonym: "increased late germinal centre B cell number" EXACT []
is_a: MP:0008177 ! increased germinal center B cell number
is_a: MP:0013682 ! abnormal late germinal center B cell number

[Term]
id: MP:0013687
name: abnormal CD5-positive T cell number
def: "anomaly in the number of T cells expressing CD5, a negative regulator of T cell signaling" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0006387 ! abnormal T cell number

[Term]
id: MP:0013688
name: decreased CD5-positive T cell number
def: "reduction in the number of T cells expressing CD5, a negative regulator of T cell signaling" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced CD5-positive T cell number" EXACT []
is_a: MP:0013687 ! abnormal CD5-positive T cell number

[Term]
id: MP:0013689
name: increased CD5-positive T cell number
def: "increase in the number of T cells expressing CD5, a negative regulator of T cell signaling" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013687 ! abnormal CD5-positive T cell number

[Term]
id: MP:0013690
name: abnormal CD5-positive Ly6C-positive T cell number
def: "anomaly in the number of CD5-positive T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013687 ! abnormal CD5-positive T cell number

[Term]
id: MP:0013691
name: decreased CD5-positive Ly6C-positive T cell number
def: "reduction in the number of CD5-positive T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced CD5-positive Ly6C-positive T cell number" EXACT []
is_a: MP:0013688 ! decreased CD5-positive T cell number
is_a: MP:0013690 ! abnormal CD5-positive Ly6C-positive T cell number

[Term]
id: MP:0013692
name: increased CD5-positive Ly6C-positive T cell number
def: "increase in the number of CD5-positive T cells expressing the memory marker Ly6C" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013689 ! increased CD5-positive T cell number
is_a: MP:0013690 ! abnormal CD5-positive Ly6C-positive T cell number

[Term]
id: MP:0013693
name: abnormal hemopoiesis
def: "any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]
synonym: "abnormal blood cell biosynthesis" EXACT []
synonym: "abnormal blood cell formation" EXACT []
synonym: "abnormal haematopoiesis" EXACT []
synonym: "abnormal haemopoiesis" EXACT []
synonym: "abnormal hematopoiesis" EXACT []
synonym: "hematopoiesis abnormalities" EXACT []
is_a: MP:0002429 ! abnormal blood cell morphology/development
is_a: MP:0013657 ! abnormal blood cell morphology

[Term]
id: MP:0013694
name: abnormal granulocyte monocyte progenitor cell morphology
def: "any structural anomaly of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
synonym: "abnormal CFU-GM morphology" EXACT []
synonym: "abnormal colony forming unit granulocyte macrophage morphology" EXACT []
synonym: "abnormal GMP morphology" EXACT []
synonym: "abnormal granulocyte-macrophage progenitor morphology" EXACT []
synonym: "abnormal granulocyte/monocyte precursor morphology" EXACT []
synonym: "abnormal granulocyte/monocyte progenitor morphology" EXACT []
is_a: MP:0013658 ! abnormal myeloid cell morphology
is_a: MP:0013660 ! abnormal bone marrow hematopoietic cell morphology
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0013695
name: abnormal granulocyte monocyte progenitor cell number
def: "anomaly in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
synonym: "abnormal CFU-GM cell number" EXACT []
synonym: "abnormal colony forming unit granulocyte macrophage cell number" EXACT []
synonym: "abnormal GMP cell number" EXACT []
synonym: "abnormal granulocyte-macrophage progenitor cell number" EXACT []
synonym: "abnormal granulocyte/monocyte precursor cell number" EXACT []
synonym: "abnormal granulocyte/monocyte progenitor cell number" EXACT []
is_a: MP:0013694 ! abnormal granulocyte monocyte progenitor cell morphology

[Term]
id: MP:0013696
name: increased granulocyte monocyte progenitor cell number
def: "increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
synonym: "increased CFU-GM cell number" EXACT []
synonym: "increased colony forming unit granulocyte macrophage cell number" EXACT []
synonym: "increased GMP cell number" EXACT []
synonym: "increased granulocyte-macrophage progenitor cell number" EXACT []
synonym: "increased granulocyte/monocyte precursor cell number" EXACT []
synonym: "increased granulocyte/monocyte progenitor cell number" EXACT []
is_a: MP:0013695 ! abnormal granulocyte monocyte progenitor cell number

[Term]
id: MP:0013697
name: decreased granulocyte monocyte progenitor cell number
def: "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
synonym: "decreased CFU-GM cell number" EXACT []
synonym: "decreased colony forming unit granulocyte macrophage cell number" EXACT []
synonym: "decreased GMP cell number" EXACT []
synonym: "decreased granulocyte-macrophage progenitor cell number" EXACT []
synonym: "decreased granulocyte/monocyte precursor cell number" EXACT []
synonym: "decreased granulocyte/monocyte progenitor cell number" EXACT []
synonym: "reduced CFU-GM cell number" EXACT []
synonym: "reduced colony forming unit granulocyte macrophage cell number" EXACT []
synonym: "reduced GMP cell number" EXACT []
synonym: "reduced granulocyte monocyte progenitor cell number" EXACT []
synonym: "reduced granulocyte-macrophage progenitor cell number" EXACT []
synonym: "reduced granulocyte/monocyte precursor cell number" EXACT []
synonym: "reduced granulocyte/monocyte progenitor cell number" EXACT []
is_a: MP:0013695 ! abnormal granulocyte monocyte progenitor cell number

[Term]
id: MP:0013698
name: absent granulocyte monocyte progenitor cells
def: "absence of hematopoietic progenitor cells that are committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
synonym: "absent CFU-GM cells" EXACT []
synonym: "absent colony forming unit granulocyte macrophage cells" EXACT []
synonym: "absent GMP cells" EXACT []
synonym: "absent granulocyte-macrophage progenitor cells" EXACT []
synonym: "absent granulocyte/monocyte precursor cells" EXACT []
synonym: "absent granulocyte/monocyte progenitor cells" EXACT []
is_a: MP:0013697 ! decreased granulocyte monocyte progenitor cell number

[Term]
id: MP:0013699
name: abnormal immature NK cell morphology
def: "any structural anomaly in the number of NK cells lacking expression of the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal immature natural killer cell morphology" EXACT []
is_a: MP:0005068 ! abnormal NK cell morphology

[Term]
id: MP:0013700
name: abnormal mature NK cell morphology
def: "any structural anomaly of NK cells expressing the maturation marker CD11b" [https://orcid.org/0000-0002-6181-4695]
synonym: "abnormal lymphokine activated killer cell morphology" EXACT []
synonym: "abnormal mature natural killer cell morphology" EXACT []
is_a: MP:0005068 ! abnormal NK cell morphology

[Term]
id: MP:0013701
name: abnormal mature B cell number
def: "anomaly in the number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785]
is_a: MP:0002458 ! abnormal B cell number

[Term]
id: MP:0013702
name: abnormal megakaryocyte-erythroid progenitor cell morphology
def: "any structural anomaly of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
synonym: "abnormal CFU-EM morphology" EXACT []
synonym: "abnormal CFU-MegE morphology" EXACT []
synonym: "abnormal colony forming unit erythroid megakaryocyte morphology" EXACT []
synonym: "abnormal Meg/E progenitor morphology" EXACT []
synonym: "abnormal megakaryocyte/erythrocyte progenitor morphology" EXACT []
synonym: "abnormal megakaryocyte/erythroid progenitor cell morphology" EXACT []
synonym: "abnormal MEP morphology" EXACT []
is_a: MP:0013658 ! abnormal myeloid cell morphology
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0013703
name: abnormal megakaryocyte-erythroid progenitor cell number
def: "anomaly in the number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
synonym: "abnormal CFU-EM number" EXACT []
synonym: "abnormal CFU-MegE number" EXACT []
synonym: "abnormal colony forming unit erythroid megakaryocyte number" EXACT []
synonym: "abnormal Meg/E progenitor number" EXACT []
synonym: "abnormal megakaryocyte/erythrocyte progenitor number" EXACT []
synonym: "abnormal megakaryocyte/erythroid progenitor cell number" EXACT []
synonym: "abnormal MEP number" EXACT []
is_a: MP:0013702 ! abnormal megakaryocyte-erythroid progenitor cell morphology

[Term]
id: MP:0013704
name: increased megakaryocyte-erythroid progenitor cell number
def: "increase in the number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
synonym: "increased CFU-EM number" EXACT []
synonym: "increased CFU-MegE number" EXACT []
synonym: "increased colony forming unit erythroid megakaryocyte number" EXACT []
synonym: "increased Meg/E progenitor number" EXACT []
synonym: "increased megakaryocyte/erythrocyte progenitor number" EXACT []
synonym: "increased megakaryocyte/erythroid progenitor cell number" EXACT []
synonym: "increased MEP number" EXACT []
is_a: MP:0013703 ! abnormal megakaryocyte-erythroid progenitor cell number

[Term]
id: MP:0013705
name: decreased megakaryocyte-erythroid progenitor cell number
def: "reduced number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
synonym: "decreased CFU-EM number" EXACT []
synonym: "decreased CFU-MegE number" EXACT []
synonym: "decreased colony forming unit erythroid megakaryocyte number" EXACT []
synonym: "decreased Meg/E progenitor number" EXACT []
synonym: "decreased megakaryocyte/erythrocyte progenitor number" EXACT []
synonym: "decreased megakaryocyte/erythroid progenitor cell number" EXACT []
synonym: "decreased MEP number" EXACT []
synonym: "reduced CFU-EM number" EXACT []
synonym: "reduced CFU-MegE number" EXACT []
synonym: "reduced colony forming unit erythroid megakaryocyte number" EXACT []
synonym: "reduced Meg/E progenitor number" EXACT []
synonym: "reduced megakaryocyte-erythroid progenitor cell number" EXACT []
synonym: "reduced megakaryocyte/erythrocyte progenitor number" EXACT []
synonym: "reduced megakaryocyte/erythroid progenitor cell number" EXACT []
synonym: "reduced MEP number" EXACT []
is_a: MP:0013703 ! abnormal megakaryocyte-erythroid progenitor cell number

[Term]
id: MP:0013706
name: absent megakaryocyte-erythroid progenitor cells
def: "absence of progenitor cells committed to the megakaryocyte and erythroid lineages" [CL:0000050]
synonym: "absent CFU-EM cells" EXACT []
synonym: "absent CFU-MegE cells" EXACT []
synonym: "absent colony forming unit erythroid megakaryocyte cells" EXACT []
synonym: "absent Meg/E progenitor cells" EXACT []
synonym: "absent megakaryocyte/erythrocyte progenitor cells" EXACT []
synonym: "absent megakaryocyte/erythroid progenitor cell cells" EXACT []
synonym: "absent MEP cells" EXACT []
is_a: MP:0013705 ! decreased megakaryocyte-erythroid progenitor cell number

[Term]
id: MP:0013707
name: abnormal hematopoietic precursor cell morphology
def: "any structural anomaly of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [CL:0008001]
synonym: "abnormal haematopoietic precursor cell morphology" EXACT []
synonym: "abnormal HPC morphology" EXACT []
synonym: "abnormal HPCs morphology" EXACT []
is_a: MP:0013656 ! abnormal hematopoietic cell morphology

[Term]
id: MP:0013708
name: abnormal hematopoietic precursor cell number
def: "anomaly in the number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [CL:0008001]
synonym: "abnormal haematopoietic precursor cell number" EXACT []
synonym: "abnormal HPC number" EXACT []
synonym: "abnormal HPCs number" EXACT []
is_a: MP:0013707 ! abnormal hematopoietic precursor cell morphology

[Term]
id: MP:0013709
name: abnormal cervical mammary gland morphology
def: "any structural anomaly of either of two mammary glands located in the cervical (i.e. neck) region, forward of the axial area of the forelimbs (mice have a single pair of cervical mammary glands)" [ISBN:1483269485, PMID:22949413]
comment: The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013710
name: abnormal abdominal mammary gland morphology
def: "any structural anomaly of either of the two mammary glands located in the abdominal wall (mice have a single pair of abdominal mammary glands)" [ISBN:1483269485, PMID:22949413]
comment: The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013711
name: abnormal inguinal mammary gland morphology
def: "any structural anomaly of either of the two mammary glands located in the inguinal region between the hind legs (mice have a single pair of inguinal mammary glands)" [ISBN:1483269485, PMID:22949413]
comment: The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013712
name: abnormal thoracic mammary gland morphology
def: "any structural anomaly of any of the mammary glands located in the thoracic (i.e. pectoral or chest wall) region (mice have two pairs of thoracic mammary glands)" [ISBN:1483269485, PMID:22949413]
comment: The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013713
name: decreased nipple size
def: "reduced size of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased papilla mammae size" EXACT []
synonym: "decreased teat size" EXACT []
synonym: "decreased thele mammae size" EXACT []
synonym: "decreased thelium mammae size" EXACT []
synonym: "reduced papilla mammae size" EXACT []
synonym: "reduced teat size" EXACT []
synonym: "reduced thele mammae size" EXACT []
synonym: "reduced thelium mammae size" EXACT []
synonym: "small nipple" EXACT []
synonym: "small papilla mammae" EXACT []
synonym: "small teat" EXACT []
synonym: "small thele" EXACT []
synonym: "small thele mammae" EXACT []
synonym: "small thelium" EXACT []
synonym: "small thelium mammae" EXACT []
is_a: MP:0006078 ! abnormal nipple morphology

[Term]
id: MP:0013714
name: abnormal mammary gland number
def: "anomaly in the expected number of the specialized accessory gland of the skin of mammals that secretes milk" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal breast number" EXACT []
synonym: "abnormal Brustdruese number" EXACT []
synonym: "abnormal glandula mammaria number" EXACT []
synonym: "abnormal Lactiferous gland number" EXACT []
synonym: "abnormal lactiferous gland number" EXACT []
synonym: "abnormal Lobe of breast number" EXACT []
synonym: "abnormal lobe of breast number" EXACT []
synonym: "abnormal Lobe of mammary gland number" EXACT []
synonym: "abnormal lobe of mammary gland number" EXACT []
synonym: "abnormal mamma number" EXACT []
synonym: "abnormal mammae number" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013715
name: decreased mammary gland number
def: "fewer than the expected number of the specialized accessory gland of the skin of mammals that secretes milk" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased breast number" EXACT []
synonym: "decreased Brustdruese number" EXACT []
synonym: "decreased glandula mammaria number" EXACT []
synonym: "decreased Lactiferous gland number" EXACT []
synonym: "decreased lactiferous gland number" EXACT []
synonym: "decreased Lobe of breast number" EXACT []
synonym: "decreased lobe of breast number" EXACT []
synonym: "decreased Lobe of mammary gland number" EXACT []
synonym: "decreased lobe of mammary gland number" EXACT []
synonym: "decreased mamma number" EXACT []
synonym: "decreased mammae number" EXACT []
is_a: MP:0013714 ! abnormal mammary gland number

[Term]
id: MP:0013716
name: hypolactation
def: "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lactation" EXACT []
synonym: "decreased milk production" EXACT []
synonym: "decreased milk secretion" EXACT []
synonym: "hypogalactia" EXACT []
synonym: "insufficient lactation" EXACT []
synonym: "low milk supply" EXACT []
synonym: "reduced lactation" EXACT []
synonym: "reduced milk production" EXACT []
synonym: "reduced milk secretion" EXACT []
is_a: MP:0001882 ! abnormal lactation

[Term]
id: MP:0013717
name: hyperlactation
def: "secretion of milk from the mammary gland in excessive amount, or for an abnormally prolonged period" [https://orcid.org/0000-0002-6490-7723]
synonym: "excessive lactation" EXACT []
synonym: "hypergalactia" EXACT []
synonym: "increased lactation" EXACT []
synonym: "increased milk production" EXACT []
synonym: "increased milk secretion" EXACT []
synonym: "superlactation" EXACT []
is_a: MP:0001882 ! abnormal lactation

[Term]
id: MP:0013718
name: galactostasis
def: "abnormal accumulation of milk within the mammary gland alveoli and ducts due to failure of ejection (letdown) from the gland; may be associated with nipple anatomic abnormalities" [https://orcid.org/0000-0002-6490-7723]
synonym: "failure of milk ejection" EXACT []
synonym: "milk ejection failure" EXACT []
synonym: "milk stasis" EXACT []
is_a: MP:0003838 ! abnormal milk ejection

[Term]
id: MP:0013719
name: pale mammary gland
def: "loss of the normal reddish-pink color of mammary gland tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0013720
name: abnormal mammary line morphology
def: "any structural anomaly of either of the presumptive bilateral epidermal ridges (milk lines) formed at the onset of mammogenesis and running in an anteroposterior direction ventrally between fore- and hindlimbs, one line along each flank of the embryo; in mouse, mammary gland development begins shortly after mid-gestation (about E10.5); epidermal cells within the milk line become columnar and multilayered, defining a ridge that protrudes above and below the plane of the single-layered primitive epidermis or periderm; by E11.5, five pairs of lens-shaped placodes form along the mammary line at the site of each future nipple" [PMID:12558599, PMID:16524451]
synonym: "abnormal mammary fold morphology" EXACT []
synonym: "abnormal mammary gland ridge morphology" EXACT []
synonym: "abnormal mammary ridge morphology" EXACT []
synonym: "abnormal milk line morphology" EXACT []
is_a: MP:0000628 ! abnormal mammary gland development

[Term]
id: MP:0013721
name: abnormal mammary placode morphology
def: "any structural anomaly of the transient lens-shaped thickening of surface ectoderm that will give rise to the mammary bud proper; in mouse, five pairs of symmetrically positioned mammary placodes (three thoracic and two inguinal) form at reproducible locations along the mammary line at E11.5; the individual pairs develop asynchronously and in a distinct order; pair 3 is first, followed by pair 4, then by pairs 1 and 5 (which develop together), and finally by pair 2; the orientation of placodal cells is not uniform, suggesting that placodes are formed by migration of cells from the mammary line; between E11.5 and E12.5, each mammary placode expands and invaginates into the underlying mesenchyme to form an early bulb-shaped mammary bud" [PMID:16168142, PMID:20484386]
is_a: MP:0004135 ! abnormal mammary gland embryonic development

[Term]
id: MP:0013722
name: abnormal circulating tyrosine level
def: "aberrant concentration in the blood of tyrosine or 4-hydroxyphenylalanine, a non-essential amino acid with a polar side group present in most proteins and synthesized metabolically from phenylalanine; tyrosine is a precursor of melanin, catecholamines, and thyroid hormones" [https://medical-dictionary.thefreedictionary.com/tyrosine]
is_a: MP:0005311 ! abnormal circulating amino acid level

[Term]
id: MP:0013723
name: increased circulating tyrosine level
def: "increase in the amount per unit of blood of tyrosine" [https://orcid.org/0000-0002-6490-7723]
synonym: "tyrosinaemia" EXACT []
synonym: "tyrosinemia" EXACT []
is_a: MP:0013722 ! abnormal circulating tyrosine level
is_a: MP:0014530 ! increased circulating amino acid level

[Term]
id: MP:0013724
name: decreased circulating tyrosine level
def: "reduction in the amount per unit of blood of tyrosine" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced circulating tyrosine level" EXACT []
is_a: MP:0013722 ! abnormal circulating tyrosine level
is_a: MP:0014531 ! decreased circulating amino acid level

[Term]
id: MP:0013725
name: abnormal mammary gland cord morphology
def: "any structural anomaly of the solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis; in female mouse embryos, the primary mammary cord (mammary sprout) is formed between E15.5 and E16.5; once the primary cord reaches the adipocytes of the fat pad (around E16), it begins to branch in a characteristic dichotomous fashion to form the initial ductal tree" [http://www.informatics.jax.org/greenbook/frames/frame13.shtml, PMID:15342465, PMID:18296651]
synonym: "abnormal mammary cord morphology" EXACT []
synonym: "abnormal mammary sprout morphology" EXACT []
is_a: MP:0009503 ! abnormal mammary gland duct morphology

[Term]
id: MP:0013726
name: abnormal mammary gland cord formation
def: "any anomaly in the process by which the mammary gland cord forms by elongation of the mammary bud; in female mouse embryos, the cord is formed between E15.5 and E16.5, once the elongating bud breaks through the primary mammary mesenchyme and reaches the fat pad precursor, and remains connected to the epidermis; by E16.5 a lumen develops within the sprout resulting in a primary duct opening to the exterior, and the nipple forms by differentiation of the overlying epidermis in response to signals from specialized mammary mesenchyme; in male mouse embryos, the activation of androgen receptors causes the mammary buds to separate from the epithelium between E14.5 and E15.5 and subsequently degenerate" [GO:0060616, http://www.informatics.jax.org/greenbook/frames/frame13.shtml, PMID:15342465, PMID:18296651]
synonym: "abnormal mammary cord formation" EXACT []
synonym: "abnormal mammary sprout formation" EXACT []
synonym: "abnormal mammary sprouting" EXACT []
is_a: MP:0000628 ! abnormal mammary gland development
is_a: MP:0013725 ! abnormal mammary gland cord morphology

[Term]
id: MP:0013727
name: abnormal nipple sheath morphology
def: "any structural abnormality of the circular ingrowth of the epidermis around the origin of the mammary cord (mammary sprout); in female mouse embryos, the nipple sheath is the first histological evidence of nipple formation seen at E16.5; at E18, the epidermis at the bottom of this epidermal ingrowth is lifted, making a rounded elevated portion, which is the anlage of the nipple" [GO:0060659, PMID:12558599]
is_a: MP:0006078 ! abnormal nipple morphology

[Term]
id: MP:0013728
name: abnormal nipple sheath formation
def: "any anomaly in the developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis; in female mouse embryos, this process begins with a circular ingrowth of the epidermis around the origin of the mammary cord (mammary sprout) at E16.5 and ends before the underlying epidermis begins to elevate" [GO:0060659, PMID:12558599]
is_a: MP:0013727 ! abnormal nipple sheath morphology

[Term]
id: MP:0013729
name: absent nipple sheath
def: "absence or failure of formation of the circular ingrowth of the epidermis around the origin of the mammary cord (mammary sprout); in female mouse embryos, the nipple sheath is the first histological evidence of nipple formation seen at E16.5" [PMID:12558599]
is_a: MP:0013727 ! abnormal nipple sheath morphology

[Term]
id: MP:0013730
name: glutathionuria
def: "elevated concentrations of the reducing agent glutathione in urine" [MGI:llw2]
synonym: "increased urine glutathione level" EXACT []
synonym: "increased urine GSH level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0012606 ! increased glutathione level

[Term]
id: MP:0013731
name: immature cataract
def: "an early stage cataract in which the lens is partially opaque, absorbs fluid and increases by swelling; the lens is only slightly opaque and the cortex is clear" [ISBN:978-0-323-05290-0, ISBN:978-0-7020-2788-8]
synonym: "cataracta immatura" EXACT []
synonym: "immature cataracts" EXACT []
is_a: MP:0001304 ! cataract

[Term]
id: MP:0013732
name: mature cataract
def: "cataract in which the both the lens nucleus and cortex are opaque and lens fibers are swollen" [ISBN:978-0-323-05290-0]
synonym: "mature cataracts" EXACT []
synonym: "ripe cataract" EXACT []
is_a: MP:0001304 ! cataract

[Term]
id: MP:0013733
name: squamous metaplasia of bulbourethral gland
def: "a benign non-cancerous transformation of the bulbourethral glandular epithelium into stratified squamous epithelium; keratinization may be present" [https://orcid.org/0000-0002-6490-7723, PMID:19117991]
synonym: "squamous metaplasia of bulbo-urethral gland" EXACT []
synonym: "squamous metaplasia of Cowper's gland" EXACT []
synonym: "squamous metaplasia of glandula bulbourethralis" EXACT []
synonym: "squamous metaplasia of Mery gland" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology

[Term]
id: MP:0013734
name: squamous metaplasia of preputial gland
def: "a benign non-cancerous transformation of the preputial glandular epithelium into stratified squamous epithelium; keratinization may be present" [https://orcid.org/0000-0002-6490-7723, PMID:19117991]
is_a: MP:0013329 ! abnormal preputial gland morphology

[Term]
id: MP:0013735
name: squamous metaplasia of urethral gland
def: "a benign non-cancerous transformation of the urethral glandular epithelium into stratified squamous epithelium; keratinization may be present" [https://orcid.org/0000-0002-6490-7723, PMID:19117991]
is_a: MP:0011792 ! abnormal urethral gland morphology

[Term]
id: MP:0013736
name: abnormal bulbourethral gland development
def: "aberrant formation or incomplete differentiation of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; in mouse, bulbourethral glands are first identifiable at E17.5 and epithelial branching normally starts at postnatal day P1; during development, bulbourethral glands arise as epithelial outgrowths of the endodermal urogenital sinus invading the condensed mesenchyme flanking the primitive urethra; during subsequent development the epithelium branches extensively, filling the mesenchymal capsule and giving rise to the highly arborized ductal system of the mature organ" [https://orcid.org/0000-0002-6490-7723, PMID:12220125]
synonym: "abnormal bulbo-urethral gland development" EXACT []
synonym: "abnormal Cowper's gland development" EXACT []
synonym: "abnormal glandula bulbourethralis development" EXACT []
synonym: "abnormal Mery gland development" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology

[Term]
id: MP:0013737
name: small bulbourethral gland
def: "reduced size of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle" [https://orcid.org/0000-0002-6490-7723, PMID:19117991]
synonym: "decreased bulbourethral gland size" EXACT []
synonym: "reduced bulbourethral gland size" EXACT []
synonym: "small bulbo-urethral gland" EXACT []
synonym: "small Cowper's gland" EXACT []
synonym: "small glandula bulbourethralis" EXACT []
synonym: "small Mery gland" EXACT []
is_a: MP:0001169 ! abnormal bulbourethral gland morphology

[Term]
id: MP:0013738
name: abnormal testis tunica albuginea morphology
def: "any structural anomaly of the dense fibrous connective tissue layer that covers the testis" [https://orcid.org/0000-0002-6490-7723, PMID:16412416]
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0013739
name: abnormal testis tunica vaginalis morphology
def: "any structural anomaly of the outer coelomic epithelial covering of the testis; a sac of serous tissue covering the testis and the epididymis within which the testis can move about; it covers the tunica albuginea" [https://orcid.org/0000-0002-6490-7723, PMID:17452023]
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0013740
name: Meibomian gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the Meibomian gland, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723, PMID:23792463]
synonym: "hyperplastic Meibomian gland" EXACT []
synonym: "hyperplastic tarsal gland" EXACT []
synonym: "tarsal gland hyperplasia" EXACT []
is_a: MP:0013386 ! enlarged Meibomian gland

[Term]
id: MP:0013741
name: absent thymus corticomedullary boundary
def: "complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [https://orcid.org/0000-0002-6490-7723, PMID:17067941]
synonym: "absent thymic corticomedullary boundary" EXACT []
synonym: "absent thymus CMZ" EXACT []
synonym: "absent thymus cortico-medullary boundary" EXACT []
synonym: "absent thymus cortico-medullary junction" EXACT []
synonym: "absent thymus cortico-medullary zone" EXACT []
synonym: "absent thymus corticomedullary junction" EXACT []
synonym: "absent thymus corticomedullary zone" EXACT []
is_a: MP:0009543 ! abnormal thymus corticomedullary boundary morphology

[Term]
id: MP:0013742
name: absent ciliary body
def: "absence of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0013743
name: ciliary body hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the ciliary body, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "hypoplastic ciliary body" EXACT []
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0013744
name: abnormal conjunctival sac morphology
def: "any structural anomaly of the space bound by the conjunctival membrane between the palpebral and bulbar conjunctiva, into which the lacrimal fluid is secreted; it is a closed space when eye is closed; when eye is open, the sac is open anteriorly through the palpebral fissure (between the eyelids)" [http://www.medilexicon.com/medicaldictionary.php?t=79277, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal saccus conjunctivalis morphology" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0013745
name: abnormal eyelid margin morphology
def: "any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium" [http://one.aao.org/bcscsnippetdetail.aspx?id=2b7328d7-5eb2-4df3-812a-031ff1c1f904, http://www.medilexicon.com/medicaldictionary.php?s=palpebral+margins, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eyelid border morphology" EXACT []
synonym: "abnormal limbi palpebrales morphology" EXACT []
synonym: "abnormal margo palpebrae morphology" EXACT []
synonym: "abnormal palpebral margin morphology" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0013746
name: abnormal parotid intralobular duct morphology
def: "any structural anomaly of any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003452 ! abnormal parotid gland morphology
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0013747
name: abnormal parotid intercalated duct morphology
def: "any structural anomaly of the small intralobular tubular canal that leads directly from the serous acinus of the parotid gland to a striated (secretory) duct; in mouse, the intercalated ducts are short and narrow and are lined by low cuboidal epithelial cells with large central nuclei; they secrete bicarbonate ion into and absorb chloride ion from the acinar product" [http://courseweb.edteched.uottawa.ca/medicine-histology/English/Gastrointestinal/Salivary.htm, http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, http://en.wikipedia.org/wiki/Intercalated_duct, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal parotid intercalary duct morphology" EXACT []
is_a: MP:0013746 ! abnormal parotid intralobular duct morphology

[Term]
id: MP:0013748
name: abnormal parotid striated duct morphology
def: "any structural anomaly of the intralobular secretory duct of the parotid gland which connects an intercalated duct to an interlobular excretory duct; striated ducts are lined by cuboidal to columnar acidophilic cells and are so-named because of characteristic striations in the basal portions of the cells which are due to the alignment of mitochondria between deep infoldings of the basal cell membrane; the nucleus is in the central part of the cell above the striations; as they approach the excretory ducts, their diameter may exceed that of the acini; striated ducts reabsorb sodium and secrete potassium" [http://courseweb.edteched.uottawa.ca/medicine-histology/English/Gastrointestinal/Salivary.htm, http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, http://en.wikipedia.org/wiki/Striated_duct]
synonym: "abnormal parotid secretory duct morphology" EXACT []
is_a: MP:0013746 ! abnormal parotid intralobular duct morphology

[Term]
id: MP:0013749
name: abnormal parotid interlobular duct morphology
def: "any structural anomaly of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules" [http://courseweb.edteched.uottawa.ca/medicine-histology/English/Gastrointestinal/Salivary.htm, http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html]
is_a: MP:0013750 ! abnormal parotid excretory duct morphology

[Term]
id: MP:0013750
name: abnormal parotid excretory duct morphology
def: "any structural anomaly of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product" [http://courseweb.edteched.uottawa.ca/medicine-histology/English/Gastrointestinal/Salivary.htm, http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html]
is_a: MP:0003452 ! abnormal parotid gland morphology
is_a: MP:0009517 ! abnormal salivary gland duct morphology

[Term]
id: MP:0013751
name: increased cystadenoma incidence
def: "greater than the expected number of a histologically benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed, occurring in a specific population in a given time period; in some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic" [http://medical-dictionary.thefreedictionary.com/cystoadenoma, https://orcid.org/0000-0002-6490-7723]
synonym: "increased cystoadenoma incidence" EXACT []
is_a: MP:0010383 ! increased adenoma incidence

[Term]
id: MP:0013752
name: stridor
def: "a high-pitched breath sound resulting from turbulent air flow in the larynx or lower in the bronchial tree; it should not to be confused with stertor which is a noise originating in the pharynx; stridor is a physical sign which is caused by a narrowed or obstructed airway; it can be inspiratory, expiratory or biphasic, although it is usually heard during inspiration" [http://en.wikipedia.org/wiki/Stridor, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001950 ! abnormal respiratory sounds

[Term]
id: MP:0013753
name: tracheomalacia
def: "a condition characterized by flaccidity of the tracheal support cartilage which leads to tracheal collapse especially when increased airflow is demanded; the trachea normally dilates slightly during inspiration and narrows slightly during expiration; these processes are exaggerated in tracheomalacia, leading to airway collapse on expiration; the usual symptom of tracheomalacia is expiratory stridor or laryngeal crow" [http://en.wikipedia.org/wiki/Tracheomalacia, https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0031306 ! abnormal cartilage physiology

[Term]
id: MP:0013754
name: abnormal ocular surface morphology
def: "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4]
synonym: "abnormal eye surface morphology" EXACT []
synonym: "abnormal eye surface region morphology" EXACT []
synonym: "abnormal ocular surface region morphology" EXACT []
is_a: MP:0002092 ! abnormal eye morphology

[Term]
id: MP:0013755
name: abnormal intestinal phytosterol absorption
def: "any anomaly in the process in which phytosterols are taken up from the contents of the intestine; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [GO:0060752, https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intestinal plant sterol absorption" EXACT []
is_a: MP:0005342 ! abnormal intestinal lipid absorption

[Term]
id: MP:0013756
name: increased intestinal phytosterol absorption
def: "increased ability to take up phytosterols from the contents of the intestine; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [GO:0060752, https://orcid.org/0000-0003-3691-0324]
synonym: "increased intestinal plant sterol absorption" EXACT []
is_a: MP:0013755 ! abnormal intestinal phytosterol absorption

[Term]
id: MP:0013757
name: decreased intestinal phytosterol absorption
def: "reduced ability to take up phytosterols from the contents of the intestine; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [GO:0060752, https://orcid.org/0000-0003-3691-0324]
synonym: "decreased intestinal plant sterol absorption" EXACT []
synonym: "reduced intestinal phytosterol absorption" EXACT []
synonym: "reduced intestinal plant sterol absorption" EXACT []
is_a: MP:0013755 ! abnormal intestinal phytosterol absorption

[Term]
id: MP:0013758
name: increased intestinal glucose absorption
def: "increased ability of the small intestine to absorb glucose into the bloodstream" [GO:0001951, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001669 ! abnormal intestinal glucose absorption

[Term]
id: MP:0013759
name: decreased intestinal glucose absorption
def: "reduced ability of the small intestine to absorb glucose into the bloodstream" [GO:0001951, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001669 ! abnormal intestinal glucose absorption

[Term]
id: MP:0013760
name: abnormal T-helper cell morphology
def: "any structural anomaly of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
synonym: "abnormal helper T cell morphology" EXACT []
synonym: "abnormal helper T lymphocyte morphology" EXACT []
synonym: "abnormal helper T-cell morphology" EXACT []
synonym: "abnormal helper T-lymphocyte morphology" EXACT []
is_a: MP:0002435 ! abnormal effector T cell morphology

[Term]
id: MP:0013761
name: abnormal T-helper cell number
def: "anomaly in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
synonym: "abnormal helper T cell number" EXACT []
synonym: "abnormal helper T lymphocyte number" EXACT []
synonym: "abnormal helper T-cell number" EXACT []
synonym: "abnormal helper T-lymphocyte number" EXACT []
is_a: MP:0013760 ! abnormal T-helper cell morphology
is_a: MP:0013762 ! abnormal effector T cell number

[Term]
id: MP:0013762
name: abnormal effector T cell number
def: "anomaly in the number of differentiated T cells which have the ability to traffic to peripheral tissues and are capable of mounting a specific immune response" [CL:0000911]
is_a: MP:0002435 ! abnormal effector T cell morphology
is_a: MP:0006387 ! abnormal T cell number

[Term]
id: MP:0013763
name: increased T-helper cell number
def: "increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
synonym: "increased helper T cell number" EXACT []
synonym: "increased helper T lymphocyte number" EXACT []
synonym: "increased helper T-cell number" EXACT []
synonym: "increased helper T-lymphocyte number" EXACT []
is_a: MP:0005015 ! increased T cell number
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0013764
name: decreased T-helper cell number
def: "reduction in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
synonym: "decreased helper T cell number" EXACT []
synonym: "decreased helper T lymphocyte number" EXACT []
synonym: "decreased helper T-cell number" EXACT []
synonym: "decreased helper T-lymphocyte number" EXACT []
is_a: MP:0005018 ! decreased T cell number
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0013765
name: iris hyperplasia
def: "increase in the number of normal cells in normal arrangement in the iris, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic iris" EXACT []
is_a: MP:0001322 ! abnormal iris morphology

[Term]
id: MP:0013766
name: absent palatal rugae
def: "absence of the transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [https://orcid.org/0000-0002-6490-7723, PMID:19087265]
synonym: "absent impressiones rugales" EXACT []
synonym: "absent palatal ridge" EXACT []
synonym: "absent palatine fold" EXACT []
synonym: "absent palatine rugae" EXACT []
synonym: "absent plica palatina transversa" EXACT []
synonym: "absent plica palatinae transversae" EXACT []
synonym: "absent plicae palatinae transversae" EXACT []
synonym: "absent ruga of palate" EXACT []
synonym: "absent ruga palatina" EXACT []
synonym: "absent rugae of palate" EXACT []
synonym: "absent rugae palatinae" EXACT []
synonym: "absent transverse palatine fold" EXACT []
synonym: "absent transverse palatine folds set" EXACT []
synonym: "absent transverse palatine ridge" EXACT []
is_a: MP:0009652 ! abnormal palatal rugae morphology

[Term]
id: MP:0013767
name: decreased palatal rugae number
def: "reduced number of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species" [https://orcid.org/0000-0002-6490-7723, PMID:19087265]
synonym: "decreased impressiones rugales number" EXACT []
synonym: "decreased palatal ridge number" EXACT []
synonym: "decreased palatine fold number" EXACT []
synonym: "decreased palatine rugae number" EXACT []
synonym: "decreased plica palatina transversa number" EXACT []
synonym: "decreased plica palatinae transversae number" EXACT []
synonym: "decreased plicae palatinae transversae number" EXACT []
synonym: "decreased ruga of palate number" EXACT []
synonym: "decreased ruga palatina number" EXACT []
synonym: "decreased rugae of palate number" EXACT []
synonym: "decreased rugae palatinae number" EXACT []
synonym: "decreased transverse palatine fold number" EXACT []
synonym: "decreased transverse palatine folds set" EXACT []
synonym: "decreased transverse palatine ridge number" EXACT []
is_a: MP:0009652 ! abnormal palatal rugae morphology

[Term]
id: MP:0013768
name: decreased marginal zone precursor B cell number
def: "reduction in the number of CD23-positive, CD21-positive B cells in the marginal zone of lymphoid tissues" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced marginal zone precursor B cell number" EXACT []
is_a: MP:0008211 ! decreased mature B cell number

[Term]
id: MP:0013769
name: increased marginal zone precursor B cell number
def: "increase in the number of CD23-positive, CD21-positive B cells in the marginal zone of lymphoid tissues" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0008210 ! increased mature B cell number

[Term]
id: MP:0013770
name: abnormal effector memory T-helper cell number
def: "anomaly in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0013771
name: decreased effector memory T-helper cell number
def: "reduction in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced memory T-helper cell number" EXACT []
is_a: MP:0013770 ! abnormal effector memory T-helper cell number

[Term]
id: MP:0013772
name: increased effector memory T-helper cell number
def: "increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013770 ! abnormal effector memory T-helper cell number

[Term]
id: MP:0013773
name: abnormal KLRG1-positive T-helper cell number
def: "anomaly in the number of CD4-positive alpha-beta T-helper cells expressing KLRG1, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013761 ! abnormal T-helper cell number

[Term]
id: MP:0013774
name: decreased KLRG1-positive T-helper cell number
def: "reduction in the number of CD4-positive alpha-beta T-helper cells expressing KLRG1, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
synonym: "reduced KLRG1-positive T-helper cell number" EXACT []
is_a: MP:0013773 ! abnormal KLRG1-positive T-helper cell number

[Term]
id: MP:0013775
name: increased KLRG1-positive T-helper cell number
def: "increase in the number of CD4-positive alpha-beta T-helper cells expressing KLRG1, a marker associated with activation" [https://orcid.org/0000-0002-6181-4695]
is_a: MP:0013773 ! abnormal KLRG1-positive T-helper cell number

[Term]
id: MP:0013776
name: bone marrow failure
def: "inherited or acquired dysfunction of hematopoietic stem cells that can result in abnormalities in one or more of the stem cell lineages (erythroid, myeloid, megakaryocytic)" [http://emedicine.medscape.com/article/199003-overview, MGI:llw2]
is_a: MP:0000168 ! abnormal bone marrow development
is_a: MP:0010763 ! abnormal hematopoietic stem cell physiology

[Term]
id: MP:0013777
name: spontaneous remission from bone marrow failure
def: "a lessening of symptoms or intensity of disease due to bone marrow failure that occurs without treatment and may be temporary or permanent" [MGI:llw2]
is_a: MP:0013776 ! bone marrow failure

[Term]
id: MP:0013778
name: abnormal mammary gland myoepithelium morphology
def: "any structural anomaly of the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane; basal cells (aka myoepithelial cells) are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; in lactating females, milk is produced by luminal cells, secreted into the alveolar lumen and collected in the ducts for expulsion out of the body through the nipple, due to the contractile activity of the basal myoepithelial cells" [https://orcid.org/0000-0002-6490-7723, ISBN:8793237073]
synonym: "abnormal mammary epithelium basal cell layer morphology" EXACT []
synonym: "abnormal mammary epithelium basal cell morphology" EXACT []
synonym: "abnormal mammary MEC morphology" EXACT []
synonym: "abnormal mammary myoepithelial cell morphology" EXACT []
synonym: "abnormal mammary myoepithelium morphology" EXACT []
is_a: MP:0009504 ! abnormal mammary gland epithelium morphology

[Term]
id: MP:0013779
name: abnormal mammary gland myoepithelium physiology
def: "any functional anomaly of the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane; basal cells (aka myoepithelial cells or MECs) are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; during lactation, MECs contract in response to oxytocin to generate the contractile force required for milk ejection; MECs are involved in all developmental stages of mammary gland morphogenesis, modulating proliferation and differentiation of luminal cells; they take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors; in addition, MECs are regarded as natural cancer suppressors: they secrete suppressor proteins limiting cancer growth, invasiveness, and neoangiogenesis; MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neighboring luminal cells" [ISBN:8793237073, PMID:20235044]
synonym: "abnormal mammary epithelium basal cell layer physiology" EXACT []
synonym: "abnormal mammary epithelium basal cell physiology" EXACT []
synonym: "abnormal mammary MEC physiology" EXACT []
synonym: "abnormal mammary myoepithelial cell physiology" EXACT []
synonym: "abnormal mammary myoepithelium physiology" EXACT []
is_a: MP:0010172 ! abnormal mammary gland epithelium physiology

[Term]
id: MP:0013780
name: decreased mammary myoepithelial cell contraction
def: "reduced ability of the mammary myoepithelial cells to contract in response to oxytocin and generate the contractile force required for successful milk ejection and lactation" [https://orcid.org/0000-0002-6490-7723, ISBN:8793237073, PMID:20235044]
synonym: "decreased mammary epithelium basal cell contractility" EXACT []
synonym: "decreased mammary epithelium basal cell contraction" EXACT []
synonym: "decreased mammary myoepithelial cell contractility" EXACT []
synonym: "impaired mammary myoepithelial cell contraction" EXACT []
synonym: "reduced mammary epithelium basal cell contractility" EXACT []
synonym: "reduced mammary epithelium basal cell contraction" EXACT []
synonym: "reduced mammary myoepithelial cell contractility" EXACT []
synonym: "reduced mammary myoepithelial cell contraction" EXACT []
is_a: MP:0013779 ! abnormal mammary gland myoepithelium physiology

[Term]
id: MP:0013781
name: abnormal mammary gland luminal epithelium morphology
def: "any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, https://orcid.org/0000-0002-6490-7723, ISBN:8793237073]
is_a: MP:0009504 ! abnormal mammary gland epithelium morphology

[Term]
id: MP:0013782
name: abnormal mammary duct terminal end bud morphology
def: "any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [https://orcid.org/0000-0002-6490-7723, PMID:16280048, PMID:16916375, PMID:18296651]
synonym: "abnormal mammary duct TEB morphology" EXACT []
is_a: MP:0009503 ! abnormal mammary gland duct morphology

[Term]
id: MP:0013783
name: absent mammary duct terminal end bud
def: "failure to develop or maintain the unique club-shaped epithelial structure normally formed at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; normally, TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed; absence of TEBs is often associated with reduced ductal outgrowth and impaired branching morphogenesis" [https://orcid.org/0000-0002-6490-7723, PMID:16280048, PMID:16916375, PMID:18296651]
synonym: "absent mammary duct TEB" EXACT []
is_a: MP:0031174 ! decreased mammary duct terminal end bud number

[Term]
id: MP:0013784
name: abnormal mammary gland bud elongation
def: "any anomaly in the process in which a mammary bud grows along its axis; in mouse embryos, the distal end of the mammary bud begins to elongate into the underlying dermal mesenchyme to form a mammary cord (sprout) by E15.5" [https://orcid.org/0000-0002-6490-7723, PMID:25467960]
is_a: MP:0004135 ! abnormal mammary gland embryonic development

[Term]
id: MP:0013785
name: abnormal mammary gland bud morphology
def: "any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is elevated above the surrounding ectoderm as a knob or dome; at E13.5, the buds sink into the underlying dermal mesenchyme, and by E14.5 they can no longer be detected externally; in female mouse embryos, five pairs of anlagen or buds are formed along the mammary line between E12.5 and E14.5 by proliferation of basal epidermal cells; while further mammary development is temporarily arrested in females, androgen receptor activation in male embryos causes degeneration of the buds between E13.5 and E15.5; in female mice, further development is resumed at around E15.5 when each bud elongates to form a mammary cord (sprout), invading the underlying fat pad precursor" [http://www.informatics.jax.org/greenbook/frames/frame13.shtml, https://orcid.org/0000-0002-6490-7723, PMID:12558599]
comment: In male mouse embryos the bud separates from the epidermis by testosterone-dependent mechanisms between E14.5 and E15.5, and subsequently degenerates; male mice have no nipples and usually only four pairs of rudimentary glands consisting of branching ducts with no aveoli, primary ducts, or openings to the exterior.
synonym: "abnormal lactiferous gland bud morphology" EXACT []
synonym: "abnormal mammary bud morphology" EXACT []
synonym: "abnormal milk bud morphology" EXACT []
is_a: MP:0004135 ! abnormal mammary gland embryonic development

[Term]
id: MP:0013786
name: abnormal mammary gland bud formation
def: "any anomaly in the morphogenetic process in which a distinct bulb of epithelial cells forms from a mammary placode" [https://orcid.org/0000-0002-6490-7723, PMID:20484386]
comment: In mice, as the cells from the placode begin to invaginate into the underlying mesenchyme they pile up at the surface and begin to array themselves in a concentric orientation so that the early bud is elevated above the plane of the surrounding epidermis; as a result, at E12, the developing buds are visible as prominent knobs on the ventral surface of the embryo, which then submerge beneath the plane of the skin; the formation of the epithelial bud is accompanied by dramatic changes in the underlying mesenchyme; cells surrounding the epithelium elongate, condense, and orient their long axis in a radial fashion around the developing epithelial cells; at the end of this process, the mature bud consists of a sphere of concentrically arrayed epithelial cells connected to the skin surface by a stalk of epidermal-like cells; both ball and stalk are, in turn, surrounded by three to five layers of condensed mesenchyme, referred to as the primary mammary mesenchyme; in female mice the mammary buds remain relatively quiescent from E14 to E16, when ductal morphogenesis commences; in male mice, the mesenchyme around the stalk enlarges and condenses further, eventually severing the connection to the skin; this is followed by apoptosis of the mammary mesenchyme and many cells within the epithelial bud as well; consequently, male mice have either no mammary epithelial ducts or only very rudimentary ones.
synonym: "abnormal lactiferous gland bud formation" EXACT []
synonym: "abnormal mammary bud formation" EXACT []
synonym: "abnormal milk bud formation" EXACT []
is_a: MP:0004135 ! abnormal mammary gland embryonic development

[Term]
id: MP:0013787
name: photophobia
def: "abnormal aversion or avoidance behavior in response to light; photophobia is symptom of abnormal intolerance to visual perception of light; as a medical symptom, photophobia is not a morbid fear or phobia, but an experience of discomfort or pain to the eyes due to light exposure or by presence of actual physical sensitivity of the eyes" [http://en.wikipedia.org/wiki/Photophobia, https://orcid.org/0000-0002-6490-7723]
synonym: "avoidance of light" EXACT []
synonym: "light-aversive behavior" EXACT []
synonym: "light-aversive behaviour" EXACT []
is_a: MP:0001999 ! photosensitivity
is_a: MP:0011275 ! abnormal behavioral response to light

[Term]
id: MP:0013788
name: external nares atresia
def: "congenital blockage, fusion, or absence of the normal anterior openings to the nasal cavity; the naris may be closed by membrane, cartilage or, rarely, bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "anterior nares atresia" EXACT []
synonym: "nostril atresia" EXACT []
is_a: MP:0002235 ! abnormal external nares morphology

[Term]
id: MP:0013789
name: small external nares
def: "decreased size of the anterior openings to the nasal cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "small anterior nares" EXACT []
synonym: "small nostrils" EXACT []
is_a: MP:0002235 ! abnormal external nares morphology

[Term]
id: MP:0013790
name: single external naris
def: "presence of only one anterior opening to the nasal cavity as opposed to the normal two; usually associated with midline facial defects arising from cleavage anomalies" [https://orcid.org/0000-0002-6490-7723]
synonym: "mono nostril" EXACT []
synonym: "single anterior naris" EXACT []
synonym: "single nostril" EXACT []
is_a: MP:0002235 ! abnormal external nares morphology

[Term]
id: MP:0013791
name: absent external nares
def: "absence or failure to form both of the anterior openings to the nasal cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent anterior nares" EXACT []
synonym: "absent nostrils" EXACT []
is_a: MP:0002235 ! abnormal external nares morphology

[Term]
id: MP:0013792
name: abnormal small intestine goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [https://orcid.org/0000-0002-6490-7723, PMID:25872481]
synonym: "abnormal goblet cell of epithelium of small intestine morphology" EXACT []
synonym: "abnormal goblet cell of small intestine morphology" EXACT []
synonym: "abnormal small intestinal goblet cell morphology" EXACT []
is_a: MP:0003449 ! abnormal intestinal goblet cell morphology
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0013793
name: abnormal large intestine goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [https://orcid.org/0000-0002-6490-7723, PMID:25872481]
synonym: "abnormal goblet cell of epithelium of large intestine morphology" EXACT []
synonym: "abnormal large intestinal goblet cell morphology" EXACT []
is_a: MP:0003449 ! abnormal intestinal goblet cell morphology
is_a: MP:0004842 ! abnormal large intestine crypts of Lieberkuhn morphology

[Term]
id: MP:0013794
name: abnormal intestinal villus goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the villi of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
is_a: MP:0013792 ! abnormal small intestine goblet cell morphology

[Term]
id: MP:0013795
name: abnormal colon goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [https://orcid.org/0000-0002-6490-7723, PMID:25872481]
synonym: "abnormal colonic goblet cell morphology" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0013793 ! abnormal large intestine goblet cell morphology

[Term]
id: MP:0013796
name: abnormal duodenal goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the duodenum of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
synonym: "abnormal duodenum goblet cell morphology" EXACT []
is_a: MP:0013794 ! abnormal intestinal villus goblet cell morphology

[Term]
id: MP:0013797
name: abnormal ileal goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the ileum of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
synonym: "abnormal ileum goblet cell morphology" EXACT []
is_a: MP:0013794 ! abnormal intestinal villus goblet cell morphology

[Term]
id: MP:0013798
name: abnormal jeujunal goblet cell morphology
def: "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the jejunum of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
synonym: "abnormal jejunum goblet cell morphology" EXACT []
is_a: MP:0013794 ! abnormal intestinal villus goblet cell morphology

[Term]
id: MP:0013799
name: abnormal intestinal goblet cell physiology
def: "any functional anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; intestinal goblet cells produce a number of effector molecules including a range of mucins and antimicrobial proteins, such as trefoil factors and resistin-like molecules, which enable these to play a key part in innate defense mechanisms in the gut, against both bacterial and parasitic infections" [https://orcid.org/0000-0002-6490-7723, PMID:25872481]
is_a: MP:0005621 ! abnormal cell physiology
is_a: MP:0014201 ! abnormal intestinal epithelium physiology

[Term]
id: MP:0013800
name: abnormal pericardial fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue surrounding the cardiac tissue" [https://orcid.org/0000-0001-6624-9261, https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0013801
name: abnormal subscapular fat pad morphology
def: "any structural anomaly of the encapsulated adipose tissue located beneath the scapulae" [https://orcid.org/0000-0003-3691-0324, MPD:Bogue]
is_a: MP:0005334 ! abnormal fat pad morphology

[Term]
id: MP:0013802
name: abnormal IgG2 level
def: "deviation from the normal levels of the total immunoglobulin class G2 level" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0020174 ! abnormal IgG level

[Term]
id: MP:0013803
name: increased IgG2 level
def: "greater than normal immunoglobulin class G2 level" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0002493 ! increased IgG level
is_a: MP:0013802 ! abnormal IgG2 level

[Term]
id: MP:0013804
name: decreased IgG2 level
def: "less than normal immunoglobulin class G2 level" [https://orcid.org/0000-0003-4890-4685]
is_a: MP:0001805 ! decreased IgG level
is_a: MP:0013802 ! abnormal IgG2 level

[Term]
id: MP:0013805
name: myeloid metaplasia
def: "a progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow, and the marrow is replaced by fibrous (scar) tissue; may lead to anemia, enlarged spleen, the presence of nucleated red blood cells and immature granulocytes in the blood, and the occurrence of extramedullary hematopoiesis in the spleen and liver" [ISBN:0781727286]
is_a: MP:0001601 ! abnormal myelopoiesis

[Term]
id: MP:0013806
name: encephalopathy
def: "any diffuse disorder of the brain that alters brain function or structure" [HP:0001298, HPO:probinson]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0013807
name: generalized edema
def: "generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body" [HP:0007430, HPO:curators]
synonym: "generalized oedema" EXACT []
synonym: "generalized tissue edema" EXACT []
synonym: "generalized tissue oedema" EXACT []
is_a: MP:0001785 ! edema

[Term]
id: MP:0013808
name: abnormal tunnel of Corti morphology
def: "any structrual anomaly of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000042 ! abnormal organ of Corti morphology

[Term]
id: MP:0013809
name: absent pectinate muscle
def: "absence of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions" [ISBN:0-683-40008-8]
synonym: "absent pectinate fibers" EXACT []
synonym: "absent pectinate muscles" EXACT []
is_a: MP:0010496 ! abnormal pectinate muscle morphology

[Term]
id: MP:0013810
name: absent brachiocephalic trunk
def: "absence of the short first aortic arch branch which divides into the right subclavian artery and the right common carotid artery" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent brachiocephalic artery" EXACT []
synonym: "absent innominate artery" EXACT []
is_a: MP:0010663 ! abnormal brachiocephalic trunk morphology

[Term]
id: MP:0013811
name: abnormal orbital vein morphology
def: "any structural anomaly of the highly complex and variable set of veins that drain blood from the eye and supporting tissue, including the superior and inferior ophthalmic veins, the middle and medial ophthalmic veins, four collateral veins), variable orbital venous networks, and variable venous tributaries" [PMID:17019411]
synonym: "abnormal orbital veins morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0013812
name: enlarged orbital veins
def: "increased size of the highly complex and variable set of veins that drain blood from the eye and supporting tissue, including the superior and inferior ophthalmic veins, the middle and medial ophthalmic veins, four collateral veins), variable orbital venous networks, and variable venous tributaries" [PMID:17019411]
synonym: "enlarged orbit veins" EXACT []
synonym: "increased orbit veins size" EXACT []
synonym: "increased orbital veins size" EXACT []
is_a: MP:0013811 ! abnormal orbital vein morphology

[Term]
id: MP:0013813
name: dilated hepatic portal vein
def: "an expansion in the lumen volume of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, which then divides into the right and left branches which ramify with the liver" [ISBN:0-683-40008-8]
synonym: "dilated hepatic portal veins" EXACT []
synonym: "dilated HPV" EXACT []
synonym: "dilated portal vein" EXACT []
synonym: "dilated portal veins" EXACT []
synonym: "hepatic portal vein dilation" EXACT []
synonym: "HPV dilation" EXACT []
synonym: "portal vein dilation" EXACT []
is_a: MP:0004938 ! dilated vasculature
is_a: MP:0010668 ! abnormal hepatic portal vein morphology

[Term]
id: MP:0013814
name: abnormal hepatic portal vein connection
def: "any anomaly of the connection site of the right or left branch of the hepatic portal vein to the liver" [ISBN:0-683-40008-8]
synonym: "abnormal portal vein attachment" EXACT []
is_a: MP:0010668 ! abnormal hepatic portal vein morphology

[Term]
id: MP:0013815
name: abnormal digastric muscle morphology
def: "any structural anomaly of the small suprahyoid muscle located below the body of the mandible, and extending, in a curved form, from the mastoid notch to the symphysis menti; it consists of two muscular bellies, an anterior and a posterior belly, united by an intermediate rounded tendon attaching to the hyoid bone through a fibrous loop; the two bellies have different embryological origins and are supplied by different cranial nerves" [https://en.wikipedia.org/wiki/Digastric_muscle, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal digastricus morphology" EXACT []
is_a: MP:0030240 ! abnormal suprahyoid muscle morphology

[Term]
id: MP:0013816
name: absent digastric muscle
def: "absence of the small suprahyoid muscle located below the body of the mandible, and extending, in a curved form, from the mastoid notch to the symphysis menti; it consists of an anterior and a posterior belly, united by an intermediate rounded tendon attaching to the hyoid bone through a fibrous loop" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent digastricus muscle" EXACT []
is_a: MP:0013815 ! abnormal digastric muscle morphology

[Term]
id: MP:0013817
name: absent nasal cavity
def: "absence of the cavity of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [MESH:A04.531.449]
synonym: "absent cavity of nose" EXACT []
synonym: "absent cavity of olfactory apparatus" EXACT []
synonym: "absent nasal canal" EXACT []
synonym: "absent nasal conduit space" EXACT []
synonym: "absent nasal fossa" EXACT []
synonym: "absent olfactory chamber cavity" EXACT []
is_a: MP:0002237 ! abnormal nasal cavity morphology

[Term]
id: MP:0013818
name: abnormal oral cavity morphology
def: "any structural anomaly of the anatomical cavity at the start of the digestive tract that is enclosed by the mouth" [UBERON:0000167]
synonym: "abnormal buccal cavity morphology" EXACT []
synonym: "abnormal cavity of mouth morphology" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology

[Term]
id: MP:0013819
name: abnormal acromioclavicular joint morphology
def: "any structural anomaly of any joint connecting the acromonion of the scapula and clavicle" [UBERON:0003692]
is_a: MP:0030816 ! abnormal shoulder joint morphology
is_a: MP:0030820 ! abnormal pectoral girdle joint morphology

[Term]
id: MP:0013820
name: absent optic cup
def: "absence of the double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent eye cup" EXACT []
synonym: "absent eyecup" EXACT []
synonym: "absent ocular cup" EXACT []
synonym: "absent ophtalmic cup" EXACT []
is_a: MP:0004269 ! abnormal optic cup morphology

[Term]
id: MP:0013821
name: abnormal cerebral artery morphology
def: "any structural anomaly of any of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain" [UBERON:0004449]
is_a: MP:0004950 ! abnormal brain vasculature morphology
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0013822
name: abnormal anterior cerebral artery morphology
def: "any structural anomaly of a pair of arteries on the brain that supply oxygen to most medial portions of frontal lobes and superior medial parietal lobes; the anterior cerebral arteries arise from the internal carotid artery and are part of the Circle of Willis" [UBERON:0001624]
synonym: "abnormal cerebral anterior artery morphology" EXACT []
is_a: MP:0013821 ! abnormal cerebral artery morphology

[Term]
id: MP:0013823
name: absent segment of anterior cerebral artery
def: "absence of a portion of a pair of arteries on the brain that supply oxygen to most medial portions of frontal lobes and superior medial parietal lobes" [https://orcid.org/0000-0003-3691-0324, UBERON:0001624]
is_a: MP:0013822 ! abnormal anterior cerebral artery morphology

[Term]
id: MP:0013824
name: abnormal hypoglossal canal morphology
def: "any structural anomaly of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]
synonym: "abnormal anterior condylar canal morphology" EXACT []
synonym: "abnormal anterior condyloid canal of occipital bone morphology" EXACT []
synonym: "abnormal anterior condyloid foramen morphology" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology
is_a: MP:0030309 ! abnormal posterior cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology

[Term]
id: MP:0013825
name: small hypoglossal canal
def: "reduced size of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]
synonym: "decreased hypoglossal canal size" EXACT []
synonym: "reduced hypoglossal canal size" EXACT []
synonym: "small anterior condylar canal" EXACT []
synonym: "small anterior condyloid foramen" EXACT []
is_a: MP:0013824 ! abnormal hypoglossal canal morphology

[Term]
id: MP:0013826
name: absent hypoglossal canal
def: "absence of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]
synonym: "absence of hypoglossal canal" EXACT []
synonym: "absent anterior condylar canal" EXACT []
synonym: "absent anterior condyloid foramen" EXACT []
is_a: MP:0013824 ! abnormal hypoglossal canal morphology

[Term]
id: MP:0013827
name: thin oculomotor nerve
def: "slender appearance of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye" [ISBN:0-683-40008-8]
synonym: "thin CN-III" EXACT []
is_a: MP:0001061 ! abnormal oculomotor nerve morphology

[Term]
id: MP:0013828
name: thin facial nerve
def: "a slender apperance of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [ISBN:0-683-40008-8]
synonym: "thin CN-VII" EXACT []
is_a: MP:0001071 ! abnormal facial nerve morphology

[Term]
id: MP:0013829
name: thin splanchnic nerve
def: "slender appearance of the major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord, which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses, and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia" [MESH:A08.800.050.050.800]
is_a: MP:0008318 ! abnormal splanchnic nerve morphology

[Term]
id: MP:0013830
name: abnormal intrathoracic topology of vagus nerve
def: "abnormal position of the vagus nerve in the intrathoracic region" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal intrathoracic position of vagus nerve" EXACT []
is_a: MP:0013837 ! abnormal vagus nerve topology

[Term]
id: MP:0013831
name: vagus nerve compression
def: "a flattened or pressed appearance of the vagus nerve as if by applied pressure" [https://orcid.org/0000-0003-3691-0324]
synonym: "CN-X compression" EXACT []
synonym: "compressed CN-X" EXACT []
synonym: "vagal nerve compression" EXACT []
is_a: MP:0001074 ! abnormal vagus nerve morphology

[Term]
id: MP:0013832
name: thin vagus nerve
def: "slender appearance of the autonomic, sensory and motor axons of the tenth cranial nerve" [ISBN:0838580343]
synonym: "thin CN-X" EXACT []
synonym: "thin vagal nerve" EXACT []
is_a: MP:0001074 ! abnormal vagus nerve morphology

[Term]
id: MP:0013833
name: absent olfactory nerve
def: "absence of the first cranial nerve, which conveys the sense of smell" [MESH:A08.800.800.120.640]
synonym: "absent CN-I" EXACT []
is_a: MP:0005236 ! abnormal olfactory nerve morphology

[Term]
id: MP:0013834
name: thin hypoglossal nerve
def: "slender appearance of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]
synonym: "thin CN-XII" EXACT []
is_a: MP:0001076 ! abnormal hypoglossal nerve morphology

[Term]
id: MP:0013835
name: absent hypoglossal nerve
def: "absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]
synonym: "absent CN-XII" EXACT []
is_a: MP:0001076 ! abnormal hypoglossal nerve morphology

[Term]
id: MP:0013836
name: abnormal hypoglossal nerve topology
def: "abnormal position of the hypoglossal nerve" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CN-XII position" EXACT []
synonym: "abnormal hypoglossal nerve position" EXACT []
is_a: MP:0001076 ! abnormal hypoglossal nerve morphology

[Term]
id: MP:0013837
name: abnormal vagus nerve topology
def: "abnormal position of the vagus nerve" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal CN-X topology" EXACT []
synonym: "abnormal vagal nerve position" EXACT []
synonym: "abnormal vagus nerve position" EXACT []
is_a: MP:0001074 ! abnormal vagus nerve morphology

[Term]
id: MP:0013838
name: small caudate nucleus
def: "decreased size of one or both C-shaped structures that border the lateral ventricle and contain input neurons involved with control of voluntary movement in the brain" [ISBN:0-683-40008-8, ISBN:0838580343]
synonym: "decreased caudate nucelus size" EXACT []
synonym: "reduced caudate nucelus size" EXACT []
is_a: MP:0004078 ! abnormal caudate nucleus morphology

[Term]
id: MP:0013839
name: abnormal posterior cerebral artery morphology
def: "any structural anomaly of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain; it arises near the intersection of the posterior communicating artery and the basilar artery and connects with the ipsilateral middle cerebral artery (MCA) and internal carotid artery via the posterior communicating artery" [UBERON:0001636]
is_a: MP:0013821 ! abnormal cerebral artery morphology

[Term]
id: MP:0013840
name: absent segment of posterior cerebral artery
def: "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]
synonym: "absent posterior cerebral artery segment" EXACT []
is_a: MP:0013839 ! abnormal posterior cerebral artery morphology

[Term]
id: MP:0013841
name: abnormal lymphatic vessel topology
def: "abnormal position of any component of the network of vessels that carries lymph around the body" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal lymph vessel position" EXACT []
synonym: "abnormal lymph vessel topology" EXACT []
synonym: "abnormal lymphatic vessel position" EXACT []
synonym: "abnormal topology of lymph vessels" EXACT []
is_a: MP:0001879 ! abnormal lymphatic vessel morphology

[Term]
id: MP:0013842
name: ductus venosus stenosis
def: "abnormal narrowing or constriction of the lumen of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [https://orcid.org/0000-0003-3691-0324]
synonym: "narrowing of ductus venosus" EXACT []
is_a: MP:0013873 ! abnormal ductus venosus morphology
is_a: MP:0031477 ! vein stenosis

[Term]
id: MP:0013843
name: hepatic portal vein stenosis
def: "abnormal narrowing or constriction of the lumen of the hepatic portal vein" [ISBN:0-683-40008-8]
synonym: "narrowing of portal vein" EXACT []
synonym: "portal vein stenosis" EXACT []
is_a: MP:0010668 ! abnormal hepatic portal vein morphology
is_a: MP:0031477 ! vein stenosis

[Term]
id: MP:0013844
name: abnormal perichondrial ossification
def: "formation of bone in the perichondrium, which is normally cartilaginous" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal perichondrium ossification" EXACT []
is_a: MP:0006322 ! abnormal perichondrium morphology

[Term]
id: MP:0013845
name: abnormal eye muscle topology
def: "abnormal position of eye muscles" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal eye muscle position" EXACT []
is_a: MP:0003686 ! abnormal eye muscle morphology

[Term]
id: MP:0013846
name: retropharyngeal edema
def: "accumulation of watery or serous fluid in the retropharyngeal space" [https://orcid.org/0000-0003-3691-0324]
synonym: "retropharyngeal oedema" EXACT []
is_a: MP:0001785 ! edema

[Term]
id: MP:0013847
name: retropleural edema
def: "accumulation of watery or serous fluid in the retropleural space" [https://orcid.org/0000-0003-3691-0324]
synonym: "retropleural oedema" EXACT []
is_a: MP:0001785 ! edema

[Term]
id: MP:0013848
name: subcutaneous edema
def: "accumulation of watery or serous fluid in the subcutaneous region below the skin" [https://orcid.org/0000-0003-3691-0324]
synonym: "subcutaneous oedema" EXACT []
is_a: MP:0001785 ! edema
is_a: MP:0003705 ! abnormal hypodermis morphology

[Term]
id: MP:0013849
name: absent abducens nerve
def: "absence of the sixth cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [MESH:A08.800.800.120.030]
synonym: "absent CN-VI" EXACT []
is_a: MP:0001070 ! abnormal abducens nerve morphology

[Term]
id: MP:0013850
name: absent posterior commissure
def: "absence of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei" [ISBN:0-683-40008-8]
synonym: "absent epithalamic commissure" EXACT []
is_a: MP:0010893 ! abnormal posterior commissure morphology

[Term]
id: MP:0013851
name: abnormal Wolffian duct topology
def: "aberrant postition of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [ISBN:0-683-40008-8]
synonym: "abnormal Gartner's duct topology" EXACT []
synonym: "abnormal Leydig's duct topology" EXACT []
synonym: "abnormal mesonephric duct position" EXACT []
synonym: "abnormal Wollfian duct position" EXACT []
is_a: MP:0003827 ! abnormal Wolffian duct morphology

[Term]
id: MP:0013852
name: abnormal Mullerian duct topology
def: "aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]
synonym: "abnormal paramesonephric duct topology" EXACT []
is_a: MP:0003826 ! abnormal Mullerian duct morphology

[Term]
id: MP:0013853
name: abnormal hepatic portal vein formation
def: "aberrant formation of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver" [ISBN:0-683-40008-8]
synonym: "abnormal HPV formation" EXACT []
synonym: "abnormal portal vein formation" EXACT []
synonym: "abnormal PV formation" EXACT []
is_a: MP:0010668 ! abnormal hepatic portal vein morphology

[Term]
id: MP:0013854
name: abnormal celiac artery morphology
def: "any structural anomaly of the short, thick trunk which arises from the front of the abdominal aorta immediately below the aortic opening in the diaphragm; it lies below the liver and on the upper border of the pancreas and branches into the left gastric, hepatic, and splenic arteries" [ISBN:0-683-40008-8]
synonym: "abnormal celiac trunk morphology" EXACT []
synonym: "abnormal coeliac artery morphology" EXACT []
synonym: "abnormal coeliac trunk morphology" EXACT []
synonym: "abnormal coeliaco-mesenteric trunk morphology" EXACT []
synonym: "abnormal Haller's tripus morphology" EXACT []
synonym: "abnormal truncus coeliacus morphology" EXACT []
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0013855
name: absent celiac artery
def: "absence of the short, thick trunk which arises from the front of the abdominal aorta immediately below the aortic opening in the diaphragm" [ISBN:0-683-40008-8]
synonym: "absent celiac trunk" EXACT []
synonym: "absent coeliac artery" EXACT []
synonym: "absent coeliac trunk" EXACT []
synonym: "absent coeliaco-mesenteric trunk" EXACT []
synonym: "absent Haller's tripus" EXACT []
is_a: MP:0013854 ! abnormal celiac artery morphology

[Term]
id: MP:0013856
name: celiac artery compression
def: "increased pressure exerted on the celiac artery by the median arcuate ligament of the diaphragm" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "celiac trunk compression" EXACT []
synonym: "coeliac artery compression" EXACT []
synonym: "coeliac trunk compression" EXACT []
synonym: "coeliaco-mesenteric trunk compression" EXACT []
synonym: "truncus coeliacus compression" EXACT []
is_a: MP:0013854 ! abnormal celiac artery morphology

[Term]
id: MP:0013857
name: abnormal abdominal muscle morphology
def: "any structural anomaly of a muscle that is part of the abdomen" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000759 ! abnormal skeletal muscle morphology

[Term]
id: MP:0013858
name: abnormal azygos vein topology
def: "abnormal position(s) of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vena azygos topology" EXACT []
is_a: MP:0011569 ! abnormal azygos vein morphology

[Term]
id: MP:0013859
name: abnormal vitelline vein connection
def: "aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [https://orcid.org/0000-0003-3691-0324, ISBN:0-683-40008-8]
synonym: "abnormal connection of vitelline vein" EXACT []
is_a: MP:0010666 ! abnormal vitelline vein morphology

[Term]
id: MP:0013860
name: anastomosis between common carotid and vertebral artery
def: "abnormal communication between the common carotid and the vertebral artery by means of collateral channels, often occurring when the common carotid or the vertebral artery are obstructed" [ISBN:0-683-40008-8]
is_a: MP:0011513 ! abnormal vertebral artery morphology
is_a: MP:0012729 ! abnormal common carotid artery morphology

[Term]
id: MP:0013861
name: abnormal pancreas topology
def: "abnormal postion of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ISBN:0-683-40008-8]
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0013862
name: abnormal cecum position
def: "abnormal placement of the large sac normally located at the ileum and large intestine junction" [ISBN:0-683-40008-8]
synonym: "abnormal caecum position" EXACT []
synonym: "abnormal position of caecum" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology
is_a: MP:0003284 ! abnormal large intestine placement

[Term]
id: MP:0013863
name: abnormal paraumbilical vein morphology
def: "any structural anomaly of one or more of small superficial veins that run from the umbilicus along the round ligament of the liver and terminate as accessory portal veins in the liver; these are susceptible to varicosity during portal hypertension" [ISBN:0-683-40008-8, PMID:7400038]
synonym: "abnormal venae paraumbilicales morphology" EXACT []
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0013864
name: enlarged paraumbilical vein
def: "increased size of one or more of small superficial veins that run from the umbilicus along the round ligament of the liver and terminate as accessory portal veins in the liver" [ISBN:0-683-40008-8, PMID:7400038]
synonym: "enlarged venae paraumbilicales" EXACT []
synonym: "increased paraumbilical vein size" EXACT []
is_a: MP:0013863 ! abnormal paraumbilical vein morphology

[Term]
id: MP:0013865
name: abnormal dorsal pancreas topology
def: "aberrant location or orientation of the transient embryonic structure that fuses with the ventral pancreas during development to form a single organ" [PMID:23909279]
synonym: "abnormal dorsal pancreatic bud topology" EXACT []
is_a: MP:0013861 ! abnormal pancreas topology
is_a: MP:0013866 ! abnormal dorsal pancreas morphology

[Term]
id: MP:0013866
name: abnormal dorsal pancreas morphology
def: "any structural anomaly of the transient embryonic structure that fuses with the ventral pancreas during development to form a single organ; the dorsal pancreatic bud gives rise to the body, tail, and isthmus of the pancreas" [PMID:23909279]
synonym: "abnormal dorsal pancreatic anlagen morphology" EXACT []
synonym: "abnormal dorsal pancreatic bud morphology" EXACT []
is_a: MP:0003934 ! abnormal pancreas development

[Term]
id: MP:0013867
name: abnormal ventral pancreas morphology
def: "any structural anomaly of the transient embryonic structure that fuses with the dorsal pancreas during development to form a single organ; the ventral pancreatic bud gives rise to the pancreatic head and uncinate process" [PMID:23909279]
synonym: "abnormal ventral pancreatic anlage morphology" EXACT []
synonym: "abnormal ventral pancreatic bud morphology" EXACT []
is_a: MP:0003934 ! abnormal pancreas development

[Term]
id: MP:0013868
name: abnormal ventral pancreas topology
def: "abnormal location or orientation of the transient embryonic structure that fuses with the dorsal pancreas during development to form a single organ" [PMID:23909279]
synonym: "abnormal ventral pancreatic bud topology" EXACT []
is_a: MP:0013861 ! abnormal pancreas topology
is_a: MP:0013867 ! abnormal ventral pancreas morphology

[Term]
id: MP:0013869
name: vascular diverticulum
def: "a pouch or sac opening from the lumen of a vessel" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0013870
name: absent proximal internal carotid artery segment
is_a: MP:0012730 ! abnormal internal carotid artery morphology

[Term]
id: MP:0013871
name: abnormal stapedial artery topology
def: "abnormal location or orientation of the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004665 ! abnormal stapedial artery morphology

[Term]
id: MP:0013872
name: abnormal jugular vein morphology
def: "any structural anomaly of any of the veins that bring deoxygenated blood from the head back to the heart via the superior vena cava" [ISBN:0-683-40008-8, UBERON:0004711]
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0013873
name: abnormal ductus venosus morphology
def: "any structural anomaly of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0013874
name: abnormal ductus venosus topology
def: "aberrant position or orientation of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal ductus venosus position" EXACT []
is_a: MP:0013873 ! abnormal ductus venosus morphology

[Term]
id: MP:0013875
name: increased trigeminal neuroma incidence
def: "greater than the expected number of a tumor derived from cells of the trigeminal nerve occurring in a specific population in a given time period; trigeminal neuromas are rare tumors that may involve any part of the nerve complex, including peripheral divisions of the nerve" [https://doi.org/10.1097/00006123-199802000-00015]
synonym: "increased trigeminal nerve neuroma incidence" EXACT []
synonym: "trigeminal neuroma" RELATED []
is_a: MP:0001065 ! abnormal trigeminal nerve morphology
is_a: MP:0010281 ! increased nervous system tumor incidence

[Term]
id: MP:0013876
name: absent ductus venosus valve
def: "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
comment: This transient prenatal structure does not exist in humans.  It is present in many other species including mouse, rat, cattle and sheep.
synonym: "absent valve of ductus venosus" EXACT []
is_a: MP:0013877 ! abnormal ductus venosus valve morphology

[Term]
id: MP:0013877
name: abnormal ductus venosus valve morphology
def: "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
comment: This transient prenatal structure does not exist in humans.  It is present in many other species including mouse, rat, cattle and sheep.
synonym: "abnormal morphology of valve of ductus venosus" EXACT []
is_a: MP:0013873 ! abnormal ductus venosus morphology

[Term]
id: MP:0013878
name: abnormal ductus venosus valve topology
def: "abnormal position of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
comment: This transient prenatal structure does not exist in humans.  It is present in many other species including mouse, rat, cattle and sheep.
synonym: "abnormal topology of valve of ductus venosus" EXACT []
is_a: MP:0013877 ! abnormal ductus venosus valve morphology

[Term]
id: MP:0013879
name: duplication of ductus venosus
def: "duplication of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [https://orcid.org/0000-0003-3691-0324]
synonym: "double ductus venosus" EXACT []
is_a: MP:0013873 ! abnormal ductus venosus morphology

[Term]
id: MP:0013880
name: absent ductus venosus
def: "absence of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during development to adulthood" [https://orcid.org/0000-0003-3691-0324]
synonym: "absence of ductus venosus" EXACT []
is_a: MP:0013873 ! abnormal ductus venosus morphology

[Term]
id: MP:0013881
name: abnormal CD4-positive, CD25-positive NK T cell number
def: "anomaly in the number of CD4-positive NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0013518 ! abnormal CD4-positive NK T cell number

[Term]
id: MP:0013882
name: decreased CD4-positive, CD25-positive NK T cell number
def: "reduction in the number of CD4-positive NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
synonym: "reduced CD4-positive, CD25-positive NK T cell number" EXACT []
is_a: MP:0013519 ! decreased CD4-positive NK T cell number
is_a: MP:0013881 ! abnormal CD4-positive, CD25-positive NK T cell number

[Term]
id: MP:0013883
name: increased CD4-positive, CD25-positive NK T cell number
def: "increase in the number of CD4-positive NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0013520 ! increased CD4-positive NK T cell number
is_a: MP:0013881 ! abnormal CD4-positive, CD25-positive NK T cell number

[Term]
id: MP:0013884
name: abnormal CD4-negative, CD25-positive NK T cell number
def: "anomaly in the number of CD4-negative NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0013509 ! abnormal CD4-negative NK T cell number

[Term]
id: MP:0013885
name: decreased CD4-negative, CD25-positive NK T cell number
def: "reduction in the number of CD4-negative NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
synonym: "reduced CD4-negative, CD25-positive NK T cell number" EXACT []
is_a: MP:0013510 ! decreased CD4-negative NK T cell number
is_a: MP:0013884 ! abnormal CD4-negative, CD25-positive NK T cell number

[Term]
id: MP:0013886
name: increased CD4-negative, CD25-positive NK T cell number
def: "increase in the number of CD4-negative NK T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0013511 ! increased CD4-negative NK T cell number
is_a: MP:0013884 ! abnormal CD4-negative, CD25-positive NK T cell number

[Term]
id: MP:0013887
name: abnormal T cell compartment
def: "anomaly in the distribution of subsets or occurrence of new subsets within the T cell compartment" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0000717 ! abnormal lymphocyte cell number

[Term]
id: MP:0013888
name: abnormal CD8-positive, CD25-positive alpha-beta T cell number
def: "anomaly in the number of CD8-positive alpha-beta T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0008077 ! abnormal CD8-positive, alpha-beta T cell number

[Term]
id: MP:0013889
name: decreased CD8-positive, CD25-positive alpha-beta T cell number
def: "reduction in the number of CD8-positive alpha-beta T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
synonym: "reduced CD8-positive, CD25-positive alpha-beta T cell number" EXACT []
is_a: MP:0008079 ! decreased CD8-positive, alpha-beta T cell number
is_a: MP:0013888 ! abnormal CD8-positive, CD25-positive alpha-beta T cell number

[Term]
id: MP:0013890
name: increased CD8-positive, CD25-positive alpha-beta T cell number
def: "increase in the number of CD8-positive alpha-beta T cells expressing the activation marker CD25" [https://orcid.org/0000-0003-3662-4192]
is_a: MP:0008078 ! increased CD8-positive, alpha-beta T cell number
is_a: MP:0013888 ! abnormal CD8-positive, CD25-positive alpha-beta T cell number

[Term]
id: MP:0013891
name: increased common myeloid progenitor cell number
def: "increased number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [MGI:llw2]
synonym: "increased cfu-gemm number" EXACT []
synonym: "increased CFU-S" RELATED []
synonym: "increased CMP cell number" RELATED []
synonym: "increased CMPs" RELATED []
synonym: "increased multipotential myeloid stem cell number" RELATED []
synonym: "increased myeloid stem cell number" RELATED []
synonym: "increased pluripotent stem cell (bone marrow) number" RELATED []
is_a: MP:0006410 ! abnormal common myeloid progenitor cell morphology

[Term]
id: MP:0013892
name: increased common lymphocyte progenitor cell number
def: "increased number of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
synonym: "increased CLP number" EXACT []
synonym: "increased common lymphoid progenitor cell number" EXACT []
is_a: MP:0008249 ! abnormal common lymphocyte progenitor cell morphology

[Term]
id: MP:0013893
name: decreased common lymphocyte progenitor cell number
def: "reduced number of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
synonym: "decreased CLP number" EXACT []
synonym: "decreased common lymphoid progenitor cell number" EXACT []
synonym: "reduced CLP number" EXACT []
synonym: "reduced common lymphoid progenitor cell number" EXACT []
is_a: MP:0008249 ! abnormal common lymphocyte progenitor cell morphology

[Term]
id: MP:0013894
name: abnormal behavioral response to amphetamine
def: "anomaly in the behavioral response induced by amphetamine such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal behavioural response to amphetamine" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance

[Term]
id: MP:0013895
name: abnormal eyelid cilium morphology
def: "any structural anomaly of the hairs that grow at the edge of the upper or lower eyelid; eyelashes protect the eye from debris and are sensitive to touch, thus providing a warning that an object is near the eye (which is then closed reflexively)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eyelash morphology" EXACT []
synonym: "abnormal eyelid cilia morphology" EXACT []
synonym: "abnormal lash morphology" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology

[Term]
id: MP:0013896
name: abnormal eyelid cilium number
def: "anomaly in the number of the hairs that grow at the edge of the upper or lower eyelid" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eyelash number" EXACT []
synonym: "abnormal eyelid cilia number" EXACT []
synonym: "abnormal lash number" EXACT []
is_a: MP:0013895 ! abnormal eyelid cilium morphology

[Term]
id: MP:0013897
name: decreased eyelid cilium number
def: "reduction in the number of the hairs that grow at the edge of the upper or lower eyelid" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased eyelash number" EXACT []
synonym: "decreased eyelid cilia number" EXACT []
synonym: "decreased lash number" EXACT []
is_a: MP:0013896 ! abnormal eyelid cilium number

[Term]
id: MP:0013898
name: short eyelid cilia
def: "decreased length of any of the hairs that grow at the edge of the upper or lower eyelid" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased eyelash length" EXACT []
synonym: "decreased eyelid cilia length" EXACT []
synonym: "decreased eyelid cilium length" EXACT []
synonym: "decreased lash length" EXACT []
is_a: MP:0013895 ! abnormal eyelid cilium morphology

[Term]
id: MP:0013899
name: abnormal seminal vesicle epithelium morphology
def: "any structural anomaly of the pseudostratified columnar epithelium that lines the seminal vesicles and consists of tall, non-ciliated columnar cells and short, rounded basal cells that rest on the basal lamina; polarized columnar cells show features typical of secretory epithelium, including a well-developed Golgi complex, abundant rough endoplasmic reticulum, numerous mitochondria, and apical secretory vesicles; basal cells are the stem cells from which the columnar cells are derived" [https://orcid.org/0000-0002-6490-7723, ISBN:0781767903, ISBN:1455703079]
synonym: "abnormal gonecyst epithelium morphology" EXACT []
synonym: "abnormal seminal gland epithelium morphology" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0013900
name: seminal vesicle epithelium degeneration
def: "a retrogressive impairment of function or destruction of the pseudostratified columnar epithelium that lines the seminal vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "seminal gland epithelium degeneration" EXACT []
is_a: MP:0013899 ! abnormal seminal vesicle epithelium morphology

[Term]
id: MP:0013901
name: absent female preputial gland
def: "absence of the paired, lobulated, modified sebaceous glands located on the side of the clitoris in female rodents; in contrast to the preputial glands in male rodents, clitoral glands are a minor source of olfactory stimuli contributing to sexual attractivity; unlike other sebaceous glands, they undergo progressive atrophy of the glandular portion with marked ductal ectasia as rodents age; there is no true anatomical equivalent in humans" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent clitoral gland" EXACT []
synonym: "absent clitoral glands" EXACT []
synonym: "absent female preputial glands" EXACT []
is_a: MP:0011834 ! abnormal female preputial gland morphology

[Term]
id: MP:0013902
name: abnormal seminal vesicle physiology
def: "any functional anomaly of the sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles secrete a whitish yellow alkaline fluid that constitutes 60-70 percent of the ejaculate in humans; seminal vesicle fluid secretion is androgen-dependent, fructose-rich, and important for semen coagulation, sperm motility, and stability of sperm chromatin and suppression of the immune activity in the female reproductive tract" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal gonecyst physiology" EXACT []
synonym: "abnormal seminal gland physiology" EXACT []
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0013903
name: abnormal seminal vesicle fluid composition
def: "any alteration in the expected chemical makeup or appearance of the whitish yellow alkaline fluid secreted by the seminal vesicles that constitutes 60-70 percent of the ejaculate in humans; the secretory product of the columnar epithelial cell, which may be seen in the lumen of seminal vesicles, is strongly acidophilic; it contains large amounts of fructose (used by spermatozoa as an energy source for motility) in addition to water, K+ ions, phosphorylcholine, prostaglandins, flavins, citrate, ascorbic acid, and several amino acids and enzymes; seminal vesicle fluid is responsible for coagulation of the ejaculate, can alter sperm motility and capacitation, and acts as an immunosuppressant in the female reproductive tract" [http://www.lab.anhb.uwa.edu.au/mb140/corepages/malerepro/malerepro.htm#LabSeminal, https://en.wikipedia.org/wiki/Seminal_vesicle#Function, https://orcid.org/0000-0002-6490-7723, ISBN:0781767903, ISBN:1455703079]
is_a: MP:0013902 ! abnormal seminal vesicle physiology

[Term]
id: MP:0013904
name: abnormal seminal vesicle muscle layer morphology
def: "any structural anomaly of the thick muscular layer of the seminal vesicle consisting of an inner circular and outer longitudinal layer of smooth muscle which contracts during the emission phase of ejaculation to expel seminal vesicle fluid into the prostatic urethra" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal muscular coat of seminal gland morphology" EXACT []
synonym: "abnormal muscular layer of seminal gland morphology" EXACT []
synonym: "abnormal seminal vesicle muscular coat morphology" EXACT []
is_a: MP:0002059 ! abnormal seminal vesicle morphology

[Term]
id: MP:0013905
name: preputial gland inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in any of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa" [https://orcid.org/0000-0002-6490-7723]
synonym: "preputial inflammation" EXACT []
is_a: MP:0002254 ! reproductive system inflammation
is_a: MP:0005647 ! abnormal sex gland physiology

[Term]
id: MP:0013906
name: absent embryonic telencephalon
def: "absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent telencephalic vesicles" EXACT []
is_a: MP:0000934 ! abnormal telencephalon development

[Term]
id: MP:0013907
name: abnormal cerebrospinal fluid flow
def: "any anomaly in the dynamic process by which CSF circulates from the sites of secretion to the sites of absorption according to a unidirectional rostrocaudal flow in ventricular cavities and a multidirectional flow in subarachnoid spaces; CSF produced by the choroid plexuses in the lateral ventricles travels through interventricular foramina to the third ventricle, and then the fourth ventricle via the cerebral aqueduct and finally to the subarachnoid spaces via the median aperture (foramen of Magendie) of the fourth ventricle; in the cranial subarachnoid space, CSF circulates rostrally to the villous sites of absorption or caudally to the spinal subarachnoid space; CSF circulation through the ventricular system is driven by motile cilia on ependymal cells of the brain; CSF flow is pulsatile, corresponding to the systolic pulse wave in choroidal arteries; additional factors such as respiratory waves, the subject's posture, jugular venous pressure and physical effort also modulate CSF flow dynamics and pressure" [https://orcid.org/0000-0002-6490-7723, PMID:22100360, PMID:24229449]
synonym: "abnormal cerebrospinal fluid circulation" EXACT []
synonym: "abnormal CSF circulation" EXACT []
synonym: "abnormal CSF flow" EXACT []
is_a: MP:0021024 ! abnormal cerebrospinal fluid physiology

[Term]
id: MP:0013908
name: small lateral ventricles
def: "decreased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650]
synonym: "decreased lateral ventricle size" EXACT []
synonym: "decreased ventricle of cerebral hemisphere size" EXACT []
synonym: "decreased ventriculus lateralis size" EXACT []
synonym: "reduced lateral ventricle size" EXACT []
is_a: MP:0000823 ! abnormal lateral ventricle morphology
is_a: MP:0013227 ! small brain ventricles

[Term]
id: MP:0013909
name: small third ventricle
def: "decreased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840]
synonym: "decreased 3rd ventricle size" EXACT []
synonym: "decreased ventriculus tertius size" EXACT []
synonym: "reduced 3rd ventricle size" EXACT []
synonym: "reduced ventriculus tertius size" EXACT []
synonym: "small 3rd ventricle" EXACT []
synonym: "small ventriculus tertius" EXACT []
is_a: MP:0000826 ! abnormal third ventricle morphology
is_a: MP:0013227 ! small brain ventricles

[Term]
id: MP:0013910
name: small fourth ventricle
def: "decreased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [https://orcid.org/0000-0003-3691-0324, MESH:A08.186.211.276.500]
synonym: "decreased fourth ventricle size" EXACT []
synonym: "reduced fourth ventricle size" EXACT []
synonym: "small 4th ventricle" EXACT []
synonym: "small IVth ventricle" EXACT []
synonym: "small rhombencephalic ventricle" EXACT []
synonym: "small ventricle of rhombencephalon" EXACT []
synonym: "small ventriculus quartus" EXACT []
is_a: MP:0000828 ! abnormal fourth ventricle morphology
is_a: MP:0013227 ! small brain ventricles

[Term]
id: MP:0013911
name: fused vestibular saccule and utricle
def: "union of the saccule and utricle of the inner ear vestibule into one structure" [https://orcid.org/0000-0003-3691-0324]
synonym: "fusion of saccule and utricle" EXACT []
synonym: "utrico-saccular fusion" EXACT []
is_a: MP:0006089 ! abnormal vestibular saccule morphology

[Term]
id: MP:0013912
name: obsolete abnormal circardian rhythm entrainment
def: "anomaly in the synchronization of a circadian rhythm to environmental time cues such as light" [GO:0009649]
is_obsolete: true
replaced_by: MP:0020476

[Term]
id: MP:0013913
name: absent costovertebral joint
def: "one or more ribs are not connected to vertebra, where this connection is normally made" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent rib-vertebral column attachment" EXACT []
synonym: "rib not connected to vertebra" EXACT []
is_a: MP:0008149 ! abnormal costovertebral joint morphology

[Term]
id: MP:0013914
name: absent intracranial segment of vertebral artery
def: "absence of a segment of a vertebral artery when the absent segment would normally be located inside the skull" [https://orcid.org/0000-0003-4606-0597, url:https\://radiopaedia.org/articles/vertebral-artery]
synonym: "absent fourth segment of vertebral artery" EXACT []
synonym: "absent intracranial vertebral artery segment" EXACT []
synonym: "absent intradural vertebral artery segment" EXACT []
is_a: MP:0011513 ! abnormal vertebral artery morphology

[Term]
id: MP:0013915
name: abnormal brachial plexus formation
def: "abnormal formation of the arrangement of nerve fibers, running from the spine, formed by the ventral rami of the lower cervical and upper thoracic nerve root, specifically from below the fifth cervical vertebra to above the first thoracic vertebra" [UBERON:0001814]
synonym: "abnormal brachial nerve plexus formation" EXACT []
is_a: MP:0002752 ! abnormal somatic nervous system morphology

[Term]
id: MP:0013916
name: decreased intestine length
def: "reduced length of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions" [ISBN:0-683-40008-8]
synonym: "reduced length of intestine" EXACT []
synonym: "short intestine" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0013917
name: persistent right 6th pharyngeal arch artery
def: "failure of right 6th pharyngeal arch artery regression" [https://orcid.org/0000-0003-4606-0597]
synonym: "persistent right 6th PAA" EXACT []
synonym: "persistent right sixth branchial arch artery" EXACT []
is_a: MP:0006355 ! abnormal sixth pharyngeal arch artery morphology

[Term]
id: MP:0013918
name: abnormal endolymphatic sac topology
def: "abnormal position of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone" [PMID:1346922]
synonym: "abnormal Bottcher space topology" EXACT []
synonym: "abnormal Cotunnius space topology" EXACT []
synonym: "abnormal sacculus endolymphaticus topology" EXACT []
synonym: "abnormal saccus endolymphaticu topology" EXACT []
is_a: MP:0006011 ! abnormal endolymphatic duct morphology

[Term]
id: MP:0013919
name: abnormal response to electrical stimuli
def: "ny deviation from the expected reflex action normally induced by an electrical stimulus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0012079 ! abnormal spinal reflex

[Term]
id: MP:0013920
name: hyperresponsive to electrical stimuli
def: "lower threshold to exhibit an expected reflex action normally induced by an electrical stimulus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0013919 ! abnormal response to electrical stimuli

[Term]
id: MP:0013921
name: hyporesponsive to electrical stimuli
def: "higher threshold to exhibit an expected reflex action normally induced by an electrical stimulus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0013919 ! abnormal response to electrical stimuli

[Term]
id: MP:0013922
name: unresponsive to electrical stimuli
def: "inability to exhibit an expected reflex action normally induced by an electrical stimulus" [https://orcid.org/0000-0003-3691-0324]
subset: IMPC
is_a: MP:0013919 ! abnormal response to electrical stimuli

[Term]
id: MP:0013923
name: small prevertebral sympathetic ganglia
def: "decreased size of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia" [ISBN:0-683-40008-8]
synonym: "decreased prevertebral ganglion size" EXACT []
synonym: "reduced prevertebral ganglion size" EXACT []
is_a: MP:0008316 ! abnormal prevertebral ganglion morphology

[Term]
id: MP:0013924
name: abnormal dural venous sinus morphology
def: "any structural anomaly of the endothelium-lined venous channels in the dura mater" [ISBN:0-683-40008-8]
synonym: "abnormal cerebral sinus morphology" EXACT []
synonym: "abnormal cranial dural venous sinus morphology" EXACT []
synonym: "abnormal dural sinus morphology" EXACT []
synonym: "abnormal dural vein morphology" EXACT []
synonym: "abnormal sinus of dura mater morphology" EXACT []
synonym: "abnormal venous dural sinus morphology" EXACT []
is_a: MP:0004950 ! abnormal brain vasculature morphology

[Term]
id: MP:0013925
name: abnormal vascular plexus formation
def: "any anomaly in the development of a vascular network formed by frequent anastomoses between the blood vessels" [http://purl.obolibrary.org/obo/UBERON_0005629]
is_a: MP:0000259 ! abnormal vascular development

[Term]
id: MP:0013926
name: absent neurohypophysis
def: "absence of the posterior lobe of the pituitary gland" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0004164 ! abnormal neurohypophysis morphology

[Term]
id: MP:0013927
name: abnormal facial nerve topology
def: "abnormal position of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001071 ! abnormal facial nerve morphology

[Term]
id: MP:0013928
name: thin motoric part of trigeminal nerve
def: "slender appearance of the portion of the trigeminal nerve containing motor fibers, motor fibers are only found in the mandibular branch of the trigeminal nerve and derive from the basal plate of the embryonic pons" [http://teachmeanatomy.info/head/cranial-nerves/trigeminal-nerve/, https://en.wikipedia.org/wiki/Trigeminal_nerve]
is_a: MP:0001065 ! abnormal trigeminal nerve morphology

[Term]
id: MP:0013929
name: absent eye muscles
def: "absence of the muscles of the eye" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003686 ! abnormal eye muscle morphology

[Term]
id: MP:0013930
name: abnormal digastric muscle connection
def: "any anomaly in the attachment of the digastric muscles" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013815 ! abnormal digastric muscle morphology

[Term]
id: MP:0013931
name: abnormal olfactory bulb position
def: "anomaly in the location or orientation of the olfactory bulb" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000819 ! abnormal olfactory bulb morphology

[Term]
id: MP:0013932
name: fragmented Meckel's cartilage
def: "the Meckel's carilage is broken into separate pieces" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005587 ! abnormal Meckel's cartilage morphology

[Term]
id: MP:0013933
name: short Meckel's cartilage
def: "length reduction or truncation of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular cartilage length" EXACT []
synonym: "decreased Meckel cartilage length" EXACT []
synonym: "decreased Meckel's cartilage length" EXACT []
synonym: "reduced mandibular cartilage length" EXACT []
synonym: "reduced Meckel cartilage length" EXACT []
synonym: "reduced Meckel's cartilage length" EXACT []
synonym: "short mandibular cartilage" EXACT []
synonym: "short Meckel cartilage" EXACT []
synonym: "truncated mandibular cartilage" EXACT []
synonym: "truncated Meckel cartilage" EXACT []
synonym: "truncated Meckel's cartilage" EXACT []
is_a: MP:0030026 ! small Meckel's cartilage

[Term]
id: MP:0013934
name: supratentorial ventricles enlargement
def: "increase in size of the ventricles located above the tentorium cerebelli in the cerebrum" [https://en.wikipedia.org/wiki/Supratentorial_region]
synonym: "enlarged supratentorial ventricles" EXACT []
synonym: "increased supratentorial ventricles size" EXACT []
is_a: MP:0011380 ! enlarged brain ventricles

[Term]
id: MP:0013935
name: basal brain tissue herniation
def: "protrusion of the tissue from the base of the brain through rigid dural folds or the skull" [https://doi.org/10.1016/B978-0-12-804075-1.00001-8]
synonym: "herniated basal brain tissue" EXACT []
is_a: MP:0002152 ! abnormal brain morphology

[Term]
id: MP:0013936
name: abnormal thymus topology
def: "abnormal position of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0013937
name: absent lobe of thyroid gland
def: "absence of one or more of the conical shaped sections of the thyroid gland" [http://purl.obolibrary.org/obo/UBERON_0001118]
is_a: MP:0000681 ! abnormal thyroid gland morphology

[Term]
id: MP:0013938
name: abnormal esophagus topology
def: "abnormal position of the part of the digestive canal through which food passes from the pharynx to the stomach" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal oesophagus topology" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0013939
name: abnormal plasmablast morphology
def: "any structural anomaly of an activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative" [CL:0000980]
is_a: MP:0008171 ! abnormal mature B cell morphology

[Term]
id: MP:0013940
name: abnormal plasmablast number
def: "anomaly in the number of an activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative" [CL:0000980]
is_a: MP:0013939 ! abnormal plasmablast morphology

[Term]
id: MP:0013941
name: abnormal enthesis morphology
def: "any structural anomaly of the connective tissue between tendon and bone insertion sites; the area which acts to transmit tensile load from soft tissues to bone; they may be of the dense fibrous connective tissue or fibrocartilage type; fibrous entheses attach directly to bone or periosteum primarily via fibrous tissue, and fibrocartilaginous entheses attach to bone through a transitional layer of fibrocartilage from the fibrous tendon tissue" [PMID:25489552]
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0013942
name: enthesitis
def: "inflammation of the entheses, the sites where tendons or ligaments insert into the bone; the entheses are any point of attachment of skeletal muscles to the bone, where recurring stress or inflammatory autoimmune disease can cause inflammation or occasionally fibrosis and calcification" [https://en.wikipedia.org/wiki/Enthesitis]
synonym: "enthesopathy" EXACT []
synonym: "pathologic condition involving the entheses" BROAD []
is_a: MP:0001533 ! abnormal skeleton physiology
is_a: MP:0001846 ! increased inflammatory response

[Term]
id: MP:0013943
name: abnormal ureter topology
def: "abnormal position of the tube that conducts the urine from the renal pelvis to the bladder" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000534 ! abnormal ureter morphology

[Term]
id: MP:0013944
name: persistent cloacal membrane
def: "failure of the cloacal membrane proper to rupture and regress during development" [PMID:30294789]
synonym: "persisting cloacal membrane" EXACT []
is_a: MP:0011837 ! abnormal cloacal membrane morphology

[Term]
id: MP:0013945
name: abnormal elbow joint morphology
def: "any structural anomaly of the joint that connects the forelimb zeugopod and stylopod skeletons" [UBERON:0001490]
synonym: "abnormal articulatio cubiti morphology" EXACT []
synonym: "abnormal cubital region joint morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030807 ! abnormal forelimb joint morphology

[Term]
id: MP:0013946
name: abnormal perirectal tissue morphology
def: "any structural anomaly of the tissue(s) surrounding the rectum" [https://medical-dictionary.thefreedictionary.com/perirectal, https://www.merriam-webster.com/medical/perirectal]
is_a: MP:0000492 ! abnormal rectum morphology

[Term]
id: MP:0013947
name: abnormal paraaortic body morphology
def: "any structural anomaly of the chromaffin paraganglion located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery" [UBERON:0001237]
synonym: "abnormal organ of Zuckerkandl morphology" EXACT []
synonym: "abnormal para-aortic body morphology" EXACT []
synonym: "abnormal paraganglion of Zuckerkandl morphology" EXACT []
is_a: MP:0001034 ! abnormal parasympathetic ganglion morphology

[Term]
id: MP:0013948
name: intraembryonal intestine elongation
is_a: MP:0010158 ! abnormal intestine development

[Term]
id: MP:0013949
name: fusion of axis and occipital bones
def: "union of elements of the second cervical vertebra (axis, C2) and the bone at the lower, posterior part of the skull into one structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "axis and occipital bone fusion" EXACT []
synonym: "dens axis and occipital bone fused" EXACT []
is_a: MP:0004608 ! abnormal cervical axis morphology

[Term]
id: MP:0013950
name: abnormal dorsal root ganglion topology
def: "abnormal position of the dorsal root ganglion in relation to other structures" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal topology of dorsal root ganglion" EXACT []
is_a: MP:0000961 ! abnormal dorsal root ganglion morphology

[Term]
id: MP:0013951
name: abnormal descending aorta topology
def: "abnormal position of the descending aorta in relation to other structures" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal topology of descending aorta" EXACT []
is_a: MP:0009869 ! abnormal descending aorta morphology

[Term]
id: MP:0013952
name: retroesophageal left subclavian artery
def: "the left subclavian artery arises from the descending portion of the aortic arch, crossing over to the left upper extremity behind the esophagus" [PMID:23869265]
synonym: "retro-esophageal left subclavian artery" EXACT []
synonym: "retro-oesophageal left subclavian artery" EXACT []
is_a: MP:0010488 ! abnormal left subclavian artery morphology

[Term]
id: MP:0013953
name: left sided brachiocephalic trunk
def: "the brachiocephalic trunk arises on the left side of the body, often seen in conjunction with right aortic arch" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010663 ! abnormal brachiocephalic trunk morphology

[Term]
id: MP:0013954
name: increased intestine length
def: "increased length of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions" [ISBN:0683400088]
synonym: "long intestine" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0013955
name: increased colon length
def: "increased length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
synonym: "long colon" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0013959 ! increased large intestine length

[Term]
id: MP:0013956
name: decreased colon length
def: "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
synonym: "reduced colon length" EXACT []
synonym: "short colon" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
is_a: MP:0013960 ! decreased large intestine length

[Term]
id: MP:0013957
name: increased small intestine length
def: "increased length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
synonym: "long small intestine" EXACT []
is_a: MP:0013954 ! increased intestine length
is_a: MP:0020999 ! abnormal small intestine length

[Term]
id: MP:0013958
name: decreased small intestine length
def: "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
synonym: "reduced small intestine length" EXACT []
synonym: "short small intestine" EXACT []
is_a: MP:0013916 ! decreased intestine length
is_a: MP:0020999 ! abnormal small intestine length

[Term]
id: MP:0013959
name: increased large intestine length
def: "increased length of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal" [ISBN:0683400088]
synonym: "long large intestine" EXACT []
is_a: MP:0000489 ! abnormal large intestine morphology
is_a: MP:0013954 ! increased intestine length

[Term]
id: MP:0013960
name: decreased large intestine length
def: "reduced length of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal" [ISBN:0683400088]
synonym: "reduced large intestine length" EXACT []
synonym: "short large intestine" EXACT []
is_a: MP:0000489 ! abnormal large intestine morphology
is_a: MP:0013916 ! decreased intestine length

[Term]
id: MP:0013961
name: abnormal Hensen stripe morphology
def: "any structural anomaly of the dark, nonstriated, V-shaped band (ridge) found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells; Hensen's stripe is continuous with a more external homogeneous basal layer, from which a marginal band of an amorphous substance originates; the marginal net extends from the marginal band and attaches the lateral border of the TM to Hensen's cells of the organ of Corti. Hensen's stripe and the homogeneous basal layers display interruptions through which the fibrillar structure of the TM is visible" [ISBN:3662026767, PMID:25080593]
synonym: "abnormal Hensen's stripe morphology" EXACT []
is_a: MP:0003169 ! abnormal scala media morphology

[Term]
id: MP:0013962
name: absent Hensen stripe
def: "absence of the dark, nonstriated, V-shaped band (ridge) that is normally found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells" [ISBN:3662026767, PMID:25080593]
synonym: "absent Hensen's stripe" EXACT []
is_a: MP:0013961 ! abnormal Hensen stripe morphology

[Term]
id: MP:0013963
name: jugular vein stenosis
def: "abnormal narrowing or constriction of any of the veins that bring deoxygenated blood from the head back to the heart via the superior vena cava" [https://orcid.org/0000-0002-6490-7723, UBERON:0004711]
synonym: "jugular vein narrowing" EXACT []
is_a: MP:0013872 ! abnormal jugular vein morphology
is_a: MP:0031477 ! vein stenosis

[Term]
id: MP:0013964
name: absent tongue muscles
def: "absence of any or all of the extrinsinc or intrinsic muscles of the tongue" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lingual muscles" EXACT []
is_a: MP:0004136 ! abnormal tongue muscle morphology

[Term]
id: MP:0013965
name: abnormally deep median sulcus of tongue
def: "increased depth of the median groove that extends from the tip of the tongue to the foramen cecum and divides the dorsum of the tongue into right and left halves" [https://medical-dictionary.thefreedictionary.com/median+sulcus+of+tongue, https://orcid.org/0000-0002-6490-7723, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Median-sulcus-of-tongue]
synonym: "abnormally deep median groove of tongue" EXACT []
synonym: "abnormally deep median longitudinal raphe of tongue" EXACT []
is_a: MP:0031451 ! abnormal median sulcus of tongue morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0013966
name: abnormal infrahyoid muscle morphology
def: "any structural anomaly of any of the four paired muscles located in the anterior neck below the hyoid bone, within the muscular triangle; these muscles are long and flat in shape, similar to a belt or strap, and are responsible for depressing the hyoid during swallowing; they either originate from or insert on to the hyoid bone and include the sternohyoid, sternothyroid, thyrohyoid and omohyoid muscles" [https://en.wikipedia.org/wiki/Infrahyoid_muscles, https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/infrahyoid-muscles]
synonym: "abnormal strap muscle morphology" BROAD []
synonym: "infrahyoid muscle dysplasia" NARROW []
is_a: MP:0002253 ! abnormal pharyngeal muscle morphology

[Term]
id: MP:0013967
name: abnormal infrahyoid muscle connection
def: "any anomaly in the attachment of the infrahyoid muscle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013966 ! abnormal infrahyoid muscle morphology

[Term]
id: MP:0013968
name: multiple persisting craniopharyngeal ducts
def: "presence of multiple openings in midline sphenoid body from the sellar floor to the nasopharynx" [PMID:24184521]
synonym: "multiple persistent craniopharyngeal canals" EXACT []
is_a: MP:0003817 ! abnormal pituitary diverticulum morphology

[Term]
id: MP:0013969
name: reduced sympathetic cervical ganglion size
def: "decreased size of one or more of the 3 paravertebral sympathetic ganglia, the superior, middle, and inferior cervical ganglia that provide sympathetic innervation to the smooth muscle, glands, and mucosa of the head" [http://purl.obolibrary.org/obo/UBERON_0001991, https://www.sciencedirect.com/topics/medicine-and-dentistry/cervical-ganglion]
synonym: "decreased sympathetic carvical ganglion size" EXACT []
synonym: "diminished sympathetic cervical ganglion material" EXACT []
synonym: "small sympathetic cervical ganglion" EXACT []
is_a: MP:0008317 ! abnormal paravertebral ganglion morphology

[Term]
id: MP:0013970
name: absent connection between subcutaneous lymph vessels and lymph sac
def: "absence of the attachment or communication between the subcutaneous lymph vessels and lymph sacs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001879 ! abnormal lymphatic vessel morphology

[Term]
id: MP:0013971
name: blood in lymph vessels
def: "abnormal presence of constituents of blood not normally found in lymph vessels" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010368 ! abnormal lymphatic system physiology

[Term]
id: MP:0013972
name: occipital vertebra
def: "rare anatomical variants resulting from incomplete or aberrant fusion of occipital bone ossification centers; most common occipital vertebrae variations include third condyle (condylus tertius), basilar process, paracondylar process and prebasioccipital arch" [https://radiopaedia.org/articles/occipital-vertebra?lang=us]
is_a: MP:0000137 ! abnormal vertebrae morphology

[Term]
id: MP:0013973
name: abnormal hepatic vein connection
def: "any anomaly in the attachment of the hepatic vein to other vessels" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010439 ! abnormal hepatic vein morphology

[Term]
id: MP:0013974
name: abnormal coronary vein connection
def: "any anomaly in the attachment of the coronary vein to other vessels" [] {comment="https://orcid.org/0000-0003-4606-0597"}
is_a: MP:0010453 ! abnormal coronary vein morphology

[Term]
id: MP:0013975
name: abnormal coronary sinus connection
def: "any anomaly in the attachment of the coronary sinus to the cardiac veins or heart" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sinus coronarius connection" EXACT []
is_a: MP:0010436 ! abnormal coronary sinus morphology

[Term]
id: MP:0013976
name: abnormal left vena cava superior connection
def: "any anomaly in the connection formed by the left common cardinal vein and the left superior cardinal vein; this connection usually regresses during development" [PMID:33057803]
is_a: MP:0006064 ! abnormal superior vena cava morphology

[Term]
id: MP:0013977
name: symmetric azygos veins
def: "presence of a pair of similar caliber azygos veins on the left and right sides" [PMID:1805438]
is_a: MP:0011569 ! abnormal azygos vein morphology

[Term]
id: MP:0013978
name: abnormal carotid artery origin
def: "any anomaly in the location from which the carotid artery arises" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004181 ! abnormal carotid artery morphology

[Term]
id: MP:0013979
name: abnormal subclavian artery origin
def: "any anomaly in the location from which the subclavian artery arises" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003395 ! abnormal subclavian artery morphology

[Term]
id: MP:0013980
name: abnormal pulmonary artery origin
def: "any anomaly in the location from which the pulmonary artery arises" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000484 ! abnormal pulmonary artery morphology

[Term]
id: MP:0013981
name: double lumen aortic arch
def: "interuption of the 4th aortic arch and persistence of the 5th arch resulting in the presence of two lumens" [https://doi.org/10.1016/j.athoracsur.2015.10.014]
is_a: MP:0004113 ! abnormal aortic arch morphology

[Term]
id: MP:0013982
name: inverse situs of great intrathoracic arteries
def: "anomaly in the asymmetry of the large arteries of the thoracic region (aorta, pulmonary arteries, common carotid arteries, subclavian arteries) such that these structures on both the left and right side have the morphology normally seen on the opposite side of the body" [https://orcid.org/0000-0003-4606-0597, PMID:28776665]
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0013983
name: abnormal superior mesenteric vein morphology
def: "any structural anomaly of the blood vessel that drains blood from the small intestine, it combines with the splenic vein to form the hepatic portal vein" [UBERON:0001138]
is_a: MP:0002725 ! abnormal vein morphology

[Term]
id: MP:0013984
name: abnormal superior mesenterial vein connection
is_a: MP:0020492 ! abnormal superior mesenteric vein topology

[Term]
id: MP:0013985
name: abnormal umbilical vein topology
def: "abnormal position of the umbilical vein in relationship to other umbilical cord structures" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010667 ! abnormal umbilical vein morphology

[Term]
id: MP:0013986
name: abnormal vitelline vein topology
def: "abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0010666 ! abnormal vitelline vein morphology

[Term]
id: MP:0013987
name: absent intrahepatic inferior vena cava segment
def: "absence of the portion of the of inferior vena cava that connects to the hepatic veins" [http://pubs.rsna.org/doi/full/10.1148/rg.352140136, https://radiopaedia.org/articles/inferior-vena-cava-1]
is_a: MP:0006063 ! abnormal inferior vena cava morphology

[Term]
id: MP:0013988
name: absent portal vein segment
def: "absence of part but not all of the portal vein" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010668 ! abnormal hepatic portal vein morphology

[Term]
id: MP:0013989
name: symmetric hepatic veins
synonym: "symmetric liver veins" EXACT []
is_a: MP:0010439 ! abnormal hepatic vein morphology

[Term]
id: MP:0013990
name: abnormal common iliac artery morphology
def: "any structural anomaly of the two large arteries that originate from the aortic bifurcation of the abdomainal aorta; the right and left common iliac arteries run along each side of the body towards the edges of the pelvis, where they each split again into internal and external iliac arteries at the pelvic inlet" [http://www.healthline.com/human-body-maps/common-iliac-artery]
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0013991
name: abnormal common iliac artery origin
def: "any anomaly in the location from which the common iliac arteries arise; normally, these two large arteries originate from the aortic bifurcation of the abdomainal aorta" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013990 ! abnormal common iliac artery morphology

[Term]
id: MP:0013992
name: persistent dorsal ophthalmic artery
def: "the artery originates from the cavernous segment of the internal carotid artery and enters the orbit via the superior orbital fissure" [https://radiopaedia.org/articles/persistent-dorsal-ophthalmic-artery?lang=us, PMID:23430064]
is_a: MP:0003410 ! abnormal artery development
is_a: MP:0020489 ! abnormal ophthalmic artery morphology

[Term]
id: MP:0013993
name: anastomosis between basilar artery and common carotid artery
def: "any anomalous cross-connection between the basilar artery and the common carotid artery" [http://medical-dictionary.thefreedictionary.com/anastomosis]
is_a: MP:0012729 ! abnormal common carotid artery morphology
is_a: MP:0013186 ! abnormal basilar artery morphology

[Term]
id: MP:0013994
name: abnormal parasellar internal carotid artery branch morphology
def: "any structural anomaly of the branches of the segment of the internal carotid artery located in region in the brain next to the hollow in the skull bone that contains the pituitary gland running from the superomedial petrous apex to the proximal dural ring" [https://neurosurgerypaedia.org/wiki/doku.php?id=internal_carotid_artery_segments, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012730 ! abnormal internal carotid artery morphology

[Term]
id: MP:0013995
name: abnormal external carotid artery origin
def: "any anomaly in the location from which the external carotid artery arises" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012731 ! abnormal external carotid artery morphology

[Term]
id: MP:0013996
name: abnormal vertebral artery origin
def: "any anomaly in the location from which the vertebral artery arises; each vertebral artery usually arises from the supraposterior aspect of the first part of the subclavian artery" [https://doi.org/10.1093/qjmed/hcg003, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011513 ! abnormal vertebral artery morphology

[Term]
id: MP:0013997
name: abnormal internal carotid artery topology
def: "abnormal position of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012730 ! abnormal internal carotid artery morphology

[Term]
id: MP:0013998
name: absent canalicular internal carotid artery segment
def: "absence of the segment of the internal carotid artery that passes through the carotid canal" [https://orcid.org/0000-0003-4606-0597, https://radiopaedia.org/articles/internal-carotid-artery-1]
is_a: MP:0012730 ! abnormal internal carotid artery morphology

[Term]
id: MP:0013999
name: absent parasellar internal carotid artery
def: "absence of the segment of the internal carotid artery located in region in the brain next to the hollow in the skull bone that contains the pituitary gland running from the superomedial petrous apex to the proximal dural ring" [https://neurosurgerypaedia.org/wiki/doku.php?id=internal_carotid_artery_segments, https://orcid.org/0000-0003-4606-0597]
synonym: "absent internal carotid artery cavernous segment" EXACT []
is_a: MP:0012730 ! abnormal internal carotid artery morphology

[Term]
id: MP:0014000
name: anastomosis between internal carotid artery and basilar artery
def: "any anomalous cross-connection between the basilar artery and the internal carotid artery" [http://medical-dictionary.thefreedictionary.com/anastomosis]
is_a: MP:0012730 ! abnormal internal carotid artery morphology
is_a: MP:0013186 ! abnormal basilar artery morphology

[Term]
id: MP:0014001
name: abnormal vertebral artery topology
def: "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0011513 ! abnormal vertebral artery morphology

[Term]
id: MP:0014002
name: absent extracranial vertebral artery segment
def: "absence of a segment of a vertebral artery when the absent segment would normally be located outside the skull" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent extracranial segment of vertebral artery" EXACT []
is_a: MP:0011513 ! abnormal vertebral artery morphology

[Term]
id: MP:0014003
name: additional anastomosis between intracranial vertebral arteries
def: "greater than the expected number of connections between the segments of the vertebral arteries located within the skull" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011513 ! abnormal vertebral artery morphology

[Term]
id: MP:0014004
name: absent basilar artery segment
def: "absence of a portion of the basilar artery" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013186 ! abnormal basilar artery morphology

[Term]
id: MP:0014005
name: abnormal posterior communicating artery morphology
def: "any structural anomaly of one or both of the pair of right-sided and left-sided blood vessels in the circle of Willis that connect the three cerebral arteries of the same side" [UBERON:0001628]
synonym: "abnormal caudal communicating segment morphology" EXACT []
synonym: "abnormal posterior communicating segment of the basilar artery morphology" EXACT []
is_a: MP:0004950 ! abnormal brain vasculature morphology

[Term]
id: MP:0014006
name: absent posterior communicating artery
def: "missing the pair of right-sided and left-sided blood vessels in the circle of Willis that connect the three cerebral arteries of the same side" [UBERON:0001628]
synonym: "absent caudal communicating segment" EXACT []
synonym: "absent communicans posterior artery" EXACT []
synonym: "absent posterior communicating segment of the basilar artery" EXACT []
is_a: MP:0014005 ! abnormal posterior communicating artery morphology

[Term]
id: MP:0014007
name: abnormal labyrinthine artery morphology
def: "any structural anomaly of the long slender branch of the anterior inferior cerebellar artery (85%-100% cases) or basilar artery (<15% cases) that arises from near the middle of the artery; it accompanies the vestibulocochlear nerve through the internal acoustic meatus, and is distributed to the internal ear" [UBERON:0018231]
synonym: "abnormal arteria auditiva interna morphology" EXACT []
synonym: "abnormal arteria labyrinthi morphology" EXACT []
synonym: "anormal internal auditory artery morphology" EXACT []
is_a: MP:0004950 ! abnormal brain vasculature morphology

[Term]
id: MP:0014008
name: absent labyrinthine artery
def: "missing the long slender branch of the anterior inferior cerebellar artery (85%-100% cases) or basilar artery (<15% cases) that arises from near the middle of the artery" [UBERON:0018231]
synonym: "absent arteria auditiva interna" EXACT []
synonym: "absent arteria labyrinthi" EXACT []
synonym: "absent internal auditory artery" EXACT []
is_a: MP:0014007 ! abnormal labyrinthine artery morphology

[Term]
id: MP:0014009
name: anastomosis between middle cerebral arteries
def: "any anomalous cross-connection between the middle cerebral arteries" [http://medical-dictionary.thefreedictionary.com/anastomosis]
is_a: MP:0020487 ! abnormal middle cerebral artery morphology

[Term]
id: MP:0014010
name: abnormal peroxisome morphology
def: "any structural anomaly of a small cytoplasmic organelle enclosed by a single membrane that contains peroxidases and other enzymes which are important for a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism" [GO:0005777]
synonym: "abnormal peroxisomal morphology" EXACT []
synonym: "abnormal peroxisome vesicle morphology" EXACT []
is_a: MP:0014239 ! abnormal intracellular organelle morphology

[Term]
id: MP:0014011
name: abnormal ovary tissue architecture
def: "any anomaly in the texture of the ovarian tissue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001126 ! abnormal ovary morphology

[Term]
id: MP:0014012
name: abnormal cranial blood vasculature morphology
def: "any structural anomaly of blood vasculature that is part of a head" [UBERON:0011362]
synonym: "abnormal cranial blood vessel morphology" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology

[Term]
id: MP:0014013
name: abnormal cerebellar artery morphology
def: "any structural artery of an artery that supplies blood to the cerebellum" [UBERON:0003472]
is_a: MP:0002191 ! abnormal artery morphology
is_a: MP:0004950 ! abnormal brain vasculature morphology

[Term]
id: MP:0014014
name: abnormal anterior inferior cerebellar artery morphology
def: "any structural anomaly of a basilar artery branch that supplies the anterior portion of the inferior surface of the cerebellum" [UBERON:0009689]
is_a: MP:0011655 ! abnormal systemic artery morphology
is_a: MP:0014013 ! abnormal cerebellar artery morphology

[Term]
id: MP:0014015
name: abnormal superior cerebellar artery morphology
def: "any structural anomaly of the artery that arises near the termination of the basilar artery and passes lateralward immediately below the oculomotor nerve arriving at the upper surface of the cerebellum where it divides into branches which ramify in the pia mater and anastomose with those of the inferior cerebellar arteries" [UBERON:0001635]
is_a: MP:0014013 ! abnormal cerebellar artery morphology

[Term]
id: MP:0014016
name: abnormal circle of Willis morphology
def: "any structural anomaly of the circle of arteries that supply blood to the brain" [UBERON:0003709]
synonym: "abnormal arterial circle of Willis morphology" EXACT []
synonym: "abnormal cerebral arterial circle morphology" EXACT []
is_a: MP:0011655 ! abnormal systemic artery morphology

[Term]
id: MP:0014017
name: abnormal Wolffian duct connection
def: "aberrant attachment or incomplete connection of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) to the cloaca" [ISBN:0-683-40008-8]
is_a: MP:0003827 ! abnormal Wolffian duct morphology

[Term]
id: MP:0014018
name: embryo tumor
def: "presence of an unspecified tumor or aberrant growth in a prenatal organism" [https://orcid.org/0000-0003-3691-0324]
synonym: "embryo tumour" EXACT []
is_a: MP:0002019 ! abnormal tumor incidence

[Term]
id: MP:0014019
name: embryo cyst
def: "presence of one or more abnormal membranous sacs in any portion of embryonic tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic embryonic tissue" EXACT []
synonym: "embryo cysts" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0014020
name: intramural bleeding in blood vessel wall
def: "leakage of blood through the innermost layer of the blood vessel and flowing between the inner and outer vessel walls" [https://www.cedars-sinai.org/health-library/diseases-and-conditions/a/aortic-intramural-hematoma.html, https://www.sciencedirect.com/science/article/pii/S0735109716369054]
is_a: MP:0000249 ! abnormal blood vessel physiology

[Term]
id: MP:0014021
name: heterochrony
def: "a developmental change in the timing or rate of events resulting in changes in size or shape to a tissue or anatomical part" [http://www.dictionary.com/browse/heterochrony, https://en.wikipedia.org/wiki/Heterochrony]
synonym: "heterochrony of organs" EXACT []
is_a: MP:0005378 ! growth/size/body region phenotype

[Term]
id: MP:0014022
name: abnormal duodenum topology
def: "abnormal position of the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000497 ! abnormal small intestine placement
is_a: MP:0003271 ! abnormal duodenum morphology

[Term]
id: MP:0014023
name: abnormal intestine placement
def: "different location or arrangement of the digestive tube passing from the stomach to the anus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intestinal location" EXACT []
synonym: "abnormal intestinal placement" EXACT []
synonym: "abnormal intestinal position" EXACT []
synonym: "abnormal intestine location" EXACT []
synonym: "abnormal intestine position" EXACT []
is_a: MP:0000477 ! abnormal intestine morphology
is_a: MP:0003283 ! abnormal digestive organ placement

[Term]
id: MP:0014024
name: increased subchondral bone mineral content
def: "increased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces" [https://orcid.org/0000-0003-3691-0324, PMID:20392241]
synonym: "increased subchondral BMC" EXACT []
is_a: MP:0010123 ! increased bone mineral content

[Term]
id: MP:0014025
name: decreased subchondral bone mineral content
def: "decreased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces" [https://orcid.org/0000-0003-3691-0324, PMID:20392241]
synonym: "decreased subchondral BMC" EXACT []
synonym: "reduced subchondral bone mineral content" EXACT []
is_a: MP:0010124 ! decreased bone mineral content

[Term]
id: MP:0014026
name: abnormal respiratory epithelial transmembrane transport
def: "any anomaly in the directed movement of a substance from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014200 ! abnormal respiratory epithelium physiology

[Term]
id: MP:0014027
name: abnormal respiratory epithelial chloride transmembrane transport
def: "any anomaly in the directed movement of a chloride from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014026 ! abnormal respiratory epithelial transmembrane transport

[Term]
id: MP:0014028
name: decreased respiratory epithelial chloride transmembrane transport
def: "decrease in the directed movement of a chloride from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced respiratory epithelial chloride transmembrane transport" EXACT []
is_a: MP:0014027 ! abnormal respiratory epithelial chloride transmembrane transport

[Term]
id: MP:0014029
name: increased respiratory epithelial chloride transmembrane transport
def: "increase in the directed movement of a chloride from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014027 ! abnormal respiratory epithelial chloride transmembrane transport

[Term]
id: MP:0014030
name: abnormal mucous gland physiology
def: "any functional anomaly of any exocrine gland in which the principal secretory cells are mucus-secreting cells; mucus is a slippery secretion with lubricating or protective function produced by, and covering, mucous membranes; mucous fluid is typically produced from cells found in mucous glands, but may also originate from mixed glands, which contain both serous and mucous cells; mucous cells secrete products that are rich in glycoproteins and water; mucus is a viscous colloid containing antiseptic enzymes (such as lysozyme), immunoglobulins, inorganic salts, proteins such as lactoferrin, and glycoproteins known as mucins that are produced by goblet cells in the mucous membranes and submucosal glands" [http://en.wikipedia.org/wiki/Mucous_gland, https://orcid.org/0000-0003-3691-0324, UBERON:0000414]
synonym: "abnormal glandula mucosa physiology" EXACT []
synonym: "abnormal muciparous gland physiology" EXACT []
synonym: "abnormal mucousal gland physiology" EXACT []
synonym: "abnormal mucus-secreting gland physiology" EXACT []
is_a: MP:0013559 ! abnormal exocrine gland physiology

[Term]
id: MP:0014031
name: abnormal submucosal gland physiology
def: "any functional anomaly of the mucous-secreting glands located in the dense irregular connective tissue that lines organs and supports the mucosal membrane" [https://orcid.org/0000-0003-3691-0324, ISBN:0683400088]
is_a: MP:0014030 ! abnormal mucous gland physiology

[Term]
id: MP:0014032
name: abnormal mucous gland morphology
def: "any structural anomaly of any exocrine gland in which the principal secretory cells are mucus-secreting cells; mucus is a slippery secretion with lubricating or protective function produced by, and covering, mucous membranes; mucous glands typically stain lighter than serous glands during standard histological preparation; most are multicellular, but goblet cells are single-celled glands" [http://en.wikipedia.org/wiki/Mucous_gland, https://orcid.org/0000-0003-3691-0324, UBERON:0000414]
synonym: "abnormal glandula mucosa morphology" EXACT []
synonym: "abnormal muciparous gland morphology" EXACT []
synonym: "abnormal mucousal gland morphology" EXACT []
synonym: "abnormal mucus-secreting gland mophology" EXACT []
is_a: MP:0013558 ! abnormal exocrine gland morphology

[Term]
id: MP:0014033
name: abnormal submucosal gland morphology
def: "any structural anomaly of the mucous-secreting glands located in the dense irregular connective tissue that lines organs and supports the mucosal membrane" [https://orcid.org/0000-0003-3691-0324, ISBN:0683400088]
is_a: MP:0014032 ! abnormal mucous gland morphology

[Term]
id: MP:0014034
name: abnormal submucosal gland secretion
def: "any anomaly in the secretion of mucous and other substances from a submucosal gland" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0014031 ! abnormal submucosal gland physiology

[Term]
id: MP:0014035
name: decreased submucosal gland secretion
def: "a reduction in the rate or amount of secretion of mucous and other substances from a submucosal gland" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0014034 ! abnormal submucosal gland secretion

[Term]
id: MP:0014036
name: meconium ileus
def: "obstruction of the intestine due to abnormally thick meconium in the fetus and neonate" [ISBN:0683400088]
is_a: MP:0003270 ! intestinal obstruction

[Term]
id: MP:0014037
name: stranguria
def: "difficulty in micturition in which the urine is passed intermittently or drop by drop, and is associated with pain and tenesmus" [https://orcid.org/0000-0001-5208-3432, ISBN:0683400088]
synonym: "strangury" EXACT []
is_a: MP:0001756 ! abnormal urination

[Term]
id: MP:0014038
name: increased hepatocyte number
def: "greater than normal number of parenchymal liver cells" [https://orcid.org/0009-0005-7755-8314]
is_a: MP:0000607 ! abnormal hepatocyte morphology

[Term]
id: MP:0014039
name: abnormal sheltering behavior
def: "deviation from the usual behavior of visiting a shelter or nest used for resting/sleeping" [MPD:Molly, PMID:25264768]
synonym: "abnormal sheltering behaviour" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0014040
name: increased cellular sensitivity to DNA damaging agents
def: "greater incidence of cell death following exposure to agents that cause DNA damage" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008943 ! increased sensitivity to induced cell death

[Term]
id: MP:0014041
name: increased cellular sensitivity to cisplatin
def: "greater incidence of cell death following exposure to cisplatin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014040 ! increased cellular sensitivity to DNA damaging agents

[Term]
id: MP:0014042
name: decreased cellular sensitivity to DNA damaging agents
def: "reduced incidence of cell death following exposure to agents that cause DNA damage" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0008944 ! decreased sensitivity to induced cell death

[Term]
id: MP:0014043
name: decreased cellular sensitivity to cisplatin
def: "reduced incidence of cell death following exposure to cisplatin" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014042 ! decreased cellular sensitivity to DNA damaging agents

[Term]
id: MP:0014044
name: absent cardiac outflow tract
def: "absence of or complete failure to form the common arterial trunk that normally forms the aorta and pulmonary artery and the ventricular outflow regions" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent fetal outflow tract" EXACT []
synonym: "absent foetal outflow tract" EXACT []
synonym: "absent heart outflow tract" EXACT []
is_a: MP:0006126 ! abnormal cardiac outflow tract development

[Term]
id: MP:0014045
name: Mallory bodies
def: "stereotypical manifestations of hepatocyte injury that present as cytoplasmic inclusion bodies consisting of intermediate filament components (e.g., modified cytokeratins, chaperones and protein degradation machinery)" [PMID:17531973, PMID:7927209]
synonym: "Mallory body" EXACT []
synonym: "Mallory's hyaline" EXACT []
synonym: "Mallory-Denk bodies" EXACT []
synonym: "Mallory-Denk body" EXACT []
is_a: MP:0000607 ! abnormal hepatocyte morphology

[Term]
id: MP:0014046
name: abnormal mitophagy
def: "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [https://orcid.org/0000-0002-6490-7723, PMID:22743996]
synonym: "abnormal mitochondrial autophagy" EXACT []
synonym: "abnormal mitochondrion autophagy" EXACT []
is_a: MP:0008260 ! abnormal autophagy

[Term]
id: MP:0014047
name: abnormal gut-associated lymphoid tissue physiology
def: "any functional anomaly of the regional immune system located in the gut" [ISBN:0-8153-1691-7]
synonym: "abnormal GALT physiology" EXACT []
is_a: MP:0003762 ! abnormal immune organ physiology

[Term]
id: MP:0014048
name: abnormal Peyer's patch physiology
def: "any functional anomaly of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles" [MESH:A10.549.600, PMID:15841100]
is_a: MP:0014047 ! abnormal gut-associated lymphoid tissue physiology

[Term]
id: MP:0014049
name: increased T cell acute lymphoblastic leukemia incidence
def: "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many T-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood" [NCIT:C3183]
synonym: "increased acute T-cell lymphocytic leukaemia incidence" EXACT []
synonym: "increased acute T-cell lymphocytic leukemia incidence" EXACT []
synonym: "increased T acute lymphoblastic leukaemia incidence" EXACT []
synonym: "increased T acute lymphoblastic leukemia incidence" EXACT []
synonym: "increased T cell acute lymphoblastic leukaemia incidence" EXACT []
synonym: "increased T-ALL incidence" EXACT []
is_a: MP:0010336 ! increased acute lymphoblastic leukemia incidence

[Term]
id: MP:0014050
name: increased B cell acute lymphoblastic leukemia incidence
def: "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood; it is the most common type of acute lymphoblastic leukemia (ALL)" [NCIT:C8644]
synonym: "increased acute B-cell lymphocytic leukaemia incidence" EXACT []
synonym: "increased acute B-cell lymphocytic leukemia incidence" EXACT []
synonym: "increased B acute lymphoblastic leukaemia incidence" EXACT []
synonym: "increased B acute lymphoblastic leukemia incidence" EXACT []
synonym: "increased B cell acute lymphoblastic leukaemia incidence" EXACT []
synonym: "increased B-ALL incidence" EXACT []
is_a: MP:0010336 ! increased acute lymphoblastic leukemia incidence

[Term]
id: MP:0014051
name: abnormal maxillary-premaxillary suture morphology
def: "any structural anomaly of the line of union of the two portions of the maxilla (pre- and postmaxilla)" [ISBN:0683400088]
synonym: "abnormal incisive suture morphology" EXACT []
synonym: "abnormal premaxillary suture morphology" EXACT []
is_a: MP:0030230 ! abnormal facial suture morphology

[Term]
id: MP:0014052
name: increased male germ cell apoptosis
def: "increase in the number of male germ cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated male germ cell apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0008280 ! abnormal male germ cell apoptosis

[Term]
id: MP:0014053
name: dry hair
def: "hair characterized by the lack of natural or normal moisture" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002074 ! abnormal hair texture

[Term]
id: MP:0014054
name: abnormal sebocyte physiology
def: "any functional anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection" [https://orcid.org/0000-0002-6490-7723, PMID:19944183]
synonym: "abnormal acinar cell of sebaceous gland physiology" EXACT []
synonym: "abnormal sebaceous epithelial cell physiology" EXACT []
is_a: MP:0005501 ! abnormal skin physiology

[Term]
id: MP:0014055
name: abnormal sebocyte proliferation
def: "any anomaly in the expansion rate of sebocytes by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal sebaceous epithelial cell proliferation" EXACT []
synonym: "abnormal sebaceous gland acinar cell proliferation" EXACT []
is_a: MP:0014054 ! abnormal sebocyte physiology

[Term]
id: MP:0014056
name: increased sebocyte proliferation
def: "increase in the expansion rate of sebocytes by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased sebaceous epithelial cell proliferation" EXACT []
synonym: "increased sebaceous gland acinar cell proliferation" EXACT []
is_a: MP:0014055 ! abnormal sebocyte proliferation

[Term]
id: MP:0014057
name: abnormal mammary gland stroma morphology
def: "any structural anomaly of the complex non-epithelial mammary gland tissue composed of fibrous connective tissue extracellular matrix (ECM) proteins, and a wide variety of cell types, including inter- and intralobular fibroblasts, adipocytes, endothelial cells, and innate immune cells (both macrophages and mast cells); the mammary gland stroma is the support network for the epithelium, providing both nutrients and blood supply, and immune defenses, as well as physical structure to the gland; each of the different stromal cell types secrete instructive signals that are crucial for various aspects of the development and function of the epithelium" [PMID:20702598]
synonym: "abnormal mammary stroma morphology" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology

[Term]
id: MP:0014058
name: abnormal mammary gland stroma physiology
def: "any functional anomaly of the complex non-epithelial mammary gland tissue composed of fibrous connective tissue extracellular matrix (ECM) proteins, and a wide variety of cell types, including inter- and intralobular fibroblasts, adipocytes, endothelial cells, and innate immune cells (both macrophages and mast cells); the mammary gland stroma is the support network for the epithelium, providing both nutrients and blood supply, and immune defenses, as well as physical structure to the gland; each of the different stromal cell types secrete instructive signals that are crucial for various aspects of the development and function of the epithelium" [https://orcid.org/0000-0002-6490-7723, PMID:20702598]
synonym: "abnormal mammary stroma physiology" EXACT []
is_a: MP:0001881 ! abnormal mammary gland physiology

[Term]
id: MP:0014059
name: abnormal photoreceptor connecting cilium morphology
def: "any structural anomaly of the nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the retinal photoreceptor inner and outer segments" [GO:0032391, PMID:20212494]
is_a: MP:0001004 ! abnormal retina photoreceptor morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology

[Term]
id: MP:0014060
name: abnormal platelet alpha-granule morphology
def: "any structural anomaly of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
synonym: "abnormal platelet alpha granule morphology" EXACT []
is_a: MP:0004720 ! abnormal platelet morphology

[Term]
id: MP:0014061
name: ethmocephaly
def: "the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain; ethmocephaly presents with a proboscis situated above hypoteloric orbits in the midline, microphthalmos, absent nasal structures (arrhinia) and lowset malformed ears" [PMID:23248551]
is_a: MP:0005157 ! holoprosencephaly

[Term]
id: MP:0014062
name: nervous system inclusion bodies
def: "nuclear or cytoplasmic aggregates of stainable substances within cells of the nervous system" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0014063
name: Lafora bodies
def: "abnormal presence of insoluble periodic acid-Schiff-positive deposits that contain polyglucosan, a poorly branched form of glycogen, seen in familial myoclonic epilepsy; Lafora bodies develop in many tissues, including muscle, liver, and neurons, but it is generally believed that Lafora body accumulation ultimately leads to neuronal cell death" [PMID:20538597]
synonym: "Lafora body accumulation" EXACT []
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0014064
name: argyrophilic inclusion bodies
def: "presence of abundant argyrophilic grains and coiled bodies on microscopic examination of brain tissue" [HP:0100317]
synonym: "Pick inclusion bodies" EXACT []
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0014065
name: Lewy bodies
def: "Intracytoplasmic eosinophilic neuronal inclusions seen especially in pigmented brainstem neurons and in the cortex; brainstem Lewy bodies consist of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein; cortical Lewy bodies are also composed of alpha-synuclein fibrils, but are less defined and lack halos; Lewy bodies are seen in Parkinson disease, Lewy body dementia and other forms of dementia" [ISBN:0683400088]
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0014066
name: Rosenthal fibers
def: "thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders" [HP:0100320]
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0014067
name: Hirano bodies
def: "eosinophilic intracytoplasmic inclusions which have a highly characteristic crystalloid fine structure; these inclusions occur predominantly in the neuronal processes of the CA1 area in Ammon's horn but have been noted in other areas of the nervous system; these bodies contain epitopes of actin, actin-associated proteins, tau, middle molecular weight neurofilaments subunit and a C-terminal fragment of beta-amyloid precursor protein; these inclusions have been observed in amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam, Alzheimer's disease, Pick's disease and 'normal' elderly individuals and animal models" [PMID:8208338]
is_a: MP:0014062 ! nervous system inclusion bodies

[Term]
id: MP:0014068
name: abnormal muscle glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in any muscle tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002108 ! abnormal muscle morphology
is_a: MP:0005437 ! abnormal glycogen level

[Term]
id: MP:0014069
name: abnormal skeletal muscle glycogen level
def: "any anomaly in the normal concentration of a readily converted carbohydrate reserve in skeletal muscle tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0014068 ! abnormal muscle glycogen level

[Term]
id: MP:0014070
name: abnormal cardiac muscle glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in heart muscle" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cardiomyocyte glycogen level" EXACT []
synonym: "abnormal heart muscle glycogen level" EXACT []
synonym: "abnormal myocardial glycogen level" EXACT []
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
is_a: MP:0014068 ! abnormal muscle glycogen level

[Term]
id: MP:0014071
name: increased cardiac muscle glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased cardiomyocyte glycogen level" EXACT []
synonym: "increased heart muscle glycogen level" EXACT []
synonym: "increased myocardial glycogen level" EXACT []
is_a: MP:0014070 ! abnormal cardiac muscle glycogen level
is_a: MP:0031616 ! increased muscle glycogen level

[Term]
id: MP:0014072
name: decreased cardiac muscle glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiomyocyte glycogen level" EXACT []
synonym: "decreased heart muscle glycogen level" EXACT []
synonym: "decreased myocardial glycogen level" EXACT []
is_a: MP:0014070 ! abnormal cardiac muscle glycogen level
is_a: MP:0031615 ! decreased muscle glycogen level

[Term]
id: MP:0014073
name: abnormal brain glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in brain" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0005437 ! abnormal glycogen level

[Term]
id: MP:0014074
name: increased brain glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in brain" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0014073 ! abnormal brain glycogen level

[Term]
id: MP:0014075
name: decreased brain glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in brain" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0014073 ! abnormal brain glycogen level

[Term]
id: MP:0014076
name: absent Paneth cells
def: "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent Davidoff cells" EXACT []
synonym: "absent Paneth granule cells" EXACT []
is_a: MP:0013486 ! decreased Paneth cell number

[Term]
id: MP:0014077
name: ectopic Paneth cells
def: "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "ectopic Davidoff cells" EXACT []
synonym: "ectopic Paneth granule cells" EXACT []
synonym: "mislocalized Paneth cells" EXACT []
synonym: "Paneth cell ectopia" EXACT []
is_a: MP:0004843 ! abnormal Paneth cell morphology

[Term]
id: MP:0014078
name: small intestinal villus atrophy
def: "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "atrophic small intestinal villi" EXACT []
synonym: "small intestinal villous atrophy" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014079
name: decreased small intestinal villus number
def: "fewer than normal numbers of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "decreased small intestinal villous number" EXACT []
synonym: "reduced small intestinal villous number" EXACT []
synonym: "reduced small intestinal villus number" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014080
name: fused small intestinal villi
def: "partial or complete fusion of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "intestinal villous fusion" EXACT []
synonym: "intestinal villus fusion" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014081
name: branched small intestinal villi
def: "atypical formation of branched tree-like structures in the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; branching may occur in association with increased or ectopic epithelial proliferation" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "intestinal villous branching" EXACT []
synonym: "intestinal villus branching" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014082
name: decreased small intestinal villus height
def: "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "decreased small intestinal villous height" EXACT []
synonym: "reduced small intestinal villous height" EXACT []
synonym: "reduced small intestinal villus height" EXACT []
synonym: "shortened small intestinal villi" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014083
name: blunted small intestinal villi
def: "abnormal flattening of the surface of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually due to intestinal damage or injury" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "flattened small intestinal villi" EXACT []
synonym: "intestinal villous blunting" EXACT []
synonym: "intestinal villus blunting" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014084
name: clubbed small intestinal villi
def: "club-shaped small intestinal villi with tips broader than the base; usually accompanied by cytoplasmic swelling and vacuolization" [https://orcid.org/0000-0002-6490-7723, PMID:16679353]
synonym: "club-shaped intestinal villi" EXACT []
synonym: "intestinal villous clubbing" EXACT []
synonym: "intestinal villus clubbing" EXACT []
is_a: MP:0008108 ! abnormal small intestinal villus morphology

[Term]
id: MP:0014085
name: stomach non-glandular epithelium hyperkeratosis
def: "abnormal thickening of the stratum corneum in the stratified squamous epithelium lining the distinct rodent non-glandular region of the stomach, i.e. the forestomach (aka anterior or proximal stomach); hyperkeratosis frequently accompanies epithelial hyperplasia" [http://ntp.niehs.nih.gov/nnl/alimentary/forestomach/hyperker/stomach-forestomach-hyperkeratosis-pdf_508.pdf, https://orcid.org/0000-0002-6490-7723]
synonym: "anterior stomach epithelium hyperkeratosis" EXACT []
synonym: "antrum cardiacum epithelium hyperkeratosis" EXACT []
synonym: "forestomach epithelium hyperkeratosis" EXACT []
synonym: "non-glandular stomach epithelium hyperkeratosis" EXACT []
synonym: "proximal stomach epithelium hyperkeratosis" EXACT []
synonym: "stomach cardiac antrum epithelium hyperkeratosis" EXACT []
synonym: "stomach squamous epithelium hyperkeratosis" EXACT []
is_a: MP:0000472 ! abnormal stomach non-glandular epithelium morphology

[Term]
id: MP:0014086
name: obsolete hemangioma
def: "OBSOLETE. a benign tumor characterized by blood-filled spaces lined by benign endothelial cells" [HP:0001028]
is_obsolete: true
replaced_by: MP:0002947

[Term]
id: MP:0014087
name: retrolental blood
def: "presence of blood behind the lens" [https://orcid.org/0000-0003-3691-0324]
synonym: "retrolental haemorrhage" EXACT []
synonym: "retrolental hemorrhage" EXACT []
is_a: MP:0005195 ! abnormal posterior eye segment morphology

[Term]
id: MP:0014088
name: abnormal Kimura membrane morphology
def: "any structural anomaly of the thickening of the lower surface of the tectorial membrane into which the hair bundles of the outer hair cells are imbedded" [PMID:18797289, PMID:24363064]
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0014089
name: abnormal tectorial membrane marginal band morphology
def: "any structural anomaly of the dense thickening of the lateral edge of the tectorial membrane" [PMID:18797289, PMID:24363064]
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0014090
name: abnormal tectorial membrane covernet morphology
def: "any structural anomaly of the anastomosing network of large caliber fibrils that run predominantly longitudinally over the upper surface of the tectorial membrane; in mice, the covernet fibrils are continuous with the underlying striated-sheet matrix of the TM, and appear as electron-dense rods that can be a micron or more in diameter" [PMID:18797289, PMID:24363064]
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0014091
name: abnormal tectorial membrane striated-sheet matrix morphology
def: "any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]
is_a: MP:0003149 ! abnormal tectorial membrane morphology

[Term]
id: MP:0014092
name: abnormal pancreatic primary cilium morphology
def: "any structural anomaly of the nonmotile primary cilia that assemble in the normal duct, islet, and centroacinar cells of the pancreas and function in sensing and signal transduction" [PMID:24861006, PMID:24864023]
is_a: MP:0001944 ! abnormal pancreas morphology
is_a: MP:0013205 ! abnormal nonmotile primary cilium morphology

[Term]
id: MP:0014093
name: decreased pancreatic primary cilium length
def: "reduced length of the nonmotile primary cilia that are found in the normal duct, islet, and centroacinar cells of the pancreas and function in sensing and signal transduction" [PMID:24861006, PMID:24864023]
synonym: "shortened pancreatic primary cilia" EXACT []
synonym: "shortened pancreatic primary cilium" EXACT []
is_a: MP:0014092 ! abnormal pancreatic primary cilium morphology

[Term]
id: MP:0014094
name: decreased pancreatic primary cilium number
def: "reduced number of the nonmotile primary cilia that are found in the normal duct, islet, and centroacinar cells of the pancreas and function in sensing and signal transduction" [PMID:24861006, PMID:24864023]
synonym: "reduced pancreatic primary cilium number" EXACT []
is_a: MP:0014092 ! abnormal pancreatic primary cilium morphology

[Term]
id: MP:0014095
name: decreased pancreatic acinar cell zymogen granule number
def: "fewer than the expected number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced pancreatic acinar cell zymogen granule number" EXACT []
is_a: MP:0009160 ! abnormal pancreatic acinar cell zymogen granule morphology

[Term]
id: MP:0014096
name: abnormal pancreatic amylase secretion
def: "anomaly in the production and/or release of alpha-amylase, the main starch digesting enzyme component of pancreatic juice, from the acinar cells of the exocrine pancreas; pancreatic alpha-amylase is released into pancreatic ducts in its active form and acts at random locations along the starch chain to break down long-chain carbohydrates, ultimately yielding maltotriose and maltose from amylose, or maltose, glucose and limit dextrin from amylopectin" [http://en.wikipedia.org/wiki/Amylase, http://www.newworldencyclopedia.org/entry/Pancreas]
comment: Amylase is present in salivary gland secretions and in pancreatic acinar cell secretions in most mammals.
synonym: "abnormal pancreatic alpha-amylase secretion" EXACT []
is_a: MP:0002694 ! abnormal pancreas secretion
is_a: MP:0009147 ! abnormal pancreatic acinar cell physiology

[Term]
id: MP:0014097
name: increased pancreatic amylase secretion
def: "greater production and/or release of alpha-amylase, the main starch digesting enzyme component of pancreatic juice, from the acinar cells of the exocrine pancreas; pancreatic alpha-amylase is released into pancreatic ducts in its active form and acts at random locations along the starch chain to break down long-chain carbohydrates, ultimately yielding maltotriose and maltose from amylose, or maltose, glucose and limit dextrin from amylopectin" [http://en.wikipedia.org/wiki/Amylase, http://www.newworldencyclopedia.org/entry/Pancreas]
comment: Amylase is present in salivary gland secretions and in pancreatic acinar cell secretions in most mammals.
synonym: "increased pancreatic alpha-amylase secretion" EXACT []
is_a: MP:0014096 ! abnormal pancreatic amylase secretion

[Term]
id: MP:0014098
name: decreased pancreatic amylase secretion
def: "reduction in the production and/or release of alpha-amylase, the main starch digesting enzyme component of pancreatic juice, from the acinar cells of the exocrine pancreas; pancreatic alpha-amylase is released into pancreatic ducts in its active form and acts at random locations along the starch chain to break down long-chain carbohydrates, ultimately yielding maltotriose and maltose from amylose, or maltose, glucose and limit dextrin from amylopectin" [http://en.wikipedia.org/wiki/Amylase, http://www.newworldencyclopedia.org/entry/Pancreas]
comment: Amylase is present in salivary gland secretions and in pancreatic acinar cell secretions in most mammals.
synonym: "decreased pancreatic alpha-amylase secretion" EXACT []
synonym: "reduced pancreatic alpha-amylase secretion" EXACT []
is_a: MP:0014096 ! abnormal pancreatic amylase secretion

[Term]
id: MP:0014099
name: abnormal chondrocyte proliferation
def: "any anomaly in multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
synonym: "abnormal cartilage cell proliferation" EXACT []
synonym: "abnormal chondrocyte cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0009780 ! abnormal chondrocyte physiology

[Term]
id: MP:0014100
name: increased chondrocyte proliferation
def: "increased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
synonym: "increased cartilage cell proliferation" EXACT []
synonym: "increased chondrocyte cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0014099 ! abnormal chondrocyte proliferation

[Term]
id: MP:0014101
name: decreased chondrocyte proliferation
def: "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
synonym: "decreased cartilage cell proliferation" EXACT []
synonym: "decreased chondrocyte cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0014099 ! abnormal chondrocyte proliferation

[Term]
id: MP:0014102
name: abnormal chondrocyte apoptosis
def: "change in the timing or the number of chondrocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "abnormal cartilage cell apoptosis" EXACT []
synonym: "abnormal chondrocyte cell apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0009780 ! abnormal chondrocyte physiology

[Term]
id: MP:0014103
name: increased chondrocyte apoptosis
def: "increased number of chondrocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "increased cartilage cell apoptosis" EXACT []
synonym: "increased chondrocyte cell apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0014102 ! abnormal chondrocyte apoptosis

[Term]
id: MP:0014104
name: decreased chondrocyte apoptosis
def: "reduced number of chondrocytes undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "decreased cartilage cell apoptosis" EXACT []
synonym: "decreased chondrocyte cell apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0014102 ! abnormal chondrocyte apoptosis

[Term]
id: MP:0014105
name: abnormal chondrocyte differentiation
def: "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
synonym: "abnormal cartilage cell differentiation" EXACT []
synonym: "abnormal chondrocyte cell differentiation" EXACT []
is_a: MP:0000166 ! abnormal chondrocyte morphology
is_a: MP:0002113 ! abnormal skeleton development

[Term]
id: MP:0014106
name: delayed chondrocyte differentiation
def: "delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
synonym: "delayed cartilage cell differentiation" EXACT []
synonym: "delayed chondrocyte cell differentiation" EXACT []
is_a: MP:0014105 ! abnormal chondrocyte differentiation

[Term]
id: MP:0014107
name: premature chondrocyte differentiation
def: "early occurance of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
synonym: "premature cartilage cell differentiation" EXACT []
synonym: "premature chondrocyte cell differentiation" EXACT []
is_a: MP:0014105 ! abnormal chondrocyte differentiation

[Term]
id: MP:0014108
name: calcified pancreas
def: "pathologic deposition of calcium salts in the pancreas; commonly seen in chronic pancreatitis" [https://orcid.org/0000-0002-6490-7723]
synonym: "pancreas calcification" EXACT []
synonym: "pancreatic calcification" EXACT []
is_a: MP:0001944 ! abnormal pancreas morphology

[Term]
id: MP:0014109
name: increased pancreatic alpha cell proliferation
def: "increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased glucagon-secreting cell proliferation" EXACT []
synonym: "increased pancreatic A cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0003563 ! abnormal pancreatic alpha cell physiology

[Term]
id: MP:0014110
name: absent ventral pancreas
def: "absence of the transient embryonic structure that fuses with the dorsal pancreas during development to form a single organ; the ventral pancreatic bud gives rise to the pancreatic head and uncinate process" [PMID:23909279]
synonym: "absent ventral pancreatic anlagen" EXACT []
synonym: "absent ventral pancreatic bud" EXACT []
synonym: "ventral pancreatic bud agenesis" EXACT []
is_a: MP:0013867 ! abnormal ventral pancreas morphology

[Term]
id: MP:0014111
name: small ventral pancreas
def: "reduced size of the transient embryonic structure that fuses with the dorsal pancreas during development to form a single organ; the ventral pancreatic bud gives rise to the pancreatic head and uncinate process" [PMID:23909279]
synonym: "small ventral pancreatic bud" EXACT []
is_a: MP:0013867 ! abnormal ventral pancreas morphology

[Term]
id: MP:0014112
name: absent dorsal pancreas
def: "absence of the transient embryonic structure that fuses with the ventral pancreas during development to form a single organ; the dorsal pancreatic bud gives rise to the body, tail, and isthmus of the pancreas" [PMID:23909279]
synonym: "absent dorsal pancreatic anlagen" EXACT []
synonym: "absent dorsal pancreatic bud" EXACT []
synonym: "dorsal pancreatic bud agenesis" EXACT []
is_a: MP:0013866 ! abnormal dorsal pancreas morphology

[Term]
id: MP:0014113
name: small dorsal pancreas
def: "reduced size of the transient embryonic structure that fuses with the ventral pancreas during development to form a single organ; the dorsal pancreatic bud gives rise to the body, tail, and isthmus of the pancreas" [PMID:23909279]
synonym: "decreased dorsal pancreatic anlagen size" EXACT []
synonym: "decreased dorsal pancreatic bud size" EXACT []
synonym: "reduced dorsal pancreatic anlagen size" EXACT []
synonym: "reduced dorsal pancreatic bud size" EXACT []
is_a: MP:0013866 ! abnormal dorsal pancreas morphology

[Term]
id: MP:0014114
name: abnormal cognition
def: "any anomaly in the operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory" [GO:0050890]
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0014115
name: cognitive inflexibility
def: "inability to change attention or a cognitive behavior as an adaptation to the demands of external stimuli" [PMID:26112128]
synonym: "behavioral inflexibility" BROAD []
synonym: "behavioural inflexibility" BROAD []
synonym: "impaired attention switching" BROAD []
synonym: "impaired mental flexibility" EXACT []
synonym: "impaired task switching behavior" EXACT []
synonym: "impaired task switching behaviour" EXACT []
is_a: MP:0014114 ! abnormal cognition

[Term]
id: MP:0014116
name: abnormal pancreatic beta cell apoptosis
def: "change in the timing or the number of pancreatic beta cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003562 ! abnormal pancreatic beta cell physiology
is_a: MP:0009488 ! abnormal pancreatic islet cell apoptosis

[Term]
id: MP:0014117
name: increased pancreatic beta cell apoptosis
def: "increase in the number of pancreatic beta cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0014116 ! abnormal pancreatic beta cell apoptosis
is_a: MP:0014121 ! increased pancreatic islet cell apoptosis

[Term]
id: MP:0014118
name: decreased pancreatic beta cell apoptosis
def: "decrease in the number of pancreatic beta cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced pancreatic beta cell apoptosis" EXACT []
is_a: MP:0014116 ! abnormal pancreatic beta cell apoptosis
is_a: MP:0014122 ! decreased pancreatic islet cell apoptosis

[Term]
id: MP:0014119
name: abnormal mandibular nerve innervation pattern
def: "any changes in the placement, morphology or number of mandibular nerve fibers providing motor and sensory nerve supply from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini" [ISBN:0683400088]
is_a: MP:0009800 ! abnormal mandibular nerve morphology

[Term]
id: MP:0014120
name: focal seizures
def: "seizures characterized by localized cerebral ictal onset" [ISBN:0683400088]
synonym: "localized seizures" EXACT []
synonym: "partial seizure" EXACT []
is_a: MP:0002064 ! seizures

[Term]
id: MP:0014121
name: increased pancreatic islet cell apoptosis
def: "increase in the number of pancreatic islet cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009488 ! abnormal pancreatic islet cell apoptosis

[Term]
id: MP:0014122
name: decreased pancreatic islet cell apoptosis
def: "decrease in the number of pancreatic islet cells undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced pancreatic islet cell apoptosis" EXACT []
is_a: MP:0009488 ! abnormal pancreatic islet cell apoptosis

[Term]
id: MP:0014123
name: abnormal amylin secretion
def: "any anomaly in the production or release of the polypeptide hormone that is co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
synonym: "abnormal IAPP secretion" EXACT []
synonym: "abnormal islet amyloid polypeptide secretion" EXACT []
is_a: MP:0003562 ! abnormal pancreatic beta cell physiology
is_a: MP:0014195 ! abnormal endocrine pancreas secretion

[Term]
id: MP:0014124
name: increased amylin secretion
def: "greater than normal production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
synonym: "increased IAPP secretion" EXACT []
synonym: "increased islet amyloid polypeptide secretion" EXACT []
is_a: MP:0014123 ! abnormal amylin secretion

[Term]
id: MP:0014125
name: decreased amylin secretion
def: "reduction in the production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
synonym: "decreased IAPP secretion" EXACT []
synonym: "decreased islet amyloid polypeptide secretion" EXACT []
synonym: "reduced IAPP secretion" EXACT []
synonym: "reduced islet amyloid polypeptide secretion" EXACT []
is_a: MP:0014123 ! abnormal amylin secretion

[Term]
id: MP:0014126
name: increased mammary gland apoptosis
def: "increase in the number of any cells of a mammary gland undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001881 ! abnormal mammary gland physiology

[Term]
id: MP:0014127
name: increased thymoma incidence
def: "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
synonym: "thymoma" RELATED []
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence

[Term]
id: MP:0014128
name: increased Harderian gland adenocarcinoma incidence
def: "greater than the expected number of a malignant neoplasm of acinar epithelial cells in the Harderian gland, occurring in a specific population in a given time period; these usually are larger than adenomas and may cause facial selling and/or exophthalmos; they are highly cellular and disorganized compared to adenomas, with piling up of pleomorphic cells; areas of medullary or solid growth patterns are common; there may necrosis or hemorrhage, invasion beyond the orbit, and distant metastasis to the lungs, local lymph nodes, thymus or liver" [ISBN:0080467717]
synonym: "Harderian adenocarcinoma" RELATED []
synonym: "Harderian gland adenocarcinoma" RELATED []
is_a: MP:0012437 ! increased Harderian gland tumor incidence

[Term]
id: MP:0014129
name: thymus fibrosis
def: "invasion of fibrous connective tissue into the thymus, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "thymic fibrosis" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology

[Term]
id: MP:0014130
name: thymus cyst
def: "presence of one or more fluid-filled spaces lined by epithelium within the thymus" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
comment: Thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes.
synonym: "cystic thymus" EXACT []
synonym: "thymic cyst" EXACT []
synonym: "thymic cysts" EXACT []
synonym: "thymus cysts" EXACT []
is_a: MP:0000703 ! abnormal thymus morphology
is_a: MP:0031310 ! abnormal cyst

[Term]
id: MP:0014131
name: abnormal tear film morphology
def: "any alteration in the structure, biochemical composition, or stability of the thin acellular fluid layer that adheres to the most superficial layer of the corneal epithelium and lubricates and protects the ocular surface; the film is generally composed of three layers: (i) an inner mucous layer, secreted largely by the conjunctival goblet cells with contributions from the lacrimal glands, which coats the cornea, provides a hydrophobic layer, and allows for even distribution of the tear film; (ii) a middle aqueous layer, secreted by the lacrimal glands, which keeps the corneal surface moist, and provides a mechanism for oxygenation and nutrient exchange with the avascular anterior corneal tissue; and (iii) an outer lipid layer, secreted principally by the Meibomian (tarsal) glands although lipid tear elements also are contributed by the Harderian glands; tear film lipids form a monolayer on the tear surface, and function by enhancing the surface tension which supports the integrity of the tear film against collapse due to gravity and also slows down the loss of the tear film by evaporation; in addition , the lipid layer provides a glassy, smooth interface between the air and the transparent cornea" [http://en.wikipedia.org/wiki/Tears, ISBN:0124157653]
synonym: "abnormal precorneal film morphology" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology
is_a: MP:0013754 ! abnormal ocular surface morphology

[Term]
id: MP:0014132
name: abnormal tear film physiology
def: "any functional anomaly of the thin acelullar fluid layer that covers the anterior surface of the mammalian eye and has a variety of constituents that are essential for the maintenance of the avascular transparent corneal epithelium; this film keeps the cornea wet, thus allowing gas exchange between the air and the epithelium, it cleans debris from the transparent surface, providing a clear optical path to the retina, and protects the ocular surface from invasion by bacteria and viruses; the tear film also provides essential metabolites such as retinol, which serves to preserve the transparent nature of the epithelium" [PMID:11390770]
synonym: "abnormal precorneal film physiology" EXACT []
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0014133
name: obsolete abnormal Pavlovian conditioned approach
def: "any anomaly in propensity to attribute motivational properties to stimuli which predict reward; critical component of drug addition" [MPD:Molly]
comment: Withdrawn one day after initial request at submitter request
is_obsolete: true

[Term]
id: MP:0014134
name: abnormal embryo morphology
def: "any structural anomaly of an embryo" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005380 ! embryo phenotype

[Term]
id: MP:0014135
name: abnormal extraembryonic mesoderm morphology
def: "any structural anomaly of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion, yolk sac, and body stalk" [ISBN:0803606559]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0014136
name: abnormal extraembryonic endoderm morphology
def: "any structural anomaly of the derivative of the hypoblast cells that migrate into the blastocyst cavity, and line the cavity, giving rise to the primary and definitive yolk sacs; the extraembryonic endoderm fills the remaining cavity of the blastocyst" [http://discovery.lifemapsc.com/in-vivo-development/hypoblast/extraembryonic-endoderm]
is_a: MP:0002086 ! abnormal extraembryonic tissue morphology

[Term]
id: MP:0014137
name: abnormal preimplantation embryo morphology
def: "any structural anomaly of an embryo between fertilization and implantation" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pre-implantation embryo morphology" EXACT []
is_a: MP:0014134 ! abnormal embryo morphology

[Term]
id: MP:0014138
name: abnormal germ layer morphology
def: "any structural anomaly of the layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation" [ISBN:0-683-40008-8]
is_a: MP:0002085 ! abnormal embryonic tissue morphology

[Term]
id: MP:0014139
name: abnormal ectoderm morphology
def: "primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue" [UBERON:0000924]
synonym: "abnormal germinal layer morphology" EXACT []
is_a: MP:0014138 ! abnormal germ layer morphology

[Term]
id: MP:0014140
name: abnormal endoderm morphology
def: "any structural anomaly of the primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut" [UBERON:0000925]
is_a: MP:0014138 ! abnormal germ layer morphology

[Term]
id: MP:0014141
name: abnormal mesoderm morphology
def: "any structural anomaly of the middle germ layer of the embryo, between the endoderm and ectoderm" [UBERON:0000926]
is_a: MP:0014138 ! abnormal germ layer morphology

[Term]
id: MP:0014142
name: increased body fat mass
def: "increased physical bulk or volume of fat in the whole body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012320 ! abnormal body fat mass

[Term]
id: MP:0014143
name: decreased body fat mass
def: "decreased physical bulk or volume of fat in the whole body" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0012320 ! abnormal body fat mass

[Term]
id: MP:0014144
name: abnormal white adipose tissue mass
def: "aberrant physical bulk or volume of white adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002970 ! abnormal white adipose tissue morphology

[Term]
id: MP:0014145
name: increased white adipose tissue mass
def: "increased physical bulk or volume of white adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014144 ! abnormal white adipose tissue mass

[Term]
id: MP:0014146
name: decreased white adipose tissue mass
def: "decreasd physical bulk or volume of white adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced white adipose tissue mass" EXACT []
is_a: MP:0014144 ! abnormal white adipose tissue mass

[Term]
id: MP:0014147
name: lacrimal gland necrosis
def: "morphological changes resulting from pathological death of lacrimal gland tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "lachrymal gland necrosis" EXACT []
synonym: "necrotic lachrymal gland" EXACT []
synonym: "necrotic lachrymal glands" EXACT []
synonym: "necrotic lacrimal gland" EXACT []
synonym: "necrotic lacrimal glands" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0014148
name: lacrimal gland degeneration
def: "a retrogressive impairment of function or destruction of the tubuloacinar exocrine glands that secrete the aqueous layer of the tear film (tears); mice have two lacrimal glands (intra- and exorbital)" [https://orcid.org/0000-0002-6490-7723]
synonym: "lachrymal gland degeneration" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0014149
name: abnormal lacrimal gland innervation pattern
def: "any structural or position anomaly of the supply of nerve fibers that connect to the tubuloacinar exocrine glands that secrete the aqueous layer of the tear film (tears)" [https://en.wikipedia.org/wiki/Lacrimal_gland, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002184 ! abnormal innervation

[Term]
id: MP:0014150
name: lacrimal gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in the lacrimal gland, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic lachrymal glands" EXACT []
synonym: "hyperplastic lacrimal glands" EXACT []
synonym: "lachrymal gland hyperplasia" EXACT []
is_a: MP:0013453 ! enlarged lacrimal gland

[Term]
id: MP:0014151
name: lacrimal gland hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lacrimal gland, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic lacrimal gland" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0014152
name: absent exorbital lacrimal gland
def: "absence of the large extra-orbital lacrimal gland that, in mice, is normally located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent exorbital lachrymal gland" EXACT []
synonym: "absent extra-orbital lachrymal gland" EXACT []
synonym: "absent extra-orbital lacrimal gland" EXACT []
is_a: MP:0013440 ! abnormal exorbital lacrimal gland morphology

[Term]
id: MP:0014153
name: absent intraorbital lacrimal gland
def: "absence of the small intra-orbital lacrimal gland that, in mice, is normally located superficially at the lateral canthus, where both the lacrimal gland and Harderian gland ducts open" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent intra-orbital lachrymal gland" EXACT []
synonym: "absent intra-orbital lacrimal gland" EXACT []
synonym: "absent intraorbital lachrymal gland" EXACT []
is_a: MP:0013441 ! abnormal intraorbital lacrimal gland morphology

[Term]
id: MP:0014154
name: Meibomian gland degeneration
def: "a retrogressive impairment of function or destruction of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [ISBN:0-683-40008-8]
synonym: "tarsal gland degeneration" EXACT []
is_a: MP:0005252 ! abnormal Meibomian gland morphology

[Term]
id: MP:0014155
name: absent olfactory epithelium
def: "absence of the epithelial cells that line the interior of the nose" [https://orcid.org/0000-0003-3691-0324]
synonym: "absent nasal epithelium" EXACT []
is_a: MP:0008789 ! abnormal olfactory epithelium morphology

[Term]
id: MP:0014156
name: abnormal lacrimal gland myoepithelium morphology
def: "any structural anomaly of the stellate-shaped contractile cells with flattened nuclei and long slender processes that surround the secretory acini and intralobular ducts of the lacrimal gland, located between the epithelium and the basement membrane; myoepithelial cells not only exhibit characteristics of other epithelial cells, such as expression of cytokeratin, but also exhibit properties of smooth muscle cells, such as expression of alpha-smooth muscle actin; their contraction might aid in the expulsion of fluid out of the secretory tubules or help maintain the patency of acinar and ductal lumens" [ISBN:0123820081, ISBN:0123820421, ISBN:0781742064]
synonym: "abnormal lacrimal gland myoepithelial cell morphology" EXACT []
synonym: "abnormal lacrimal myoepithelium morphology" EXACT []
synonym: "abnormal lacrymal gland myoepithelial cell morphology" EXACT []
synonym: "abnormal lacrymal gland myoepithelium morphology" EXACT []
synonym: "abnormal lacrymal myoepithelium morphology" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology

[Term]
id: MP:0014157
name: alacrima
def: "absence of tear production; may occur in association with other disorders or as an isolated congenital defect" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of lachrymal fluids" EXACT []
synonym: "absence of lacrimal fluids" EXACT []
synonym: "absence of tear secretion" EXACT []
synonym: "absence of tears" EXACT []
is_a: MP:0020218 ! abnormal tear production

[Term]
id: MP:0014158
name: esophagus fibrosis
def: "invasion of fibrous connective tissue into the esophagus, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "esophageal fibrosis" EXACT []
synonym: "oesophageal fibrosis" EXACT []
synonym: "oesophagus fibrosis" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology

[Term]
id: MP:0014159
name: stomach fibrosis
def: "invasion of fibrous connective tissue into the stomach, often resulting from inflammation or injury" [https://orcid.org/0000-0003-3691-0324]
synonym: "gastric fibrosis" EXACT []
is_a: MP:0000470 ! abnormal stomach morphology

[Term]
id: MP:0014160
name: abnormal circulating cortisol level
def: "any anomaly in the blood concentration of the principal glucocorticoid produced by the zona fasciculata of the adrenal cortex within the adrenal gland; cortisol is released in response to stress and a low level of blood glucose; it functions to increase blood sugar through gluconeogenesis, to suppress the immune system, and to aid the metabolism of fat, protein, and carbohydrate; it also decreases bone formation" [https://en.wikipedia.org/wiki/Cortisol]
is_a: MP:0003366 ! abnormal circulating glucocorticoid level

[Term]
id: MP:0014161
name: increased circulating cortisol level
def: "greater than the normal blood concentration of the principal glucocorticoid produced by the zona fasciculata of the adrenal cortex within the adrenal gland and released in response to stress and a low level of blood glucose" [https://en.wikipedia.org/wiki/Cortisol]
synonym: "increased plasma cortisol level" NARROW []
synonym: "increased serum cortisol level" NARROW []
is_a: MP:0014160 ! abnormal circulating cortisol level

[Term]
id: MP:0014162
name: decreased circulating cortisol level
def: "less than the normal blood concentration of the principal glucocorticoid produced by the zona fasciculata of the adrenal cortex within the adrenal gland and released in response to stress and a low level of blood glucose" [https://en.wikipedia.org/wiki/Cortisol]
synonym: "decreased plasma cortisol level" NARROW []
synonym: "decreased serum cortisol level" NARROW []
is_a: MP:0014160 ! abnormal circulating cortisol level

[Term]
id: MP:0014163
name: abnormal ciliary muscle morphology
def: "any structural anomaly of the ring of smooth muscle in the eye's vascular layer that forms the main part of the ciliary body, controls accommodation for viewing objects at varying distances, and regulates the flow of aqueous humor into the canal of Schlemm" [http://medical-dictionary.thefreedictionary.com/ciliary+muscle, https://en.wikipedia.org/wiki/Ciliary_muscle]
is_a: MP:0003687 ! abnormal intraocular muscle morphology
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0014164
name: abnormal ciliary process morphology
def: "any structural anomaly of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; these processes increase in thickness as they advance from the orbiculus ciliaris to the external border of the iris, and together with the folds (plicae) in the furrows between them, constitute the corona ciliaris; ciliary processes produce aqueous humor" [http://www.medilexicon.com/medicaldictionary.php?s=processus+ciliaris]
synonym: "abnormal processus ciliaris morphology" EXACT []
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0014165
name: absent ciliary process
def: "absence or loss of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; ciliary processes produce aqueous humor" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014164 ! abnormal ciliary process morphology

[Term]
id: MP:0014166
name: ectopic cranial bone
def: "the appearance of an extra bone structure at an atypical location in or near the cranium" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0000438 ! abnormal cranium morphology
is_a: MP:0014167 ! ectopic bone

[Term]
id: MP:0014167
name: ectopic bone
def: "the appearance of an extra bone structure at an atypical location" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0014168
name: abnormal brown adipose tissue mass
def: "aberrant physical bulk or volume of brown adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0002971 ! abnormal brown adipose tissue morphology

[Term]
id: MP:0014169
name: decreased brown adipose tissue mass
def: "decreased physical bulk or volume of brown adipose tissue" [https://orcid.org/0000-0003-3691-0324]
synonym: "reduced brown adipose tissue mass" EXACT []
is_a: MP:0014168 ! abnormal brown adipose tissue mass

[Term]
id: MP:0014170
name: increased brown adipose tissue mass
def: "increased physical bulk or volume of brown adipose tissue" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014168 ! abnormal brown adipose tissue mass

[Term]
id: MP:0014171
name: increased fatty acid oxidation
def: "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
is_a: MP:0010953 ! abnormal fatty acid oxidation

[Term]
id: MP:0014172
name: decreased fatty acid oxidation
def: "decreased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
is_a: MP:0010953 ! abnormal fatty acid oxidation

[Term]
id: MP:0014173
name: increased fatty acid beta-oxidation
def: "increased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
is_a: MP:0010952 ! abnormal fatty acid beta-oxidation

[Term]
id: MP:0014174
name: decreased fatty acid beta-oxidation
def: "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
is_a: MP:0010952 ! abnormal fatty acid beta-oxidation

[Term]
id: MP:0014175
name: abnormal ciliary epithelium morphology
def: "any structural anomaly of the double layer lining the inner surfaces of the ciliary processes and the pars plana (i.e. the posterior portion of the ciliary body, aka orbicularis ciliari); the outer layer is the pigmented epithelium, which is composed of low cuboidal cells and is adjacent to the stroma and continuous with the retinal pigmented epithelium; the inner layer is formed by non-pigmented epithelium, a columnar epithelium, adjacent to the aqueous humor in the posterior chamber and continuous with the retina; these two layers of the epithelium are appositioned in their apical surfaces" [http://cdn.intechopen.com/pdfs-wm/41830.pdf]
synonym: "abnormal ciliary body epithelium morphology" EXACT []
synonym: "abnormal epithelium of ciliary body morphology" EXACT []
synonym: "abnormal ocular ciliary epithelium morphology" EXACT []
is_a: MP:0005099 ! abnormal ciliary body morphology

[Term]
id: MP:0014176
name: abnormal cilary zonule morphology
def: "any structural anomaly of the circumferential suspensory ligaments that anchor the lens to the ciliary process and are made of bundles of fibrillin microfibrils, an elaborate system of fibers that spans the gap between the lens and the adjacent nonpigmented ciliary epithelium; this fibrous rigging ensures lens centration; in species that accommodate, the zonule transmits the forces that flatten the lens, allowing the eye to focus on distant objects" [PMID:23493297, PMID:24908666]
synonym: "abnormal apparatus suspensorius lentis morphology" EXACT []
synonym: "abnormal suspensory ligament of lens morphology" EXACT []
synonym: "abnormal Zinn zonule morphology" EXACT []
synonym: "abnormal Zinn's zonule morphology" EXACT []
synonym: "abnormal zonula ciliaris morphology" EXACT []
is_a: MP:0005193 ! abnormal anterior eye segment morphology

[Term]
id: MP:0014177
name: abnormal Weber's gland morphology
def: "any structural anomaly of the lingual glands located on the lateral margins of the tongue, at the level of the foliate papillae and in the root of the tongue behind the circumvallate papillae; in humans, the ducts of posterior superficial lingual glands open into the crypts of lingual tonsils; mucous supplied by these glands may help to cleanse the crypts and aid in deglutition" [PMID:19166479]
synonym: "abnormal posterior superficial lingual gland morphology" EXACT []
is_a: MP:0003791 ! abnormal minor salivary gland morphology

[Term]
id: MP:0014178
name: increased brain apoptosis
def: "increase in the number of cells of the brain undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0014179
name: abnormal blood-retina barrier function
def: "anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina; the BRB barrier becomes more leaky in patients with diabetic retinopathy" [https://en.wikipedia.org/wiki/Blood%E2%80%93retinal_barrier]
synonym: "abnormal blood-retinal barrier function" EXACT []
synonym: "abnormal BRB function" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0005253 ! abnormal eye physiology

[Term]
id: MP:0014180
name: abnormal thymus apoptosis
def: "change in the timing or the number of cells located in the thymus that are undergoing programmed cell death" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0003763 ! abnormal thymus physiology

[Term]
id: MP:0014181
name: abnormal respiratory epithelial sodium ion transmembrane transport
def: "any anomaly in the directed movement of a sodium from one side of the respiratory epithelial cell membrane to the other" [GO:0035725]
is_a: MP:0014026 ! abnormal respiratory epithelial transmembrane transport

[Term]
id: MP:0014182
name: decreased respiratory epithelial sodium ion transmembrane transport
def: "decrease in the directed movement of sodium ions from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014181 ! abnormal respiratory epithelial sodium ion transmembrane transport

[Term]
id: MP:0014183
name: increased respiratory epithelial sodium ion transmembrane transport
def: "increase in the directed movement of sodium ion from one side of the respiratory epithelial cell membrane to the other" [https://orcid.org/0000-0003-3691-0324]
is_a: MP:0014181 ! abnormal respiratory epithelial sodium ion transmembrane transport

[Term]
id: MP:0014184
name: hindbrain atrophy
def: "acquired diminution of the size of the hindbrain associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic hindbrain" EXACT []
synonym: "atrophic rhombencephalon" EXACT []
synonym: "rhombencephalon atrophy" EXACT []
is_a: MP:0000841 ! abnormal hindbrain morphology
is_a: MP:0012506 ! brain atrophy

[Term]
id: MP:0014185
name: cerebellum atrophy
def: "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic cerebellum" EXACT []
synonym: "cerebellar atrophy" EXACT []
is_a: MP:0000852 ! small cerebellum
is_a: MP:0014184 ! hindbrain atrophy

[Term]
id: MP:0014186
name: epididymis hypertrophy
def: "increase in the bulk size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens due to cell enlargement" []
synonym: "epididymal hypertrophy" EXACT []
synonym: "hypertrophic epididymis" EXACT []
is_a: MP:0004931 ! enlarged epididymis

[Term]
id: MP:0014187
name: spermatocele
def: "a retention cyst of a tubule of the rete testis or the head of the epididymis distended with barely watery fluid that contains spermatozoa" [http://medical-dictionary.thefreedictionary.com/spermatocyst, https://en.wikipedia.org/wiki/Spermatocele]
synonym: "spermatoceles" EXACT []
is_a: MP:0009205 ! abnormal internal male genitalia morphology

[Term]
id: MP:0014188
name: epididymis fibrosis
def: "invasion of fibrous connective tissue into the epididymis, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "epididymal fibrosis" EXACT []
is_a: MP:0002631 ! abnormal epididymis morphology

[Term]
id: MP:0014189
name: testis fibrosis
def: "invasion of fibrous connective tissue into the testis, often resulting from inflammation or injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "testicular fibrosis" EXACT []
is_a: MP:0001146 ! abnormal testis morphology

[Term]
id: MP:0014190
name: abnormal epididymis physiology
def: "any functional anomaly of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal epididymal physiology" EXACT []
is_a: MP:0003698 ! abnormal male reproductive system physiology

[Term]
id: MP:0014191
name: abnormal epididymal cell proliferation
def: "anomaly in the expansion rate of any epididymal cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014190 ! abnormal epididymis physiology

[Term]
id: MP:0014192
name: increased epididymal cell proliferation
def: "increase in the expansion rate of any epididymal cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014191 ! abnormal epididymal cell proliferation

[Term]
id: MP:0014193
name: decreased epididymal cell proliferation
def: "decrease in the expansion rate of any epididymal cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced epididymal cell proliferation" EXACT []
is_a: MP:0014191 ! abnormal epididymal cell proliferation

[Term]
id: MP:0014194
name: increased epididymal epithelium cell proliferation
def: "increase in the expansion rate of the cells of the epididymal epithelium by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014192 ! increased epididymal cell proliferation

[Term]
id: MP:0014195
name: abnormal endocrine pancreas secretion
def: "anomaly in the synthesis and/or release of any of the hormones produced by different types of cells in the islets of Langerhans of the endocrine pancreas and secreted directly into the blood stream to regulate blood glucose homeostasis; these hormones include glucagon secreted by alpha cells, insulin and amylin (also known as Islet Amyloid Polypeptide or IAPP) co-secreted by beta cells, somatostatin secreted by delta cells, gherlin secreted by epsilon cells, and pancreatic polypeptide secreted by PP cells (also known as F cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal endocrine pancreatic secretion" EXACT []
is_a: MP:0002694 ! abnormal pancreas secretion

[Term]
id: MP:0014198
name: absent pituitary infundibular stalk
def: "absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent hypophyseal stalk" EXACT []
synonym: "absent infundibular stem" EXACT []
synonym: "absent pituitary infundibulum" EXACT []
is_a: MP:0009463 ! abnormal pituitary infundibular stalk morphology

[Term]
id: MP:0014199
name: abnormal parotid gland myoepithelium morphology
def: "any structural anomaly of the stellate-shaped contractile cells with long dendritic processes that surround the secretory acini and intercalated ducts of the parotid gland, usually found in the glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells; they display features of both smooth muscle and epithelium, such as numerous microfilaments with focal densities in the cytoplasmic processes, and desmosomes which attach them to the epithelial cells; their functions include contraction when the gland is stimulated to secrete, compressing or reinforcing the underlying parenchymal cells, thus aiding in the expulsion of saliva and preventing damage to the other cells" [http://en.wikipedia.org/wiki/Myoepithelial_cell, http://www.ccij-online.org/text.asp?2013/2/2/101/113624]
synonym: "abnormal parotid gland basket cell morphology" EXACT []
synonym: "abnormal parotid gland myoepithelial cell morphology" EXACT []
synonym: "abnormal parotid myoepithelial cell morphology" EXACT []
synonym: "abnormal parotid myoepithelium morphology" EXACT []
is_a: MP:0003452 ! abnormal parotid gland morphology

[Term]
id: MP:0014200
name: abnormal respiratory epithelium physiology
def: "any functional anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0014201
name: abnormal intestinal epithelium physiology
def: "any functional anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
is_a: MP:0010155 ! abnormal intestine physiology

[Term]
id: MP:0014202
name: abnormal intestinal epithelial transmembrane transport
def: "any anomaly in the process in which a solute is transported across the lipid bilayer of an intestinal cell, from one side of a membrane to the other" [GO:0055085]
is_a: MP:0014201 ! abnormal intestinal epithelium physiology

[Term]
id: MP:0014203
name: abnormal intestinal epithelial chloride transmembrane transport
def: "any anomaly in the process in which a calcium ion is transported from one side of a membrane of an intestinal epithelial cell to the other by means of some agent such as a transporter or pore" [GO:0070588]
is_a: MP:0014202 ! abnormal intestinal epithelial transmembrane transport

[Term]
id: MP:0014204
name: abnormal intestinal epithelial sodium ion transmembrane transport
def: "any anomaly in the process in which a sodium ion is transported from one side of a membrane of an intestinal epithelial cell to the other by means of some agent such as a transporter or pore" [GO:0035725]
is_a: MP:0014202 ! abnormal intestinal epithelial transmembrane transport

[Term]
id: MP:0014205
name: increased intestinal epithelial sodium ion transmembrane transport
def: "increase in the directed movement of a sodium ions from one side of the intestinal epithelial cell membrane to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014204 ! abnormal intestinal epithelial sodium ion transmembrane transport

[Term]
id: MP:0014206
name: decreased intestinal epithelial sodium ion transmembrane transport
def: "decrease in the directed movement of a sodium ions from one side of the intestinal epithelial cell membrane to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014204 ! abnormal intestinal epithelial sodium ion transmembrane transport

[Term]
id: MP:0014207
name: increased intestinal epithelial chloride transmembrane transport
def: "increase in the directed movement of a chloride from one side of the intestinal epithelial cell membrane to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014203 ! abnormal intestinal epithelial chloride transmembrane transport

[Term]
id: MP:0014208
name: decreased intestinal epithelial chloride transmembrane transport
def: "decrease in the directed movement of a chloride from one side of the intestinal epithelial cell membrane to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014203 ! abnormal intestinal epithelial chloride transmembrane transport

[Term]
id: MP:0014209
name: abnormal pancreatic duct epithelium physiology
def: "any functional anomaly of the epithelial layer of the pancreatic duct" [http://purl.obolibrary.org/obo/UBERON_0009970]
is_a: MP:0010148 ! abnormal exocrine pancreas physiology

[Term]
id: MP:0014210
name: abnormal pancreatic duct epithelial transmembrane transport
def: "any anomaly in the directed movement of a substance from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [http://purl.obolibrary.org/obo/GO_0055085, http://purl.obolibrary.org/obo/GO_0070633]
is_a: MP:0014209 ! abnormal pancreatic duct epithelium physiology

[Term]
id: MP:0014211
name: abnormal pancreatic duct epithelial chloride transmembrane transport
def: "any anomaly in the directed movement of chloride from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [http://purl.obolibrary.org/obo/GO_0030321, http://purl.obolibrary.org/obo/GO_0055085]
is_a: MP:0014210 ! abnormal pancreatic duct epithelial transmembrane transport

[Term]
id: MP:0014212
name: decreased pancreatic duct epithelial chloride transmembrane transport
def: "reduction in the directed movement of chloride from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [] {def="https://orcid.org/0000-0003-4606-0597"}
is_a: MP:0014211 ! abnormal pancreatic duct epithelial chloride transmembrane transport

[Term]
id: MP:0014213
name: increased pancreatic duct epithelial chloride transmembrane transport
def: "increase in the directed movement of chloride from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014211 ! abnormal pancreatic duct epithelial chloride transmembrane transport

[Term]
id: MP:0014214
name: abnormal pancreatic duct epithelial sodium ion transmembrane transport
def: "any anomaly in the directed movement of sodium ions from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [http://purl.obolibrary.org/obo/GO_0055085]
is_a: MP:0014210 ! abnormal pancreatic duct epithelial transmembrane transport

[Term]
id: MP:0014215
name: increased pancreatic duct epithelial sodium ion transmembrane transport
def: "increase in the directed movement of sodium ions from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014214 ! abnormal pancreatic duct epithelial sodium ion transmembrane transport

[Term]
id: MP:0014216
name: decreased pancreatic duct epithelial sodium ion transmembrane transport
def: "reduction in the directed movement of sodium ions from one side of the lipid bilayer of the epithelium of the pancreatic duct to the other" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014214 ! abnormal pancreatic duct epithelial sodium ion transmembrane transport

[Term]
id: MP:0014217
name: abnormal intestinal mucosa thickness
def: "anomaly in the width of the mucosal layer that lines the intestine" [http://purl.obolibrary.org/obo/UBERON_0001242]
synonym: "abnormal bowel mucosa thickness" EXACT []
synonym: "abnormal intestine mucosa thickness" EXACT []
is_a: MP:0000511 ! abnormal intestinal mucosa morphology

[Term]
id: MP:0014218
name: increased intestinal mucosa thickness
def: "increase in the width of the mucosal layer that lines the intestine" [http://purl.obolibrary.org/obo/UBERON_0001242]
synonym: "increased bowel mucosa thickness" EXACT []
synonym: "increased mucosa of intestine thickness" EXACT []
synonym: "thick intestine mucosa" EXACT []
is_a: MP:0014217 ! abnormal intestinal mucosa thickness

[Term]
id: MP:0014219
name: decreased intestinal mucosa thickness
def: "decrease in the width of the mucosal layer that lines the intestine" [http://purl.obolibrary.org/obo/UBERON_0001242]
synonym: "decreased bowel mucosa thickness" EXACT []
synonym: "reduced mucosa of intestine thickness" EXACT []
synonym: "thin intestine mucosa" EXACT []
is_a: MP:0014217 ! abnormal intestinal mucosa thickness

[Term]
id: MP:0014220
name: abnormal colon goblet cell number
def: "any anomaly in the number of goblet cells in the colon" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013795 ! abnormal colon goblet cell morphology

[Term]
id: MP:0014221
name: increased colon goblet cell number
def: "increase in the number of goblet cells in the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "colon goblet cell hyperplasia" EXACT []
is_a: MP:0014220 ! abnormal colon goblet cell number

[Term]
id: MP:0014222
name: decreased colon goblet cell number
def: "reduction in the number of goblet cells in the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "colon goblet cell hypoplasia" EXACT []
synonym: "reduced colon goblet cell number" EXACT []
is_a: MP:0014220 ! abnormal colon goblet cell number

[Term]
id: MP:0014223
name: abnormal ileal goblet cell number
def: "any anomaly in the number of goblet cells in the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal ileum goblet cell number" EXACT []
is_a: MP:0002581 ! abnormal ileum morphology

[Term]
id: MP:0014224
name: increased ileal goblet cell number
def: "increase in the number of goblet cells in the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "ileal goblet cell hyperplasia" EXACT []
synonym: "increased ileum goblet cell number" EXACT []
is_a: MP:0014223 ! abnormal ileal goblet cell number

[Term]
id: MP:0014225
name: decreased ileal goblet cell number
def: "reduction in the number of goblet cells in the ileum" [https://orcid.org/0000-0002-6490-7723]
synonym: "ileal goblet cell hypoplasia" EXACT []
synonym: "reduced ileal goblet cell number" EXACT []
is_a: MP:0014223 ! abnormal ileal goblet cell number

[Term]
id: MP:0014226
name: abnormal alveolar macrophage physiology
def: "any functional anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583]
is_a: MP:0002133 ! abnormal respiratory system physiology

[Term]
id: MP:0014227
name: abnormal alveolar macrophage number
def: "any anomaly in the number of round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008245 ! abnormal alveolar macrophage morphology
is_a: MP:0020202 ! abnormal macrophage cell number

[Term]
id: MP:0014228
name: increased alveolar macrophage number
def: "increase in the number of round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "alveolar macrophage hyperplasia" EXACT []
synonym: "elevated alveolar macrophage number" EXACT []
is_a: MP:0014227 ! abnormal alveolar macrophage number

[Term]
id: MP:0014229
name: decreased alveolar macrophage number
def: "reduction in the number of round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "alveolar macrophage hypoplasia" EXACT []
synonym: "reduced alveolar macrophage number" EXACT []
is_a: MP:0014227 ! abnormal alveolar macrophage number

[Term]
id: MP:0014230
name: dilated crypt of Lieberkuhn
def: "an expansion in the volume or area of the lumen of one or more of the crypts of Lieberkuhn" [https://orcid.org/0000-0003-4606-0597, PMID:8605891]
synonym: "crypt of Lieberkuhn dilation" EXACT []
synonym: "dilated crypts of Lieberkuhn" EXACT []
is_a: MP:0000490 ! abnormal crypts of Lieberkuhn morphology

[Term]
id: MP:0014231
name: intestinal mucus accumulation
def: "increase in the amount of mucus contained within the lumin of the intestine" [https://orcid.org/0000-0003-4606-0597, PMID:18802965]
is_a: MP:0000477 ! abnormal intestine morphology

[Term]
id: MP:0014232
name: dilated pancreatic acinus
def: "the luminal space of one or more of the pancreatic acini are increased in volume or area, usually with an increase in contained fluid" [https://orcid.org/0000-0003-4606-0597]
synonym: "dilated pancreatic acini" EXACT []
synonym: "pancreatic acini dilation" EXACT []
synonym: "pancreatic acinus dilation" EXACT []
is_a: MP:0009145 ! abnormal pancreatic acinus morphology

[Term]
id: MP:0014233
name: bile duct epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the bile duct epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyperplastic bile duct epithelium" EXACT []
is_a: MP:0013611 ! abnormal bile duct epithelium morphology

[Term]
id: MP:0014234
name: decreased enterocyte apoptosis
def: "reduction in the timing or the number of enterocytes undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced intestinal cell apoptosis" EXACT []
synonym: "reduced intestinal epithelial cell apoptosis" EXACT []
is_a: MP:0008884 ! abnormal enterocyte apoptosis
property_value: dc:date "2023-03-02T14:20:13Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014235
name: abnormal tumor-free survival time
def: "any anomaly in the span of life of an organism or population of organisms spends free from the signs, symptoms, or occurrence of neoplasms" [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/disease-free-survival]
synonym: "abnormal tumor free survival time" EXACT []
is_a: MP:0010769 ! abnormal survival
property_value: dc:date "2023-05-19T20:27:21Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014236
name: increased tumor-free survival time
def: "increase in the length of time an organism or population of organisms spends free from the signs, symptoms, or occurrence of neoplasms" [https://orcid.org/0000-0003-4606-0597]
synonym: "prolonged tumor free survival time" EXACT []
is_a: MP:0014235 ! abnormal tumor-free survival time
property_value: dc:date "2023-05-19T20:30:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014237
name: decreased tumor-free survival time
def: "decrease in the length of time an organism or population of organisms spends free from the signs, symptoms, or occurrence of neoplasms" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced tumor free survival time" EXACT []
is_a: MP:0002083 ! premature death
is_a: MP:0014235 ! abnormal tumor-free survival time
property_value: dc:date "2023-05-19T20:32:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014238
name: abnormal ribosome morphology
def: "any anomaly in the structure of the intracellular organelle consisting of RNA and protein that is the site of protein biosynthesis resulting from translation of messenger RNA" [http://purl.obolibrary.org/obo/GO_0005840]
is_a: MP:0014239 ! abnormal intracellular organelle morphology
property_value: dc:date "2023-05-26T18:03:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014239
name: abnormal intracellular organelle morphology
def: "any anomaly in the structure of the organized components of distincive morphology and function that occur within a cell" [http://purl.obolibrary.org/obo/GO_0043229]
is_a: MP:0000358 ! abnormal cell morphology
property_value: dc:date "2023-05-26T18:09:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014240
name: abnormal ribosome physiology
def: "any functional anomaly in the intracellular organelle consisting of RNA and protein that is the site of protein biosynthesis resulting from translation of messenger RNA" [http://purl.obolibrary.org/obo/GO_0005840]
synonym: "abnormal ribosomal physiology" EXACT []
is_a: MP:0014241 ! abnormal intracellular organelle physiology
property_value: dc:date "2023-05-26T18:21:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014241
name: abnormal intracellular organelle physiology
def: "any functional anomaly in the organized components of distincive morphology and function that occur within a cell" [] {comment="GO:0043229"}
is_a: MP:0005621 ! abnormal cell physiology
property_value: dc:date "2023-05-26T18:25:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014242
name: abnormal ribosome biogenesis
def: "any anomaly in the process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; including transport to the sites of protein synthesis" [http://purl.obolibrary.org/obo/GO_0042254]
synonym: "abnormal ribosomal biogenesis and assembly" EXACT []
is_a: MP:0014240 ! abnormal ribosome physiology
property_value: dc:date "2023-05-26T18:37:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014243
name: abnormal ribosome assembly
def: "any anomaly in the process that results in the aggregation, arrangement and bonding together of the mature ribosome and of its subunits" [http://purl.obolibrary.org/obo/GO_0042255]
synonym: "abnormal ribosomal subunit assembly" EXACT []
is_a: MP:0014242 ! abnormal ribosome biogenesis
property_value: dc:date "2023-05-26T18:40:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014244
name: abnormal cellular ATP level
def: "anomaly in the amount of the major energy source adenosine triphosphate inside cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cellular adenosine triphosphate level" EXACT []
is_a: MP:0000358 ! abnormal cell morphology
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:date "2023-05-26T19:49:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014245
name: increased cellular ATP level
def: "elevated concentration of the major energy source adenosine triphosphate inside cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated cellular ATP level" EXACT []
is_a: MP:0014244 ! abnormal cellular ATP level
property_value: dc:date "2023-05-26T19:51:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014246
name: decreased cellular ATP level
def: "reduced concentration of the major energy source adenosine triphosphate inside cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced cellular ATP level" EXACT []
is_a: MP:0014244 ! abnormal cellular ATP level
property_value: dc:date "2023-05-26T19:51:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014247
name: long photoreceptor inner segment
def: "increased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased photoreceptor inner segment length" EXACT []
is_a: MP:0003730 ! abnormal photoreceptor inner segment morphology
property_value: dc:date "2023-05-31T18:41:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014248
name: thin retina nerve fiber layer
def: "decreased thickness of the retinal layer formed by expansion of the fibers of the optic nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal nerve fibre layer thickness" EXACT []
synonym: "reduced retinal nerve fibre layer thickness" EXACT []
synonym: "thin stratum opticum" EXACT []
is_a: MP:0006303 ! abnormal retina nerve fiber layer morphology
property_value: dc:date "2023-05-31T18:47:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014249
name: thick retina nerve fiber layer
def: "increased thickness of the retinal layer formed by expansion of the fibers of the optic nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal nerve fibre layer thickness" EXACT []
synonym: "thick stratum opticum" EXACT []
is_a: MP:0006303 ! abnormal retina nerve fiber layer morphology
property_value: dc:date "2023-05-31T18:47:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014250
name: disorganized retina nerve fiber layer
def: "derangement of the normal pattern of the retinal layer formed by expansion of the fibers of the optic nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "disorganised stratum opticum" EXACT []
synonym: "disorganized retinal nerve fibre layer" EXACT []
is_a: MP:0006303 ! abnormal retina nerve fiber layer morphology
property_value: dc:date "2023-05-31T18:48:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014251
name: absent retina nerve fiber layer
def: "absence of the retinal layer formed by expansion of the fibers of the optic nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent retinal nerve fibre layer" EXACT []
synonym: "absent stratum opticum" EXACT []
is_a: MP:0006303 ! abnormal retina nerve fiber layer morphology
property_value: dc:date "2023-05-31T18:48:21Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014252
name: abnormal paired-pulse ratio
def: "any anomaly in the response of central synapses when activated twice in rapid succession as expressed by the ratio of the amplitude of the second response to the first response" [https://doi.org/10.1016/j.brainres.2007.03.089]
synonym: "abnormal paired pulse ratio" EXACT []
synonym: "abnormal PPR" EXACT []
is_a: MP:0003635 ! abnormal synaptic transmission
property_value: dc:date "2023-06-20T17:23:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014253
name: decreased paired-pulse ratio
def: "decrease in the ratio of the amplitude of the second response to the first response in central synapses following activation twice in rapid succession" [https://doi.org/10.1016/j.brainres.2007.03.089]
synonym: "decreased paired pulse ratio" EXACT []
synonym: "reduced PPR" EXACT []
is_a: MP:0014252 ! abnormal paired-pulse ratio
property_value: dc:date "2023-06-20T17:27:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014254
name: increased paired-pulse ratio
def: "increase in the ratio of the amplitude of the second response to the first response in central synapses following activation twice in rapid succession" [https://doi.org/10.1016/j.brainres.2007.03.089]
synonym: "elevated PPR" EXACT []
synonym: "increased paired pulse ratio" EXACT []
is_a: MP:0014252 ! abnormal paired-pulse ratio
property_value: dc:date "2023-06-20T17:28:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014255
name: increased paired-pulse inhibition
def: "elevation in the suppressive response of central synapses when activated twice in rapid succession" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated PPD" EXACT []
synonym: "enhanced PPI" EXACT []
synonym: "increased paired pulse depression" EXACT []
is_a: MP:0004807 ! abnormal paired-pulse inhibition
property_value: dc:date "2023-06-20T17:41:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014256
name: decreased paired-pulse inhibition
def: "reduction in the suppressive response of central synapses when activated twice in rapid succession" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased paired pulse depression" EXACT []
synonym: "decreased PPD" EXACT []
synonym: "reduced PPI" EXACT []
is_a: MP:0004807 ! abnormal paired-pulse inhibition
property_value: dc:date "2023-06-20T17:42:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014257
name: embryonic lethality prior to tooth bud stage, complete penetrance
def: "death of all organisms prior to the appearance of tooth buds (Mus: E12-E12.5)" [https://orcid.org/0000-0003-4606-0597]
synonym: "complete embryonic lethality prior to tooth bud stage" EXACT []
is_a: MP:0011092 ! embryonic lethality, complete penetrance
is_a: MP:0013293 ! embryonic lethality prior to tooth bud stage
property_value: dc:date "2023-06-20T18:00:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014258
name: embryonic lethality prior to tooth bud stage, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms prior to the appearance of tooth buds (Mus: E12-E12.5)" [https://orcid.org/0000-0003-4606-0597]
synonym: "incomplete embryonic lethality prior to tooth bud stage" EXACT []
synonym: "partial embryonic lethality prior to tooth bud stage" EXACT []
is_a: MP:0011102 ! embryonic lethality, incomplete penetrance
is_a: MP:0013293 ! embryonic lethality prior to tooth bud stage
property_value: dc:date "2023-06-20T18:00:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014259
name: embryonic lethality prior to organogenesis, complete penetrance
def: "death of all organisms prior to the completion of embryo turning (Mus: E9-9.5)" [https://orcid.org/0000-0003-4606-0597]
synonym: "complete embryonic lethality prior to organogenesis" EXACT []
is_a: MP:0013292 ! embryonic lethality prior to organogenesis
is_a: MP:0014257 ! embryonic lethality prior to tooth bud stage, complete penetrance
property_value: dc:date "2023-06-20T18:10:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014260
name: embryonic lethality prior to organogenesis, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms prior to the completion of embryo turning (Mus: E9-9.5)" [https://orcid.org/0000-0003-4606-0597]
synonym: "incomplete embryonic lethality prior to organogenesis" EXACT []
synonym: "partial embryonic lethality prior to organogenesis" EXACT []
is_a: MP:0013292 ! embryonic lethality prior to organogenesis
is_a: MP:0014258 ! embryonic lethality prior to tooth bud stage, incomplete penetrance
property_value: dc:date "2023-06-20T18:10:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014261
name: abnormal spleen B cell follicle number
def: "any anomaly in the number of areas of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal spleen B lymphocyte follicle number" EXACT []
synonym: "abnormal splenic B cell follicle number" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology
property_value: dc:date "2023-06-20T18:31:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014262
name: increased spleen B cell follicle number
def: "increase in the number of areas of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated spleen B lymphocyte follicle number" EXACT []
synonym: "increased splenic B cell follicle number" EXACT []
is_a: MP:0014261 ! abnormal spleen B cell follicle number
property_value: dc:date "2023-06-20T18:31:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014263
name: decreased spleen B cell follicle number
def: "reduction in the number of areas of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased splenic B cell follicle number" EXACT []
synonym: "reduced spleen B lymphocyte follicle number" EXACT []
is_a: MP:0014261 ! abnormal spleen B cell follicle number
property_value: dc:date "2023-06-20T18:32:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014264
name: abnormal perivascular vein cell coverage
def: "any anomaly in the extent to which the cells residing around veins surround the vessel, these cells include vascular smooth muscle cells and pericytes" [https://doi.org/10.1161/JAHA.118.010690]
synonym: "abnormal PVC coverage" EXACT []
is_a: MP:0002725 ! abnormal vein morphology
property_value: dc:date "2023-06-20T19:00:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014265
name: thick retina inner plexiform layer
def: "increased thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retina inner plexiform layer thickness" EXACT []
synonym: "increased retinal inner plexiform layer thickness" EXACT []
synonym: "thick retinal IPL" EXACT []
is_a: MP:0003734 ! abnormal retina inner plexiform layer morphology
property_value: dc:date "2023-06-20T20:00:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014266
name: thick retina outer plexiform layer
def: "increased thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retina OPL thickness" EXACT []
synonym: "thick retinal OPL" EXACT []
is_a: MP:0003732 ! abnormal retina outer plexiform layer morphology
property_value: dc:date "2023-06-20T20:05:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014267
name: decreased sex gland secretion
def: "a reduction in the production and/or release of hormones from a cell or a gland of the reproductive system" [https://www.mayoclinic.org/diseases-conditions/male-hypogonadism/symptoms-causes/syc-20354881] {comment="https://medlineplus.gov/ency/article/001195.htm"}
synonym: "hypogonadism" EXACT []
synonym: "reduced sex gland secretion" EXACT []
is_a: MP:0002779 ! abnormal sex gland secretion
property_value: dc:date "2023-07-21T18:54:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014268
name: increased sex gland secretion
def: "an increase in the production and/or release of hormones from a cell or a gland of the reproductive system" [https://www.healthline.com/health/hypergonadism]
synonym: "enhanced sex gland secretion" EXACT []
synonym: "hypergonadism" EXACT []
is_a: MP:0002779 ! abnormal sex gland secretion
property_value: dc:date "2023-07-21T19:10:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014269
name: decreased testes secretion
def: "reduction in the production and/or release of hormones from testicular tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "male hypogonadism" EXACT []
synonym: "reduced testis secretion" EXACT []
is_a: MP:0002782 ! abnormal testes secretion
is_a: MP:0014267 ! decreased sex gland secretion
property_value: dc:date "2023-07-21T19:37:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014270
name: decreased ovary secretion
def: "reduction in the production and/or release of hormones from ovarian tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "female hypogonadism" EXACT []
synonym: "reduced ovarian secretion" EXACT []
is_a: MP:0002783 ! abnormal ovary secretion
is_a: MP:0014267 ! decreased sex gland secretion
property_value: dc:date "2023-07-21T19:37:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014271
name: increased testes secretion
def: "elevation in the production and/or release of hormones from testicular tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated testis secretion" EXACT []
synonym: "male hypergonadism" EXACT []
is_a: MP:0002782 ! abnormal testes secretion
is_a: MP:0014268 ! increased sex gland secretion
property_value: dc:date "2023-07-21T19:37:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014272
name: increased ovary secretion
def: "elevation in the production and/or release of hormones from ovarian tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated ovarian secretion" EXACT []
synonym: "enhanced ovarian secretion" EXACT []
synonym: "female hypergonadism" EXACT []
is_a: MP:0002783 ! abnormal ovary secretion
is_a: MP:0014268 ! increased sex gland secretion
property_value: dc:date "2023-07-21T19:38:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014273
name: abnormal skin vasculature morphology
def: "any structural anomaly of the network of tubes that carries blood through the skin" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal skin blood vessel morphology" EXACT []
synonym: "vascular skin abnormality" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0002060 ! abnormal skin morphology
property_value: dc:date "2023-07-21T20:13:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014274
name: decreased respiration
def: "decrease in the movement of gases into and out of the lung" [https://orcid.org/0000-0003-4606-0597]
synonym: "impaired respiration" EXACT []
synonym: "reduced respiration" EXACT []
is_a: MP:0001943 ! abnormal respiration
property_value: dc:date "2023-07-21T20:43:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014275
name: increased respiration
def: "increase in the movement of gases into and out of the lung" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced respiration" EXACT []
is_a: MP:0001943 ! abnormal respiration
property_value: dc:date "2023-07-21T20:43:31Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014276
name: lobar holoprosencephaly
def: "the least severe form of holosprosencephaly, most of the brain is separated into two hemispheres but the division is incomplete with the cerebral hemispheres fused in the frontal cortex" [https://my.clevelandclinic.org/health/diseases/22919-holoprosencephaly-hpe]
synonym: "lobar HPE" EXACT []
is_a: MP:0005157 ! holoprosencephaly
property_value: dc:date "2023-07-25T15:37:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014277
name: alobar holoprosencephaly
def: "the most severe forme of holoprosencaphaly with complete failure of the brain to separate into two hemispheres" [] {comment="https://my.clevelandclinic.org/health/diseases/22919-holoprosencephaly-hpe"}
synonym: "alobar HPE" EXACT []
is_a: MP:0005157 ! holoprosencephaly
property_value: dc:date "2023-07-25T15:41:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014278
name: semilobar holoprosencephaly
def: "a type of holoprosencephaly with partial division of the brain into two hemispheres, fusion of the hemispheres is present in the frontal and parietal lobes with the interhemispheric fissure present only in the back of the brain" [https://my.clevelandclinic.org/health/diseases/22919-holoprosencephaly-hpe]
synonym: "semilobar HPE" EXACT []
is_a: MP:0005157 ! holoprosencephaly
property_value: dc:date "2023-07-25T16:04:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014279
name: abnormal intestinal rotation
def: "any anomaly in the normal turning and fixation of the intestine during development potentially resulting in twisting of the intestine" [https://kidshealth.org/en/parents/malrotation.html, https://www.cincinnatichildrens.org/health/i/intestinal-malrotation]
synonym: "intestinal malrotation" EXACT []
is_a: MP:0014023 ! abnormal intestine placement
property_value: dc:date "2023-07-25T18:24:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014280
name: forelimb oligodactyly
def: "congenital condition in which some digits or parts of digits are missing from the autopods of the forelimbs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000565 ! oligodactyly
property_value: dc:date "2023-07-25T18:54:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014281
name: hindlimb oligodactyly
def: "congenital condition in which some digits or parts of digits are missing from the autopods of the hindlimbs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000565 ! oligodactyly
property_value: dc:date "2023-07-25T18:54:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014282
name: forelimb syndactyly
def: "any degree of webbing or fusion of the digits of the forelimb autopod, may involve only soft tissues or also can include bone" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000564 ! syndactyly
property_value: dc:date "2023-07-25T19:03:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014283
name: hindlimb syndactyly
def: "any degree of webbing or fusion of the digits of the hindlimb autopod, may involve only soft tissues or also can include bone" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000564 ! syndactyly
property_value: dc:date "2023-07-25T19:04:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014284
name: abnormal adrenal gland zona fasciculata size
def: "anomaly in the size of the wide middle zone of the adrenal cortex that produces cortisol" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008294 ! abnormal adrenal gland zona fasciculata morphology
property_value: dc:date "2023-08-08T14:51:31Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014285
name: disorganized adrenal gland zona fasciculata
def: "derangement of the pattern of the cells in the wide middle zone of the adrenal cortex" [https://orcid.org/0000-0003-4606-0597]
synonym: "disorganised adrenal gland zona fasciculata" EXACT []
is_a: MP:0008294 ! abnormal adrenal gland zona fasciculata morphology
property_value: dc:date "2023-08-08T14:52:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014286
name: increased adrenal gland zona fasciculata size
def: "increase in the size of the wide middle zone of the adrenal cortex that produces cortisol" [https://orcid.org/0000-0001-5356-4174]
synonym: "enlarged adrenal gland zona fasciculata area" EXACT []
synonym: "expanded adrenal gland zona fasciculata" EXACT []
is_a: MP:0014284 ! abnormal adrenal gland zona fasciculata size
property_value: dc:date "2023-08-08T14:53:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014287
name: decreased adrenal gland zona fasciculata size
def: "decrease in the size of the wide middle zone of the adrenal cortex that produces cortisol" [https://orcid.org/0000-0001-5356-4174]
synonym: "reduced adrenal gland zona fasciculata size" EXACT []
is_a: MP:0014284 ! abnormal adrenal gland zona fasciculata size
property_value: dc:date "2023-08-08T14:53:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014288
name: rhizomelic limb
def: "the proximal portion of the limbs are dispropotionately shortened" [http://purl.obolibrary.org/obo/HP_0008905, https://link.springer.com/chapter/10.1007/978-3-642-54610-5_13]
synonym: "decreased proximal limb length" EXACT []
synonym: "rhizomelia" RELATED []
synonym: "short proximal limb" EXACT []
is_a: MP:0000547 ! short limbs
property_value: dc:date "2023-08-08T19:27:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014289
name: decreased distal limb length
def: "the distal portion of the limbs are dispropotionately shortened" [http://purl.obolibrary.org/obo/HP_0006402]
synonym: "reduced distal imb length" EXACT []
synonym: "short distal limb" EXACT []
is_a: MP:0000547 ! short limbs
property_value: dc:date "2023-08-08T19:35:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014290
name: abnormal autopod size
def: "anomaly in the size of the distal elements of the limb" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000572 ! abnormal autopod morphology
property_value: dc:date "2023-08-08T20:08:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014291
name: decreased autopod size
def: "reduced size of the distal elements of the limb of vertebrates" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced autopod size" EXACT []
synonym: "small autopod" EXACT []
synonym: "truncated autopod" NARROW []
is_a: MP:0014290 ! abnormal autopod size
property_value: dc:date "2023-08-08T20:20:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014292
name: decreased internal diameter of tibia
def: "reduced cross-sectional distance that extends from one lateral edge of the tibia long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the tibia" [https://orcid.org/0000-0001-5356-4174, PMID:35239186]
synonym: "decreased endosteal diameter of tibia" EXACT []
synonym: "decreased inner diameter of tibia" EXACT []
synonym: "decreased tibia medullary cavity diameter" EXACT []
synonym: "reduced tibia bone marrow cavity diameter" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0013619 ! abnormal long bone internal diameter
property_value: dc:date "2023-08-09T19:40:36Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014293
name: increased internal diameter of tibia
def: "increased cross-sectional distance that extends from one lateral edge of the tibia long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the tibia" [https://orcid.org/0000-0001-5356-4174, PMID:35239186]
synonym: "increased endosteal diameter of tibia" EXACT []
synonym: "increased inner diameter of tibia" EXACT []
synonym: "increased tibia bone marrow cavity diameter" EXACT []
synonym: "increased tibia medullary cavity diameter" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0013619 ! abnormal long bone internal diameter
property_value: dc:date "2023-08-09T19:40:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014294
name: abnormal skeletal maturation
def: "any anomaly in the series of characteristic changes in size, shape, and calcification occuring in the skeleton from fetal life until puberty that result in the skeleton reaching its full maturity" [HP:0000927, https://www.sciencedirect.com/topics/medicine-and-dentistry/bone-maturation]
is_a: MP:0002113 ! abnormal skeleton development
property_value: dc:date "2023-08-09T20:09:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014295
name: premature skeletal maturation
def: "earlier than expected age at which the skeleton reaches specific stages of maturation" [https://orcid.org/0000-0003-4606-0597]
synonym: "early skeletal maturation" EXACT []
is_a: MP:0014294 ! abnormal skeletal maturation
property_value: dc:date "2023-08-09T20:26:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014296
name: delayed skeletal maturation
def: "later than expected age at which the skeleton reaches specific stages of maturation" [https://orcid.org/0000-0003-4606-0597]
synonym: "late skeletal maturation" EXACT []
is_a: MP:0014294 ! abnormal skeletal maturation
property_value: dc:date "2023-08-09T20:26:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014297
name: abnormal cochlea size
def: "anomaly in the size of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cochlear size" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology
property_value: dc:date "2023-08-25T17:34:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014298
name: abnormal cochlear width
def: "any anomaly in the side to side dimension of the cochlea" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014297 ! abnormal cochlea size
property_value: dc:date "2023-08-25T17:45:15Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014299
name: increased cochlea size
def: "increased size of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "large cochlea" EXACT []
is_a: MP:0014297 ! abnormal cochlea size
property_value: dc:date "2023-08-25T17:45:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014300
name: decreased cochlea size
def: "reduced size of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "small cochlea" EXACT []
is_a: MP:0014297 ! abnormal cochlea size
property_value: dc:date "2023-08-25T17:45:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014301
name: decreased cochlea width
def: "reduction in the side to side dimension of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "narrow cochlea" EXACT []
is_a: MP:0014298 ! abnormal cochlear width
property_value: dc:date "2023-08-25T17:46:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014302
name: increased cochlea width
def: "increase in the side to side dimension of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "wide cochlea" EXACT []
is_a: MP:0014298 ! abnormal cochlear width
property_value: dc:date "2023-08-25T17:46:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014303
name: abnormal cochlea length
def: "any anomaly in the end to end length of the cochlea" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014297 ! abnormal cochlea size
property_value: dc:date "2023-08-25T17:47:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014304
name: increased cochlea length
def: "increase in the end to end length of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "long cochlea" EXACT []
is_a: MP:0014303 ! abnormal cochlea length
property_value: dc:date "2023-08-25T17:47:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014305
name: decreased cochlea length
def: "decrease in the end to end length of the cochlea" [https://orcid.org/0000-0003-4606-0597]
synonym: "short cochlea" EXACT []
is_a: MP:0014303 ! abnormal cochlea length
property_value: dc:date "2023-08-25T17:47:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014306
name: increased cochlea coiling
def: "an increase in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased cochlear coiling" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology
property_value: dc:date "2023-08-25T19:26:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014307
name: decreased femor compact bone volume
def: "less than normal amount of space occupied by compact bone tissue in the femor" [https://orcid.org/0000-0003-4606-0597, PMID:35239186]
synonym: "reduced femor compact bone volume" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0010965 ! decreased compact bone volume
property_value: dc:date "2023-08-25T19:46:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014308
name: decreased tibia compact bone volume
def: "less than normal amount of space occupied by compact bone tissue in the tibia" [https://orcid.org/0000-0003-4606-0597, PMID:35239186]
synonym: "decreased tibia cortical bone volume" EXACT []
synonym: "reduced tibial compact bone volume" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0010965 ! decreased compact bone volume
property_value: dc:date "2023-08-25T19:46:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014309
name: increased femor compact bone volume
def: "greater than normal amount of space occupied by compact bone tissue in the femor" [https://orcid.org/0000-0003-4606-0597, PMID:35239186]
synonym: "increased femoral compact bone volume" EXACT []
synonym: "increased femur cortical bone volume" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0010964 ! increased compact bone volume
property_value: dc:date "2023-08-25T19:47:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014310
name: increased tibia compact bone volume
def: "greater than normal amount of space occupied by compact bone tissue in the tibia" [https://orcid.org/0000-0003-4606-0597, PMID:35239186]
synonym: "increased tibia cortical bone volume" EXACT []
synonym: "increased tibial compact bone volume" EXACT []
is_a: MP:0000558 ! abnormal tibia morphology
is_a: MP:0010964 ! increased compact bone volume
property_value: dc:date "2023-08-25T19:47:41Z" xsd:dateTime
property_value: oboInOwl:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014311
name: increased primordial germ cell proliferation
def: "increase in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated PGC proliferation" EXACT []
is_a: MP:0008390 ! abnormal primordial germ cell proliferation
property_value: dc:date "2023-08-29T19:35:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014312
name: thick lower lip
def: "lower lip has an abundance and often an excess of soft tissue" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick bottom lip" EXACT []
synonym: "thick lower lip vermilion" EXACT []
is_a: MP:0003774 ! thick lip
is_a: MP:0012524 ! abnormal lower lip morphology
property_value: dc:date "2023-10-17T20:02:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014313
name: thin lower lip
def: "lower lip has a reduced amount of soft tissue" [] {def="https://orcid.org/0000-0003-4606-0597"}
synonym: "thin bottom lip" EXACT []
synonym: "thin lower lip vermilion" EXACT []
is_a: MP:0003775 ! thin lip
is_a: MP:0012524 ! abnormal lower lip morphology
property_value: dc:date "2023-10-17T20:06:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014314
name: irregular cerebellar foliation pattern
def: "derangement of the normal organized pattern of the folia into one lacking uniformity" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000857 ! abnormal cerebellar foliation
property_value: dc:date "2023-10-17T20:41:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014315
name: decreased heart left ventricle anterior wall thickness
def: "decrease in the depth of the cardiac wall on the anterior side of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced heart left ventricle anterior wall thickness" EXACT []
synonym: "thin left ventricular anterior wall" EXACT []
is_a: MP:0021158 ! decreased heart left ventricle wall thickness
property_value: dc:date "2023-10-18T18:15:31Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014316
name: decreased heart left ventricle posterior wall thickness
def: "decrease in the depth of the cardiac wall on the posterior side of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced heart left ventricle posterior wall thickness" EXACT []
synonym: "thin cardiac left ventricular posterior wall" EXACT []
is_a: MP:0021158 ! decreased heart left ventricle wall thickness
property_value: dc:date "2023-10-18T18:15:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014317
name: decreased heart left ventricle septal wall thickness
def: "decrease in the depth of the cardiac septal wall of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced heart left ventricle septal wall thickness" EXACT []
synonym: "thin cardiac left ventricular septal wall" EXACT []
is_a: MP:0010725 ! thin interventricular septum
is_a: MP:0021158 ! decreased heart left ventricle wall thickness
property_value: dc:date "2023-10-18T18:16:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014318
name: abnormal oligodendrocyte differentiation
def: "anomaly in the process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte" [http://purl.obolibrary.org/obo/GO_0048709, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal oligodendroglia differentiation" EXACT []
synonym: "abnormal oligodendroglial cell differentiation" EXACT []
synonym: "abnormal oligoglia differentiation" EXACT []
synonym: "abnormal oligoglial cell differentiation" EXACT []
is_a: MP:0008917 ! abnormal oligodendrocyte physiology
property_value: dc:date "2023-10-18T18:45:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014319
name: abnormal heart atrium arrangement
def: "any anomaly in the spatial relationship of the atria to other compartments of the heart" [] {def="HP:0011535"}
synonym: "abnormal atrial arrangement" EXACT []
synonym: "abnormal location of heart atrium" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: dc:date "2023-11-13T21:56:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014320
name: abnormal autopod rotation
def: "any anomaly in the rotational alignment of the autopods relative to the limbs" [https://en.wikipedia.org/wiki/Bone_malrotation, https://orcid.org/0000-0003-4606-0597, PMID:2320577]
synonym: "abnormal autopod orientation" EXACT []
synonym: "autopod malrotation" NARROW []
is_a: MP:0000572 ! abnormal autopod morphology
property_value: dc:date "2023-11-14T20:47:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014321
name: short forelimb
def: "reduced average length of the forelimbs" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased forelimb length" EXACT []
synonym: "reduced forelimb length" EXACT []
synonym: "short forelimbs" EXACT []
is_a: MP:0000547 ! short limbs
is_a: MP:0000550 ! abnormal forelimb morphology
property_value: dc:date "2023-11-14T21:07:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014322
name: short hindlimb
def: "reduced average length of the hindlimbs" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased hindlimb length" EXACT []
synonym: "reduced hindlimb length" EXACT []
synonym: "short hindlimbs" EXACT []
is_a: MP:0000547 ! short limbs
is_a: MP:0000556 ! abnormal hindlimb morphology
property_value: dc:date "2023-11-14T21:07:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014323
name: long hindlimb
def: "increased average length of the hindlimbs" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased hindlimb length" EXACT []
synonym: "long hindlimbs" EXACT []
is_a: MP:0000548 ! long limbs
is_a: MP:0000556 ! abnormal hindlimb morphology
property_value: dc:date "2023-11-14T21:12:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014324
name: long forelimb
def: "increased average length of the forelimbs" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased forelimb length" EXACT []
synonym: "long forelimbs" EXACT []
is_a: MP:0000548 ! long limbs
is_a: MP:0000550 ! abnormal forelimb morphology
property_value: dc:date "2023-11-14T21:12:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014325
name: abnormal oligodendrocyte progenitor morphology
def: "any structural anomaly in the cells that differentiate into oligodendrocytes or type-2 astrocytes in the central nervous system" [CL:0002453]
synonym: "abnormal oligodendrocyte precursor cell morphology" EXACT []
is_a: MP:0000358 ! abnormal cell morphology
is_a: MP:0000913 ! abnormal brain development
property_value: dc:date "2023-11-14T21:39:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014326
name: abnormal Purkinje cell size
def: "any anomaly in the size of the inhibitory neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000877 ! abnormal Purkinje cell morphology
property_value: dc:date "2023-12-07T16:08:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014327
name: decreased Purkinje cell size
def: "decrease in the size of Purkinje cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced Purkinje cell size" EXACT []
synonym: "small Purkinje cells" EXACT []
is_a: MP:0014326 ! abnormal Purkinje cell size
property_value: dc:date "2023-12-07T16:08:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014328
name: increased Purkinje cell size
def: "increase in the size of Purkinje cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged Purkinje cells" EXACT []
synonym: "Purkinje cell hypertrophy" EXACT []
is_a: MP:0005603 ! neuron hypertrophy
is_a: MP:0014326 ! abnormal Purkinje cell size
property_value: dc:date "2023-12-07T16:09:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014329
name: abnormal Purkinje cell axon morphology
def: "any structural anomaly of the single process of a Purkinje cell that normally conducts impulses away from the cell body" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal Purkinje cell axonal morphology" EXACT []
synonym: "abnormal Purkinje nerve fiber morphology" EXACT []
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0005404 ! abnormal axon morphology
property_value: dc:date "2023-12-08T18:11:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014330
name: abnormal Purkinje cell focal axonal swelling
def: "any anomaly in localized enlargements of the axon of a Purkinje cell" [PMID:27853421, PMID:3510690]
synonym: "abnormal Purkinje cell axonal torpedoes" EXACT []
is_a: MP:0014329 ! abnormal Purkinje cell axon morphology
property_value: dc:date "2023-12-08T18:14:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014331
name: abnormal Purkinje cell mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in the Purkinje cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal Purkinje neuron mitochondrial morphology" EXACT []
synonym: "abnormal Purkinje neuron mitochondrion morphology" EXACT []
is_a: MP:0000877 ! abnormal Purkinje cell morphology
is_a: MP:0014345 ! abnormal neuron mitochondrial morphology
property_value: dc:date "2023-12-08T19:17:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014332
name: long retina cone cell outer segment
def: "increased length of the retinal cone cell outer segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal cone cell outer segment length" EXACT []
synonym: "long COS" EXACT []
is_a: MP:0008449 ! abnormal retina cone cell outer segment morphology
is_a: MP:0020812 ! long photoreceptor outer segment
property_value: dc:date "2023-12-08T20:02:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014333
name: short retina cone cell outer segment
def: "decreased length of the retinal cone cell outer segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal cone cell photoreceptor outer segment length" EXACT []
synonym: "reduced retinal cone cell photoreceptor outer segment length" EXACT []
synonym: "short COS" EXACT []
is_a: MP:0008449 ! abnormal retina cone cell outer segment morphology
is_a: MP:0008587 ! short photoreceptor outer segment
property_value: dc:date "2023-12-08T20:03:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014334
name: short retina cone cell inner segment
def: "decreased length of the retinal cone cell inner segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal cone cell photoreceptor inner segment length" EXACT []
synonym: "reduced retinal cone cell photoreceptor inner segment length" EXACT []
is_a: MP:0008448 ! abnormal retina cone cell inner segment morphology
is_a: MP:0008582 ! short photoreceptor inner segment
property_value: dc:date "2023-12-08T20:10:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014335
name: long retina cone cell inner segment
def: "increased length of the retinal cone cell inner segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal cone cell photoreceptor inner segment length" EXACT []
is_a: MP:0008448 ! abnormal retina cone cell inner segment morphology
is_a: MP:0014247 ! long photoreceptor inner segment
property_value: dc:date "2023-12-08T20:10:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014336
name: short retina rod cell outer segment
def: "decreased length of the retinal rod cell outer segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal rod cell outer segment length" EXACT []
synonym: "reduced retinal rod cell outer segment length" EXACT []
is_a: MP:0008456 ! abnormal retina rod cell outer segment morphology
is_a: MP:0008587 ! short photoreceptor outer segment
property_value: dc:date "2023-12-08T20:20:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014337
name: long retina rod cell outer segment
def: "increased length of the retinal rod cell outer segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal rod cell outer segment length" EXACT []
is_a: MP:0008456 ! abnormal retina rod cell outer segment morphology
is_a: MP:0020812 ! long photoreceptor outer segment
property_value: dc:date "2023-12-08T20:20:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014338
name: abnormal spleen B cell follicle size
def: "deviation from the normal size of the B cell follicles in the spleen" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal spleen B lymphocyte follicle size" EXACT []
synonym: "abnormal splenic B cell follicle size" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology
property_value: dc:date "2023-12-15T19:18:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014339
name: long retina rod cell inner segment
def: "increased length of the retinal rod cell inner segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retinal rod cell inner segment length" EXACT []
is_a: MP:0008455 ! abnormal retina rod cell inner segment morphology
is_a: MP:0014247 ! long photoreceptor inner segment
property_value: dc:date "2023-12-08T20:31:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014340
name: short retina rod cell inner segment
def: "decreased length of the retinal rod cell inner segment" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased retinal rod cell inner segment length" EXACT []
synonym: "reduced retinal rod cell inner segment length" EXACT []
is_a: MP:0008455 ! abnormal retina rod cell inner segment morphology
is_a: MP:0008582 ! short photoreceptor inner segment
property_value: dc:date "2023-12-08T20:32:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014341
name: abnormal hepatocyte mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in the hepatocytes" [] {comment="https://orcid.org/0000-0003-4606-0597"}
synonym: "abnormal hepatocyte mitochondria morphology" EXACT []
synonym: "abnormal hepatocyte mitochondrion morphology" EXACT []
is_a: MP:0000607 ! abnormal hepatocyte morphology
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: dc:date "2023-12-08T21:07:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014342
name: abnormal muscle fiber mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in muscle fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal muscle fiber mitochondrion morphology" EXACT []
synonym: "abnormal muscle fibre mitochondria morphology" EXACT []
is_a: MP:0004087 ! abnormal muscle fiber morphology
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: dc:date "2023-12-08T21:11:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014343
name: abnormal myocardial fiber mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in myocardial fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal adult cardiomyocyte mitochondria morphology" EXACT []
synonym: "abnormal adult cardiomyocyte mitochondrial morphology" EXACT []
synonym: "abnormal cardiac muscle cell mitochondrion morphology" EXACT []
synonym: "abnormal myocardial cell mitochondrial morphology" EXACT []
synonym: "abnormal myocardial fibre mitochondrial morphology" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology
is_a: MP:0014342 ! abnormal muscle fiber mitochondrial morphology
property_value: dc:date "2023-12-08T21:15:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014344
name: abnormal skeletal muscle fiber mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in skeletal muscle fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal skeletal muscle fiber mitochondrion morphology" EXACT []
synonym: "abnormal skeletal muscle fibre mitochondria morphology" EXACT []
is_a: MP:0003084 ! abnormal skeletal muscle fiber morphology
is_a: MP:0014342 ! abnormal muscle fiber mitochondrial morphology
property_value: dc:date "2023-12-08T21:20:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014345
name: abnormal neuron mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in neurons" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal neuron mitochondria morphology" EXACT []
synonym: "abnormal neuron mitochondrion morphology" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology
is_a: MP:0006035 ! abnormal mitochondrial morphology
property_value: dc:date "2023-12-08T21:26:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014346
name: abnormal motor neuron mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in motor neurons" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal motoneuron mitochondria morphology" EXACT []
synonym: "abnormal motor neuron mitochondrion morphology" EXACT []
is_a: MP:0000937 ! abnormal motor neuron morphology
is_a: MP:0014345 ! abnormal neuron mitochondrial morphology
property_value: dc:date "2023-12-08T21:30:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014347
name: increased spleen B cell follicle size
def: "larger than normal size of the B cell follicles in the spleen" [] {def="https://orcid.org/0000-0003-4606-0597"}
synonym: "enlarged spleen B lymphocyte follicles" EXACT []
synonym: "increased splenic B cell follicle size" EXACT []
is_a: MP:0014338 ! abnormal spleen B cell follicle size
property_value: dc:date "2023-12-15T19:23:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014348
name: decreased spleen B cell follicle size
def: "smaller than normal size of the B cell follicles in the spleen" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced splenic B cell follicle size" EXACT []
synonym: "small spleen B lymphocyte follicles" EXACT []
is_a: MP:0014338 ! abnormal spleen B cell follicle size
property_value: dc:date "2023-12-15T19:24:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014349
name: absent spleen B cell follicles
def: "absence of all the B cell follicles in the spleen" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent spleen B lymphocyte follicles" EXACT []
synonym: "absent splenic B cell follicles" EXACT []
is_a: MP:0014263 ! decreased spleen B cell follicle number
property_value: dc:date "2023-12-15T19:35:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014350
name: disorganized spleen B cell follicle
def: "derangement of the normal pattern of B cells within the follicles of the spleen" [https://orcid.org/0000-0003-4606-0597, PMID:9697836]
synonym: "disorganized spleen B lymphocyte follicles" EXACT []
synonym: "splenic B cell follicle disorganization" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology
property_value: dc:date "2023-12-15T19:42:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014351
name: abnormal spleen B cell follicle shape
def: "any anomaly in the characteristic surface outline or contour of the B cell follicles in the spleen" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal spleen B lymphocyte follicle shape" EXACT []
synonym: "abnormal splenic B cell follicle shape" EXACT []
is_a: MP:0008470 ! abnormal spleen B cell follicle morphology
property_value: dc:date "2023-12-15T19:53:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014352
name: abnormal brush cell morphology
def: "any structural anomaly in cells characterized by a tuft of blunt, squat microvilli found in the gastrointestinal and respiratory tracts" [http://purl.obolibrary.org/obo/CL_0002204]
synonym: "abnomral tuft cell morphology" EXACT []
synonym: "abnormal caveolated cell morphology" EXACT []
synonym: "abnormal fibrillovesicular cell morphology" EXACT []
synonym: "abnormal multivesicular cell morphology" EXACT []
is_a: MP:0000358 ! abnormal cell morphology
property_value: dc:date "2023-12-15T20:49:04Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014353
name: abnormal gastrointestinal brush cell morphology
def: "any structural anomaly in cells characterized by a tuft of blunt, squat microvilli typically found in the gastrointestinal tract" [http://purl.obolibrary.org/obo/CL_0002204, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal digestive tract fibrillovesicular cell morphology" EXACT []
synonym: "abnormal digestive tract multivesicular cell morphology" EXACT []
synonym: "abnormal digestive tract tuft cell morphology" EXACT []
synonym: "abnormal gastrointestinal tract caveolated cell morphology" EXACT []
is_a: MP:0000462 ! abnormal digestive system morphology
is_a: MP:0014352 ! abnormal brush cell morphology
property_value: dc:date "2023-12-15T20:54:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014354
name: abnormal respiratory tract brush cell morphology
def: "any structural anomaly in cells characterized by a tuft of blunt, squat microvilli typically found in the respiratory tract" [http://purl.obolibrary.org/obo/CL_0002204, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal respiratory tract caveolated cell morphology" EXACT []
synonym: "abnormal respiratory tract fibrillovesicular cell morphology" EXACT []
synonym: "abnormal respiratory tract multivesicular cell morphology" EXACT []
synonym: "abnormal respiratory tract tuft cell morphology" EXACT []
is_a: MP:0002132 ! abnormal respiratory system morphology
is_a: MP:0014352 ! abnormal brush cell morphology
property_value: dc:date "2023-12-15T20:55:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014355
name: abnormal programmed cell death
def: "any anomaly in a process which begins when a cell receives an internal or external signal and activates a series of biochemical eventsthat ends with the death of the cell" [http://purl.obolibrary.org/obo/GO_0012501]
synonym: "abnormal PCD" EXACT []
synonym: "abnormal regulated cell death" EXACT []
is_a: MP:0000313 ! abnormal cell death
property_value: dc:date "2024-02-02T21:20:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014356
name: abnormal necroptotic process
def: "any anomaly in the process which begins when a cell receives a signal and proceeds through a series of biochemical events, characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death" [GO:0070266]
synonym: "abnormal necroptosis" EXACT []
is_a: MP:0014355 ! abnormal programmed cell death
property_value: dc:date "2024-02-02T21:36:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014357
name: abnormal pyroptosis
def: "any anomaly in the caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18" [GO:0070269]
is_a: MP:0014355 ! abnormal programmed cell death
property_value: dc:date "2024-02-02T21:47:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014358
name: abnormal ferroptosis
def: "any anomaly in the process characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture" [GO:0097707]
synonym: "abnormal iron-dependent programmed cell death" EXACT []
is_a: MP:0014355 ! abnormal programmed cell death
property_value: dc:date "2024-02-02T21:50:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014359
name: increased ferroptosis
def: "more than the expected amount or rate of ferroptosis in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated iron-dependent programmed cell death" EXACT []
is_a: MP:0014358 ! abnormal ferroptosis
property_value: dc:date "2024-02-05T20:18:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014360
name: decreased ferroptosis
def: "less than the expected amount or rate of ferroptosis in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced iron-dependent programmed cell death" EXACT []
is_a: MP:0014358 ! abnormal ferroptosis
property_value: dc:date "2024-02-05T20:18:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014361
name: increased necroptotic process
def: "more than the expected amount or rate of necroptotic processes in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated necroptosis" EXACT []
is_a: MP:0014356 ! abnormal necroptotic process
property_value: dc:date "2024-02-05T20:24:36Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014362
name: decreased necroptotic process
def: "less than the expected amount or rate of necroptotic processes in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced necroptosis" EXACT []
is_a: MP:0014356 ! abnormal necroptotic process
property_value: dc:date "2024-02-05T20:24:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014363
name: increased pyroptosis
def: "more than the expected amount or rate of pyroptosis in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated pyroptosis" EXACT []
is_a: MP:0014357 ! abnormal pyroptosis
property_value: dc:date "2024-02-05T20:29:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014364
name: decreased pyroptosis
def: "less than the expected amount or rate of pyroptosis in the whole organism, tissue, or cell population" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced pyroptosis" EXACT []
is_a: MP:0014357 ! abnormal pyroptosis
property_value: dc:date "2024-02-05T20:29:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0014365
name: impaired short-term object recognition memory
def: "impaired ability of short-term memory to recognize objects during the first few minutes after training" [PMID:38378836]
synonym: "decreased short-term recognition memory" EXACT []
synonym: "short-term recognition memory deficit" EXACT []
is_a: MP:0002800 ! abnormal short-term object recognition memory
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-05T22:05:21Z" xsd:dateTime

[Term]
id: MP:0014366
name: enhanced short-term object recognition memory
def: "enhanced ability of short-term memory to recognize objects during the first few minutes after training" [PMID:38378836]
synonym: "increased short-term recognition memory" EXACT []
is_a: MP:0002800 ! abnormal short-term object recognition memory
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-05T22:05:33Z" xsd:dateTime

[Term]
id: MP:0014367
name: impaired long-term object recognition memory
def: "impairment of the long-term memory for objects that is consolidated over hours and days after training" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased long-term recognition memory" EXACT []
synonym: "long-term recognition memory deficit" EXACT []
is_a: MP:0002801 ! abnormal long-term object recognition memory
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-05T22:05:51Z" xsd:dateTime

[Term]
id: MP:0014368
name: enhanced long-term object recognition memory
def: "enhancement of the long-term memory for objects that is consolidated over hours and days after training" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased long-term recognition memory" EXACT []
is_a: MP:0002801 ! abnormal long-term object recognition memory
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-05T22:06:07Z" xsd:dateTime

[Term]
id: MP:0014369
name: enhanced spatial working memory
def: "enhamced ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased spatial working memory" EXACT []
is_a: MP:0008428 ! abnormal spatial working memory
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T16:05:15Z" xsd:dateTime

[Term]
id: MP:0014370
name: impaired spatial working memory
def: "impaired ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased spatial working memory" EXACT []
synonym: "reduced spatial working memory" EXACT []
synonym: "spatial working memory deficit" EXACT []
is_a: MP:0008428 ! abnormal spatial working memory
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T16:05:31Z" xsd:dateTime

[Term]
id: MP:0014371
name: abnormal miniature excitatory postsynaptic current amplitude
def: "anomaly in the size (height or maximum displacement) or shape of the miniature excitatory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mEPSC amplitude" EXACT []
synonym: "abnormal miniature excitatory post-synaptic current amplitude" EXACT []
is_a: MP:0004753 ! abnormal miniature excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:41:55Z" xsd:dateTime

[Term]
id: MP:0014372
name: decreased miniature excitatory postsynaptic current amplitude
def: "decrease in the size (height or maximum displacement) of the miniature excitatory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced mEPSC amplitude" EXACT []
synonym: "reduced miniature excitatory post-synaptic current amplitude" EXACT []
is_a: MP:0014371 ! abnormal miniature excitatory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:45:06Z" xsd:dateTime

[Term]
id: MP:0014373
name: increased miniature excitatory postsynaptic current amplitude
def: "increase in the size (height or maximum displacement) of the miniature excitatory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated miniature excitatory post-synaptic current amplitude" EXACT []
synonym: "increased mEPSC amplitude" EXACT []
is_a: MP:0014371 ! abnormal miniature excitatory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:45:17Z" xsd:dateTime

[Term]
id: MP:0014374
name: abnormal miniature excitatory postsynaptic current frequency
def: "any anomaly in the number of occurrences of miniature excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mEPSC frequency" EXACT []
synonym: "abnormal miniature excitatory post-synaptic current frequency" EXACT []
is_a: MP:0004753 ! abnormal miniature excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:50:56Z" xsd:dateTime

[Term]
id: MP:0014375
name: increased miniature excitatory postsynaptic current frequency
def: "increase in the number of occurrences of miniature excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated miniature excitatory post-synaptic current frequency" EXACT []
synonym: "increased mEPSC frequency" EXACT []
is_a: MP:0014374 ! abnormal miniature excitatory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:51:05Z" xsd:dateTime

[Term]
id: MP:0014376
name: decreased miniature excitatory postsynaptic current frequency
def: "decrease in the number of occurrences of miniature excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced mEPSC frequency" EXACT []
synonym: "reduced miniature excitatory post-synaptic current frequency" EXACT []
is_a: MP:0014374 ! abnormal miniature excitatory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T18:51:15Z" xsd:dateTime

[Term]
id: MP:0014377
name: abnormal excitatory postsynaptic current frequency
def: "any anomaly in the number of occurrences of excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal EPSC frequency" EXACT []
synonym: "abnormal excitatory post-synaptic current frequency" EXACT []
is_a: MP:0002910 ! abnormal excitatory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:00:35Z" xsd:dateTime

[Term]
id: MP:0014378
name: increased excitatory postsynaptic current frequency
def: "increase in the number of occurrences of excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated EPSC frequency" EXACT []
synonym: "increased excitatory post-synaptic current frequency" EXACT []
is_a: MP:0014377 ! abnormal excitatory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:01:20Z" xsd:dateTime

[Term]
id: MP:0014379
name: decreased excitatory postsynaptic current frequency
def: "decrease in the number of occurrences of excitatory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased excitatory post-synaptic current frequency" EXACT []
synonym: "reduced EPSC frequency" EXACT []
is_a: MP:0014377 ! abnormal excitatory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:01:29Z" xsd:dateTime

[Term]
id: MP:0014380
name: abnormal miniature inhibitory postsynaptic current amplitude
def: "anomaly in the size (height or maximum displacement) or shape of the miniature inhibitory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal miniature inhibitory post-synaptic current amplitude" EXACT []
synonym: "abnormal mIPSC amplitude" EXACT []
synonym: "abnormal sIPSC amplitude" EXACT []
synonym: "abnormal spontaneous inhibitory post-synaptic current amplitude" EXACT []
is_a: MP:0009435 ! abnormal miniature inhibitory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:19:31Z" xsd:dateTime

[Term]
id: MP:0014381
name: abnormal miniature inhibitory postsynaptic current frequency
def: "any anomaly in the number of occurrences of miniature inhibitory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal miniature inhibitory post-synaptic current frequency" EXACT []
synonym: "abnormal mIPSC frequency" EXACT []
synonym: "abnormal sIPSC frequency" EXACT []
synonym: "abnormal spontaneous inhibitory post-synaptic current frequency" EXACT []
is_a: MP:0009435 ! abnormal miniature inhibitory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:19:41Z" xsd:dateTime

[Term]
id: MP:0014382
name: increased miniature inhibitory postsynaptic current frequency
def: "increase in the number of occurrences of miniature inhibitory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated mIPSC frequency" EXACT []
synonym: "increased miniature inhibitory post-synaptic current frequency" EXACT []
synonym: "increased sIPSC frequency" EXACT []
synonym: "increased spontaneous inhibitory post-synaptic current frequency" EXACT []
is_a: MP:0014381 ! abnormal miniature inhibitory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:20:02Z" xsd:dateTime

[Term]
id: MP:0014383
name: decreased miniature inhibitory postsynaptic current frequency
def: "decrease in the number of occurrences of miniature inhibitory postsynaptic currents per unit time" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased miniature inhibitory post-synaptic current frequency" EXACT []
synonym: "decreased sIPSC frequency" EXACT []
synonym: "decreased spontaneous inhibitory post-synaptic current frequency" EXACT []
synonym: "reduced mIPSC frequency" EXACT []
is_a: MP:0014381 ! abnormal miniature inhibitory postsynaptic current frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:20:11Z" xsd:dateTime

[Term]
id: MP:0014384
name: increased miniature inhibitory postsynaptic current amplitude
def: "increase in the size (height or maximum displacement) of the miniature inhibitory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated mIPSC amplitude" EXACT []
synonym: "increased miniature inhibitory post-synaptic current amplitude" EXACT []
synonym: "increased sIPSC amplitude" EXACT []
synonym: "increased spontaneous inhibitory post-synaptic current amplitude" EXACT []
is_a: MP:0014380 ! abnormal miniature inhibitory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:20:28Z" xsd:dateTime

[Term]
id: MP:0014385
name: decreased miniature inhibitory postsynaptic current amplitude
def: "decrease in the size (height or maximum displacement) of the miniature inhibitory postsynaptic current wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased miniature inhibitory post-synaptic current amplitude" EXACT []
synonym: "decreased sIPSC amplitude" EXACT []
synonym: "decreased spontaneous inhibitory post-synaptic current amplitude" EXACT []
synonym: "reduced mIPSC amplitude" EXACT []
is_a: MP:0014380 ! abnormal miniature inhibitory postsynaptic current amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T19:20:39Z" xsd:dateTime

[Term]
id: MP:0014386
name: decreased muscle fiber mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a muscle fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased muscle fiber mitochondrial genome size" EXACT []
synonym: "decreased muscle fiber mtDNA amount" EXACT []
synonym: "reduced muscle fiber mitochondrial DNA content" EXACT []
is_a: MP:0011639 ! decreased mitochondrial DNA content
is_a: MP:0014342 ! abnormal muscle fiber mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:05:22Z" xsd:dateTime

[Term]
id: MP:0014387
name: decreased neuron mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a neuron" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased neuron mitochondrial genome size" EXACT []
synonym: "decreased neuronal mtDNA amount" EXACT []
synonym: "reduced neuron mitochondrial DNA content" EXACT []
is_a: MP:0011639 ! decreased mitochondrial DNA content
is_a: MP:0014345 ! abnormal neuron mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:05:45Z" xsd:dateTime

[Term]
id: MP:0014388
name: decreased hepatocyte mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a hepatocyte" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased hepatocyte mitochondrial genome size" EXACT []
synonym: "decreased hepatocyte mtDNA amount" EXACT []
synonym: "reduced hepatocyte mitochondrial DNA content" EXACT []
is_a: MP:0011639 ! decreased mitochondrial DNA content
is_a: MP:0014341 ! abnormal hepatocyte mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:05:57Z" xsd:dateTime

[Term]
id: MP:0014389
name: decreased skeletal muscle fiber mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a skeletal muscle fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased skeletal muscle fiber mitochondrial genome size" EXACT []
synonym: "decreased skeletal muscle fiber mtDNA amount" EXACT []
synonym: "reduced skeletal muscle fiber mitochondrial DNA content" EXACT []
is_a: MP:0014344 ! abnormal skeletal muscle fiber mitochondrial morphology
is_a: MP:0014386 ! decreased muscle fiber mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:07:32Z" xsd:dateTime

[Term]
id: MP:0014390
name: decreased myocardial fiber mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of a myocardial fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased adult cardiomyocyte mtDNA amount" EXACT []
synonym: "decreased myocardial fiber mitochondrial genome size" EXACT []
synonym: "reduced myocardial fiber mitochondrial DNA content" EXACT []
is_a: MP:0014343 ! abnormal myocardial fiber mitochondrial morphology
is_a: MP:0014386 ! decreased muscle fiber mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:07:52Z" xsd:dateTime

[Term]
id: MP:0014391
name: increased hepatocyte mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a hepatocyte" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated hepatocyte mitochondrial DNA content" EXACT []
synonym: "increased hepatocyte mitochondrial genome size" EXACT []
synonym: "increased hepatocyte mtDNA amount" EXACT []
is_a: MP:0014341 ! abnormal hepatocyte mitochondrial morphology
is_a: MP:0030937 ! increased mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:08:23Z" xsd:dateTime

[Term]
id: MP:0014392
name: increased neuron mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a neuron" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated neuron mitochondrial DNA content" EXACT []
synonym: "increased neuron mitochondrial genome size" EXACT []
synonym: "increased neuron mtDNA amount" EXACT []
is_a: MP:0014345 ! abnormal neuron mitochondrial morphology
is_a: MP:0030937 ! increased mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:08:43Z" xsd:dateTime

[Term]
id: MP:0014393
name: increased muscle fiber mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a muscle fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated muscle fiber mitochondrial DNA content" EXACT []
synonym: "increased muscle fiber mitochondrial genome size" EXACT []
synonym: "increased muscle fiber mtDNA amount" EXACT []
is_a: MP:0014342 ! abnormal muscle fiber mitochondrial morphology
is_a: MP:0030937 ! increased mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:08:56Z" xsd:dateTime

[Term]
id: MP:0014394
name: increased skeletal muscle fiber mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a skeletal muscle fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated skeletal muscle fiber mitochondrial DNA content" EXACT []
synonym: "increased skeletal muscle fiber mitochondrial genome size" EXACT []
synonym: "increased skeletal muscle fiber mtDNA amount" EXACT []
is_a: MP:0014344 ! abnormal skeletal muscle fiber mitochondrial morphology
is_a: MP:0014393 ! increased muscle fiber mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:09:13Z" xsd:dateTime

[Term]
id: MP:0014395
name: increased myocardial fiber mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a myocardial fiber" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated myocardial fiber mitochondrial DNA content" EXACT []
synonym: "increased adult cardiomyocyte mitochondrial genome size" EXACT []
synonym: "increased myocardial fiber mtDNA amount" EXACT []
is_a: MP:0014343 ! abnormal myocardial fiber mitochondrial morphology
is_a: MP:0014393 ! increased muscle fiber mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:09:30Z" xsd:dateTime

[Term]
id: MP:0014396
name: decreased fat cell mitochondrial DNA content
def: "less than expected amount of DNA contained within the mitochondria of an adipocyte" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased adipocyte mitochondrial genome size" EXACT []
synonym: "decreased lipocyte mtDNA amount" EXACT []
synonym: "reduced fat cell mitochondrial DNA content" EXACT []
is_a: MP:0011639 ! decreased mitochondrial DNA content
is_a: MP:0014398 ! abnormal fat cell mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:34:20Z" xsd:dateTime

[Term]
id: MP:0014397
name: increased fat cell mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of an adipocyte" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated fat cell mitochondrial DNA content" EXACT []
synonym: "increased adipocyte mitochondrial genome size" EXACT []
synonym: "increased lipocyte mtDNA amount" EXACT []
is_a: MP:0014398 ! abnormal fat cell mitochondrial morphology
is_a: MP:0030937 ! increased mitochondrial DNA content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:34:42Z" xsd:dateTime

[Term]
id: MP:0014398
name: abnormal fat cell mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in fat cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal adipocyte mitochondria morphology" EXACT []
synonym: "abnormal lipocyte mitochondrion morphology" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
is_a: MP:0009115 ! abnormal fat cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T20:42:08Z" xsd:dateTime

[Term]
id: MP:0014399
name: decreased hematopoietic precursor cell number
def: "less than the expected number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased HPC number" EXACT []
synonym: "reduced haematopoietic precursor cell number" EXACT []
is_a: MP:0013708 ! abnormal hematopoietic precursor cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T21:04:25Z" xsd:dateTime

[Term]
id: MP:0014400
name: increased hematopoietic precursor cell number
def: "greater than the expected number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated haematopoietic precursor cell number" EXACT []
synonym: "increased HPC number" EXACT []
is_a: MP:0013708 ! abnormal hematopoietic precursor cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T21:04:37Z" xsd:dateTime

[Term]
id: MP:0014401
name: absent hematopoietic precursor cells
def: "absence of all hematopoietic cells that are a precursor of some other hematopoietic cell type" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent haematopoietic precursor cell number" EXACT []
synonym: "absent HPCs" EXACT []
is_a: MP:0014399 ! decreased hematopoietic precursor cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T21:04:50Z" xsd:dateTime

[Term]
id: MP:0014402
name: abnormal Reissner's fiber morphology
def: "any structural anomaly in the acellular strand that runs from subcommissural organ caudally through the ventricular system and central canal to the ampulla caudalis" [http://purl.obolibrary.org/obo/UBERON_0011357, PMID:38049798]
synonym: "abnormal Reissner's fibre morphology" EXACT []
is_a: MP:0003632 ! abnormal nervous system morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-06T21:25:21Z" xsd:dateTime

[Term]
id: MP:0014403
name: decreased early pro-B cell number
def: "reduced number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced number of early pro-B cells" EXACT []
is_a: MP:0005019 ! abnormal early pro-B cell
is_a: MP:0008208 ! decreased pro-B cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-21T20:44:23Z" xsd:dateTime

[Term]
id: MP:0014404
name: decreased late pro-B cell number
def: "reduced number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced number of late pro-B cells" EXACT []
is_a: MP:0005020 ! abnormal late pro-B cell
is_a: MP:0008208 ! decreased pro-B cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-21T20:44:55Z" xsd:dateTime

[Term]
id: MP:0014405
name: abnormal distortion product otoacoustic emission threshold
def: "any anomaly in the sound pressure required to evoke distortion product emission signal reliably above the noise noise level" [PMID:16901941]
synonym: "abnormal DPOAE threshold" EXACT []
is_a: MP:0004736 ! abnormal distortion product otoacoustic emission
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:16:00Z" xsd:dateTime

[Term]
id: MP:0014406
name: increased or absent distortion product otoacoustic emission threshold
def: "elevation in the sound pressure required to evoke distortion product emission signal reliably above the noise noise level or failure to evoke a response at the highest sound pressue tested" [PMID:16901941]
synonym: "elvated or absent DPOAE threshold" EXACT []
is_a: MP:0014405 ! abnormal distortion product otoacoustic emission threshold
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:26:28Z" xsd:dateTime

[Term]
id: MP:0014407
name: decreased distortion product otoacoustic emission threshold
def: "decrease in the sound pressure required to evoke distortion product emission signal reliably above the noise noise level" [PMID:16901941]
synonym: "reduced DPOAE threshold" EXACT []
is_a: MP:0014405 ! abnormal distortion product otoacoustic emission threshold
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:26:38Z" xsd:dateTime

[Term]
id: MP:0014408
name: abnormal distortion product otoacoustic emission amplitude
def: "anomaly in the size (height or maximum displacement) or shape of the sound wave produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies" [PMID:10575115, PMID:16648588]
synonym: "abnormal DPOAE amplitude" EXACT []
is_a: MP:0004736 ! abnormal distortion product otoacoustic emission
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:31:47Z" xsd:dateTime

[Term]
id: MP:0014409
name: decreased distortion product otoacoustic emission amplitude
def: "reduction in the size (height or maximum displacement) of the sound wave produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies" [PMID:16648588]
synonym: "reduced DPOAE amplitude" EXACT []
is_a: MP:0014408 ! abnormal distortion product otoacoustic emission amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:46:49Z" xsd:dateTime

[Term]
id: MP:0014410
name: increased distortion product otoacoustic emission amplitude
def: "increase in the size (height or maximum displacement) of the sound wave produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated DPOAE amplitude" EXACT []
is_a: MP:0014408 ! abnormal distortion product otoacoustic emission amplitude
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T19:46:58Z" xsd:dateTime

[Term]
id: MP:0014411
name: abnormal outer hair cell stereocilia length
synonym: "abnormal OHC stereocilia length" EXACT []
synonym: "any anomaly in the length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" EXACT [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004527 ! abnormal outer hair cell stereociliary bundle morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T20:08:51Z" xsd:dateTime

[Term]
id: MP:0014412
name: long outer hair cell stereocilia
def: "increased length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cell" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased OHC stereocilia length" EXACT []
is_a: MP:0014411 ! abnormal outer hair cell stereocilia length
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T20:15:14Z" xsd:dateTime

[Term]
id: MP:0014413
name: decreased depression-related behavior
def: "reduced responses to a stressful situation or stimulus, or increased tendency to seek pleasurable stimuli" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced depression-related behaviour" EXACT []
is_a: MP:0003360 ! abnormal depression-related behavior
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T20:35:52Z" xsd:dateTime

[Term]
id: MP:0014414
name: increased depression-related behavior
def: "elevated responses to a stressful situation or stimulus, or decreased tendency to seek pleasurable stimuli" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated depression-related behaviour" EXACT []
is_a: MP:0003360 ! abnormal depression-related behavior
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-22T20:36:08Z" xsd:dateTime

[Term]
id: MP:0014415
name: increased social novelty preference
def: "increase in the time spent with or preference for interactions with a novel individual of the same species versus with a familiar individual of the same species" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated social novelty preference" EXACT []
is_a: MP:0020395 ! abnormal response to social novelty
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-26T20:33:37Z" xsd:dateTime

[Term]
id: MP:0014416
name: decreased social novelty preference
def: "reduction in the time spent with or preference for interactions with a novel individual of the same species versus with a familiar individual of the same species" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced social novelty preference" EXACT []
is_a: MP:0020395 ! abnormal response to social novelty
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-26T20:33:57Z" xsd:dateTime

[Term]
id: MP:0014417
name: abnormal liver secretion
def: "any anomaly in the production or release of substances by cells of the liver" [http://purl.obolibrary.org/obo/GO_0046903, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000609 ! abnormal liver physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:13:19Z" xsd:dateTime

[Term]
id: MP:0014418
name: decreased liver secretion
def: "reduction in the production or release of substances by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced liver secretion" EXACT []
is_a: MP:0014417 ! abnormal liver secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:13:45Z" xsd:dateTime

[Term]
id: MP:0014419
name: increased liver secretion
def: "increase in the production or release of substances by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated liver secretion" EXACT []
is_a: MP:0014417 ! abnormal liver secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:13:55Z" xsd:dateTime

[Term]
id: MP:0014420
name: abnormal liver triglyceride secretion
def: "any anomaly in the production or release of triglycerides by cells of the liver" [https://orcid.org/0000-0003-4606-0597, PMID:38194265]
is_a: MP:0014417 ! abnormal liver secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:14:10Z" xsd:dateTime

[Term]
id: MP:0014421
name: abnormal liver apolipoprotein B secretion
def: "any anomaly in the production or release of apolipoprotein B by cells of the liver" [https://orcid.org/0000-0003-4606-0597, PMID:38194265]
is_a: MP:0014417 ! abnormal liver secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:14:26Z" xsd:dateTime

[Term]
id: MP:0014422
name: increased liver apolipoprotein B secretion
def: "increase in the production or release of apolipoprotein B by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated liver apolipoprotein B secretion" EXACT []
is_a: MP:0014419 ! increased liver secretion
is_a: MP:0014421 ! abnormal liver apolipoprotein B secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:15:23Z" xsd:dateTime

[Term]
id: MP:0014423
name: decreased liver apolipoprotein B secretion
def: "reduction in the production or release of apolipoprotein B by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced liver apolipoprotein B secretion" EXACT []
is_a: MP:0014418 ! decreased liver secretion
is_a: MP:0014421 ! abnormal liver apolipoprotein B secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:15:32Z" xsd:dateTime

[Term]
id: MP:0014424
name: increased liver triglyceride secretion
def: "increase in the production or release of triglycerides by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated liver triglyceride secretion" EXACT []
is_a: MP:0014419 ! increased liver secretion
is_a: MP:0014420 ! abnormal liver triglyceride secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:15:50Z" xsd:dateTime

[Term]
id: MP:0014425
name: decreased liver triglyceride secretion
def: "reduction in the production or release of triglycerides by cells of the liver" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced liver triglyceride secretion" EXACT []
is_a: MP:0014418 ! decreased liver secretion
is_a: MP:0014420 ! abnormal liver triglyceride secretion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T14:15:59Z" xsd:dateTime

[Term]
id: MP:0014426
name: abnormal hyaluronic acid level
def: "any anomaly in the amount of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal hyaluronan level" EXACT []
is_a: MP:0011475 ! abnormal glycosaminoglycan level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:07:30Z" xsd:dateTime

[Term]
id: MP:0014427
name: increased circulating hyaluronic acid level
def: "more than the expected amount in the blood of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating hyaluronan level" EXACT []
is_a: MP:0014429 ! increased hyaluronic acid level
is_a: MP:0020341 ! abnormal circulating hyaluronic acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:12:20Z" xsd:dateTime

[Term]
id: MP:0014428
name: decreased circulating hyaluronic acid level
def: "less than the expected amount in the blood of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating hyaluronan level" EXACT []
is_a: MP:0014430 ! decreased hyaluronic acid level
is_a: MP:0020341 ! abnormal circulating hyaluronic acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:12:30Z" xsd:dateTime

[Term]
id: MP:0014429
name: increased hyaluronic acid level
def: "more than the expected amount of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated hyaluronan level" EXACT []
is_a: MP:0014426 ! abnormal hyaluronic acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:18:38Z" xsd:dateTime

[Term]
id: MP:0014430
name: decreased hyaluronic acid level
def: "less than the expected amount of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced hyaluronan level" EXACT []
is_a: MP:0014426 ! abnormal hyaluronic acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:18:47Z" xsd:dateTime

[Term]
id: MP:0014431
name: increased chemokine level
def: "more than the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated chemokine level" EXACT []
is_a: MP:0008721 ! abnormal chemokine level
is_a: MP:0014433 ! increased cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:41:28Z" xsd:dateTime

[Term]
id: MP:0014432
name: decreased chemokine level
def: "less than the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced chemokine level" EXACT []
is_a: MP:0008721 ! abnormal chemokine level
is_a: MP:0014434 ! decreased cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:41:37Z" xsd:dateTime

[Term]
id: MP:0014433
name: increased cytokine level
def: "more than the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated cytokine level" EXACT []
is_a: MP:0008713 ! abnormal cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:47:17Z" xsd:dateTime

[Term]
id: MP:0014434
name: decreased cytokine level
def: "less than the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced cytokine level" EXACT []
is_a: MP:0008713 ! abnormal cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:47:30Z" xsd:dateTime

[Term]
id: MP:0014435
name: increased interferon level
def: "more than the normal levels of of interferons" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated interferon level" EXACT []
is_a: MP:0008750 ! abnormal interferon level
is_a: MP:0014433 ! increased cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:53:00Z" xsd:dateTime

[Term]
id: MP:0014436
name: decreased interferon level
def: "less than the normal levels of of interferons" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced interferon level" EXACT []
is_a: MP:0008750 ! abnormal interferon level
is_a: MP:0014434 ! decreased cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:53:10Z" xsd:dateTime

[Term]
id: MP:0014437
name: increased interleukin level
def: "more than the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated interleukin level" EXACT []
is_a: MP:0008751 ! abnormal interleukin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:58:24Z" xsd:dateTime

[Term]
id: MP:0014438
name: decreased interleukin level
def: "less than the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced interleukin level" EXACT []
is_a: MP:0008751 ! abnormal interleukin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-03-27T19:58:33Z" xsd:dateTime

[Term]
id: MP:0014439
name: abnormal response to leptin
def: "any anomaly in the ability of leptin to modulate energy intake and energy expenditure" [PMID:34646989]
synonym: "abnormal leptin resistance" NARROW []
synonym: "abnormal leptin sensitivity" NARROW []
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-17T20:48:53Z" xsd:string

[Term]
id: MP:0014440
name: increased response to leptin
def: "greater than the expected ability of leptin to modulate energy intake and energy expenditure" [PMID:34646989]
synonym: "decreased leptin resistance" NARROW []
synonym: "enhanced leptin sensitivity" NARROW []
synonym: "impaired leptin resistance" NARROW []
synonym: "increased leptin sensitivity" NARROW []
is_a: MP:0014439 ! abnormal response to leptin
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-17T20:51:45Z" xsd:dateTime

[Term]
id: MP:0014441
name: decreased response to leptin
def: "less than the expected ability of leptin to modulate energy intake and energy expenditure" [PMID:34646989]
synonym: "decreased leptin sensitivity" NARROW []
synonym: "enhanced leptin resistance" NARROW []
synonym: "impaired leptin sensitivity" NARROW []
synonym: "increased leptin resistance" NARROW []
is_a: MP:0014439 ! abnormal response to leptin
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-17T20:51:59Z" xsd:dateTime

[Term]
id: MP:0014442
name: abnormal polar body extrusion
def: "any anomaly in the cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum" [GO:0040038]
synonym: "abnormal polar body extrusion after meiotic divisions" EXACT []
is_a: MP:0005168 ! abnormal female meiosis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:21:49Z" xsd:dateTime

[Term]
id: MP:0014443
name: impaired polar body extrusion
def: "impaired or reduced function of the cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum" [GO:0040038, PMID:38546043]
synonym: "reduced polar body extrusion after meiotic divisions" EXACT []
is_a: MP:0014442 ! abnormal polar body extrusion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:22:04Z" xsd:dateTime

[Term]
id: MP:0014444
name: enhanced polar body extrusion
def: "enhanced or increased function of the cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum" [GO:0040038]
synonym: "increased polar body extrusion after meiotic divisions" EXACT []
is_a: MP:0014442 ! abnormal polar body extrusion
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:22:18Z" xsd:dateTime

[Term]
id: MP:0014445
name: abnormal spindle assembly in female meiosis
def: "any anomaly in the aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females" [GO:0007056]
synonym: "abnormal female meiotic spindle assembly" EXACT []
synonym: "abnormal spindle assembly involved in female meiosis" EXACT []
is_a: MP:0005168 ! abnormal female meiosis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:31:08Z" xsd:dateTime

[Term]
id: MP:0014446
name: enhanced spindle assembly in female meiosis
def: "enhancement of the aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females" [GO:0007056]
synonym: "improved female meiotic spindle assembly" EXACT []
synonym: "increased spindle assembly involved in female meiosis" EXACT []
is_a: MP:0014445 ! abnormal spindle assembly in female meiosis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:31:24Z" xsd:dateTime

[Term]
id: MP:0014447
name: impaired spindle assembly in female meiosis
def: "impairment of the aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females" [GO:0007056]
synonym: "decreased female meiotic spindle assembly" EXACT []
synonym: "reduced spindle assembly involved in female meiosis" EXACT []
is_a: MP:0014445 ! abnormal spindle assembly in female meiosis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T14:31:43Z" xsd:dateTime

[Term]
id: MP:0014448
name: increased enzyme/coenzyme level
def: "elevated level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated enzyme/coenzyme level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:01:13Z" xsd:dateTime

[Term]
id: MP:0014449
name: decreased enzyme/coenzyme level
def: "reduced level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced enzyme/coenzyme level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:01:30Z" xsd:dateTime

[Term]
id: MP:0014450
name: increased circulating enzyme level
def: "elevated concentration in the blood of any of the proteins that act as catalysts for biological reactions" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating enzyme level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:08:47Z" xsd:dateTime

[Term]
id: MP:0014451
name: decreased circulating enzyme level
def: "reduced concentration in the blood of any of the proteins that act as catalysts for biological reactions" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating enzyme level" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:08:56Z" xsd:dateTime

[Term]
id: MP:0014452
name: increased nitric oxide synthase level
def: "increase in the concentration of the enzyme(s) that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated ntric oxide synthase concentration" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:53:08Z" xsd:dateTime

[Term]
id: MP:0014453
name: decreased nitric oxide synthase level
def: "decrease in the concentration of the enzyme(s) that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced ntric oxide synthase concentration" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T18:53:17Z" xsd:dateTime

[Term]
id: MP:0014454
name: increased hormone level
def: "elevation in the tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated hormone level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T19:33:14Z" xsd:dateTime

[Term]
id: MP:0014455
name: decreased hormone level
def: "reduction in the tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced hormone level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T19:33:26Z" xsd:dateTime

[Term]
id: MP:0014456
name: increased circulating hormone level
def: "increase in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organ" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating hormone concentration" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0014454 ! increased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T19:41:45Z" xsd:dateTime

[Term]
id: MP:0014457
name: decreased circulating hormone level
def: "reduction in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organ" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating hormone concentration" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0014455 ! decreased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T19:41:57Z" xsd:dateTime

[Term]
id: MP:0014458
name: increased urine hormone level
def: "elevation in the urine amount of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated urine hormone concentration" EXACT []
is_a: MP:0011538 ! abnormal urine hormone level
is_a: MP:0014454 ! increased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T20:19:41Z" xsd:dateTime

[Term]
id: MP:0014459
name: decreased urine hormone level
def: "reduction in the urine amount of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced urine hormone concentration" EXACT []
is_a: MP:0011538 ! abnormal urine hormone level
is_a: MP:0014455 ! decreased hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-18T20:19:55Z" xsd:dateTime

[Term]
id: MP:0014460
name: increased lipid level
def: "increase in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated lipid concentration" EXACT []
synonym: "increased lipid storage" NARROW []
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-23T19:59:12Z" xsd:dateTime

[Term]
id: MP:0014461
name: decreased lipid level
def: "reduction in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased lipid storage" NARROW []
synonym: "reduced lipid concentration" EXACT []
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-04-23T19:59:23Z" xsd:dateTime

[Term]
id: MP:0014462
name: abnormal sperm mitochondrial sheath size
def: "anomaly in the size of the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009832 ! abnormal sperm mitochondrial sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:39:02Z" xsd:dateTime

[Term]
id: MP:0014463
name: increased sperm mitochondrial sheath size
def: "increased size of the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged sperm mitochondrial sheath" EXACT []
is_a: MP:0014462 ! abnormal sperm mitochondrial sheath size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:43:02Z" xsd:dateTime

[Term]
id: MP:0014464
name: decreased sperm mitochondrial sheath size
def: "decreased size of the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced sperm mitochondrial sheath size" EXACT []
synonym: "small sperm mitochondrial sheath" EXACT []
is_a: MP:0014462 ! abnormal sperm mitochondrial sheath size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:43:33Z" xsd:dateTime

[Term]
id: MP:0014465
name: abnormal sperm mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sperm mitochondria morphology" EXACT []
is_a: MP:0006035 ! abnormal mitochondrial morphology
is_a: MP:0009832 ! abnormal sperm mitochondrial sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:50:09Z" xsd:dateTime

[Term]
id: MP:0014466
name: decreased sperm mitochondrial size
def: "reduced size of the cellular organelles responsible for energy production in the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced sperm mitochondrion size" EXACT []
synonym: "small sperm mitochondria" EXACT []
is_a: MP:0011631 ! decreased mitochondrial size
is_a: MP:0014465 ! abnormal sperm mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:51:09Z" xsd:dateTime

[Term]
id: MP:0014467
name: increased sperm mitochondrial size
def: "increased size of the cellular organelles responsible for energy production in the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged sperm mitochondria" EXACT []
is_a: MP:0011630 ! increased mitochondrial size
is_a: MP:0014465 ! abnormal sperm mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T17:51:26Z" xsd:dateTime

[Term]
id: MP:0014468
name: disorganized sperm mitochondrial sheath
def: "derangement of the normal tightly packed helical pattern of the sperm mitochondrial sheath" [https://orcid.org/0000-0003-4606-0597]
synonym: "disorganised sperm mitochondrial sheath" EXACT []
is_a: MP:0009832 ! abnormal sperm mitochondrial sheath morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T18:37:20Z" xsd:dateTime

[Term]
id: MP:0014469
name: abnormal B cell calcium ion homeostasis
def: "any anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the B cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal B cell calcium flux" NARROW []
synonym: "abnormal B cell calcium homeostasis" EXACT []
is_a: MP:0002459 ! abnormal B cell physiology
is_a: MP:0004231 ! abnormal calcium ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T19:07:29Z" xsd:dateTime

[Term]
id: MP:0014470
name: abnormal B cell migration
def: "any anomaly in the ability of B cells to move within or between different tissues and organs of the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal B lymphocyte trafficking" NARROW []
is_a: MP:0002459 ! abnormal B cell physiology
is_a: MP:0003156 ! abnormal leukocyte migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T19:15:52Z" xsd:dateTime

[Term]
id: MP:0014471
name: enhanced B cell migration
def: "enhanced ability of B cells to move within or between different tissues and organs of the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased B lymphocyte trafficking" NARROW []
is_a: MP:0014470 ! abnormal B cell migration
is_a: MP:0020213 ! enhanced leukocyte migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T19:24:26Z" xsd:dateTime

[Term]
id: MP:0014472
name: impaired B cell migration
def: "impaired ability of B cells to move within or between different tissues and organs of the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased B lymphocyte trafficking" NARROW []
synonym: "reduced B cell migration" EXACT []
is_a: MP:0014470 ! abnormal B cell migration
is_a: MP:0020212 ! impaired leukocyte migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-05-28T19:24:41Z" xsd:dateTime

[Term]
id: MP:0014473
name: increased pulmonary alveolus wall thickness
def: "increase in the width of the tissue that encloses the alveolar space of the lung" [https://orcid.org/0000-0003-4606-0597, PMID:37890669]
synonym: "thick pulmonary alveolar wall" EXACT []
is_a: MP:0010903 ! abnormal pulmonary alveolus wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-07T20:47:13Z" xsd:dateTime

[Term]
id: MP:0014474
name: decreased pulmonary alveolus wall thickness
def: "decrease in the width of the tissue that encloses the alveolar space of the lung" [https://orcid.org/0000-0003-4606-0597, PMID:37890669]
synonym: "reduced pulmonary alveolus wall thickness" EXACT []
synonym: "thin pulmonary alveolar wall" EXACT []
is_a: MP:0010903 ! abnormal pulmonary alveolus wall morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-07T20:47:42Z" xsd:dateTime

[Term]
id: MP:0014475
name: abnormal feces bile salt level
def: "any anomaly in the amount of bile acids found in the feces" [] {def="PMID:12819193"}
synonym: "abnormal faeces bile amount" EXACT []
synonym: "abnormal fecal bile acid level" EXACT []
synonym: "abnormal feces bile salt content" EXACT []
is_a: MP:0004774 ! abnormal bile salt level
is_a: MP:0014476 ! abnormal feces lipid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T15:35:57Z" xsd:dateTime

[Term]
id: MP:0014476
name: abnormal feces lipid level
def: "any anomaly in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the feces" [PMID:18335062]
synonym: "abnormal faeces lipid amount" EXACT []
synonym: "abnormal feces lipid content" EXACT []
is_a: MP:0001547 ! abnormal lipid level
is_a: MP:0003868 ! abnormal feces composition
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T15:42:54Z" xsd:dateTime

[Term]
id: MP:0014477
name: abnormal feces cholesterol level
def: "anomaly in the amount in the feces of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones" [PMID:12915407]
synonym: "abnormal faeces cholesterol amount" EXACT []
synonym: "abnormal feces cholesterol content" EXACT []
is_a: MP:0003947 ! abnormal cholesterol level
is_a: MP:0014476 ! abnormal feces lipid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T17:27:35Z" xsd:dateTime

[Term]
id: MP:0014478
name: increased feces bile salt level
def: "increase in the amount of bile acids found in the feces" [PMID:12819193]
synonym: "elevated faeces bile salt amount" EXACT []
synonym: "increased feces bile salt content" EXACT []
is_a: MP:0004789 ! increased bile salt level
is_a: MP:0014475 ! abnormal feces bile salt level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T17:33:36Z" xsd:dateTime

[Term]
id: MP:0014479
name: decreased feces bile salt level
def: "reduced amount of bile acids found in the feces" [PMID:12819193]
synonym: "decreased feces bile salt content" EXACT []
synonym: "reduced faeces bile salt amount" EXACT []
is_a: MP:0012338 ! decreased bile salt level
is_a: MP:0014475 ! abnormal feces bile salt level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T17:33:45Z" xsd:dateTime

[Term]
id: MP:0014480
name: increased feces cholesterol level
def: "elevated amount in the feces of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones" [PMID:12915407]
synonym: "increased faeces cholesterol amount" EXACT []
synonym: "increased feces cholesterol content" EXACT []
is_a: MP:0003982 ! increased cholesterol level
is_a: MP:0014477 ! abnormal feces cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T17:34:07Z" xsd:dateTime

[Term]
id: MP:0014481
name: decreased feces cholesterol level
def: "reduced amount in the feces of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones" [PMID:12915407]
synonym: "decreased feces cholesterol content" EXACT []
synonym: "reduced faeces cholesterol amount" EXACT []
is_a: MP:0003983 ! decreased cholesterol level
is_a: MP:0014477 ! abnormal feces cholesterol level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T17:34:21Z" xsd:dateTime

[Term]
id: MP:0014482
name: abnormal feces water content
def: "any anomaly in the amount of water in the feces" [PMID:19075008]
synonym: "abnormal faeces water level" EXACT []
is_a: MP:0003868 ! abnormal feces composition
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T19:57:43Z" xsd:dateTime

[Term]
id: MP:0014483
name: increased feces water content
def: "increase in the amount of water in the feces" [PMID:19075008]
synonym: "increased faeces water level" EXACT []
is_a: MP:0014482 ! abnormal feces water content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T19:58:05Z" xsd:dateTime

[Term]
id: MP:0014484
name: decreased feces water content
def: "decrease in the amount of water in the feces" [PMID:19075008]
synonym: "reduced faeces water level" EXACT []
is_a: MP:0014482 ! abnormal feces water content
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-18T19:58:22Z" xsd:dateTime

[Term]
id: MP:0014485
name: abnormal miniature inhibitory postsynaptic current decay phase
def: "any anomaly in the part of the miniature postsynaptic current wave that occurs after the peak amplitude during the return to baseline" [PMID:26291161]
is_a: MP:0009435 ! abnormal miniature inhibitory postsynaptic currents
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T16:08:27Z" xsd:dateTime

[Term]
id: MP:0014486
name: prolonged miniature inhibitory postsynaptic current decay phase
def: "increase in the duration of the part of the miniature postsynaptic current wave that occurs after the peak amplitude during the return to baseline" [PMID:26291161]
synonym: "increased miniature inhibitory postsynaptic current decay time" NARROW []
is_a: MP:0014485 ! abnormal miniature inhibitory postsynaptic current decay phase
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T16:08:53Z" xsd:dateTime

[Term]
id: MP:0014487
name: reduced miniature inhibitory postsynaptic current decay phase
def: "decrease in the duration of the part of the miniature postsynaptic current wave that occurs after the peak amplitude during the return to baseline" [PMID:26291161]
synonym: "decreased miniature inhibitory postsynaptic current decay time" NARROW []
is_a: MP:0014485 ! abnormal miniature inhibitory postsynaptic current decay phase
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T16:09:44Z" xsd:dateTime

[Term]
id: MP:0014488
name: abnormal skin sensory neuron innervation pattern
def: "any anomaly in the placement, morphology or number of sensory nerve fibers in the skin" [https://orcid.org/0000-0003-4606-0597, PMID:18830272]
synonym: "abnormal skin sensory neuron projections" EXACT []
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
is_a: MP:0002060 ! abnormal skin morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T17:49:51Z" xsd:dateTime

[Term]
id: MP:0014489
name: abnormal cochlear sensory neuron innervation pattern
def: "any anomaly in the placement, morphology or number of sensory nerve fibers in the cochlea" [PMID:7588071]
synonym: "abnormal cochlea sensory neuron projections" EXACT []
is_a: MP:0000031 ! abnormal cochlea morphology
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T17:54:36Z" xsd:dateTime

[Term]
id: MP:0014490
name: abnormal inner ear vestibular sensory neuron innervation pattern
def: "any anomaly in the placement, morphology or number sensory nerve fibers in the vestibule of the inner ear" [PMID:11877382]
synonym: "abnormal inner ear vestibular sensory neuron projections" EXACT []
synonym: "abnormal inner ear vestibule sensory neuron innervation pattern" EXACT []
is_a: MP:0000034 ! abnormal inner ear vestibule morphology
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T18:01:09Z" xsd:dateTime

[Term]
id: MP:0014491
name: abnormal mammary gland sensory innervation pattern
def: "any anomaly in the placement, morphology or number of sensory nerve fibers in the mammary gland" [PMID:23224557]
synonym: "abnormal mammary gland sensory neuron projections" EXACT []
is_a: MP:0000627 ! abnormal mammary gland morphology
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T18:20:13Z" xsd:dateTime

[Term]
id: MP:0014492
name: abnormal retinal sensory neuron innervation pattern
def: "any anomaly in the placement, morphology or number of axons from retinal neurons to an effector tissue or to retinal targets in the brain" [PMID:15014130]
synonym: "abnormal retina sensory neuron innervation pattern" EXACT []
synonym: "abnormal retinal sensory neuron projections" EXACT []
is_a: MP:0000968 ! abnormal sensory neuron innervation pattern
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T18:37:04Z" xsd:dateTime

[Term]
id: MP:0014493
name: increased circulating cytokine level
def: "increase in the blood levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010210 ! abnormal circulating cytokine level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:04:54Z" xsd:dateTime

[Term]
id: MP:0014494
name: decreased circulating cytokine level
def: "reduction in the blood levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating cytokine level" EXACT []
is_a: MP:0010210 ! abnormal circulating cytokine level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:05:14Z" xsd:dateTime

[Term]
id: MP:0014495
name: increased circulating chemokine level
def: "elevated levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating chemokine level" EXACT []
is_a: MP:0010209 ! abnormal circulating chemokine level
is_a: MP:0014431 ! increased chemokine level
is_a: MP:0014493 ! increased circulating cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:12:54Z" xsd:dateTime

[Term]
id: MP:0014496
name: decreased circulating chemokine level
def: "reduction in the levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating chemokine level" EXACT []
is_a: MP:0010209 ! abnormal circulating chemokine level
is_a: MP:0014432 ! decreased chemokine level
is_a: MP:0014494 ! decreased circulating cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:13:06Z" xsd:dateTime

[Term]
id: MP:0014497
name: increased circulating interleukin level
def: "increase in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell type" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated circulating IL level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level
is_a: MP:0014437 ! increased interleukin level
is_a: MP:0014493 ! increased circulating cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:23:56Z" xsd:dateTime

[Term]
id: MP:0014498
name: decreased circulating interleukin level
def: "decrease in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell type" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating IL level" EXACT []
is_a: MP:0008588 ! abnormal circulating interleukin level
is_a: MP:0014438 ! decreased interleukin level
is_a: MP:0014494 ! decreased circulating cytokine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T19:24:16Z" xsd:dateTime

[Term]
id: MP:0014499
name: increased acute phase protein level
def: "increase in the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:11:25Z" xsd:dateTime

[Term]
id: MP:0014500
name: decreased acute phase protein level
def: "reduction in the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [] {def="https://orcid.org/0000-0003-4606-0597"}
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:11:35Z" xsd:dateTime

[Term]
id: MP:0014501
name: increased circulating protein level
def: "increase in the amount in the blood of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:18:23Z" xsd:dateTime

[Term]
id: MP:0014502
name: decreased circulating protein level
def: "reduction in the amount in the blood of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005416 ! abnormal circulating protein level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:18:42Z" xsd:dateTime

[Term]
id: MP:0014503
name: decreased circulating myoglobin level
def: "decreased blood level of myoglobin, a low molecular weight oxygen binding heme protein that is normally found exclusively in heart and skeletal muscle cells; in blood, myoglobin is bound primarily to plasma globulins, a complex which is filtered by the kidneys; if the plasma concentration exceeds the plasma binding capacity, myoglobin begins to appear in the urine; myoglobin is rapidly released into the bloodstream after muscle damage, and thus can be a useful biomarker in the early phases of heart or skeletal muscle injury" [ISBN:9780124157590]
synonym: "reduced circulating myoglobin level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031107 ! abnormal circulating myoglobin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:53:40Z" xsd:dateTime

[Term]
id: MP:0014504
name: decreased circulating procalcitonin level
def: "reduced concentration in the blood of procalcitonin, a peptide precursor of the hormone calcitonin produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine; the level of procalcitonin is virtually undetectable in the bloodstream of healthy individuals but can rise significantly in systemic bacterial infections and sepsis; it does not rise significantly with viral or non-infectious inflammations" [https://en.wikipedia.org/wiki/Procalcitonin]
synonym: "reduced circulating procalcitonin level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031064 ! abnormal circulating procalcitonin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-06-21T20:56:49Z" xsd:dateTime

[Term]
id: MP:0014505
name: abnormal intestinal crypt stem cell morphology
def: "any structural anomaly in the cells found in the zone occupying the bottom region of the crypt that provide the source of most of the cell types of the intestinal epithelium, proliferate by mitotic division, and differentiate into columnar or goblet cells" [http://purl.obolibrary.org/obo/CL_0002250]
synonym: "abnormal stem cell of intestinal crypt of Lieberkuhn morphology" EXACT []
is_a: MP:0000488 ! abnormal intestinal epithelium morphology
is_a: MP:0000490 ! abnormal crypts of Lieberkuhn morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T19:54:25Z" xsd:dateTime

[Term]
id: MP:0014506
name: abnormal intestinal crypt stem cell number
def: "any anomaly in the number of intestinal crypt stem cells" [PMID:22354172]
synonym: "abnormal stem cell of intestinal crypt of Leberkuhn number" EXACT []
is_a: MP:0014505 ! abnormal intestinal crypt stem cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T19:58:35Z" xsd:dateTime

[Term]
id: MP:0014507
name: increased intestinal crypt stem cell number
def: "increase in the number of intestinal crypt stem cells" [PMID:22354172]
synonym: "elevated stem cell of intestinal crypt of Lieberkuhn number" EXACT []
is_a: MP:0014506 ! abnormal intestinal crypt stem cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:02:53Z" xsd:dateTime

[Term]
id: MP:0014508
name: decreased intestinal crypt stem cell number
def: "reduction in the number of intestinal crypt stem cells" [PMID:22354172]
synonym: "reduced stem cell of intestinal crypt of Lieberkuhn number" EXACT []
is_a: MP:0014506 ! abnormal intestinal crypt stem cell number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:03:02Z" xsd:dateTime

[Term]
id: MP:0014509
name: abnormal intestinal crypt stem cell physiology
def: "any functional anomaly in the cells found in the zone occupying the bottom region of the crypt that provide the source of most of the cell types of the intestinal epithelium, proliferate by mitotic division, and differentiate into columnar or goblet cells" [http://purl.obolibrary.org/obo/CL_0002250]
synonym: "abnormal stem cell of intestinal crypt of Lieberkuhn physiology" EXACT []
is_a: MP:0005621 ! abnormal cell physiology
is_a: MP:0014201 ! abnormal intestinal epithelium physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:14:22Z" xsd:dateTime

[Term]
id: MP:0014510
name: abnormal intestinal crypt stem cell proliferation
def: "any anomaly in the ability of intestinal crypt stem cells to undergo expansion by cell division" [PMID:38558797]
synonym: "abnormal stem cell of intestinal crypt of Lieberkuhn proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0014509 ! abnormal intestinal crypt stem cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:22:27Z" xsd:dateTime

[Term]
id: MP:0014511
name: increased intestinal crypt stem cell proliferation
def: "increase in the ability of intestinal crypt stem cells to undergo expansion by cell division" [PMID:38558797]
synonym: "elevated stem cell of intestinal crypt of Lieberkuhn proliferation" EXACT []
is_a: MP:0014510 ! abnormal intestinal crypt stem cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:25:34Z" xsd:dateTime

[Term]
id: MP:0014512
name: decreased intestinal crypt stem cell proliferation
def: "reduction in the ability of intestinal crypt stem cells to undergo expansion by cell division" [PMID:38558797]
synonym: "reduced stem cell of intestinal crypt of Lieberkuhn proliferation" EXACT []
is_a: MP:0014510 ! abnormal intestinal crypt stem cell proliferation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-07-02T20:25:49Z" xsd:dateTime

[Term]
id: MP:0014513
name: abnormal circulating anti-Mullerian hormone level
def: "any anomaly in the concentration in the blood of the heterodimeric glycoprotein hormone that plays an essential role in sex determination in early embryonic development" [PMID:34924282, PMID:36498783]
synonym: "aberrant circulating anti-Mullerian hormone concentration" EXACT []
synonym: "abnormal circulating AMH level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: dc:contributor https://orcid.org/0000-0001-5256-8683
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-06T17:05:02Z" xsd:dateTime

[Term]
id: MP:0014514
name: increased circulating anti-Mullerian hormone level
def: "increase in the concentration in the blood of the heterodimeric glycoprotein hormone that plays an essential role in sex determination in early embryonic development" [PMID:34256052]
synonym: "elevated circulating AMH concentration" EXACT []
is_a: MP:0014456 ! increased circulating hormone level
is_a: MP:0014513 ! abnormal circulating anti-Mullerian hormone level
property_value: dc:contributor https://orcid.org/0000-0001-5256-8683
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-06T17:05:17Z" xsd:dateTime

[Term]
id: MP:0014515
name: decreased circulating anti-Mullerian hormone level
def: "reduction in the concentration in the blood of the heterodimeric glycoprotein hormone that plays an essential role in sex determination in early embryonic development" [PMID:34256052]
synonym: "reduced circulating AMH concentration" EXACT []
is_a: MP:0014457 ! decreased circulating hormone level
is_a: MP:0014513 ! abnormal circulating anti-Mullerian hormone level
property_value: dc:contributor https://orcid.org/0000-0001-5256-8683
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-06T17:05:30Z" xsd:dateTime

[Term]
id: MP:0014516
name: abnormal middle ear development
def: "any anomaly in the development of the structures of any components of the tympanic cavity or its ossicles" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000049 ! abnormal middle ear morphology
is_a: MP:0003938 ! abnormal ear development
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-06T17:38:13Z" xsd:dateTime

[Term]
id: MP:0014517
name: abnormal outer ear development
def: "any anomaly in the development of any of the components of the auricles or external acoustic meatus" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002177 ! abnormal outer ear morphology
is_a: MP:0003938 ! abnormal ear development
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-06T17:38:27Z" xsd:dateTime

[Term]
id: MP:0014518
name: myocardial hypertrabeculation
def: "presence of prominent trabeculations and deep intratrabecular recesses in the wall of the heart; the recesses communicate with the main chamber and in some cases with the coronary circulation" [https://doi.org/10.1161/01.CIR.0000132478.60674.D, https://doi.org/10.1161/circ.105.9.e5, PMID:28798025, PMID:34206037]
synonym: "myocardial noncompaction" EXACT []
is_a: MP:0002189 ! abnormal myocardial trabeculae morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:01:26Z" xsd:dateTime

[Term]
id: MP:0014519
name: myocardial ventricular hypertrabeculation
def: "presence of prominent trabeculations and deep intratrabecular recesses in the wall of the ventricle; the recesses communicate with the main chamber and in some cases with the coronary circulation" [PMID:28798025, PMID:38951485]
synonym: "myocardial ventricular noncompaction" EXACT []
is_a: MP:0010499 ! abnormal ventricle myocardium morphology
is_a: MP:0014518 ! myocardial hypertrabeculation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:01:46Z" xsd:dateTime

[Term]
id: MP:0014520
name: myocardial atrial hypertrabeculation
def: "presence of prominent trabeculations and deep intratrabecular recesses in the wall of the atrium; the recesses communicate with the main chamber and in some cases with the coronary circulation" [PMID:34206037, PMID:38951485]
synonym: "myocardial atrial noncompaction" EXACT []
is_a: MP:0010581 ! abnormal atrium myocardial trabeculae morphology
is_a: MP:0014518 ! myocardial hypertrabeculation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:01:59Z" xsd:dateTime

[Term]
id: MP:0014521
name: abnormal response to brain injury
def: "altered response to acquired brain injury, including trauma caused by physical means (e.g. shocks, concussions, or incisions), lack of adequate blood flow, exposure to toxins or cold-induced stress, pressure from a tumor, etc" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal susceptibility to brain injury" NARROW []
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0005164 ! abnormal response to injury
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:42:09Z" xsd:dateTime

[Term]
id: MP:0014522
name: decreased response to brain injury
def: "less severe response, such as decreased incidence and/or size of necrotic tissue, to acquired brain injury, including trauma caused by physical means (e.g. shocks, concussions, or incisions), lack of adequate blood flow, exposure to toxins or cold-induced stress, pressure from a tumor, etc" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to brain injury" NARROW []
synonym: "elevated resistance to brain injury" NARROW []
synonym: "reduced response to brain injury" EXACT []
synonym: "reduced susceptibility to brain injury" NARROW []
is_a: MP:0014521 ! abnormal response to brain injury
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:43:16Z" xsd:dateTime

[Term]
id: MP:0014523
name: increased response to brain injury
def: "more severe response, such as increased incidence and/or size of necrotic tissue, to acquired brain injury, including trauma caused by physical means (e.g. shocks, concussions, or incisions), lack of adequate blood flow, exposure to toxins or cold-induced stress, pressure from a tumor, etc." [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to brain injury" NARROW []
synonym: "elevated susceptibility to brain injury" NARROW []
synonym: "enhanced response to brain injury" EXACT []
synonym: "reduced resistance to brain injury" NARROW []
is_a: MP:0014521 ! abnormal response to brain injury
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T19:43:27Z" xsd:dateTime

[Term]
id: MP:0014524
name: abnormal pulmonary alveolar fluid clearance
def: "any anomaly in the processes by which fluid is moved across the alveolar epithelium, this reabsorption is dependent on active ion transport" [PMID:27064541, PMID:36688689]
is_a: MP:0001784 ! abnormal fluid regulation
is_a: MP:0014026 ! abnormal respiratory epithelial transmembrane transport
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:24:33Z" xsd:dateTime

[Term]
id: MP:0014525
name: impaired pulmonary alveolar fluid clearance
def: "reduction in the processes by which fluid is moved across the alveolar epithelium, this reabsorption is dependent on active ion transport" [PMID:27064541]
synonym: "decreased alveolar fluid clearance" EXACT []
synonym: "reduced alveolar fluid clearance" EXACT []
is_a: MP:0014524 ! abnormal pulmonary alveolar fluid clearance
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:24:50Z" xsd:dateTime

[Term]
id: MP:0014526
name: enhanced pulmonary alveolar fluid clearance
def: "increase in the processes by which fluid is moved across the alveolar epithelium, this reabsorption is dependent on active ion transport" [PMID:27064541]
synonym: "elevated alveolar fluid clearance" EXACT []
synonym: "increased alveolar fluid clearance" EXACT []
is_a: MP:0014524 ! abnormal pulmonary alveolar fluid clearance
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:25:04Z" xsd:dateTime

[Term]
id: MP:0014527
name: increased amino acid level
def: "increase in the amount of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [http://purl.obolibrary.org/obo/CHEBI_33709]
synonym: "elevated amino acid level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:53:12Z" xsd:dateTime

[Term]
id: MP:0014528
name: decreased amino acid level
def: "reduction in the amount of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [http://purl.obolibrary.org/obo/CHEBI_33709]
synonym: "reduced amino acid level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:53:25Z" xsd:dateTime

[Term]
id: MP:0014529
name: decreased beta-alanine level
def: "reduction in the amount of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine; it occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins" [GO:0019482]
synonym: "reduced beta-alanine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030729 ! abnormal beta-alanine level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-07T20:58:20Z" xsd:dateTime

[Term]
id: MP:0014530
name: increased circulating amino acid level
def: "increase in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709]
synonym: "elevated circulating amino acid level" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T14:40:52Z" xsd:dateTime

[Term]
id: MP:0014531
name: decreased circulating amino acid level
def: "reduction in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709]
synonym: "reduced circulating amino acid level" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T14:41:10Z" xsd:dateTime

[Term]
id: MP:0014532
name: decreased circulating glutathione level
def: "reduction in the amount per unit of blood of glutathione, a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856]
synonym: "reduced circulating glutathione level" EXACT []
is_a: MP:0012604 ! decreased glutathione level
is_a: MP:0030652 ! abnormal circulating glutathione level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T14:50:42Z" xsd:dateTime

[Term]
id: MP:0014533
name: decreased circulating homocitrulline level
def: "reduction in the amount per unit of blood of homocitrulline, an amino acid and a metabolite of ornithine in mammalian metabolism" [https://en.wikipedia.org/wiki/Homocitrulline]
synonym: "reduced circulating homocitrulline level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030744 ! abnormal circulating homocitrulline level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T14:54:47Z" xsd:dateTime

[Term]
id: MP:0014534
name: decreased circulating hydroxyproline level
def: "reduction in the amount per unit of blood of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741]
synonym: "reduced circulating hydroxyproline level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030679 ! decreased hydroxyproline level
is_a: MP:0030680 ! abnormal circulating hydroxyproline level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T15:03:54Z" xsd:dateTime

[Term]
id: MP:0014535
name: increased mineral level
def: "increase in the concentration of any inorganic substance that has importance in body functions" [ISBN:0-683-40008-8]
synonym: "elevated mineral level" EXACT []
is_a: MP:0000192 ! abnormal mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T16:46:34Z" xsd:dateTime

[Term]
id: MP:0014536
name: decreased mineral level
def: "reduction in the concentration of any inorganic substance that has importance in body functions" [ISBN:0-683-40008-8]
synonym: "reduced mineral level" EXACT []
is_a: MP:0000192 ! abnormal mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T16:46:45Z" xsd:dateTime

[Term]
id: MP:0014537
name: increased calcium level
def: "increase in the concentration of calcium in the body or bodily fluids" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated calcium level" EXACT []
is_a: MP:0014535 ! increased mineral level
is_a: MP:0020879 ! abnormal calcium level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T18:54:05Z" xsd:dateTime

[Term]
id: MP:0014538
name: decreased calcium level
def: "reduction in the concentration of calcium in the body or bodily fluids" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced calcium level" EXACT []
is_a: MP:0014536 ! decreased mineral level
is_a: MP:0020879 ! abnormal calcium level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T18:54:18Z" xsd:dateTime

[Term]
id: MP:0014539
name: increased copper level
def: "increase in the concentration in the body of the metallic element atom that has formula Cu, and normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins" [CHEBI:28694]
synonym: "elevated copper level" EXACT []
is_a: MP:0003952 ! abnormal copper level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:02:07Z" xsd:dateTime

[Term]
id: MP:0014540
name: decreased copper level
def: "reduction in the concentration in the body of the metallic element atom that has formula Cu, and normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins" [CHEBI:28694]
synonym: "reduced copper level" EXACT []
is_a: MP:0003952 ! abnormal copper level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:02:20Z" xsd:dateTime

[Term]
id: MP:0014541
name: increased iron level
def: "increase in the concentrations of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins and is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [ISBN:0-683-40008-8]
synonym: "elevated iron level" EXACT []
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0014535 ! increased mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:22:13Z" xsd:dateTime

[Term]
id: MP:0014542
name: decreased iron level
def: "reduction in the concentrations of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins and is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [ISBN:0-683-40008-8]
synonym: "reduced iron level" EXACT []
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0014536 ! decreased mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:22:28Z" xsd:dateTime

[Term]
id: MP:0014543
name: increased manganese level
def: "increase in the concentration of manganese in the body" [CHEBI:25154]
synonym: "elevated manganese level" EXACT []
is_a: MP:0014535 ! increased mineral level
is_a: MP:0030593 ! abnormal manganese level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:35:55Z" xsd:dateTime

[Term]
id: MP:0014544
name: decreased manganese level
def: "reduction in the concentration of manganese in the body" [CHEBI:25154]
synonym: "reduced manganese level" EXACT []
is_a: MP:0014536 ! decreased mineral level
is_a: MP:0030593 ! abnormal manganese level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:36:08Z" xsd:dateTime

[Term]
id: MP:0014545
name: increased phosphate level
def: "increase in the concentration of phosphate (salt or ester of phosphoric acid) in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated phosphate level" EXACT []
is_a: MP:0014535 ! increased mineral level
is_a: MP:0020885 ! abnormal phosphate level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:45:01Z" xsd:dateTime

[Term]
id: MP:0014546
name: decreased phosphate level
def: "reduction in the concentration of phosphate (salt or ester of phosphoric acid) in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced phosphate level" EXACT []
is_a: MP:0014536 ! decreased mineral level
is_a: MP:0020885 ! abnormal phosphate level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T19:45:17Z" xsd:dateTime

[Term]
id: MP:0014547
name: increased circulating mineral level
def: "increase in the concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0014535 ! increased mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T20:25:14Z" xsd:dateTime

[Term]
id: MP:0014548
name: decreased circulating mineral level
def: "reduction in the concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating mineral level" EXACT []
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0014536 ! decreased mineral level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T20:25:32Z" xsd:dateTime

[Term]
id: MP:0014549
name: increased zinc level
def: "increase in the concentration of zinc in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated zinc level" EXACT []
is_a: MP:0020893 ! abnormal zinc level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T20:34:28Z" xsd:dateTime

[Term]
id: MP:0014550
name: decreased zinc level
def: "reduction in the concentration of zinc in the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced zinc level" EXACT []
is_a: MP:0020893 ! abnormal zinc level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-08-08T20:34:38Z" xsd:dateTime

[Term]
id: MP:0014551
name: impaired neuronal migration
def: "reduced ability or inability of immature neurons to move from germinal zones to specific positions where they will reside as they mature" [http://purl.obolibrary.org/obo/GO_0001764]
is_a: MP:0006009 ! abnormal neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T13:43:59Z" xsd:dateTime

[Term]
id: MP:0014552
name: enhanced neuronal migration
def: "increased ability of immature neurons to move from germinal zones to specific positions where they will reside as they mature" [http://purl.obolibrary.org/obo/GO_0001764]
is_a: MP:0006009 ! abnormal neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T13:44:14Z" xsd:dateTime

[Term]
id: MP:0014553
name: decreased neuronal migration
def: "reduced rate of the movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [http://purl.obolibrary.org/obo/GO_0001764]
synonym: "reduced neuronal migration" EXACT []
is_a: MP:0014551 ! impaired neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:03:04Z" xsd:dateTime

[Term]
id: MP:0014554
name: delayed neuronal migration
def: "late onset of the initiation and/or completion of the movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [http://purl.obolibrary.org/obo/GO_0001764]
is_a: MP:0014551 ! impaired neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:03:18Z" xsd:dateTime

[Term]
id: MP:0014555
name: impaired neuronal migration orientation
def: "immature neurons move from germinal zones to incorrect positions rather than the normal position" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014551 ! impaired neuronal migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:13:40Z" xsd:dateTime

[Term]
id: MP:0014556
name: abnormal cortical ventricular zone thickness
def: "any anomaly in the depth or width of the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal VZ thickness" EXACT []
is_a: MP:0008458 ! abnormal cortical ventricular zone morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:38:57Z" xsd:dateTime

[Term]
id: MP:0014557
name: increased cortical ventricular zone thickness
def: "increase in the depth or width of the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased VZ thickness" EXACT []
synonym: "thick cortical ventricular zone" EXACT []
is_a: MP:0014556 ! abnormal cortical ventricular zone thickness
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:39:19Z" xsd:dateTime

[Term]
id: MP:0014558
name: decreased cortical ventricular zone thickness
def: "decrease in the depth or width of the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced VZ thickness" EXACT []
synonym: "thin cortical ventricular zone" EXACT []
is_a: MP:0014556 ! abnormal cortical ventricular zone thickness
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:39:28Z" xsd:dateTime

[Term]
id: MP:0014559
name: abnormal cortical ventricular zone cell density
def: "any anomaly in the density of cells in the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal VZ cell density" EXACT []
is_a: MP:0008458 ! abnormal cortical ventricular zone morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:43:44Z" xsd:dateTime

[Term]
id: MP:0014560
name: increased cortical ventricular zone cell density
def: "increase in the density of cells in the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased VZ cell density" EXACT []
is_a: MP:0014559 ! abnormal cortical ventricular zone cell density
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:44:14Z" xsd:dateTime

[Term]
id: MP:0014561
name: decreased cortical ventricular zone cell density
def: "reduction in the density of cells in the cortical ventricular zone" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced cortical venrticular zone cell density" EXACT []
synonym: "reduced VZ cell density" EXACT []
is_a: MP:0014559 ! abnormal cortical ventricular zone cell density
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T14:44:23Z" xsd:dateTime

[Term]
id: MP:0014562
name: increased tympanic ring size
def: "larger than average tympanic ring" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000030 ! abnormal tympanic ring morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T15:27:30Z" xsd:dateTime

[Term]
id: MP:0014563
name: duplicated tympanic ring
def: "presence of an additional tympanic ring in one or both ears" [PMID:16221728]
is_a: MP:0000030 ! abnormal tympanic ring morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-09-18T15:29:41Z" xsd:dateTime

[Term]
id: MP:0014564
name: abnormal circulating secretin level
def: "any anomaly in the blood concentration of this polypeptide hormone, originally detected in the proximal small intestine but also expressed in the central nervous system, that regulates gastric acid secretion, water homeostasis throughout the body, and has a role in synaptic function" [https://orcid.org/0000-0001-6624-9261, PMID:18534766]
synonym: "abnormal blood secretin amount" EXACT []
synonym: "abnormal circulating SCT concentration" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T14:59:37Z" xsd:dateTime

[Term]
id: MP:0014565
name: increased circulating secretin level
def: "greater than the normal blood concentration of this polypeptide hormone, originally detected in the proximal small intestine but also expressed in the central nervous system, that regulates gastric acid secretion, water homeostasis throughout the body, and has a role in synaptic function" [PMID:18534766]
synonym: "elevated secretin blood concentration" EXACT []
synonym: "increased blood SCT amount" EXACT []
is_a: MP:0014564 ! abnormal circulating secretin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T15:38:33Z" xsd:dateTime

[Term]
id: MP:0014566
name: decreased circulating secretin level
def: "less than the normal blood concentration of this polypeptide hormone, originally detected in the proximal small intestine but also expressed in the central nervous system, that regulates gastric acid secretion, water homeostasis throughout the body, and has a role in synaptic function" [PMID:18534766]
synonym: "reduced blood SCT amount" EXACT []
synonym: "reduced secretin blood concentration" EXACT []
is_a: MP:0014564 ! abnormal circulating secretin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T15:38:55Z" xsd:dateTime

[Term]
id: MP:0014567
name: increased circulating pancreatic peptide level
def: "greater than the expected amount in the blood of the 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8]
synonym: "elevated circulating PPY amount" EXACT []
is_a: MP:0008459 ! abnormal circulating pancreatic peptide level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T18:00:43Z" xsd:dateTime

[Term]
id: MP:0014568
name: decreased circulating pancreatic peptide level
def: "less than the expected amount in the blood of the 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8]
synonym: "reduced blood PPY amount" EXACT []
is_a: MP:0008459 ! abnormal circulating pancreatic peptide level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T18:00:53Z" xsd:dateTime

[Term]
id: MP:0014569
name: abnormal circulating peptide YY level
def: "any anomaly in the blood concentration of this peptide hormone, produced in the gut and pancreas, that plays a role in the regulation of glucose and energy homeostasis" [https://orcid.org/0000-0001-6624-9261, PMID:26125465]
synonym: "abnormal blood peptide YY (tyrosine tyrosine) amount" EXACT []
synonym: "abnormal circulating PYY concentration" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T18:08:53Z" xsd:dateTime

[Term]
id: MP:0014570
name: increased circulating peptide YY level
def: "greater than the expected amount in the blood of this peptide hormone, produced in the gut and pancreas, that plays a role in the regulation of glucose and energy homeostasis" [PMID:26125465]
synonym: "elevated blood PYY amount" EXACT []
synonym: "increased circulating PYY concentration" EXACT []
is_a: MP:0014569 ! abnormal circulating peptide YY level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T18:36:12Z" xsd:dateTime

[Term]
id: MP:0014571
name: decreased circulating peptide YY level
def: "less than the expected amount in the blood of this peptide hormone, produced in the gut and pancreas, that plays a role in the regulation of glucose and energy homeostasis" []
synonym: "decreased circulating PYY concentration" EXACT []
synonym: "reduced blood PYY amount" EXACT []
xref: PMID:26125465
is_a: MP:0014569 ! abnormal circulating peptide YY level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T18:36:24Z" xsd:dateTime

[Term]
id: MP:0014572
name: abnormal circulating resistin level
def: "any anomaly in the blood concentration of this cysteine-rich peptide hormone, derived from adipose tissue, that is implicated in the modulation of insulin activity, energy, glucose, and lipid homeostasis" [https://orcid.org/0000-0001-6624-9261]
synonym: "abnormal blood resistin amount" EXACT []
synonym: "abnormal circulating RETN concentration" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T19:00:47Z" xsd:dateTime

[Term]
id: MP:0014573
name: increased circulating resistin level
def: "greater than the expected blood concentration of this cysteine-rich peptide hormone, derived from adipose tissue, that is implicated in the modulation of insulin activity, energy, glucose, and lipid homeostasis" [https://orcid.org/0000-0001-6624-9261]
synonym: "elevated blood resistin amount" EXACT []
synonym: "increased circulating RETN concentration" EXACT []
is_a: MP:0014572 ! abnormal circulating resistin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T19:07:21Z" xsd:dateTime

[Term]
id: MP:0014574
name: decreased circulating resistin level
def: "less than the expected blood concentration of this cysteine-rich peptide hormone, derived from adipose tissue, that is implicated in the modulation of insulin activity, energy, glucose, and lipid homeostasis" [https://orcid.org/0000-0001-6624-9261]
synonym: "decreased circulating RETN concentration" EXACT []
synonym: "reduced blood resistin amount" EXACT []
is_a: MP:0014572 ! abnormal circulating resistin level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-16T19:07:29Z" xsd:dateTime

[Term]
id: MP:0014575
name: increased intestinal transit time
def: "greater than the expected time for a bolus of material to pass through the intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006001 ! abnormal intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:12:34Z" xsd:dateTime

[Term]
id: MP:0014576
name: decreased intestinal transit time
def: "less than the expected time for a bolus of material to pass through the intestine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced intestinal transit time" EXACT []
is_a: MP:0006001 ! abnormal intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:12:50Z" xsd:dateTime

[Term]
id: MP:0014577
name: increased large intestinal transit time
def: "greater than the expected time for a bolus of material to pass through the large intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006003 ! abnormal large intestinal transit time
is_a: MP:0014575 ! increased intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:14:00Z" xsd:dateTime

[Term]
id: MP:0014578
name: increased small intestinal transit time
def: "greater than the expected time for a bolus of material to pass through the small intestine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006002 ! abnormal small intestinal transit time
is_a: MP:0014575 ! increased intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:14:13Z" xsd:dateTime

[Term]
id: MP:0014579
name: decreased large intestinal transit time
def: "less than the expected time for a bolus of material to pass through the large intestine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced large intestinal transit time" EXACT []
is_a: MP:0006003 ! abnormal large intestinal transit time
is_a: MP:0014576 ! decreased intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:14:35Z" xsd:dateTime

[Term]
id: MP:0014580
name: decreased small intestinal transit time
def: "less than the expected time for a bolus of material to pass through the small intestine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced small intestinal transit time" EXACT []
is_a: MP:0006002 ! abnormal small intestinal transit time
is_a: MP:0014576 ! decreased intestinal transit time
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-10-17T18:14:47Z" xsd:dateTime

[Term]
id: MP:0014581
name: abnormal circulating gastric inhibitory polypeptide level
def: "any anomaly in the concentration in the blood of this incretin secreted from enteroendocrine K cells in response to glucose and fat ingestion that enhances glucose-dependent insulin secretion" [https://orcid.org/0000-0001-6624-9261, PMID:31977316]
synonym: "abnormal circulating GIP amount" EXACT []
synonym: "abnormal circulating GIP concentration" EXACT []
synonym: "abnormal circulating glucose-dependent insulinotropic polypeptide level" EXACT []
is_a: MP:0005418 ! abnormal circulating hormone level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T16:16:28Z" xsd:dateTime

[Term]
id: MP:0014582
name: increased circulating gastric inhibitory polypeptide level
def: "increase in the concentration in the blood of this incretin secreted from enteroendocrine K cells in response to glucose and fat ingestion that enhances glucose-dependent insulin secretion" [PMID:31977316]
synonym: "elevated circulating GIP concentration" EXACT []
synonym: "increased circulating GIP amount" EXACT []
synonym: "increased circulating glucose-dependent insulinotropic polypeptide level" EXACT []
is_a: MP:0014456 ! increased circulating hormone level
is_a: MP:0014581 ! abnormal circulating gastric inhibitory polypeptide level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T16:17:20Z" xsd:dateTime

[Term]
id: MP:0014583
name: decreased circulating gastric inhibitory polypeptide level
def: "reduction in the concentration in the blood of this incretin secreted from enteroendocrine K cells in response to glucose and fat ingestion that enhances glucose-dependent insulin secretion" [PMID:31977316]
synonym: "decreased circulating GIP amount" EXACT []
synonym: "decreased circulating glucose-dependent insulinotropic polypeptide level" EXACT []
synonym: "reduced circulating GIP concentration" EXACT []
is_a: MP:0014457 ! decreased circulating hormone level
is_a: MP:0014581 ! abnormal circulating gastric inhibitory polypeptide level
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T16:17:30Z" xsd:dateTime

[Term]
id: MP:0014584
name: abnormal egg cylinder size
def: "anomaly in the average size of the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003085 ! abnormal egg cylinder morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T19:07:23Z" xsd:dateTime

[Term]
id: MP:0014585
name: increased egg cylinder size
def: "increase in the average size of the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014584 ! abnormal egg cylinder size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T19:18:49Z" xsd:dateTime

[Term]
id: MP:0014586
name: decreased egg cylinder size
def: "reduction in the average size of the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced egg cylinder size" EXACT []
synonym: "rudimentary egg cylinder" NARROW [https://orcid.org/0000-0002-6490-7723]
synonym: "small egg cylinder" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014584 ! abnormal egg cylinder size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-05T19:18:58Z" xsd:dateTime

[Term]
id: MP:0014587
name: impaired fine motor coordination
def: "reduced ability to coordinate movement of small muscle groups" [NBO:0000348]
is_a: MP:0001405 ! impaired coordination
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-07T21:09:17Z" xsd:dateTime

[Term]
id: MP:0014588
name: impaired gross motor coordination
def: "reduced ability to coordinate movement of large muscle groups or the whole body" [http://purl.obolibrary.org/obo/NBO_0000347]
is_a: MP:0001405 ! impaired coordination
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-07T21:09:35Z" xsd:dateTime

[Term]
id: MP:0014589
name: abnormal gonadotropin-releasing hormone neuron morphology
def: "any structural anomaly of the neuroendocrine cell that secretes gonadotropin-releasing hormone (GnRH)" [] {comment="CL:0011111"}
synonym: "abnormal GnRH neuron morphology" EXACT []
synonym: "abnormal GnRH-secreting neuron morphology" EXACT []
is_a: MP:0010913 ! abnormal neuroendocrine cell morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-12T19:47:27Z" xsd:dateTime

[Term]
id: MP:0014590
name: abnormal gonadotropin-releasing hormone neuron number
def: "any anomaly in the number of the neuroendocrine cells that secrete gonadotropin-releasing hormone" []
synonym: "abnormal GnRH neuron count" EXACT []
synonym: "abnormal GnRH-secreting neuron count" EXACT []
is_a: MP:0014589 ! abnormal gonadotropin-releasing hormone neuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-12T19:54:22Z" xsd:dateTime

[Term]
id: MP:0014591
name: increased gonadotropin-releasing hormone neuron number
def: "increase in the number of the neuroendocrine cells that secrete gonadotropin-releasing hormone" []
synonym: "increased GnRH neuron count" EXACT []
synonym: "increased GnRH-secreting neuron count" EXACT []
is_a: MP:0014590 ! abnormal gonadotropin-releasing hormone neuron number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-12T19:57:00Z" xsd:dateTime

[Term]
id: MP:0014592
name: decreased gonadotropin-releasing hormone neuron number
def: "reduction in the number of the neuroendocrine cells that secrete gonadotropin-releasing hormone" []
synonym: "decreased GnRH neuron count" EXACT []
synonym: "decreased GnRH-secreting neuron count" EXACT []
is_a: MP:0014590 ! abnormal gonadotropin-releasing hormone neuron number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-12T19:57:10Z" xsd:dateTime

[Term]
id: MP:0014593
name: absent gonadotropin-releasing hormone neuron
def: "absence of the neuroendocrine cells that secrete gonadotropin-releasing hormone" []
synonym: "absent GnRH neuron" EXACT []
synonym: "absent GnRH-secreting neurons" EXACT []
is_a: MP:0014592 ! decreased gonadotropin-releasing hormone neuron number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-11-12T19:57:27Z" xsd:dateTime

[Term]
id: MP:0014594
name: abnormal sperm cytoplasmic droplet morphology
def: "any structural anomaly in the small amount of cytoplasm surrounded by a cell membrane that may be retained in the spermatozoa after spermiogenesis" [http://purl.obolibrary.org/obo/GO_0097598]
comment: Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted. {xref="GO:0097598"}
synonym: "abnormal sperm residual cytoplasm morphology" EXACT []
is_a: MP:0006362 ! abnormal male germ cell morphology
is_a: MP:0014239 ! abnormal intracellular organelle morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-12-18T20:34:15Z" xsd:dateTime

[Term]
id: MP:0014595
name: abnormal sperm cytoplasmic droplet number
def: "any anomaly in the number of sperm cytoplasmic droplets" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal sperm residual cytoplasm number" EXACT []
is_a: MP:0014594 ! abnormal sperm cytoplasmic droplet morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-12-18T20:42:11Z" xsd:dateTime

[Term]
id: MP:0014596
name: increased sperm cytoplasmic droplet number
def: "increase in the number of sperm cytoplasmic droplets" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased sperm residual cytoplasm count" EXACT []
is_a: MP:0014595 ! abnormal sperm cytoplasmic droplet number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-12-18T20:42:28Z" xsd:dateTime

[Term]
id: MP:0014597
name: decreased sperm cytoplasmic droplet number
def: "reduction in the number of sperm cytoplasmic droplets" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced sperm residual cytoplasm count" EXACT []
is_a: MP:0014595 ! abnormal sperm cytoplasmic droplet number
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-12-18T20:42:38Z" xsd:dateTime

[Term]
id: MP:0014598
name: abnormal sperm cytoplasmic droplet placement
def: "any anomaly in the location of the cytoplasmic within the sperm; location of the droplet changes during maturation migrating from the neck behind the head of an elongated spermatid to the annulus at the end of the midpiece" [http://purl.obolibrary.org/obo/GO_0097598]
synonym: "abnormal sperm residual cytoplasm placement" EXACT []
is_a: MP:0014594 ! abnormal sperm cytoplasmic droplet morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2024-12-18T20:49:16Z" xsd:dateTime

[Term]
id: MP:0014599
name: decreased susceptibility to hyperoxia-induced injury
def: "a diminished likelihood or extent of damage to cells, tissues, or entire organsim following exposure to toxic levels of oxygen" [PMID:37553579]
synonym: "reduced susceptibility to hyperoxia-induced injury" EXACT []
is_a: MP:0005166 ! decreased susceptibility to injury
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0009-0005-7755-8314
property_value: terms:date "2025-01-14T15:43:41Z" xsd:dateTime

[Term]
id: MP:0014600
name: increased susceptibility to hyperoxia-induced injury
def: "an increased likelihood or extent of damage to cells, tissues, or entire organsim following exposure to toxic levels of oxygen" [PMID:37553579]
is_a: MP:0005165 ! increased susceptibility to injury
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0009-0005-7755-8314
property_value: terms:date "2025-01-14T15:43:56Z" xsd:dateTime

[Term]
id: MP:0014601
name: decreased mating frequency
def: "decreased number of attempts of sexual behavioral contact between an initiating organism and a receptive partner" [MESH:F01.145.113.252.748.200]
synonym: "reduced mating frequency" EXACT []
is_a: MP:0001377 ! abnormal mating frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T16:48:58Z" xsd:dateTime

[Term]
id: MP:0014602
name: decreased female mating frequency
def: "females do not as frequently engage in sexual behavior" [PMID:34135859]
synonym: "reduced female mating frequency" EXACT []
is_a: MP:0014601 ! decreased mating frequency
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T16:53:14Z" xsd:dateTime

[Term]
id: MP:0014603
name: neuromuscular synapse degeneration
def: "retrogressive impairment of function or destruction of the membrane to membrane contact of a motor axon and a muscle myofiber that is responsible for the transmission of nerve impulses" [PMID:32934225]
synonym: "neuromuscular junction degeneration" EXACT []
synonym: "NMJ degeneration" EXACT []
is_a: MP:0001053 ! abnormal neuromuscular synapse morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T18:05:53Z" xsd:dateTime

[Term]
id: MP:0014604
name: hemorrhagic ovary cyst
def: "presence of one or more fluid-filled membranous sacs containing blood within the ovary" [HP:0012886, PMID:19684329]
synonym: "hemorrhagic ovarian cysts" EXACT []
is_a: MP:0002016 ! ovary cyst
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T18:28:55Z" xsd:dateTime

[Term]
id: MP:0014605
name: dark liver
def: "liver has a darker color than normal" [PMID:632744]
is_a: MP:0000598 ! abnormal liver morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T18:47:55Z" xsd:dateTime

[Term]
id: MP:0014606
name: dark spleen
def: "spleen has a darker color than normal" [PMID:9028339]
is_a: MP:0000689 ! abnormal spleen morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T18:53:28Z" xsd:dateTime

[Term]
id: MP:0014607
name: decreased reactive oxygen species production
def: "decrease in the production of free radical groups in a cell, tissue or whole body" [GO:1903409]
synonym: "reduced oxidative stress" RELATED []
synonym: "reduced ROS production" EXACT []
is_a: MP:0003186 ! abnormal redox activity
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T21:23:01Z" xsd:dateTime

[Term]
id: MP:0014608
name: abnormal lipid transport
def: "any anomaly in the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore" [http://purl.obolibrary.org/obo/GO_0006869]
is_a: MP:0002118 ! abnormal lipid homeostasis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-14T22:02:43Z" xsd:dateTime

[Term]
id: MP:0014609
name: abnormal bone marrow cavity size
def: "any anomaly in the size of the bone marrow cavity" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal bone medullary cavity size" EXACT []
is_a: MP:0000065 ! abnormal bone marrow cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T19:47:07Z" xsd:dateTime

[Term]
id: MP:0014610
name: increased bone marrow cavity size
def: "larger than the normal physical proportions of one or more bone marrow cavities" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged bone marrow cavity" EXACT []
synonym: "increased bone medullary cavity size" EXACT []
is_a: MP:0014609 ! abnormal bone marrow cavity size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T19:48:00Z" xsd:dateTime

[Term]
id: MP:0014611
name: decreased bone marrow cavity size
def: "smaller than the normal physical proportions of one or more bone marrow cavities" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced bone marrow cavity size" EXACT []
synonym: "reduced bone medullary cavity size" EXACT []
synonym: "small bone marrow cavity" EXACT []
is_a: MP:0014609 ! abnormal bone marrow cavity size
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T19:48:09Z" xsd:dateTime

[Term]
id: MP:0014612
name: absent bone marrow cavity
def: "absence of the medullary cavities of the bones" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent bone medullary cavity" EXACT []
is_a: MP:0000065 ! abnormal bone marrow cavity morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T20:05:48Z" xsd:dateTime

[Term]
id: MP:0014613
name: abnormal bone marrow cavity formation
def: "any anomaly in the formation of the medullary cavities of the bones" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000065 ! abnormal bone marrow cavity morphology
is_a: MP:0002113 ! abnormal skeleton development
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T20:31:37Z" xsd:dateTime

[Term]
id: MP:0014614
name: delayed bone marrow cavity formation
def: "later than expected time for the formation of the bone marrow cavities" [PMID:17194222]
is_a: MP:0014613 ! abnormal bone marrow cavity formation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T20:32:07Z" xsd:dateTime

[Term]
id: MP:0014615
name: premature bone marrow cavity formation
def: "earlier than expected time for the formation of the bone marrow cavities" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014613 ! abnormal bone marrow cavity formation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-15T20:32:17Z" xsd:dateTime

[Term]
id: MP:0014616
name: abnormal spermatogonia number
def: "any anomaly in the numbers of the large unspecialized male germ cells that give rise to spermatocytes" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0006378 ! abnormal spermatogonia morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-27T19:11:49Z" xsd:dateTime

[Term]
id: MP:0014617
name: decreased spermatogonia number
def: "decrease in the numbers of the large unspecialized male germ cells that give rise to spermatocytes" [https://orcid.org/0000-0003-4606-0597, PMID:37781892]
synonym: "reduced spermatogonium count" EXACT []
synonym: "spermatogonia hypoplasia" RELATED []
is_a: MP:0004901 ! decreased male germ cell number
is_a: MP:0014616 ! abnormal spermatogonia number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-27T19:12:15Z" xsd:dateTime

[Term]
id: MP:0014618
name: increased spermatogonia number
def: "increase in the numbers of the large unspecialized male germ cells that give rise to spermatocytes" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased spermatogonium count" EXACT []
is_a: MP:0014616 ! abnormal spermatogonia number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-27T19:12:23Z" xsd:dateTime

[Term]
id: MP:0014619
name: absent spermatogonia
def: "absence of the large unspecialized male germ cells that give rise to spermatocytes" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent spermatogonium" EXACT []
is_a: MP:0014617 ! decreased spermatogonia number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-01-27T20:25:29Z" xsd:dateTime

[Term]
id: MP:0014620
name: abnormal interictal brain wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG) in the time between epileptic seizures" [HP:0025373, PMID:18215623]
synonym: "abnormal interictal EEG pattern" EXACT []
synonym: "abnormal interictal electroencephalogram" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T18:55:06Z" xsd:dateTime

[Term]
id: MP:0014621
name: abnormal brain alpha wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential in the 8-12 or 13 Hz range between parts of the brain, often visualized on an electroencephalogram (EEG)" [https://emedicine.medscape.com/article/1139332-overview?form=fpf, PMID:22119903]
comment: the precise range covered by each band varies slightly depending on species
synonym: "abnormal alpha oscillations" EXACT []
synonym: "abnormal alpha waveform" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T19:55:23Z" xsd:dateTime

[Term]
id: MP:0014622
name: abnormal brain beta wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential in the 12 or 13-30 Hz range between parts of the brain, often visualized on an electroencephalogram (EEG)" [https://emedicine.medscape.com/article/1139332-overview?form=fpf, PMID:22119903]
comment: the precise range covered by each band varies slightly depending on species
synonym: "abnormal beta oscillations" EXACT []
synonym: "abnormal beta waveform" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T19:55:35Z" xsd:dateTime

[Term]
id: MP:0014623
name: abnormal brain theta wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential in the 4-7 or 8 Hz range between parts of the brain, often visualized on an electroencephalogram (EEG)" [https://emedicine.medscape.com/article/1139332-overview?form=fpf, PMID:22119903]
comment: the precise range covered by each band varies slightly depending on species
synonym: "abnormal theta oscillations" EXACT []
synonym: "abnormal theta waveform" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T19:55:51Z" xsd:dateTime

[Term]
id: MP:0014624
name: abnormal brain delta wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential in the 0.5-4 Hz range between parts of the brain, often visualized on an electroencephalogram (EEG)" [https://emedicine.medscape.com/article/1139332-overview?form=fpf, PMID:22119903]
comment: the precise range covered by each band varies slightly depending on species
synonym: "abnormal delta waveform" EXACT []
synonym: "abnormal delte oscillations" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T19:56:05Z" xsd:dateTime

[Term]
id: MP:0014625
name: abnormal ictal brain wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG) in the time during epileptic seizure" [PMID:23922229]
synonym: "abnormal ictal EEG pattern" EXACT []
synonym: "abnormal ictal electroencephalogram" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T20:03:54Z" xsd:dateTime

[Term]
id: MP:0014626
name: abnormal postictal brain wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG) in the time just after epileptic seizures" [PMID:23922229]
synonym: "abnormal postictal EEG pattern" EXACT []
synonym: "abnormal postictal electroencephalogram" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T20:04:07Z" xsd:dateTime

[Term]
id: MP:0014627
name: abnormal preictal brain wave pattern
def: "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG) in the time just before epileptic seizures" [PMID:23922229]
synonym: "abnormal preictal EEG pattern" EXACT []
synonym: "abnormal preictal electroencephalogram" EXACT []
is_a: MP:0004994 ! abnormal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T20:04:19Z" xsd:dateTime

[Term]
id: MP:0014628
name: hypsarrhythmia
def: "the presence of interictal multifocal spike activity over a high voltage chaotic slow wave background" [HP:0002521, PMID:36883084]
is_a: MP:0014620 ! abnormal interictal brain wave pattern
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T20:10:38Z" xsd:dateTime

[Term]
id: MP:0014629
name: hypothalamus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the hypothalamus, typically resulting in increased size" [PMID:8543155]
synonym: "hypoplasia of the hypothalamus" EXACT []
synonym: "hypoplastic hypothalamus" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T20:41:01Z" xsd:dateTime

[Term]
id: MP:0014630
name: abnormal round spermatid morphology
def: "any structural anomaly of spermatids in the early stage of maturation that have a round morphology and are transcriptionally active" [] {comment="CL:4030036"}
synonym: "abnormal early spermatid morphology" EXACT []
is_a: MP:0006380 ! abnormal spermatid morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:07:04Z" xsd:dateTime

[Term]
id: MP:0014631
name: abnormal elongated spermatid morphology
def: "any structural anomaly of spermatids with an elongated morphology that are transcriptionally inert when the acrosome is fully developed" [] {comment="CL:4030037"}
synonym: "abnormal late spermatid morphology" EXACT []
is_a: MP:0006380 ! abnormal spermatid morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:07:21Z" xsd:dateTime

[Term]
id: MP:0014632
name: increased spermatid number
def: "greater number of spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated spermatid numbers" EXACT []
is_a: MP:0006380 ! abnormal spermatid morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:14:47Z" xsd:dateTime

[Term]
id: MP:0014633
name: decreased spermatid number
def: "reduced numbers of spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced spermatid numbers" EXACT []
is_a: MP:0004901 ! decreased male germ cell number
is_a: MP:0006380 ! abnormal spermatid morphology
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:15:01Z" xsd:dateTime

[Term]
id: MP:0014634
name: decreased round spermatid number
def: "reduced numbers of round spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced early spermatid numbers" EXACT []
is_a: MP:0014630 ! abnormal round spermatid morphology
is_a: MP:0014633 ! decreased spermatid number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:35:39Z" xsd:dateTime

[Term]
id: MP:0014635
name: increased round spermatid number
def: "elevated numbers of round spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated early spermatid numbers" EXACT []
is_a: MP:0014630 ! abnormal round spermatid morphology
is_a: MP:0014632 ! increased spermatid number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:35:53Z" xsd:dateTime

[Term]
id: MP:0014636
name: decreased elongated spermatid number
def: "reduced numbers of elongated spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced late spermatid numbers" EXACT []
is_a: MP:0014631 ! abnormal elongated spermatid morphology
is_a: MP:0014633 ! decreased spermatid number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:36:11Z" xsd:dateTime

[Term]
id: MP:0014637
name: increased elongated spermatid number
def: "elevated numbers of elongated spermatids" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated late spermatid numbers" EXACT []
is_a: MP:0014631 ! abnormal elongated spermatid morphology
is_a: MP:0014632 ! increased spermatid number
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-14T21:36:20Z" xsd:dateTime

[Term]
id: MP:0014638
name: increased sleep duration
def: "increase in the amount of time spent asleep in a defined period of time" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0021198 ! abnormal sleep duration
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-17T21:19:04Z" xsd:dateTime

[Term]
id: MP:0014639
name: decreased sleep duration
def: "reduction the amount of time spent asleep in a defined period of time" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced sleep duration" EXACT []
is_a: MP:0021198 ! abnormal sleep duration
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-17T21:19:16Z" xsd:dateTime

[Term]
id: MP:0014640
name: abnormal horizontal optokinetic reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the horizontal (left-right) plane" [PMID:6969184]
synonym: "abnormal HOKR" EXACT []
is_a: MP:0009619 ! abnormal optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T18:39:00Z" xsd:dateTime

[Term]
id: MP:0014641
name: abnormal vertical optokinetic reflex
def: "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the vertical (up-down) plane" [PMID:12939299]
synonym: "abnormal VOKR" EXACT []
is_a: MP:0009619 ! abnormal optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T18:39:13Z" xsd:dateTime

[Term]
id: MP:0014642
name: increased optokinetic reflex
def: "increase in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement" [PMID:25995483]
synonym: "increased OKR" EXACT []
is_a: MP:0009619 ! abnormal optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:26:36Z" xsd:dateTime

[Term]
id: MP:0014643
name: increased vertical optokinetic reflex
def: "increase in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the vertical (up-down) plane" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased VOKR" EXACT []
is_a: MP:0014641 ! abnormal vertical optokinetic reflex
is_a: MP:0014642 ! increased optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:26:48Z" xsd:dateTime

[Term]
id: MP:0014644
name: increased horizontal optokinetic reflex
def: "increase in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the horizontal (left-right) plane" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased HOKR" EXACT []
is_a: MP:0014640 ! abnormal horizontal optokinetic reflex
is_a: MP:0014642 ! increased optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:27:05Z" xsd:dateTime

[Term]
id: MP:0014645
name: decreased optokinetic reflex
def: "decrease in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement" [PMID:23301081]
synonym: "decreased OKR" EXACT []
is_a: MP:0009619 ! abnormal optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:27:27Z" xsd:dateTime

[Term]
id: MP:0014646
name: decreased vertical optokinetic reflex
def: "decrease in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the vertical (up-down) plane" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased VOKR" EXACT []
is_a: MP:0014641 ! abnormal vertical optokinetic reflex
is_a: MP:0014645 ! decreased optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:27:37Z" xsd:dateTime

[Term]
id: MP:0014647
name: decreased horizontal optokinetic reflex
def: "decrease in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement in the horizontal (left-right) plane" [PMID:17344385]
synonym: "decreased HOKR" EXACT []
is_a: MP:0014640 ! abnormal horizontal optokinetic reflex
is_a: MP:0014645 ! decreased optokinetic reflex
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T19:27:48Z" xsd:dateTime

[Term]
id: MP:0014648
name: abnormal response to nerve crush injury
def: "any anomaly in the response of a nerve or nerves to compression induced injury" [PMID:17409231]
is_a: MP:0003633 ! abnormal nervous system physiology
is_a: MP:0005164 ! abnormal response to injury
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T21:06:54Z" xsd:dateTime

[Term]
id: MP:0014649
name: increased susceptibility to nerve crush injury
def: "more severe response of a nerve or nerves to compression injury" [PMID:17409231]
is_a: MP:0014648 ! abnormal response to nerve crush injury
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T21:10:44Z" xsd:dateTime

[Term]
id: MP:0014650
name: decreased susceptibility to nerve crush injury
def: "less severe response of a nerve or nerves to compression injury" [PMID:17409231]
is_a: MP:0014648 ! abnormal response to nerve crush injury
property_value: terms1:contributor https://orcid.org/0000-0003-4606-0597
property_value: terms:date "2025-02-18T21:10:53Z" xsd:dateTime

[Term]
id: MP:0020000
name: abnormal response to antigen
def: "anomaly in the immune response after exposure to an antigen" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001790 ! abnormal immune system physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020001
name: decreased response to antigen
def: "decreased or weak immune response after exposure to an antigen" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020000 ! abnormal response to antigen
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020002
name: increased response to antigen
def: "increased immune response after exposure to an antigen" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020000 ! abnormal response to antigen
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020003
name: abnormal sulfolipid level
def: "an anomaly in the concentration of lipids that possess a sulfur-containing functional group" [http://en.wikipedia.org/wiki/Sulfolipid, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020004
name: obsolete abnormal sulfatide level
def: "anomaly in the concentration of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide, https://orcid.org/0000-0001-5208-3432]
comment: obsoleting term because it is a duplicate
synonym: "abnormal sulphatide level" EXACT []
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0012229
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020005
name: decreased sulfoglycosphingolipid level
def: "decreased concentration or amount of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased sulfatide level" EXACT []
synonym: "decreased sulphatide level" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0012229 ! abnormal sulfoglycosphingolipid level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020006
name: increased sulfoglycosphingolipid level
def: "increased concentration or amount of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide, https://orcid.org/0000-0001-5208-3432]
synonym: "increased sulfatide level" EXACT []
synonym: "increased sulphatide level" EXACT []
is_a: MP:0012229 ! abnormal sulfoglycosphingolipid level
is_a: MP:0014460 ! increased lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020007
name: decreased brain sulfoglycosphingolipid level
def: "decreased brain concentration of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased brain sulfatide level" EXACT []
synonym: "decreased brain sulphatide level" EXACT []
is_a: MP:0020005 ! decreased sulfoglycosphingolipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020008
name: increased brain sulfoglycosphingolipid level
def: "increased brain concentration of the sulfolipids that contribute to myelin function and stability" [http://en.wikipedia.org/wiki/sulfatide, https://orcid.org/0000-0001-5208-3432]
synonym: "increased brain sulfatide level" EXACT []
synonym: "increased brain sulphatide level" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0020006 ! increased sulfoglycosphingolipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020009
name: abnormal bone mineral density of femur
def: "anomaly in the quantitative measurment of mineral content of bone in the long bone of the thigh" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal BMD of femur" EXACT []
synonym: "abnormal femur bone mineral density" EXACT []
is_a: MP:0010119 ! abnormal bone mineral density
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020010
name: decreased bone mineral density of femur
def: "reduction in the quantitative measurment value of mineral content of bone in the long bone of the thigh" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased BMD of femur" EXACT []
synonym: "decreased femur bone mineral density" EXACT []
is_a: MP:0000063 ! decreased bone mineral density
is_a: MP:0020009 ! abnormal bone mineral density of femur
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020011
name: increased bone mineral density of femur
def: "elevation in the quantitative measurement value of mineral content of bone in the long bone of the thigh" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased BMD of femur" EXACT []
synonym: "increased femur bone mineral density" EXACT []
is_a: MP:0000062 ! increased bone mineral density
is_a: MP:0020009 ! abnormal bone mineral density of femur
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020012
name: abnormal arylsulphatase activity
def: "anomaly in the ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate" [http://enzyme.expasy.org/EC/3.1.6.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020013
name: decreased arylsulphatase activity
def: "decreased ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate" [http://enzyme.expasy.org/EC/3.1.6.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020012 ! abnormal arylsulphatase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020014
name: increased arylsulphatase activity
def: "increased ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate" [http://enzyme.expasy.org/EC/3.1.6.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020012 ! abnormal arylsulphatase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020015
name: abnormal aldehyde dehydrogenase activity
def: "anomaly in the ability to catalyze the oxidation (dehydrogenation) of aldehydes." [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020016
name: decreased aldehyde dehydrogenase activity
def: "increased ability to catalyze the oxidation (dehydrogenation) of aldehydes." [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020015 ! abnormal aldehyde dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020017
name: increased aldehyde dehydrogenase activity
def: "decreased ability to catalyze the oxidation (dehydrogenation) of aldehydes." [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020015 ! abnormal aldehyde dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020018
name: abnormal phenylalanine decarboxylase activity
def: "anomaly in the ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal aromatic L-amino acid decarboxylase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020019
name: decreased phenylalanine decarboxylase activity
def: "decreased ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased aromatic L-amino acid decarboxylase activity" EXACT []
is_a: MP:0020018 ! abnormal phenylalanine decarboxylase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020020
name: increased phenylalanine decarboxylase activity
def: "increased ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
synonym: "increased aromatic L-amino acid decarboxylase activity" EXACT []
is_a: MP:0020018 ! abnormal phenylalanine decarboxylase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020021
name: abnormal delta-aminolaevulinate dehydratase activity
def: "anomaly in the ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen" [http://enzyme.expasy.org/EC/4.2.1.24, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal porphobilinogen synthase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020022
name: decreased delta-aminolaevulinate dehydratase activity
def: "decreased ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen" [http://enzyme.expasy.org/EC/4.2.1.24, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased porphobilinogen synthase activity" EXACT []
is_a: MP:0020021 ! abnormal delta-aminolaevulinate dehydratase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020023
name: decreased hepatic delta-aminolaevulinate dehydratase activity
def: "decreased ability to catalyze the reaction in the liver: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen" [http://enzyme.expasy.org/EC/4.2.1.24, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased hepatic porphobilinogen synthase activity" EXACT []
is_a: MP:0020022 ! decreased delta-aminolaevulinate dehydratase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020024
name: increased delta-aminolaevulinate dehydratase activity
def: "increased ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen" [http://enzyme.expasy.org/EC/4.2.1.24, https://orcid.org/0000-0001-5208-3432]
synonym: "increased porphobilinogen synthase activity" EXACT []
is_a: MP:0020021 ! abnormal delta-aminolaevulinate dehydratase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020025
name: increased hepatic delta-aminolaevulinate dehydratase activity
def: "increased ability to catalyze the reaction in the liver: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen" [http://enzyme.expasy.org/EC/4.2.1.24, https://orcid.org/0000-0001-5208-3432]
synonym: "increased hepatic porphobilinogen synthase activity" EXACT []
is_a: MP:0020024 ! increased delta-aminolaevulinate dehydratase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020026
name: abnormal aldehyde oxidase activity
def: "anomaly in the ability to catalyze the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide" [http://enzyme.expasy.org/EC/1.2.3.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020027
name: decreased aldehyde oxidase activity
def: "decreased ability to catalyze the reaction:an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide" [http://enzyme.expasy.org/EC/1.2.3.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020026 ! abnormal aldehyde oxidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020028
name: increased aldehyde oxidase activity
def: "increased ability to catalyze the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide" [http://enzyme.expasy.org/EC/1.2.3.1, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020026 ! abnormal aldehyde oxidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-22T00:00:00Z

[Term]
id: MP:0020029
name: abnormal cholinesterase activity
def: "aberrant activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal acylcholine acylhydrolase activity" EXACT []
synonym: "abnormal anticholineesterase activity" EXACT []
synonym: "abnormal benzoylcholinesterase activity" EXACT []
synonym: "abnormal BtChoEase activity" EXACT []
synonym: "abnormal butyrylcholine esterase activity" EXACT []
synonym: "abnormal butyrylcholinesterase activity" EXACT []
synonym: "abnormal choline esterase activity" EXACT []
synonym: "abnormal choline esterase II (unspecific) activity" EXACT []
synonym: "abnormal non-specific cholinesterase activity" EXACT []
synonym: "abnormal propionylcholinesterase activity" EXACT []
synonym: "abnormal pseudocholinesterase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020030
name: abnormal circulating cholinesterase activity
def: "aberrant activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal circulating acylcholine acylhydrolase activity" EXACT []
synonym: "abnormal circulating anticholineesterase activity" EXACT []
synonym: "abnormal circulating benzoylcholinesterase activity" EXACT []
synonym: "abnormal circulating BtChoEase activity" EXACT []
synonym: "abnormal circulating butyrylcholine esterase activity" EXACT []
synonym: "abnormal circulating butyrylcholinesterase activity" EXACT []
synonym: "abnormal circulating choline esterase activity" EXACT []
synonym: "abnormal circulating choline esterase II (unspecific) activity" EXACT []
synonym: "abnormal circulating non-specific cholinesterase activity" EXACT []
synonym: "abnormal circulating propionylcholinesterase activity" EXACT []
synonym: "abnormal circulating pseudocholinesterase activity" EXACT []
is_a: MP:0020029 ! abnormal cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020031
name: decreased circulating cholinesterase activity
def: "decreased activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased plasma cholinesterase activity" NARROW []
is_a: MP:0020030 ! abnormal circulating cholinesterase activity
is_a: MP:0020034 ! decreased cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020032
name: increased circulating cholinesterase activity
def: "increased activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "increased plasma cholinesterase activity" NARROW []
is_a: MP:0020030 ! abnormal circulating cholinesterase activity
is_a: MP:0020033 ! increased cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020033
name: increased cholinesterase activity
def: "increased activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "increased acylcholine acylhydrolase activity" EXACT []
synonym: "increased anticholineesterase activity" EXACT []
synonym: "increased benzoylcholinesterase activity" EXACT []
synonym: "increased BtChoEase activity" EXACT []
synonym: "increased butyrylcholine esterase activity" EXACT []
synonym: "increased butyrylcholinesterase activity" EXACT []
synonym: "increased choline esterase activity" EXACT []
synonym: "increased choline esterase II (unspecific) activity" EXACT []
synonym: "increased non-specific cholinesterase activity" EXACT []
synonym: "increased propionylcholinesterase activity" EXACT []
synonym: "increased pseudocholinesterase activity" EXACT []
is_a: MP:0020029 ! abnormal cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020034
name: decreased cholinesterase activity
def: "decreased activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid" [http://en.wikipedia.org/wiki/Cholinesterase, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased acylcholine acylhydrolase activity" EXACT []
synonym: "decreased anticholineesterase activity" EXACT []
synonym: "decreased benzoylcholinesterase activity" EXACT []
synonym: "decreased BtChoEase activity" EXACT []
synonym: "decreased butyrylcholine esterase activity" EXACT []
synonym: "decreased butyrylcholinesterase activity" EXACT []
synonym: "decreased choline esterase activity" EXACT []
synonym: "decreased choline esterase II (unspecific) activity" EXACT []
synonym: "decreased non-specific cholinesterase activity" EXACT []
synonym: "decreased propionylcholinesterase activity" EXACT []
synonym: "decreased pseudocholinesterase activity" EXACT []
is_a: MP:0020029 ! abnormal cholinesterase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020035
name: abnormal coumarin hydroxylase activity
def: "anomaly in the ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+" [GO:0008389, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020036
name: decreased coumarin hydroxylase activity
def: "decreased ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+" [GO:0008389, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020035 ! abnormal coumarin hydroxylase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020037
name: increased coumarin hydroxylase activity
def: "increased ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+" [GO:0008389, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020035 ! abnormal coumarin hydroxylase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020038
name: retina macular degeneration
def: "retrogressive pathological change of the macula lutea" [https://orcid.org/0000-0003-4606-0597]
synonym: "retinal macular degeneration" EXACT []
is_a: MP:0001326 ! retina degeneration

[Term]
id: MP:0020039
name: increased bone ossification
def: "increase  in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0020040
name: decreased bone ossification
def: "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008271 ! abnormal bone ossification

[Term]
id: MP:0020041
name: decreased susceptibility to pulmonary hyaline membrane formation
def: "decreased likelihood of the presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased resistance to pulmonary hyaline membrane formation" EXACT []
synonym: "reduced susceptibility to pulmonary hyaline membrane formation" EXACT []
synonym: "resistant to pulmonary hyaline membrane formation" EXACT []
is_a: MP:0031106 ! abnormal susceptibility to pulmonary hyaline membrane formation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020042
name: abnormal glucose-6-phosphate dehydrogenase activity
def: "anomaly in the ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+" [http://enzyme.expasy.org/EC/1.1.1.49, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020043
name: decreased glucose-6-phosphate dehydrogenase activity
def: "decreased ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+" [http://enzyme.expasy.org/EC/1.1.1.49, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020042 ! abnormal glucose-6-phosphate dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020044
name: increased glucose-6-phosphate dehydrogenase activity
def: "increased ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+" [http://enzyme.expasy.org/EC/1.1.1.49, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020042 ! abnormal glucose-6-phosphate dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020045
name: abnormal tyrosine aminotransferase activity
def: "anomaly in the ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid" [GO:0070547, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal L-tyrosine aminotransferase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020046
name: decreased tyrosine aminotransferase activity
def: "decreased ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid" [GO:0070547, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased L-tyrosine aminotransferase activity" EXACT []
is_a: MP:0020045 ! abnormal tyrosine aminotransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020047
name: increased tyrosine aminotransferase activity
def: "increased ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid" [GO:0070547, https://orcid.org/0000-0001-5208-3432]
synonym: "increased L-tyrosine aminotransferase activity" EXACT []
is_a: MP:0020045 ! abnormal tyrosine aminotransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020048
name: abnormal maltase activity
def: "anomaly in the ability to catalyze the reaction: alpha-maltose + H2O = 2 alpha-D-glucose" [http://biocyc.org/META/NEW-IMAGE?type=NIL&object=RXN-2141, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal maltose alpha-glucosidase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020049
name: decreased maltase activity
def: "decreased ability to catalyze the reaction:alpha-maltose + H2O = 2 alpha-D-glucose" [http://biocyc.org/META/NEW-IMAGE?type=NIL&object=RXN-2141, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased maltose alpha-glucosidase activity" EXACT []
is_a: MP:0020048 ! abnormal maltase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020050
name: increased maltase activity
def: "increased ability to catalyze the reaction:alpha-maltose + H2O = 2 alpha-D-glucose" [http://biocyc.org/META/NEW-IMAGE?type=NIL&object=RXN-2141, https://orcid.org/0000-0001-5208-3432]
synonym: "increased maltose alpha-glucosidase activity" EXACT []
is_a: MP:0020048 ! abnormal maltase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020051
name: abnormal procollagen-proline 4-dioxygenase activity
def: "anomaly in the ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2" [http://enzyme.expasy.org/EC/1.14.11.2, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020052
name: decreased procollagen-proline 4-dioxygenase activity
def: "decreased ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2" [http://enzyme.expasy.org/EC/1.14.11.2, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020051 ! abnormal procollagen-proline 4-dioxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020053
name: increased procollagen-proline 4-dioxygenase activity
def: "increased ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2" [http://enzyme.expasy.org/EC/1.14.11.2, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020051 ! abnormal procollagen-proline 4-dioxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020054
name: abnormal beta-glucuronidase activity
def: "anomaly in the ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020055
name: abnormal spermatazoal beta-glucuronidase activity
def: "anomaly in the ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020054 ! abnormal beta-glucuronidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020056
name: decreased beta-glucuronidase activity
def: "reduced ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020054 ! abnormal beta-glucuronidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020057
name: decreased spermatazoal beta-glucuronidase activity
def: "reduced ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020055 ! abnormal spermatazoal beta-glucuronidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020058
name: increased beta-glucuronidase activity
def: "greater ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020054 ! abnormal beta-glucuronidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020059
name: increased spermatazoal beta-glucuronidase activity
def: "greater ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa" [http://enzyme.expasy.org/EC/3.2.1.31, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020055 ! abnormal spermatazoal beta-glucuronidase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020060
name: abnormal hypoxanthine phosphoribosyltransferase activity
def: "anomaly in the ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate" [http://enzyme.expasy.org/EC/2.4.2.8, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020061
name: decreased hypoxanthine phosphoribosyltransferase activity
def: "decreased ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate" [http://enzyme.expasy.org/EC/2.4.2.8, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020060 ! abnormal hypoxanthine phosphoribosyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020062
name: increased hypoxanthine phosphoribosyltransferase activity
def: "increased ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate" [http://enzyme.expasy.org/EC/2.4.2.8, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020060 ! abnormal hypoxanthine phosphoribosyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020063
name: abnormal thiopurine S-methyltransferase activity
def: "anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether" [http://enzyme.expasy.org/EC/2.1.1.67, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020064
name: decreased thiopurine S-methyltransferase activity
def: "decreased ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether" [http://enzyme.expasy.org/EC/2.1.1.67, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020063 ! abnormal thiopurine S-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020065
name: increased thiopurine S-methyltransferase activity
def: "increased ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether" [http://enzyme.expasy.org/EC/2.1.1.67, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020063 ! abnormal thiopurine S-methyltransferase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020066
name: abnormal neocortex size
def: "deviation from the average range of neocortex size compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0008547 ! abnormal neocortex morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020067
name: increased neocortex size
def: "greater than average size of the neocortex" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020066 ! abnormal neocortex size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020068
name: increased neocortex volume
def: "increase from the average range of neocortex volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020067 ! increased neocortex size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020069
name: decreased neocortex size
def: "size reduction or truncation of the neocortex" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020066 ! abnormal neocortex size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020070
name: decreased neocortex volume
def: "decrease from the average range of neocortex volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020069 ! decreased neocortex size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020071
name: decreased blood catalase activity
def: "reduced ability of the catalase enzyme in the blood to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0011594 ! decreased catalase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020072
name: increased blood catalase activity
def: "increased ability of the catalase enzyme in the blood to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0011593 ! increased catalase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020073
name: abnormal tyrosine 3-monooxygenase activity
def: "anomaly in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal L-tyrosine hydroxylase activity" EXACT []
synonym: "abnormal L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) activity" EXACT []
synonym: "abnormal tyrosine 3-hydroxylase activity" EXACT []
synonym: "abnormal tyrosine hydroxylase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020074
name: abnormal brain tyrosine 3-monooxygenase activity
def: "anomaly in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal brain tyrosine hydroxylase activity" EXACT []
is_a: MP:0020073 ! abnormal tyrosine 3-monooxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020075
name: increased tyrosine 3-monooxygenase activity
def: "greater ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "increased tyrosine hydroxylase activity" EXACT []
is_a: MP:0020073 ! abnormal tyrosine 3-monooxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020076
name: increased brain tyrosine 3-monooxygenase activity
def: "greater ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "increased brain tyrosine hydroxylase activity" EXACT []
is_a: MP:0020074 ! abnormal brain tyrosine 3-monooxygenase activity
is_a: MP:0020075 ! increased tyrosine 3-monooxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020077
name: decreased tyrosine 3-monooxygenase activity
def: "reduction in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased tyrosine hydroxylase activity" EXACT []
is_a: MP:0020073 ! abnormal tyrosine 3-monooxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020078
name: decreased brain tyrosine 3-monooxygenase activity
def: "reduction in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain" [http://en.wikipedia.org/wiki/Tyrosine_hydroxylase, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased brain tyrosine hydroxylase activity" EXACT []
is_a: MP:0020074 ! abnormal brain tyrosine 3-monooxygenase activity
is_a: MP:0020077 ! decreased tyrosine 3-monooxygenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020079
name: increased incidence of epicardial mineralization
def: "increased incidence of mineral deposits in the epicardial tissue" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003057 ! abnormal epicardium morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020080
name: increased bone mineralization
def: "increase in the rate at which minerals are deposited into bone" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002896 ! abnormal bone mineralization

[Term]
id: MP:0020081
name: myocardium degeneration
def: "deterioration or the inflammation of the myocardium often caused by oxygen deprivation. It generally occurs as a result of obstruction of the blood supply and can trigger a heart attack" [http://www.ask.com/question/what-is-myocardial-degeneration, https://orcid.org/0000-0001-5208-3432]
synonym: "degenerative myocardium" EXACT []
synonym: "myocardial degeneration" EXACT []
is_a: MP:0004215 ! abnormal myocardial fiber physiology
is_a: MP:0009416 ! cardiac muscle degeneration
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020082
name: increased hippocampus volume
def: "deviation from the average range of the hippocampus volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0008282 ! enlarged hippocampus
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020083
name: decreased hippocampus volume
def: "decrease from the average range of the hippocampus volume compared to normal" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0008283 ! small hippocampus
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020084
name: short ears
def: "reduced length of the ears" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased outer ear length" EXACT []
is_a: MP:0000018 ! small ears
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020085
name: long ears
def: "increased length of the ears" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased outer ear length" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-23T00:00:00Z

[Term]
id: MP:0020086
name: abnormal susceptibility to non-insulin-dependent diabetes
def: "an anomaly in the likelihood to develop non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001764 ! abnormal homeostasis
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020087
name: increased susceptibility to non-insulin-dependent diabetes
def: "increased likelihood to develop non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020086 ! abnormal susceptibility to non-insulin-dependent diabetes
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020088
name: decreased susceptibility to non-insulin-dependent diabetes
def: "decreased likelihood to develop non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020086 ! abnormal susceptibility to non-insulin-dependent diabetes
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020089
name: increased susceptibility to diet-induced non-insulin dependent diabetes
def: "increased likelihood to develop diet-induced non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020087 ! increased susceptibility to non-insulin-dependent diabetes
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020090
name: decreased susceptibility to diet-induced non-insulin dependent diabetes
def: "decreased likelihood to develop diet-induced non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020088 ! decreased susceptibility to non-insulin-dependent diabetes
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020091
name: abnormal susceptibility to diet-induced non-insulin dependent diabetes
def: "an anomaly in the likelihood to develop diet-induced non-insulin-dependent diabetes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020086 ! abnormal susceptibility to non-insulin-dependent diabetes
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020092
name: abnormal susceptibility to aortic cartilaginous metaplasia
def: "an anomaly in the susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020093
name: decreased susceptibility to aortic cartilaginous metaplasia
def: "decreased susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020092 ! abnormal susceptibility to aortic cartilaginous metaplasia
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020094
name: increased susceptibility to aortic cartilaginous metaplasia
def: "increased susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020092 ! abnormal susceptibility to aortic cartilaginous metaplasia
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020095
name: abnormal mean heart rate adaptation
def: "an anomaly in the mean of the physiological adaptations of the organisms heart rate in response to long term endurance training" [http://en.wikipedia.org/wiki/Endurance_training, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020096
name: high mean heart rate adaptation
def: "higher than normal mean of the physiological adaptations of the organisms heart rate in response to long term endurance training" [http://en.wikipedia.org/wiki/Endurance_training, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020095 ! abnormal mean heart rate adaptation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020097
name: low mean heart rate adaptation
def: "lower than normal mean of the physiological adaptations of the organisms heart rate in response to long term endurance training" [http://en.wikipedia.org/wiki/Endurance_training, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020095 ! abnormal mean heart rate adaptation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020098
name: abnormal susceptibility to diet-induced aortic fatty streak lesions
def: "an anomaly in the susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries" [http://library.med.utah.edu/WebPath/CVHTML/CV114.html, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020099
name: increased susceptibility to diet-induced aortic fatty streak lesions
def: "increased susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries" [http://library.med.utah.edu/WebPath/CVHTML/CV114.html, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased resistance to diet-induced aortic fatty streak lesions" EXACT []
is_a: MP:0020098 ! abnormal susceptibility to diet-induced aortic fatty streak lesions
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020100
name: decreased susceptibility to diet-induced aortic fatty streak lesions
def: "decreased susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries" [http://library.med.utah.edu/WebPath/CVHTML/CV114.html, https://orcid.org/0000-0001-5208-3432]
synonym: "increased resistance to diet-induced aortic fatty streak lesions" EXACT []
is_a: MP:0020098 ! abnormal susceptibility to diet-induced aortic fatty streak lesions
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020101
name: abnormal hepatic glucose production
def: "an anomaly in the production of glucose in the liver" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002078 ! abnormal glucose homeostasis
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020102
name: increased hepatic glucose production
def: "increased production of glucose in the liver" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020101 ! abnormal hepatic glucose production
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020103
name: decreased hepatic glucose production
def: "decreased production of glucose in the liver" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020101 ! abnormal hepatic glucose production
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020104
name: abnormal nitrate level
def: "altered level of nitrate ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020105
name: increased nitrate level
def: "increased level of nitrate ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020104 ! abnormal nitrate level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020106
name: decreased nitrate level
def: "decreased level of nitrate ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020104 ! abnormal nitrate level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020107
name: abnormal nitrite level
def: "altered level of nitrite ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020108
name: increased nitrite level
def: "increased level of nitrite ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020107 ! abnormal nitrite level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020109
name: decreased nitrite level
def: "decreased level of nitrite ion in fluids and tissues" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020107 ! abnormal nitrite level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020110
name: increased thromboxane level
def: "increased concentrations of thromboxane, a lipid that has a role in clot formation (thrombosis)" [http://en.wikipedia.org/wiki/Thromboxane, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0009818 ! abnormal thromboxane level
is_a: MP:0014460 ! increased lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020111
name: decreased thromboxane level
def: "decreased concentrations of thromboxane, a lipid that has a role in clot formation (thrombosis)" [http://en.wikipedia.org/wiki/Thromboxane, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0009818 ! abnormal thromboxane level
is_a: MP:0014461 ! decreased lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020112
name: abnormal carcass lipid
def: "any anomaly in the total lipid content on the carcass of an organism" [https://orcid.org/0000-0001-5208-3432, PMID:3959773]
is_a: MP:0001547 ! abnormal lipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020113
name: high carcass lipid
def: "increased total lipid content on the carcass of an organism" [https://orcid.org/0000-0001-5208-3432, PMID:3959773]
is_a: MP:0014460 ! increased lipid level
is_a: MP:0020112 ! abnormal carcass lipid
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020114
name: low carcass lipid
def: "decreased total lipid content on the carcass of an organism" [https://orcid.org/0000-0001-5208-3432, PMID:3959773]
is_a: MP:0014461 ! decreased lipid level
is_a: MP:0020112 ! abnormal carcass lipid
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020115
name: abnormal sphingosine level
def: "any anomaly in the concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [http://en.wikipedia.org/wiki/Sphingosine, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012230 ! abnormal sphingolipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020116
name: increased sphingosine level
def: "increased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [http://en.wikipedia.org/wiki/Sphingosine, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020115 ! abnormal sphingosine level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020117
name: decreased sphingosine level
def: "decreased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [http://en.wikipedia.org/wiki/Sphingosine, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0014461 ! decreased lipid level
is_a: MP:0020115 ! abnormal sphingosine level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020118
name: abnormal alcohol dehydrogenase activity
def: "anomaly in the ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor" [GO:0018468, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020119
name: decreased alcohol dehydrogenase activity
def: "decreased ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor" [GO:0018468, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020118 ! abnormal alcohol dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020120
name: increased alcohol dehydrogenase activity
def: "increased ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor" [GO:0018468, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020118 ! abnormal alcohol dehydrogenase activity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020121
name: obsolete abnormal tyrosine 3-monooxygenase activity
def: "anomaly in the ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
comment: obsoleted because it is a duplicate term
synonym: "abnormal tyrosine hydroxylase activity" EXACT []
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0020073
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020122
name: obsolete decreased tyrosine 3-monooxygenase activity
def: "decreased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
comment: obsoleted because it is a duplicate term
synonym: "decreased tyrosine hydroxylase activity" EXACT []
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0020077
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020123
name: obsolete increased tyrosine 3-monooxygenase activity
def: "increased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O" [http://enzyme.expasy.org/EC/4.1.1.53, https://orcid.org/0000-0001-5208-3432]
comment: obsoleted because is is a duplicate term
synonym: "increased tyrosine hydroxylase activity" EXACT []
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0020075
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020124
name: abnormal circulating HDL phospholipid level
def: "any anomaly in the amount of the complex of high density lipoprotein and  phospholipid in the blood, serum, or plasma" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0006084 ! abnormal circulating phospholipid level
is_a: MP:0010330 ! abnormal circulating lipoprotein level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020125
name: increased circulating HDL phospholipid level
def: "increase in the concentration in the blood of HDL phospholipid" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003980 ! increased circulating phospholipid level
is_a: MP:0020124 ! abnormal circulating HDL phospholipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020126
name: decreased circulating HDL phospholipid level
def: "decrease in the concentration in the blood of HDL phospholipid" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003981 ! decreased circulating phospholipid level
is_a: MP:0020124 ! abnormal circulating HDL phospholipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020127
name: abnormal circulating non-HDL phospholipid level
def: "any anomaly of the amount of phospholipid not complexed to high density lipropoteins in the blood, serum, or plasma" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0006084 ! abnormal circulating phospholipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020128
name: increased circulating non-HDL phospholipid level
def: "increase in the concentration in the blood of non-HDL phospholipid" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003980 ! increased circulating phospholipid level
is_a: MP:0020127 ! abnormal circulating non-HDL phospholipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020129
name: decreased circulating non-HDL phospholipid level
def: "decrease in the concentration in the blood of non-HDL phospholipid" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003981 ! decreased circulating phospholipid level
is_a: MP:0020127 ! abnormal circulating non-HDL phospholipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020130
name: abnormal total fat pad weight
def: "anomaly in average total weight of the fat pad compared to controls" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005334 ! abnormal fat pad morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020131
name: abnormal gallbladder volume
def: "any anomaly in the amount of space occupied by gallbladder lumen in the body" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020134 ! abnormal gallbladder size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020132
name: increased gallbladder volume
def: "greater than average amount of space occupied by gallbladder in the body" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0009342 ! enlarged gallbladder
is_a: MP:0020131 ! abnormal gallbladder volume
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020133
name: decreased gallbladder volume
def: "less than average amount of space occupied by gallbladder in the body" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005675 ! small gallbladder
is_a: MP:0020131 ! abnormal gallbladder volume
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020134
name: abnormal gallbladder size
def: "an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005084 ! abnormal gallbladder morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020135
name: abnormal heart ventricle wall thickness
def: "anomaly in the depth of the cardiac wall of the heart ventricles" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0031532 ! abnormal heart ventricle wall morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020136
name: abnormal interventricular septum thickness
def: "an anomaly in the thickness of the wall between the two lower chambers of the heart compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000281 ! abnormal interventricular septum morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-28T00:00:00Z

[Term]
id: MP:0020137
name: decreased bone mineralization
def: "decrease in the rate at which minerals are deposited into bone" []
is_a: MP:0002896 ! abnormal bone mineralization

[Term]
id: MP:0020138
name: delayed bone mineralization
def: "late onset of the process by which minerals are deposited into bone" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002896 ! abnormal bone mineralization

[Term]
id: MP:0020139
name: abnormal brain external capsule morphology
def: "any structural anomaly of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum; the white matter of the external capsule contains fibers known as corticocortical association fibers which are responsible for connecting the cerebral cortex to another cortical area; the capsule appears as a thin white sheet of white matter and provides a route for cholinergic fibers from the basal forebrain to the cerebral cortex; it eventually joins the internal capsule around the lentiform nucleus" [FMA:61959, https://en.wikipedia.org/wiki/External_capsule]
synonym: "abnormal external capsule of telencephalon" EXACT [UBERON:0004545]
is_a: MP:0008026 ! abnormal brain white matter morphology
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology

[Term]
id: MP:0020140
name: increased brain external capsule size
def: "larger than the normal physical proportions of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum" [https://orcid.org/0000-0003-4606-0597, PMID:24997765]
is_a: MP:0020139 ! abnormal brain external capsule morphology

[Term]
id: MP:0020141
name: decreased brain external capsule size
def: "smaller than the normal physical proportions of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020139 ! abnormal brain external capsule morphology

[Term]
id: MP:0020142
name: increased anti-sperm antibody level
def: "elevated level of antibodies to sperm antigens, usually due to compromised Sertoli cell barrier (blood-testis barrier) function; ASAs may be found in the circulation, either free or as immune complexes, in seminal fluid and/or attached to various antigenic sites on the sperm surface (head, midpiece or tail)" [PMID:24803656]
synonym: "increased anti sperm antibody level" EXACT []
synonym: "increased ASA level" EXACT []
is_a: MP:0003725 ! increased autoantibody level

[Term]
id: MP:0020143
name: abnormal adrenal gland x-zone size
def: "an anomaly in the size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal adrenal gland x zone size" EXACT []
is_a: MP:0008296 ! abnormal adrenal gland x-zone morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020144
name: small adrenal gland x-zone
def: "reduced size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased adrenal gland x-zone size" EXACT []
synonym: "small adrenal gland x zone" EXACT []
is_a: MP:0020143 ! abnormal adrenal gland x-zone size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020145
name: enlarged adrenal gland x-zone
def: "increased size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [https://orcid.org/0000-0001-5208-3432]
synonym: "enlarged adrenal gland x zone" EXACT []
synonym: "increased adrenal gland x-zone size" EXACT []
is_a: MP:0020143 ! abnormal adrenal gland x-zone size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020146
name: abnormal vascular endothelial cell proliferation
def: "anomaly in the ability of the cells that line the vasculature to undergo expansion by cell division" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0004003 ! abnormal vascular endothelial cell physiology

[Term]
id: MP:0020147
name: abnormal defecation amount
def: "anomaly in the amount of discharge of feces from the body compared to the control" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal defaecation amount" EXACT []
is_a: MP:0003866 ! abnormal defecation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020148
name: abnormal susceptibility to induced morbidity/mortality
def: "anomaly in the amount of an external agent required to cause death or diseased state" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal resistance to induced morbidity/mortality" EXACT []
synonym: "abnormal sensitivity to induced morbidity/mortality" EXACT []
synonym: "abnormal survival following induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020149
name: abnormal mortality induced by ionizing radiation
def: "anomaly in the sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays, resulting in death" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012734 ! abnormal response to radiation
is_a: MP:0020148 ! abnormal susceptibility to induced morbidity/mortality
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020150
name: abnormal timing of vaginal opening
def: "anomaly in the age of the opening of the genital canal in a female compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001937 ! abnormal sexual maturation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020151
name: abnormal circulating non-HDL cholesterol level
def: "any anomaly in the amount in the blood of non-HDL cholesterol" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000180 ! abnormal circulating cholesterol level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020152
name: abnormal oocyte number
def: "anomaly in the number of germ cells in the female compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001125 ! abnormal oocyte morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-29T00:00:00Z

[Term]
id: MP:0020153
name: abnormal urine albumin level
def: "anomaly in the amount of albumin in the urine" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0006315 ! abnormal urine protein level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020154
name: impaired humoral immune response
def: "impaired response of the immune system that mediates secreted antibodies produced in B cells" [https://orcid.org/0000-0001-5208-3432]
synonym: "impaired humoural immune response" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "low humoral immune response" EXACT []
synonym: "low humoural immune response" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001800 ! abnormal humoral immune response
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020155
name: enhanced humoral immune response
def: "enhanced response of the immune system that mediates secreted antibodies produced in B cells" [https://orcid.org/0000-0001-5208-3432]
synonym: "enhanced humoural immune response" EXACT [https://orcid.org/0000-0002-6490-7723]
synonym: "high humoral immune response" EXACT []
synonym: "high humoural immune response" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001800 ! abnormal humoral immune response
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020156
name: multinucleated pancreatic acinar cells
def: "pancreatic acinar cells contain multiple nuclei" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0009146 ! abnormal pancreatic acinar cell morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020157
name: abnormal behavioral response to alcohol
def: "any anomaly in the behavioral response induced by alcohol, such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal behavioural response to alcohol" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020158
name: abnormal behavioral response to cocaine
def: "any anomaly in the behavioral response induced by cocaine, such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal behavioural response to cocaine" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020159
name: abnormal behavioral response to morphine
def: "any anomaly in the behavioral response induced by morphine, such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal behavioural response to morphine" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020160
name: abnormal behavioral response to nicotine
def: "any anomaly in the behavioral response induced by nicotine, such as induced hyperactivity or stereotypic behavior" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal behavioural response to nicotine" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020161
name: increased vascular endothelial cell proliferation
def: "increase in the expansion rate of any vascular endothelial cell population by cell division" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0020146 ! abnormal vascular endothelial cell proliferation

[Term]
id: MP:0020162
name: decreased susceptibility to virus induced diabetes
def: "reduced likelihood that an organism will develop diabetes from a viral infection or from components of or toxins produced by a virus" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased resistance to virus induced diabetes" EXACT []
synonym: "reduced susceptibility to virus induced diabetes" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020163
name: increased susceptibility to virus induced diabetes
def: "increased likelihood that an organism will develop diabetes from a viral infection or from components of or toxins produced by a virus" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased resistance to virus induced diabetes" EXACT []
is_a: MP:0002418 ! increased susceptibility to viral infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020164
name: abnormal quadriceps weight
def: "anomaly in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010225 ! abnormal quadriceps morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020165
name: abnormal soleus weight
def: "anomaly in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003081 ! abnormal soleus morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020166
name: abnormal tibialis anterior weight
def: "anomaly in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003083 ! abnormal tibialis anterior morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020167
name: abnormal vertical activity
def: "altered ability or desire to jump or rear" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001392 ! abnormal locomotor behavior
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020168
name: decreased thyroid gland weight
def: "lower than average weight of the thyroid gland" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002951 ! small thyroid gland
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020169
name: increased thyroid gland weight
def: "higher than average weight of the thyroid gland" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005355 ! enlarged thyroid gland
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020170
name: vacuolated thymus epithelium
def: "the presence of clear, sharply defined vacuoles in the thymus epithelium" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0009544 ! abnormal thymus epithelium morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020171
name: abnormal IgA level
def: "deviation from the normal levels of immunoglobulin class A level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002490 ! abnormal immunoglobulin level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020172
name: abnormal IgD level
def: "deviation from the normal levels of immunoglobulin class D level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002490 ! abnormal immunoglobulin level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020173
name: abnormal IgE level
def: "deviation from the normal levels of immunoglobulin class E level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002490 ! abnormal immunoglobulin level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020174
name: abnormal IgG level
def: "deviation from the normal levels of immunoglobulin class G level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002490 ! abnormal immunoglobulin level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020175
name: abnormal IgG1 level
def: "deviation from the normal levels of immunoglobulin class G1 level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020174 ! abnormal IgG level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020176
name: abnormal IgG2a level
def: "deviation from the normal levels of immunoglobulin class G2a level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0013802 ! abnormal IgG2 level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020177
name: abnormal IgG2b level
def: "deviation from the normal levels of immunoglobulin class G2b level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0013802 ! abnormal IgG2 level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020178
name: abnormal IgG2c level
def: "deviation from the normal levels of immunoglobulin class G2c level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0013802 ! abnormal IgG2 level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020179
name: abnormal IgG3 level
def: "deviation from the normal levels of immunoglobulin class G3 level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020174 ! abnormal IgG level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020180
name: abnormal IgM level
def: "deviation from the normal levels of immunoglobulin class M level" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002490 ! abnormal immunoglobulin level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020181
name: obsolete abnormal body weight
def: "anomaly in the average weight compared to the control" [https://orcid.org/0000-0001-5208-3432]
comment: Obsoleting because it is a duplicate
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0001259
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020182
name: abnormal body mass index
def: "anomaloy in the average of a measure of weight for height compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0005451 ! abnormal body composition
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020183
name: abnormal susceptibility to fungal infection
def: "a change in the likelihood that an organism will develop ill effects from a fungal infection or from components of or toxins produced by a fungi" [https://orcid.org/0000-0001-5208-3432]
synonym: "altered susceptibility to fungal infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020184
name: abnormal susceptibility to parasitic infection
def: "a change in the likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by a parasite" [https://orcid.org/0000-0001-5208-3432]
synonym: "altered susceptibility to parasitic infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020185
name: abnormal susceptibility to viral infection
def: "a change in the likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [https://orcid.org/0000-0001-5208-3432]
synonym: "altered susceptibility to viral infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020186
name: abnormal susceptibility to bacterial infection
def: "a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [https://orcid.org/0000-0001-5208-3432]
synonym: "altered susceptibility to bacterial infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020187
name: abnormal susceptibility to prion infection
def: "altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [https://orcid.org/0000-0001-5208-3432]
synonym: "altered susceptibility to prion infection" EXACT []
is_a: MP:0001793 ! abnormal susceptibility to infection
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-04-30T00:00:00Z

[Term]
id: MP:0020188
name: abnormal classified tumor incidence
def: "an anomaly in the expected number of tumors with a specific classification type in a given population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal classified tumour incidence" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002019 ! abnormal tumor incidence
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020189
name: abnormal adenoma incidence
def: "an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020188 ! abnormal classified tumor incidence
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020190
name: abnormal lung adenoma incidence
def: "an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0020189 ! abnormal adenoma incidence
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020191
name: abnormal lymphocyte activation involved in immune response
def: "an anomaly in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002285, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003945 ! abnormal lymphocyte physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020192
name: decreased lymphocyte activation involved in immune response
def: "decreased change in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002285, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020191 ! abnormal lymphocyte activation involved in immune response
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020193
name: increased lymphocyte activation involved in immune response
def: "Increased change in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002285, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020191 ! abnormal lymphocyte activation involved in immune response
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020194
name: abnormal glycosphingolipid level
def: "any anomaly in the concentrations of glycosphingolipids, a subtype of glycolipids containing the amino alcohol sphingosine, in the body" [http://en.wikipedia.org/wiki/Glycosphingolipid, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0012230 ! abnormal sphingolipid level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020195
name: obsolete increased sulphatide level
def: "increased concentrations of sulfatides, a class of sulfated galactosylceramides, in the body" [http://en.wikipedia.org/wiki/Sulfatide, https://orcid.org/0000-0001-5208-3432]
comment: obsoleted term because it was a duplicate
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0020006
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020196
name: obsolete decreased sulphatide level
def: "decreased concentrations of sulfatides, a class of sulfated galactosylceramides, in the body" [http://en.wikipedia.org/wiki/Sulfatide, https://orcid.org/0000-0001-5208-3432]
comment: obsoleted term because it was a duplicate
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
replaced_by: MP:0020005
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020197
name: obsolete decreased reticular tumor incidence
def: "OBSOLETE less than the expected number of neoplams in the reticulum, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased reticular tumour incidence" EXACT [https://orcid.org/0000-0002-6490-7723]
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020198
name: decreased mononuclear phagocyte tumor incidence
def: "less than the expected number of neoplams in mononuclear phagocyte cells, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased mononuclear phagocyte tumour incidence" EXACT []
synonym: "decreased reticuloendothelial tumour incidence" EXACT []
is_a: MP:0012420 ! decreased hemolymphoid system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020199
name: obsolete increased reticular tumor incidence
def: "OBSOLETE greater than the expected number of neoplams in the reticulum, usually in the form of a distinct mass, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased reticular tumour incidence" EXACT []
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020200
name: increased mononuclear phagocyte tumor incidence
def: "more than the expected number of neoplams in mononuclear phagocyte cells, in a specific population in a given time period" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased mononuclear phagocyte tumour incidence" EXACT []
synonym: "increased reticuloendothelial tumour incidence" EXACT []
is_a: MP:0010296 ! increased hemolymphoid system tumor incidence
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-01T00:00:00Z

[Term]
id: MP:0020201
name: abnormal granulocyte number
def: "an anomaly in the number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0002441 ! abnormal granulocyte morphology

[Term]
id: MP:0020202
name: abnormal macrophage cell number
def: "an anomaly in the number of macrophages" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000217 ! abnormal leukocyte cell number
is_a: MP:0002446 ! abnormal macrophage morphology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-15T00:00:00Z

[Term]
id: MP:0020203
name: abnormal mast cell number
def: "an anomaly in the number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000359 ! abnormal mast cell morphology
is_a: MP:0020201 ! abnormal granulocyte number
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-15T00:00:00Z

[Term]
id: MP:0020204
name: abnormal heart left ventricle weight
def: "anomaly in the average weight of the left ventricle compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010578 ! abnormal heart left ventricle size

[Term]
id: MP:0020205
name: abnormal heart right ventricle weight
def: "anomaly in the average weight of the right ventricle compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010577 ! abnormal heart right ventricle size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-15T00:00:00Z

[Term]
id: MP:0020206
name: abnormal heart left atrium weight
def: "anomaly in the average weight of the heart left atrium compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003923 ! abnormal heart left atrium morphology
is_a: MP:0031576 ! abnormal heart atrium size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-15T00:00:00Z

[Term]
id: MP:0020207
name: abnormal heart right atrium weight
def: "anomaly in the average weight of the heart right atrium compared to the control" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0031576 ! abnormal heart atrium size
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky
creation_date: 2014-05-15T00:00:00Z

[Term]
id: MP:0020208
name: abnormal withers
def: "abnormal height of the ridge between the shoulder blades of a four-legged mammal" [http://en.wikipedia.org/wiki/Withers, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001253 ! abnormal body height
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020209
name: low withers
def: "low height of the ridge between the shoulder blades of a four-legged mammal" [http://en.wikipedia.org/wiki/Withers, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020208 ! abnormal withers
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020210
name: high withers
def: "high height of the ridge between the shoulder blades of a four-legged mammal" [http://en.wikipedia.org/wiki/Withers, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020208 ! abnormal withers
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020211
name: slow movement
def: "decreased rate or speed of the coordinated movements executed with a purpose" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0031392 ! hypoactivity
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020212
name: impaired leukocyte migration
def: "impaired ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV" [https://orcid.org/0000-0001-5208-3432]
synonym: "impaired leucocyte migration" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003156 ! abnormal leukocyte migration
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020213
name: enhanced leukocyte migration
def: "enhanced ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV" [https://orcid.org/0000-0001-5208-3432]
synonym: "enhanced leucocyte migration" EXACT [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003156 ! abnormal leukocyte migration
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020214
name: increased susceptibility to malignant hyperthermia
def: "increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine" [http://en.wikipedia.org/wiki/Malignant_hyperthermia, https://orcid.org/0000-0001-5208-3432]
synonym: "susceptible to malignant hyperpyrexia" EXACT []
synonym: "susceptible to malignant hyperthermia susceptibility" EXACT []
synonym: "susceptible to malignant hyperthermia syndrome" EXACT []
is_a: MP:0008873 ! increased physiological sensitivity to xenobiotic
is_a: MP:0011019 ! abnormal adaptive thermogenesis
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020215
name: impaired blood coagulation
def: "impaired ability of the blood to clot" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002551 ! abnormal blood coagulation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020216
name: decreased circulating complement protein level
def: "less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010215 ! abnormal circulating complement protein level
is_a: MP:0014502 ! decreased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020217
name: increased circulating complement protein level
def: "more than the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0010215 ! abnormal circulating complement protein level
is_a: MP:0014501 ! increased circulating protein level
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020218
name: abnormal tear production
def: "an anomaly in the amount of fluid produced in the eye" [https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal lachrymation" EXACT []
synonym: "abnormal lacrimation" EXACT []
synonym: "abnormal tear secretion" EXACT []
synonym: "lachrymation abnormality" EXACT []
synonym: "lacrimation abnormality" EXACT []
is_a: MP:0005253 ! abnormal eye physiology
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020219
name: increased tear production
def: "increased production of the amount of fluid produced in the eye" [https://orcid.org/0000-0001-5208-3432]
synonym: "hyperlachrymation" EXACT []
synonym: "hyperlacrimation" EXACT []
synonym: "increased lachrymation" EXACT []
synonym: "increased lacrimation" EXACT []
synonym: "increased tear secretion" EXACT []
is_a: MP:0020218 ! abnormal tear production
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: MP:0020220
name: decreased tear production
def: "decreased production of the amount of fluid produced in the eye" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased lachrymation" EXACT []
synonym: "decreased lacrimation" EXACT []
synonym: "decreased tear secretion" EXACT []
synonym: "hypolachrymation" EXACT []
synonym: "hypolacrimation" EXACT []
synonym: "reduced lachrymation" EXACT []
synonym: "reduced lacrimation" EXACT []
synonym: "reduced tear production" EXACT []
synonym: "reduced tear secretion" EXACT []
is_a: MP:0020218 ! abnormal tear production
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020221
name: reduced foot pad pigmentation
def: "lack of color in the body of fat on the foot" [https://orcid.org/0000-0001-5208-3432]
synonym: "blanched foot pads" EXACT []
synonym: "blanched pads" EXACT []
synonym: "decreased pigmentation in foot pads" EXACT []
is_a: MP:0000574 ! abnormal foot pad morphology
is_a: MP:0011568 ! decreased foot pigmentation
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020222
name: abnormal alertness
def: "anomaly in the level of awareness or attentiveness" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0004924 ! abnormal behavior
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020223
name: increased alertness
def: "increased or heightened awareness or attentiveness" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020222 ! abnormal alertness
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020224
name: decreased alertness
def: "decreased level of awareness or attentiveness" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020222 ! abnormal alertness
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
created_by: nvasilevsky

[Term]
id: MP:0020225
name: bone necrosis
def: "morphological changes resulting from pathological death of some or all bone tissue; usually due to irreversible damage" [https://orcid.org/0000-0001-5208-3432]
synonym: "necrotic bone" EXACT []
synonym: "necrotic bones" EXACT []
is_a: MP:0005508 ! abnormal skeleton morphology

[Term]
id: MP:0020226
name: decreased hemangioma incidence
def: "fewer than the expected number of benign tumors characterized by blood-filled spaces lined by benign endothelial cells, occurring in a specific population in a given time period; a cavernous hemangioma is characterized by large endothelial spaces (caverns), and a capillary hemangioma is characterized by small endothelial spaces" [HP:0001028] {created_by="https://orcid.org/0000-0001-5208-3432"}
synonym: "decreased haemangioma incidence" EXACT []
is_a: MP:0010283 ! decreased classified tumor incidence

[Term]
id: MP:0020227
name: abnormal proline oxidase activity
def: "altered ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2" [http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5625] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0020228
name: decreased proline oxidase activity
def: "decreased ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2" [http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5625, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020227 ! abnormal proline oxidase activity

[Term]
id: MP:0020229
name: increased proline oxidase activity
def: "increased ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2" [http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5625] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0020227 ! abnormal proline oxidase activity

[Term]
id: MP:0020230
name: subcutaneous adipose tissue degeneration
def: "a retrogressive impairment of function or destruction of the adipose tissue layer beneath the skin" [https://orcid.org/0000-0001-5208-3432]
synonym: "hypodermal fat layer degeneration" EXACT []
synonym: "panniculus adiposus degeneration" EXACT []
synonym: "subcutaneous fat layer degeneration" EXACT []
is_a: MP:0011156 ! abnormal hypodermis fat layer morphology

[Term]
id: MP:0020231
name: abnormal tyrosine aminotransferase level
def: "anomaly in the level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate" [PMID:1349265] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020232
name: increased tyrosine aminotransferase level
def: "increased level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate" [PMID:1349265] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020231 ! abnormal tyrosine aminotransferase level

[Term]
id: MP:0020233
name: decreased tyrosine aminotransferase level
def: "decreased level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate" [PMID:1349265] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020231 ! abnormal tyrosine aminotransferase level

[Term]
id: MP:0020234
name: decreased basal metabolism
def: "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0008961 ! abnormal basal metabolism

[Term]
id: MP:0020235
name: black belted
def: "the appearance of a stripe of black fur around the circumference of the abdomen" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002075 ! abnormal coat/hair pigmentation

[Term]
id: MP:0020236
name: abnormal proline level
def: "abnormal concentration of proline and/or its metabolic derivatives, derived from the amino acid L-glutamate" [ISBN10:1572591536] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0005332 ! abnormal amino acid level

[Term]
id: MP:0020237
name: increased proline level
def: "higher than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate" [ISBN10:1572591536] {created_by="https://orcid.org/0000-0001-5208-3432"}
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0020236 ! abnormal proline level

[Term]
id: MP:0020238
name: decreased proline level
def: "lower than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate" [ISBN10:1572591536] {created_by="https://orcid.org/0000-0001-5208-3432"}
synonym: "reduced proline level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0020236 ! abnormal proline level

[Term]
id: MP:0020239
name: abnormal skeletal muscle cell apoptosis
def: "change in the timing or the number of skeletal muscle cells undergoing programmed cell death" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0002106 ! abnormal muscle physiology

[Term]
id: MP:0020240
name: increased skeletal muscle cell apoptosis
def: "increase in the number of skeletal muscle cells undergoing programmed cell death" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0020239 ! abnormal skeletal muscle cell apoptosis

[Term]
id: MP:0020241
name: decreased skeletal muscle cell apoptosis
def: "decrease in the number of skeletal muscle cells undergoing programmed cell death" [https://orcid.org/0000-0001-5208-3432]
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0020239 ! abnormal skeletal muscle cell apoptosis

[Term]
id: MP:0020242
name: increased autopod size
def: "larger than average size of the autopod" [https://orcid.org/0000-0001-5208-3432]
synonym: "enlarged paws" EXACT []
synonym: "increased paw size" EXACT []
is_a: MP:0014290 ! abnormal autopod size

[Term]
id: MP:0020243
name: abnormal pyruvate kinase activity
def: "anomaly in the ability to transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP" [https://orcid.org/0000-0001-5208-3432, PMID:22182754]
synonym: "abnormal ATP:pyruvate 2-O-phosphotransferase activity" EXACT []
synonym: "abnormal phosphoenol transphosphorylase activity" EXACT []
synonym: "abnormal phosphoenolpyruvate kinase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0020244
name: increased pyruvate kinase activity
def: "increased ability to transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP" [https://orcid.org/0000-0001-5208-3432, PMID:22182754]
synonym: "increased ATP:pyruvate 2-O-phosphotransferase activity" EXACT []
synonym: "increased phosphoenol transphosphorylase activity" EXACT []
synonym: "increased phosphoenolpyruvate kinase activity" EXACT []
is_a: MP:0020243 ! abnormal pyruvate kinase activity

[Term]
id: MP:0020245
name: decreased pyruvate kinase activity
def: "reduced ability to the transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP" [https://orcid.org/0000-0001-5208-3432, PMID:22182754]
synonym: "decreased ATP:pyruvate 2-O-phosphotransferase activity" EXACT []
synonym: "decreased phosphoenol transphosphorylase activity" EXACT []
synonym: "decreased phosphoenolpyruvate kinase activity" EXACT []
is_a: MP:0020243 ! abnormal pyruvate kinase activity

[Term]
id: MP:0020246
name: abnormal circulating arginase level
def: "aberrant concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea" [https://orcid.org/0000-0001-5208-3432, PMID:9806879]
synonym: "abnormal arginine amidinase activity" EXACT []
synonym: "abnormal arginine transamidinase activity" EXACT []
synonym: "abnormal canavanase activity" EXACT []
synonym: "abnormal L-arginase activity" EXACT []
synonym: "abnormal L-arginine amidinohydrolase activity" EXACT []
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0020247
name: increased circulating arginase level
def: "increased concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea" [https://orcid.org/0000-0001-5208-3432, PMID:9806879]
synonym: "increased arginine amidinase activity" EXACT []
synonym: "increased arginine transamidinase activity" EXACT []
synonym: "increased canavanase activity" EXACT []
synonym: "increased L-arginase activity" EXACT []
synonym: "increased L-arginine amidinohydrolase activity" EXACT []
is_a: MP:0014450 ! increased circulating enzyme level
is_a: MP:0020246 ! abnormal circulating arginase level

[Term]
id: MP:0020248
name: decreased circulating arginase level
def: "decreased concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea" [https://orcid.org/0000-0001-5208-3432, PMID:9806879]
synonym: "decreased arginine amidinase activity" EXACT []
synonym: "decreased arginine transamidinase activity" EXACT []
synonym: "decreased canavanase activity" EXACT []
synonym: "decreased L-arginase activity" EXACT []
synonym: "decreased L-arginine amidinohydrolase activity" EXACT []
is_a: MP:0014451 ! decreased circulating enzyme level
is_a: MP:0020246 ! abnormal circulating arginase level

[Term]
id: MP:0020249
name: abnormal argininosuccinate synthetase level
def: "aberrant concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate." [https://orcid.org/0000-0001-5208-3432, PMID:18323623]
synonym: "abnormal arginine succinate synthetase activity" EXACT []
synonym: "abnormal argininosuccinate synthetase activity" EXACT []
synonym: "abnormal argininosuccinic acid synthetase activity" EXACT []
synonym: "abnormal arginosuccinate synthetase activity" EXACT []
synonym: "abnormal citrulline--aspartate ligase activity" EXACT []
synonym: "abnormal L-citrulline:L-aspartate ligase (AMP-forming)" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020250
name: increased argininosuccinate synthetase level
def: "increased concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate." [https://orcid.org/0000-0001-5208-3432, PMID:18323623]
synonym: "increased arginine succinate synthetase activity" EXACT []
synonym: "increased argininosuccinate synthetase activity" EXACT []
synonym: "increased argininosuccinic acid synthetase activity" EXACT []
synonym: "increased arginosuccinate synthetase activity" EXACT []
synonym: "increased citrulline--aspartate ligase activity" EXACT []
synonym: "increased L-citrulline:L-aspartate ligase (AMP-forming)" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020249 ! abnormal argininosuccinate synthetase level

[Term]
id: MP:0020251
name: decreased argininosuccinate synthetase level
def: "decreased concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate." [https://orcid.org/0000-0001-5208-3432, PMID:18323623]
synonym: "decreased arginine succinate synthetase activity" EXACT []
synonym: "decreased argininosuccinate synthetase activity" EXACT []
synonym: "decreased argininosuccinic acid synthetase activity" EXACT []
synonym: "decreased arginosuccinate synthetase activity" EXACT []
synonym: "decreased citrulline--aspartate ligase activity" EXACT []
synonym: "decreased L-citrulline:L-aspartate ligase (AMP-forming)" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020249 ! abnormal argininosuccinate synthetase level

[Term]
id: MP:0020252
name: abnormal collagen level
def: "abnormal level of the main structural protein of the various connective tissues in animals" [https://orcid.org/0000-0001-5208-3432, PMID:11704682]
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0020253
name: increased collagen level
def: "increased level of the main structural protein of the various connective tissues in animals" [https://orcid.org/0000-0001-5208-3432, PMID:11704682]
is_a: MP:0020252 ! abnormal collagen level

[Term]
id: MP:0020254
name: decreased collagen level
def: "decreased level of the main structural protein of the various connective tissues in animals" [https://orcid.org/0000-0001-5208-3432, PMID:11704682]
is_a: MP:0020252 ! abnormal collagen level

[Term]
id: MP:0020255
name: absent circulating factor XII protein
def: "undetectable levels in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro" [https://orcid.org/0000-0001-5208-3432, PMID:22993391]
is_a: MP:0020256 ! abnormal circulating factor XII level

[Term]
id: MP:0020256
name: abnormal circulating factor XII level
def: "aberrant concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro" [https://orcid.org/0000-0001-5208-3432, PMID:22993391]
is_a: MP:0001570 ! abnormal circulating enzyme level

[Term]
id: MP:0020257
name: increased circulating factor XII level
def: "increased concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro" [https://orcid.org/0000-0001-5208-3432, PMID:22993391]
synonym: "elevated circulating factor XII level" EXACT []
is_a: MP:0014450 ! increased circulating enzyme level
is_a: MP:0020256 ! abnormal circulating factor XII level

[Term]
id: MP:0020258
name: decreased circulating factor XII level
def: "decreased concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro" [https://orcid.org/0000-0001-5208-3432, PMID:22993391]
synonym: "reduced circulating factor XII level" EXACT []
is_a: MP:0014451 ! decreased circulating enzyme level
is_a: MP:0020256 ! abnormal circulating factor XII level

[Term]
id: MP:0020259
name: abnormal beta-galactosidase level
def: "abnormal level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides" [https://orcid.org/0000-0001-5208-3432, PMID:7568133]
synonym: "abnormal beta-D-galactanase level" EXACT []
synonym: "abnormal beta-D-galactoside galactohydrolase level" EXACT []
synonym: "abnormal beta-D-lactosidase level" EXACT []
synonym: "abnormal beta-gal level" EXACT []
synonym: "abnormal beta-lactosidase level" EXACT []
synonym: "abnormal exo-(1->4)-beta-D-galactanase level" EXACT []
synonym: "abnormal hydrolact level" EXACT []
synonym: "abnormal lactose hydrolysis level" EXACT []
synonym: "abnormal lactozym level" EXACT []
synonym: "abnormal maxilact level" EXACT []
synonym: "abnormal oryzatym level" EXACT []
synonym: "abnormal S 2107" EXACT []
synonym: "abnormal sumiklat level" EXACT []
synonym: "abnormal trilactase activity" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020260
name: absent beta-galactosidase protein
def: "undetectable levels of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides" [https://orcid.org/0000-0001-5208-3432, PMID:7568133]
synonym: "absent beta-D-galactanase protein" EXACT []
synonym: "absent beta-D-galactoside galactohydrolase protein" EXACT []
synonym: "absent beta-D-lactosidase protein" EXACT []
synonym: "absent beta-gal protein" EXACT []
synonym: "absent beta-lactosidase protein" EXACT []
synonym: "absent exo-(1->4)-beta-D-galactanase protein" EXACT []
synonym: "absent hydrolact protein" EXACT []
synonym: "absent lactose hydrolysis protein" EXACT []
synonym: "absent lactozym protein" EXACT []
synonym: "absent maxilact protein" EXACT []
synonym: "absent oryzatym protein" EXACT []
synonym: "absent S 2107 protein" EXACT []
synonym: "absent sumiklat protein" EXACT []
synonym: "absent trilactase protein" EXACT []
is_a: MP:0020259 ! abnormal beta-galactosidase level

[Term]
id: MP:0020261
name: increased beta-galactosidase level
def: "increased level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides" [https://orcid.org/0000-0001-5208-3432, PMID:7568133]
synonym: "increased beta-D-galactanase level" EXACT []
synonym: "increased beta-D-galactoside galactohydrolase level" EXACT []
synonym: "increased beta-D-lactosidase level" EXACT []
synonym: "increased beta-gal level" EXACT []
synonym: "increased beta-lactosidase level" EXACT []
synonym: "increased exo-(1->4)-beta-D-galactanase level" EXACT []
synonym: "increased hydrolact level" EXACT []
synonym: "increased lactose hydrolysis level" EXACT []
synonym: "increased lactozym level" EXACT []
synonym: "increased maxilact level" EXACT []
synonym: "increased oryzatym level" EXACT []
synonym: "increased S 2107 level" EXACT []
synonym: "increased sumiklat level" EXACT []
synonym: "increased trilactase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020259 ! abnormal beta-galactosidase level

[Term]
id: MP:0020262
name: decreased beta-galactosidase level
def: "decreased level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides" [https://orcid.org/0000-0001-5208-3432, PMID:7568133]
synonym: "decreased beta-D-galactanase level" EXACT []
synonym: "decreased beta-D-galactoside galactohydrolase level" EXACT []
synonym: "decreased beta-D-lactosidase level" EXACT []
synonym: "decreased beta-gal level" EXACT []
synonym: "decreased beta-lactosidase level" EXACT []
synonym: "decreased exo-(1->4)-beta-D-galactanase level" EXACT []
synonym: "decreased hydrolact level" EXACT []
synonym: "decreased lactose hydrolysis level" EXACT []
synonym: "decreased lactozym level" EXACT []
synonym: "decreased maxilact level" EXACT []
synonym: "decreased oryzatym level" EXACT []
synonym: "decreased S 2107 level" EXACT []
synonym: "decreased sumiklat level" EXACT []
synonym: "decreased trilactase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020259 ! abnormal beta-galactosidase level

[Term]
id: MP:0020263
name: abnormal galactosylceramidase level
def: "abnormal level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides)" [https://orcid.org/0000-0001-5208-3432, PMID:20410102]
synonym: "abnormal beta-galactocerebrosidase level" EXACT []
synonym: "abnormal beta-galactosylceramidase level" EXACT []
synonym: "abnormal ceramide galactosidase level" EXACT []
synonym: "abnormal cerebroside beta-galactosidase level" EXACT []
synonym: "abnormal cerebroside galactosidase level" EXACT []
synonym: "abnormal D-galactosyl-N-acylsphingosine galactohydrolase level" EXACT []
synonym: "abnormal galactocerebrosidase level" EXACT []
synonym: "abnormal galactocerebroside beta-galactosidase level" EXACT []
synonym: "abnormal galactocerebroside galactosidase level" EXACT []
synonym: "abnormal galactocerebroside-beta-D-galactosidase level" EXACT []
synonym: "abnormal galactosylceramidase I level" EXACT []
synonym: "abnormal galactosylceramide beta-galactosidase level" EXACT []
synonym: "abnormal galactosylcerebrosidase level" EXACT []
synonym: "abnormal galcerase level" EXACT []
synonym: "abnormal lactosylceramidase I level" EXACT []
synonym: "abnormal lactosylceramidase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020264
name: increased galactosylceramidase level
def: "increased level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides)." [https://orcid.org/0000-0001-5208-3432, PMID:20410102]
synonym: "increased beta-galactocerebrosidase level" EXACT []
synonym: "increased beta-galactosylceramidase level" EXACT []
synonym: "increased ceramide galactosidase level" EXACT []
synonym: "increased cerebroside beta-galactosidase level" EXACT []
synonym: "increased cerebroside galactosidase level" EXACT []
synonym: "increased D-galactosyl-N-acylsphingosine galactohydrolase level" EXACT []
synonym: "increased galactocerebrosidase level" EXACT []
synonym: "increased galactocerebroside beta-galactosidase level" EXACT []
synonym: "increased galactocerebroside galactosidase level" EXACT []
synonym: "increased galactocerebroside-beta-D-galactosidase level" EXACT []
synonym: "increased galactosylceramidase I level" EXACT []
synonym: "increased galactosylceramide beta-galactosidase level" EXACT []
synonym: "increased galactosylcerebrosidase level" EXACT []
synonym: "increased galcerase level" EXACT []
synonym: "increased lactosylceramidase I level" EXACT []
synonym: "increased lactosylceramidase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020263 ! abnormal galactosylceramidase level

[Term]
id: MP:0020265
name: decreased galactosylceramidase level
def: "decreased level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides)." [https://orcid.org/0000-0001-5208-3432, PMID:20410102]
synonym: "decreased beta-galactocerebrosidase level" EXACT []
synonym: "decreased beta-galactosylceramidase level" EXACT []
synonym: "decreased ceramide galactosidase level" EXACT []
synonym: "decreased cerebroside beta-galactosidase level" EXACT []
synonym: "decreased cerebroside galactosidase level" EXACT []
synonym: "decreased D-galactosyl-N-acylsphingosine galactohydrolase level" EXACT []
synonym: "decreased galactocerebrosidase level" EXACT []
synonym: "decreased galactocerebroside beta-galactosidase level" EXACT []
synonym: "decreased galactocerebroside galactosidase level" EXACT []
synonym: "decreased galactocerebroside-beta-D-galactosidase level" EXACT []
synonym: "decreased galactosylceramidase I level" EXACT []
synonym: "decreased galactosylceramide beta-galactosidase level" EXACT []
synonym: "decreased galactosylcerebrosidase level" EXACT []
synonym: "decreased galcerase level" EXACT []
synonym: "decreased lactosylceramidase I level" EXACT []
synonym: "decreased lactosylceramidase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020263 ! abnormal galactosylceramidase level

[Term]
id: MP:0020266
name: absent galactosylceramidase
def: "undetectable level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides)." [https://orcid.org/0000-0001-5208-3432, PMID:20410102]
synonym: "absent beta-galactocerebrosidase protein" EXACT []
synonym: "absent beta-galactosylceramidase protein" EXACT []
synonym: "absent ceramide galactosidase protein" EXACT []
synonym: "absent cerebroside beta-galactosidase protein" EXACT []
synonym: "absent cerebroside galactosidase protein" EXACT []
synonym: "absent D-galactosyl-N-acylsphingosine galactohydrolase protein" EXACT []
synonym: "absent galactocerebrosidase protein" EXACT []
synonym: "absent galactocerebroside beta-galactosidase protein" EXACT []
synonym: "absent galactocerebroside galactosidase protein" EXACT []
synonym: "absent galactocerebroside-beta-D-galactosidase protein" EXACT []
synonym: "absent galactosylceramidase I protein" EXACT []
synonym: "absent galactosylceramide beta-galactosidase protein" EXACT []
synonym: "absent galactosylcerebrosidase protein" EXACT []
synonym: "absent galcerase protein" EXACT []
synonym: "absent lactosylceramidase I protein" EXACT []
synonym: "absent lactosylceramidase protein" EXACT []
is_a: MP:0020265 ! decreased galactosylceramidase level

[Term]
id: MP:0020267
name: abnormal beta-mannosidase level
def: "abnormal level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides" [https://orcid.org/0000-0001-5208-3432, PMID:7876128]
synonym: "abnormal beta-D-mannosidase level" EXACT []
synonym: "abnormal beta-D-mannoside mannohydrolase level" EXACT []
synonym: "abnormal beta-mannoside mannohydrolase level" EXACT []
synonym: "abnormal exo-beta-D-mannanase level" EXACT []
synonym: "abnormal mannanase level" EXACT []
synonym: "abnormal mannase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020268
name: increased beta-mannosidase level
def: "increased level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides" [https://orcid.org/0000-0001-5208-3432, PMID:7876128]
synonym: "increased beta-D-mannosidase level" EXACT []
synonym: "increased beta-D-mannoside mannohydrolase level" EXACT []
synonym: "increased beta-mannoside mannohydrolase level" EXACT []
synonym: "increased exo-beta-D-mannanase level" EXACT []
synonym: "increased mannanase level" EXACT []
synonym: "increased mannase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020267 ! abnormal beta-mannosidase level

[Term]
id: MP:0020269
name: decreased beta-mannosidase level
def: "decreased level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides" [https://orcid.org/0000-0001-5208-3432, PMID:7876128]
synonym: "decreased beta-D-mannosidase level" EXACT []
synonym: "decreased beta-D-mannoside mannohydrolase level" EXACT []
synonym: "decreased beta-mannoside mannohydrolase level" EXACT []
synonym: "decreased exo-beta-D-mannanase level" EXACT []
synonym: "decreased mannanase level" EXACT []
synonym: "decreased mannase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020267 ! abnormal beta-mannosidase level

[Term]
id: MP:0020270
name: abnormal branched-chain alpha-keto acid dehydrogenase level
def: "abnormal level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids" [https://orcid.org/0000-0001-5208-3432, PMID:3597778]
synonym: "abnormal 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex level" EXACT []
synonym: "abnormal BCADH level" EXACT []
synonym: "abnormal BCKADH level" EXACT []
synonym: "abnormal branched-chain alpha-ketoacid dehydrogenase complex level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020271
name: increased branched-chain alpha-keto acid dehydrogenase level
def: "increased level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids" [https://orcid.org/0000-0001-5208-3432, PMID:3597778]
synonym: "increased 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex level" EXACT []
synonym: "increased BCADH level" EXACT []
synonym: "increased BCKADH level" EXACT []
synonym: "increased branched-chain alpha-ketoacid dehydrogenase complex level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020270 ! abnormal branched-chain alpha-keto acid dehydrogenase level

[Term]
id: MP:0020272
name: decreased branched-chain alpha-keto acid dehydrogenase level
def: "decreased level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids" [https://orcid.org/0000-0001-5208-3432, PMID:3597778]
synonym: "decreased 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex level" EXACT []
synonym: "decreased BCADH level" EXACT []
synonym: "decreased BCKADH level" EXACT []
synonym: "decreased branched-chain alpha-ketoacid dehydrogenase complex level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020270 ! abnormal branched-chain alpha-keto acid dehydrogenase level

[Term]
id: MP:0020273
name: abnormal N-acetylgalactosamine-4-sulfatase level
def: "abnormal level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate" [GO:0003943, https://orcid.org/0000-0001-5208-3432]
synonym: "abnormal acetylgalactosamine 4-sulfatase level" EXACT []
synonym: "abnormal arylsulfatase B level" EXACT []
synonym: "abnormal chondroitinsulfatase level" EXACT []
synonym: "abnormal N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase level" EXACT []
synonym: "abnormal N-acetylgalactosamine 4-sulfate sulfohydrolase level" EXACT []
synonym: "abnormal N-acetylgalactosamine-4-sulphatase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020274
name: increased N-acetylgalactosamine-4-sulfatase protein level
def: "increased level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate" [GO:0003943, https://orcid.org/0000-0001-5208-3432]
synonym: "increased acetylgalactosamine 4-sulfatase level" EXACT []
synonym: "increased arylsulfatase B level" EXACT []
synonym: "increased chondroitinsulfatase level" EXACT []
synonym: "increased N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase level" EXACT []
synonym: "increased N-acetylgalactosamine 4-sulfate sulfohydrolase level" EXACT []
synonym: "increased N-acetylgalactosamine-4-sulphatase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020273 ! abnormal N-acetylgalactosamine-4-sulfatase level

[Term]
id: MP:0020275
name: decreased N-acetylgalactosamine-4-sulfatase protein level
def: "decreased level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate" [GO:0003943, https://orcid.org/0000-0001-5208-3432]
synonym: "decreased acetylgalactosamine 4-sulfatase level" EXACT []
synonym: "decreased arylsulfatase B level" EXACT []
synonym: "decreased chondroitinsulfatase level" EXACT []
synonym: "decreased N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase level" EXACT []
synonym: "decreased N-acetylgalactosamine 4-sulfate sulfohydrolase level" EXACT []
synonym: "decreased N-acetylgalactosamine-4-sulphatase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020273 ! abnormal N-acetylgalactosamine-4-sulfatase level

[Term]
id: MP:0020276
name: abnormal glycogen debranching enzyme level
def: "abnormal level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver" [https://orcid.org/0000-0001-5208-3432, PMID:6078537]
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020277
name: increased glycogen debranching enzyme level
def: "increased level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver" [https://orcid.org/0000-0001-5208-3432, PMID:6078537]
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020276 ! abnormal glycogen debranching enzyme level

[Term]
id: MP:0020278
name: decreased glycogen debranching enzyme level
def: "decreased level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver" [https://orcid.org/0000-0001-5208-3432, PMID:6078537]
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020276 ! abnormal glycogen debranching enzyme level

[Term]
id: MP:0020279
name: abnormal creatine kinase level
def: "abnormal level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0001-5208-3432, MP:0010089]
synonym: "abnormal adenosine triphosphate-creatine transphosphorylase level" EXACT []
synonym: "abnormal ATP:creatine N-phosphotransferase level" EXACT []
synonym: "abnormal ATP:creatine phosphotransferase level" EXACT []
synonym: "abnormal BB-CK level" EXACT []
synonym: "abnormal CK level" EXACT []
synonym: "abnormal CK-BB level" EXACT []
synonym: "abnormal CK-MB level" EXACT []
synonym: "abnormal CK-MM level" EXACT []
synonym: "abnormal CKMiMi level" EXACT []
synonym: "abnormal creatine phosphokinase level" EXACT []
synonym: "abnormal creatine phosphotransferase level" EXACT []
synonym: "abnormal MB-CK level" EXACT []
synonym: "abnormal Mi-CK level" EXACT []
synonym: "abnormal MiMi-CK level" EXACT []
synonym: "abnormal MM-CK level" EXACT []
synonym: "abnormal phosphocreatine kinase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020280
name: increased creatine kinase level
def: "increased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0001-5208-3432, MP:0010089]
synonym: "increased adenosine triphosphate-creatine transphosphorylase level" EXACT []
synonym: "increased ATP:creatine N-phosphotransferase level" EXACT []
synonym: "increased ATP:creatine phosphotransferase level" EXACT []
synonym: "increased BB-CK" EXACT []
synonym: "increased CK" EXACT []
synonym: "increased CK-BB" EXACT []
synonym: "increased CK-MB" EXACT []
synonym: "increased CK-MM" EXACT []
synonym: "increased CKMiMi" EXACT []
synonym: "increased creatine phosphokinase level" EXACT []
synonym: "increased creatine phosphotransferase level" EXACT []
synonym: "increased MB-CK" EXACT []
synonym: "increased Mi-CK" EXACT []
synonym: "increased MiMi-CK" EXACT []
synonym: "increased MM-CK" EXACT []
synonym: "increased phosphocreatine kinase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020279 ! abnormal creatine kinase level

[Term]
id: MP:0020281
name: decreased creatine kinase level
def: "decreased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [https://orcid.org/0000-0001-5208-3432, MP:0010089]
synonym: "decreased adenosine triphosphate-creatine transphosphorylase level" EXACT []
synonym: "decreased ATP:creatine N-phosphotransferase level" EXACT []
synonym: "decreased ATP:creatine phosphotransferase level" EXACT []
synonym: "decreased BB-CK" EXACT []
synonym: "decreased CK" EXACT []
synonym: "decreased CK-BB" EXACT []
synonym: "decreased CK-MB" EXACT []
synonym: "decreased CK-MM" EXACT []
synonym: "decreased CKMiMi" EXACT []
synonym: "decreased creatine phosphokinase level" EXACT []
synonym: "decreased creatine phosphotransferase level" EXACT []
synonym: "decreased MB-CK" EXACT []
synonym: "decreased Mi-CK" EXACT []
synonym: "decreased MiMi-CK" EXACT []
synonym: "decreased MM-CK" EXACT []
synonym: "decreased phosphocreatine kinase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020279 ! abnormal creatine kinase level

[Term]
id: MP:0020282
name: abnormal hydroxymethylbilane synthase level
def: "abnormal level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules" [https://orcid.org/0000-0001-5208-3432, PMID:2609111]
synonym: "abnormal (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) level" EXACT []
synonym: "abnormal (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "abnormal HMB synthase level" EXACT []
synonym: "abnormal HMB-synthase level" EXACT []
synonym: "abnormal porphobilinogen ammonia-lyase (polymerizing) level" EXACT []
synonym: "abnormal porphobilinogen deaminase level" EXACT []
synonym: "abnormal porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "abnormal pre-uroporphyrinogen synthase level" EXACT []
synonym: "abnormal uroporphyrinogen I synthase level" EXACT []
synonym: "abnormal uroporphyrinogen I synthetase level" EXACT []
synonym: "abnormal uroporphyrinogen synthase level" EXACT []
synonym: "abnormal uroporphyrinogen synthetase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020283
name: increased hydroxymethylbilane synthase level
def: "increased level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules" [https://orcid.org/0000-0001-5208-3432, PMID:2609111]
synonym: "increased (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) level" EXACT []
synonym: "increased (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "increased HMB synthase level" EXACT []
synonym: "increased HMB-synthase level" EXACT []
synonym: "increased porphobilinogen ammonia-lyase (polymerizing) level" EXACT []
synonym: "increased porphobilinogen deaminase level" EXACT []
synonym: "increased porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "increased pre-uroporphyrinogen synthase level" EXACT []
synonym: "increased uroporphyrinogen I synthase level" EXACT []
synonym: "increased uroporphyrinogen I synthetase level" EXACT []
synonym: "increased uroporphyrinogen synthase level" EXACT []
synonym: "increased uroporphyrinogen synthetase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020282 ! abnormal hydroxymethylbilane synthase level

[Term]
id: MP:0020284
name: decreased hydroxymethylbilane synthase level
def: "decreased level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules" [https://orcid.org/0000-0001-5208-3432, PMID:2609111]
synonym: "decreased (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) level" EXACT []
synonym: "decreased (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "decreased HMB synthase level" EXACT []
synonym: "decreased HMB-synthase level" EXACT []
synonym: "decreased porphobilinogen ammonia-lyase (polymerizing) level" EXACT []
synonym: "decreased porphobilinogen deaminase level" EXACT []
synonym: "decreased porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) level" EXACT []
synonym: "decreased pre-uroporphyrinogen synthase level" EXACT []
synonym: "decreased uroporphyrinogen I synthase level" EXACT []
synonym: "decreased uroporphyrinogen I synthetase level" EXACT []
synonym: "decreased uroporphyrinogen synthase level" EXACT []
synonym: "decreased uroporphyrinogen synthetase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020282 ! abnormal hydroxymethylbilane synthase level

[Term]
id: MP:0020285
name: abnormal palmitoyl-(protein) hydrolase level
def: "abnomal level of the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation" [https://orcid.org/0000-0001-5208-3432, PMID:7637805]
synonym: "abnormal palmitoyl protein thioesterase protein" EXACT []
synonym: "abnormal palmitoyl-[protein] hydrolase level" EXACT []
synonym: "abnormal palmitoyl-protein hydrolase level" EXACT []
synonym: "abnormal palmitoyl-protein thioesterase level" EXACT []
synonym: "abnormal palmitoyl-protein thiolesterase level" EXACT []
synonym: "abnormal PPT1 protein" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level

[Term]
id: MP:0020286
name: increased palmitoyl-(protein) hydrolase level
def: "increased level fo the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation" [https://orcid.org/0000-0001-5208-3432, PMID:7637805]
synonym: "increased palmitoyl protein thioesterase protein" EXACT []
synonym: "increased palmitoyl-[protein] hydrolase level" EXACT []
synonym: "increased palmitoyl-protein hydrolase level" EXACT []
synonym: "increased palmitoyl-protein thioesterase level" EXACT []
synonym: "increased palmitoyl-protein thiolesterase level" EXACT []
synonym: "increased PPT1 protein" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0020285 ! abnormal palmitoyl-(protein) hydrolase level

[Term]
id: MP:0020287
name: decreased palmitoyl-(protein) hydrolase level
def: "reduced level fo the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation" [https://orcid.org/0000-0001-5208-3432, PMID:7637805]
synonym: "decreased palmitoyl protein thioesterase protein" EXACT []
synonym: "decreased palmitoyl-[protein] hydrolase level" EXACT []
synonym: "decreased palmitoyl-protein hydrolase level" EXACT []
synonym: "decreased palmitoyl-protein thioesterase level" EXACT []
synonym: "decreased palmitoyl-protein thiolesterase level" EXACT []
synonym: "decreased PPT1 protein" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0020285 ! abnormal palmitoyl-(protein) hydrolase level

[Term]
id: MP:0020288
name: ectopic limbs
def: "more than the expected number of limbs differentiate during early embryogenesis" [https://orcid.org/0000-0001-5208-3432]
synonym: "polymelia" EXACT []
synonym: "supernumerary limbs" EXACT []
is_a: MP:0002109 ! abnormal limb morphology

[Term]
id: MP:0020289
name: astasia
def: "the inability to stand due to muscular incoordination" [http://medical-dictionary.thefreedictionary.com/astasia, https://orcid.org/0000-0001-5208-3432]
synonym: "impaired ability to rise" EXACT []
synonym: "impaired ability to stand up" EXACT []
synonym: "inability to rise" EXACT []
is_a: MP:0003312 ! abnormal locomotor coordination

[Term]
id: MP:0020290
name: floppy ears
def: "ears that are limp or hanging loosely" [http://www.thefreedictionary.com/floppy, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0002177 ! abnormal outer ear morphology

[Term]
id: MP:0020291
name: abnormal dystrophin level
def: "deviation from the normal level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane" [https://orcid.org/0000-0001-5208-3432, PMID:7719347]
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0020292
name: decreased dystrophin level
def: "reduced level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane" [https://orcid.org/0000-0001-5208-3432, PMID:7719347]
is_a: MP:0020291 ! abnormal dystrophin level

[Term]
id: MP:0020293
name: increased dystrophin level
def: "greater level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane" [https://orcid.org/0000-0001-5208-3432, PMID:7719347]
is_a: MP:0020291 ! abnormal dystrophin level

[Term]
id: MP:0020294
name: abnormal guanylate cyclase activating protein-2 level
def: "abnormal level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins" [https://orcid.org/0000-0001-5208-3432, PMID:23082185]
synonym: "abnormal GCAP2 level" EXACT []
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0020295
name: decreased guanylate cyclase activating protein-2 level
def: "decreased level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins" [https://orcid.org/0000-0001-5208-3432, PMID:23082185]
synonym: "decreased GCAP2 level" EXACT []
is_a: MP:0020294 ! abnormal guanylate cyclase activating protein-2 level

[Term]
id: MP:0020296
name: increased guanylate cyclase activating protein-2 level
def: "increased level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins" [https://orcid.org/0000-0001-5208-3432, PMID:23082185]
synonym: "increased GCAP2 level" EXACT []
is_a: MP:0020294 ! abnormal guanylate cyclase activating protein-2 level

[Term]
id: MP:0020297
name: abnormal UDP-N-acetylglucosamine-1-phosphotransferase level
def: "abnormal level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose" [https://orcid.org/0000-0001-5208-3432, PMID:6452459]
synonym: "abnormal GlcNAc-phosphotransferase level" EXACT []
is_a: MP:0008469 ! abnormal protein level

[Term]
id: MP:0020298
name: decreased UDP-N-acetylglucosamine-1-phosphotransferase level
def: "decreased level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose" [https://orcid.org/0000-0001-5208-3432, PMID:6452459]
synonym: "decreased GlcNAc-phosphotransferase level" EXACT []
is_a: MP:0020297 ! abnormal UDP-N-acetylglucosamine-1-phosphotransferase level

[Term]
id: MP:0020299
name: increased UDP-N-acetylglucosamine-1-phosphotransferase level
def: "increased level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose" [https://orcid.org/0000-0001-5208-3432, PMID:6452459]
synonym: "increased GlcNAc-phosphotransferase level" EXACT []
is_a: MP:0020297 ! abnormal UDP-N-acetylglucosamine-1-phosphotransferase level

[Term]
id: MP:0020300
name: long tongue
def: "increased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [https://orcid.org/0000-0001-5208-3432]
synonym: "increased tongue length" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0020301
name: short tongue
def: "decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [https://orcid.org/0000-0001-5208-3432]
synonym: "decreased tongue length" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology

[Term]
id: MP:0020302
name: large horns
def: "increased size of the one or more of the hard pointed parts that grows on the head of some animals" [http://www.merriam-webster.com/dictionary/horn, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020304 ! abnormal horn morphology

[Term]
id: MP:0020303
name: small horns
def: "decreased size of the one or more of the hard pointed parts that grows on the head of some animals" [http://www.merriam-webster.com/dictionary/horn, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0020304 ! abnormal horn morphology

[Term]
id: MP:0020304
name: abnormal horn morphology
def: "any structural anomaly of the hard pointed parts that grows on the head of some animals" [http://www.merriam-webster.com/dictionary/horn, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0000432 ! abnormal head morphology

[Term]
id: MP:0020305
name: abnormal horn pigmentation
def: "irregular or unusual pigmentation of the hard pointed parts that grows on the head of some animals" [http://www.merriam-webster.com/dictionary/horn, https://orcid.org/0000-0001-5208-3432]
is_a: MP:0001186 ! pigmentation phenotype
is_a: MP:0020304 ! abnormal horn morphology

[Term]
id: MP:0020306
name: absent horns
def: "lack of the hard pointed parts that grows on the head of some animals" [http://www.merriam-webster.com/dictionary/horn, https://orcid.org/0000-0001-5208-3432]
synonym: "polledness" EXACT []
is_a: MP:0020304 ! abnormal horn morphology

[Term]
id: MP:0020307
name: abnormal creatine kinase activity
def: "altered ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [https://orcid.org/0000-0001-5208-3432, PMID:18977227]
synonym: "abnormal adenosine triphosphate-creatine transphosphorylase activity" EXACT []
synonym: "abnormal ATP:creatine N-phosphotransferase activity" EXACT []
synonym: "abnormal ATP:creatine phosphotransferase activity" EXACT []
synonym: "abnormal BB-CK activity" EXACT []
synonym: "abnormal CK activity" EXACT []
synonym: "abnormal CK-BB activity" EXACT []
synonym: "abnormal CK-MB activity" EXACT []
synonym: "abnormal CK-MM activity" EXACT []
synonym: "abnormal CKMiMi activity" EXACT []
synonym: "abnormal creatine phosphokinase activity" EXACT []
synonym: "abnormal creatine phosphotransferase activity" EXACT []
synonym: "abnormal MB-CK activity" EXACT []
synonym: "abnormal Mi-CK activity" EXACT []
synonym: "abnormal MiMi-CK activity" EXACT []
synonym: "abnormal MM-CK activity" EXACT []
synonym: "abnormal phosphocreatine kinase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0020308
name: decreased creatine kinase activity
def: "reduced ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [https://orcid.org/0000-0001-5208-3432, PMID:18977227]
synonym: "decreased adenosine triphosphate-creatine transphosphorylase activity" EXACT []
synonym: "decreased ATP:creatine N-phosphotransferase activity" EXACT []
synonym: "decreased ATP:creatine phosphotransferase activity" EXACT []
synonym: "decreased BB-CK actvity" EXACT []
synonym: "decreased CK actvity" EXACT []
synonym: "decreased CK-BB actvity" EXACT []
synonym: "decreased CK-MB actvity" EXACT []
synonym: "decreased CK-MM actvity" EXACT []
synonym: "decreased CKMiMi actvity" EXACT []
synonym: "decreased creatine phosphokinase activity" EXACT []
synonym: "decreased creatine phosphotransferase activity" EXACT []
synonym: "decreased MB-CK actvity" EXACT []
synonym: "decreased Mi-CK actvity" EXACT []
synonym: "decreased MiMi-CK actvity" EXACT []
synonym: "decreased MM-CK actvity" EXACT []
synonym: "decreased phosphocreatine kinase activity" EXACT []
is_a: MP:0020307 ! abnormal creatine kinase activity

[Term]
id: MP:0020309
name: increased creatine kinase activity
def: "increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [https://orcid.org/0000-0001-5208-3432, PMID:18977227]
synonym: "increased adenosine triphosphate-creatine transphosphorylase activity" EXACT []
synonym: "increased ATP:creatine N-phosphotransferase activity" EXACT []
synonym: "increased ATP:creatine phosphotransferase activity" EXACT []
synonym: "increased BB-CK activity" EXACT []
synonym: "increased CK activity" EXACT []
synonym: "increased CK-BB actvity" EXACT []
synonym: "increased CK-MB actvity" EXACT []
synonym: "increased CK-MM actvity" EXACT []
synonym: "increased CKMiMi actvity" EXACT []
synonym: "increased creatine phosphokinase activity" EXACT []
synonym: "increased creatine phosphotransferase activity" EXACT []
synonym: "increased MB-CK actvity" EXACT []
synonym: "increased Mi-CK actvity" EXACT []
synonym: "increased MiMi-CK actvity" EXACT []
synonym: "increased MM-CK actvity" EXACT []
synonym: "increased phosphocreatine kinase activity" EXACT []
is_a: MP:0020307 ! abnormal creatine kinase activity

[Term]
id: MP:0020310
name: abnormal hydroxymethylbilane synthase activity
def: "altered ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [https://orcid.org/0000-0001-5208-3432, PMID:6615434]
synonym: "abnormal (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT []
synonym: "abnormal (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "abnormal HMB synthase activity" EXACT []
synonym: "abnormal HMB-synthase activity" EXACT []
synonym: "abnormal porphobilinogen ammonia-lyase (polymerizing)" EXACT []
synonym: "abnormal porphobilinogen deaminase activity" EXACT []
synonym: "abnormal porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "abnormal pre-uroporphyrinogen synthase activity" EXACT []
synonym: "abnormal uroporphyrinogen I synthase activity" EXACT []
synonym: "abnormal uroporphyrinogen I synthetase activity" EXACT []
synonym: "abnormal uroporphyrinogen synthase activity" EXACT []
synonym: "abnormal uroporphyrinogen synthetase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0020311
name: decreased hydroxymethylbilane synthase activity
def: "reduced ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [https://orcid.org/0000-0001-5208-3432, PMID:6615434]
synonym: "decreased (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT []
synonym: "decreased (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "decreased HMB synthase activity" EXACT []
synonym: "decreased HMB-synthase activity" EXACT []
synonym: "decreased porphobilinogen ammonia-lyase (polymerizing)" EXACT []
synonym: "decreased porphobilinogen deaminase activity" EXACT []
synonym: "decreased porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "decreased pre-uroporphyrinogen synthase activity" EXACT []
synonym: "decreased uroporphyrinogen I synthase activity" EXACT []
synonym: "decreased uroporphyrinogen I synthetase activity" EXACT []
synonym: "decreased uroporphyrinogen synthase activity" EXACT []
synonym: "decreased uroporphyrinogen synthetase activity" EXACT []
is_a: MP:0020310 ! abnormal hydroxymethylbilane synthase activity

[Term]
id: MP:0020312
name: increased hydroxymethylbilane synthase activity
def: "increased ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [https://orcid.org/0000-0001-5208-3432, PMID:6615434]
synonym: "increased (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT []
synonym: "increased (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "increased HMB synthase activity" EXACT []
synonym: "increased HMB-synthase activity" EXACT []
synonym: "increased porphobilinogen ammonia-lyase (polymerizing)" EXACT []
synonym: "increased porphobilinogen deaminase activity" EXACT []
synonym: "increased porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT []
synonym: "increased pre-uroporphyrinogen synthase activity" EXACT []
synonym: "increased uroporphyrinogen I synthase activity" EXACT []
synonym: "increased uroporphyrinogen I synthetase activity" EXACT []
synonym: "increased uroporphyrinogen synthase activity" EXACT []
synonym: "increased uroporphyrinogen synthetase activity" EXACT []
is_a: MP:0020310 ! abnormal hydroxymethylbilane synthase activity

[Term]
id: MP:0020313
name: abnormal palmitoyl-(protein) hydrolase activity
def: "altered ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein." [https://orcid.org/0000-0001-5208-3432, PMID:7651163]
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity

[Term]
id: MP:0020314
name: decreased palmitoyl-(protein) hydrolase activity
def: "reduced ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein." [https://orcid.org/0000-0001-5208-3432, PMID:7651163]
synonym: "decreased palmitoyl-[protein] hydrolase activity" EXACT []
synonym: "decreased palmitoyl-protein hydrolase activity" EXACT []
synonym: "decreased palmitoyl-protein thioesterase activity" EXACT []
synonym: "decreased palmitoyl-protein thiolesterase activity" EXACT []
is_a: MP:0020313 ! abnormal palmitoyl-(protein) hydrolase activity

[Term]
id: MP:0020315
name: increased palmitoyl-(protein) hydrolase activity
def: "increased ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein." [https://orcid.org/0000-0001-5208-3432, PMID:7651163]
synonym: "increased palmitoyl-[protein] hydrolase" EXACT []
synonym: "increased palmitoyl-protein hydrolase activity" EXACT []
synonym: "increased palmitoyl-protein thioesterase activity" EXACT []
synonym: "increased palmitoyl-protein thiolesterase activity" EXACT []
is_a: MP:0020313 ! abnormal palmitoyl-(protein) hydrolase activity

[Term]
id: MP:0020316
name: decreased vascular endothelial cell proliferation
def: "decrease in the expansion rate of any vascular endothelial cell population by cell division" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0020146 ! abnormal vascular endothelial cell proliferation

[Term]
id: MP:0020317
name: abnormal vascular endothelial cell adhesion
def: "altered ability of an endothelial cell in the vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003566 ! abnormal cell adhesion
is_a: MP:0004003 ! abnormal vascular endothelial cell physiology

[Term]
id: MP:0020318
name: increased vascular endothelial cell adhesion
def: "greater than expected ability of an endothelial cell in the vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020317 ! abnormal vascular endothelial cell adhesion

[Term]
id: MP:0020319
name: decreased vascular endothelial cell adhesion
def: "less than expected ability of an endothelial cell in the vasculature to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020317 ! abnormal vascular endothelial cell adhesion

[Term]
id: MP:0020320
name: abnormal vascular endothelial cell apoptosis
def: "change in the timing or the number of vascular endothelial cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0004003 ! abnormal vascular endothelial cell physiology

[Term]
id: MP:0020321
name: increased vascular endothelial cell apoptosis
def: "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020320 ! abnormal vascular endothelial cell apoptosis

[Term]
id: MP:0020322
name: decreased vascular endothelial cell apoptosis
def: "decrease in the timing or the number of vascular endothelial cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020320 ! abnormal vascular endothelial cell apoptosis

[Term]
id: MP:0020323
name: abnormal heart apex size
def: "any anomaly in the proportions  of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012515 ! abnormal heart apex morphology

[Term]
id: MP:0020324
name: jejunum polyps
def: "development of numerous growths that are connected to and protrude from the mucous membrane of the jejunum" [https://orcid.org/0000-0003-4606-0597, PMID:25578479]
synonym: "jejunal polyposis" EXACT []
synonym: "jejunal polyps" EXACT []
synonym: "jejunum polyposis" EXACT []
is_a: MP:0004002 ! abnormal jejunum morphology
is_a: MP:0008011 ! intestine polyps

[Term]
id: MP:0020325
name: abnormal beige fat cell morphology
def: "any structural anomaly of fat cells that are beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor" [CL_0001070, https://orcid.org/0000-0003-4606-0597, PMID:22796012, PMID:23603813, PMID:24575370]
synonym: "abnormal beige adipocyte morphology" EXACT []
synonym: "abnormal beige brown adipocyte morphology" EXACT []
synonym: "abnormal brite adipocyte morphology" EXACT []
synonym: "abnormal brite cell morphology" EXACT []
synonym: "abnormal brite fat cell morphology" EXACT []
is_a: MP:0009115 ! abnormal fat cell morphology

[Term]
id: MP:0020326
name: dilated capillary
def: "stretched or widened aperture of the luminal space of one or more of the small branching blood vessels that form a network between the arterioles and venules" [https://orcid.org/0000-0003-4606-0597]
synonym: "capillary dilation" EXACT []
synonym: "dilated capillaries" EXACT []
is_a: MP:0003658 ! abnormal capillary morphology
is_a: MP:0004938 ! dilated vasculature

[Term]
id: MP:0020327
name: abnormal capillary branching pattern
def: "any changes in the placement, morphology or number of divisions of the capillaries" [https://orcid.org/0000-0003-4606-0597, PMID:14713950]
is_a: MP:0003658 ! abnormal capillary morphology

[Term]
id: MP:0020328
name: abnormal capillary density
def: "any anomaly in the number of capillaries in a given cross-sectional area of a tissue" [https://orcid.org/0000-0003-4606-0597, PMID:20944627]
is_a: MP:0003658 ! abnormal capillary morphology

[Term]
id: MP:0020329
name: decreased capillary density
def: "reduction in the number of capillaries in a given cross-sectional area of a tissue" [https://orcid.org/0000-0003-4606-0597, PMID:20944627]
is_a: MP:0020328 ! abnormal capillary density

[Term]
id: MP:0020330
name: increased capillary density
def: "increase in the number of capillaries in a given cross-sectional area of a tissue" [https://orcid.org/0000-0003-4606-0597, PMID:20705734]
is_a: MP:0020328 ! abnormal capillary density

[Term]
id: MP:0020331
name: increased capillary tortuosity
def: "increase in the degree of twisting of capillaries" [https://orcid.org/0000-0003-4606-0597, PMCID:PMC3369246]
synonym: "tortuous capillaries" EXACT []
is_a: MP:0003658 ! abnormal capillary morphology

[Term]
id: MP:0020332
name: impaired leukocyte tethering or rolling
def: "reduced ability or inability  in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, https://orcid.org/0000-0003-4606-0597]
synonym: "impaired leucocyte tethering or rolling" EXACT []
is_a: MP:0003627 ! abnormal leukocyte tethering or rolling

[Term]
id: MP:0020333
name: enhanced leukocyte tethering or rolling
def: "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced leucocyte tethering or rolling" EXACT []
is_a: MP:0003627 ! abnormal leukocyte tethering or rolling

[Term]
id: MP:0020334
name: abnormal melanophage morphology
def: "any structural anomaly in the  melanin-containing macrophages that obtain the pigment by phagocytosis of melanosomes" [CL_0002060, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002446 ! abnormal macrophage morphology

[Term]
id: MP:0020335
name: abnormal dentate gyrus neuron dendrite morphology
def: "any structural anomaly of the highly branched tree-like process of a neuron in one of two interlocking gyri of the hippocampus formation" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008143 ! abnormal dendrite morphology

[Term]
id: MP:0020336
name: abnormal motor neuron dendrite morphology
def: "any structural anomaly of the highly branched tree-like process of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008143 ! abnormal dendrite morphology

[Term]
id: MP:0020337
name: abnormal pyramidal neuron dendrite morphology
def: "structural anomaly of the highly branched tree-like process of the neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_0000598, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008143 ! abnormal dendrite morphology

[Term]
id: MP:0020338
name: abnormal hippocampal pyramidal neuron dendrite morphology
def: "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020337 ! abnormal pyramidal neuron dendrite morphology

[Term]
id: MP:0020339
name: abnormal retina ganglion cell dendrite morphology
def: "any structural anomaly of the highly branched tree-like process of neurons in the retina that receive neural inputs via bipolar, horizontal and amacrine cells" [CL_0000740, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal retinal ganglion cell dendrite morphology" EXACT []
is_a: MP:0008143 ! abnormal dendrite morphology

[Term]
id: MP:0020340
name: abnormal inhibitory learning
def: "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, https://orcid.org/0000-0003-4606-0597, PMID:19321764]
synonym: "abnormal latent inhibition of learned behavior" EXACT []
is_a: MP:0002063 ! abnormal learning/memory/conditioning

[Term]
id: MP:0020341
name: abnormal circulating hyaluronic acid level
def: "any anomaly in the amount in the blood of hyaluronic acid, an anionic nonsulfated glycosaminoglycan containing the constituent sugars: glucuronic acid and glucosamine" [https://orcid.org/0000-0003-4606-0597, PMID:9260563]
synonym: "abnormal circulating hyaluronan level" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis
is_a: MP:0014426 ! abnormal hyaluronic acid level

[Term]
id: MP:0020342
name: small optic nerve
def: "decreased size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies" [ORCID:orcid.org/0000-0003-3691-0324]
synonym: "decreased optic nerve size" EXACT []
synonym: "reduced optic nerve size" EXACT []
is_a: MP:0001330 ! abnormal optic nerve morphology

[Term]
id: MP:0020343
name: abnormal ureteric bud number
def: "anomaly in the number of the epithelial swelling on the metanephric duct that elongates to invade the adjacent metanephric mesenchyme" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal mesonephric diverticulum number" EXACT []
is_a: MP:0006032 ! abnormal ureteric bud morphology

[Term]
id: MP:0020344
name: abnormal susceptibility to injury induced morbidity/mortality
def: "differences from the expected moribund state caused by trauma, especially that by physical means" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal resistance to injury induced morbidity/mortality" EXACT []
synonym: "abnormal sensitivity to injury induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0005164 ! abnormal response to injury

[Term]
id: MP:0020345
name: abnormal myocardial fiber currents
def: "any anomaly in the electrical currents produced by cardiac ion channels, typically measured using  whole-cell patch-clamp techniques" [http://www.ncbi.nlm.nih.gov/books/NBK7515/, PMID:21372286, PMID:25368181]
synonym: "abnormal cardiomyocyte currents" EXACT []
synonym: "abnormal myocardial fibre currents" EXACT []
is_a: MP:0004215 ! abnormal myocardial fiber physiology

[Term]
id: MP:0020346
name: abnormal myocardial fiber calcium currents
def: "any anomaly in the electrical currents produced by cardiac calcium ion channels, typically measured using  whole-cell patch-clamp techniques" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cardiomyocyte calcium currents" EXACT []
is_a: MP:0020345 ! abnormal myocardial fiber currents

[Term]
id: MP:0020347
name: abnormal myocardial fiber sodium currents
def: "any anomaly in the electrical currents produced by cardiac sodium ion channels, typically measured using  whole-cell patch-clamp techniques" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cardiomyocyte sodium currents" EXACT []
is_a: MP:0020345 ! abnormal myocardial fiber currents

[Term]
id: MP:0020348
name: decreased olfactory sensory neuron number
def: "decreased number of the neurons in the olfactory epithelium that are activated by specific odorants" [https://orcid.org/0000-0003-4606-0597, MGI:mberry]
synonym: "decreased olfactory receptor neuron number" EXACT []
is_a: MP:0000966 ! decreased sensory neuron number
is_a: MP:0006092 ! abnormal olfactory sensory neuron morphology

[Term]
id: MP:0020349
name: abnormal dendritic cell migration
def: "any anomaly in the movement of dendritic cells from one site to another" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002376 ! abnormal dendritic cell physiology
is_a: MP:0003156 ! abnormal leukocyte migration

[Term]
id: MP:0020350
name: fused pharyngeal arches
def: "failure of two or more pharyngeal arches to fully separate" [https://orcid.org/0000-0003-4606-0597, PMID:22319578]
synonym: "fused branchial arches" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology

[Term]
id: MP:0020351
name: decreased vocalization
def: "decrease in the production of vocal sound" [https://orcid.org/0000-0003-4606-0597, PMID:26621702]
synonym: "reduced vocalization" EXACT []
is_a: MP:0001529 ! abnormal vocalization

[Term]
id: MP:0020352
name: abnormal endoplasmic reticulum physiology
def: "any functional anomaly of the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal ER physiology" EXACT []
is_a: MP:0014241 ! abnormal intracellular organelle physiology

[Term]
id: MP:0020353
name: abnormal endoplasmic reticulum stress
def: "any anomaly in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation maybe stimulated by genetic or enviromental factors" [https://orcid.org/0000-0003-4606-0597, PMID:21266244]
synonym: "abnormal ER stress" EXACT []
is_a: MP:0020352 ! abnormal endoplasmic reticulum physiology

[Term]
id: MP:0020354
name: increased endoplasmic reticulum stress
def: "increase in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or environmental factors" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced ER stress" EXACT []
synonym: "increased ER stress" EXACT []
is_a: MP:0020353 ! abnormal endoplasmic reticulum stress

[Term]
id: MP:0020355
name: abnormal Sertoli cell barrier morphology
def: "any structural anomaly of the physical barrier found between adjacent Sertoli cells within the seminiferous tubules; the sertoli cell barrier consists of several types of cellular junctions including tight junctions, gap junctions and adhesion junctions, and divides the seminiferous tubules into the basal and apical (adluminal) compartments" [PMID:24713828]
synonym: "abnormal blood-testis barrier morphology" EXACT []
synonym: "abnormal BTB morphology" EXACT []
synonym: "abnormal SCB morphology" EXACT []
is_a: MP:0011750 ! abnormal seminiferous tubule epithelium morphology

[Term]
id: MP:0020356
name: abnormal Sertoli cell barrier function
def: "any functional anomaly of the physical barrier found between the blood vessels and the seminiferous tubules of the testes; this barrier between Sertoli cells is composed of  tight junctions, basal ectoplasmic specializations, and desmosome-like junctions" [https://en.wikipedia.org/wiki/Blood%E2%80%93testis_barrier, PMID:24713828, PMID:24803656]
synonym: "abnormal blood-testis barrier function" EXACT []
synonym: "abnormal BTB function" EXACT []
synonym: "abnormal SCB function" EXACT []
is_a: MP:0004884 ! abnormal testis physiology

[Term]
id: MP:0020357
name: abnormal excitatory synapse morphology
def: "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0020358
name: abnormal inhibitory synapse morphology
def: "any structural anomaly in a synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell" [GO:0060077]
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0020359
name: abnormal ribbon synapse morphology
def: "any structural anomaly in a synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm" [GO:0097470]
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0020360
name: abnormal asymmetric synapse morphology
def: "any structural anomaly in a type of synapse occurring between an axon and a dendritic spine or dendritic shaft; asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density" [GO:0032279]
synonym: "abnormal Gray's type I synapse morphology" EXACT []
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0020361
name: abnormal symmetric synapse morphology
def: "any structurla anomaly in  synapse that lacks an electron dense postsynaptic specialization; in vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory" [GO:0032280]
synonym: "abnormal Gray's type II synapse morphology" EXACT []
is_a: MP:0009538 ! abnormal synapse morphology

[Term]
id: MP:0020362
name: abnormal male germ cell physiology
def: "any functional anomaly of male germ cells whether they are undifferentiated or fully differentiated" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003698 ! abnormal male reproductive system physiology
is_a: MP:0020363 ! abnormal germ cell physiology

[Term]
id: MP:0020363
name: abnormal germ cell physiology
def: "any functional anomaly of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8]
is_a: MP:0001919 ! abnormal reproductive system physiology
is_a: MP:0005621 ! abnormal cell physiology

[Term]
id: MP:0020364
name: abnormal female germ cell physiology
def: "any functional anomaly female germ cells whether they are undifferentiated or fully differentiated" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003699 ! abnormal female reproductive system physiology
is_a: MP:0020363 ! abnormal germ cell physiology

[Term]
id: MP:0020365
name: increased brain iron level
def: "increase in the amount of iron present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated brain iron level" EXACT []
is_a: MP:0008811 ! abnormal brain iron level
is_a: MP:0014541 ! increased iron level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020366
name: decreased brain iron level
def: "reduction in the amount of iron present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain iron level" EXACT []
is_a: MP:0008811 ! abnormal brain iron level
is_a: MP:0014542 ! decreased iron level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020367
name: increased heart iron level
def: "increase in the amount of iron present in the heart tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated cardiac iron level" EXACT []
synonym: "elevated heart iron level" EXACT []
synonym: "increased cardiac iron level" EXACT []
is_a: MP:0008741 ! abnormal heart iron level
is_a: MP:0014541 ! increased iron level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020368
name: decreased heart iron level
def: "reduction in the amount of iron present in the heart tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiac iron level" EXACT []
synonym: "reduced cardiac iron level" EXACT []
synonym: "reduced heart iron level" EXACT []
is_a: MP:0008741 ! abnormal heart iron level
is_a: MP:0014542 ! decreased iron level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020369
name: increased intestine iron level
def: "increase in the amount of iron present in the large or small intestinal tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated intestinal iron level" EXACT []
synonym: "increased intestinal iron level" EXACT []
is_a: MP:0008740 ! abnormal intestine iron level
is_a: MP:0014541 ! increased iron level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020370
name: abnormal glymphatic system morphology
def: "any structural anomaly in the macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system" [https://orcid.org/0000-0003-4606-0597, UBERON:0036145]
is_a: MP:0003632 ! abnormal nervous system morphology

[Term]
id: MP:0020371
name: abnormal glymphatic system physiology
def: "any functional anomaly in the macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system" [https://orcid.org/0000-0003-4606-0597, UBERON:0036145]
is_a: MP:0003633 ! abnormal nervous system physiology

[Term]
id: MP:0020372
name: abnormal tetrachloroethene metabolism
def: "altered ability to metabolize tetrachloroethene, a chlorinated olefin solvent with a variety of industrial applications, a ubiquitous contaminant of ground water, soil, ambient and urban air, and is one of the most common pollutants present in many hazardous waste sites" [CHEBI:17300, MPD:Molly]
synonym: "abnormal perchloroethylene metabolism" EXACT []
synonym: "abnormal tetrachloroethylene metabolism" EXACT []
is_a: MP:0013275 ! abnormal xenobiotic metabolism

[Term]
id: MP:0020373
name: abnormal blood vessel lumen formation
def: "any anomaly in the process in which a developing blood vessel forms an endothelial lumen through which blood will flow; in vertebrates, the lumen of all blood vessels is lined and formed by endothelial cells; in both vasculogenesis and angiogenesis, lumen formation takes place in a cord of endothelial cells and involves a complex mechanism composed of endothelial cell repulsion at the cell-cell contacts within the endothelial cell cords, junctional rearrangement, and endothelial cell shape change" [GO:0072554, https://orcid.org/0000-0002-6490-7723, PMID:22474612]
synonym: "abnormal blood vessel lumenization" EXACT []
is_a: MP:0000259 ! abnormal vascular development

[Term]
id: MP:0020374
name: abnormal nocifensive behavior
def: "any anomaly in a behavioral response to a noxious signal typically mediated by nociception" [https://orcid.org/0000-0003-4606-0597, ISBN:1588299333]
synonym: "abnormal nocifensive behaviour" EXACT []
is_a: MP:0004924 ! abnormal behavior

[Term]
id: MP:0020375
name: abnormal costotransverse joint morphology
def: "any anomaly in the structure of the articulation between the facet of the tubercle of a rib and the transverse process of a thoracic vertebra" [https://orcid.org/0000-0003-4606-0597, UBERON:0011967]
is_a: MP:0008149 ! abnormal costovertebral joint morphology

[Term]
id: MP:0020376
name: abnormal starburst amacrine cell morphology
def: "any structural anomaly of the retinal amacrine cells with a characteristic starburst shape of the dendritic arbor and that secrete both the the inhibitory neurotransmitter gamma-aminobutyric acid and the excitatory neurotransmitter acetylcholine" [http://webvision.med.utah.edu/book/part-iii-retinal-circuits/roles-of-amacrine-cells/, http://wiki.eyewire.org\:88/index.php?title=Starburst_Amacrine_Cell, PMID:24179230]
synonym: "abnormal SAC morphology" EXACT []
is_a: MP:0005240 ! abnormal amacrine cell morphology

[Term]
id: MP:0020377
name: abnormal dopaminergic amacrine cell morphology
def: "any structural anomaly of the retinal amacrine cells that express dopamine and are often identified by immunostaining for expression of tyrosine hydroxylase" [http://webvision.med.utah.edu/book/part-iii-retinal-circuits/roles-of-amacrine-cells/, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005240 ! abnormal amacrine cell morphology

[Term]
id: MP:0020378
name: abnormal cell cytoskeleton morphology
def: "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
is_a: MP:0014239 ! abnormal intracellular organelle morphology

[Term]
id: MP:0020379
name: abnormal sucrose solution preference
def: "any anomaly in the desire to drink water containing sucrose compared to consuming straight water" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001423 ! abnormal liquid preference

[Term]
id: MP:0020380
name: abnormal galactolipid level
def: "any anomaly in the concentrations of the glycolipids whose sugar group is galactose and that do not have nitrogen in their composition in the body" [CHEBI:5254, https://en.wikipedia.org/wiki/Galactolipid]
is_a: MP:0001547 ! abnormal lipid level

[Term]
id: MP:0020381
name: muscle gating pore current
def: "an anomalous non-selective cation current that is unaffected by the normal pore blockers and therefore represents ion movement through a permeation pathway in voltage-sensor domain of the protein rather than through the central pore" [PMID:16039561, PMID:25382261, PMID:25624448]
synonym: "omega current" EXACT []
is_a: MP:0004145 ! abnormal muscle electrophysiology

[Term]
id: MP:0020382
name: increased kidney epithelial cell primary cilium length
def: "increased length of the cilia on cells of the renal tubule or collecting duct" [https://orcid.org/0000-0001-5356-4174, PMID:19515853]
synonym: "elongated kidney epithelial cell primary cilium length" EXACT []
is_a: MP:0011065 ! abnormal kidney epithelial cell primary cilium morphology

[Term]
id: MP:0020383
name: decreased kidney epithelial cell primary cilium length
def: "decreased length of the cilia on cells of the renal tubule or collecting duct" [https://orcid.org/0000-0003-4606-0597]
synonym: "short kidney epithelial cell primary cilium" EXACT []
is_a: MP:0011065 ! abnormal kidney epithelial cell primary cilium morphology

[Term]
id: MP:0020384
name: absent kidney epithelial cell primary cilium
def: "absence of non-motile cilia on cells of the renal tubule or collecting duct" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011065 ! abnormal kidney epithelial cell primary cilium morphology

[Term]
id: MP:0020385
name: decreased intestine iron level
def: "reduction in the amount of iron present in the large or small intestinal tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased intestinal iron level" EXACT []
synonym: "reduced intestinal iron level" EXACT []
synonym: "reduced intestine iron level" EXACT []
is_a: MP:0008740 ! abnormal intestine iron level
is_a: MP:0014542 ! decreased iron level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020386
name: adipose tissue inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [https://orcid.org/0000-0002-6490-7723, PMID:24662293, PMID:24695736, PMID:26629401]
synonym: "adipose inflammation" EXACT []
synonym: "fat tissue inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0005666 ! abnormal adipose tissue physiology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020387
name: abnormal radial glial cell number
def: "anomaly in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003648 ! abnormal radial glial cell morphology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020388
name: decreased radial glial cell number
def: "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [https://orcid.org/0000-0002-6490-7723, PMID:25698753]
synonym: "reduced radial glial cell number" EXACT []
is_a: MP:0020387 ! abnormal radial glial cell number
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020389
name: increased radial glial cell number
def: "increase in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [https://orcid.org/0000-0002-6490-7723, PMID:25100583]
synonym: "elevated radial glial cell number" EXACT []
is_a: MP:0020387 ! abnormal radial glial cell number
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020390
name: abnormal radial glial cell endfoot morphology
def: "any structural anomaly of the tip of the elongated basal process that extends from the cell body of a radial glial cell through the entire cortical wall; the tip of the basal process, known as the basal endfoot, attaches to the pial basement membrane" [PMID:26382033]
synonym: "abnormal radial glial endfeet" EXACT []
synonym: "abnormal radial glial endfoot" EXACT []
is_a: MP:0003648 ! abnormal radial glial cell morphology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020391
name: radial glial endfoot detachment
def: "detachment of the radial glia cell endfoot from the pial basement membrane" [https://orcid.org/0000-0002-6490-7723, PMID:17715063, PMID:23217742, PMID:24256719]
synonym: "detached radial glia endfeet" EXACT []
is_a: MP:0020390 ! abnormal radial glial cell endfoot morphology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020392
name: abnormal radial glial cell apoptosis
def: "change in the timing or the number of radial glial cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723, PMID:25948253]
synonym: "abnormal radial glia apoptosis" EXACT []
is_a: MP:0010170 ! abnormal glial cell apoptosis
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020393
name: increased neuronal precursor proliferation
def: "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated neuroblast proliferation" EXACT []
synonym: "elevated neuronal precursor proliferation" EXACT []
synonym: "elevated neuronal progenitor proliferation" EXACT []
synonym: "increased neuroblast proliferation" EXACT []
synonym: "increased neuronal progenitor proliferation" EXACT []
is_a: MP:0004948 ! abnormal neuronal precursor proliferation
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020394
name: decreased neuronal precursor proliferation
def: "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased neuroblast proliferation" EXACT []
synonym: "decreased neuronal progenitor proliferation" EXACT []
synonym: "reduced neuroblast proliferation" EXACT []
synonym: "reduced neuronal precursor proliferation" EXACT []
synonym: "reduced neuronal progenitor proliferation" EXACT []
is_a: MP:0004948 ! abnormal neuronal precursor proliferation
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020395
name: abnormal response to social novelty
def: "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is for increased interaction with the novel individual" [PMID:23280234]
synonym: "abnormal response to novel conspecific" EXACT []
synonym: "abnormal social discrimination" EXACT []
is_a: MP:0001360 ! abnormal social investigation
is_a: MP:0003107 ! abnormal response to novelty
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020396
name: abnormal social recognition
def: "any anomaly in the ability of an individual to recognize another individual of the same species during repeated encounters" [PMID:11950245]
synonym: "abnormal social memory retention" EXACT []
is_a: MP:0001360 ! abnormal social investigation
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020397
name: abnormal megakaryocyte physiology
def: "any functional anomaly in the giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556]
synonym: "abnormal megacaryocyte physiology" EXACT []
synonym: "abnormal megalocaryocyte physiology" EXACT []
synonym: "abnormal megalokaryocyte physiology" EXACT []
is_a: MP:0009278 ! abnormal bone marrow cell physiology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020398
name: abnormal megakaryocyte emperipolesis
def: "any anomaly in the process by which a a megakaryocyte is penetrated by another living cell; unlike in phagocytosis the engulfed cell remains viable and may exit the megakaryocyte without damage to either cell" [PMID:25654060]
is_a: MP:0020397 ! abnormal megakaryocyte physiology
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020399
name: enhanced megakaryocyte emperipolesis
def: "an increase in the process by which a a megakaryocyte is penetrated by another living cell" [PMID:25654060, PMID:26950939]
is_a: MP:0020398 ! abnormal megakaryocyte emperipolesis
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020400
name: cystinuria
def: "excretion of excessive amounts of cystine in the urine" [HP:0003131]
synonym: "increased urine cystine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0021145 ! abnormal amino acid derivative level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020401
name: argininuria
def: "excretion of excessive amounts of arginine in the urine" [HP:0003268]
synonym: "increased urine arginine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030664 ! increased arginine level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020402
name: ornithinuria
def: "excretion of excessive amounts of ornithine in the urine" [HP:0003532]
synonym: "increased urine ornithine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030647 ! increased ornithine level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020403
name: lysinuria
def: "excretion of excessive amounts of lysine in the urine" [http://medical-dictionary.thefreedictionary.com/lysinuria]
synonym: "increased urine lysine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030721 ! increased lysine level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020404
name: prolinuria
def: "excretion of excessive amounts of proline in the urine" [HP:0003137]
synonym: "increased urine proline level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0020237 ! increased proline level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020405
name: taurinuria
def: "excretion of excessive amounts of taurine in the urine" [HP:0003166]
synonym: "increased urinary taurine level" EXACT []
synonym: "increased urine taurine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030635 ! increased taurine level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020406
name: hyperthreoninuria
def: "excretion of excessive amounts of threonine in the urine" [HP:0003296]
synonym: "increased urinary threonine" EXACT []
synonym: "increased urine threonine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030700 ! increased threonine level
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020407
name: abnormal placental thrombosis
def: "any anomaly in the formation or presence of one or more thrombi within the blood vessel network of the placenta" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005048 ! abnormal thrombosis
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020408
name: abnormal susceptibility to induced thrombosis
def: "any anomaly in the formation of thrombi following stimulation of thrombosis by an external agent" [PMID:16614756, PMID:9262402]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "altered susceptibility to induced thrombosis" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020409
name: abnormal cardiac thrombosis
def: "any anomaly in the formation or presence of one or more thrombi in the heart" [PMID:15870284]
synonym: "abnormal heart thrombosis" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020410
name: increased liposarcoma incidence
def: "greater than the expected number of malignant tumors derived from primitive or embryonal lipoblastic cells; these may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid, round-celled, or pleomorphic" [MESH:D008080, PMID:27573812]
is_a: MP:0002032 ! increased sarcoma incidence
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020411
name: increased abdominal adipose tissue amount
def: "increase in amount of adipose tissue associated with internal organs" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005452 ! abnormal adipose tissue amount
created_by: https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020412
name: abnormal amnion physiology
def: "any functional anomaly of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020413
name: increased amnion apoptosis
def: "increase in the number of cells of the amnion undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723, PMID:26494538]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0020412 ! abnormal amnion physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020414
name: abnormal fibroblast physiology
def: "any functional anomaly in the cellular physiological processes carried out by a fibroblast cell population" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005621 ! abnormal cell physiology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020415
name: abnormal fibroblast chemotaxis
def: "any anomaly in the directed movement of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal directed fibroblast migration" EXACT []
is_a: MP:0011518 ! abnormal cell chemotaxis
is_a: MP:0011706 ! abnormal fibroblast migration
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020416
name: decreased fibroblast chemotaxis
def: "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [https://orcid.org/0000-0002-6490-7723, PMID:20231695]
synonym: "impaired directed fibroblast migration" EXACT []
synonym: "impaired fibroblast chemotaxis" EXACT []
synonym: "reduced directed fibroblast migration" EXACT []
synonym: "reduced fibroblast chemotaxis" EXACT []
is_a: MP:0011708 ! decreased fibroblast cell migration
is_a: MP:0011825 ! decreased cell chemotaxis
is_a: MP:0020415 ! abnormal fibroblast chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020417
name: increased fibroblast chemotaxis
def: "increase in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [https://orcid.org/0000-0002-6490-7723, PMID:19217431]
synonym: "enhanced directed fibroblast migration" EXACT []
synonym: "enhanced fibroblast chemotaxis" EXACT []
synonym: "increased directed fibroblast migration" EXACT []
is_a: MP:0011709 ! increased fibroblast cell migration
is_a: MP:0011824 ! increased cell chemotaxis
is_a: MP:0020415 ! abnormal fibroblast chemotaxis
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020418
name: increased cardiac muscle relaxation
def: "greater than the normal ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [PMID:11565821, RGD:cur]
synonym: "enhanced cardiac muscle relaxation" EXACT []
synonym: "enhanced heart muscle relaxation" EXACT []
synonym: "increased heart muscle relaxation" EXACT []
is_a: MP:0004037 ! increased muscle relaxation
is_a: MP:0004084 ! abnormal cardiac muscle relaxation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020419
name: decreased cardiac muscle relaxation
def: "inability or reduced ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [PMID:11565821, RGD:cur]
synonym: "decreased heart muscle relaxation" EXACT []
synonym: "impaired cardiac muscle relaxation" EXACT []
synonym: "impaired heart muscle relaxation" EXACT []
is_a: MP:0003157 ! impaired muscle relaxation
is_a: MP:0004084 ! abnormal cardiac muscle relaxation
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: ORCID:orcid.org/0000-0003-4606-0597

[Term]
id: MP:0020420
name: abnormal freezing behavior
def: "any anomaly in the behavior defined as total cessation of movement apart from respiration or eye movement with the animal remaining alert with strong muscle tone; typically a response to potential danger" [PMID:11466423, PMID:12837573]
comment: In most prey animals this is part of a predator avoidance response, with the individual assuming a hunched posture {xref="PMID:12837573"}
synonym: "abnormal freezing behaviour" EXACT []
is_a: MP:0002065 ! abnormal fear/anxiety-related behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T15:58:02Z" xsd:dateTime

[Term]
id: MP:0020421
name: increased freezing behavior
def: "an elevated display, frequency, or duration of freezing behavior" []
synonym: "increased freezing behaviour" EXACT []
is_a: MP:0020420 ! abnormal freezing behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T16:00:48Z" xsd:dateTime

[Term]
id: MP:0020422
name: decreased freezing behavior
def: "a decreased display, frequency, or duration of freezing behavior" []
synonym: "decreased freezing behaviour" EXACT []
is_a: MP:0020420 ! abnormal freezing behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T16:01:02Z" xsd:dateTime

[Term]
id: MP:0020423
name: abnormal mitochondrial biogenesis
def: "Any anomaly in the the growth and division of pre-existing mitochondria." [PMID:20533901, PMID:25775561]
is_a: MP:0006036 ! abnormal mitochondrial physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T17:58:29Z" xsd:dateTime

[Term]
id: MP:0020424
name: increased kindling response
def: "increased epileptogenic changes, normally induced by daily sub threshold electrical brain stimulation" [PMID:27265781]
synonym: "enhanced kindling behavior" EXACT []
synonym: "enhanced kindling response" EXACT []
synonym: "increased kindling behavior" EXACT []
is_a: MP:0001499 ! abnormal kindling response
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T18:12:17Z" xsd:dateTime

[Term]
id: MP:0020425
name: abnormal retinal bipolar cell electrophysiology
def: "any functional anomaly of the retinal biopolar cells as determined through electrophysiological recordings from single cells or summary recordings from multiple cells" [PMID:12019334, PMID:15452577]
is_a: MP:0005551 ! abnormal eye electrophysiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-05-22T19:04:46Z" xsd:dateTime

[Term]
id: MP:0020426
name: abnormal beige fat cell physiology
def: "any functional anomaly of fat cells that are beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor" [CL_0001070, PMID:22796012, PMID:23603813, PMID:24575370]
synonym: "abnormal beige adipocyte physiology" EXACT []
synonym: "abnormal beige brown adipocyte physiology" EXACT []
synonym: "abnormal brite adipocyte physiology" EXACT []
synonym: "abnormal brite cell physiology" EXACT []
synonym: "abnormal brite fat cell physiology" EXACT []
is_a: MP:0005666 ! abnormal adipose tissue physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-05T18:35:23Z" xsd:dateTime

[Term]
id: MP:0020427
name: increased hepatocyte karyomegaly
def: "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http\://medical-dictionary.thefreedictionary.com/karyomegaly]
is_a: MP:0000607 ! abnormal hepatocyte morphology
is_a: MP:0003111 ! abnormal cell nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-05T18:49:48Z" xsd:dateTime

[Term]
id: MP:0020428
name: abnormal conditioned place aversion behavior
def: "anomaly in the ability of an animal to learn and remember an association between an unpleasant or punishing stimuli with a neutral, unchanging environment" [http://btc.psych.ucla.edu/cpp.htm, PMID:17487149]
synonym: "abnormal conditioned place aversion behaviour" EXACT []
is_a: MP:0001462 ! abnormal avoidance learning behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T15:47:27Z" xsd:dateTime

[Term]
id: MP:0020429
name: abnormal platelet alpha-granule number
def: "altered number of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
is_a: MP:0014060 ! abnormal platelet alpha-granule morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T17:13:09Z" xsd:dateTime

[Term]
id: MP:0020430
name: increased platelet alpha-granule number
def: "increased number of platelet alpha-granules" []
is_a: MP:0020429 ! abnormal platelet alpha-granule number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T17:13:32Z" xsd:dateTime

[Term]
id: MP:0020431
name: decreased platelet alpha-granule number
def: "decreased number of platelet alpha-granules" []
is_a: MP:0020429 ! abnormal platelet alpha-granule number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T17:13:51Z" xsd:dateTime

[Term]
id: MP:0020432
name: decreased platelet dense granule number
def: "decreased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
synonym: "decreased platelet delta granule number" EXACT []
synonym: "decreased platelet delta-granule number" EXACT []
synonym: "reduced platelet delta granule number" EXACT []
synonym: "reduced platelet delta-granule number" EXACT []
is_a: MP:0004722 ! abnormal platelet dense granule number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T17:25:18Z" xsd:dateTime

[Term]
id: MP:0020433
name: increased platelet dense granule number
def: "increased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
synonym: "increased platelet delta granule number" EXACT []
synonym: "increased platelet delta-granule number" EXACT []
is_a: MP:0004722 ! abnormal platelet dense granule number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-06-29T17:28:00Z" xsd:dateTime

[Term]
id: MP:0020434
name: increased astrocyte size
def: "increase in the size of the large neuroglial (macroglial) cells in the central nervous system" [CL:0000127, https://orcid.org/0000-0003-4606-0597]
synonym: "astrocyte hypertrophy" EXACT []
synonym: "enlarged astrocytes" EXACT []
synonym: "hypertrophic astrocytes" EXACT []
is_a: MP:0020436 ! abnormal astrocyte size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-07-26T19:04:10Z" xsd:dateTime

[Term]
id: MP:0020435
name: decreased astrocyte size
def: "decrease in the size of the large neuroglial (macroglial) cells in the central nervous system" [CL:0000127, https://orcid.org/0000-0003-4606-0597]
synonym: "astrocyte hypotrophy" EXACT []
synonym: "hypotrophic astrocytes" EXACT []
synonym: "reduced astrocyte size" EXACT []
synonym: "small astrocytes" EXACT []
is_a: MP:0020436 ! abnormal astrocyte size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-07-26T19:10:54Z" xsd:dateTime

[Term]
id: MP:0020436
name: abnormal astrocyte size
def: "anomaly in the size of the large neuroglial (macroglial) cells in the central nervous system" [CL:0000127, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0002182 ! abnormal astrocyte morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-07-26T19:26:35Z" xsd:dateTime

[Term]
id: MP:0020437
name: abnormal social play behavior
def: "behavior performed in the absence of normal stimuli or behavior elicited by normal stimuli but not followed to the completion of the ritualized behavior pattern that is associated with the socialization of an individual into the group" [https://orcid.org/0000-0003-4606-0597, NBO:0000049, NBO:0000075, RGD:gthayman]
synonym: "abnormal juvenile play behavior" RELATED []
synonym: "abnormal juvenile play behaviour" RELATED []
synonym: "abnormal social play behaviour" EXACT []
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-07-26T20:11:57Z" xsd:dateTime

[Term]
id: MP:0020438
name: decreased papilloma incidence
def: "fewer than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells occurring in a specific population in a given time period" [MPATH:445]
is_a: MP:0010283 ! decreased classified tumor incidence
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T15:53:35Z" xsd:dateTime

[Term]
id: MP:0020439
name: absent b-wave
def: "absence of the wave in the electroretinogram that reflects the health of the inner layers of the retina, including the ON bipolar cells and the Muller cells" [http://webvision.med.utah.edu/]
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T18:40:10Z" xsd:dateTime

[Term]
id: MP:0020440
name: abnormal front foot hair pigmentation
def: "an anomaly in the expected color gradient of hair covering the metacarpals and phalanges" [PMID:28043919]
synonym: "abnormal hand hair pigmentation" EXACT []
is_a: MP:0002075 ! abnormal coat/hair pigmentation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T19:15:05Z" xsd:dateTime

[Term]
id: MP:0020441
name: rhegmatogenous retina detachment
def: "a retinal detachment resulting from a break in the retina that allows vitreal fluid to pass into and accumulate in the subretinal space" [PMC:26978024]
synonym: "retinal tear" RELATED []
synonym: "rhegmatogenous retinal detachment" EXACT []
is_a: MP:0003099 ! retina detachment
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T19:43:13Z" xsd:dateTime

[Term]
id: MP:0020442
name: serous retina detachment
def: "a retinal detachment resulting from accumulation of fluid between the retina and retinal pigment epithelium in the absence of a retinal tear" [PMC:26978024]
synonym: "exudative retina detachment" EXACT []
synonym: "exudative retinal detachment" EXACT []
synonym: "serous retinal detachment" EXACT []
is_a: MP:0003099 ! retina detachment
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T19:46:42Z" xsd:dateTime

[Term]
id: MP:0020443
name: tractional retina detachment
def: "a retinal detachment caused by fibrous or fibrovascular tissue pulling the neuroretina away from the retinal pigment epithelium" [PMC:26978024]
synonym: "tractional retinal detachment" EXACT []
is_a: MP:0003099 ! retina detachment
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-16T19:50:05Z" xsd:dateTime

[Term]
id: MP:0020444
name: abnormal intestine apoptosis
def: "change in the timing or the number of intestinal cells undergoing programmed cell death" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal intestinal cell apoptosis" EXACT []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0010155 ! abnormal intestine physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-22T15:32:19Z" xsd:dateTime

[Term]
id: MP:0020445
name: abnormal NAD(P)H oxidase activity
def: "any anomaly in the ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174, RGD:sjwang]
synonym: "abnormal dual oxidase activity" EXACT []
synonym: "abnormal NAD(P)H:oxygen oxidoreductase activity" EXACT []
synonym: "abnormal NADPH oxidase activity" EXACT []
is_a: MP:0005584 ! abnormal enzyme/coenzyme activity
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T14:57:15Z" xsd:dateTime

[Term]
id: MP:0020446
name: increased NAD(P)H oxidase activity
def: "greater ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174]
synonym: "elevated NAD(P)H oxidase activity" EXACT []
synonym: "increased dual oxidase activity" EXACT []
synonym: "increased NAD(P)H:oxygen oxidoreductase activity" EXACT []
is_a: MP:0020445 ! abnormal NAD(P)H oxidase activity
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T17:12:36Z" xsd:dateTime

[Term]
id: MP:0020447
name: decreased NAD(P)H oxidase activity
def: "reduced ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174]
synonym: "decreased dual oxidase activity" EXACT []
synonym: "decreased NAD(P)H:oxygen oxidoreductase activity" EXACT []
synonym: "reduced NAD(P)H oxidase activity" EXACT []
is_a: MP:0020445 ! abnormal NAD(P)H oxidase activity
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T17:16:41Z" xsd:dateTime

[Term]
id: MP:0020448
name: increased microglial cell activation
def: "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
is_a: MP:0010762 ! abnormal microglial cell activation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T17:53:54Z" xsd:dateTime

[Term]
id: MP:0020449
name: decreased microglial cell activation
def: "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
is_a: MP:0010762 ! abnormal microglial cell activation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T17:54:12Z" xsd:dateTime

[Term]
id: MP:0020450
name: abnormal sperm progressive motility
def: "any anomaly in the ability of sperm to move in a more or less straight line" [http://www.equine-reproduction.com/articles/Sperm-Motility.shtml, https://orcid.org/0000-0003-4606-0597, https://www.verywell.com/sperm-motility-1960141]
is_a: MP:0002674 ! abnormal sperm motility
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T18:20:44Z" xsd:dateTime

[Term]
id: MP:0020451
name: decreased sperm progressive motility
def: "decrease in the ability of sperm to move in a more or less straight line" [https://orcid.org/0000-0003-4606-0597]
synonym: "impaired sperm progressive motility" EXACT []
synonym: "reduced sperm progressive motility" EXACT []
is_a: MP:0020450 ! abnormal sperm progressive motility
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T18:28:14Z" xsd:dateTime

[Term]
id: MP:0020452
name: abnormal axon radial sorting
def: "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [https://orcid.org/0000-0003-4606-0597, PMID:25686621]
is_a: MP:0003861 ! abnormal nervous system development
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T19:09:49Z" xsd:dateTime

[Term]
id: MP:0020453
name: abnormal erythrocyte aggregation
def: "any anomaly in the ability of an erythrocyte to adhere to one or more other erythrocytes via adhesion molecules" [GO:0034117, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal erythrocyte agglutinability" NARROW []
is_a: MP:0003656 ! abnormal erythrocyte physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T19:20:24Z" xsd:dateTime

[Term]
id: MP:0020454
name: decreased erythrocyte aggregation
def: "decrease in the ability of an erythrocyte to adhere to one or more other erythrocytes via adhesion molecules" [GO:0034117, https://orcid.org/0000-0003-4606-0597]
synonym: "low erythrocyte agglutinability" NARROW []
synonym: "reduced erythrocyte aggregation" EXACT []
is_a: MP:0020453 ! abnormal erythrocyte aggregation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T19:31:41Z" xsd:dateTime

[Term]
id: MP:0020455
name: increased erythrocyte aggregation
def: "increase in the ability of an erythrocyte to adhere to one or more other erythrocytes via adhesion molecules" [GO:0034117, https://orcid.org/0000-0003-4606-0597]
synonym: "elevated erythrocyte aggregation" EXACT []
synonym: "high erythrocyte agglutinability" NARROW []
is_a: MP:0020453 ! abnormal erythrocyte aggregation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-08-29T19:34:13Z" xsd:dateTime

[Term]
id: MP:0020456
name: decreased myelin sheath amount
def: "reduction in the amount of myelin surrounding nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
synonym: "hypomyelinated" EXACT []
synonym: "reduced myelin sheath amount" EXACT []
is_a: MP:0020457 ! abnormal myelin sheath amount
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T15:21:11Z" xsd:dateTime

[Term]
id: MP:0020457
name: abnormal myelin sheath amount
def: "any anomaly in the amount of myelin surrounding nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003871 ! abnormal myelin sheath morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T15:36:29Z" xsd:dateTime

[Term]
id: MP:0020458
name: increased myelin sheath amount
def: "increase in the amount of myelin surrounding nerve fibers or axons" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020457 ! abnormal myelin sheath amount
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T15:40:45Z" xsd:dateTime

[Term]
id: MP:0020459
name: abnormal gum morphology
def: "any structural anomaly of the fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth" [UBERON:0001828]
synonym: "abnormal gingiva morphology" EXACT []
is_a: MP:0003745 ! abnormal oral mucosa morphology
is_a: MP:0030131 ! abnormal periodontium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T18:13:52Z" xsd:dateTime

[Term]
id: MP:0020460
name: abnormal gum epithelium morphology
def: "any structural anomaly in the stratified squamous epithelium of the gums" [UBERON:0001949]
synonym: "abnormal gingival epithelium morphology" EXACT []
is_a: MP:0020459 ! abnormal gum morphology
is_a: MP:0030179 ! abnormal oral epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T18:18:39Z" xsd:dateTime

[Term]
id: MP:0020461
name: superior semicircular canal dehiscence
def: "absence of part of the temporal bone overlying the superior semicircular canal facing toward the dura of the middle cranial fossa creating a third mobile window" [http://0000-0003-3311-7320, ORCID:0000-0002-2244-7917, PMID:10680863]
is_a: MP:0003069 ! abnormal superior semicircular canal morphology
is_a: MP:0005272 ! abnormal temporal bone morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-11T20:18:45Z" xsd:dateTime

[Term]
id: MP:0020462
name: abnormal megakaryocyte progenitor cell number
def: "any anomaly in the number of the progenitor cells of the thrombocytic (platelet) line of cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal CFU-Mk number" EXACT []
synonym: "abnormal colony forming unit megakaryocyte number" EXACT []
synonym: "abnormal megacaryoblast number" EXACT []
synonym: "abnormal megacaryocyte progenitor cell number" EXACT []
synonym: "abnormal megakaryoblast number" EXACT []
synonym: "abnormal promegacaryocyte number" EXACT []
synonym: "abnormal promegakaryocyte number" EXACT []
is_a: MP:0002413 ! abnormal megakaryocyte progenitor cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-25T15:10:50Z" xsd:dateTime

[Term]
id: MP:0020463
name: increased megakaryocyte progenitor cell number
def: "increase in the number of the progenitor cells of the thrombocytic (platelet) line of cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated colony forming unit megakaryocyte number" EXACT []
synonym: "elevated megacaryoblast number" EXACT []
synonym: "elevated megakaryocyte progenitor cell number" EXACT []
synonym: "elevated promegacaryocyte number" EXACT []
synonym: "increased CFU-Mk number" EXACT []
synonym: "increased megacaryocyte progenitor cell number" EXACT []
synonym: "increased megakaryoblast number" EXACT []
synonym: "increased promegakaryocyte number" EXACT []
is_a: MP:0020462 ! abnormal megakaryocyte progenitor cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-25T15:11:04Z" xsd:dateTime

[Term]
id: MP:0020464
name: decreased megakaryocyte progenitor cell number
def: "decrease in the number of the progenitor cells of the thrombocytic (platelet) line of cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased CFU-Mk number" EXACT []
synonym: "decreased colony forming unit megakaryocyte number" EXACT []
synonym: "decreased megacaryoblast number" EXACT []
synonym: "decreased megakaryoblast number" EXACT []
synonym: "decreased promegacaryocyte number" EXACT []
synonym: "reduced megacaryocyte progenitor cell number" EXACT []
synonym: "reduced megakaryocyte progenitor cell number" EXACT []
synonym: "reduced promegakaryocyte number" EXACT []
is_a: MP:0020462 ! abnormal megakaryocyte progenitor cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-25T15:11:13Z" xsd:dateTime

[Term]
id: MP:0020465
name: abnormal megakaryocyte progenitor cell physiology
def: "any functional anomaly in the earliest cytologically identifiable precursor in the thrombocytic series" [CL:0000553]
synonym: "abnormal CFU-Mk physiology" EXACT []
synonym: "abnormal colony forming unit megakaryocyte physiology" EXACT []
synonym: "abnormal megacaryoblast physiology" EXACT []
synonym: "abnormal megacaryocyte progenitor cell physiology" EXACT []
synonym: "abnormal promegacaryocyte physiology" EXACT []
synonym: "abnormal promegakaryocyte physiology" EXACT []
is_a: MP:0009278 ! abnormal bone marrow cell physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-25T15:28:32Z" xsd:dateTime

[Term]
id: MP:0020466
name: increased megakaryocyte progenitor cell proliferation
def: "anomaly in the ability of the progenitor cells of the thrombocytic (platelet) line of cells to undergo expansion by cell division" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased CFU-Mk proliferation" EXACT []
synonym: "increased colony forming unit megakaryocyte proliferation" EXACT []
synonym: "increased megacaryoblast proliferation" EXACT []
synonym: "increased megacaryocyte progenitor cell proliferation" EXACT []
synonym: "increased megakaryoblast proliferation" EXACT []
synonym: "increased promegacaryocyte proliferation" EXACT []
synonym: "increased promegakaryocyte proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0020465 ! abnormal megakaryocyte progenitor cell physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-25T15:30:48Z" xsd:dateTime

[Term]
id: MP:0020467
name: abnormal circadian behavior
def: "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
synonym: "abnormal circadian behaviour" EXACT []
synonym: "abnormal circadian rhythm behavior" EXACT []
synonym: "abnormal circadian rhythm behaviour" EXACT []
is_a: MP:0021121 ! abnormal rhythmic behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:17:08Z" xsd:dateTime

[Term]
id: MP:0020468
name: abnormal circadian behavior period
def: "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal circadian behaviour period" EXACT []
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:25:37Z" xsd:dateTime

[Term]
id: MP:0020469
name: prolonged circadian behavior period
def: "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [https://orcid.org/0000-0003-4606-0597]
synonym: "prolonged circadian behaviour period" EXACT []
is_a: MP:0020468 ! abnormal circadian behavior period
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:26:01Z" xsd:dateTime

[Term]
id: MP:0020470
name: shortened circadian behavior period
def: "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [https://orcid.org/0000-0003-4606-0597]
synonym: "shortened circadian behaviour period" EXACT []
is_a: MP:0020468 ! abnormal circadian behavior period
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:26:25Z" xsd:dateTime

[Term]
id: MP:0020471
name: abnormal circadian behavior persistence
def: "anomaly in the ability for an animal to retain a circadian behavior when time cues are removed" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal circadian behaviour persistence" EXACT []
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:34:59Z" xsd:dateTime

[Term]
id: MP:0020472
name: arrhythmic circadian behavior persistence
def: "loss of a behavioral rhythmic pattern upon removal of time cues" [https://orcid.org/0000-0003-4606-0597]
synonym: "arrhythmic circadian behaviour persistence" EXACT []
is_a: MP:0020471 ! abnormal circadian behavior persistence
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:35:30Z" xsd:dateTime

[Term]
id: MP:0020473
name: abnormal circadian behavior phase
def: "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal circadian behaviour phase" EXACT []
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:40:46Z" xsd:dateTime

[Term]
id: MP:0020474
name: advanced circadian behavior phase
def: "increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [https://orcid.org/0000-0003-4606-0597]
synonym: "advanced circadian behaviour phase" EXACT []
synonym: "decreased circadian behavior phase delay" EXACT []
synonym: "decreased circadian behaviour phase delay" EXACT []
is_a: MP:0020473 ! abnormal circadian behavior phase
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:41:03Z" xsd:dateTime

[Term]
id: MP:0020475
name: delayed circadian behavior phase
def: "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed circadian behaviour phase" EXACT []
synonym: "increased circadian behavior phase delay" EXACT []
synonym: "increased circadian behaviour phase delay" EXACT []
is_a: MP:0020473 ! abnormal circadian behavior phase
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:41:19Z" xsd:dateTime

[Term]
id: MP:0020476
name: abnormal circardian behavior entrainment
def: "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
synonym: "abnormal circardian behaviour entrainment" EXACT []
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:48:12Z" xsd:dateTime

[Term]
id: MP:0020477
name: abnormal locomotor circadian rhythm
def: "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
synonym: "abnormal circadian locomotor activity rhythm" EXACT []
synonym: "abnormal locomotor rhythm" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T18:57:25Z" xsd:dateTime

[Term]
id: MP:0020478
name: abnormal circadian sleep/wake cycle
def: "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
is_a: MP:0001501 ! abnormal sleep pattern
is_a: MP:0020467 ! abnormal circadian behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T19:02:23Z" xsd:dateTime

[Term]
id: MP:0020479
name: abnormal circadian hormone homeostasis
def: "any anomaly in the process in which an organism modulates its hormone levels at different values with a regularity of approximately 24 hours" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T19:27:44Z" xsd:dateTime

[Term]
id: MP:0020480
name: abnormal ultradian rhythm behavior
def: "any anomaly in the specific behavioral actions or reactions of an organism that recur with a regularity more frequent than every 24 hours" [GO:0007624]
synonym: "abnormal ultradian rhythm behaviour" EXACT []
is_a: MP:0021121 ! abnormal rhythmic behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-09-27T19:35:17Z" xsd:dateTime

[Term]
id: MP:0020481
name: abnormal basilar artery development
def: "aberrant formation or patterning or incomplete differentiation of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MP:0013186]
is_a: MP:0003410 ! abnormal artery development
is_a: MP:0013186 ! abnormal basilar artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T15:14:19Z" xsd:dateTime

[Term]
id: MP:0020482
name: abnormal brain vascular topology
def: "abnormal position of the blood vessels of the brain in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004950 ! abnormal brain vasculature morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T15:32:16Z" xsd:dateTime

[Term]
id: MP:0020483
name: abnormal brain artery topology
def: "abnormal position of the arteries of the brain in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020482 ! abnormal brain vascular topology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T15:32:30Z" xsd:dateTime

[Term]
id: MP:0020484
name: abnormal brain internal capsule topology
def: "abnormal position of the brain internal capsule" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal internal capsule of telencephalon topology" EXACT []
is_a: MP:0008128 ! abnormal brain internal capsule morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T15:45:55Z" xsd:dateTime

[Term]
id: MP:0020485
name: abnormal inferior vena cava topology
def: "abnormal position of the inferior vena cava" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal inferior caval vein topology" EXACT []
synonym: "abnormal IVC topology" EXACT []
is_a: MP:0006063 ! abnormal inferior vena cava morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T15:54:27Z" xsd:dateTime

[Term]
id: MP:0020486
name: abnormal lens topology
def: "abnormal position or orientation of the lens in relation to other structures of the eye" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal lens position" EXACT []
is_a: MP:0001303 ! abnormal lens morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T19:09:33Z" xsd:dateTime

[Term]
id: MP:0020487
name: abnormal middle cerebral artery morphology
def: "any structural anomaly of the major paired arteries that arise from the internal carotid artery and supply blood to a portion of the frontal lobe and the lateral surface of the temporal and parietal lobes" [http://www.strokecenter.org/professionals/brain-anatomy/blood-vessels-of-the-brain/, https://radiopaedia.org/articles/middle-cerebral-artery]
synonym: "abnormal MCA morphology" EXACT []
is_a: MP:0013821 ! abnormal cerebral artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T19:19:25Z" xsd:dateTime

[Term]
id: MP:0020488
name: abnormal middle cerebral artery origin
def: "any anomaly in the position from which the middle cerebral artery arises" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal MCA origin" EXACT []
is_a: MP:0020487 ! abnormal middle cerebral artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T19:36:06Z" xsd:dateTime

[Term]
id: MP:0020489
name: abnormal ophthalmic artery morphology
def: "any structural anomaly in the artery that arises from the internal carotic artery medial to the anterior clinoid process which branches to supply the eye and other structures in the orbit with blood" [https://radiopaedia.org/articles/ophthalmic-artery, UBERON:0001619]
is_a: MP:0002191 ! abnormal artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T19:51:28Z" xsd:dateTime

[Term]
id: MP:0020490
name: abnormal ophthalmic artery origin
def: "any anomaly in the position from which the opthalmic artery arises" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020489 ! abnormal ophthalmic artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T19:51:58Z" xsd:dateTime

[Term]
id: MP:0020491
name: abnormal ovary topology
def: "any anomaly in the position of the ovary in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001126 ! abnormal ovary morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T20:06:28Z" xsd:dateTime

[Term]
id: MP:0020492
name: abnormal superior mesenteric vein topology
def: "any anomaly in the position of the superior mesenteric vein in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013983 ! abnormal superior mesenteric vein morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-11T20:15:15Z" xsd:dateTime

[Term]
id: MP:0020493
name: absent inferior vena cava
def: "absence of the entire length of the principal vein draining blood from the lower portion of the body" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent IVC" EXACT []
is_a: MP:0006063 ! abnormal inferior vena cava morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T14:44:38Z" xsd:dateTime

[Term]
id: MP:0020494
name: left sided inferior vena cava
def: "the infrarenal segment of the inferior vena cava is present on the left side of the body instead of on the right side; typically as a result of regression of the right supracardinal vein and persistence of the left supracardinal vein" [http://www.sciencedirect.com/science/article/pii/S1533316707000374, https://radiopaedia.org/articles/transposition-of-inferior-vena-cava, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921701/]
is_a: MP:0020485 ! abnormal inferior vena cava topology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T14:54:07Z" xsd:dateTime

[Term]
id: MP:0020495
name: abnormal embryonic lymph sac morphology
def: "any structural anomaly of the population of lymphatic endothelial cell precursors that will form the lymph vessels" [UBERON:0034953]
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T15:08:00Z" xsd:dateTime

[Term]
id: MP:0020496
name: absent motoric part of trigeminal nerve
def: "absence of the part of the trigeminal nerve containing motor fibers, this derives from the basal plate of the embryonic pons and goes into the mandibular branch of the trigeminal nerve" [http://teachmeanatomy.info/head/cranial-nerves/trigeminal-nerve/, https://en.wikipedia.org/wiki/Trigeminal_nerve]
is_a: MP:0001066 ! absent trigeminal nerve
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T15:35:58Z" xsd:dateTime

[Term]
id: MP:0020497
name: absent splanchnic nerve
def: "absence of the splanchnic nerve" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008318 ! abnormal splanchnic nerve morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T15:47:35Z" xsd:dateTime

[Term]
id: MP:0020498
name: heterochrony of entire embryo
def: "a change in the timing or rate of events that alters the size or shape of the entire embryo" [https://en.wikipedia.org/wiki/Heterochrony, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014021 ! heterochrony
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T15:56:20Z" xsd:dateTime

[Term]
id: MP:0020499
name: persistent right umbilical vein
def: "failure of the right umbilical vein to regress" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010667 ! abnormal umbilical vein morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T16:00:10Z" xsd:dateTime

[Term]
id: MP:0020500
name: persistent trigeminal artery
def: "failure of the trigeminal artery, the artery that  supplies the basilar artery with blood during development, to regress" [https://en.wikipedia.org/wiki/Trigeminal_artery, https://radiopaedia.org/articles/persistent-primitive-trigeminal-artery]
synonym: "persistent primitive trigeminal artery" EXACT []
synonym: "PPTA" EXACT []
is_a: MP:0003410 ! abnormal artery development
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T16:54:55Z" xsd:dateTime

[Term]
id: MP:0020501
name: thin mandibular nerve
def: "a slender apperance of the mandibular nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "thin CN V3" EXACT []
synonym: "thin V3 nerve" EXACT []
is_a: MP:0009800 ! abnormal mandibular nerve morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T17:01:07Z" xsd:dateTime

[Term]
id: MP:0020502
name: abnormal physiological umbilical hernia morphology
def: "any structural anomaly in the developmental umbilical hernia that occurs when the elongating intestine herniates into the base of the umbilical cord, this normally resolves when the size of the abdomen increases" [http://www.fetalultrasound.com/online/text/3-097.HTM, https://radiopaedia.org/articles/physiological-gut-herniation]
is_a: MP:0001725 ! abnormal umbilical cord morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T17:50:13Z" xsd:dateTime

[Term]
id: MP:0020503
name: abnormal sympathetic trunk morphology
def: "any structural anomaly of the two long ganglionated nerve strands that run lateral to the vertebral column and extend from the base of the skull to the coccyx;" [http://medical-dictionary.thefreedictionary.com/sympathetic+trunk, http://www.sciencedirect.com/topics/neuroscience/sympathetic-trunk]
synonym: "abnormal sympathetic chain morphology" EXACT []
synonym: "abnormal sympathetic nerve trunk morphology" EXACT []
is_a: MP:0001007 ! abnormal sympathetic system morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T18:00:26Z" xsd:dateTime

[Term]
id: MP:0020504
name: abnormal cervical sympathetic trunk morphology
def: "any structural anomaly of the portion of the sympathetic trunk located in front of the front of the transverse processes of cervical vertebrae and neck of the 1st rib behind the carotid sheaths and in front of prevertebral fascia" [https://www.earthslab.com/anatomy/cervical-part-of-the-sympathetic-trunk/#gsc.tab=0]
synonym: "abnormal cervical sympathetic nerve trunk morphology" EXACT []
is_a: MP:0020503 ! abnormal sympathetic trunk morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T18:05:57Z" xsd:dateTime

[Term]
id: MP:0020505
name: absent cervical sympathetic trunk
def: "absence of the cervical section of the sympathetic trunk" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent cervical sympathetic nerve trunk" EXACT []
is_a: MP:0020504 ! abnormal cervical sympathetic trunk morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-10-12T18:11:37Z" xsd:dateTime

[Term]
id: MP:0020506
name: abnormal dendritic spine density
def: "any anomaly in the number of dendritic spines in a given cross-sectional area of a dendrite" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:31:22Z" xsd:dateTime

[Term]
id: MP:0020507
name: increased dendritic spine density
def: "increase in the number of dendritic spines in a given cross-sectional area of a dendrite" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020506 ! abnormal dendritic spine density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:36:40Z" xsd:dateTime

[Term]
id: MP:0020508
name: decreased dendritic spine density
def: "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020506 ! abnormal dendritic spine density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:36:59Z" xsd:dateTime

[Term]
id: MP:0020509
name: abnormal dendritic spine length
def: "any anomaly in the distance from the base to head of a dendritic spine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:40:51Z" xsd:dateTime

[Term]
id: MP:0020510
name: increased dendritic spine length
def: "increase in the distance from the base to head of a dendritic spine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020509 ! abnormal dendritic spine length
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:49:53Z" xsd:dateTime

[Term]
id: MP:0020511
name: decreased dendritic spine length
def: "decrease in the distance from the base to head of a dendritic spine" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020509 ! abnormal dendritic spine length
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T16:50:12Z" xsd:dateTime

[Term]
id: MP:0020512
name: abnormal dendritic mushroom spine morphology
def: "any structural anomaly of the dendritic spines that have a thin neck and large bulbous head" [PMID:22791026]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T18:31:40Z" xsd:dateTime

[Term]
id: MP:0020513
name: abnormal dendritic stubby spine morphology
def: "any structural anomaly of the dendritic spines that have a bulbous head but lack a thin neck; these are typically prominent in postnatal development" [PMID:22791026]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T18:33:02Z" xsd:dateTime

[Term]
id: MP:0020514
name: abnormal dendritic thin spine morphology
def: "any structural anomaly of the dendritic spines that have a long, thin neck and a small bulbous head" [PMID:22791026]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2017-11-06T18:33:47Z" xsd:dateTime

[Term]
id: MP:0020515
name: abnormal visceral yolk sac endoderm morphology
def: "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T15:55:15Z" xsd:dateTime

[Term]
id: MP:0020516
name: abnormal visceral yolk sac mesenchyme morphology
def: "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
is_a: MP:0001718 ! abnormal visceral yolk sac morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T16:15:49Z" xsd:dateTime

[Term]
id: MP:0020517
name: abnormal visceral yolk sac physiology
def: "any functional anomaly of the  extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" [MP:0001718]
is_a: MP:0004264 ! abnormal extraembryonic tissue physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T16:24:20Z" xsd:dateTime

[Term]
id: MP:0020518
name: renal glomerular protein deposits
def: "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T19:12:26Z" xsd:dateTime

[Term]
id: MP:0020519
name: renal glomerular immunoglobulin deposits
def: "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
is_a: MP:0020518 ! renal glomerular protein deposits
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T19:16:15Z" xsd:dateTime

[Term]
id: MP:0020520
name: whitened brown adipose tissue morphology
def: "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
synonym: "brown fat whitening" EXACT []
is_a: MP:0002971 ! abnormal brown adipose tissue morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T19:50:53Z" xsd:dateTime

[Term]
id: MP:0020521
name: browned white adipose tissue morphology
def: "white adipose tissue displays a morphology more closely resembling brown adipose tissue (eg. multilocular droplets, decreased lipid droplet size) including the emergence or brown or beige adipocytes in white adipose tissue; this may represent adaptation to increased thermogenic demand, exercise, injury (thermal injury), and/or disease (cancer)" [MGI:mperry, PMID:24531262, PMID:27397607]
synonym: "beiging of WAT" EXACT []
synonym: "beiging of white adipose tissue" EXACT []
synonym: "browning of WAT" EXACT []
synonym: "browning of white adipose tissue" EXACT []
synonym: "WAT beiging" EXACT []
synonym: "WAT browning" EXACT []
synonym: "white adipose tissue browning" EXACT []
is_a: MP:0002970 ! abnormal white adipose tissue morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T19:55:27Z" xsd:dateTime

[Term]
id: MP:0020522
name: decreased susceptibility to xenobiotic induced hyperthermia
def: "reduction in the expected increase  in body temperature following xenobiotic treatment to induced hyperthermia (eg. isopropanol)" [MGI:mperry, PMID:24531262]
synonym: "resistance to xenobiotic induced hyperthermia" EXACT []
is_a: MP:0008874 ! decreased physiological sensitivity to xenobiotic
is_a: MP:0011019 ! abnormal adaptive thermogenesis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T20:42:24Z" xsd:dateTime

[Term]
id: MP:0020523
name: decreased susceptibility to induced hypothermia
def: "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
synonym: "resistance to induced hypothermia" EXACT []
is_a: MP:0011019 ! abnormal adaptive thermogenesis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-10T20:52:35Z" xsd:dateTime

[Term]
id: MP:0020524
name: abnormal behavioral response to methylenedioxymethamphetamine
def: "anomaly in the behavioral response induced by methylenedioxymethamphetamine such as induced hyperactivity or stereotypic behavior" [CHEBI:1391, MPD:Molly]
synonym: "abnormal behavioral response to 3,4-methylenedioxymethamphetamine" EXACT []
synonym: "abnormal behavioral response to ecstacy" EXACT []
synonym: "abnormal behavioral response to MDMA" EXACT []
synonym: "abnormal behavioural response to 3,4-methylenedioxymethamphetamine" EXACT []
synonym: "abnormal behavioural response to ecstacy" EXACT []
synonym: "abnormal behavioural response to MDMA" EXACT []
synonym: "abnormal behavioural response to methylenedioxymethamphetamine" EXACT []
is_a: MP:0013894 ! abnormal behavioral response to amphetamine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T16:58:21Z" xsd:dateTime

[Term]
id: MP:0020525
name: abnormal thalamus size
def: "anomaly in the average size of the large ovoid mass of paired bodies containing mostly grey matter and forming part of the lateral wall of the third ventricle of the brain" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:20:37Z" xsd:dateTime

[Term]
id: MP:0020526
name: enlarged thalamus
def: "increased size of the thalamus" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased thalamus size" EXACT []
is_a: MP:0020525 ! abnormal thalamus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:23:32Z" xsd:dateTime

[Term]
id: MP:0020527
name: small thalamus
def: "decreased size of the thalamus" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased thalamus size" EXACT []
synonym: "reduced thalamus size" EXACT []
is_a: MP:0020525 ! abnormal thalamus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:26:52Z" xsd:dateTime

[Term]
id: MP:0020528
name: thalamus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the thalamus, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "hypoplastic thalamus" EXACT []
is_a: MP:0020527 ! small thalamus
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:30:43Z" xsd:dateTime

[Term]
id: MP:0020529
name: ectopic thalamus
def: "abnormal position of the thalamus" [] {def="https://orcid.org/0000-0003-4606-0597"}
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:35:35Z" xsd:dateTime

[Term]
id: MP:0020530
name: disorganized thalamus
def: "derangement of the pattern of thalamic tissues" [https://orcid.org/0000-0003-4606-0597]
synonym: "disorganised thalamus" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-01-24T20:40:28Z" xsd:dateTime

[Term]
id: MP:0020531
name: increased cerebellar foliation
def: "the cerebellar lobules are increased in size or number" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased cerebellum foliation" EXACT []
synonym: "increased folia" EXACT []
is_a: MP:0000857 ! abnormal cerebellar foliation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:05:08Z" xsd:dateTime

[Term]
id: MP:0020532
name: abnormal pons size
def: "a deviation from the normal size of the pons" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000848 ! abnormal pons morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:14:06Z" xsd:dateTime

[Term]
id: MP:0020533
name: decreased pons size
def: "decreased size of or number of the nerve fibers in the pons" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced pons size" EXACT []
synonym: "small pons" EXACT []
is_a: MP:0020532 ! abnormal pons size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:19:18Z" xsd:dateTime

[Term]
id: MP:0020534
name: increased pons size
def: "increased size of or number of the nerve fibers in the pons" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged pons" EXACT []
is_a: MP:0020532 ! abnormal pons size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:19:29Z" xsd:dateTime

[Term]
id: MP:0020535
name: abnormal subiculum size
def: "a deviation from the normal size of the subiculum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0008287 ! abnormal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:29:50Z" xsd:dateTime

[Term]
id: MP:0020536
name: increased subiculum size
def: "increase in the size of the subiculum" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged subiculum" EXACT []
is_a: MP:0020535 ! abnormal subiculum size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:32:21Z" xsd:dateTime

[Term]
id: MP:0020537
name: decreased subiculum size
def: "decreased size of the subiculum" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced subiculum size" EXACT []
synonym: "small subiculum" EXACT []
is_a: MP:0020535 ! abnormal subiculum size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:32:48Z" xsd:dateTime

[Term]
id: MP:0020538
name: abnormal cerebellum fastigial nucleus size
def: "a deviation from the normal size of the cerebellum fastigial nucleus" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal cerebellum roof nucleus size" EXACT []
synonym: "abnormal cerebellum tectal nucleus size" EXACT []
synonym: "abnormal medial cerebellar nucleus size" EXACT []
is_a: MP:0009983 ! abnormal cerebellum fastigial nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:49:51Z" xsd:dateTime

[Term]
id: MP:0020539
name: increased cerebellum fastigial nucleus size
def: "increased size of the cerebellum fastigial nucleus" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged cerebellum roof nucleus" EXACT []
synonym: "enlarged cerebellum tectal nucleus" EXACT []
synonym: "enlarged medial cerebellar nucleus" EXACT []
synonym: "increased cerebellum roof nucleus size" EXACT []
synonym: "increased cerebellum tectal nucleus size" EXACT []
synonym: "increased medial cerebellar nucleus size" EXACT []
is_a: MP:0020538 ! abnormal cerebellum fastigial nucleus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:53:20Z" xsd:dateTime

[Term]
id: MP:0020540
name: decreased cerebellum fastigial nucleus size
def: "decreased size of the cerebellum fastigial nucleus" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cerebellum roof nucleus size" EXACT []
synonym: "decreased cerebellum tectal nucleus size" EXACT []
synonym: "decreased medial cerebellar nucleus size" EXACT []
synonym: "reduced cerebellum fastigial nucleus size" EXACT []
synonym: "reduced cerebellum roof nucleus size" EXACT []
synonym: "reduced cerebellum tectal nucleus size" EXACT []
synonym: "reduced medial cerebellar nucleus size" EXACT []
synonym: "small cerebellum fastigial nucleus" EXACT []
synonym: "small cerebellum roof nucleus" EXACT []
synonym: "small cerebellum tectal nucleus" EXACT []
synonym: "small medial cerebellar nucleus" EXACT []
is_a: MP:0020538 ! abnormal cerebellum fastigial nucleus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T16:53:49Z" xsd:dateTime

[Term]
id: MP:0020541
name: abnormal substantia nigra size
def: "a deviation from the normal size of the substantia nigra" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal locus niger size" EXACT []
synonym: "abnormal nucleus niger size" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T17:04:08Z" xsd:dateTime

[Term]
id: MP:0020542
name: increased substantia nigra size
def: "increased size of the substantia nigra" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged locus niger" EXACT []
synonym: "enlarged nucleus niger" EXACT []
synonym: "enlarged substantia nigra" EXACT []
synonym: "increased locus niger size" EXACT []
synonym: "increased nucleus niger size" EXACT []
is_a: MP:0020541 ! abnormal substantia nigra size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T17:04:20Z" xsd:dateTime

[Term]
id: MP:0020543
name: decreased substantia nigra size
def: "decreased size of the substantia nigra" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased locus niger size" EXACT []
synonym: "decreased nucleus niger size" EXACT []
synonym: "reduced locus niger size" EXACT []
synonym: "reduced nucleus niger size" EXACT []
synonym: "reduced substantia nigra size" EXACT []
synonym: "small locus niger" EXACT []
synonym: "small nucleus niger" EXACT []
synonym: "small substantia nigra" EXACT []
is_a: MP:0020541 ! abnormal substantia nigra size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T17:04:30Z" xsd:dateTime

[Term]
id: MP:0020544
name: abnormal hippocampal fornix size
def: "a deviation from the normal size of the hippocampal fornix" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fornix hippocampus size" EXACT []
synonym: "abnormal hippocampus fornix size" EXACT []
is_a: MP:0003006 ! abnormal hippocampal fornix morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:12:03Z" xsd:dateTime

[Term]
id: MP:0020545
name: decreased hippocampal fornix size
def: "decreased size of the hippocampal fornix" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased fornix hippocampus size" EXACT []
synonym: "decreased hippocampus fornix size" EXACT []
synonym: "reduced fornix hippocampus size" EXACT []
synonym: "reduced hippocampal fornix size" EXACT []
synonym: "reduced hippocampus fornix size" EXACT []
synonym: "small fornix hippocampus" EXACT []
synonym: "small hippocampal fornix" EXACT []
synonym: "small hippocampus fornix" EXACT []
is_a: MP:0020544 ! abnormal hippocampal fornix size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:12:23Z" xsd:dateTime

[Term]
id: MP:0020546
name: increased hippocampal fornix size
def: "increased size of the hippocampal fornix" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged fornix hippocampus" EXACT []
synonym: "enlarged hippocampal fornix" EXACT []
synonym: "enlarged hippocampus fornix" EXACT []
synonym: "increased fornix hippocampus size" EXACT []
synonym: "increased hippocampus fornix size" EXACT []
is_a: MP:0020544 ! abnormal hippocampal fornix size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:12:35Z" xsd:dateTime

[Term]
id: MP:0020547
name: abnormal optic chiasm size
def: "a deviation from the normal size of the optic chiasm" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal optic chiasma size" EXACT []
synonym: "abnormal optic decussation size" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:24:36Z" xsd:dateTime

[Term]
id: MP:0020548
name: decreased optic chiasm size
def: "decreased size of the optic chiasm" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased optic chiasma size" EXACT []
synonym: "decreased optic decussation size" EXACT []
synonym: "reduced optic chiasm size" EXACT []
synonym: "reduced optic chiasma size" EXACT []
synonym: "reduced optic decussation size" EXACT []
synonym: "small optic chiasm" EXACT []
synonym: "small optic chiasma" EXACT []
synonym: "small optic decussation" EXACT []
is_a: MP:0020547 ! abnormal optic chiasm size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:25:15Z" xsd:dateTime

[Term]
id: MP:0020549
name: increased optic chiasm size
def: "increased size of the optic chiasm" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged optic chiasm" EXACT []
synonym: "enlarged optic chiasma" EXACT []
synonym: "enlarged optic decussation" EXACT []
synonym: "increased optic chiasma size" EXACT []
synonym: "increased optic decussation size" EXACT []
is_a: MP:0020547 ! abnormal optic chiasm size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T18:25:25Z" xsd:dateTime

[Term]
id: MP:0020550
name: multinucleated giant male germ cells
def: "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https\://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
synonym: "multinucleated giant cells" EXACT []
synonym: "seminiferous tubule giant cells" EXACT []
is_a: MP:0006362 ! abnormal male germ cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T19:06:29Z" xsd:dateTime

[Term]
id: MP:0020551
name: abnormal postsynaptic density morphology
def: "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse" [GO:0014069]
synonym: "abnormal neuronal post-synaptic density morphology" EXACT []
synonym: "abnormal neuronal postsynaptic density morphology" EXACT []
synonym: "abnormal post synaptic density morphology" EXACT []
synonym: "abnormal post-synaptic density morphology" EXACT []
synonym: "abnormal post-synaptic density of dendrite morphology" EXACT []
synonym: "abnormal postsynaptic density of dendrite morphology" EXACT []
is_a: MP:0020360 ! abnormal asymmetric synapse morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-12T20:00:34Z" xsd:dateTime

[Term]
id: MP:0020552
name: abnormal stria medullaris morphology
def: "any structural anomaly of a bundle of afferent fibers that form a ridge over the thalamus and project from the telensephalon to the habenular nucleus" [UBERON:0006086]
synonym: "abnormal stria medullaris of thalamus" EXACT []
is_a: MP:0000840 ! abnormal epithalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T16:57:13Z" xsd:dateTime

[Term]
id: MP:0020553
name: abnormal stria medullaris size
def: "a deviation from the normal size of the stria medullaris" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal stria medullaris of thalamus size" EXACT []
is_a: MP:0020552 ! abnormal stria medullaris morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T17:08:49Z" xsd:dateTime

[Term]
id: MP:0020554
name: decreased stria medullaris size
def: "decrease in the size of the stria medullaris" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased stria medullaris of thalamus size" EXACT []
is_a: MP:0020553 ! abnormal stria medullaris size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T17:09:01Z" xsd:dateTime

[Term]
id: MP:0020555
name: increased stria medullaris size
def: "increase in the size of the stria medullaris" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased stria medullaris of thalamus size" EXACT []
is_a: MP:0020553 ! abnormal stria medullaris size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T17:09:15Z" xsd:dateTime

[Term]
id: MP:0020556
name: abnormal ventromedial hypothalamic nucleus morphology
def: "any structural anomaly of a circumscript ovoid group of small neurons in the medial zone of the tuberal region of the hypothalamus delineated by a narrow, cell-sparse zone; this region regulates feeding, fear, thermoregulation and sexual activity" []
synonym: "abnormal ventromedial nucleus of hypothalamus morphology" EXACT []
synonym: "ventromedial hypothalamic nucleus dysplasia" NARROW []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T19:10:32Z" xsd:dateTime

[Term]
id: MP:0020557
name: abnormal ventromedial hypothalamic nucleus size
def: "a deviation from the normal size of the ventromedial hypothalamic nucleus" []
synonym: "abnormal ventromedial nucleus of hypothalamus size" EXACT []
is_a: MP:0020556 ! abnormal ventromedial hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T19:32:43Z" xsd:dateTime

[Term]
id: MP:0020558
name: decreased ventromedial hypothalamic nucleus size
def: "decrease in the size of the ventromedial hypothalamic nucleus" []
synonym: "decreased ventromedial nucleus of hypothalamus size" EXACT []
synonym: "reduced ventromedial hypothalamic nucleus size" EXACT []
synonym: "small ventromedial hypothalamic nucleus" EXACT []
is_a: MP:0020557 ! abnormal ventromedial hypothalamic nucleus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T19:32:56Z" xsd:dateTime

[Term]
id: MP:0020559
name: increased ventromedial hypothalamic nucleus size
def: "increase in the size of the ventromedial hypothalamic nucleus" []
synonym: "enlarged ventromedial hypothalamic nucleus" EXACT []
synonym: "increased ventromedial nucleus of hypothalamus size" EXACT []
is_a: MP:0020557 ! abnormal ventromedial hypothalamic nucleus size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T19:33:12Z" xsd:dateTime

[Term]
id: MP:0020560
name: abnormal pontine nuclei morphology
def: "any structural anomaly of nuclei in the basal pons, intermingled among the descending axons from the cortex, that receive neocortcial input and give rise to many axons that cross the midline to enter the contralateral cerebellum" [UBERON:0002151]
synonym: "abnormal griseum pontis morphology" EXACT []
synonym: "abnormal nuclei brachii pontis morphology" EXACT []
synonym: "abnormal nuclei pontis morphology" EXACT []
synonym: "abnormal nucleus pontis morphology" EXACT []
synonym: "abnormal pontine gray matter morphology" EXACT []
synonym: "abnormal pontine gray morphology" EXACT []
synonym: "abnormal pontine nuclear complex morphology" EXACT []
synonym: "abnormal pontine nuclear group morphology" EXACT []
is_a: MP:0000848 ! abnormal pons morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T19:59:56Z" xsd:dateTime

[Term]
id: MP:0020561
name: abnormal pontine nuclei size
def: "a deviation from the normal size of the pontine nuclei" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal griseum pontis size" EXACT []
is_a: MP:0020560 ! abnormal pontine nuclei morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:12:01Z" xsd:dateTime

[Term]
id: MP:0020562
name: decreased pontine nuclei size
def: "a decrease in the size of the pontine nuclei" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased griseum pontis size" EXACT []
synonym: "reduced pontine nuclei size" EXACT []
synonym: "small pontine nuclei" EXACT []
is_a: MP:0020561 ! abnormal pontine nuclei size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:14:38Z" xsd:dateTime

[Term]
id: MP:0020563
name: increased pontine nuclei size
def: "an increase in the size of the pontine nuclei" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged pontine nuclei" EXACT []
synonym: "increased griseum pontis size" EXACT []
is_a: MP:0020561 ! abnormal pontine nuclei size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:14:51Z" xsd:dateTime

[Term]
id: MP:0020564
name: abnormal pontocerebellar fibers morphology
def: "any structural anomaly of the fiber pathway in the metencephalon that project from the pons to the contralateral cerebellum" [UBERON:0022421, url:http\://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1345]
synonym: "abnormal fiber of pons morphology" EXACT []
synonym: "abnormal fibrae pontocerebellaris morphology" EXACT []
synonym: "abnormal fibre of pons morphology" EXACT []
synonym: "abnormal pontine crossing tract morphology" EXACT []
synonym: "abnormal pontocerebellar tract morphology" EXACT []
synonym: "abnormal tractus pontocerebellaris morphology" EXACT []
is_a: MP:0000848 ! abnormal pons morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:34:00Z" xsd:dateTime

[Term]
id: MP:0020565
name: abnormal pontocerebellar fibers size
def: "a deviation from the normal size of the pontocerebellar fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal fiber of pons size" EXACT []
synonym: "abnormal fibre of pons size" EXACT []
synonym: "abnormal pontocerebellar fibres size" EXACT []
is_a: MP:0020564 ! abnormal pontocerebellar fibers morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:39:24Z" xsd:dateTime

[Term]
id: MP:0020566
name: decreased pontocerebellar fibers size
def: "decrease in the size of the pontocerebellar fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased fiber of pons size" EXACT []
synonym: "decreased fibre of pons size" EXACT []
synonym: "decreased pontocerebellar fibres size" EXACT []
synonym: "reduced pontocerebellar fibers size" EXACT []
synonym: "reduced pontocerebellar fibres size" EXACT []
synonym: "small pontocerebellar fibers" EXACT []
synonym: "small pontocerebellar fibres" EXACT []
is_a: MP:0020565 ! abnormal pontocerebellar fibers size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:39:37Z" xsd:dateTime

[Term]
id: MP:0020567
name: increased pontocerebellar fibers size
def: "increase in the size of the pontocerebellar fibers" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged pontocerebellar fibers" EXACT []
synonym: "enlarged pontocerebellar fibres" EXACT []
synonym: "increased fiber of pons size" EXACT []
synonym: "increased fibre of pons size" EXACT []
synonym: "increased pontocerebellar fibres size" EXACT []
is_a: MP:0020565 ! abnormal pontocerebellar fibers size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T20:39:48Z" xsd:dateTime

[Term]
id: MP:0020568
name: abnormal premotor cortex morphology
def: "any structural anomaly of the part of the motor cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord; the premotor cortex influences movements of the face, neck and trunk, and upper and lower extremities" [UBERON:0016634, url:http\://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2331]
synonym: "abnormal nonprimary motor cortex morphology" EXACT []
synonym: "abnormal premotor area morphology" EXACT []
synonym: "abnormal secondary motor areas morphology" EXACT []
synonym: "abnormal secondary motor cortex morphology" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T21:13:54Z" xsd:dateTime

[Term]
id: MP:0020569
name: abnormal premotor cortex size
def: "any deviation from the normal size of the premotor cortex" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020568 ! abnormal premotor cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T21:27:10Z" xsd:dateTime

[Term]
id: MP:0020570
name: decreased premotor cortex size
def: "decrease in the size of the premotor cortex" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased secondary motor cortex size" EXACT []
synonym: "reduced secondary motor cortex size" EXACT []
synonym: "small premotor cortex" EXACT []
is_a: MP:0020569 ! abnormal premotor cortex size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T21:27:36Z" xsd:dateTime

[Term]
id: MP:0020571
name: increased premotor cortex size
def: "increase in the size of the premotor cortex" [https://orcid.org/0000-0003-4606-0597]
synonym: "enlarged premotor cortex" EXACT []
synonym: "increased secondary motor cortex size" EXACT []
is_a: MP:0020569 ! abnormal premotor cortex size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-02-26T21:27:50Z" xsd:dateTime

[Term]
id: MP:0020572
name: abnormal corpus callosum cell number
def: "any anomaly of the number of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597, PMID:20007460]
synonym: "abnormal corpus callosum cell count" EXACT []
is_a: MP:0000780 ! abnormal corpus callosum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-19T17:33:21Z" xsd:dateTime

[Term]
id: MP:0020573
name: abnormal corpus callosum size
def: "deviation from the average range of corpus callosum size compared to normal" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000780 ! abnormal corpus callosum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-19T17:43:20Z" xsd:dateTime

[Term]
id: MP:0020574
name: abnormal corpus callosum cell density
def: "any anomaly of the density of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000780 ! abnormal corpus callosum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-19T17:52:15Z" xsd:dateTime

[Term]
id: MP:0020575
name: increased corpus callosum cell number
def: "increase in the number of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020572 ! abnormal corpus callosum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-19T17:56:03Z" xsd:dateTime

[Term]
id: MP:0020576
name: decreased corpus callosum cell number
def: "decrease in the number of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020572 ! abnormal corpus callosum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-19T17:56:20Z" xsd:dateTime

[Term]
id: MP:0020577
name: abnormal pancreatic alpha cell number
def: "anomaly in the number of the cells of the pancreas that secrete glucagon" [https://orcid.org/0000-0002-4154-7358]
is_a: MP:0005216 ! abnormal pancreatic alpha cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T17:25:30Z" xsd:dateTime

[Term]
id: MP:0020578
name: abnormal pancreatic beta cell number
def: "anomaly in the number of the cells of the pancreas that secrete insulin" [https://orcid.org/0000-0002-4154-7358]
is_a: MP:0005217 ! abnormal pancreatic beta cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T17:29:04Z" xsd:dateTime

[Term]
id: MP:0020579
name: abnormal pancreatic delta cell number
def: "any anomaly in the number of the cells of the pancreas that secrete somatostatin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005218 ! abnormal pancreatic delta cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T17:31:45Z" xsd:dateTime

[Term]
id: MP:0020580
name: abnormal pancreatic epsilon cell number
def: "any anomaly in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009189 ! abnormal pancreatic epsilon cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T17:35:10Z" xsd:dateTime

[Term]
id: MP:0020581
name: abnormal neuron polarity
def: "any anomaly in the normal orientation or arrangement of the axon(s) and dendrite(s) in relation to the neuronal cell body" [https://orcid.org/0000-0003-4606-0597, PMID:26133936]
synonym: "abnormal axon-dendrite polarity of the neuron" EXACT []
is_a: MP:0002882 ! abnormal neuron morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T19:43:46Z" xsd:dateTime

[Term]
id: MP:0020582
name: increased ceramide level
def: "increased concentrations of ceramide" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated ceramide level" EXACT []
is_a: MP:0012232 ! abnormal ceramide level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T20:00:57Z" xsd:dateTime

[Term]
id: MP:0020583
name: decreased ceramide level
def: "decreased concentrations of ceramide" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced ceramide level" EXACT []
is_a: MP:0012232 ! abnormal ceramide level
is_a: MP:0014461 ! decreased lipid level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-03-26T20:01:10Z" xsd:dateTime

[Term]
id: MP:0020584
name: decreased corpus callosum cell density
def: "decrease in the density of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced corpus callosum cell density" EXACT []
is_a: MP:0020574 ! abnormal corpus callosum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:15:36Z" xsd:dateTime

[Term]
id: MP:0020585
name: increased corpus callosum cell density
def: "increase in the density of cells (mainly oligodendrocytes) of the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020574 ! abnormal corpus callosum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:15:50Z" xsd:dateTime

[Term]
id: MP:0020586
name: abnormal corpus callosum total cell area
def: "any anomaly in the measurement of all areas of cells contained in the corpus callosum" [WTSI:vancollie]
is_a: MP:0000780 ! abnormal corpus callosum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:20:37Z" xsd:dateTime

[Term]
id: MP:0020587
name: abnormal corpus callosum average cell area
def: "any anomaly in the measurement of all areas of cells contained in the corpus callosum divided by the total number of cells present in the corpus callosum" [WTSI:vancollie]
is_a: MP:0000780 ! abnormal corpus callosum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:20:50Z" xsd:dateTime

[Term]
id: MP:0020588
name: increased corpus callosum average cell area
def: "increase in the average of the total cell area contained in the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020587 ! abnormal corpus callosum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:27:16Z" xsd:dateTime

[Term]
id: MP:0020589
name: decreased corpus callosum average cell area
def: "decrease in the average of the total cell area contained in the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced corpus callosum average cell area" EXACT []
is_a: MP:0020587 ! abnormal corpus callosum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:27:36Z" xsd:dateTime

[Term]
id: MP:0020590
name: decreased corpus callosum total cell area
def: "decrease in the total area of all cells in the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced corpus callosum total cell area" EXACT []
is_a: MP:0020586 ! abnormal corpus callosum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:39:49Z" xsd:dateTime

[Term]
id: MP:0020591
name: increased corpus callosum total cell area
def: "increase in the total area of all cells in the corpus callosum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020586 ! abnormal corpus callosum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T17:40:00Z" xsd:dateTime

[Term]
id: MP:0020592
name: abnormal cerebral cortex cell number
def: "any anomaly of the number of cells of the cerebral cortex" [WTSI:vancollie]
synonym: "abnormal cerebral cortex cell count" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:00:47Z" xsd:dateTime

[Term]
id: MP:0020593
name: increased cerebral cortex cell number
def: "increase in the number of cells of the cerebral cortex" [WTSI:vancollie]
synonym: "increased cerebral cortex cell count" EXACT []
is_a: MP:0020592 ! abnormal cerebral cortex cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:01:11Z" xsd:dateTime

[Term]
id: MP:0020594
name: decreased cerebral cortex cell number
def: "decrease in the number of cells of the cerebral cortex" [WTSI:vancollie]
synonym: "decreased cerebral cortex cell count" EXACT []
synonym: "reduced cerebral cortex cell count" EXACT []
synonym: "reduced cerebral cortex cell number" EXACT []
is_a: MP:0020592 ! abnormal cerebral cortex cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:01:21Z" xsd:dateTime

[Term]
id: MP:0020595
name: abnormal cerebral cortex total cell area
def: "any anomaly in the measurement of all areas of cells contained in the cerebral cortex" [WTSI:vancollie]
is_a: MP:0000788 ! abnormal cerebral cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:10:17Z" xsd:dateTime

[Term]
id: MP:0020596
name: decreased cerebral cortex total cell area
def: "decrease in the total area of all cells contained in the cerebral cortex" [WTSI:vancollie]
synonym: "reduced cerebral cortex total cell area" EXACT []
is_a: MP:0020595 ! abnormal cerebral cortex total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:10:27Z" xsd:dateTime

[Term]
id: MP:0020597
name: increased cerebral cortex total cell area
def: "increase in the total area of all cells contained in the cerebral cortex" [WTSI:vancollie]
is_a: MP:0020595 ! abnormal cerebral cortex total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:10:38Z" xsd:dateTime

[Term]
id: MP:0020598
name: abnormal cerebral cortex cell density
def: "any anomaly of the density of cells of the cerebral cortex" [WTSI:vancollie]
is_a: MP:0000788 ! abnormal cerebral cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:16:22Z" xsd:dateTime

[Term]
id: MP:0020599
name: increased cerebral cortex cell density
def: "increase of the density of cells of the cerebral cortex" [WTSI:vancollie]
is_a: MP:0020598 ! abnormal cerebral cortex cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:16:35Z" xsd:dateTime

[Term]
id: MP:0020600
name: decreased cerebral cortex cell density
def: "decrease of the density of cells of the cerebral cortex" [WTSI:vancollie]
synonym: "reduced cerebral cortex cell density" EXACT []
is_a: MP:0020598 ! abnormal cerebral cortex cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:16:46Z" xsd:dateTime

[Term]
id: MP:0020601
name: abnormal cerebral cortex average cell area
def: "any anomaly in the measurement of all areas of cells contained in the cerebral cortex divided by the total number of cells present in the cerebral cortex" [WTSI:vancollie]
is_a: MP:0000788 ! abnormal cerebral cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:23:34Z" xsd:dateTime

[Term]
id: MP:0020602
name: decreased cerebral cortex average cell area
def: "decrease in the average of the total cell area contained in the cerebral cortex" [WTSI:vancollie]
synonym: "reduced cerebral cortex average cell area" EXACT []
is_a: MP:0020601 ! abnormal cerebral cortex average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:24:12Z" xsd:dateTime

[Term]
id: MP:0020603
name: increased cerebral cortex average cell area
def: "increase in the average of the total cell area contained in the cerebral cortex" [WTSI:vancollie]
is_a: MP:0020601 ! abnormal cerebral cortex average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T18:24:21Z" xsd:dateTime

[Term]
id: MP:0020604
name: abnormal thalamus cell number
def: "any anomaly of the number of cells of the thalamus" [WTSI:vancollie]
synonym: "abnormal number of thalamus cells" EXACT []
synonym: "abnormal thalamus cell count" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:24:19Z" xsd:dateTime

[Term]
id: MP:0020605
name: increased thalamus cell number
def: "increase in the number of cells in the thalamus" [WTSI:vancollie]
synonym: "increased number of thalamus cells" EXACT []
synonym: "increased thalamus cell count" EXACT []
is_a: MP:0020604 ! abnormal thalamus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:24:40Z" xsd:dateTime

[Term]
id: MP:0020606
name: decreased thalamus cell number
def: "decrease in the number of cells of the thalamus" [WTSI:vancollie]
synonym: "decreased number of thalamus cells" EXACT []
synonym: "decreased thalamus cell count" EXACT []
synonym: "reduced number of thalamus cells" EXACT []
synonym: "reduced thalamus cell count" EXACT []
synonym: "reduced thalamus cell number" EXACT []
is_a: MP:0020604 ! abnormal thalamus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:24:48Z" xsd:dateTime

[Term]
id: MP:0020607
name: abnormal thalamus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the thalamus" [WTSI:vancollie]
synonym: "abnormal total area of thalamus cells" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:33:06Z" xsd:dateTime

[Term]
id: MP:0020608
name: decreased thalamus total cell area
def: "decrease in the total area of all cells contained in the thalamus" [WTSI:vancollie]
synonym: "decreased total area of thalamus cells" EXACT []
synonym: "reduced thalamus total cell area" EXACT []
synonym: "reduced total area of thalamus cells" EXACT []
is_a: MP:0020607 ! abnormal thalamus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:33:17Z" xsd:dateTime

[Term]
id: MP:0020609
name: increased thalamus total cell area
def: "increase in the total area of all cells contained in the thalamus" [WTSI:vancollie]
synonym: "increased total area of thalamus cells" EXACT []
is_a: MP:0020607 ! abnormal thalamus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:33:26Z" xsd:dateTime

[Term]
id: MP:0020610
name: abnormal thalamus cell density
def: "any anomaly of the density of cells of the thalamus" [WTSI:vancollie]
synonym: "abnormal density of thalamus cells" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:38:15Z" xsd:dateTime

[Term]
id: MP:0020611
name: increased thalamus cell density
def: "increase of the density of cells of the thalamus" [WTSI:vancollie]
synonym: "increased density of thalamus cells" EXACT []
is_a: MP:0020610 ! abnormal thalamus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:38:30Z" xsd:dateTime

[Term]
id: MP:0020612
name: decreased thalamus cell density
def: "decrease of the density of cells of the thalamus" [WTSI:vancollie]
synonym: "decreased density of thalamus cells" EXACT []
synonym: "reduced density of thalamus cells" EXACT []
synonym: "reduced thalamus cell density" EXACT []
is_a: MP:0020610 ! abnormal thalamus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:38:45Z" xsd:dateTime

[Term]
id: MP:0020613
name: abnormal thalamus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the thalamus divided by the total number of cells present in the thalamus" [WTSI:vancollie]
synonym: "abnormal average area of thalamus cells" EXACT []
is_a: MP:0000832 ! abnormal thalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:49:02Z" xsd:dateTime

[Term]
id: MP:0020614
name: decreased thalamus average cell area
def: "decrease in the average of the total cell area contained in the thalamus" [WTSI:vancollie]
synonym: "decreased average area of thalamus cells" EXACT []
synonym: "reduced average area of thalamus cells" EXACT []
synonym: "reduced thalamus average cell area" EXACT []
is_a: MP:0020613 ! abnormal thalamus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:49:13Z" xsd:dateTime

[Term]
id: MP:0020615
name: increased thalamus average cell area
def: "increase in the average of the total cell area contained in the thalamus" [WTSI:vancollie]
synonym: "increased average area of thalamus cells" EXACT []
is_a: MP:0020613 ! abnormal thalamus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T19:49:31Z" xsd:dateTime

[Term]
id: MP:0020616
name: abnormal dorsal striatum cell number
def: "any anomaly of the number of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "abnormal caudate putamen cell count" EXACT []
synonym: "abnormal caudate putamen cell number" EXACT []
synonym: "abnormal number of caudate putamen cells" EXACT []
is_a: MP:0004102 ! abnormal dorsal striatum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:26:50Z" xsd:dateTime

[Term]
id: MP:0020617
name: decreased dorsal striatum cell number
def: "decrease in the number of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "decreased caudate putamen cell count" EXACT []
synonym: "decreased caudate putamen cell number" EXACT []
synonym: "reduced caudate putamen cell count" EXACT []
synonym: "reduced caudate putamen cell number" EXACT []
is_a: MP:0020616 ! abnormal dorsal striatum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:27:04Z" xsd:dateTime

[Term]
id: MP:0020618
name: increased dorsal striatum cell number
def: "increase in the number of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "increased caudate putamen cell count" EXACT []
synonym: "increased caudate putamen cell number" EXACT []
synonym: "increased number of caudate putamen cells" EXACT []
is_a: MP:0020616 ! abnormal dorsal striatum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:27:18Z" xsd:dateTime

[Term]
id: MP:0020619
name: abnormal dorsal striatum total cell area
def: "any anomaly in the measurement of all areas of cells contained in the dorsal striatum" [WTSI:vancollie]
synonym: "abnormal caudate putamen total cell area" EXACT []
synonym: "abnormal total area of caudate putamen cells" EXACT []
is_a: MP:0004102 ! abnormal dorsal striatum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:35:42Z" xsd:dateTime

[Term]
id: MP:0020620
name: increased dorsal striatum total cell area
def: "increase in the total area of all cells contained in dorsal striatum" [WTSI:vancollie]
synonym: "increased caudate putamen total cell area" EXACT []
synonym: "increased total area of caudate putamen cells" EXACT []
is_a: MP:0020619 ! abnormal dorsal striatum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:36:04Z" xsd:dateTime

[Term]
id: MP:0020621
name: decreased dorsal striatum total cell area
def: "decrease in the total area of all cells contained in dorsal striatum" [WTSI:vancollie]
synonym: "decreased caudate putamen total cell area" EXACT []
synonym: "decreased total area of caudate putamen cells" EXACT []
is_a: MP:0020619 ! abnormal dorsal striatum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:36:15Z" xsd:dateTime

[Term]
id: MP:0020622
name: abnormal dorsal striatum cell density
def: "any anomaly of the density of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "abnormal caudate putamen cell density" EXACT []
synonym: "abnormal density of caudate putamen cells" EXACT []
is_a: MP:0004102 ! abnormal dorsal striatum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:42:53Z" xsd:dateTime

[Term]
id: MP:0020623
name: increased dorsal striatum cell density
def: "increase of the density of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "increased caudate putamen cell density" EXACT []
synonym: "increased density of caudate putamen cells" EXACT []
is_a: MP:0020622 ! abnormal dorsal striatum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:43:18Z" xsd:dateTime

[Term]
id: MP:0020624
name: decreased dorsal striatum cell density
def: "decrease of the density of cells of the dorsal striatum" [WTSI:vancollie]
synonym: "decreased caudate putamen cell density" EXACT []
synonym: "decreased density of caudate putamen cells" EXACT []
is_a: MP:0020622 ! abnormal dorsal striatum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-09T20:43:28Z" xsd:dateTime

[Term]
id: MP:0020625
name: abnormal dorsal striatum average cell area
def: "any anomaly in the measurement of all areas of cells contained in the dorsal striatum divided by the total number of cells present in the dorsal striatum" [WTSI:vancollie]
synonym: "abnormal average area of caudate putamen cells" EXACT []
synonym: "abnormal caudate putamen average cell area" EXACT []
is_a: MP:0004102 ! abnormal dorsal striatum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T14:42:21Z" xsd:dateTime

[Term]
id: MP:0020626
name: decreased dorsal striatum average cell area
def: "decrease in the average of the total cell area contained in the dorsal striatum" [WTSI:vancollie]
synonym: "decreased average area of caudate putamen cells" EXACT []
synonym: "decreased caudate putamen average cell area" EXACT []
synonym: "reduced caudate putamen average cell area" EXACT []
synonym: "reduced dorsal striatum average cell area" EXACT []
is_a: MP:0020625 ! abnormal dorsal striatum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T14:43:31Z" xsd:dateTime

[Term]
id: MP:0020627
name: increased dorsal striatum average cell area
def: "increase in the average of the total cell area contained in the dorsal striatum" [WTSI:vancollie]
synonym: "increased average area of caudate putamen cells" EXACT []
synonym: "increased caudate putamen average cell area" EXACT []
is_a: MP:0020625 ! abnormal dorsal striatum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T14:44:07Z" xsd:dateTime

[Term]
id: MP:0020628
name: abnormal hippocampus cell number
def: "any anomaly of the number of cells of the hippocampus" [WTSI:vancollie]
synonym: "abnormal hippocampus cell count" EXACT []
synonym: "abnormal number of hippocampus cells" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:19:16Z" xsd:dateTime

[Term]
id: MP:0020629
name: decreased hippocampus cell number
def: "decrease in the number of cells of the hippocampus" [WTSI:vancollie]
synonym: "decreased hippocampus cell count" EXACT []
synonym: "decreased number of hippocampus cells" EXACT []
synonym: "reduced hippocampus cell count" EXACT []
synonym: "reduced hippocampus cell number" EXACT []
is_a: MP:0020628 ! abnormal hippocampus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:19:42Z" xsd:dateTime

[Term]
id: MP:0020630
name: increased hippocampus cell number
def: "increase in the number of cells of the hippocampus" [WTSI:vancollie]
synonym: "increased hippocampus cell count" EXACT []
synonym: "increased number of hippocampus cells" EXACT []
is_a: MP:0020628 ! abnormal hippocampus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:19:55Z" xsd:dateTime

[Term]
id: MP:0020631
name: abnormal hippocampus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampus" [WTSI:vancollie]
synonym: "abnormal total area of hippocampus cells" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:26:24Z" xsd:dateTime

[Term]
id: MP:0020632
name: decreased hippocampus total cell area
def: "decrease in the total area of all cells contained in the hippocampus" [WTSI:vancollie]
synonym: "decreased total area of hippocampus cells" EXACT []
synonym: "reduced hippocampus total cell area" EXACT []
synonym: "reduced total area of hippocampus cells" EXACT []
is_a: MP:0020631 ! abnormal hippocampus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:26:34Z" xsd:dateTime

[Term]
id: MP:0020633
name: increased hippocampus total cell area
def: "increase in the total area of all cells contained in the hippocampus" [WTSI:vancollie]
synonym: "increased total area of hippocampus cells" EXACT []
is_a: MP:0020631 ! abnormal hippocampus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:26:42Z" xsd:dateTime

[Term]
id: MP:0020634
name: abnormal hippocampus cell density
def: "any anomaly of the density of cells of the hippocampus" [WTSI:vancollie]
synonym: "abnormal density of hippocampus cells" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:38:17Z" xsd:dateTime

[Term]
id: MP:0020635
name: decreased hippocampus cell density
def: "decrease of the density of cells of the hippocampus" [WTSI:vancollie]
synonym: "decreased density of hippocampus cells" EXACT []
synonym: "reduced density of hippocampus cells" EXACT []
synonym: "reduced hippocampus cell density" EXACT []
is_a: MP:0020634 ! abnormal hippocampus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:38:26Z" xsd:dateTime

[Term]
id: MP:0020636
name: increased hippocampus cell density
def: "increase of the density of cells of the hippocampus" [WTSI:vancollie]
synonym: "increased density of hippocampus cells" EXACT []
is_a: MP:0020634 ! abnormal hippocampus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:38:35Z" xsd:dateTime

[Term]
id: MP:0020637
name: abnormal hippocampus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampus divided by the total number of cells present in the hippocampus" [WTSI:vancollie]
synonym: "abnormal average area of hippocampus cells" EXACT []
is_a: MP:0000807 ! abnormal hippocampus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:46:22Z" xsd:dateTime

[Term]
id: MP:0020638
name: decreased hippocampus average cell area
def: "decrease in the average of the total cell area contained in the hippocampus" [WTSI:vancollie]
synonym: "decreased average area of hippocampus cells" EXACT []
synonym: "reduced average area of hippocampus cells" EXACT []
synonym: "reduced hippocampus average cell area" EXACT []
is_a: MP:0020637 ! abnormal hippocampus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:46:32Z" xsd:dateTime

[Term]
id: MP:0020639
name: increased hippocampus average cell area
def: "increase in the average of the total cell area contained in the hippocampus" [WTSI:vancollie]
synonym: "increased average area of hippocampus cells" EXACT []
is_a: MP:0020637 ! abnormal hippocampus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:46:41Z" xsd:dateTime

[Term]
id: MP:0020640
name: abnormal hippocampal fimbria cell number
def: "any anomaly of the number of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "abnormal hippocampal fimbria cell count" EXACT []
synonym: "abnormal number of hippocampal fimbria cells" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:52:27Z" xsd:dateTime

[Term]
id: MP:0020641
name: decreased hippocampal fimbria cell number
def: "decrease in the number of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "decreased hippocampal fimbria cell count" EXACT []
synonym: "decreased number of hippocampal fimbria cells" EXACT []
synonym: "reduced hippocampal fimbria cell count" EXACT []
synonym: "reduced hippocampal fimbria cell number" EXACT []
synonym: "reduced number of hippocampal fimbria cells" EXACT []
is_a: MP:0020640 ! abnormal hippocampal fimbria cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:52:42Z" xsd:dateTime

[Term]
id: MP:0020642
name: increased hippocampal fimbria cell number
def: "increase in the number of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "increased hippocampal fimbria cell count" EXACT []
synonym: "increased number of hippocampal fimbria cells" EXACT []
is_a: MP:0020640 ! abnormal hippocampal fimbria cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T15:53:02Z" xsd:dateTime

[Term]
id: MP:0020643
name: abnormal hippocampal fimbria total cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampal fimbria" [WTSI:vancollie]
synonym: "abnormal total area of hippocampal fimbria cells" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:00:20Z" xsd:dateTime

[Term]
id: MP:0020644
name: decreased hippocampal fimbria total cell area
def: "decrease in the total area of all cells contained in the hippocampal fimbria" [WTSI:vancollie]
synonym: "decreased total area of hippocampal fimbria cells" EXACT []
synonym: "reduced hippocampal fimbria total cell area" EXACT []
synonym: "reduced total area of hippocampal fimbria cells" EXACT []
is_a: MP:0020643 ! abnormal hippocampal fimbria total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:00:30Z" xsd:dateTime

[Term]
id: MP:0020645
name: increased hippocampal fimbria total cell area
def: "increase in the total area of all cells contained in the hippocampal fimbria" [WTSI:vancollie]
synonym: "increased total area of hippocampal fimbria cells" EXACT []
is_a: MP:0020643 ! abnormal hippocampal fimbria total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:00:44Z" xsd:dateTime

[Term]
id: MP:0020646
name: abnormal hippocampal fimbria cell density
def: "any anomaly of the density of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "abnormal density of hippocampal fimbria cells" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:07:34Z" xsd:dateTime

[Term]
id: MP:0020647
name: decreased hippocampal fimbria cell density
def: "decrease of the density of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "decreased density of hippocampal fimbria cells" EXACT []
synonym: "reduced density of hippocampal fimbria cells" EXACT []
synonym: "reduced hippocampal fimbria cell density" EXACT []
is_a: MP:0020646 ! abnormal hippocampal fimbria cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:07:44Z" xsd:dateTime

[Term]
id: MP:0020648
name: increased hippocampal fimbria cell density
def: "increase of the density of cells of the hippocampal fimbria" [WTSI:vancollie]
synonym: "increased density of hippocampal fimbria cells" EXACT []
is_a: MP:0020646 ! abnormal hippocampal fimbria cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:07:54Z" xsd:dateTime

[Term]
id: MP:0020649
name: abnormal hippocampal fimbria average cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampal fimbria divided by the total number of cells present in the hippocampal fimbria" [WTSI:vancollie]
synonym: "abnormal average area of hippocampal fimbria cells" EXACT []
is_a: MP:0003005 ! abnormal hippocampal fimbria morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:15:22Z" xsd:dateTime

[Term]
id: MP:0020650
name: decreased hippocampal fimbria average cell area
def: "decrease in the average of the total cell area contained in the hippocampal fimbria" [WTSI:vancollie]
synonym: "decreased average area of hippocampal fimbria cells" EXACT []
synonym: "reduced average area of hippocampal fimbria cells" EXACT []
synonym: "reduced hippocampal fimbria average cell area" EXACT []
is_a: MP:0020649 ! abnormal hippocampal fimbria average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:15:34Z" xsd:dateTime

[Term]
id: MP:0020651
name: increased hippocampal fimbria average cell area
def: "increase in the average of the total cell area contained in the hippocampal fimbria" [WTSI:vancollie]
synonym: "increased average area of hippocampal fimbria cells" EXACT []
is_a: MP:0020649 ! abnormal hippocampal fimbria average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T16:15:46Z" xsd:dateTime

[Term]
id: MP:0020652
name: abnormal anterior commissure cell number
def: "any anomaly of the number of cells of the anterior commissure" [WTSI:vancollie]
synonym: "abnormal anterior commissure cell count" EXACT []
synonym: "abnormal number of anterior commissure cells" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:15:20Z" xsd:dateTime

[Term]
id: MP:0020653
name: decreased anterior commissure cell number
def: "decrease in the number of cells of the anterior commissure" [WTSI:vancollie]
synonym: "decreased anterior commissure cell count" EXACT []
synonym: "decreased number of anterior commissure cells" EXACT []
synonym: "reduced anterior commissure cell count" EXACT []
synonym: "reduced number of anterior commissure cells" EXACT []
is_a: MP:0020652 ! abnormal anterior commissure cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:15:35Z" xsd:dateTime

[Term]
id: MP:0020654
name: increased anterior commissure cell number
def: "increase in the number of cells of the anterior commissure" [WTSI:vancollie]
synonym: "increased anterior commissure cell count" EXACT []
synonym: "increased number of anterior commissure cells" EXACT []
is_a: MP:0020652 ! abnormal anterior commissure cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:15:49Z" xsd:dateTime

[Term]
id: MP:0020655
name: abnormal anterior commissure total cell area
def: "any anomaly in the measurement of all areas of cells contained in the anterior commissure" [WTSI:vancollie]
synonym: "abnormal total area of anterior commissure cells" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:21:51Z" xsd:dateTime

[Term]
id: MP:0020656
name: decreased anterior commissure total cell area
def: "decrease in the total area of all cells contained in the anterior commissure" [WTSI:vancollie]
synonym: "decreased total area of anterior commissure cells" EXACT []
is_a: MP:0020655 ! abnormal anterior commissure total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:22:00Z" xsd:dateTime

[Term]
id: MP:0020657
name: increased anterior commissure total cell area
def: "increase in the total area of all cells contained in the anterior commissure" [WTSI:vancollie]
synonym: "increased total area of anterior commissure cells" EXACT []
is_a: MP:0020655 ! abnormal anterior commissure total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:22:17Z" xsd:dateTime

[Term]
id: MP:0020658
name: abnormal anterior commissure cell density
def: "any anomaly of the density of cells of the anterior commissure" [WTSI:vancollie]
synonym: "abnormal density of anterior commissure cells" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:27:40Z" xsd:dateTime

[Term]
id: MP:0020659
name: decreased anterior commissure cell density
def: "decrease of the density of cells of the anterior commissure" [WTSI:vancollie]
synonym: "decreased density of anterior commissure cells" EXACT []
is_a: MP:0020658 ! abnormal anterior commissure cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:27:54Z" xsd:dateTime

[Term]
id: MP:0020660
name: increased anterior commissure cell density
def: "increase of the density of cells of the anterior commissure" [WTSI:vancollie]
synonym: "increased density of anterior commissure cells" EXACT []
is_a: MP:0020658 ! abnormal anterior commissure cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:28:06Z" xsd:dateTime

[Term]
id: MP:0020661
name: abnormal anterior commissure average cell area
def: "any anomaly in the measurement of all areas of cells contained in the anterior commissure divided by the total number of cells present in the anterior commissure" [WTSI:vancollie]
synonym: "abnormal average area of anterior commissure cells" EXACT []
is_a: MP:0008225 ! abnormal anterior commissure morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:32:24Z" xsd:dateTime

[Term]
id: MP:0020662
name: decreased anterior commissure average cell area
def: "decrease in the average of the total cell area contained in the anterior commissure" [WTSI:vancollie]
synonym: "decreased average area of anterior commissure cells" EXACT []
synonym: "reduced anterior commissure average cell area" EXACT []
synonym: "reduced average area of anterior commissure cells" EXACT []
is_a: MP:0020661 ! abnormal anterior commissure average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:32:34Z" xsd:dateTime

[Term]
id: MP:0020663
name: increased anterior commissure average cell area
def: "increase in the average of the total cell area contained in the anterior commissure" [WTSI:vancollie]
synonym: "increased average area of anterior commissure cells" EXACT []
is_a: MP:0020661 ! abnormal anterior commissure average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:32:44Z" xsd:dateTime

[Term]
id: MP:0020664
name: abnormal stria medullaris cell number
def: "any anomaly of the number of cells of the stria medullaris" [WTSI:vancollie]
synonym: "abnormal number of stria medullaris cells" EXACT []
synonym: "abnormal stria medullaris cell count" EXACT []
is_a: MP:0020552 ! abnormal stria medullaris morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:54:07Z" xsd:dateTime

[Term]
id: MP:0020665
name: decreased stria medullaris cell number
def: "decrease in the number of cells of the stria medullaris" [WTSI:vancollie]
synonym: "decreased number of stria medullaris cells" EXACT []
synonym: "decreased stria medullaris cell count" EXACT []
synonym: "reduced number of stria medullaris cells" EXACT []
synonym: "reduced stria medullaris cell count" EXACT []
synonym: "reduced stria medullaris cell number" EXACT []
is_a: MP:0020664 ! abnormal stria medullaris cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:54:21Z" xsd:dateTime

[Term]
id: MP:0020666
name: increased stria medullaris cell number
def: "increase in the number of cells of the stria medullaris" [WTSI:vancollie]
synonym: "increased number of stria medullaris cells" EXACT []
synonym: "increased stria medullaris cell count" EXACT []
is_a: MP:0020664 ! abnormal stria medullaris cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T17:54:36Z" xsd:dateTime

[Term]
id: MP:0020667
name: abnormal stria medullaris total cell area
def: "any anomaly in the measurement of all areas of cells contained in the stria medullaris" [WTSI:vancollie]
synonym: "abnormal total area of stria medullaris cells" EXACT []
is_a: MP:0020552 ! abnormal stria medullaris morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:00:56Z" xsd:dateTime

[Term]
id: MP:0020668
name: decreased stria medullaris total cell area
def: "decrease in the total area of all cells contained in the stria medullaris" [WTSI:vancollie]
synonym: "decreased total area of stria medullaris cells" EXACT []
synonym: "reduced stria medullaris total cell area" EXACT []
synonym: "reduced total area of stria medullaris cells" EXACT []
is_a: MP:0020667 ! abnormal stria medullaris total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:01:07Z" xsd:dateTime

[Term]
id: MP:0020669
name: increased stria medullaris total cell area
def: "increase in the total area of all cells contained in the stria medullaris" [WTSI:vancollie]
synonym: "increased total area of stria medullaris cells" EXACT []
is_a: MP:0020667 ! abnormal stria medullaris total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:01:17Z" xsd:dateTime

[Term]
id: MP:0020670
name: abnormal stria medullaris cell density
def: "any anomaly of the density of cells of the stria medullaris" [WTSI:vancollie]
synonym: "abnormal density of stria medullaris cells" EXACT []
is_a: MP:0020552 ! abnormal stria medullaris morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:07:20Z" xsd:dateTime

[Term]
id: MP:0020671
name: decreased stria medullaris cell density
def: "decrease of the density of cells of the stria medullaris" [WTSI:vancollie]
synonym: "decreased density of stria medullaris cells" EXACT []
synonym: "reduced density of stria medullaris cells" EXACT []
synonym: "reduced stria medullaris cell density" EXACT []
is_a: MP:0020670 ! abnormal stria medullaris cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:07:31Z" xsd:dateTime

[Term]
id: MP:0020672
name: increased stria medullaris cell density
def: "increase of the density of cells of the stria medullaris" [WTSI:vancollie]
synonym: "increased density of stria medullaris cells" EXACT []
is_a: MP:0020670 ! abnormal stria medullaris cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:07:42Z" xsd:dateTime

[Term]
id: MP:0020673
name: abnormal stria medullaris average cell area
def: "any anomaly in the measurement of all areas of cells contained in the stria medullaris divided by the total number of cells present in the stria medullaris" [WTSI:vancollie]
synonym: "abnormal average area of stria medullaris cells" EXACT []
is_a: MP:0020552 ! abnormal stria medullaris morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:12:48Z" xsd:dateTime

[Term]
id: MP:0020674
name: decreased stria medullaris average cell area
def: "decrease in the average of the total cell area contained in the stria medullaris" [WTSI:vancollie]
synonym: "decreased average area of stria medullaris cells" EXACT []
is_a: MP:0020673 ! abnormal stria medullaris average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:12:58Z" xsd:dateTime

[Term]
id: MP:0020675
name: increased stria medullaris average cell area
def: "increase in the average of the total cell area contained in the stria medullaris" [WTSI:vancollie]
synonym: "increased average area of stria medullaris cells" EXACT []
is_a: MP:0020673 ! abnormal stria medullaris average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:13:10Z" xsd:dateTime

[Term]
id: MP:0020676
name: abnormal hippocampal fornix cell number
def: "any anomaly of the number of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "abnormal fornix cell count" EXACT []
synonym: "abnormal number of fornix cells" EXACT []
is_a: MP:0003006 ! abnormal hippocampal fornix morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:30:05Z" xsd:dateTime

[Term]
id: MP:0020677
name: decreased hippocampal fornix cell number
def: "decrease in the number of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "decreased fornix cell count" EXACT []
synonym: "decreased number of fornix cells" EXACT []
synonym: "reduced fornix cell count" EXACT []
synonym: "reduced number of fornix cells" EXACT []
is_a: MP:0020676 ! abnormal hippocampal fornix cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:30:33Z" xsd:dateTime

[Term]
id: MP:0020678
name: increased hippocampal fornix cell number
def: "increase in the number of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "increased fornix cell count" EXACT []
synonym: "increased number of fornix cells" EXACT []
is_a: MP:0020676 ! abnormal hippocampal fornix cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:30:41Z" xsd:dateTime

[Term]
id: MP:0020679
name: abnormal hippocampal fornix total cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampal fornix" [WTSI:vancollie]
synonym: "abnormal fornix total cell area" EXACT []
synonym: "abnormal total area of fornix cells" EXACT []
is_a: MP:0003006 ! abnormal hippocampal fornix morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:36:07Z" xsd:dateTime

[Term]
id: MP:0020680
name: decreased hippocampal fornix total cell area
def: "decrease in the total area of all cells contained in the hippocampal fornix" [WTSI:vancollie]
synonym: "decreased fornix total cell area" EXACT []
synonym: "decreased total area of fornix cells" EXACT []
synonym: "reduced fornix total cell area" EXACT []
synonym: "reduced total area of fornix cells" EXACT []
is_a: MP:0020679 ! abnormal hippocampal fornix total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:36:25Z" xsd:dateTime

[Term]
id: MP:0020681
name: increased hippocampal fornix total cell area
def: "increase in the total area of all cells contained in the hippocampal fornix" [WTSI:vancollie]
synonym: "increased fornix total cell area" EXACT []
synonym: "increased total area of fornix cells" EXACT []
is_a: MP:0020679 ! abnormal hippocampal fornix total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:36:44Z" xsd:dateTime

[Term]
id: MP:0020682
name: abnormal hippocampal fornix cell density
def: "any anomaly of the density of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "abnormal density of fornix cells" EXACT []
is_a: MP:0003006 ! abnormal hippocampal fornix morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:42:05Z" xsd:dateTime

[Term]
id: MP:0020683
name: decreased hippocampal fornix cell density
def: "decrease of the density of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "decreased density of fornix cells" EXACT []
synonym: "decreased fornix cell density" EXACT []
synonym: "reduced density of fornix cells" EXACT []
synonym: "reduced fornix cell density" EXACT []
is_a: MP:0020682 ! abnormal hippocampal fornix cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:42:24Z" xsd:dateTime

[Term]
id: MP:0020684
name: increased hippocampal fornix cell density
def: "increase of the density of cells of the hippocampal fornix" [WTSI:vancollie]
synonym: "increased density of fornix cells" EXACT []
synonym: "increased fornix cell density" EXACT []
is_a: MP:0020682 ! abnormal hippocampal fornix cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:42:33Z" xsd:dateTime

[Term]
id: MP:0020685
name: abnormal hippocampal fornix average cell area
def: "any anomaly in the measurement of all areas of cells contained in the hippocampal fornix divided by the total number of cells present in the hippocampal fornix" [WTSI:vancollie]
synonym: "abnormal average area of fornix cells" EXACT []
synonym: "abnormal fornix average cell area" EXACT []
is_a: MP:0003006 ! abnormal hippocampal fornix morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:47:46Z" xsd:dateTime

[Term]
id: MP:0020686
name: decreased hippocampal fornix average cell area
def: "decrease in the average of the total cell area contained in the hippocampal fornix" [WTSI:vancollie]
synonym: "decreased average area of fornix cells" EXACT []
synonym: "decreased fornix average cell area" EXACT []
synonym: "reduced average area of fornix cells" EXACT []
synonym: "reduced fornix average cell area" EXACT []
is_a: MP:0020685 ! abnormal hippocampal fornix average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:48:02Z" xsd:dateTime

[Term]
id: MP:0020687
name: increased hippocampal fornix average cell area
def: "increase in the average of the total cell area contained in the hippocampal fornix" [WTSI:vancollie]
synonym: "increased average area of fornix cells" EXACT []
synonym: "increased fornix average cell area" EXACT []
is_a: MP:0020685 ! abnormal hippocampal fornix average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T18:55:42Z" xsd:dateTime

[Term]
id: MP:0020688
name: abnormal optic chiasm cell number
def: "any anomaly of the number of cells of the optic chiasm" [WTSI:vancollie]
synonym: "abnormal number of optic chiasm cells" EXACT []
synonym: "abnormal optic chiasm cell count" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:13:35Z" xsd:dateTime

[Term]
id: MP:0020689
name: decreased optic chiasm cell number
def: "decrease in the number of cells of the optic chiasm" [WTSI:vancollie]
synonym: "decreased number of optic chiasm cells" EXACT []
synonym: "decreased optic chiasm cell count" EXACT []
synonym: "reduced number of optic chiasm cells" EXACT []
synonym: "reduced optic chiasm cell count" EXACT []
is_a: MP:0020688 ! abnormal optic chiasm cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:13:49Z" xsd:dateTime

[Term]
id: MP:0020690
name: increased optic chiasm cell number
def: "increase in the number of cells of the optic chiasm" [WTSI:vancollie]
synonym: "increased number of optic chiasm cells" EXACT []
synonym: "increased optic chiasm cell count" EXACT []
is_a: MP:0020688 ! abnormal optic chiasm cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:14:02Z" xsd:dateTime

[Term]
id: MP:0020691
name: abnormal optic chiasm total cell area
def: "any anomaly in the measurement of all areas of cells contained in the optic chiasm" [WTSI:vancollie]
synonym: "abnormal total area of optic chiasm cells" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:18:49Z" xsd:dateTime

[Term]
id: MP:0020692
name: decreased optic chiasm total cell area
def: "decrease in the total area of all cells contained in the optic chiasm" [WTSI:vancollie]
synonym: "decreased total area of optic chiasm cells" EXACT []
is_a: MP:0020691 ! abnormal optic chiasm total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:19:00Z" xsd:dateTime

[Term]
id: MP:0020693
name: increased optic chiasm total cell area
def: "increase in the total area of all cells contained in the optic chiasm" [WTSI:vancollie]
synonym: "increased total area of optic chiasm cells" EXACT []
is_a: MP:0020691 ! abnormal optic chiasm total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:19:10Z" xsd:dateTime

[Term]
id: MP:0020694
name: abnormal optic chiasm cell density
def: "any anomaly of the density of cells of the optic chiasm" [WTSI:vancollie]
synonym: "abnormal density of optic chiasm cells" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:23:50Z" xsd:dateTime

[Term]
id: MP:0020695
name: decreased optic chiasm cell density
def: "decrease of the density of cells of the optic chiasm" [WTSI:vancollie]
synonym: "decreased density of optic chiasm cells" EXACT []
synonym: "reduced density of optic chiasm cells" EXACT []
synonym: "reduced optic chiasm cell density" EXACT []
is_a: MP:0020694 ! abnormal optic chiasm cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:24:01Z" xsd:dateTime

[Term]
id: MP:0020696
name: increased optic chiasm cell density
def: "increase of the density of cells of the optic chiasm" [WTSI:vancollie]
synonym: "increased density of optic chiasm cells" EXACT []
is_a: MP:0020694 ! abnormal optic chiasm cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:24:11Z" xsd:dateTime

[Term]
id: MP:0020697
name: abnormal optic chiasm average cell area
def: "any anomaly in the measurement of all areas of cells contained in the optic chiasm divided by the total number of cells present in the optic chiasm" [WTSI:vancollie]
synonym: "abnormal average area of optic chiasm cells" EXACT []
is_a: MP:0009770 ! abnormal optic chiasm morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:28:38Z" xsd:dateTime

[Term]
id: MP:0020698
name: decreased optic chiasm average cell area
def: "decrease in the average of the total cell area contained in the optic chiasm" [WTSI:vancollie]
synonym: "decreased average area of optic chiasm cells" EXACT []
synonym: "reduced average area of optic chiasm cells" EXACT []
synonym: "reduced optic chiasm average cell area" EXACT []
is_a: MP:0020697 ! abnormal optic chiasm average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:28:48Z" xsd:dateTime

[Term]
id: MP:0020699
name: increased optic chiasm average cell area
def: "increase in the average of the total cell area contained in the optic chiasm" [WTSI:vancollie]
synonym: "increased average area of optic chiasm cells" EXACT []
is_a: MP:0020697 ! abnormal optic chiasm average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:28:57Z" xsd:dateTime

[Term]
id: MP:0020700
name: abnormal ventromedial hypothalamic nucleus cell number
def: "any anomaly of the number of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "abnormal number of ventromedial hypothalamus cells" EXACT []
synonym: "abnormal ventromedial hypothalamus cell count" EXACT []
is_a: MP:0020556 ! abnormal ventromedial hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:50:05Z" xsd:dateTime

[Term]
id: MP:0020701
name: decreased ventromedial hypothalamic nucleus cell number
def: "decrease in the number of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "decreased number of ventromedial hypothalamus cells" EXACT []
synonym: "decreased ventromedial hypothalamus cell count" EXACT []
synonym: "reduced number of ventromedial hypothalamus cells" EXACT []
synonym: "reduced ventromedial hypothalamus cell count" EXACT []
is_a: MP:0020700 ! abnormal ventromedial hypothalamic nucleus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:50:34Z" xsd:dateTime

[Term]
id: MP:0020702
name: increased ventromedial hypothalamic nucleus cell number
def: "increase in the number of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "increased number of ventromedial hypothalamus cells" EXACT []
synonym: "increased ventromedial hypothalamus cell count" EXACT []
is_a: MP:0020700 ! abnormal ventromedial hypothalamic nucleus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:50:47Z" xsd:dateTime

[Term]
id: MP:0020703
name: abnormal ventromedial hypothalamic nucleus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "abnormal total area of ventromedial hypothalamus cells" EXACT []
synonym: "abnormal ventromedial hypothalamus total cell area" EXACT []
is_a: MP:0020556 ! abnormal ventromedial hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:57:03Z" xsd:dateTime

[Term]
id: MP:0020704
name: decreased ventromedial hypothalamic nucleus total cell area
def: "decrease in the total area of all cells contained in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "decreased total area of ventromedial hypothalamus cells" EXACT []
synonym: "decreased ventromedial hypothalamus total cell area" EXACT []
is_a: MP:0020703 ! abnormal ventromedial hypothalamic nucleus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:57:26Z" xsd:dateTime

[Term]
id: MP:0020705
name: increased ventromedial hypothalamic nucleus total cell area
def: "increase in the total area of all cells contained in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
is_a: MP:0020703 ! abnormal ventromedial hypothalamic nucleus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T19:57:40Z" xsd:dateTime

[Term]
id: MP:0020706
name: abnormal ventromedial hypothalamic nucleus cell density
def: "any anomaly of the density of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "abnormal density of ventromedial hypothalamus cells" EXACT []
synonym: "abnormal ventromedial hypothalamus cell density" EXACT []
is_a: MP:0020556 ! abnormal ventromedial hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:02:37Z" xsd:dateTime

[Term]
id: MP:0020707
name: decreased ventromedial hypothalamic nucleus cell density
def: "decrease of the density of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "decreased density of ventromedial hypothalamus cells" EXACT []
synonym: "decreased ventromedial hypothalamus cell density" EXACT []
synonym: "reduced density of ventromedial hypothalamus cells" EXACT []
synonym: "reduced ventromedial hypothalamus cell density" EXACT []
is_a: MP:0020706 ! abnormal ventromedial hypothalamic nucleus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:03:06Z" xsd:dateTime

[Term]
id: MP:0020708
name: increased ventromedial hypothalamic nucleus cell density
def: "increase of the density of cells of the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "increased density of ventromedial hypothalamus cells" EXACT []
synonym: "increased ventromedial hypothalamus cell density" EXACT []
is_a: MP:0020706 ! abnormal ventromedial hypothalamic nucleus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:03:13Z" xsd:dateTime

[Term]
id: MP:0020709
name: abnormal ventromedial hypothalamic nucleus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the ventromedial hypothalamic nucleus divided by the total number of cells present in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "abnormal average area of ventromedial hypothalamus cells" EXACT []
synonym: "abnormal ventromedial hypothalamus average cell area" EXACT []
is_a: MP:0020556 ! abnormal ventromedial hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:08:23Z" xsd:dateTime

[Term]
id: MP:0020710
name: decreased ventromedial hypothalamic nucleus average cell area
def: "decrease in the average of the total cell area contained in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "decreased average area of ventromedial hypothalamus cells" EXACT []
synonym: "decreased ventromedial hypothalamus average cell area" EXACT []
synonym: "reduced average area of ventromedial hypothalamus cells" EXACT []
synonym: "reduced ventromedial hypothalamus average cell area" EXACT []
is_a: MP:0020709 ! abnormal ventromedial hypothalamic nucleus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:08:43Z" xsd:dateTime

[Term]
id: MP:0020711
name: increased ventromedial hypothalamic nucleus average cell area
def: "increase in the average of the total cell area contained in the ventromedial hypothalamic nucleus" [WTSI:vancollie]
synonym: "increased average area of ventromedial hypothalamus cells" EXACT []
synonym: "increased ventromedial hypothalamus average cell area" EXACT []
is_a: MP:0020709 ! abnormal ventromedial hypothalamic nucleus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:09:07Z" xsd:dateTime

[Term]
id: MP:0020712
name: abnormal pontine nuclei cell number
def: "any anomaly of the number of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "abnormal number of pontine nuclei cells" EXACT []
synonym: "abnormal pontine nuclei cell count" EXACT []
is_a: MP:0020560 ! abnormal pontine nuclei morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:25:55Z" xsd:dateTime

[Term]
id: MP:0020713
name: decreased pontine nuclei cell number
def: "decrease in the number of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "decreased number of pontine nuclei cells" EXACT []
synonym: "decreased pontine nuclei cell count" EXACT []
synonym: "reduced number of pontine nuclei cells" EXACT []
synonym: "reduced pontine nuclei cell count" EXACT []
is_a: MP:0020712 ! abnormal pontine nuclei cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:26:18Z" xsd:dateTime

[Term]
id: MP:0020714
name: increased pontine nuclei cell number
def: "increase in the number of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "increased number of pontine nuclei cells" EXACT []
synonym: "increased pontine nuclei cell count" EXACT []
is_a: MP:0020712 ! abnormal pontine nuclei cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:26:29Z" xsd:dateTime

[Term]
id: MP:0020715
name: abnormal pontine nuclei total cell area
def: "any anomaly in the measurement of all areas of cells contained in the pontine nuclei" [WTSI:vancollie]
synonym: "abnormal total area of pontine nuclei cells" EXACT []
is_a: MP:0020560 ! abnormal pontine nuclei morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:33:14Z" xsd:dateTime

[Term]
id: MP:0020716
name: decreased pontine nuclei total cell area
def: "decrease in the total area of all cells contained in the pontine nuclei" [WTSI:vancollie]
synonym: "decreased total area of pontine nuclei cells" EXACT []
synonym: "reduced total area of pontine nuclei cells" EXACT []
is_a: MP:0020715 ! abnormal pontine nuclei total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:33:23Z" xsd:dateTime

[Term]
id: MP:0020717
name: increased pontine nuclei total cell area
def: "increase in the total area of all cells contained in the pontine nuclei" [WTSI:vancollie]
synonym: "increased total area of pontine nuclei cells" EXACT []
is_a: MP:0020715 ! abnormal pontine nuclei total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:33:32Z" xsd:dateTime

[Term]
id: MP:0020718
name: abnormal pontine nuclei cell density
def: "any anomaly of the density of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "abnormal density of pontine nuclei cells" EXACT []
is_a: MP:0020560 ! abnormal pontine nuclei morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:38:30Z" xsd:dateTime

[Term]
id: MP:0020719
name: decreased pontine nuclei cell density
def: "decrease of the density of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "decreased density of pontine nuclei cells" EXACT []
synonym: "reduced density of pontine nuclei cells" EXACT []
synonym: "reduced pontine nuclei cell density" EXACT []
is_a: MP:0020718 ! abnormal pontine nuclei cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:38:40Z" xsd:dateTime

[Term]
id: MP:0020720
name: increased pontine nuclei cell density
def: "increase of the density of cells of the pontine nuclei" [WTSI:vancollie]
synonym: "increased density of pontine nuclei cells" EXACT []
is_a: MP:0020718 ! abnormal pontine nuclei cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:38:50Z" xsd:dateTime

[Term]
id: MP:0020721
name: abnormal pontine nuclei average cell area
def: "any anomaly in the measurement of all areas of cells contained in the pontine nuclei divided by the total number of cells present in the pontine nuclei" [WTSI:vancollie]
synonym: "abnormal average area of pontine nuclei cells" EXACT []
is_a: MP:0020560 ! abnormal pontine nuclei morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:43:49Z" xsd:dateTime

[Term]
id: MP:0020722
name: decreased pontine nuclei average cell area
def: "decrease in the average of the total cell area contained in the pontine nuclei" [WTSI:vancollie]
synonym: "decreased average area of pontine nuclei cells" EXACT []
synonym: "reduced average area of pontine nuclei cells" EXACT []
synonym: "reduced pontine nuclei average cell area" EXACT []
is_a: MP:0020721 ! abnormal pontine nuclei average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:44:01Z" xsd:dateTime

[Term]
id: MP:0020723
name: increased pontine nuclei average cell area
def: "increase in the average of the total cell area contained in the pontine nuclei" [WTSI:vancollie]
synonym: "increased average area of pontine nuclei cells" EXACT []
is_a: MP:0020721 ! abnormal pontine nuclei average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-04-10T20:44:13Z" xsd:dateTime

[Term]
id: MP:0020724
name: thick retina inner nuclear layer
def: "increased thickness of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased retina inner nuclear layer thickness" EXACT []
synonym: "increased retinal INL thickness" EXACT []
synonym: "increased retinal inner nuclear layer thickness" EXACT []
synonym: "thick retinal inner nuclear layer" EXACT []
is_a: MP:0011996 ! abnormal retina inner nuclear layer thickness
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-15T15:47:44Z" xsd:dateTime

[Term]
id: MP:0020725
name: abnormal substantia nigra cell number
def: "any anomaly of the number of cells of the substantia nigra" [WTSI:vancollie]
synonym: "abnormal number of substantia nigra cells" EXACT []
synonym: "abnormal substantia nigra cell count" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:30:03Z" xsd:dateTime

[Term]
id: MP:0020726
name: decreased substantia nigra cell number
def: "decrease of the number of cells of the substantia nigra" [WTSI:vancollie]
synonym: "decreased number of substantia nigra cells" EXACT []
synonym: "decreased substantia nigra cell count" EXACT []
synonym: "reduced number of substantia nigra cells" EXACT []
synonym: "reduced substantia nigra cell count" EXACT []
is_a: MP:0020725 ! abnormal substantia nigra cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:32:19Z" xsd:dateTime

[Term]
id: MP:0020727
name: increased substantia nigra cell number
def: "increase of the number of cells of the substantia nigra" [WTSI:vancollie]
synonym: "elevated substantia nigra cell count" EXACT []
synonym: "increased number of substantia nigra cells" EXACT []
synonym: "increased substantia nigra cell count" EXACT []
is_a: MP:0020725 ! abnormal substantia nigra cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:32:31Z" xsd:dateTime

[Term]
id: MP:0020728
name: abnormal substantia nigra total cell area
def: "any anomaly in the measurement of all areas of cells contained in the substantia nigra" [WTSI:vancollie]
is_a: MP:0000836 ! abnormal substantia nigra morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:36:37Z" xsd:dateTime

[Term]
id: MP:0020729
name: decreased substantia nigra total cell area
def: "decrease in the total area of all cells contained in the substantia nigra" [WTSI:vancollie]
synonym: "decreased total area of substantia nigra cells" EXACT []
synonym: "reduced substantia nigra total cell area" EXACT []
synonym: "reduced total area of substantia nigra cells" EXACT []
is_a: MP:0020728 ! abnormal substantia nigra total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:36:57Z" xsd:dateTime

[Term]
id: MP:0020730
name: increased substantia nigra total cell area
def: "increase in the total area of all cells contained in the substantia nigra" [WTSI:vancollie]
synonym: "elevated substantia nigra total cell area" EXACT []
synonym: "elevated total area of substantia nigra cells" EXACT []
synonym: "increased total area of substantia nigra cells" EXACT []
is_a: MP:0020728 ! abnormal substantia nigra total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:37:07Z" xsd:dateTime

[Term]
id: MP:0020731
name: abnormal substantia nigra cell density
def: "any anomaly of the density of cells of the substantia nigra" [WTSI:vancollie]
synonym: "abnormal density of substantia nigra cells" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:42:09Z" xsd:dateTime

[Term]
id: MP:0020732
name: decreased substantia nigra cell density
def: "decrease of the density of cells of the substantia nigra" [WTSI:vancollie]
synonym: "decreased density of substantia nigra cells" EXACT []
synonym: "reduced density of substantia nigra cells" EXACT []
synonym: "reduced substantia nigra cell density" EXACT []
is_a: MP:0020731 ! abnormal substantia nigra cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:42:21Z" xsd:dateTime

[Term]
id: MP:0020733
name: increased substantia nigra cell density
def: "increase of the density of cells of the substantia nigra" [WTSI:vancollie]
synonym: "increased density of substantia nigra cells" EXACT []
is_a: MP:0020731 ! abnormal substantia nigra cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:42:31Z" xsd:dateTime

[Term]
id: MP:0020734
name: abnormal substantia nigra average cell area
def: "any anomaly in the measurement of all areas of cells contained in the  substantia nigra divided by the total number of cells present in the substantia nigra" [WTSI:vancollie]
synonym: "abnormal average area of substantia nigra cells" EXACT []
is_a: MP:0000836 ! abnormal substantia nigra morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:47:28Z" xsd:dateTime

[Term]
id: MP:0020735
name: decreased substantia nigra average cell area
def: "decrease in the measurement of all areas of cells contained in the  substantia nigra divided by the total number of cells present in the substantia nigra" [WTSI:vancollie]
synonym: "decreased average area of substantia nigra cells" EXACT []
synonym: "reduced average area of substantia nigra cells" EXACT []
synonym: "reduced substantia nigra average cell area" EXACT []
is_a: MP:0020734 ! abnormal substantia nigra average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:47:42Z" xsd:dateTime

[Term]
id: MP:0020736
name: increased substantia nigra average cell area
def: "increase in the measurement of all areas of cells contained in the  substantia nigra divided by the total number of cells present in the substantia nigra" [WTSI:vancollie]
synonym: "elevated average area of substantia nigra cells" EXACT []
synonym: "elevated substantia nigra average cell area" EXACT []
synonym: "increased average area of substantia nigra cells" EXACT []
is_a: MP:0020734 ! abnormal substantia nigra average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T14:47:53Z" xsd:dateTime

[Term]
id: MP:0020737
name: abnormal pontocerebellar fibers cell number
def: "any anomaly of the number of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "abnormal fiber of pons cell count" EXACT []
synonym: "abnormal fibrae pontocerebellaris cell count" EXACT []
synonym: "abnormal fibre of pons cell count" EXACT []
synonym: "abnormal number of pontocerebellar fibers cells" EXACT []
synonym: "abnormal pontine crossing tract cell count" EXACT []
synonym: "abnormal pontocerebellar fibers cell count" EXACT []
synonym: "abnormal pontocerebellar tract cell count" EXACT []
synonym: "abnormal tractus pontocerebellaris cell count" EXACT []
is_a: MP:0020564 ! abnormal pontocerebellar fibers morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:02:36Z" xsd:dateTime

[Term]
id: MP:0020738
name: decreased pontocerebellar fibers cell number
def: "decrease of the number of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "decreased fiber of pons cell count" EXACT []
synonym: "decreased fibrae pontocerebellaris cell count" EXACT []
synonym: "decreased fibre of pons cell count" EXACT []
synonym: "decreased pontine crossing tract cell count" EXACT []
synonym: "decreased pontocerebellar fibers cell count" EXACT []
synonym: "decreased pontocerebellar tract cell count" EXACT []
synonym: "decreased tractus pontocerebellaris cell count" EXACT []
synonym: "reduced fiber of pons cell count" EXACT []
synonym: "reduced fibrae pontocerebellaris cell count" EXACT []
synonym: "reduced fibre of pons cell count" EXACT []
synonym: "reduced pontine crossing tract cell count" EXACT []
synonym: "reduced pontocerebellar tract cell count" EXACT []
synonym: "reduced tractus pontocerebellaris cell count" EXACT []
is_a: MP:0020737 ! abnormal pontocerebellar fibers cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:02:51Z" xsd:dateTime

[Term]
id: MP:0020739
name: increased pontocerebellar fibers cell number
def: "increase of the number of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "increased fiber of pons cell count" EXACT []
synonym: "increased fibrae pontocerebellaris cell count" EXACT []
synonym: "increased fibre of pons cell count" EXACT []
synonym: "increased pontine crossing tract cell count" EXACT []
synonym: "increased pontocerebellar fibers cell count" EXACT []
synonym: "increased pontocerebellar tract cell count" EXACT []
synonym: "increased tractus pontocerebellaris cell count" EXACT []
is_a: MP:0020737 ! abnormal pontocerebellar fibers cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:03:05Z" xsd:dateTime

[Term]
id: MP:0020740
name: abnormal pontocerebellar fibers total cell area
def: "any anomaly of the total area of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "abnormal fiber of pons total cell area" EXACT []
synonym: "abnormal fibrae pontocerebellaris total cell area" EXACT []
synonym: "abnormal fibre of pons total cell area" EXACT []
synonym: "abnormal pontine crossing tract total cell area" EXACT []
synonym: "abnormal pontocerebellar tract cell area" EXACT []
synonym: "abnormal total area of pontocerebellar fiber cells" EXACT []
synonym: "abnormal tractus pontocerebellaris cell area" EXACT []
is_a: MP:0020564 ! abnormal pontocerebellar fibers morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:15:08Z" xsd:dateTime

[Term]
id: MP:0020741
name: decreased pontocerebellar fibers total cell area
def: "decrease of the total area of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "decreased fiber of pons total cell area" EXACT []
synonym: "decreased fibrae pontocerebellaris total cell area" EXACT []
synonym: "decreased fibre of pons total cell area" EXACT []
synonym: "decreased pontine crossing tract total cell area" EXACT []
synonym: "decreased pontocerebellar tract total cell area" EXACT []
synonym: "decreased tractus pontocerebellaris total cell area" EXACT []
synonym: "reduced fiber of pons total cell area" EXACT []
synonym: "reduced fibrae pontocerebellaris total cell area" EXACT []
synonym: "reduced fibre of pons total cell area" EXACT []
synonym: "reduced pontine crossing tract total cell area" EXACT []
synonym: "reduced pontocerebellar tract total cell area" EXACT []
synonym: "reduced tractus pontocerebellaris total cell area" EXACT []
is_a: MP:0020740 ! abnormal pontocerebellar fibers total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:15:20Z" xsd:dateTime

[Term]
id: MP:0020742
name: increased pontocerebellar fibers total cell area
def: "increase of the total area of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "increased fiber of pons total cell area" EXACT []
synonym: "increased fibrae pontocerebellaris total cell area" EXACT []
synonym: "increased fibre of pons total cell area" EXACT []
synonym: "increased pontine crossing tract total cell area" EXACT []
synonym: "increased pontocerebellar tract total cell area" EXACT []
synonym: "increased tractus pontocerebellaris total cell area" EXACT []
is_a: MP:0020740 ! abnormal pontocerebellar fibers total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:15:32Z" xsd:dateTime

[Term]
id: MP:0020743
name: abnormal pontocerebellar fibers cell density
def: "any anomaly of the density of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "abnormal density of pontocerebellar fiber cells" EXACT []
synonym: "abnormal fiber of pons cell density" EXACT []
synonym: "abnormal fibrae pontocerebellaris cell density" EXACT []
synonym: "abnormal fibre of pons cell density" EXACT []
synonym: "abnormal pontine crossing tract cell density" EXACT []
synonym: "abnormal pontocerebellar tract cell density" EXACT []
synonym: "abnormal tractus pontocerebellaris cell density" EXACT []
is_a: MP:0020564 ! abnormal pontocerebellar fibers morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:27:51Z" xsd:dateTime

[Term]
id: MP:0020744
name: decreased pontocerebellar fibers cell density
def: "decrease of the density of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "decreased fiber of pons cell density" EXACT []
synonym: "decreased fibrae pontocerebellaris cell density" EXACT []
synonym: "decreased fibre of pons cell density" EXACT []
synonym: "decreased pontine crossing tract cell density" EXACT []
synonym: "decreased pontocerebellar tract cell density" EXACT []
synonym: "decreased tractus pontocerebellaris cell density" EXACT []
synonym: "reduced fiber of pons cell density" EXACT []
synonym: "reduced fibrae pontocerebellaris cell density" EXACT []
synonym: "reduced fibre of pons cell density" EXACT []
synonym: "reduced pontine crossing tract cell density" EXACT []
synonym: "reduced pontocerebellar tract cell density" EXACT []
synonym: "reduced tractus pontocerebellaris cell density" EXACT []
is_a: MP:0020743 ! abnormal pontocerebellar fibers cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:28:04Z" xsd:dateTime

[Term]
id: MP:0020745
name: increased pontocerebellar fibers cell density
def: "increase of the density of cells of the pontocerebellar fibers" [WTSI:vancollie]
synonym: "increased fiber of pons cell density" EXACT []
synonym: "increased fibrae pontocerebellaris cell density" EXACT []
synonym: "increased fibre of pons cell density" EXACT []
synonym: "increased pontine crossing tract cell density" EXACT []
synonym: "increased pontocerebellar tract cell density" EXACT []
synonym: "increased tractus pontocerebellaris cell density" EXACT []
is_a: MP:0020743 ! abnormal pontocerebellar fibers cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:28:16Z" xsd:dateTime

[Term]
id: MP:0020746
name: abnormal pontocerebellar fibers average cell area
def: "any anomaly in the measurement of all areas of cells contained in the pontocerebellar fibers divided by the total number of cells present in the pontocerebellar fibers" [WTSI:vancollie]
synonym: "abnormal fiber of pons average cell area" EXACT []
synonym: "abnormal fibrae pontocerebellaris average cell area" EXACT []
synonym: "abnormal fibre of pons average cell area" EXACT []
synonym: "abnormal pontine crossing tract average cell area" EXACT []
synonym: "abnormal pontocerebellar tract average cell area" EXACT []
synonym: "abnormal tractus pontocerebellaris average cell area" EXACT []
is_a: MP:0020564 ! abnormal pontocerebellar fibers morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:38:30Z" xsd:dateTime

[Term]
id: MP:0020747
name: decreased pontocerebellar fibers average cell area
def: "decrease in the measurement of all areas of cells contained in the pontocerebellar fibers divided by the total number of cells present in the pontocerebellar fibers" [WTSI:vancollie]
synonym: "decreased fiber of pons average cell area" EXACT []
synonym: "decreased fibrae pontocerebellaris average cell area" EXACT []
synonym: "decreased fibre of pons average cell area" EXACT []
synonym: "decreased pontine crossing tract average cell area" EXACT []
synonym: "decreased pontocerebellar tract average cell area" EXACT []
synonym: "decreased tractus pontocerebellaris average cell area" EXACT []
synonym: "reduced fiber of pons average cell area" EXACT []
synonym: "reduced fibrae pontocerebellaris average cell area" EXACT []
synonym: "reduced fibre of pons average cell area" EXACT []
synonym: "reduced pontine crossing tract average cell area" EXACT []
synonym: "reduced pontocerebellar tract average cell area" EXACT []
synonym: "reduced tractus pontocerebellaris average cell area" EXACT []
is_a: MP:0020746 ! abnormal pontocerebellar fibers average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:38:43Z" xsd:dateTime

[Term]
id: MP:0020748
name: increased pontocerebellar fibers average cell area
def: "increase in the measurement of all areas of cells contained in the pontocerebellar fibers divided by the total number of cells present in the pontocerebellar fibers" [WTSI:vancollie]
synonym: "increased fiber of pons average cell area" EXACT []
synonym: "increased fibrae pontocerebellaris average cell area" EXACT []
synonym: "increased fibre of pons average cell area" EXACT []
synonym: "increased pontine crossing tract average cell area" EXACT []
synonym: "increased pontocerebellar tract average cell area" EXACT []
synonym: "increased tractus pontocerebellaris average cell area" EXACT []
is_a: MP:0020746 ! abnormal pontocerebellar fibers average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T15:38:55Z" xsd:dateTime

[Term]
id: MP:0020749
name: abnormal cingulate cortex morphology
def: "any structural anomaly of the thick belt of cortex encircling the corpus callosum that responsible for producing emotional responses to physical sensations of pain and for cognitive control" [https://orcid.org/0000-0003-3691-0324, PMID:21331082]
is_a: MP:0004169 ! abnormal fornicate gyrus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T18:59:11Z" xsd:dateTime

[Term]
id: MP:0020750
name: abnormal cingulate cortex cell number
def: "any anomaly of the number of cells of the cingulate cortex" [WTSI:vancollie]
synonym: "abnormal cingulate cortex cell count" EXACT []
synonym: "abnormal number of cingulate cortex cells" EXACT []
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:27:08Z" xsd:dateTime

[Term]
id: MP:0020751
name: decreased cingulate cortex cell number
def: "a decrease of the number of cells of the cingulate cortex" [WTSI:vancollie]
synonym: "decreased cingulate cortex cell count" EXACT []
synonym: "decreased number of cingulate cortex cells" EXACT []
synonym: "reduced cingulate cortex cell count" EXACT []
synonym: "reduced cingulate cortex cell number" EXACT []
synonym: "reduced number of cingulate cortex cells" EXACT []
is_a: MP:0020750 ! abnormal cingulate cortex cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:30:06Z" xsd:dateTime

[Term]
id: MP:0020752
name: increased cingulate cortex cell number
def: "an increase of the number of cells of the cingulate cortex" [WTSI:vancollie]
synonym: "increased cingulate cortex cell count" EXACT []
synonym: "increased number of cingulate cortex cells" EXACT []
is_a: MP:0020750 ! abnormal cingulate cortex cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:30:18Z" xsd:dateTime

[Term]
id: MP:0020753
name: abnormal cingulate cortex total cell area
def: "any anomaly in the measurement of all areas of cells contained in the cingulate cortex" [WTSI:vancollie]
synonym: "abnormal total area of cingulate cortex cells" EXACT []
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:42:32Z" xsd:dateTime

[Term]
id: MP:0020754
name: decreased cingulate cortex total cell area
def: "decrease in the measurement of all areas of cells contained in the cingulate cortex" [WTSI:vancollie]
synonym: "decreased total area of cingulate cortex cells" EXACT []
synonym: "reduced cingulate cortex total cell area" EXACT []
synonym: "reduced total area of cingulate cortex cells" EXACT []
is_a: MP:0020753 ! abnormal cingulate cortex total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:42:41Z" xsd:dateTime

[Term]
id: MP:0020755
name: increased cingulate cortex total cell area
def: "increase in the measurement of all areas of cells contained in the cingulate cortex" [WTSI:vancollie]
synonym: "increased total area of cingulate cortex cells" EXACT []
is_a: MP:0020753 ! abnormal cingulate cortex total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:42:51Z" xsd:dateTime

[Term]
id: MP:0020756
name: abnormal cingulate cortex cell density
def: "any anomaly of the density of cells of the cingulate cortex" [WTSI:vancollie]
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:48:03Z" xsd:dateTime

[Term]
id: MP:0020757
name: decreased cingulate cortex cell density
def: "decrease of the density of cells of the cingulate cortex" [WTSI:vancollie]
is_a: MP:0020756 ! abnormal cingulate cortex cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:48:13Z" xsd:dateTime

[Term]
id: MP:0020758
name: increased cingulate cortex cell density
def: "increase of the density of cells of the cingulate cortex" [WTSI:vancollie]
is_a: MP:0020756 ! abnormal cingulate cortex cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:48:23Z" xsd:dateTime

[Term]
id: MP:0020759
name: abnormal cingulate cortex average cell area
def: "any anomaly in the measurement of all areas of cells contained in the cingulate cortex divided by the total number of cells present in cingulate cortex" [WTSI:vancollie]
synonym: "abnormal average area of cingulate cortex cells" EXACT []
is_a: MP:0020749 ! abnormal cingulate cortex morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:52:03Z" xsd:dateTime

[Term]
id: MP:0020760
name: decreased cingulate cortex average cell area
def: "decrease in the measurement of all areas of cells contained in the cingulate cortex divided by the total number of cells present in cingulate cortex" [WTSI:vancollie]
synonym: "decreased average area of cingulate cortex cells" EXACT []
synonym: "reduced average area of cingulate cortex cells" EXACT []
synonym: "reduced cingulate cortex average cell area" EXACT []
is_a: MP:0020759 ! abnormal cingulate cortex average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:52:14Z" xsd:dateTime

[Term]
id: MP:0020761
name: increased cingulate cortex average cell area
def: "increase in the measurement of all areas of cells contained in the cingulate cortex divided by the total number of cells present in cingulate cortex" [WTSI:vancollie]
synonym: "increased average area of cingulate cortex cells" EXACT []
is_a: MP:0020759 ! abnormal cingulate cortex average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-16T19:52:25Z" xsd:dateTime

[Term]
id: MP:0020762
name: abnormal dorsal subiculum morphology
def: "the dorsal division of the subiculum; thought to play a role in the processing of spatial, mnemonic and movement information" [PMID:16185252, PMID:17317229]
is_a: MP:0008287 ! abnormal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T14:48:08Z" xsd:dateTime

[Term]
id: MP:0020763
name: abnormal dorsal subiculum cell number
def: "any anomaly of the number of cells of the dorsal subiculum" [WTSI:vancollie]
synonym: "abnormal dorsal subiculum cell count" EXACT []
synonym: "abnormal number of dorsal subiculum cells" EXACT []
is_a: MP:0020762 ! abnormal dorsal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:00:04Z" xsd:dateTime

[Term]
id: MP:0020764
name: decreased dorsal subiculum cell number
def: "decrease in the number of cells of the dorsal subiculum" [WTSI:vancollie]
synonym: "decreased dorsal subiculum cell count" EXACT []
synonym: "decreased number of dorsal subiculum cells" EXACT []
synonym: "reduced dorsal subiculum cell count" EXACT []
synonym: "reduced dorsal subiculum cell number" EXACT []
synonym: "reduced number of dorsal subiculum cells" EXACT []
is_a: MP:0020763 ! abnormal dorsal subiculum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:01:41Z" xsd:dateTime

[Term]
id: MP:0020765
name: increased dorsal subiculum cell number
def: "increase in the number of cells of the dorsal subiculum" [WTSI:vancollie]
synonym: "increased dorsal subiculum cell count" EXACT []
synonym: "increased number of dorsal subiculum cells" EXACT []
is_a: MP:0020763 ! abnormal dorsal subiculum cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:01:54Z" xsd:dateTime

[Term]
id: MP:0020766
name: abnormal dorsal subiculum total cell area
def: "any anomaly in the measurement of all areas of cells contained in the dorsal subiculum" [WTSI:vancollie]
synonym: "abnormal total area of dorsal subiculum cells" EXACT []
is_a: MP:0020762 ! abnormal dorsal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:05:52Z" xsd:dateTime

[Term]
id: MP:0020767
name: decreased dorsal subiculum total cell area
def: "decrease in the total area of all cells contained in the dorsal subiculum" [WTSI:vancollie]
synonym: "decreased total area of dorsal subiculum cells" EXACT []
synonym: "reduced dorsal subiculum total cell area" EXACT []
synonym: "reduced total area of dorsal subiculum cells" EXACT []
is_a: MP:0020766 ! abnormal dorsal subiculum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:06:05Z" xsd:dateTime

[Term]
id: MP:0020768
name: increased dorsal subiculum total cell area
def: "increase in the total area of all cells contained in the dorsal subiculum" [WTSI:vancollie]
synonym: "increased total area of dorsal subiculum cells" EXACT []
is_a: MP:0020766 ! abnormal dorsal subiculum total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:06:18Z" xsd:dateTime

[Term]
id: MP:0020769
name: abnormal dorsal subiculum cell density
def: "any anomaly of the density of cells of the dorsal subiculum" [WTSI:vancollie]
synonym: "abnormal density of dorsal subiculum cells" EXACT []
is_a: MP:0020762 ! abnormal dorsal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:11:52Z" xsd:dateTime

[Term]
id: MP:0020770
name: decreased dorsal subiculum cell density
def: "decrease of the density of cells of the dorsal subiculum" [WTSI:vancollie]
synonym: "decreased density of dorsal subiculum cells" EXACT []
synonym: "reduced density of dorsal subiculum cells" EXACT []
synonym: "reduced dorsal subiculum cell density" EXACT []
is_a: MP:0020769 ! abnormal dorsal subiculum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:12:02Z" xsd:dateTime

[Term]
id: MP:0020771
name: increased dorsal subiculum cell density
def: "increase of the density of cells of the dorsal subiculum" [WTSI:vancollie]
is_a: MP:0020769 ! abnormal dorsal subiculum cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:12:15Z" xsd:dateTime

[Term]
id: MP:0020772
name: abnormal dorsal subiculum average cell area
def: "any anomaly in the measurement of all areas of cells contained in the dorsal subiculum divided by the total number of cells present in the dorsal subiculum" [WTSI:vancollie]
synonym: "abnormal average area of dorsal subiculum cells" EXACT []
is_a: MP:0020762 ! abnormal dorsal subiculum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:23:41Z" xsd:dateTime

[Term]
id: MP:0020773
name: decreased dorsal subiculum average cell area
def: "decrease in the average of the total cell area contained in the dorsal subiculum" [WTSI:vancollie]
synonym: "decreased average area of dorsal subiculum cells" EXACT []
synonym: "reduced average area of dorsal subiculum cells" EXACT []
synonym: "reduced dorsal subiculum average cell area" EXACT []
is_a: MP:0020772 ! abnormal dorsal subiculum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:23:50Z" xsd:dateTime

[Term]
id: MP:0020774
name: increased dorsal subiculum average cell area
def: "increase in the average of the total cell area contained in the dorsal subiculum" [WTSI:vancollie]
synonym: "increased average area of dorsal subiculum cells" EXACT []
is_a: MP:0020772 ! abnormal dorsal subiculum average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:24:01Z" xsd:dateTime

[Term]
id: MP:0020775
name: abnormal inferior colliculus cell number
def: "any anomaly of the number of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "abnormal inferior colliculus cell count" EXACT []
synonym: "abnormal number of inferior colliculus cells" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:44:39Z" xsd:dateTime

[Term]
id: MP:0020776
name: decreased inferior colliculus cell number
def: "decrease in the number of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "decreased inferior colliculus cell count" EXACT []
synonym: "decreased number of inferior colliculus cells" EXACT []
synonym: "reduced inferior colliculus cell count" EXACT []
synonym: "reduced number of inferior colliculus cells" EXACT []
is_a: MP:0020775 ! abnormal inferior colliculus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:44:53Z" xsd:dateTime

[Term]
id: MP:0020777
name: increased inferior colliculus cell number
def: "increase in the number of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "increased inferior colliculus cell count" EXACT []
synonym: "increased number of inferior colliculus cells" EXACT []
is_a: MP:0020775 ! abnormal inferior colliculus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:45:05Z" xsd:dateTime

[Term]
id: MP:0020778
name: abnormal inferior colliculus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the inferior colliculus" [WTSI:vancollie]
is_a: MP:0000776 ! abnormal inferior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:50:04Z" xsd:dateTime

[Term]
id: MP:0020779
name: decreased inferior colliculus total cell area
def: "decrease in the total area of all cells contained in the inferior colliculus" [WTSI:vancollie]
is_a: MP:0020778 ! abnormal inferior colliculus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:50:13Z" xsd:dateTime

[Term]
id: MP:0020780
name: increased inferior colliculus total cell area
def: "increase in the total area of all cells contained in the inferior colliculus" [WTSI:vancollie]
is_a: MP:0020778 ! abnormal inferior colliculus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:50:22Z" xsd:dateTime

[Term]
id: MP:0020781
name: abnormal inferior colliculus cell density
def: "any anomaly of the density of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "abnormal density of inferior colliculus cells" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:54:07Z" xsd:dateTime

[Term]
id: MP:0020782
name: decreased inferior colliculus cell density
def: "decrease of the density of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "decreased density of inferior colliculus cells" EXACT []
synonym: "reduced density of inferior colliculus cells" EXACT []
synonym: "reduced inferior colliculus cell density" EXACT []
is_a: MP:0020781 ! abnormal inferior colliculus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:54:17Z" xsd:dateTime

[Term]
id: MP:0020783
name: increased inferior colliculus cell density
def: "increase of the density of cells of the inferior colliculus" [WTSI:vancollie]
synonym: "increased density of inferior colliculus cells" EXACT []
is_a: MP:0020781 ! abnormal inferior colliculus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:54:27Z" xsd:dateTime

[Term]
id: MP:0020784
name: abnormal inferior colliculus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the inferior colliculus divided by the total number of cells present in the inferior colliculus" [WTSI:vancollie]
synonym: "abnormal average area of inferior colliculus cells" EXACT []
is_a: MP:0000776 ! abnormal inferior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:58:24Z" xsd:dateTime

[Term]
id: MP:0020785
name: decreased inferior colliculus average cell area
def: "decrease in the average of the total cell area contained in the inferior colliculus" [WTSI:vancollie]
synonym: "decreased average area of inferior colliculus cells" EXACT []
synonym: "reduced average area of inferior colliculus cells" EXACT []
synonym: "reduced inferior colliculus average cell area" EXACT []
is_a: MP:0020784 ! abnormal inferior colliculus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:58:35Z" xsd:dateTime

[Term]
id: MP:0020786
name: increased inferior colliculus average cell area
def: "increase in the average of the total cell area contained in the inferior colliculus" [WTSI:vancollie]
synonym: "increased average area of inferior colliculus cells" EXACT []
is_a: MP:0020784 ! abnormal inferior colliculus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T15:58:46Z" xsd:dateTime

[Term]
id: MP:0020787
name: abnormal superior colliculus cell number
def: "any anomaly of the number of cells of the superior colliculus" [WTSI:vancollie]
synonym: "abnormal superior colliculus cell count" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:48:13Z" xsd:dateTime

[Term]
id: MP:0020788
name: decreased superior colliculus cell number
def: "decrease in the number of cells of the superior colliculus" [WTSI:vancollie]
synonym: "decreased number of superior colliculus cells" EXACT []
synonym: "decreased superior colliculus cell count" EXACT []
synonym: "reduced number of superior colliculus cells" EXACT []
synonym: "reduced superior colliculus cell count" EXACT []
is_a: MP:0020787 ! abnormal superior colliculus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:48:27Z" xsd:dateTime

[Term]
id: MP:0020789
name: increased superior colliculus cell number
def: "increase in the number of cells of the superior colliculus" [WTSI:vancollie]
synonym: "increased number of superior colliculus cells" EXACT []
synonym: "increased superior colliculus cell count" EXACT []
is_a: MP:0020787 ! abnormal superior colliculus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:48:41Z" xsd:dateTime

[Term]
id: MP:0020790
name: abnormal superior colliculus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the superior colliculus" [WTSI:vancollie]
synonym: "abnormal total area of superior colliculus cells" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:54:25Z" xsd:dateTime

[Term]
id: MP:0020791
name: decreased superior colliculus total cell area
def: "decrease in the total area of all cells contained in the superior colliculus" [WTSI:vancollie]
synonym: "decreased total area of superior colliculus cells" EXACT []
synonym: "reduced superior colliculus total cell area" EXACT []
synonym: "reduced total area of superior colliculus cells" EXACT []
is_a: MP:0020790 ! abnormal superior colliculus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:54:35Z" xsd:dateTime

[Term]
id: MP:0020792
name: increased superior colliculus total cell area
def: "increase in the total area of all cells contained in the superior colliculus" [WTSI:vancollie]
synonym: "increased total area of superior colliculus cells" EXACT []
is_a: MP:0020790 ! abnormal superior colliculus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:54:48Z" xsd:dateTime

[Term]
id: MP:0020793
name: abnormal superior colliculus cell density
def: "any anomaly of the density of cells of the superior colliculus" [WTSI:vancollie]
synonym: "abnormal density of superior colliculus cells" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:59:34Z" xsd:dateTime

[Term]
id: MP:0020794
name: decreased superior colliculus cell density
def: "decrease of the density of cells of the superior colliculus" [WTSI:vancollie]
synonym: "decreased density of superior colliculus cells" EXACT []
synonym: "reduced density of superior colliculus cells" EXACT []
synonym: "reduced superior colliculus cell density" EXACT []
is_a: MP:0020793 ! abnormal superior colliculus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:59:44Z" xsd:dateTime

[Term]
id: MP:0020795
name: increased superior colliculus cell density
def: "increase of the density of cells of the superior colliculus" [WTSI:vancollie]
synonym: "increased density of superior colliculus cells" EXACT []
is_a: MP:0020793 ! abnormal superior colliculus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T16:59:53Z" xsd:dateTime

[Term]
id: MP:0020796
name: abnormal superior colliculus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the superior colliculus divided by the total number of cells present in the superior colliculus" [WTSI:vancollie]
synonym: "abnormal average area of superior colliculus cells" EXACT []
is_a: MP:0000904 ! abnormal superior colliculus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:05:29Z" xsd:dateTime

[Term]
id: MP:0020797
name: decreased superior colliculus average cell area
def: "decrease in the average of the total cell area contained in the superior colliculus" [WTSI:vancollie]
synonym: "decreased average area of superior colliculus cells" EXACT []
synonym: "reduced average area of superior colliculus cells" EXACT []
synonym: "reduced superior colliculus average cell area" EXACT []
is_a: MP:0020796 ! abnormal superior colliculus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:05:38Z" xsd:dateTime

[Term]
id: MP:0020798
name: increased superior colliculus average cell area
def: "increase in the average of the total cell area contained in the superior colliculus" [WTSI:vancollie]
synonym: "increased average area of superior colliculus cells" EXACT []
is_a: MP:0020796 ! abnormal superior colliculus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:05:47Z" xsd:dateTime

[Term]
id: MP:0020799
name: abnormal cerebellum fastigial nucleus cell number
def: "any anomaly of the number of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "abnormal medial cerebellar nucleus cell count" EXACT []
synonym: "abnormal medial cerebellar nucleus cell number" EXACT []
synonym: "abnormal number of medial cerebellar nucleus cells" EXACT []
is_a: MP:0009983 ! abnormal cerebellum fastigial nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:25:59Z" xsd:dateTime

[Term]
id: MP:0020800
name: increased cerebellum fastigial nucleus cell number
def: "increase in the number of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "increased medial cerebellar nucleus cell count" EXACT []
synonym: "increased medial cerebellar nucleus cell number" EXACT []
synonym: "increased number of medial cerebellar nucleus cells" EXACT []
is_a: MP:0020799 ! abnormal cerebellum fastigial nucleus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:26:24Z" xsd:dateTime

[Term]
id: MP:0020801
name: decreased cerebellum fastigial nucleus cell number
def: "decrease in the number of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "decreased medial cerebellar nucleus cell count" EXACT []
synonym: "decreased medial cerebellar nucleus cell number" EXACT []
synonym: "decreased number of medial cerebellar nucleus cells" EXACT []
synonym: "reduced medial cerebellar nucleus cell count" EXACT []
synonym: "reduced number of medial cerebellar nucleus cells" EXACT []
is_a: MP:0020799 ! abnormal cerebellum fastigial nucleus cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:26:40Z" xsd:dateTime

[Term]
id: MP:0020802
name: abnormal cerebellum fastigial nucleus total cell area
def: "any anomaly in the measurement of all areas of cells contained in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "abnormal medial cerebellar nucleus total cell area" EXACT []
synonym: "abnormal total area of medial cerebellar nucleus cells" EXACT []
is_a: MP:0009983 ! abnormal cerebellum fastigial nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:33:20Z" xsd:dateTime

[Term]
id: MP:0020803
name: increased cerebellum fastigial nucleus total cell area
def: "increase in the total area of all cells contained in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "increased medial cerebellar nucleus total cell area" EXACT []
synonym: "increased total area of medial cerebellar nucleus cells" EXACT []
is_a: MP:0020802 ! abnormal cerebellum fastigial nucleus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:33:29Z" xsd:dateTime

[Term]
id: MP:0020804
name: decreased cerebellum fastigial nucleus total cell area
def: "decrease in the total area of all cells contained in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "decreased medial cerebellar nucleus total cell area" EXACT []
synonym: "decreased total area of medial cerebellar nucleus cells" EXACT []
synonym: "reduced medial cerebellar nucleus total cell area" EXACT []
synonym: "reduced total area of medial cerebellar nucleus cells" EXACT []
is_a: MP:0020802 ! abnormal cerebellum fastigial nucleus total cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:33:38Z" xsd:dateTime

[Term]
id: MP:0020805
name: abnormal cerebellum fastigial nucleus cell density
def: "any anomaly of the density of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "abnormal density of medial cerebellar nucleus cells" EXACT []
synonym: "abnormal medial cerebellar nucleus cell density" EXACT []
is_a: MP:0009983 ! abnormal cerebellum fastigial nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:45:25Z" xsd:dateTime

[Term]
id: MP:0020806
name: increased cerebellum fastigial nucleus cell density
def: "increase of the density of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
is_a: MP:0020805 ! abnormal cerebellum fastigial nucleus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:45:35Z" xsd:dateTime

[Term]
id: MP:0020807
name: decreased cerebellum fastigial nucleus cell density
def: "decrease of the density of cells of the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "decreased density of medial cerebellar nucleus cells" EXACT []
synonym: "decreased medial cerebellar nucleus cell density" EXACT []
synonym: "reduced cerebellum fastigial nucleus cell density" EXACT []
synonym: "reduced density of medial cerebellar nucleus cells" EXACT []
synonym: "reduced medial cerebellar nucleus cell density" EXACT []
is_a: MP:0020805 ! abnormal cerebellum fastigial nucleus cell density
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:45:43Z" xsd:dateTime

[Term]
id: MP:0020808
name: abnormal cerebellum fastigial nucleus average cell area
def: "any anomaly in the measurement of all areas of cells contained in the cerebellum fastigial nucleus divided by the total number of cells present in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "abnormal average area of medial cerebellar nucleus cells" EXACT []
synonym: "abnormal medial cerebellar nucleus average cell area" EXACT []
is_a: MP:0009983 ! abnormal cerebellum fastigial nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:51:56Z" xsd:dateTime

[Term]
id: MP:0020809
name: increased cerebellum fastigial nucleus average cell area
def: "increase in the average of the total cell area contained in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "increased average area of medial cerebellar nucleus cells" EXACT []
synonym: "increased medial cerebellar nucleus average cell area" EXACT []
is_a: MP:0020808 ! abnormal cerebellum fastigial nucleus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:52:06Z" xsd:dateTime

[Term]
id: MP:0020810
name: decreased cerebellum fastigial nucleus average cell area
def: "decrease in the average of the total cell area contained in the cerebellum fastigial nucleus" [WTSI:vancollie]
synonym: "decreased average area of medial cerebellar nucleus cells" EXACT []
synonym: "decreased medial cerebellar nucleus average cell area" EXACT []
synonym: "reduced average area of medial cerebellar nucleus cells" EXACT []
synonym: "reduced cerebellum fastigial nucleus average cell area" EXACT []
synonym: "reduced medial cerebellar nucleus average cell area" EXACT []
is_a: MP:0020808 ! abnormal cerebellum fastigial nucleus average cell area
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-17T17:52:25Z" xsd:dateTime

[Term]
id: MP:0020811
name: abnormal photoreceptor outer segment size
def: "deviation from the average range of photoreceptor outer segment size for an organism" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T19:37:56Z" xsd:dateTime

[Term]
id: MP:0020812
name: long photoreceptor outer segment
def: "increased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [https://orcid.org/0000-0003-3691-0324]
synonym: "elongated photoreceptor outer segment" EXACT []
synonym: "increased photoreceptor outer segment length" EXACT []
is_a: MP:0020811 ! abnormal photoreceptor outer segment size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T19:39:54Z" xsd:dateTime

[Term]
id: MP:0020813
name: abnormal photoreceptor outer segment disc membrane morphology
def: "any structural anomaly of the membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer" [GO:0097381]
synonym: "abnormal photoreceptor outer segment disk membrane morphology" EXACT []
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T19:44:28Z" xsd:dateTime

[Term]
id: MP:0020814
name: abnormal photoreceptor outer segment diameter
def: "any anomaly in the width of the cross-sectional distance that extends from one lateral edge of the photoreceptor outer segment through its center and to the opposite lateral edge" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020811 ! abnormal photoreceptor outer segment size
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T19:48:41Z" xsd:dateTime

[Term]
id: MP:0020815
name: abnormal photoreceptor outer segment number
def: "deviation from the normal number of the photoreceptor outer segments" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003729 ! abnormal photoreceptor outer segment morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T19:56:05Z" xsd:dateTime

[Term]
id: MP:0020816
name: decreased photoreceptor outer segment number
def: "decreased number of photoreceptor outer segments" []
synonym: "reduced photoreceptor outer segment number" EXACT []
is_a: MP:0020815 ! abnormal photoreceptor outer segment number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T20:01:13Z" xsd:dateTime

[Term]
id: MP:0020817
name: increased photoreceptor outer segment number
def: "increased number of photoreceptor outer segments" []
is_a: MP:0020815 ! abnormal photoreceptor outer segment number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-05-24T20:01:22Z" xsd:dateTime

[Term]
id: MP:0020818
name: abnormal anterior cerebral artery topology
def: "abnormal position of the anterior cerebral artery in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0013822 ! abnormal anterior cerebral artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:06:22Z" xsd:dateTime

[Term]
id: MP:0020819
name: abnormal common carotid artery topology
def: "abnormal position of the common carotid artery in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0012729 ! abnormal common carotid artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:10:01Z" xsd:dateTime

[Term]
id: MP:0020820
name: absent segment of superior cerebellar artery
def: "absence of a portion of the superior cerebellar artery" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0014015 ! abnormal superior cerebellar artery morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:18:17Z" xsd:dateTime

[Term]
id: MP:0020821
name: abnormal oculomotor nerve topology
def: "abnormal position of the oculomotor nerve in relation to other structures" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001061 ! abnormal oculomotor nerve morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:38:13Z" xsd:dateTime

[Term]
id: MP:0020822
name: absent masticatory muscles
def: "absence of all the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0004234 ! abnormal masticatory muscle morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:41:47Z" xsd:dateTime

[Term]
id: MP:0020823
name: absent pubic symphysis
def: "absence of the firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0009575 ! abnormal pubic symphysis morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:44:42Z" xsd:dateTime

[Term]
id: MP:0020824
name: abnormal testis tissue architecture
def: "any anomaly in the texture of the testicular tissue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001146 ! abnormal testis morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:47:55Z" xsd:dateTime

[Term]
id: MP:0020825
name: ectopic spleen
def: "a spleen located outside of its normal position" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000689 ! abnormal spleen morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:51:39Z" xsd:dateTime

[Term]
id: MP:0020826
name: increased oculomotor nerve neuroma incidence
def: "greater than the expected incidence of a tumor derived from cells of the oculomotor nerve" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased oculomoter Schwannoma incidence" NARROW []
is_a: MP:0010281 ! increased nervous system tumor incidence
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T15:57:38Z" xsd:dateTime

[Term]
id: MP:0020827
name: single Mullerian duct
def: "presence of only one Mullerian duct instead of the usual 2 ducts" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003826 ! abnormal Mullerian duct morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T16:03:31Z" xsd:dateTime

[Term]
id: MP:0020828
name: abnormal axon course
def: "any anomaly in the path taken by a process from the nerve cell body to a target" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal nerve fiber course" EXACT []
synonym: "abnormal nerve fibre course" EXACT []
is_a: MP:0005404 ! abnormal axon morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T17:32:08Z" xsd:dateTime

[Term]
id: MP:0020829
name: abnormal forebrain tissue architecture
def: "any anomaly in the texture of the forebrain tissue" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000783 ! abnormal forebrain morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-11T17:38:15Z" xsd:dateTime

[Term]
id: MP:0020830
name: abnormal jugular lymph sac morphology
def: "any structural anomaly in an embryonic lymph sac that forms at the junction of the future internal jugular/anterior cardinals and subclavian veins" [UBERON:0011765]
is_a: MP:0020495 ! abnormal embryonic lymph sac morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T14:47:21Z" xsd:dateTime

[Term]
id: MP:0020831
name: decreased jugular lymph sac number
def: "fewer than the expected number of jugular lymph sacs; typically there are two of these" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent jugular lymph sac" EXACT []
synonym: "single jugular lymph sac" EXACT []
is_a: MP:0020830 ! abnormal jugular lymph sac morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T14:50:40Z" xsd:dateTime

[Term]
id: MP:0020832
name: absent jugular lymph sacs
def: "absence of both of the jugular lymph sacs" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020831 ! decreased jugular lymph sac number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T14:53:35Z" xsd:dateTime

[Term]
id: MP:0020833
name: increased jugular lymph sac number
def: "greater than the expected number of jugular lymph sacs; typically there are two of these" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020830 ! abnormal jugular lymph sac morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T14:57:18Z" xsd:dateTime

[Term]
id: MP:0020834
name: abnormal citrulline metabolism
def: "any anomaly in the chemical reactions and pathways involving citrulline, including metabolic, catabolic and biosynthetic processes" [PMID:16773471, RGD:sjwang]
is_a: MP:0013242 ! abnormal amino acid metabolism
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T15:14:00Z" xsd:dateTime

[Term]
id: MP:0020835
name: abnormal circulating citrulline level
def: "aberrant concentration in the blood of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins" [GO:0000052, RGD:sjwang]
is_a: MP:0005311 ! abnormal circulating amino acid level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T15:21:26Z" xsd:dateTime

[Term]
id: MP:0020836
name: increased circulating citrulline level
def: "increase in the amount per unit of blood of citrulline" [RGD:sjwang]
synonym: "elevated plasma citrulline" NARROW []
synonym: "increased plasma citrulline" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0020835 ! abnormal circulating citrulline level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T15:21:47Z" xsd:dateTime

[Term]
id: MP:0020837
name: decreased circulating citrulline level
def: "reduction in the amount per unit of blood of citrulline" [RGD:sjwang]
synonym: "decreased plasma citrulline" NARROW []
synonym: "reduced plasma citrulline" NARROW []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0020835 ! abnormal circulating citrulline level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T15:22:07Z" xsd:dateTime

[Term]
id: MP:0020838
name: increased acute myeloid leukemia incidence
def: "higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal myelocytes" [https://orcid.org/0000-0002-4154-7358]
synonym: "increased acute granulocytic leukemia incidence" EXACT []
synonym: "increased acute myeloblastic leukemia incidence" EXACT []
synonym: "increased acute myelogenous leukemia incidence" EXACT []
synonym: "increased acute nonlymphocytic leukemia incidence" EXACT []
synonym: "increased AML incidence" EXACT []
synonym: "increased ANLL incidence" EXACT []
is_a: MP:0002026 ! increased leukemia incidence
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T15:53:30Z" xsd:dateTime

[Term]
id: MP:0020839
name: increased acute undifferentiated leukemia incidence
def: "higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation where the leukocytes are too immature to be able to be classified; manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal myelocytes" [PMID:23583447, url:https\://medical-dictionary.thefreedictionary.com/acute+undifferentiated+leukemia] {comment="https://orcid.org/0000-0002-4154-7358"}
synonym: "increased AUL incidence" EXACT []
synonym: "increased stem cell leukemia incidence" EXACT []
is_a: MP:0020838 ! increased acute myeloid leukemia incidence
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-06-22T16:00:23Z" xsd:dateTime

[Term]
id: MP:0020840
name: abnormal type I cell of carotid body morphology
def: "any structural anomaly of the round or oval neuroepithelial cells in the carotid body that contact other type I cells or capillaries and are capable of secreting a number of neurotransmitters" [CL:0002292, PMID:10846047, url:https\://en.wikipedia.org/wiki/Glomus_cell]
synonym: "abnormal carotid body glomus cell morphology" EXACT []
is_a: MP:0001001 ! abnormal chemoreceptor morphology
is_a: MP:0003437 ! abnormal carotid body morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T15:23:37Z" xsd:dateTime

[Term]
id: MP:0020841
name: abnormal supporting cell of carotid body morphology
def: "any structural anomaly of the supporting cells of the carotid body that have characteristics of glial cells and with processes that envelope the junctions between glomus cells and nerve endings" [CL:0002256, PMID:10846047]
synonym: "abnormal carotid body sustentacular cell morphology" EXACT []
is_a: MP:0003437 ! abnormal carotid body morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T15:23:58Z" xsd:dateTime

[Term]
id: MP:0020842
name: abnormal supporting cell of carotid body physiology
def: "any functional anomaly of the supporting cells of the carotid body that have characteristics of glial cells and with processes that envelope the junctions between glomus cells and nerve endings" [CL:0002256, PMID:10846047]
synonym: "abnormal carotid body sustentacular cell physiology" EXACT []
is_a: MP:0003438 ! abnormal carotid body physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T15:35:26Z" xsd:dateTime

[Term]
id: MP:0020843
name: abnormal type I cell of carotid body physiology
def: "any functional anomaly of the round or oval neuroepithelial cells in the carotid body that contact other type I cells or capillaries and are capable of secreting a number of neurotransmitters" [CL:0002292, PMID:10846047, url:https\://en.wikipedia.org/wiki/Glomus_cell]
synonym: "abnormal carotid body glomus cell physiology" EXACT []
is_a: MP:0003438 ! abnormal carotid body physiology
is_a: MP:0010055 ! abnormal sensory neuron physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T15:35:45Z" xsd:dateTime

[Term]
id: MP:0020844
name: abnormal pulmonary respiratory rate response
def: "any anomaly in the change in the number of breaths per minute induced by a stimulus" [https://orcid.org/0000-0003-4606-0597, PMID:26560302]
is_a: MP:0005572 ! abnormal pulmonary respiratory rate
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T17:44:01Z" xsd:dateTime

[Term]
id: MP:0020845
name: abnormal DNA-templated transcription
def: "any anomaly in the cellular synthesis of RNA on a template of DNA" [GO:0006351, PMID:27040500]
synonym: "abnormal cellular transcription" EXACT []
synonym: "abnormal DNA-dependent transcription" EXACT []
synonym: "abnormal transcription" EXACT []
is_a: MP:0005621 ! abnormal cell physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T18:03:42Z" xsd:dateTime

[Term]
id: MP:0020846
name: abnormal cell motility
def: "any anomaly in a process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another" [GO:0048870]
synonym: "abnormal cell mobility" EXACT []
is_a: MP:0005621 ! abnormal cell physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-07-02T18:27:06Z" xsd:dateTime

[Term]
id: MP:0020847
name: abnormal peroxisome physiology
def: "any functional anomaly of the small organelle enclosed by a single membrane that contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism" [GO:0005777]
synonym: "abnormal peroxisomal physiology" EXACT []
synonym: "abnormal peroxisome vesicle physiology" EXACT []
is_a: MP:0014241 ! abnormal intracellular organelle physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-01T17:30:11Z" xsd:dateTime

[Term]
id: MP:0020848
name: abnormal exocytosis
def: "any anomaly in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle" [GO:0006887]
is_a: MP:0008546 ! abnormal vesicle-mediated transport
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-01T17:39:23Z" xsd:dateTime

[Term]
id: MP:0020849
name: abnormal actin cytoskeleton morphology
def: "any anomaly in the structure of the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins" [GO:0015629]
is_a: MP:0020378 ! abnormal cell cytoskeleton morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-01T17:47:08Z" xsd:dateTime

[Term]
id: MP:0020850
name: abnormal microtubule cytoskeleton morphology
def: "any structural anomaly of the part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins" [GO:0015630]
is_a: MP:0020378 ! abnormal cell cytoskeleton morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-01T17:53:28Z" xsd:dateTime

[Term]
id: MP:0020851
name: abnormal vacuole morphology
def: "any structural anomaly in the closed structures, found only in eukaryotic cells, that are completely surrounded by unit membrane and contain liquid material" [GO:0005773]
is_a: MP:0014239 ! abnormal intracellular organelle morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-01T18:07:46Z" xsd:dateTime

[Term]
id: MP:0020852
name: abnormal olfactory behavior
def: "any anomaly in the actions, reactions, or performance of an organism in response to an odor" [GO:0042048]
synonym: "abnormal behavioral response to scent" EXACT []
synonym: "abnormal behavioral response to smell" EXACT []
synonym: "abnormal behavioural response to odour" EXACT []
synonym: "abnormal behavioural response to scent" EXACT []
synonym: "abnormal behavioural response to smell" EXACT []
synonym: "abnormal olfactory behaviour" EXACT []
is_a: MP:0014114 ! abnormal cognition
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-11T18:07:39Z" xsd:dateTime

[Term]
id: MP:0020853
name: abnormal cornea epithelium thickness
def: "anomaly in the width or number of cell layers of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal corneal epithelium thickness" EXACT []
is_a: MP:0006000 ! abnormal cornea epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:15:53Z" xsd:dateTime

[Term]
id: MP:0020854
name: increased cornea epithelium thickness
def: "increase in the width or number of cell layers of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased corneal epithelium thickness" EXACT []
is_a: MP:0020853 ! abnormal cornea epithelium thickness
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:22:19Z" xsd:dateTime

[Term]
id: MP:0020855
name: decreased cornea epithelium thickness
def: "decrease in the width or number of cell layers of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased corneal epithelium thickness" EXACT []
synonym: "reduced corneal epithelium thickness" EXACT []
is_a: MP:0020853 ! abnormal cornea epithelium thickness
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:22:35Z" xsd:dateTime

[Term]
id: MP:0020856
name: absent cornea epithelium
def: "absence of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597]
synonym: "absent corneal epithelium" EXACT []
is_a: MP:0006000 ! abnormal cornea epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:46:24Z" xsd:dateTime

[Term]
id: MP:0020857
name: cornea epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the corneal epithelium, typically resulting in increased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "corneal epithelium hyperplasia" EXACT []
synonym: "hyperplastic corneal epithelium" EXACT []
is_a: MP:0006000 ! abnormal cornea epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:51:19Z" xsd:dateTime

[Term]
id: MP:0020858
name: cornea epithelium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the corneal epithelium, typically resulting in decreased size" [https://orcid.org/0000-0003-4606-0597]
synonym: "corneal epithelium hypoplasia" EXACT []
synonym: "hypoplastic corneal epithelium" EXACT []
is_a: MP:0006000 ! abnormal cornea epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:51:36Z" xsd:dateTime

[Term]
id: MP:0020859
name: disorganized cornea epithelium
def: "derangement of the pattern of the smooth stratified squamous epithelium that covers the outer surface of the cornea" [https://orcid.org/0000-0003-4606-0597]
synonym: "disorganised corneal epithelium" EXACT []
synonym: "disorganized corneal epithelium" EXACT []
is_a: MP:0006000 ! abnormal cornea epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T15:58:42Z" xsd:dateTime

[Term]
id: MP:0020860
name: abnormal cornea physiology
def: "any functional anomaly of the transparent anterior portion of the fibrous coat of the eye that covers the iris, pupil, and anterior chamber; together with the lens, the cornea refracts light" [UBERON:0000964]
synonym: "abnormal cornea of camera-type eye physiology" EXACT []
synonym: "abnormal corneal physiology" EXACT []
synonym: "abnormal tarsal conjunctiva physiology" EXACT []
synonym: "abnormal tunica cornea physiology" EXACT []
is_a: MP:0005253 ! abnormal eye physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T18:15:27Z" xsd:dateTime

[Term]
id: MP:0020861
name: abnormal cornea wound healing
def: "aberrant process of repair of trauma to the cornea, especially that caused by physical means" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal corneal wound healing" EXACT []
is_a: MP:0005023 ! abnormal wound healing
is_a: MP:0020860 ! abnormal cornea physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T18:20:42Z" xsd:dateTime

[Term]
id: MP:0020862
name: increased cornea fragility
def: "increase in the susceptibility of the cornea to damage or rupture" [https://medical-dictionary.thefreedictionary.com/corneal+fragility]
synonym: "fragile cornea" EXACT []
synonym: "increased corneal fragility" EXACT []
is_a: MP:0020860 ! abnormal cornea physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-17T18:26:52Z" xsd:dateTime

[Term]
id: MP:0020863
name: abnormal suckling reflex
def: "any anomaly in the ability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [https://www.medicinenet.com/script/main/art.asp?articlekey=5392]
synonym: "abnormal rooting reflex" EXACT []
synonym: "abnormal rooting response" EXACT []
is_a: MP:0001436 ! abnormal suckling behavior
is_a: MP:0001961 ! abnormal reflex
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-18T18:53:45Z" xsd:dateTime

[Term]
id: MP:0020864
name: premature suckling reflex loss
def: "cessation of the suckling reflex occurs earlier in development compared to controls" [https://orcid.org/0000-0003-4606-0597]
synonym: "premature rooting reflex loss" EXACT []
synonym: "premature rooting response loss" EXACT []
is_a: MP:0020863 ! abnormal suckling reflex
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-18T18:57:59Z" xsd:dateTime

[Term]
id: MP:0020865
name: delayed suckling reflex loss
def: "cessation of the suckling reflex occurs later in development compared to controls" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed rooting reflex loss" EXACT []
synonym: "delayed rooting response loss" EXACT []
is_a: MP:0020863 ! abnormal suckling reflex
is_a: MP:0021165 ! behavioral developmental delay
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-10-18T18:58:25Z" xsd:dateTime

[Term]
id: MP:0020866
name: abnormal lipogenesis
def: "any anomaly in the chemical reactions and pathways resulting in the formation of lipids" [GO:0008610]
synonym: "abnormal lipid anabolism" EXACT []
synonym: "abnormal lipid biosynthesis" EXACT []
synonym: "abnormal lipid biosynthetic process" EXACT []
synonym: "abnormal lipid formation" EXACT []
synonym: "abnormal lipid synthesis" EXACT []
is_a: MP:0013245 ! abnormal lipid metabolism
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-12-11T16:26:09Z" xsd:dateTime

[Term]
id: MP:0020867
name: increased lipogenesis
def: "any anomaly in the chemical reactions and pathways resulting in the formation of lipids that results in increased formation of lipids" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated lipogenesis" EXACT []
synonym: "increased lipid anabolism" EXACT []
synonym: "increased lipid biosynthesis" EXACT []
synonym: "increased lipid formation" EXACT []
synonym: "increased lipid synthesis" EXACT []
is_a: MP:0020866 ! abnormal lipogenesis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-12-11T16:43:29Z" xsd:dateTime

[Term]
id: MP:0020868
name: decreased lipogenesis
def: "any anomaly in the chemical reactions and pathways resulting in the formation of lipids that results in decreased formation of lipids" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased lipid anabolism" EXACT []
synonym: "decreased lipid biosynthesis" EXACT []
synonym: "decreased lipid formation" EXACT []
synonym: "decreased lipid synthesis" EXACT []
synonym: "reduced lipogenesis" EXACT []
is_a: MP:0020866 ! abnormal lipogenesis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-12-11T16:43:41Z" xsd:dateTime

[Term]
id: MP:0020869
name: immotile sperm
def: "complete absence of sperm motility" [https://orcid.org/0000-0003-4606-0597, PMID:16920728]
is_a: MP:0002675 ! asthenozoospermia
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2018-12-11T18:42:24Z" xsd:dateTime

[Term]
id: MP:0020870
name: decreased thigmotaxis
def: "less than average preference for staying at the perimeter walls of an open area or in an enclosed versus exposed area; may be used as an indicator of increased anxiety response" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001364 ! decreased anxiety-related response

[Term]
id: MP:0020871
name: abnormal locomotor response to cocaine
def: "any anomaly in locomotor activity following an acute or repeated exposure to the psychostimulant cocaine" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0001392 ! abnormal locomotor behavior
is_a: MP:0020158 ! abnormal behavioral response to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:08:05Z" xsd:dateTime

[Term]
id: MP:0020872
name: abnormal hypothalamic nucleus morphology
def: "any structural anomaly of one or more of the nuclei of the brain that are part of the hypothalamus" [UBERON:0006568]
synonym: "abnormal nucleus of the hypothalamus morphology" EXACT []
is_a: MP:0000837 ! abnormal hypothalamus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-04-29T18:05:24Z" xsd:dateTime

[Term]
id: MP:0020873
name: abnormal arcuate nucleus of hypothalamus morphology
def: "any structural anomaly of the aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence" [https://www.sciencedirect.com/topics/neuroscience/arcuate-nucleus, UBERON:0001932]
synonym: "abnormal ArcH morphology" EXACT []
synonym: "abnormal arcuate hypothalamic nucleus morphology" EXACT []
synonym: "abnormal arcuate periventricular nucleus morphology" EXACT []
synonym: "abnormal infundibular hypothalamic nucleus morphology" EXACT []
synonym: "abnormal infundibular nucleus morphology" EXACT []
synonym: "abnormal nucleus infundibularis morphology" EXACT []
is_a: MP:0020872 ! abnormal hypothalamic nucleus morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-04-29T18:13:31Z" xsd:dateTime

[Term]
id: MP:0020874
name: abnormal nervous system dopamine level
def: "aberrant concentration of dopamine in the one or more tissues or fluids of the nervous system" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001905 ! abnormal dopamine level
is_a: MP:0003632 ! abnormal nervous system morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-05-31T15:33:26Z" xsd:dateTime

[Term]
id: MP:0020875
name: decreased nervous system dopamine level
def: "reduced concentration of dopamine in the one or more tissues or fluids of the nervous system" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced nervous system dopamine level" EXACT []
is_a: MP:0005643 ! decreased dopamine level
is_a: MP:0020874 ! abnormal nervous system dopamine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-05-31T15:40:30Z" xsd:dateTime

[Term]
id: MP:0020876
name: increased nervous system dopamine level
def: "elevated concentration of dopamine in the one or more tissues or fluids of the nervous system" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated nervous system dopamine level" EXACT []
is_a: MP:0001906 ! increased dopamine level
is_a: MP:0020874 ! abnormal nervous system dopamine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-05-31T15:40:50Z" xsd:dateTime

[Term]
id: MP:0020877
name: decreased circulating dopamine level
def: "less than the normal blood amount of dopamine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced circulating dopamine level" EXACT []
is_a: MP:0005643 ! decreased dopamine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-05-31T16:05:49Z" xsd:dateTime

[Term]
id: MP:0020878
name: abnormal milk mineral level
def: "any anomaly in the concentration of one or more minerals in the milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0004047 ! abnormal milk composition
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T17:34:32Z" xsd:dateTime

[Term]
id: MP:0020879
name: abnormal calcium level
def: "any anomaly in the concentration of calcium in the body or bodily fluids" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0004231 ! abnormal calcium ion homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T17:40:58Z" xsd:dateTime

[Term]
id: MP:0020880
name: abnormal milk calcium level
def: "any anomaly in the concentration in the milk of calcium" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020879 ! abnormal calcium level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T17:48:56Z" xsd:dateTime

[Term]
id: MP:0020881
name: abnormal milk copper level
def: "any anomaly in the concentration of copper in the milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0003952 ! abnormal copper level
is_a: MP:0020878 ! abnormal milk mineral level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T17:57:06Z" xsd:dateTime

[Term]
id: MP:0020882
name: abnormal milk iron level
def: "any anomaly in the concentration of iron in the milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0001770 ! abnormal iron level
is_a: MP:0020878 ! abnormal milk mineral level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:01:54Z" xsd:dateTime

[Term]
id: MP:0020883
name: abnormal magnesium level
def: "any anomaly in the concentration of magnesium in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011979 ! abnormal magnesium ion homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:05:13Z" xsd:dateTime

[Term]
id: MP:0020884
name: abnormal milk magnesium level
def: "any anomaly in the concentration of magnesium in milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020883 ! abnormal magnesium level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:21:21Z" xsd:dateTime

[Term]
id: MP:0020885
name: abnormal phosphate level
def: "any anomaly in the concentration of phosphate (salt or ester of phosphoric acid) in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:24:50Z" xsd:dateTime

[Term]
id: MP:0020886
name: abnormal milk phosphate level
def: "any anomaly in the milk concentrations of the salt or ester of phosphoric acid" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020885 ! abnormal phosphate level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:32:01Z" xsd:dateTime

[Term]
id: MP:0020887
name: abnormal potassium level
def: "any anomaly in the concentration of potassium in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011978 ! abnormal potassium ion homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:35:20Z" xsd:dateTime

[Term]
id: MP:0020888
name: abnormal milk potassium level
def: "any anomaly in the concentration of potassium in milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020887 ! abnormal potassium level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:38:48Z" xsd:dateTime

[Term]
id: MP:0020889
name: abnormal sodium level
def: "any anomaly in the concentration of sodium in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0011977 ! abnormal sodium ion homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:42:23Z" xsd:dateTime

[Term]
id: MP:0020890
name: abnormal milk sodium level
def: "any anomaly in the concentration of sodium in milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020889 ! abnormal sodium level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:46:52Z" xsd:dateTime

[Term]
id: MP:0020891
name: abnormal sulfate level
def: "any anomaly in the concentration of sulfate (sulfur) in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:50:41Z" xsd:dateTime

[Term]
id: MP:0020892
name: abnormal milk sulfate level
def: "any anomaly in the concentration of sulfate (sulfur) in milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020891 ! abnormal sulfate level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:54:43Z" xsd:dateTime

[Term]
id: MP:0020893
name: abnormal zinc level
def: "any anomaly in the concentration of zinc in the body" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0009615 ! abnormal zinc homeostasis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T18:58:25Z" xsd:dateTime

[Term]
id: MP:0020894
name: abnormal milk zinc level
def: "any anomaly in the concentration of zinc in milk" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020878 ! abnormal milk mineral level
is_a: MP:0020893 ! abnormal zinc level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-06-06T19:06:04Z" xsd:dateTime

[Term]
id: MP:0020895
name: abnormal acute locomotor response to cocaine
def: "any anomaly in the expected locomotor response to a single exposure to cocaine in a drug-naive animal" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0020871 ! abnormal locomotor response to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:13:52Z" xsd:dateTime

[Term]
id: MP:0020896
name: abnormal locomotor sensitization to cocaine
def: "any anomaly in the expected increase in locomotor activation to cocaine upon repeated exposures" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0020871 ! abnormal locomotor response to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:17:11Z" xsd:dateTime

[Term]
id: MP:0020897
name: abnormal initiation of locomotor sensitization to cocaine
def: "any anomaly in the expected increase in locomotor activation after second exposure to cocaine" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0020896 ! abnormal locomotor sensitization to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:18:10Z" xsd:dateTime

[Term]
id: MP:0020898
name: abnormal expression of locomotor sensitization to cocaine
def: "any anomaly in the maintenance of locomotor sensitization to cocaine after a period of no exposure" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0020896 ! abnormal locomotor sensitization to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:19:28Z" xsd:dateTime

[Term]
id: MP:0020899
name: abnormal cocaine conditioned locomotor activation
def: "any anomaly in the locomotor response to a cocaine-paired environment in the absence of the cocaine" [https://orcid.org/0000-0001-7345-444X]
is_a: MP:0002062 ! abnormal associative learning
is_a: MP:0020871 ! abnormal locomotor response to cocaine
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-02T15:21:02Z" xsd:dateTime

[Term]
id: MP:0020900
name: abnormal middle ear epithelium morphology
def: "any structural anomaly of the epithelial layer of the middle ear" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000049 ! abnormal middle ear morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-08T14:48:00Z" xsd:dateTime

[Term]
id: MP:0020901
name: abnormal middle ear goblet cell morphology
def: "any structural anomaly of the mucin secreting cells located in the middle ear epithelium" [CL:0000160, PMID:27959908]
is_a: MP:0000358 ! abnormal cell morphology
is_a: MP:0020900 ! abnormal middle ear epithelium morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-08T14:51:28Z" xsd:dateTime

[Term]
id: MP:0020902
name: abnormal middle ear goblet cell number
def: "any anomaly in the number of goblet cells in the middle ear epithelium" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020901 ! abnormal middle ear goblet cell morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-08T14:59:09Z" xsd:dateTime

[Term]
id: MP:0020903
name: increased middle ear goblet cell number
def: "greater than the expected number of goblet cells in the middle ear epithelium" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020902 ! abnormal middle ear goblet cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-08T15:02:25Z" xsd:dateTime

[Term]
id: MP:0020904
name: decreased middle ear goblet cell number
def: "fewer than the expected number of goblet cells in the middle ear epithelium" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020902 ! abnormal middle ear goblet cell number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2019-10-08T15:02:43Z" xsd:dateTime

[Term]
id: MP:0020905
name: abnormal cocaine self-administration
def: "any anomaly in the volitional intake of cocaine" [JAX:CheslerLab]
is_a: MP:0002556 ! abnormal cocaine consumption
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:24:55Z" xsd:dateTime

[Term]
id: MP:0020906
name: abnormal acquisiton of operant behavior for a cocaine reinforcer
def: "any anomaly in the expression of a behavior associated with obtaining cocaine" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:30:32Z" xsd:dateTime

[Term]
id: MP:0020907
name: abnormal extinction of cocaine self-administration
def: "any anomaly in the reduction of cocaine seeking behavior in the absence of cocaine following acquisition of a learned response for cocaine" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:32:38Z" xsd:dateTime

[Term]
id: MP:0020908
name: abnormal reinstatement of an extinguished operant behavior for a cocaine reinforcer
def: "any anomaly in the restoration of extinguished cocaine seeking behavior" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:35:03Z" xsd:dateTime

[Term]
id: MP:0020909
name: abnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer
def: "any anomaly in the restoration of extinguished cocaine seeking behavior in response to cocaine associated cues" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:36:54Z" xsd:dateTime

[Term]
id: MP:0020910
name: abnormal stress-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer
def: "any anomaly in the restoration of extinguished cocaine seeking behavior in response to stress associated cues" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:38:59Z" xsd:dateTime

[Term]
id: MP:0020911
name: abnormal drug-induced reinstatement of an extinguished operant behavior for a drug reinforcer
def: "any anomaly in the restoration of extinguished cocaine seeking behavior in response to a drug" [JAX:CheslerLab]
is_a: MP:0020905 ! abnormal cocaine self-administration
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-03-23T15:40:59Z" xsd:dateTime

[Term]
id: MP:0020912
name: abnormal susceptibility to Riboviria infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with an RNA virus or viroid or from components of or toxins produced by a an RNA virus or viroid" [NCBITaxon:2559587, url:https\://www.sciencedirect.com/science/article/pii/B9780128096338212314]
synonym: "altered susceptibility to Riboviria infection" EXACT []
synonym: "altered susceptibility to RNA viroid infection" EXACT []
synonym: "altered susceptibility to RNA virus infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020913
name: increased susceptibility to Riboviria infection
def: "increase in the likelihood that an organism will develop ill effects from infection with an RNA virus or viroid or from components of or toxins produced by a an RNA virus or viroid" [url:https\://www.sciencedirect.com/science/article/pii/B9780128096338212314]
synonym: "increased susceptibility to RNA viroid infection" EXACT []
synonym: "increased susceptibility to RNA virus infection" EXACT []
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020914
name: decreased susceptibility to Riboviria infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with an RNA virus or viroid or from components of or toxins produced by a an RNA virus or viroid" [url:https\://www.sciencedirect.com/science/article/pii/B9780128096338212314]
synonym: "decreased susceptibility to RNA viroid infection" EXACT []
synonym: "decreased susceptibility to RNA virus infection" EXACT []
synonym: "resistance to Riboviria infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020915
name: abnormal susceptibility to Herpesvirales infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a linear, double-stranded DNA virus contained within a T=16 icosahedral capsid surrounded by a proteinaceous matrix (tegument) and then by a lipid envelope containing membrane-associated proteins  or from components of or toxins produced by a virus from this Order" [NCBITaxon:548681, PMID:19066710]
synonym: "altered susceptibility to Herpesvirales infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020916
name: increased susceptibility to Herpesvirales infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Herpesvirales virus or from components of or toxins produced by a Herpesvirales virus" [PMID:19066710]
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020915 ! abnormal susceptibility to Herpesvirales infection

[Term]
id: MP:0020917
name: decreased susceptibility to Herpesvirales infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Herpesvirales virus or from components of or toxins produced by a Herpesvirales virus" [PMID:19066710]
synonym: "resistance to Herpesvirales viral infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020915 ! abnormal susceptibility to Herpesvirales infection

[Term]
id: MP:0020918
name: abnormal susceptibility to Ortervirales infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a reverse-transcribing virus (defined by expression of a viral reverse transcriptases) or from components of or toxins produced by a virus from this Order" [NCBITaxon:2169561, PMID:29618642]
synonym: "altered susceptibility to Ortervirales infection" EXACT []
synonym: "altered susceptibility to reverse transcribing viral infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020919
name: increased susceptibility to Ortervirales infection
def: "increase in the likelihood that an organism will develop ill effects from infection with an Ortervirales virus or from components of or toxins produced by a virus from this Order" [PMID:29618642]
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020918 ! abnormal susceptibility to Ortervirales infection

[Term]
id: MP:0020920
name: decreased susceptibility to Ortervirales infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with an Ortervirales virus or from components of or toxins produced by a virus from this Order" [PMID:29618642]
synonym: "resistance to Ortervirales viral infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020918 ! abnormal susceptibility to Ortervirales infection

[Term]
id: MP:0020921
name: abnormal susceptibility to Parvoviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a non-enveloped, T=1 icosahedral capsid, linear, single-stranded DNA virus or from components of or toxins produced by a virus from this Family" [NCBITaxon:10780, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/ssdna-viruses/w/parvoviridae]
synonym: "altered susceptibility to Parvovirial infection" EXACT []
synonym: "altered susceptibility to Parvoviridae infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020922
name: increased susceptibility to Parvoviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Parvoviridae virus or from components of or toxins produced by a virus from this Family" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/ssdna-viruses/w/parvoviridae]
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020921 ! abnormal susceptibility to Parvoviridae infection

[Term]
id: MP:0020923
name: decreased susceptibility to Parvoviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Parvoviridae virus or from components of or toxins produced by a virus from this Family" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/ssdna-viruses/w/parvoviridae]
synonym: "resistance to Parvoviridae viral infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020921 ! abnormal susceptibility to Parvoviridae infection

[Term]
id: MP:0020924
name: abnormal susceptibility to Hepadnaviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a reverse-transcribing virs with a spherical, occasionally pleomorphic shape, a 42-50 nm diameter, and no evident surface projections after negative staining virus or from components of or toxins produced by a virus from this Family" [NCBITaxon:10404, url:https\://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/hepadnaviridae]
synonym: "altered susceptibility to Hepadnaviridae infection" EXACT []
is_a: MP:0020918 ! abnormal susceptibility to Ortervirales infection

[Term]
id: MP:0020925
name: increased susceptibility to Hepadnaviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Hepadnaviridae virus or from components of or toxins produced by a Hepadnaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/hepadnaviridae]
is_a: MP:0020919 ! increased susceptibility to Ortervirales infection
is_a: MP:0020924 ! abnormal susceptibility to Hepadnaviridae infection

[Term]
id: MP:0020926
name: decreased susceptibility to Hepadnaviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Hepadnaviridae virus or from components of or toxins produced by a Hepadnaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/hepadnaviridae]
synonym: "resistance to Hepadnaviridae viral infection" EXACT []
is_a: MP:0020920 ! decreased susceptibility to Ortervirales infection
is_a: MP:0020924 ! abnormal susceptibility to Hepadnaviridae infection

[Term]
id: MP:0020927
name: abnormal susceptibility to Poxviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a single strand DNA virus that replicate entirely in the cytoplasm or from components of or toxins produced by a virus from this Family" [NCBITaxon:10240, PMID:29145493]
synonym: "altered susceptibility to Poxviridae infection" EXACT []
synonym: "altered susceptibility to poxyvirus infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020928
name: increased susceptibility to Poxviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Poxviridae virus or from components of or toxins produced by a Poxviridae virus" [PMID:29145493]
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020927 ! abnormal susceptibility to Poxviridae infection

[Term]
id: MP:0020929
name: decreased susceptibility to Poxviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Poxviridae virus or from components of or toxins produced by a Poxviridae virus" [PMID:29145493]
synonym: "resistance to Poxviridae viral infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020927 ! abnormal susceptibility to Poxviridae infection

[Term]
id: MP:0020930
name: abnormal susceptibility to Adenoviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with a nonenveloped double stranded DNA virus of 70-90 nm in diameter, with an icosahedral capsid consisting of 240 nonvertex capsomers and 12 vertex capsomers virus or from components of or toxins produced by a virus from this Family" [NCBITaxon:10508, url:https\://www.sciencedirect.com/topics/neuroscience/adenoviridae]
synonym: "altered susceptibility to Adenovirial infection" EXACT []
synonym: "altered susceptibility to Adenoviridae infection" EXACT []
is_a: MP:0020185 ! abnormal susceptibility to viral infection

[Term]
id: MP:0020931
name: increased susceptibility to Adenoviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with an Adenoviridae virus or from components of or toxins produced by a Adenoviridae virus" [url:https\://www.sciencedirect.com/topics/neuroscience/adenoviridae]
is_a: MP:0002418 ! increased susceptibility to viral infection
is_a: MP:0020930 ! abnormal susceptibility to Adenoviridae infection

[Term]
id: MP:0020932
name: decreased susceptibility to Adenoviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with an Adenoviridae virus or from components of or toxins produced by a Adenoviridae virus" [url:https\://www.sciencedirect.com/topics/neuroscience/adenoviridae]
synonym: "resistance to Adenoviridae viral infection" EXACT []
is_a: MP:0002410 ! decreased susceptibility to viral infection
is_a: MP:0020930 ! abnormal susceptibility to Adenoviridae infection

[Term]
id: MP:0020933
name: abnormal susceptibility to Retroviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with an enveloped (about 100 nm in diameter), icosahedral reverse-transcribing virus that possess an RNA of about 7-10 kb or from components of or toxins produced by a virus from this Family" [NCBITaxon:11632, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/retrovirus]
synonym: "altered susceptibility to retroviral infection" EXACT []
synonym: "altered susceptibility to Retroviridae infection" EXACT []
is_a: MP:0020918 ! abnormal susceptibility to Ortervirales infection

[Term]
id: MP:0020934
name: increased susceptibility to Retroviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Retroviridae virus or from components of or toxins produced by a Retroviridae virus" [url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/retrovirus]
is_a: MP:0020919 ! increased susceptibility to Ortervirales infection
is_a: MP:0020933 ! abnormal susceptibility to Retroviridae infection

[Term]
id: MP:0020935
name: decreased susceptibility to Retroviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Retroviridae virus or from components of or toxins produced by a Retroviridae virus" [url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/retrovirus]
synonym: "resistance to Retroviridae viral infection" EXACT []
is_a: MP:0020920 ! decreased susceptibility to Ortervirales infection
is_a: MP:0020933 ! abnormal susceptibility to Retroviridae infection

[Term]
id: MP:0020936
name: abnormal susceptibility to Picornaviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the small, icosahedral viruses with a single-stranded, highly diverse positive-sense, non-segemented RNA genomes or from components of or toxins produced by a virus from this Family" [NCBITaxon:12058, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae]
synonym: "altered susceptibility to Picornaviridae infection" EXACT []
synonym: "altered susceptibility to picornavirus infection" EXACT []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020937
name: increased susceptibility to Picornaviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Picornaviridae virus or from components of or toxins produced by a Picornaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020936 ! abnormal susceptibility to Picornaviridae infection

[Term]
id: MP:0020938
name: decreased susceptibility to Picornaviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Picornaviridae virus or from components of or toxins produced by a Picornaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae]
synonym: "resistance to picornavirus viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020936 ! abnormal susceptibility to Picornaviridae infection

[Term]
id: MP:0020939
name: abnormal susceptibility to Togaviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the small, enveloped viruses with single-stranded, positive-sense, non-segmented RNA genomes of 10-12 kb or from components of or toxins produced by a virus from this Family" [NCBITaxon:11018, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/togaviridae]
synonym: "altered susceptibility to Togaviridae infection" EXACT []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020940
name: increased susceptibility to Togaviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Togaviridae virus or from components of or toxins produced by a Togaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/togaviridae]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020939 ! abnormal susceptibility to Togaviridae infection

[Term]
id: MP:0020941
name: decreased susceptibility to Togaviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Togaviridae virus or from components of or toxins produced by a Togaviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/togaviridae]
synonym: "resistance to Togaviridae viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020939 ! abnormal susceptibility to Togaviridae infection

[Term]
id: MP:0020942
name: abnormal susceptibility to Flaviviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the small enveloped viruses with positive-sense, non-segmented RNA genomes of approximately 9.0-13 kb or from components of or toxins produced by a virus from this Family" [NCBITaxon:11050, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae]
synonym: "altered susceptibility to Flaviviridae infection" EXACT []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020943
name: increased susceptibility to Flaviviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Flaviviridae virus or from components of or toxins produced by a Flaviviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020942 ! abnormal susceptibility to Flaviviridae infection

[Term]
id: MP:0020944
name: decreased susceptibility to Flaviviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Flaviviridae virus or from components of or toxins produced by a Flaviviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae]
synonym: "resistance to Flaviviridae viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020942 ! abnormal susceptibility to Flaviviridae infection

[Term]
id: MP:0020945
name: abnormal susceptibility to Orthomyxoviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the viruses whose genomes are composed of several (six to eight) segments of single-stranded RNA or from components of or toxins produced by a virus from this Family" [NCBITaxon:11308, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/orthomyxoviridae]
synonym: "altered susceptibility to Orthomyxoviridae infection" EXACT []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020946
name: increased susceptibility to Orthomyxoviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Orthomyxoviridae virus or from components of or toxins produced by a Orthomyxoviridae virus" [url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/orthomyxoviridae]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020945 ! abnormal susceptibility to Orthomyxoviridae infection

[Term]
id: MP:0020947
name: decreased susceptibility to Orthomyxoviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Orthomyxoviridae virus or from components of or toxins produced by a Orthomyxoviridae virus" [url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/orthomyxoviridae]
synonym: "resistance to Orthomyxoviridae viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020945 ! abnormal susceptibility to Orthomyxoviridae infection

[Term]
id: MP:0020948
name: abnormal susceptibility to Coronaviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the enveloped positive-sense single-stranded RNA viruses with a genome of up to 32kb in length or from components of or toxins produced by a virus from this Family" [NCBITaxon:11118, PMID:30568804, PMID:6654644]
synonym: "altered susceptibility to Coronaviridae infection" EXACT []
synonym: "altered susceptibility to coronavirus infection" NARROW []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020949
name: increased susceptibility to Coronaviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Coronaviridae virus or from components of or toxins produced by a Coronaviridae virus" [PMID:30568804, PMID:6654644]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020948 ! abnormal susceptibility to Coronaviridae infection

[Term]
id: MP:0020950
name: decreased susceptibility to Coronaviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Coronaviridae virus or from components of or toxins produced by a Coronaviridae virus" [PMID:30568804, PMID:6654644]
synonym: "resistance to Coronaviridae viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020948 ! abnormal susceptibility to Coronaviridae infection

[Term]
id: MP:0020951
name: abnormal susceptibility to Paramyxoviridae infection
def: "any anomaly in the likelihood that an organism will develop ill effects from infection with one of the large enveloped, negative-sense, single-stranded RNA viruses or from components of or toxins produced by a virus from this Family" [NCBITaxon:11158, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/mononegavirales/w/paramyxoviridae]
synonym: "altered susceptibility to Paramyxoviridae infection" EXACT []
is_a: MP:0020912 ! abnormal susceptibility to Riboviria infection

[Term]
id: MP:0020952
name: increased susceptibility to Paramyxoviridae infection
def: "increase in the likelihood that an organism will develop ill effects from infection with a Paramyxoviridae virus or from components of or toxins produced by a Paramyxoviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/mononegavirales/w/paramyxoviridae]
is_a: MP:0020913 ! increased susceptibility to Riboviria infection
is_a: MP:0020951 ! abnormal susceptibility to Paramyxoviridae infection

[Term]
id: MP:0020953
name: decreased susceptibility to Paramyxoviridae infection
def: "decrease in the likelihood that an organism will develop ill effects from infection with a Paramyxoviridae virus or from components of or toxins produced by a Paramyxoviridae virus" [url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/mononegavirales/w/paramyxoviridae]
synonym: "resistance to Paramyxoviridae viral infection" EXACT []
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection
is_a: MP:0020951 ! abnormal susceptibility to Paramyxoviridae infection

[Term]
id: MP:0020954
name: decreased mechanical nociceptive threshold
def: "a lower than average point at which mechanical pain sensation is first detectable" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyperresponsive mechanical nociception" EXACT []
synonym: "mechanical hyperalgesia" EXACT []
synonym: "reduced mechanical nociceptive threshold" EXACT []
is_a: MP:0002734 ! abnormal mechanical nociception
is_a: MP:0005407 ! hyperalgesia
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-05-04T14:44:55Z" xsd:dateTime

[Term]
id: MP:0020955
name: increased mechanical nociceptive threshold
def: "a higher than average point at which mechanical pain sensation is first detectable" [https://orcid.org/0000-0003-4606-0597]
synonym: "hyporesponsive mechanical nociception" EXACT []
synonym: "mechanical hypoalgesia" EXACT []
is_a: MP:0002734 ! abnormal mechanical nociception
is_a: MP:0003043 ! hypoalgesia
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-05-04T14:45:08Z" xsd:dateTime

[Term]
id: MP:0020956
name: absent mechanical nociception
def: "inability to sense mechanical pain" [https://orcid.org/0000-0003-4606-0597]
synonym: "unresponsive to mechanical nociception" EXACT []
is_a: MP:0002734 ! abnormal mechanical nociception
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-05-04T14:45:25Z" xsd:dateTime

[Term]
id: MP:0020957
name: abnormal meiotic drive
def: "any anomaly in the process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes" [GO:0110134]
is_a: MP:0001930 ! abnormal meiosis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2020-09-04T14:08:51Z" xsd:dateTime

[Term]
id: MP:0020958
name: abnormal c-wave implicit time
def: "anomaly in the time from the onset of light stimulus to the peak of the c-wave" [http://webvision.med.utah.edu, KOMP:abby-jones]
is_a: MP:0012033 ! abnormal ERG implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T15:41:03Z" xsd:dateTime

[Term]
id: MP:0020959
name: decreased c-wave implicit time
def: "decrease in the time from the onset of light stimulus to the peak of the c-wave" [https://orcid.org/0000-0003-4606-0597, https://webvision.med.utah.edu/]
synonym: "faster c-wave implicit time" EXACT []
is_a: MP:0020958 ! abnormal c-wave implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T15:46:41Z" xsd:dateTime

[Term]
id: MP:0020960
name: increased c-wave implicit time
def: "increase in the time from the onset of light stimulus to the peak of the c-wave" [https://orcid.org/0000-0003-4606-0597, https://webvision.med.utah.edu/]
synonym: "delayed c-wave implicit time" EXACT []
synonym: "prolonged c-wave implicit time" EXACT []
is_a: MP:0020958 ! abnormal c-wave implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T15:49:49Z" xsd:dateTime

[Term]
id: MP:0020961
name: abnormal c-wave amplitude
def: "anomaly in the size (height or maximum displacement) of the c-wave as measured in the electroretinogram" [KOMP:abby-jones]
is_a: MP:0012040 ! abnormal c-wave shape
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T19:36:48Z" xsd:dateTime

[Term]
id: MP:0020962
name: increased c-wave amplitude
def: "increase in the size (height or maximum displacement) of the c-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020961 ! abnormal c-wave amplitude
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T19:37:19Z" xsd:dateTime

[Term]
id: MP:0020963
name: decreased c-wave amplitude
def: "reduction in the size (height or maximum displacement) of the c-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-4606-0597]
synonym: "attenuated c-wave amplitude" EXACT []
synonym: "reduced c-wave amplitude" EXACT []
is_a: MP:0020961 ! abnormal c-wave amplitude
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T19:37:37Z" xsd:dateTime

[Term]
id: MP:0020964
name: abnormal platelet dense granule secretion
def: "any anomaly in the regulated release of any of the contents of platelet dense granules, such as cations (Ca2+, Mg2+, K+), polyphosphates, nucleotides (ADP, ATP, GTP) or bioactive amines (serotonin and histamine)" [PMID:25879272, PMID:25999457]
synonym: "abnormal platelet dense granule exocytosis" EXACT []
is_a: MP:0009446 ! abnormal platelet dense granule physiology
is_a: MP:0020848 ! abnormal exocytosis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T20:48:13Z" xsd:dateTime

[Term]
id: MP:0020965
name: increased platelet dense granule secretion
def: "increase in the regulated release of any of the contents of platelet dense granules, such as cations (Ca2+, Mg2+, K+), polyphosphates, nucleotides (ADP, ATP, GTP) or bioactive amines (serotonin and histamine)" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated platelet dense granule secretion" EXACT []
is_a: MP:0020964 ! abnormal platelet dense granule secretion
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T20:52:12Z" xsd:dateTime

[Term]
id: MP:0020966
name: decreased platelet dense granule secretion
def: "decrease in the regulated release of any of the contents of platelet dense granules, such as cations (Ca2+, Mg2+, K+), polyphosphates, nucleotides (ADP, ATP, GTP) or bioactive amines (serotonin and histamine)" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased platelet dense granule exocytosis" EXACT []
synonym: "reduced platelet dense granule secretion" EXACT []
is_a: MP:0020964 ! abnormal platelet dense granule secretion
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-07T20:52:34Z" xsd:dateTime

[Term]
id: MP:0020967
name: absent platelet dense granule secretion
def: "absence of the regulated release of any of the contents of platelet dense granules, such as cations (Ca2+, Mg2+, K+), polyphosphates, nucleotides (ADP, ATP, GTP) or bioactive amines (serotonin and histamine)" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020966 ! decreased platelet dense granule secretion
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T15:35:22Z" xsd:dateTime

[Term]
id: MP:0020968
name: enhanced conditioned taste aversion behavior
def: "increase in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness" [https://orcid.org/0000-0001-5356-4174, PMID:11958542]
synonym: "enhanced conditioned taste aversion behaviour" EXACT []
synonym: "increased conditioned taste aversion behavior" EXACT []
is_a: MP:0002805 ! abnormal conditioned taste aversion behavior
is_a: MP:0012313 ! enhanced avoidance learning behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T15:39:53Z" xsd:dateTime

[Term]
id: MP:0020969
name: impaired conditioned taste aversion behavior
def: "decrease in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness" [https://orcid.org/0000-0001-5356-4174, PMID:11958542]
synonym: "decreased conditioned taste aversion behavior" EXACT []
synonym: "impaired conditioned taste aversion behaviour" EXACT []
synonym: "reduced conditioned taste aversion behavior" EXACT []
is_a: MP:0002805 ! abnormal conditioned taste aversion behavior
is_a: MP:0012312 ! impaired avoidance learning behavior
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T15:40:15Z" xsd:dateTime

[Term]
id: MP:0020970
name: abnormal neurotransmitter turnover
def: "any anomaly in the process by which neurotransmitters are renewed, frequently measured as a ratio of metabolite(s) of the neurotransmitter to the neurotransmitter itself" [https://link.springer.com/chapter/10.1007/978-1-4615-9778-0_1, https://pubmed.ncbi.nlm.nih.gov/19873346/, PMID:30759250]
is_a: MP:0005266 ! abnormal metabolism
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-01-08T18:43:12Z" xsd:dateTime

[Term]
id: MP:0020971
name: increased neurotransmitter turnover
def: "increase in the process by which neurotransmitters are renewed, frequently measured as a ratio of metabolite(s) of the neurotransmitter to the neurotransmitter itself" [https://pubmed.ncbi.nlm.nih.gov/19873346/, PMID:30759250]
synonym: "elevated neurotransmitter turnover" EXACT []
is_a: MP:0020970 ! abnormal neurotransmitter turnover
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-01-08T18:45:36Z" xsd:dateTime

[Term]
id: MP:0020972
name: decreased neurotransmitter turnover
def: "reduction in the process by which neurotransmitters are renewed, frequently measured as a ratio of metabolite(s) of the neurotransmitter to the neurotransmitter itself" [https://pubmed.ncbi.nlm.nih.gov/19873346/, PMID:30759250]
synonym: "impaired neurotransmitter turnover" EXACT []
synonym: "reduced neurotransmitter turnover" EXACT []
is_a: MP:0020970 ! abnormal neurotransmitter turnover
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-01-08T18:45:54Z" xsd:dateTime

[Term]
id: MP:0020973
name: abnormal gland development
def: "any anomaly in the process whose specific outcome is the progression of a gland over time, from its formation to the mature structure" [GO:0048732]
is_a: MP:0002163 ! abnormal gland morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T19:30:55Z" xsd:dateTime

[Term]
id: MP:0020974
name: abnormal FO-wave shape
def: "any anomaly in the graphical representation of the FO-wave in the electroretinogram; the ERG FO-wave can be used to assess the functional integrity of the photoreceptors, the pigment epithelial cells and the interactions between them" [KOMP:abby-jones, PMID:30040236]
synonym: "abnormal fast oscillation wave shape" EXACT []
is_a: MP:0012029 ! abnormal electroretinogram waveform feature
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:06:07Z" xsd:dateTime

[Term]
id: MP:0020975
name: abnormal FO-wave amplitude
def: "anomaly in the size (height or maximum displacement) of the FO-wave as measured in the electroretinogram" [KOMP:abby-jones, PMID:30040236]
synonym: "abnormal fast oscillation wave amplitude" EXACT []
is_a: MP:0020974 ! abnormal FO-wave shape
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:09:23Z" xsd:dateTime

[Term]
id: MP:0020976
name: increased FO-wave amplitude
def: "increase in the size (height or maximum displacement) of the FO-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased fast oscillation wave amplitude" EXACT []
is_a: MP:0020975 ! abnormal FO-wave amplitude
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:12:40Z" xsd:dateTime

[Term]
id: MP:0020977
name: decreased FO-wave amplitude
def: "decrease in the size (height or maximum displacement) of the FO-wave as measured in the electroretinogram" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased fast oscillation wave amplitude" EXACT []
synonym: "reduced FO-wave ampltude" EXACT []
is_a: MP:0020975 ! abnormal FO-wave amplitude
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:12:52Z" xsd:dateTime

[Term]
id: MP:0020978
name: abnormal FO-wave implicit time
def: "anomaly in the time from the onset of light stimulus to the peak of the FO-wave" [KOMP:abby-jones, PMID:30040236]
synonym: "abnormal fast oscillation wave implicit time" EXACT []
is_a: MP:0012033 ! abnormal ERG implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:17:14Z" xsd:dateTime

[Term]
id: MP:0020979
name: decreased FO-wave implicit time
def: "decrease in the time from the onset of light stimulus to the peak of the FO-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "faster FO-wave implicit time" EXACT []
is_a: MP:0020978 ! abnormal FO-wave implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:32:04Z" xsd:dateTime

[Term]
id: MP:0020980
name: increased FO-wave implicit time
def: "increase in the time from the onset of light stimulus to the peak of the FO-wave" [https://orcid.org/0000-0003-4606-0597]
synonym: "delayed FO-wave implicit time" EXACT []
synonym: "prolonged FO-wave implicit time" EXACT []
is_a: MP:0020978 ! abnormal FO-wave implicit time
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T20:32:20Z" xsd:dateTime

[Term]
id: MP:0020981
name: abnormal immune system development
def: "any anomaly in the process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure" [GO:0002520]
is_a: MP:0000685 ! abnormal immune system morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T21:01:54Z" xsd:dateTime

[Term]
id: MP:0020982
name: abnormal skin adnexa development
def: "any anomaly in the process whose specific outcome is the progression of the tissues or structures associated with or embedded in the skin over time, from formation to the mature structure" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal skin accessory structure development" EXACT []
is_a: MP:0010678 ! abnormal skin adnexa morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-08T21:13:42Z" xsd:dateTime

[Term]
id: MP:0020983
name: abnormal circulating factor XI level
def: "any anomaly in the concentration in the blood of factor XI, also known as plasma thromboplastin antecedent, one of the serine proteases of the coagulation cascade" [https://orcid.org/0000-0001-5356-4174] {def="PMID:1169825"}
is_a: MP:0001570 ! abnormal circulating enzyme level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-11T20:34:23Z" xsd:dateTime

[Term]
id: MP:0020984
name: decreased circulating factor XI level
def: "decrease in the concentration in the blood of factor XI, also known as plasma thromboplastin antecedent, one of the serine proteases of the coagulation cascade" [https://orcid.org/0000-0001-5356-4174, PMID:1169825]
synonym: "reduced circulating factor XI level" EXACT []
is_a: MP:0014451 ! decreased circulating enzyme level
is_a: MP:0020983 ! abnormal circulating factor XI level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-11T20:39:01Z" xsd:dateTime

[Term]
id: MP:0020985
name: increased circulating factor XI level
def: "increase in the concentration in the blood of factor XI, also known as plasma thromboplastin antecedent, one of the serine proteases of the coagulation cascade" [https://orcid.org/0000-0001-5356-4174, PMID:1169825]
synonym: "elevated circulating factor XI level" EXACT []
is_a: MP:0014450 ! increased circulating enzyme level
is_a: MP:0020983 ! abnormal circulating factor XI level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-11T20:39:11Z" xsd:dateTime

[Term]
id: MP:0020986
name: abnormal circulating ceruloplasmin level
def: "any anomaly in the concentration in the blood of ceruloplasmin, a ferroxidase enzyme that contains copper atoms in its structure and is the major carrier of copper in the blood" [https://en.wikipedia.org/wiki/Ceruloplasmin]
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0012611 ! abnormal ceruloplasmin level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-11T21:28:02Z" xsd:dateTime

[Term]
id: MP:0020987
name: abnormal urine lipocalin 2 level
def: "any anomaly in the amount in the urine of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "abnormal urine LCN2 level" EXACT []
synonym: "abnormal urine neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "abnormal urine NGAL level" EXACT []
is_a: MP:0006315 ! abnormal urine protein level
is_a: MP:0031337 ! abnormal lipocalin 2 level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:06:08Z" xsd:dateTime

[Term]
id: MP:0020988
name: decreased urine lipocalin 2 level
def: "reduction in the amount in the urine of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "decreased urine neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "decreased urine NGAL level" EXACT []
synonym: "reduced urine LCN2 level" EXACT []
synonym: "reduced urine lipocalin 2 level" EXACT []
is_a: MP:0020987 ! abnormal urine lipocalin 2 level
is_a: MP:0031338 ! decreased lipocalin 2 level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:11:07Z" xsd:dateTime

[Term]
id: MP:0020989
name: increased urine lipocalin 2 level
def: "increase in the amount in the urine of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "increased urine LCN2 level" EXACT []
synonym: "increased urine neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "increased urine NGAL level" EXACT []
is_a: MP:0020987 ! abnormal urine lipocalin 2 level
is_a: MP:0031339 ! increased lipocalin 2 level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:11:16Z" xsd:dateTime

[Term]
id: MP:0020990
name: abnormal urine HAVCR1 level
def: "any anomaly in the amount in the urine of HAVCR1, a membrane receptor for both human hepatitis A virus (HHAV) and Timd4 that is frequently upregulated in response to kidney injury" [https://en.wikipedia.org/wiki/HAVCR1, https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "abnormal urine KIM1 level" EXACT []
is_a: MP:0006315 ! abnormal urine protein level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:23:52Z" xsd:dateTime

[Term]
id: MP:0020991
name: decreased urine HAVCR1 level
def: "reduction in the amount in the urine of HAVCR1, a membrane receptor for both human hepatitis A virus (HHAV) and Timd4 that is frequently upregulated in response to kidney injury" [https://en.wikipedia.org/wiki/HAVCR1, https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "decreased urine KIM1 level" EXACT []
synonym: "reduced urine KIM1 level" EXACT []
is_a: MP:0020990 ! abnormal urine HAVCR1 level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:28:30Z" xsd:dateTime

[Term]
id: MP:0020992
name: increased urine HAVCR1 level
def: "increase in the amount in the urine of HAVCR1, a membrane receptor for both human hepatitis A virus (HHAV) and Timd4 that is frequently upregulated in response to kidney injury" [https://en.wikipedia.org/wiki/HAVCR1, https://orcid.org/0000-0002-9553-7227, PMID:29437896]
synonym: "increased urine KIM1 level" EXACT []
is_a: MP:0020990 ! abnormal urine HAVCR1 level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:29:23Z" xsd:dateTime

[Term]
id: MP:0020993
name: abnormal urine cytokine level
def: "any anomaly in the amount in the urine of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7]
is_a: MP:0006315 ! abnormal urine protein level
is_a: MP:0008713 ! abnormal cytokine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:55:07Z" xsd:dateTime

[Term]
id: MP:0020994
name: abnormal urine osteopontin level
def: "any anomaly in the amount in the urine of osteopontin, a proinflammatory cytokine that upregulates expression of interferon-gamma and interleukin-12 and is a key factor in tissue repair after injury" [https://orcid.org/0000-0002-9553-7227, PMID:28698867, PMID:29437896]
synonym: "abnormal urine OPN level" EXACT []
synonym: "abnormal urine OSP level" EXACT []
synonym: "abnormal urine SPP1 level" EXACT []
is_a: MP:0020993 ! abnormal urine cytokine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T19:58:59Z" xsd:dateTime

[Term]
id: MP:0020995
name: decreased urine osteopontin level
def: "reduction in the amount in the urine of osteopontin, a proinflammatory cytokine that upregulates expression of interferon-gamma and interleukin-12 and is a key factor in tissue repair after injury" [https://orcid.org/0000-0002-9553-7227, PMID:28698867, PMID:29437896]
synonym: "decreased urine OPN level" EXACT []
synonym: "decreased urine OSP level" EXACT []
synonym: "reduced urine osteopontin level" EXACT []
synonym: "reduced urine SPP1 level" EXACT []
is_a: MP:0014434 ! decreased cytokine level
is_a: MP:0020994 ! abnormal urine osteopontin level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T20:05:23Z" xsd:dateTime

[Term]
id: MP:0020996
name: increased urine osteopontin level
def: "increase in the amount in the urine of osteopontin, a proinflammatory cytokine that upregulates expression of interferon-gamma and interleukin-12 and is a key factor in tissue repair after injury" [https://orcid.org/0000-0002-9553-7227, PMID:28698867, PMID:29437896]
synonym: "increased urine OPN level" EXACT []
synonym: "increased urine OSP level" EXACT []
synonym: "increased urine SPP1 level" EXACT []
is_a: MP:0014433 ! increased cytokine level
is_a: MP:0020994 ! abnormal urine osteopontin level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-15T20:05:33Z" xsd:dateTime

[Term]
id: MP:0020997
name: abnormal subcutaneous adipose tissue amount
def: "anomaly in the quantity of adipose tissue beneath the skin" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0005452 ! abnormal adipose tissue amount
is_a: MP:0011156 ! abnormal hypodermis fat layer morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-26T16:45:37Z" xsd:dateTime

[Term]
id: MP:0020998
name: abnormal epididymal fat pad weight
def: "any anomaly in the weight of the encapsulated adipose tissue associated with the epididymis" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal epididymal fat depot weight" EXACT []
synonym: "abnormal periepididymal fat pad weight" EXACT []
is_a: MP:0006319 ! abnormal epididymal fat pad morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-26T17:10:26Z" xsd:dateTime

[Term]
id: MP:0020999
name: abnormal small intestine length
def: "any anomaly in the length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000496 ! abnormal small intestine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-26T17:30:37Z" xsd:dateTime

[Term]
id: MP:0021000
name: abnormal cecum weight
def: "any anomaly in the weight of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal caecum weight" EXACT []
is_a: MP:0000494 ! abnormal cecum morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-01-26T17:36:18Z" xsd:dateTime

[Term]
id: MP:0021001
name: impaired neuron physiology
def: "any anomaly resulting in reduced function of a neuron" [PMID:9130294]
synonym: "impaired neuronal physiology" EXACT []
synonym: "neuronal dysfunction" EXACT []
is_a: MP:0004811 ! abnormal neuron physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-19T19:30:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021002
name: brain lesion
def: "focal pathological changes characterized by alteration in the size, shape and organization of the cellular components of the brain tissue" [PMID:10867785]
synonym: "cerebral lesion" NARROW []
is_a: MP:0002152 ! abnormal brain morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-19T19:38:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021003
name: cerebral infarct
def: "a necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [PMID:10867785]
synonym: "brain infarct" BROAD []
synonym: "cerebrum infarct" EXACT []
is_a: MP:0008540 ! abnormal cerebral hemisphere morphology
is_a: MP:0021002 ! brain lesion
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-19T19:42:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021004
name: cerebral microinfarct
def: "an infarct found in the cerebrum that can only be observed microscopically" [PMID:10867785]
synonym: "brain microinfarct" BROAD []
synonym: "cerebrum microinfarct" EXACT []
is_a: MP:0021003 ! cerebral infarct
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T18:14:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021005
name: cerebral cortex microinfarct
def: "an infarct located on the outer layer of the cerebrum that can only be observed microscopically" [PMID:10867785]
synonym: "cortical microinfarct" EXACT []
is_a: MP:0000788 ! abnormal cerebral cortex morphology
is_a: MP:0021004 ! cerebral microinfarct
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T18:20:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021006
name: hippocampal microinfarct
def: "an infarct located in the hippocampus that can only be observed microscopically" [PMID:10867785]
is_a: MP:0000807 ! abnormal hippocampus morphology
is_a: MP:0021004 ! cerebral microinfarct
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T18:44:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021007
name: amygdala microinfarct
def: "an infarct located in the amygdala that can only be observed microscopically" [PMID:10867785]
is_a: MP:0000818 ! abnormal amygdala morphology
is_a: MP:0021002 ! brain lesion
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T18:55:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021008
name: temporal lobe atrophy
def: "acquired diminution of the size of the lower lateral part of the cerebral hemisphere" [PMID:9130294]
synonym: "atrophy of temporal lobe" EXACT []
is_a: MP:0000801 ! abnormal temporal lobe morphology
is_a: MP:0012508 ! forebrain atrophy
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T19:25:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021009
name: abnormal synaptic physiology
def: "any functional anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [PMID:30439458]
synonym: "abnormal synapse physiology" EXACT []
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T19:41:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021010
name: impaired synaptic physiology
def: "any functional impairment of a synapse" [PMID:30439458]
synonym: "impaired synapse function" EXACT []
synonym: "synaptic dysfunction" EXACT []
is_a: MP:0021009 ! abnormal synaptic physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T19:48:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021011
name: parietal cortex atrophy
def: "acquired diminution of the size of the upper central part of the cerebral hemisphere associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [PMID:18413473]
synonym: "atrophy of the parietal lobe" EXACT []
is_a: MP:0000794 ! abnormal parietal lobe morphology
is_a: MP:0012508 ! forebrain atrophy
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-20T20:32:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021012
name: decreased acetylcholine level
def: "less than the normal amount of acetylcholine" [PMID:12163621]
synonym: "decreased Ach level" EXACT []
synonym: "reduced Ach level" EXACT []
is_a: MP:0014455 ! decreased hormone level
is_a: MP:0030675 ! abnormal acetylcholine level
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-22T17:44:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021013
name: abnormal synaptic vesicle endocytosis
def: "any anomaly in the vesicle-mediated transport process in which neuronal cells form a new membrane-bounded vesicle by the invagination of a small region of the synaptic plasma membrane" [PMID:10072535]
is_a: MP:0021009 ! abnormal synaptic physiology
is_a: MP:0030951 ! abnormal endocytosis
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-22T17:54:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-4154-7358

[Term]
id: MP:0021014
name: abnormal tau protein phosphorylation
def: "any anomaly in the process by which a phosphate group is introduced to the tau protein" [PMID:23847585, PMID:28625569]
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-22T20:03:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021015
name: increased tau protein phosphorylation
def: "increase in the process by which a phosphate group is introduced to the tau protein" [PMID:23847585, PMID:28625569]
comment: accumulation of aggregates of hyperphosphorylated tau protein are associated with many neurodegenerative disease including Alzheimer Disease, progressive supranuclear palsy, and some types of frontotemporal dementia
synonym: "elevated tau protein phosphorylation" EXACT []
synonym: "hyperphosphorylated tau" RELATED []
is_a: MP:0021014 ! abnormal tau protein phosphorylation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-22T20:08:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021016
name: decreased tau protein phosphorylation
def: "decrease in the process by which a phosphate group is introduced to the tau protein" [PMID:23847585, PMID:28625569]
synonym: "reduced tau protein phosphorylation" EXACT []
is_a: MP:0021014 ! abnormal tau protein phosphorylation
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-22T20:13:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021017
name: abnormal dendritic spine number
def: "any anomaly in the number of spines on a dendrite" [PMID:8046469]
is_a: MP:0009936 ! abnormal dendritic spine morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-26T19:25:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021018
name: decreased dendritic spine number
def: "fewer than the expected number of spines on a given dendrite" [PMID:8046469]
synonym: "decreased dendrite branch number" EXACT []
synonym: "reduced dendritic spine number" EXACT []
is_a: MP:0021017 ! abnormal dendritic spine number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-26T19:28:15Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021019
name: increased dendritic spine number
def: "greater than the expected number of spines on a given dendrite" [PMID:8046469]
synonym: "elevated dendritic branch number" EXACT []
is_a: MP:0021017 ! abnormal dendritic spine number
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-26T19:32:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021020
name: neurite dystrophy
def: "degenerated neurite(s) that may be the end result of genetic abnormalities or inadequate or faulty metabolism" [PMID:30899091]
synonym: "dystrophic neurite" EXACT []
is_a: MP:0008415 ! abnormal neurite morphology
property_value: dc:creator https://orcid.org/0000-0003-4606-0597
property_value: dc:date "2021-07-26T19:48:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226

[Term]
id: MP:0021021
name: abnormal adipose tissue noradrenaline turnover
def: "any anomaly in the process by which noradrenaline is broken down and renewed in the adipose tissue" [] {comment="PMID:23555928"}
synonym: "abnormal adipose tissue norepinephrine turnover" EXACT []
is_a: MP:0005266 ! abnormal metabolism
is_a: MP:0005666 ! abnormal adipose tissue physiology
property_value: dc:date "2021-12-10T20:21:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-9196-0135
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021022
name: decreased adipose tissue noradrenaline turnover
def: "any reduction in the process by which noradrenaline is broken down and renewed in the adipose tissue" [PMID:23555928]
synonym: "decreased adipose tissue norepinephrine turnover" EXACT []
synonym: "reduced adipose tissue noradrenaline turnover" EXACT []
is_a: MP:0021021 ! abnormal adipose tissue noradrenaline turnover
property_value: dc:date "2021-12-10T20:35:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-9196-0135
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021023
name: increased adipose tissue noradrenaline turnover
def: "any increase in the process by which noradrenaline is broken down and renewed in the adipose tissue" [PMID:23555928]
synonym: "elevated adipose tissue noradrenaline turnover" EXACT []
synonym: "increased adipose tissue norepinephrine turnover" EXACT []
is_a: MP:0021021 ! abnormal adipose tissue noradrenaline turnover
property_value: dc:date "2021-12-10T20:35:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-9196-0135
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021024
name: abnormal cerebrospinal fluid physiology
def: "any functional anomaly of the fluid that the occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord and/or its suspended elements" [UBERON:0001359]
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: dc:date "2021-12-10T21:07:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021025
name: increased cerebrospinal fluid amyloid beta 40 isoform level
def: "increase in the amount of amyloid beta 40 found in cerebrospinal fluid" [PMID:19273758]
synonym: "elevated cerebrospinal fluid amyloid beta 40 isoform level" EXACT []
synonym: "increased cerebrospinal fluid Abeta 40 level" EXACT []
synonym: "increased cerebrospinal fluid beta amyloid 40 level" EXACT []
is_a: MP:0021027 ! abnormal cerebrospinal fluid amyloid beta 40 isoform level
is_a: MP:0021150 ! increased amyloid beta protein level
property_value: dc:date "2021-12-10T21:18:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021026
name: decreased cerebrospinal fluid amyloid beta 40 isoform level
def: "reduction in the amount of amyloid beta 40 found in cerebrospinal fluid" [PMID:19273758]
synonym: "decreased cerebrospinal fluid Abeta 40 level" EXACT []
synonym: "decreased cerebrospinal fluid beta amyloid 40 level" EXACT []
synonym: "reduced cerebrospinal fluid amyloid beta 40 isoform level" EXACT []
is_a: MP:0021027 ! abnormal cerebrospinal fluid amyloid beta 40 isoform level
is_a: MP:0021151 ! decreased amyloid beta protein level
property_value: dc:date "2021-12-10T21:18:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021027
name: abnormal cerebrospinal fluid amyloid beta 40 isoform level
def: "any anomaly in the amount of amyloid beta 40 found in cerebrospinal fluid" [PMID:19273758]
synonym: "abnormal cerebrospinal fluid Abeta 40 level" EXACT []
synonym: "abnormal cerebrospinal fluid beta amyloid 40 level" EXACT []
is_a: MP:0021024 ! abnormal cerebrospinal fluid physiology
is_a: MP:0021149 ! abnormal amyloid beta protein level
property_value: dc:date "2021-12-10T21:18:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021028
name: abnormal tumor necrosis factor (ligand) superfamily member 11 level
def: "anomaly in the amount of TNF superfamily member 11 protein" [PMID:20643942]
synonym: "abnormal OPGL level" EXACT []
synonym: "abnormal osteoprotegerin ligand level" EXACT []
synonym: "abnormal RANKL level" EXACT []
synonym: "abnormal receptor activator of nuclear factor kappa B ligand level" EXACT []
synonym: "abnormal Tnfsf11 level" EXACT []
is_a: MP:0008469 ! abnormal protein level
property_value: dc:date "2021-12-13T21:27:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021029
name: increased tumor necrosis factor (ligand) superfamily member 11 level
def: "increase in the amount of TNF superfamily member 11 protein" [PMID:20643942]
synonym: "elevated RANKL level" EXACT []
synonym: "increased OPGL level" EXACT []
synonym: "increased osteoprotegerin ligand level" EXACT []
synonym: "increased receptor activator of nuclear factor kappa B ligand level" EXACT []
synonym: "increased Tnfsf11 level" EXACT []
is_a: MP:0021028 ! abnormal tumor necrosis factor (ligand) superfamily member 11 level
property_value: dc:date "2021-12-13T21:34:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021030
name: decreased tumor necrosis factor (ligand) superfamily member 11 level
def: "decrease in the amount of TNF superfamily member 11 protein" [PMID:20643942]
synonym: "decreased osteoprotegerin ligand level" EXACT []
synonym: "decreased RANKL level" EXACT []
synonym: "decreased receptor activator of nuclear factor kappa B ligand level" EXACT []
synonym: "decreased Tnfsf11 level" EXACT []
synonym: "reduced OPGL level" EXACT []
is_a: MP:0021028 ! abnormal tumor necrosis factor (ligand) superfamily member 11 level
property_value: dc:date "2021-12-13T21:34:15Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021031
name: abnormal tumor necrosis factor receptor superfamily member 11b level
def: "anomaly in the amount of tumor necrosis factor receptor superfamily member 11b protein" [PMID:20643942]
synonym: "abnormal Opg level" EXACT []
synonym: "abnormal osteoprotegerin level" EXACT []
synonym: "abnormal Tnfrsf11b level" EXACT []
is_a: MP:0008469 ! abnormal protein level
property_value: dc:date "2021-12-14T19:11:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021032
name: increased tumor necrosis factor receptor superfamily member 11b level
def: "increase in the amount of tumor necrosis factor receptor superfamily member 11b protein" [PMID:20643942]
synonym: "elevated osteoprotegerin level" EXACT []
synonym: "increased Opg level" EXACT []
synonym: "increased Tnfrsf11b level" EXACT []
is_a: MP:0021031 ! abnormal tumor necrosis factor receptor superfamily member 11b level
property_value: dc:date "2021-12-14T19:12:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021033
name: decreased tumor necrosis factor receptor superfamily member 11b level
def: "decrease in the amount of tumor necrosis factor receptor superfamily member 11b protein" [PMID:20643942]
synonym: "decreased Opg level" EXACT []
synonym: "decreased Tnfrsf11b level" EXACT []
synonym: "reduced osteoprotegerin level" EXACT []
is_a: MP:0021031 ! abnormal tumor necrosis factor receptor superfamily member 11b level
property_value: dc:date "2021-12-14T19:12:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021034
name: abnormal circulating cartilage oligomeric matrix protein level
def: "any anomaly in the amount of cartilage oligomeric matrix protein, often used as a marker for cartilage turnover, in the blood, plasma, or serum" [PMID:31963737, PMID:8909256]
synonym: "abnormal circulating COMP level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:date "2021-12-14T19:44:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021035
name: decreased circulating cartilage oligomeric matrix protein level
def: "decrease in the amount of cartilage oligomeric matrix protein in the blood, plasma, or serum" [PMID:8909256]
synonym: "reduced circulating COMP level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0021034 ! abnormal circulating cartilage oligomeric matrix protein level
property_value: dc:date "2021-12-14T19:44:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021036
name: increased circulating cartilage oligomeric matrix protein level
def: "increase in the amount of cartilage oligomeric matrix protein in the blood, plasma, or serum" [PMID:8909256]
synonym: "elevated circulating COMP level" EXACT []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0021034 ! abnormal circulating cartilage oligomeric matrix protein level
property_value: dc:date "2021-12-14T19:44:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021037
name: abnormal circulating orosomucoid 1 protein level
def: "any anomaly in the amount of the acute phase protein orosomucoid 1 in the blood, serum, or plasma" [PMID:11058758]
synonym: "abnormal acute-phase protein alpha1-acid-glycoprotein level" EXACT []
synonym: "abnormal acute-phase reactant AGP level" EXACT []
synonym: "abnormal alpha1-acid-glycoprotein level" EXACT []
synonym: "abnormal ORM1 level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0010211 ! abnormal acute phase protein level
property_value: dc:date "2021-12-14T21:13:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021038
name: increased circulating orosomucoid 1 protein level
def: "increase in the amount of the acute phase protein orosomucoid 1 in the blood, serum, or plasma" [PMID:11058758]
synonym: "elevated acute-phase reactant AGP level" EXACT []
synonym: "increased acute-phase protein alpha1-acid-glycoprotein level" EXACT []
synonym: "increased alpha1-acid-glycoprotein level" EXACT []
synonym: "increased ORM1 level" EXACT []
is_a: MP:0014499 ! increased acute phase protein level
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0021037 ! abnormal circulating orosomucoid 1 protein level
property_value: dc:date "2021-12-14T21:14:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021039
name: decreased circulating orosomucoid 1 protein level
def: "decrease in the amount of the acute phase protein orosomucoid 1 in the blood, serum, or plasma" [PMID:11058758]
synonym: "decreased acute-phase reactant AGP level" EXACT []
synonym: "decreased alpha1-acid-glycoprotein level" EXACT []
synonym: "decreased ORM1 level" EXACT []
synonym: "reduced acute-phase protein alpha1-acid-glycoprotein level" EXACT []
is_a: MP:0014500 ! decreased acute phase protein level
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0021037 ! abnormal circulating orosomucoid 1 protein level
property_value: dc:date "2021-12-14T21:15:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021040
name: abnormal circulating LDL phospholipid level
def: "any anomaly in the amount of the complex of low density lipoproteins, small (18-25 nm) and low density (1.019-1.063 g/ml) particles, and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39026, PMID:8301098]
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0020127 ! abnormal circulating non-HDL phospholipid level
property_value: dc:date "2021-12-15T21:03:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021041
name: abnormal circulating VLDL phospholipid level
def: "any anomaly in the amount of the complex of very low density lipoproteins, large (30-80 nm) and very low density (0.93-1.006 g/ml) particles, and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39027, PMID:8301098]
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0020127 ! abnormal circulating non-HDL phospholipid level
property_value: dc:date "2021-12-15T21:03:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021042
name: increased circulating LDL phospholipid level
def: "increase in the amount of the complex of low density lipoproteins and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39026, PMID:8301098]
synonym: "elevated circulating LDL phospholipid level" EXACT []
is_a: MP:0020128 ! increased circulating non-HDL phospholipid level
is_a: MP:0021040 ! abnormal circulating LDL phospholipid level
property_value: dc:date "2021-12-15T21:04:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021043
name: decreased circulating LDL phospholipid level
def: "decrease in the amount of the complex of low density lipoproteins and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39026, PMID:8301098]
synonym: "reduced circulating LDL phospholipid level" EXACT []
is_a: MP:0020129 ! decreased circulating non-HDL phospholipid level
is_a: MP:0021040 ! abnormal circulating LDL phospholipid level
property_value: dc:date "2021-12-15T21:04:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021044
name: increased circulating VLDL phospholipid level
def: "increase in the amount of the complex of very low density lipoproteins and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39027, PMID:8301098]
synonym: "elevated circulating VLDL phospholipid level" EXACT []
is_a: MP:0020128 ! increased circulating non-HDL phospholipid level
is_a: MP:0021041 ! abnormal circulating VLDL phospholipid level
property_value: dc:date "2021-12-15T21:05:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021045
name: decreased circulating VLDL phospholipid level
def: "decrease in the amount of the complex of very low density lipoproteins and phospholipids in the blood, plasma, or serum" [CHEBI:16247, CHEBI:39027, PMID:8301098]
synonym: "reduced circulating VLDL phospholipid level" EXACT []
is_a: MP:0020129 ! decreased circulating non-HDL phospholipid level
is_a: MP:0021041 ! abnormal circulating VLDL phospholipid level
property_value: dc:date "2021-12-15T21:05:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021046
name: abnormal circulating HDL triglyceride level
def: "any anomaly in the amount of the complex of high density lipoproteins, small (4-13 nm) and dense (greater than 1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39025, PMID:8301098]
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0011969 ! abnormal circulating triglyceride level
property_value: dc:date "2021-12-17T16:13:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021047
name: abnormal circulating LDL triglyceride level
def: "any anomaly in the amount of the complex of low density lipoproteins, small (18-25 nm) and low density (1.019-1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39026, PMID:8301098]
is_a: MP:0010330 ! abnormal circulating lipoprotein level
is_a: MP:0011969 ! abnormal circulating triglyceride level
property_value: dc:date "2021-12-17T16:14:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021048
name: increased circulating LDL triglyceride level
def: "increase in the amount of the complex of low density lipoproteins, small (18-25 nm) and low density (1.019-1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39026, PMID:8301098]
synonym: "elevated circulating LDL triglyceride level" EXACT []
is_a: MP:0021047 ! abnormal circulating LDL triglyceride level
property_value: dc:date "2021-12-17T16:14:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021049
name: decreased circulating LDL triglyceride level
def: "decrease in the amount of the complex of low density lipoproteins, small (18-25 nm) and low density (1.019-1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39026, PMID:8301098]
synonym: "reduced circulating LDL triglyceride level" EXACT []
is_a: MP:0021047 ! abnormal circulating LDL triglyceride level
property_value: dc:date "2021-12-17T16:14:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021050
name: increased circulating HDL triglyceride level
def: "increase in the amount of the complex of high density lipoproteins, small (4-13 nm) and dense (greater than 1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39025, PMID:8301098]
synonym: "elevated circulating HDL triglyceride level" EXACT []
is_a: MP:0021046 ! abnormal circulating HDL triglyceride level
property_value: dc:date "2021-12-17T16:15:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021051
name: decreased circulating HDL triglyceride level
def: "decrease in the amount of the complex of high density lipoproteins, small (4-13 nm) and dense (greater than 1.063 g/ml) particles, and triglyceride in the blood, plasma, or serum" [CHEBI:17855, CHEBI:39025, PMID:8301098]
synonym: "reduced circulating HDL triglyceride level" EXACT []
is_a: MP:0021046 ! abnormal circulating HDL triglyceride level
property_value: dc:date "2021-12-17T16:15:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021052
name: abnormal renal arterial blood pressure regulation
def: "any anomaly in the processes that modulate the force with which blood travels through the renal circulatory system" [PMID:10070148]
is_a: MP:0010695 ! abnormal blood pressure regulation
property_value: dc:date "2021-12-17T20:36:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021053
name: abnormal renal arterial blood pressure
def: "any anomaly in the tension of the blood within the renal arteries or arterioles" [PMID:10070148]
is_a: MP:0001544 ! abnormal cardiovascular system physiology
is_a: MP:0002136 ! abnormal kidney physiology
property_value: dc:date "2021-12-17T20:41:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021054
name: increased renal arterial blood pressure
def: "increase in the tension of the blood within the renal arteries or arterioles" [PMID:10070148]
synonym: "elevated renal arterial blood pressure" EXACT []
is_a: MP:0021053 ! abnormal renal arterial blood pressure
property_value: dc:date "2021-12-17T20:46:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021055
name: decreased renal arterial blood pressure
def: "decrease in the tension of the blood within the renal arteries or arterioles" [PMID:10070148]
synonym: "reduced renal arterial blood pressure" EXACT []
is_a: MP:0021053 ! abnormal renal arterial blood pressure
property_value: dc:date "2021-12-17T20:46:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021056
name: abnormal tumor vascular morphology
def: "any structural anomaly of the network of tubes that carries blood within and/or around tumors" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0010639 ! abnormal tumor pathology
property_value: dc:date "2021-12-17T21:28:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021057
name: abnormal tumor perivascular space morphology
def: "any anomaly in the structure of the extracellular space bounded by capillary endothelium on one side and parenchymal basement membrane on the other side in tumor blood vessels" [PMID:16416090]
synonym: "abnormal tumor Virchow-Robin space morphology" EXACT []
is_a: MP:0021056 ! abnormal tumor vascular morphology
property_value: dc:date "2021-12-17T21:35:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-7698-0055
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021058
name: increased tumor perivascular space size
def: "increase in the size of the perivascular space in tumors" [PMID:16416090]
synonym: "increased tumor Virchow-Robin space size" EXACT []
is_a: MP:0021057 ! abnormal tumor perivascular space morphology
property_value: dc:date "2021-12-17T21:40:13Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-7698-0055
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021059
name: decreased tumor perivascular space size
def: "decrease in the size of the perivascular space in tumors" [PMID:16416090]
synonym: "decreased tumor Virchow-Robin space size" EXACT []
is_a: MP:0021057 ! abnormal tumor perivascular space morphology
property_value: dc:date "2021-12-17T21:40:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-7698-0055
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021060
name: abnormal tumor pericyte morphology
def: "any structural anomaly of the connective tissue cells that occur around capillaries or other small blood vessels within a tumor" [CL:0000669, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal tumor adventitial reticular cell morphology" EXACT []
synonym: "abnormal tumor cell of Rouget morphology" EXACT []
synonym: "abnormal tumor pericyte of Rouget morphology" EXACT []
is_a: MP:0021056 ! abnormal tumor vascular morphology
property_value: dc:date "2022-01-11T19:30:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021061
name: abnormal tumor pericyte number
def: "any anomaly in the number of pericytes found in the perivascular area of a tumor" [https://orcid.org/0000-0003-4606-0597, PMID:16416090]
is_a: MP:0021060 ! abnormal tumor pericyte morphology
property_value: dc:date "2022-01-11T19:38:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021062
name: increased tumor pericyte number
def: "increase in the number of pericytes found in the perivascular area of a tumor" [https://orcid.org/0000-0003-4606-0597, PMID:16416090]
synonym: "elevated tumor pericyte number" EXACT []
is_a: MP:0021061 ! abnormal tumor pericyte number
property_value: dc:date "2022-01-11T19:39:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021063
name: decreased tumor pericyte number
def: "decrease in the number of pericytes found in the perivascular area of a tumor" [https://orcid.org/0000-0003-4606-0597, PMID:16416090]
synonym: "reduced tumor pericyte number" EXACT []
is_a: MP:0021061 ! abnormal tumor pericyte number
property_value: dc:date "2022-01-11T19:39:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021064
name: decreased tumor nonattached pericyte number
def: "decrease in the number of pericytes that have not formed attachments to tumor blood vessels" [PMID:16416090]
synonym: "reduced tumor nonattached pericyte number" EXACT []
is_a: MP:0021063 ! decreased tumor pericyte number
property_value: dc:date "2022-01-11T19:39:49Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021065
name: decreased tumor attached pericyte number
def: "decrease in the number of pericytes that have formed attachments to tumor blood vessels" [PMID:16416090]
synonym: "reduced tumor attached pericyte number" EXACT []
is_a: MP:0021063 ! decreased tumor pericyte number
property_value: dc:date "2022-01-11T19:40:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021066
name: increased tumor nonattached pericyte number
def: "increase in the number of pericytes that have not formed attachments to tumor blood vessels" [PMID:16416090]
synonym: "elevated tumor nonattached pericyte number" EXACT []
is_a: MP:0021062 ! increased tumor pericyte number
property_value: dc:date "2022-01-11T19:40:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021067
name: increased tumor attached pericyte number
def: "increase in the number of pericytes that have formed attachments to tumor blood vessels" [PMID:16416090]
synonym: "elevated tumor attached pericyte number" EXACT []
is_a: MP:0021062 ! increased tumor pericyte number
property_value: dc:date "2022-01-11T19:40:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021068
name: abnormal nitric oxide synthase level
def: "any anomaly in the concentration of the enzyme(s) that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "abnormal NOS level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: dc:date "2022-01-11T21:27:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021069
name: decreased nitric oxide synthase 1 level
def: "reduction in the concentration of the constitutive neuronal enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "decreased nNOS level" EXACT []
synonym: "decreased NOS1 level" EXACT []
is_a: MP:0014453 ! decreased nitric oxide synthase level
is_a: MP:0021076 ! abnormal nitric oxide synthase 1 level
property_value: dc:date "2022-01-11T21:28:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021070
name: increased nitric oxide synthase 1 level
def: "elevated concentration of the constitutive neuronal enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [PMID:32048631] {comment="https://orcid.org/0000-0003-3645-6803"}
synonym: "increased nNOS level" EXACT []
synonym: "increased NOS1 level" EXACT []
is_a: MP:0014452 ! increased nitric oxide synthase level
is_a: MP:0021076 ! abnormal nitric oxide synthase 1 level
property_value: dc:date "2022-01-11T21:28:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021071
name: decreased nitric oxide synthase 2 level
def: "reduction in the concentration of the inducible enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803] {comment="PMID:32048631"}
synonym: "decreased iNOS level" EXACT []
synonym: "decreased NOS2 level" EXACT []
is_a: MP:0014453 ! decreased nitric oxide synthase level
is_a: MP:0021077 ! abnormal nitric oxide synthase 2 level
property_value: dc:date "2022-01-11T21:29:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021072
name: increased nitric oxide synthase 2 level
def: "elevated concentration of the inducible enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "increased iNOS level" EXACT []
synonym: "increased NOS2 level" EXACT []
is_a: MP:0014452 ! increased nitric oxide synthase level
is_a: MP:0021077 ! abnormal nitric oxide synthase 2 level
property_value: dc:date "2022-01-11T21:29:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021073
name: decreased nitric oxide synthase 3 level
def: "reduction in the concentration of the constitutive endothelial enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "decreased eNOS level" EXACT []
synonym: "decreased NOS3 level" EXACT []
is_a: MP:0014453 ! decreased nitric oxide synthase level
is_a: MP:0021075 ! abnormal nitric oxide synthase 3 level
property_value: dc:date "2022-01-11T21:29:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021074
name: increased nitric oxide synthase 3 level
def: "increase in the concentration of the constitutive endothelial enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "increased eNOS level" EXACT []
synonym: "increased NOS3 level" EXACT []
is_a: MP:0014452 ! increased nitric oxide synthase level
is_a: MP:0021075 ! abnormal nitric oxide synthase 3 level
property_value: dc:date "2022-01-11T21:29:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021075
name: abnormal nitric oxide synthase 3 level
def: "any anomaly in the concentration of the constitutive endothelial enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [PMID:32048631]
synonym: "abnormal eNOS level" EXACT []
synonym: "abnormal NOS3 level" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: dc:date "2022-01-11T21:30:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021076
name: abnormal nitric oxide synthase 1 level
def: "any anomaly in the concentration of the constitutive neuronal enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [PMID:32048631]
synonym: "abnormal nNOS level" EXACT []
synonym: "abnormal NOS1 level" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: dc:date "2022-01-11T21:30:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021077
name: abnormal nitric oxide synthase 2 level
def: "any anomaly in the concentration of the inducible enzyme that catalyzes the synthesis of nitric oxide from L-arginine" [PMID:32048631]
synonym: "abnormal iNOS level" EXACT []
synonym: "abnormal NOS2 level" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: dc:date "2022-01-11T21:30:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021078
name: abnormal nitric oxide synthase 2 to nitric oxide synthase 3 ratio
def: "any anomaly in the ratio of the concentrations of nitric oxide synthase 2 to nitric oxide synthase 3, two of the enzymes that catalyze the synthesis of nitric oxide from L-arginine" [PMID:32048631]
synonym: "abnormal iNOS/eNOS ratio" EXACT []
synonym: "abnormal NOS2/NOS3 ratio" EXACT []
is_a: MP:0021068 ! abnormal nitric oxide synthase level
property_value: dc:date "2022-01-11T21:40:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021079
name: increased nitric oxide synthase 2 to nitric oxide synthase 3 ratio
def: "increase in the ratio of the concentrations of nitric oxide synthase 2 and nitric oxide synthase 3, two of the enzymes that catalyze the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "elevated NOS2/NOS3 ratio" EXACT []
synonym: "increased iNOS/eNOS ratio" EXACT []
is_a: MP:0014452 ! increased nitric oxide synthase level
is_a: MP:0021078 ! abnormal nitric oxide synthase 2 to nitric oxide synthase 3 ratio
property_value: dc:date "2022-01-11T21:40:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021080
name: decreased nitric oxide synthase 2 to nitric oxide synthase 3 ratio
def: "decrease in the ratio of the concentrations of nitric oxide synthase 2 and nitric oxide synthase 3, two of the enzymes that catalyze the synthesis of nitric oxide from L-arginine" [https://orcid.org/0000-0003-3645-6803, PMID:32048631]
synonym: "decreased iNOS/eNOS ratio" EXACT []
synonym: "reduced NOS2/NOS3 ratio" EXACT []
is_a: MP:0014453 ! decreased nitric oxide synthase level
is_a: MP:0021078 ! abnormal nitric oxide synthase 2 to nitric oxide synthase 3 ratio
property_value: dc:date "2022-01-11T21:41:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021081
name: abnormal ribosomal stalling
def: "any anomaly in the ability of cells to clear a ribosomal complex that has become stuck in the process of translational elongation" [PMID:33966939]
is_a: MP:0013273 ! abnormal translational elongation
is_a: MP:0014240 ! abnormal ribosome physiology
property_value: dc:date "2022-02-15T19:20:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021082
name: abnormal cerebrospinal fluid amyloid beta 42 isoform level
def: "any anomaly in the amount of amyloid beta 42 found in cerebrospinal fluid" [PMID:31391004]
synonym: "abnormal cerebrospinal fluid Abeta 42 level" EXACT []
synonym: "abnormal cerebrospinal fluid beta amyloid 42 level" EXACT []
is_a: MP:0021024 ! abnormal cerebrospinal fluid physiology
is_a: MP:0021149 ! abnormal amyloid beta protein level
property_value: dc:date "2022-02-15T20:43:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021083
name: increased cerebrospinal fluid amyloid beta 42 isoform level
def: "increase in the amount of amyloid beta 42 found in cerebrospinal fluid" [PMID:31391004]
synonym: "elevated cerebrospinal fluid Abeta 42 level" EXACT []
synonym: "increased cerebrospinal fluid beta amyloid 42 level" EXACT []
is_a: MP:0021082 ! abnormal cerebrospinal fluid amyloid beta 42 isoform level
is_a: MP:0021150 ! increased amyloid beta protein level
property_value: dc:date "2022-02-15T20:44:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021084
name: decreased cerebrospinal fluid amyloid beta 42 isoform level
def: "reduction in the amount of amyloid beta 42 found in cerebrospinal fluid" [PMID:31391004]
synonym: "decreased cerebrospinal fluid beta amyloid 42 level" EXACT []
synonym: "reduced cerebrospinal fluid Abeta 42 level" EXACT []
is_a: MP:0021082 ! abnormal cerebrospinal fluid amyloid beta 42 isoform level
is_a: MP:0021151 ! decreased amyloid beta protein level
property_value: dc:date "2022-02-15T20:44:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021085
name: increased DNA replication
def: "any anomaly in the chemical reactions and pathways resulting an increase in new strands of DNA being synthesized" [GO:0006260, PMID:29548889]
synonym: "accelerated DNA replication" RELATED []
synonym: "elevated DNA replication" EXACT []
is_a: MP:0008057 ! abnormal DNA replication
property_value: dc:date "2022-02-15T21:23:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021086
name: decreased DNA replication
def: "any anomaly in the chemical reactions and pathways resulting a decrease in new strands of DNA being synthesized" [GO:0006260, PMID:29548889]
synonym: "decelerated DNA replication" RELATED []
synonym: "reduced DNA replication" EXACT []
is_a: MP:0008057 ! abnormal DNA replication
property_value: dc:date "2022-02-15T21:24:04Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-9553-7227
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021087
name: abnormal spatial memory extinction
def: "any anomaly in the process by which a previously acquired spatial memory is lost by learned suppression" [PMID:31133825]
is_a: MP:0008414 ! abnormal spatial reference memory
property_value: dc:date "2022-02-15T21:54:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021088
name: impaired spatial memory extinction
def: "decrease in or deceleration of the process by which a previously acquired spatial memory is lost by learned suppression" [PMID:31133825]
is_a: MP:0021087 ! abnormal spatial memory extinction
property_value: dc:date "2022-02-15T21:54:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021089
name: enhanced spatial memory extinction
def: "increase in or acceleration of the process by which a previously acquired spatial memory is lost by learned suppression" [PMID:31133825]
is_a: MP:0021087 ! abnormal spatial memory extinction
property_value: dc:date "2022-02-15T21:54:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021090
name: abnormal dendrite arborization pattern
def: "any anomaly in the structure of the tree-like branching pattern of the dendritic arbor" [PMID:20404840]
synonym: "abnormal dendritic branching pattern" EXACT []
is_a: MP:0008143 ! abnormal dendrite morphology
property_value: dc:date "2022-02-22T19:31:50Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021091
name: abnormal dorsal interneuron morphology
def: "any structural anomaly spinal cord interneurons that arise from the dorsal pool of progenitor cells and are associated primarily with sensory processing" [PMID:26136656]
synonym: "abnormal dI morphology" EXACT []
is_a: MP:0004100 ! abnormal spinal cord interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021092
name: abnormal dorsal interneuron 1 morphology
def: "any structural anomaly of the dorsal interneurons that migrate to the deep dorsal horn and intermediate gray tissue, recieve proprioceptive input from the periphery, form commissural projections of dorsal and ventral spinaocerebellar tracts, and are characterized by expression of Atoh1, Brn3a, Barhl1, and Lhx9" [PMID:26136656]
synonym: "abnormal dI1 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021093
name: abnormal dorsal interneuron 2 morphology
def: "any structural anomaly of the dorsal interneurons that are ascending, contralaterally projecting, relay interneurons, migrate to the intermediate spinal cord and ventral horn, and are characterized by expression of Olig3, Nlgn1, Brn3a, Foxd3, Lhx1, and Lhx5" [PMID:26136656]
synonym: "abnormal dI2 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021094
name: abnormal dorsal interneuron 3 morphology
def: "any structural anomaly of the dorsal interneurons that are excitatory, located in the deep dorsal horn and intermediate spinal cord, target motor neurons monosynaptically, have axons projecting rostrally, ipsilaterally, and longitudinally, and are characterized by expression of Acsl1, Gsh2, Brn3a, Tlx3, Isl1, and Drg11" [PMID:26136656]
synonym: "abnormal dI3 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021095
name: abnormal dorsal interneuron 4 morphology
def: "any structural anomaly of the dorsal interneurons that are GABAergic, project ipsilaterally, are somatosensory associative, migrate to the deep dorsal horn, and are characterized by expression of Msx1, Ascl1, Gsh1, Gsh2, Lbx1, Pax2, Lhx1, Lhx5, and Ptf1a" [PMID:26136656]
synonym: "abnormal dI4 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021096
name: abnormal dorsal interneuron 5 morphology
def: "any structural anomaly of the dorsal interneurons that are roof-plate independent, glutamatergic, somatosensory, project contralaterally, and are characterized by expression of Pax6, Irx3, Dbx2, Ascl1, Lbx1, Tlx3, Lmxb1b, and Brn3a" [PMID:26136656]
synonym: "abnormal dI5 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021097
name: abnormal dorsal interneuron 6 morphology
def: "any structural anomaly of the dorsal interneurons that are roof-plate independent, commissural, inhibitory, and are characterized by expression of Pax6, Pax7, Irx3, Dbx2, Ngn1, Ngn2, Wt1, and Lbx1" [PMID:26136656]
synonym: "abnormal dI6 morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021098
name: abnormal late-born dorsal interneuron morphology
def: "any structural anomaly of the dorsal interneurons that are born during a second wave of neurogenesis, are located in the superficial dorsal horn, and are characterized by expression of Ascl1, Gsh1, Gsh2, Ptf1, and Lbx1" [PMID:26136656]
synonym: "abnormal dIL morphology" EXACT []
is_a: MP:0021091 ! abnormal dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021099
name: abnormal dorsal interneuron LA morphology
def: "any structural anomaly of the late-born dorsal interneurons that are roof-plate independent, and are dependent on expression of Ptf1a" [PMID:26136656]
synonym: "abnormal dILA morphology" EXACT []
is_a: MP:0021098 ! abnormal late-born dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021100
name: abnormal dorsal interneuron LB morphology
def: "any structural anomaly of the late-born dorsal interneurons that project ipsilaterally, integrate input from cutaneous sensory neurons that detect noxious stimuli, and are characterized by expression of Drg11, Tlx3, and Slc17a6" [PMID:26136656]
synonym: "abnormal dILB morphology" EXACT []
is_a: MP:0021098 ! abnormal late-born dorsal interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021101
name: abnormal ventral interneuron morphology
def: "any structural anomaly spinal cord interneurons that arise from the ventral pool of progenitor cells, are mostly found in the ventral cord and are grossly associated with motor function" [PMID:26136656]
synonym: "abnormal V interneuron morphology" EXACT []
is_a: MP:0004100 ! abnormal spinal cord interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021102
name: abnormal ventral interneuron 0 morphology
def: "any structural anomaly of the ventral interneurons that are primarily contralateral, receive inputs from ipsilateral projecting V2a interneurons, and are characterized by expression of Evx1, Dbx1, Dbx2, Pax6 and Irx3" [PMID:26136656]
synonym: "abnormal V0 morphology" EXACT []
is_a: MP:0021101 ! abnormal ventral interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021103
name: abnormal ventral interneuron 1 morphology
def: "any structural anomaly of the ventral interneurons that appear to control burst durations and are characterized by expression of En1, Foxd3, Dbx2, Pax6, and Irx3" [PMID:26136656]
synonym: "abnormal V1 morphology" EXACT []
is_a: MP:0021101 ! abnormal ventral interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021104
name: abnormal ventral interneuron 2 morphology
def: "any structural anomaly of the ventral interneurons that project ipsilaterally, extend axons caudally across several segments, have both excitatory (V2a) and inhibitory (V2b) subclasses, and are characterized by expression of Chx10, Gata3, Irx3, and Lhx3" [PMID:26136656]
synonym: "abnormal V2 morphology" EXACT []
is_a: MP:0021101 ! abnormal ventral interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021105
name: abnormal ventral interneuron 3 morphology
def: "any structural anomaly of the ventral interneurons that are glutamatergic, predominantly project contralaterally and caudally, form connections with V1, V2 and lamina VIII interneurons, and are characterized by expression of Nkx2-2, Nkx601, Ngn3, and Sim1" [PMID:26136656]
synonym: "abnormal V3 morphology" EXACT []
is_a: MP:0021101 ! abnormal ventral interneuron morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021106
name: abnormal secondary ovarian follicle morphology
def: "any structural anomaly in a maturing ovarian follicle that has two or more layers of granulosa cells but lacks antra" [UBERON:0000036]
synonym: "abnormal folliculus ovaricus secondarius morphology" EXACT []
synonym: "abnormal pre-antral follicle morphology" EXACT []
synonym: "abnormal preantral follicle morphology" EXACT []
is_a: MP:0001131 ! abnormal ovarian follicle morphology
property_value: dc:date "2022-02-25T20:51:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021107
name: retina fold
def: "presence of one or more wrinkles projecting outward from the surface of the retina" [HP:0008052]
synonym: "retinal fold" EXACT []
synonym: "retinal folds" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: dc:date "2022-03-08T20:57:23Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021108
name: intestinal epithelium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the intestinal epithelium, typically resulting in increased size" [PMID:22042863]
synonym: "hyperplastic intestinal epithelium" EXACT []
is_a: MP:0000488 ! abnormal intestinal epithelium morphology
property_value: dc:date "2022-03-09T16:08:04Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021109
name: intestinal epithelium hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the intestinal epithelium, typically resulting in increased size" [http://orcid.org/0000-0003-4606-0597]
synonym: "hypoplastic intestinal epithelium" EXACT []
is_a: MP:0000488 ! abnormal intestinal epithelium morphology
property_value: dc:date "2022-03-09T16:08:21Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021110
name: increased social investigation
def: "increase in the tendency for animals to approach and examine conspecifics" [PMID:15988472]
is_a: MP:0001360 ! abnormal social investigation
property_value: dc:date "2022-04-05T20:46:21Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021111
name: decreased social investigation
def: "decrease in the tendency for animals to approach and examine conspecifics" [PMID:15347806]
synonym: "reduced social investigation" EXACT []
is_a: MP:0001360 ! abnormal social investigation
property_value: dc:date "2022-04-05T20:46:37Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021112
name: impaired social recognition
def: "reduction in the ability of an individual to recognize another individual of the same species during repeated encounters" [PMID:11950245]
synonym: "decreased social memory retention" EXACT []
is_a: MP:0020396 ! abnormal social recognition
property_value: dc:date "2022-04-05T20:54:16Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021113
name: enhanced social recognition
def: "increase in the ability of an individual to recognize another individual of the same species during repeated encounters" [PMID:11950245]
synonym: "increased social memory retention" EXACT []
is_a: MP:0020396 ! abnormal social recognition
property_value: dc:date "2022-04-05T20:56:42Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021114
name: social amnesia
def: "inability of an individual to recognize another individual of the same species during repeated encounters" [PMID:16249339]
is_a: MP:0021112 ! impaired social recognition
property_value: dc:date "2022-04-05T20:58:43Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021115
name: abnormal aggression towards conspecific
def: "any anomaly in the level of domineering, assaultive posture and/or hostile physical action displayed toward another individual(s) of the same species" [ISBN:0-395-70869-9, ISBN:0-683-40008-8]
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior
property_value: dc:date "2022-04-15T17:02:10Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021116
name: abnormal heterospecific interaction behavior
def: "any anomaly in the normal behavior of a mammal(s) in response to encountering or engaging with a member(s) of another species" [http://orcid.org/0000-0003-4606-0597]
synonym: "abnormal heterospecific interaction behaviour" EXACT []
is_a: MP:0004924 ! abnormal behavior
property_value: dc:date "2022-04-15T17:19:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021117
name: abnormal huddling behavior
def: "any anomaly in the tendency of a group of mammals to congregate together maintaining close body contact" [http://purl.obolibrary.org/obo/NBO_0000052]
synonym: "abnormal huddling behaviour" EXACT []
is_a: MP:0002557 ! abnormal social/conspecific interaction behavior
property_value: dc:date "2022-04-15T18:11:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021118
name: abnormal paternal behavior
def: "any anomaly in any response from the father or attending male related to the ability of young to thrive" [https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal paternal behaviour" EXACT []
is_a: MP:0002068 ! abnormal parental behavior
property_value: dc:date "2022-04-15T18:55:24Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021119
name: abnormal auditory behavior
def: "any anomaly in a behavior related to the actions or reactions of an organism in response to a sound" [http://purl.obolibrary.org/obo/NBO_0000316]
synonym: "abnormal auditory related behavior" EXACT []
synonym: "abnormal behavioural response to sound" EXACT []
is_a: MP:0014114 ! abnormal cognition
property_value: dc:date "2022-04-15T19:53:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021120
name: abnormal visual behavior
def: "any anomaly in a behavior related to the actions or reactions of an organism in response to a visual stimulus" [http://purl.obolibrary.org/obo/NBO_0000314]
synonym: "abnormal visual related behaviour" EXACT []
is_a: MP:0014114 ! abnormal cognition
property_value: dc:date "2022-04-15T20:00:44Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021121
name: abnormal rhythmic behavior
def: "any anomaly in any specific action or reaction of an organism that recurs with measured regularity" [http://purl.obolibrary.org/obo/GO_0007622]
synonym: "abnormal rhythmic behaviour" EXACT []
is_a: MP:0004924 ! abnormal behavior
property_value: dc:date "2022-04-15T20:12:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021122
name: abnormal trimethylamine N-oxide level
def: "any anomaly in the amount of the tertiary amine oxide resulting from the oxidation typically by gut bacteria of the amino group of trimethylamine" [http://purl.obolibrary.org/obo/CHEBI_15724, https://orcid.org/0000-0001-6624-9261]
comment: high levels of this compound are associated with heart disease, hardening of arteries, diabetes, and colon cancer
synonym: "abnormal N,N-dimethylmethanamine oxide level" EXACT []
synonym: "abnormal TMAO level" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:date "2022-04-19T18:20:20Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021123
name: increased trimethylamine N-oxide level
def: "elevation in the amount of the tertiary amine oxide resulting from the oxidation typically by gut bacteria of the amino group of trimethylamine" [http://purl.obolibrary.org/obo/CHEBI_15724]
synonym: "elevated N,N-dimethylmethanamine oxide level" EXACT []
synonym: "increased TMAO level" EXACT []
is_a: MP:0021122 ! abnormal trimethylamine N-oxide level
property_value: dc:date "2022-04-19T18:27:55Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021124
name: decreased trimethylamine N-oxide level
def: "reduction in the amount of the tertiary amine oxide resulting from the oxidation typically by gut bacteria of the amino group of trimethylamine" [http://purl.obolibrary.org/obo/CHEBI_15724]
synonym: "decreased TMAO level" EXACT []
synonym: "reduced N,N-dimethylmethanamine oxide level" EXACT []
is_a: MP:0021122 ! abnormal trimethylamine N-oxide level
property_value: dc:date "2022-04-19T18:28:04Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021125
name: abnormal phosphocholine level
def: "any anomaly in the amount of the phosphate of choline an intermediate in the synthesis of phosphatidylcholine" [http://purl.obolibrary.org/obo/CHEBI_18132, https://orcid.org/0000-0001-6624-9261]
synonym: "abnormal N,N,N-trimethyl-2-(phosphonooxy)ethanaminium level" EXACT []
is_a: MP:0020885 ! abnormal phosphate level
is_a: MP:0030752 ! abnormal choline level
property_value: dc:date "2022-04-19T18:54:31Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021126
name: increased phosphocholine level
def: "greater than the normal amount of the phosphate of choline an intermediate in the synthesis of phosphatidylcholine" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated N,N,N-trimethyl-2-(phosphonooxy)ethanaminium level" EXACT []
is_a: MP:0014545 ! increased phosphate level
is_a: MP:0021125 ! abnormal phosphocholine level
property_value: dc:date "2022-04-19T18:54:49Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021127
name: decreased phosphocholine level
def: "less than the normal amount of the phosphate of choline an intermediate in the synthesis of phosphatidylcholine" [https://orcid.org/0000-0003-4606-0597]
synonym: "reduced N,N,N-trimethyl-2-(phosphonooxy)ethanaminium level" EXACT []
is_a: MP:0014546 ! decreased phosphate level
is_a: MP:0021125 ! abnormal phosphocholine level
property_value: dc:date "2022-04-19T18:55:02Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021128
name: increased choline level
def: "greater than the normal amount of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine" [https://orcid.org/0000-0003-4606-0597]
synonym: "elevated choline level" EXACT []
is_a: MP:0030752 ! abnormal choline level
property_value: dc:date "2022-04-19T18:59:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021129
name: abnormal glycerophosphocholine level
def: "any anomaly in the amount of the glycerol phosphate ester of a phosphocholine, one of two major forms of choline storage (the other is phosphocholine) in the cytosol" [http://purl.obolibrary.org/obo/CHEBI_36313, https://orcid.org/0000-0001-6624-9261]
is_a: MP:0004777 ! abnormal phospholipid level
property_value: dc:date "2022-04-19T19:31:55Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021130
name: decreased glycerophosphocholine level
def: "less than the normal amount of the glycerol phosphate ester of a phosphocholine, one of two major forms of choline storage (the other is phosphocholine) in the cytosol" [http://purl.obolibrary.org/obo/CHEBI_36313]
synonym: "reduced glycerophosphocholine level" EXACT []
is_a: MP:0014461 ! decreased lipid level
is_a: MP:0021129 ! abnormal glycerophosphocholine level
property_value: dc:date "2022-04-19T19:36:02Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021131
name: increased glycerophosphocholine level
def: "greater than the normal amount of the glycerol phosphate ester of a phosphocholine, one of two major forms of choline storage (the other is phosphocholine) in the cytosol" [http://purl.obolibrary.org/obo/CHEBI_36313]
synonym: "elevated glycerophosphocholine level" EXACT []
is_a: MP:0014460 ! increased lipid level
is_a: MP:0021129 ! abnormal glycerophosphocholine level
property_value: dc:date "2022-04-19T19:36:12Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021132
name: abnormal amino acid betaine level
def: "any anomaly in the amount of the amino acid-derived zwitterion in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms; often serving as methyl donor for various metabolic pathways" [http://purl.obolibrary.org/obo/CHEBI_22860, https://orcid.org/0000-0001-6624-9261]
synonym: "abnormal amino-acid betaine level" EXACT []
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: dc:date "2022-04-19T21:05:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021133
name: increased amino acid betaine level
def: "greater than the normal amount of the amino acid-derived zwitterion in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms" [] {def="CHEBI:22860"}
synonym: "elevated amino-acid betaine level" EXACT []
is_a: MP:0021132 ! abnormal amino acid betaine level
property_value: dc:date "2022-04-19T21:05:45Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021134
name: decreased amino acid betaine level
def: "less than the normal amount of the amino acid-derived zwitterion in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms" [] {def="CHEBI:22860"}
synonym: "reduced amino-acid betaine level" EXACT []
is_a: MP:0021132 ! abnormal amino acid betaine level
property_value: dc:date "2022-04-19T21:05:55Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021135
name: abnormal annulus fibrosus morphology
def: "any structural anomaly of the sturdy tire-like structure consisting of water and sturdy elastic collagen fibers that encases the gel-like center of the disk" [https://pubmed.ncbi.nlm.nih.gov/25954032, https://www.coloradospineinstitute.com/education/anatomy/intervertebral-discs/]
synonym: "abnormal anulus fibrosus morphology" EXACT []
is_a: MP:0004173 ! abnormal intervertebral disk morphology
property_value: dc:date "2022-05-18T19:59:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021136
name: abnormal vertebrae shape
def: "any anomaly in the characteristic surface outline or contour of the vertebrae" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0000137 ! abnormal vertebrae morphology
property_value: dc:date "2022-05-18T20:07:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021137
name: abnormal wedge-shaped vertebrae
def: "any anomaly in the angle between the upper endplate and the lower endplate of the vertebra such that one side is thicker than the other" [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044896/]
synonym: "vertebral wedging" EXACT []
synonym: "wedged vertebrae" EXACT []
is_a: MP:0021136 ! abnormal vertebrae shape
property_value: dc:date "2022-05-18T20:16:42Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021138
name: abnormal multifidus muscle morphology
def: "any structural anomaly in the small, triangular muscular and tendinous bundles located on either side of the spinal column that fill the groove between the transverse and spinous processes of the vertebrae" [https://en.wikipedia.org/wiki/Multifidus_muscle, https://www.physio-pedia.com/Multifidus_Muscle]
synonym: "abnormal multifidus morphology" EXACT []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
property_value: dc:date "2022-06-09T18:34:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021139
name: abnormal cardiac muscle calcium level
def: "any anomaly in the amount of calcium in the heart muscle" [PMID:32207065]
synonym: "abnormal cardiac muscle cell calcium level" EXACT []
synonym: "abnormal cardiac myocyte calcium level" EXACT []
synonym: "abnormal cardiomyocyte calcium level" EXACT []
synonym: "abnormal heart muscle cell calcium level" EXACT []
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
is_a: MP:0020879 ! abnormal calcium level
property_value: dc:date "2022-06-09T19:00:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5256-8683
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021140
name: increased cardiac muscle calcium level
def: "increase in the amount of calcium in the heart muscle" [PMID:32207065]
synonym: "increased cardiac muscle cell calcium level" EXACT []
synonym: "increased cardiac myocyte calcium level" EXACT []
synonym: "increased cardiomyocyte calcium level" EXACT []
synonym: "increased heart muscle cell calcium level" EXACT []
is_a: MP:0014537 ! increased calcium level
is_a: MP:0021139 ! abnormal cardiac muscle calcium level
property_value: dc:date "2022-06-09T19:09:30Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0000-0001-5256-8683

[Term]
id: MP:0021141
name: decreased cardiac muscle calcium level
def: "decrease in the amount of calcium in the heart muscle" [PMID:32207065]
synonym: "decreased cardiac muscle cell calcium level" EXACT []
synonym: "decreased cardiac myocyte calcium level" EXACT []
synonym: "decreased cardiomyocyte calcium level" EXACT []
synonym: "decreased heart muscle cell calcium level" EXACT []
synonym: "reduced cardiac myocyte calcium level" EXACT []
synonym: "reduced cardiomyocyte calcium level" EXACT []
synonym: "reduced heart muscle cell calcium level" EXACT []
is_a: MP:0014538 ! decreased calcium level
is_a: MP:0021139 ! abnormal cardiac muscle calcium level
property_value: dc:date "2022-06-09T19:09:43Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0000-0001-5256-8683

[Term]
id: MP:0021142
name: abnormal brain N-acetyl-L-aspartic acid level
def: "any anomaly in the amount of the derivative of the amino acid aspartic acid in which the acyl group is acetyl and has the chemical formula C6H9NO5 in the brain tissue" [http://purl.obolibrary.org/obo/CHEBI_21547, https://en.wikipedia.org/wiki/N-Acetylaspartic_acid, PMID:10820213]
synonym: "aberrant brain N-acetyl-L-aspartate level" EXACT []
synonym: "aberrant brain NAA level" EXACT []
synonym: "abnormal brain (2S)-2-acetamidobutanedioic acid level" EXACT []
synonym: "abnormal brain N-acetyl-L-aspartate level" EXACT []
synonym: "abnormal brain N-Acetylaspartic acid level" EXACT []
synonym: "abnormal brain NAA level" EXACT []
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: dc:date "2022-06-09T20:13:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021143
name: increased brain N-acetyl-L-aspartic acid level
def: "an increase in the amount of N-acetyl-L-aspartic acid in the brain tissue" [] {comment="PMID:10820213"}
synonym: "increased brain (2S)-2-acetamidobutanedioic acid level" EXACT []
synonym: "increased brain N-acetyl-L-aspartate level" EXACT []
synonym: "increased brain NAA level" EXACT []
is_a: MP:0021142 ! abnormal brain N-acetyl-L-aspartic acid level
property_value: dc:date "2022-06-09T20:13:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021144
name: decreased brain N-acetyl-L-aspartic acid level
def: "a decrease in the amount of N-acetyl-L-aspartic acid in the brain tissue" []
synonym: "decreased brain (2S)-2-acetamidobutanedioic acid level" EXACT [PMID:10820213]
synonym: "decreased brain N-acetyl-L-aspartate level" EXACT []
synonym: "reduced brain N-acetyl-L-aspartate level" EXACT []
synonym: "reduced brain NAA level" EXACT []
is_a: MP:0021142 ! abnormal brain N-acetyl-L-aspartic acid level
property_value: dc:date "2022-06-09T20:13:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021145
name: abnormal amino acid derivative level
def: "any anomaly in the amount of a compound derived from an amino acid from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom" [http://purl.obolibrary.org/obo/CHEBI_83821]
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:date "2022-06-09T20:35:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021146
name: AA amyloidosis
def: "an accumulation of extracellular serum amyloid A deposits in tissues of the body" [HP:4000041, https://www.webmd.com/cancer/lymphoma/amyloidosis-symptoms-causes-treatments]
synonym: "increased amyloid type A protein deposition" EXACT []
is_a: MP:0000604 ! amyloidosis
property_value: dc:date "2022-06-10T17:58:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021147
name: renal amyloidosis
def: "an accumulation of extracellular amyloid deposits in tissues of the kidney" [HP:0001917]
synonym: "increased kidney amyloid deposition" EXACT []
is_a: MP:0000604 ! amyloidosis
property_value: dc:date "2022-06-10T18:14:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021148
name: cardiac amyloidosis
def: "an accumulation of extracellular amyloid deposits in tissues of the heart" [HP:0030843]
synonym: "increased heart amyloid deposition" EXACT []
is_a: MP:0000604 ! amyloidosis
property_value: dc:date "2022-06-10T18:17:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021149
name: abnormal amyloid beta protein level
def: "any anomaly in the amount of the cleaved APP amyloid beta protein fragment" [PMID:31391004]
synonym: "abnormal Abeta level" EXACT []
synonym: "abnormal beta amyloid level" EXACT []
is_a: MP:0008469 ! abnormal protein level
property_value: dc:date "2022-06-10T18:20:49Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-2307-1226
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021150
name: increased amyloid beta protein level
def: "increase in the amount of the cleaved APP amyloid beta protein fragment" [PMID:31391004]
is_a: MP:0021149 ! abnormal amyloid beta protein level
property_value: dc:date "2022-06-10T18:24:46Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021151
name: decreased amyloid beta protein level
def: "decrease in the amount of the cleaved APP amyloid beta protein fragment" [PMID:31391004]
synonym: "reduced amyloid beta protein level" EXACT []
is_a: MP:0021149 ! abnormal amyloid beta protein level
property_value: dc:date "2022-06-10T18:24:54Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021152
name: abnormal amyloid deposition
def: "any anomaly in the formation of extracellular amyloid deposits in tissues of the body" [PMID:16785251]
is_a: MP:0005376 ! homeostasis/metabolism phenotype
property_value: dc:date "2022-06-10T18:33:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021153
name: decreased amyloid deposition
def: "reduction in the formation of extracellular amyloid deposits in tissues of the body" [PMID:16785251]
synonym: "decreased amyloid deposits" EXACT []
synonym: "reduced amyloid deposition" EXACT []
is_a: MP:0021152 ! abnormal amyloid deposition
property_value: dc:date "2022-06-10T18:34:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021154
name: hepatic amyloidosis
def: "an accumulation of extracellular amyloid deposits in tissues of the liver" [HP:0012280, PMID:19041304]
synonym: "increased liver amyloid deposition" EXACT []
is_a: MP:0000604 ! amyloidosis
property_value: dc:date "2022-06-10T18:44:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021155
name: abnormal heart left ventricle wall thickness
def: "anomaly in the depth of the cardiac wall of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020135 ! abnormal heart ventricle wall thickness
is_a: MP:0031533 ! abnormal heart left ventricle wall morphology
property_value: dc:date "2022-06-21T15:44:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021156
name: abnormal heart right ventricle wall thickness
def: "anomaly in the depth of the cardiac wall of the heart right ventricle" [https://orcid.org/0000-0003-4606-0597]
is_a: MP:0020135 ! abnormal heart ventricle wall thickness
is_a: MP:0031534 ! abnormal heart right ventricle wall morphology
property_value: dc:date "2022-06-21T15:44:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021157
name: increased heart left ventricle wall thickness
def: "increase in the depth of the cardiac wall of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick left ventricular wall" EXACT []
is_a: MP:0002953 ! thick ventricular wall
is_a: MP:0021155 ! abnormal heart left ventricle wall thickness
property_value: dc:date "2022-06-21T15:45:04Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021158
name: decreased heart left ventricle wall thickness
def: "decrease in the depth of the cardiac wall of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thin left ventricular wall" EXACT []
is_a: MP:0000280 ! thin ventricular wall
is_a: MP:0021155 ! abnormal heart left ventricle wall thickness
property_value: dc:date "2022-06-21T15:45:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021159
name: increased heart right ventricle wall thickness
def: "increase in the depth of the cardiac wall of the heart right ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick right ventricular wall" EXACT []
is_a: MP:0002953 ! thick ventricular wall
is_a: MP:0021156 ! abnormal heart right ventricle wall thickness
property_value: dc:date "2022-06-21T15:45:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021160
name: decreased heart right ventricle wall thickness
def: "decrease in the depth of the cardiac wall of the heart right ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thin right ventricular wall" EXACT []
is_a: MP:0000280 ! thin ventricular wall
is_a: MP:0021156 ! abnormal heart right ventricle wall thickness
property_value: dc:date "2022-06-21T15:45:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021161
name: increased heart left ventricle posterior wall thickness
def: "increase in the depth of the cardiac wall on the posterior side of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick left ventricular posterior wall" EXACT []
is_a: MP:0021157 ! increased heart left ventricle wall thickness
property_value: dc:date "2022-06-21T16:58:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021162
name: increased heart left ventricle anterior wall thickness
def: "increase in the depth of the cardiac wall on the anterior side of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick left ventricular anterior wall" EXACT []
is_a: MP:0021157 ! increased heart left ventricle wall thickness
property_value: dc:date "2022-06-21T16:59:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021163
name: increased heart left ventricle septal wall thickness
def: "increase in the depth of the cardiac septal wall of the heart left ventricle" [https://orcid.org/0000-0003-4606-0597]
synonym: "thick left ventricular septal wall" EXACT []
is_a: MP:0010724 ! thick interventricular septum
is_a: MP:0021157 ! increased heart left ventricle wall thickness
property_value: dc:date "2022-06-21T16:59:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021164
name: oral cleft
def: "fissure in the tissues of the upper lip and/or roof of the mouth" [HP:0000202, https://www.mayoclinic.org/diseases-conditions/cleft-palate/symptoms-causes/syc-20370985]
synonym: "cleft of the mouth" EXACT []
synonym: "oral clefting" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology
property_value: dc:date "2022-06-21T17:38:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021165
name: behavioral developmental delay
def: "late onset of the appearance or disappearance of a behavior or behavioral milestone during the development of an organism compared to controls" [https://www.yalemedicine.org/conditions/developmental-delay, PMID:29395075]
is_a: MP:0004924 ! abnormal behavior
property_value: dc:date "2022-06-21T18:24:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021166
name: delayed palatal shelf elevation
def: "delay in the timing of the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:34150743]
is_a: MP:0009885 ! abnormal palatal shelf elevation
property_value: dc:date "2022-07-06T19:24:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021167
name: abnormal behavioral response to oxycodone
def: "anomaly in the behavioral response induced by the semisynthetic opioid of formula C18H21NO4 that is derived from thebaine" [http://purl.obolibrary.org/obo/CHEBI_7852, https://orcid.org/0000-0003-4606-0597]
synonym: "abnormal behavioural response to 14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one" EXACT []
is_a: MP:0009748 ! abnormal behavioral response to addictive substance
property_value: dc:date "2022-07-06T19:27:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-6624-9261
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021168
name: enhanced behavioral response to oxycodone
def: "increased sensitivity to oxycodone resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-4606-0597]
synonym: "enhanced behavioural response to oxycodone" EXACT []
is_a: MP:0021167 ! abnormal behavioral response to oxycodone
property_value: dc:date "2022-07-06T19:39:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021169
name: impaired behavioral response to oxycodone
def: "decreased sensitivity to oxycodone resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0003-4606-0597]
synonym: "impaired behavioural response to oxycodone" EXACT []
is_a: MP:0021167 ! abnormal behavioral response to oxycodone
property_value: dc:date "2022-07-06T19:40:09Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021170
name: spinal stenosis
def: "abnormal narrowing or constriction of the spaces within the vertebral column" [https://my.clevelandclinic.org/health/diseases/17499-spinal-stenosis]
synonym: "narrow spinal canal" EXACT []
synonym: "vertebral canal stenosis" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: dc:date "2022-07-06T19:48:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021171
name: abnormal granulocyte nuclear morphology
def: "any structural anomaly in the nucleus of granulocytes" [PMID:22338047]
is_a: MP:0002441 ! abnormal granulocyte morphology
is_a: MP:0003111 ! abnormal cell nucleus morphology
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021172
name: abnormal neutrophil nuclear morphology
def: "any structural anomaly in the nucleus of neutrophils" [PMID:22338047, PMID:30564248]
is_a: MP:0021171 ! abnormal granulocyte nuclear morphology
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021173
name: abnormal neutrophil nuclear segmentation
def: "any anomaly in the number or structure of the lobes of the nucleus of neutrophils" [PMID:22338047, PMID:30564248]
is_a: MP:0021172 ! abnormal neutrophil nuclear morphology
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021174
name: decreased neutrophil nuclear segmentation
def: "reduced number of lobes of the neutrophil nucleus" [PMID:22338047]
synonym: "hyposegmented neutrophil nuclei" EXACT []
synonym: "neutrophil nuclear hyposegmentation" EXACT []
is_a: MP:0021173 ! abnormal neutrophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021175
name: symmetrical hyposegmentation of neutrophil nuclei
def: "reduced number of lobes of the neutrophil nucleus and the remaining lobes have a symmetrical morphology" [PMID:22338047]
synonym: "Pelger-Huet anomaly" RELATED []
is_a: MP:0021174 ! decreased neutrophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021176
name: asymmetrical hyposegmentation of neutrophil nuclei
def: "reduced number of lobes of the neutrophil nucleus and the remaining lobes have an asymmetrical morphology" [PMID:22338047]
is_a: MP:0021174 ! decreased neutrophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021177
name: increased neutrophil nuclear segmentation
def: "elevated number of lobes of the neutrophil nucleus" [PMID:22338047]
synonym: "neutrophil nuclear hypersegmentation" EXACT []
is_a: MP:0021173 ! abnormal neutrophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021178
name: abnormal eosinophil nuclear morphology
def: "any structural anomaly in the nucleus of eosinophils" [PMID:22338047]
is_a: MP:0021171 ! abnormal granulocyte nuclear morphology
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021179
name: abnormal eosinophil nuclear segmentation
def: "any anomaly in the number or structure of the lobes of the nucleus of eosinophils" [PMID:22338047]
is_a: MP:0021178 ! abnormal eosinophil nuclear morphology
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021180
name: decreased eosinophil nuclear segmentation
def: "reduced number of lobes of the eosinophil nucleus" [PMID:22338047]
synonym: "eosinophil nuclear hyposegmentation" EXACT []
synonym: "Pelger-Huet anomaly" RELATED []
is_a: MP:0021179 ! abnormal eosinophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021181
name: increased eosinophil nuclear segmentation
def: "elevated number of lobes of the eosinophil nucleus" [PMID:22338047]
synonym: "eosinophil nuclear hypersegmentation" EXACT []
is_a: MP:0021179 ! abnormal eosinophil nuclear segmentation
property_value: terms:contributor https://orcid.org/0000-0002-5034-2637
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021182
name: decreased femoral compact bone area
def: "reduction in the total amount of cross-sectional area of compact bone tissue in the femur" [PMID:22446865]
synonym: "decreased compact bone area of femur" EXACT []
synonym: "decreased compact bone cross-sectional area of femur" EXACT []
synonym: "reduced femoral compact bone area" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0010968 ! decreased compact bone area
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021183
name: increased femoral compact bone area
def: "increase in the total amount of cross-sectional area of compact bone tissue in the femur" [PMID:22446865]
synonym: "increased compact bone area of femur" EXACT []
synonym: "increased compact bone cross-sectional area of femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
is_a: MP:0010967 ! increased compact bone area
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021184
name: decreased bone mineral density of humerus
def: "reduction in the quantitative measurement value of mineral content of bone in the upper bone of the forelimb" [PMID:22446865]
synonym: "decreased humerus bone mineral density" EXACT []
synonym: "reduced BMD of humerus" EXACT []
is_a: MP:0000063 ! decreased bone mineral density
is_a: MP:0005296 ! abnormal humerus morphology
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021185
name: increased bone mineral density of humerus
def: "elevation in the quantitative measurement value of mineral content of bone in the upper bone of the forelimb" [PMID:22446865]
synonym: "increased BMD of humerus" EXACT []
synonym: "increased humerus bone mineral density" EXACT []
is_a: MP:0000062 ! increased bone mineral density
is_a: MP:0005296 ! abnormal humerus morphology
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021186
name: decreased bone mineral density of vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments of the spinal column" [PMID:22446865]
synonym: "decreased vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of vertebrae" EXACT []
is_a: MP:0000063 ! decreased bone mineral density
is_a: MP:0000137 ! abnormal vertebrae morphology
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021187
name: increased bone mineral density of vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments of the spinal column" [PMID:22446865]
synonym: "increased BMD of vertebrae" EXACT []
synonym: "increased vertebrae bone mineral density" EXACT []
is_a: MP:0000062 ! increased bone mineral density
is_a: MP:0000137 ! abnormal vertebrae morphology
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021188
name: decreased bone mineral density of presacral vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located anterior to the sacrum" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased presacral vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of presacral vertebrae" EXACT []
is_a: MP:0000459 ! abnormal presacral vertebrae morphology
is_a: MP:0021186 ! decreased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021189
name: increased bone mineral density of presacral vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located anterior to the sacrum" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased BMD of presacral vertebrae" EXACT []
synonym: "increased presacral vertebrae bone mineral density" EXACT []
is_a: MP:0000459 ! abnormal presacral vertebrae morphology
is_a: MP:0021187 ! increased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021190
name: decreased bone mineral density of lumbar vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [PMID:22446865]
synonym: "decreased lumbar vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of lumbar vertebrae" EXACT []
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology
is_a: MP:0021188 ! decreased bone mineral density of presacral vertebrae
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021191
name: increased bone mineral density of lumbar vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [PMID:22446865]
synonym: "increased BMD of lumbar vertebrae" EXACT []
synonym: "increased lumbar vertebrae bone mineral density" EXACT []
is_a: MP:0003049 ! abnormal lumbar vertebrae morphology
is_a: MP:0021189 ! increased bone mineral density of presacral vertebrae
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021192
name: decreased bone mineral density of sacral vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased sacral vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of sacral vertebrae" EXACT []
is_a: MP:0003050 ! abnormal sacral vertebrae morphology
is_a: MP:0021186 ! decreased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021193
name: increased bone mineral density of sacral vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased BMD of sacral vertebrae" EXACT []
synonym: "increased sacral vertebrae bone mineral density" EXACT []
is_a: MP:0003050 ! abnormal sacral vertebrae morphology
is_a: MP:0021187 ! increased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021194
name: decreased bone mineral density of caudal vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments of the coccyx or tail" [PMID:8717536]
synonym: "decreased caudal vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of caudal vertebrae" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0021186 ! decreased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021195
name: increased bone mineral density of caudal vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments of the coccyx or tail" [PMID:8717536]
synonym: "increased BMD of caudal vertebrae" EXACT []
synonym: "increased caudal vertebrae bone mineral density" EXACT []
is_a: MP:0002759 ! abnormal caudal vertebrae morphology
is_a: MP:0021187 ! increased bone mineral density of vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021196
name: decreased bone mineral density of cervical vertebrae
def: "reduction in the quantitative measurement value of mineral content of bone in any of the bony segments located anterior to the thoracic vertebrae and caudal to the skull" [https://orcid.org/0000-0003-4606-0597]
synonym: "decreased cervical vertebrae bone mineral density" EXACT []
synonym: "reduced BMD of cervical vertebrae" EXACT []
is_a: MP:0003048 ! abnormal cervical vertebrae morphology
is_a: MP:0021188 ! decreased bone mineral density of presacral vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021197
name: increased bone mineral density of cervical vertebrae
def: "elevation in the quantitative measurement value of mineral content of bone in any of the bony segments located anterior to the thoracic vertebrae and caudal to the skull" [https://orcid.org/0000-0003-4606-0597]
synonym: "increased BMD of cervical vertebrae" EXACT []
synonym: "increased cervical vertebrae bone mineral density" EXACT []
is_a: MP:0003048 ! abnormal cervical vertebrae morphology
is_a: MP:0021189 ! increased bone mineral density of presacral vertebrae
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021198
name: abnormal sleep duration
def: "any anomaly in the amount of time spent asleep in a defined period of time" [PMID:17107938, PMID:28231463]
is_a: MP:0011396 ! abnormal sleep behavior
property_value: dc:date "2022-08-29T18:23:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021199
name: abnormal susceptibility to glomerulonephritis
def: "a change in the likelihood or extent of inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response" [PMID:20488952]
synonym: "abnormal susceptibility to glomerular nephritis" EXACT []
is_a: MP:0005325 ! abnormal renal glomerulus morphology
property_value: dc:date "2022-10-18T18:51:49Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021200
name: decreased susceptibility to glomerulonephritis
def: "a diminished likelihood or extent of inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response" [PMID:20488952]
synonym: "decreased susceptibility to glomerular nephritis" EXACT []
is_a: MP:0021199 ! abnormal susceptibility to glomerulonephritis
property_value: dc:date "2022-10-18T18:55:52Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803

[Term]
id: MP:0021201
name: increased susceptibility to glomerulonephritis
def: "an increased likelihood or extent of inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response" [PMID:20488952]
synonym: "increased susceptibility to glomerular nephritis" EXACT []
is_a: MP:0021199 ! abnormal susceptibility to glomerulonephritis
property_value: dc:date "2022-10-18T18:56:06Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597
property_value: terms:contributor https://orcid.org/0000-0003-3645-6803

[Term]
id: MP:0021202
name: abnormal palatopharyngeus muscle morphology
def: "any structural anomaly in the small muscle in the roof of the mouth that is a long, fleshy fasciculus that forms, with the mucous membrane covering its surface, the palatopharyngeal arch" [https://en.wikipedia.org/wiki/Palatopharyngeus_muscle]
synonym: "abnormal palatopharyngeal muscle morphology" EXACT []
synonym: "abnormal pharyngopalatinus muscle morphology" EXACT []
is_a: MP:0030224 ! abnormal soft palate muscle morphology
property_value: dc:date "2022-10-18T19:52:25Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021203
name: abnormal palatine aponeurosis morphology
def: "any structural anomaly in the thin, firm fibrous lamella attached to the posterior border of the hard palate that serves as the insertion point for the tensor veli palatini and levator veli palatini muscles and provides support for the soft palate" [http://purl.obolibrary.org/obo/UBERON_0014780]
is_a: MP:0003154 ! abnormal soft palate morphology
property_value: dc:date "2022-10-18T20:02:24Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021204
name: abnormal superior pharyngeal constrictor muscle morphology
def: "any structural anomaly in the uppermost of the pharyngeal constrictors and is a quadrilateral muscle that is thinner and paler than the middle and inferior pharyngeal constrictor muscles" [https://en.wikipedia.org/wiki/Superior_pharyngeal_constrictor_muscle]
synonym: "abnormal constrictor muscle of pharynx superior morphology" EXACT []
synonym: "abnormal morphology of the superior constrictor of pharynx" EXACT []
synonym: "abnormal musculus constrictor pharyngis superior morphology" EXACT []
synonym: "abnormal superior constrictor morphology" EXACT []
synonym: "abnormal superior constrictor pharyngeus morphology" EXACT []
is_a: MP:0002253 ! abnormal pharyngeal muscle morphology
property_value: dc:date "2022-10-18T20:10:22Z" xsd:dateTime
property_value: terms:contributor http://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021205
name: effusion
def: "an abnormal collection of fluid in cavities or between tissues in the body" [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/effusion]
is_a: MP:0001784 ! abnormal fluid regulation
property_value: dc:date "2022-11-15T19:37:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021206
name: abnormal limb muscle morphology
def: "any structural anomaly in the muscles that are part of a limb" [http://purl.obolibrary.org/obo/UBERON_0003661]
is_a: MP:0002109 ! abnormal limb morphology
is_a: MP:0003358 ! abnormal hypaxial muscle morphology
property_value: dc:date "2022-11-15T20:03:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021207
name: abnormal autopod muscle morphology
def: "any structural anomaly of the muscles of the autopod region" [http://purl.obolibrary.org/obo/UBERON_0006508]
synonym: "abnormal interosseous muscle of autopod morphology" EXACT []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0021206 ! abnormal limb muscle morphology
property_value: dc:date "2022-11-15T20:14:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021208
name: median cleft palate
def: "fissure along the midline of the palate" [] {comment="HP:0009099"}
synonym: "central cleft palate" EXACT []
synonym: "midline cleft palate" EXACT []
is_a: MP:0000111 ! cleft palate
property_value: dc:date "2022-11-16T16:01:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021209
name: non-midline cleft palate
def: "fissure of the palate that is not located along the midline" [http://purl.obolibrary.org/obo/HP_0100338, https://orcid.org/0000-0003-4606-0597]
synonym: "paramedian cleft palate" EXACT []
is_a: MP:0000111 ! cleft palate
property_value: dc:date "2022-11-16T16:07:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021210
name: bilateral cleft palate
def: "non-midline fissures of the palate on both the left and right sides" [http://purl.obolibrary.org/obo/HP_0100337, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0021209 ! non-midline cleft palate
property_value: dc:date "2022-11-16T16:11:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021211
name: unilateral cleft palate
def: "fissure of the palate located on either the left or right side but not both" [http://purl.obolibrary.org/obo/HP_0100334, https://orcid.org/0000-0003-4606-0597]
is_a: MP:0021209 ! non-midline cleft palate
property_value: dc:date "2022-11-16T16:11:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021212
name: abnormal primary and secondary palatal fusion
def: "any anomaly in the process by which the primary and secondary palates fuse to form the definite palate" [PMID:3074914, PMID:31171577]
is_a: MP:0009653 ! abnormal palate development
property_value: dc:date "2022-11-16T16:20:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021213
name: complete cleft palate
def: "fissure of the palate that involves the full length of both the primary and secondary palates" [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706041/]
is_a: MP:0000111 ! cleft palate
property_value: dc:date "2022-11-16T16:34:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021214
name: anterior cleft palate
def: "fissure of the palate formed by the failure of fusion between the primary and secondary palates" [PMID:31171577]
is_a: MP:0000111 ! cleft palate
property_value: dc:date "2022-11-16T16:42:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021215
name: abnormal palatal mesenchymal cell proliferation
def: "any anomaly in the ability of the cranial neural crest derived mesenchymal cells located in the palate to undergo expansion by cell division" [PMID:3074914]
is_a: MP:0009653 ! abnormal palate development
property_value: dc:date "2022-12-29T15:46:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021216
name: abnormal palatal mesenchymal cell differentiation
def: "atypical formation of or inability to produce the cranial neural crest derived mesenchymal cells located in the palate" [PMID:3074914]
is_a: MP:0009653 ! abnormal palate development
property_value: dc:date "2022-12-29T15:47:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0021217
name: abnormal palatal shelf bone ossification
def: "any anomaly in the ossification of the the osteogenic blastemata of the palatal processes of the maxillary and palatine bones formed in the mesenchyme of the hard palate" [PMID:3074914]
is_a: MP:0008273 ! abnormal intramembranous bone ossification
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: dc:date "2022-12-29T19:05:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597

[Term]
id: MP:0030000
name: abnormal subglottis morphology
def: "any structural anomaly of the lower portion of the larynx, extending from just beneath the vocal cords down to the top of the trachea; the structures in the subglottis are implicated in the regulation of the temperature of the breath" [https://en.wikipedia.org/wiki/Subglottis, ORCID:orcid.org/0000-0002-6490-7723]
synonym: "abnormal subglottic region" EXACT []
is_a: MP:0002249 ! abnormal larynx morphology

[Term]
id: MP:0030001
name: subglottis stenosis
def: "congenital or acquired narrowing or constriction of the subglottic airway, extending from just beneath the vocal cords down to the top of the trachea" [https://en.wikipedia.org/wiki/Subglottis, ORCID:orcid.org/0000-0002-6490-7723, PMID:23770197, PMID:25542773]
comment: Subglottic stenosis can present as a life-threatening airway emergency and may require tracheotomy.
synonym: "subglottic stenosis" EXACT []
is_a: MP:0012491 ! larynx stenosis
is_a: MP:0030000 ! abnormal subglottis morphology

[Term]
id: MP:0030002
name: increased lung apoptosis
def: "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
synonym: "increased pulmonary cell apoptosis" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0006042 ! increased apoptosis

[Term]
id: MP:0030003
name: hippocampus atrophy
def: "acquired diminution of the size of the hippocampus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic hippocampus" EXACT []
synonym: "hippocampal atrophy" EXACT []
is_a: MP:0008283 ! small hippocampus

[Term]
id: MP:0030004
name: hippocampus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the hippocampus, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hippocampal hypoplasia" EXACT []
synonym: "hypoplastic hippocampus" EXACT []
is_a: MP:0008283 ! small hippocampus
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-20T19:06:56Z" xsd:dateTime

[Term]
id: MP:0030005
name: increased retina apoptosis
def: "increase in the number of cells in the retina undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased retinal apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0006072 ! abnormal retina apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-20T19:59:17Z" xsd:dateTime

[Term]
id: MP:0030006
name: decreased retina apoptosis
def: "decrease in the number of cells in the retina undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased retinal apoptosis" EXACT []
synonym: "reduced retina apoptosis" EXACT []
synonym: "reduced retinal apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0006072 ! abnormal retina apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-20T20:06:09Z" xsd:dateTime

[Term]
id: MP:0030007
name: abnormal bone marrow adipose tissue morphology
def: "any structural anomaly of the functionally distinct adipose depot that is located within the skeleton and has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases" [PMID:27094502]
synonym: "abnormal marrow adipose tissue morphology" EXACT []
synonym: "abnormal MAT morphology" EXACT []
is_a: MP:0000003 ! abnormal adipose tissue morphology
is_a: MP:0002397 ! abnormal bone marrow morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-21T19:05:42Z" xsd:dateTime

[Term]
id: MP:0030008
name: abnormal bone marrow adipose tissue amount
def: "anomaly in the quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]
synonym: "abnormal marrow adipose tissue amount" EXACT []
synonym: "abnormal marrow fat amount" EXACT []
synonym: "abnormal MAT amount" EXACT []
is_a: MP:0030007 ! abnormal bone marrow adipose tissue morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-21T19:20:32Z" xsd:dateTime

[Term]
id: MP:0030009
name: increased bone marrow adipose tissue amount
def: "increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]
synonym: "increased bone marrow adiposity" EXACT []
synonym: "increased bone marrow fat" EXACT []
synonym: "increased bone marrow fat amount" EXACT []
synonym: "increased marrow fat" EXACT []
synonym: "marrow adipose tissue expansion" EXACT []
synonym: "MAT expansion" EXACT []
is_a: MP:0030008 ! abnormal bone marrow adipose tissue amount
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-21T20:06:57Z" xsd:dateTime

[Term]
id: MP:0030011
name: small cervical lymph nodes
def: "reduced size of the lymph nodes found near the neck and shoulders" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cervical lymph node size" EXACT []
synonym: "reduced cervical lymph node size" EXACT []
is_a: MP:0002217 ! small lymph nodes
is_a: MP:0002351 ! abnormal cervical lymph node morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-23T17:13:52Z" xsd:dateTime

[Term]
id: MP:0030012
name: impaired central nervous system regeneration
def: "decrease in the renewal, repair, and/or regrowth of central nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased central nervous system regeneration" EXACT []
synonym: "decreased CNS regeneration" EXACT []
synonym: "impaired CNS regeneration" EXACT []
synonym: "reduced central nervous system regeneration" EXACT []
synonym: "reduced CNS regeneration" EXACT []
is_a: MP:0003407 ! abnormal central nervous system regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-23T17:52:31Z" xsd:dateTime

[Term]
id: MP:0030013
name: enhanced central nervous system regeneration
def: "increase in the renewal, repair, and/or regrowth of central nervous system tissue following injury or disease" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "enhanced CNS regeneration" EXACT []
synonym: "improved central nervous system regeneration" EXACT []
synonym: "improved CNS regeneration" EXACT []
synonym: "increased central nervous system regeneration" EXACT []
synonym: "increased CNS regeneration" EXACT []
is_a: MP:0003407 ! abnormal central nervous system regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-23T18:29:36Z" xsd:dateTime

[Term]
id: MP:0030014
name: calcified brain
def: "pathologic deposition of calcium salts in the brain" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "brain calcification" BROAD []
is_a: MP:0002152 ! abnormal brain morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-06-26T13:39:58Z" xsd:dateTime

[Term]
id: MP:0030016
name: increased adipocyte glucose uptake
def: "increased ability of adipocytes to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced adipocyte glucose uptake" EXACT []
synonym: "enhanced fat cell glucose uptake" EXACT []
synonym: "improved adipocyte glucose uptake" EXACT []
synonym: "improved fat cell glucose uptake" EXACT []
synonym: "increased fat cell glucose uptake" EXACT []
is_a: MP:0003927 ! increased cellular glucose import
is_a: MP:0004185 ! abnormal adipocyte glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T08:04:29Z" xsd:dateTime

[Term]
id: MP:0030017
name: decreased adipocyte glucose uptake
def: "reduced ability of adipocytes to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased fat cell glucose uptake" EXACT []
synonym: "impaired adipocyte glucose uptake" EXACT []
synonym: "impaired fat cell glucose uptake" EXACT []
synonym: "reduced adipocyte glucose uptake" EXACT []
synonym: "reduced fat cell glucose uptake" EXACT []
is_a: MP:0003926 ! decreased cellular glucose uptake
is_a: MP:0004185 ! abnormal adipocyte glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T08:57:27Z" xsd:dateTime

[Term]
id: MP:0030018
name: increased cardiac muscle cell glucose uptake
def: "increased ability of the cells of the heart muscle to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced cardiac cell glucose uptake" EXACT []
synonym: "enhanced heart cell glucose uptake" EXACT []
synonym: "improved cardiac cell glucose uptake" EXACT []
synonym: "improved heart cell glucose uptake" EXACT []
synonym: "increased heart cell glucose uptake" EXACT []
is_a: MP:0004039 ! abnormal cardiac muscle cell glucose uptake
is_a: MP:0030021 ! increased muscle cell glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T09:51:02Z" xsd:dateTime

[Term]
id: MP:0030020
name: decreased cardiac muscle cell glucose uptake
def: "reduced ability of the cells of the heart muscle to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased heart cell glucose uptake" EXACT []
synonym: "impaired cardiac cell glucose uptake" EXACT []
synonym: "impaired heart cell glucose uptake" EXACT []
synonym: "reduced cardiac cell glucose uptake" EXACT []
synonym: "reduced heart cell glucose uptake" EXACT []
is_a: MP:0004039 ! abnormal cardiac muscle cell glucose uptake
is_a: MP:0030022 ! decreased muscle cell glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T10:14:56Z" xsd:dateTime

[Term]
id: MP:0030021
name: increased muscle cell glucose uptake
def: "increased ability of muscle cells to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced muscle cell glucose uptake" EXACT []
synonym: "improved muscle cell glucose uptake" EXACT []
is_a: MP:0003927 ! increased cellular glucose import
is_a: MP:0004130 ! abnormal muscle cell glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T10:36:13Z" xsd:dateTime

[Term]
id: MP:0030022
name: decreased muscle cell glucose uptake
def: "reduced ability of muscle cells to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired muscle cell glucose uptake" EXACT []
synonym: "reduced muscle cell glucose uptake" EXACT []
is_a: MP:0003926 ! decreased cellular glucose uptake
is_a: MP:0004130 ! abnormal muscle cell glucose uptake
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-10T10:42:14Z" xsd:dateTime

[Term]
id: MP:0030023
name: abnormal meiotic telomere clustering
def: "any anomaly in the cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body; this process plays an important role in progression through meiosis and precedes synapsis" []
synonym: "abnormal meiotic bouquet biosynthesis" NARROW []
synonym: "abnormal meiotic bouquet formation" NARROW []
xref: GO:0045141
xref: PMID:1754386
is_a: MP:0001930 ! abnormal meiosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-11T08:54:55Z" xsd:dateTime

[Term]
id: MP:0030024
name: abnormal meiotic attachment of telomere to nuclear envelope
def: "any anomaly in the meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation" [GO:0070197]
synonym: "abnormal attachment of telomeres to nuclear envelope" BROAD []
synonym: "abnormal attachment of telomeric chromatin to nuclear envelope" BROAD []
synonym: "abnormal attachment of telomeric heterochromatin to nuclear envelope" EXACT []
is_a: MP:0030023 ! abnormal meiotic telomere clustering
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-11T10:41:43Z" xsd:dateTime

[Term]
id: MP:0030025
name: giant platelets
def: "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
is_a: MP:0002599 ! increased mean platelet volume
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-13T09:54:05Z" xsd:dateTime

[Term]
id: MP:0030026
name: small Meckel's cartilage
def: "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular cartilage size" EXACT []
synonym: "decreased Meckel cartilage size" EXACT []
synonym: "decreased Meckel's cartilage size" EXACT []
synonym: "reduced Meckel cartilage size" EXACT []
synonym: "reduced Meckel's cartilage size" EXACT []
synonym: "small mandibular cartilage" EXACT []
synonym: "small Meckel cartilage" EXACT []
is_a: MP:0005587 ! abnormal Meckel's cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T13:16:47Z" xsd:dateTime

[Term]
id: MP:0030027
name: basioccipital bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the basioccipital bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased basioccipital bone cellularity" RELATED []
synonym: "hypoplastic basioccipital bone" EXACT []
is_a: MP:0004447 ! small basioccipital bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T14:11:52Z" xsd:dateTime

[Term]
id: MP:0030028
name: absent exoccipital bone
def: "absence of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing exoccipital bone" RELATED []
is_a: MP:0000080 ! abnormal exoccipital bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T14:39:23Z" xsd:dateTime

[Term]
id: MP:0030029
name: wide cranial sutures
def: "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
synonym: "broad cranial sutures" EXACT []
synonym: "large cranial sutures" EXACT []
synonym: "open cranial sutures" EXACT []
synonym: "persistent open cranial sutures" EXACT []
synonym: "wide spaced cranial sutures" EXACT []
synonym: "widened cranial sutures" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T14:51:39Z" xsd:dateTime

[Term]
id: MP:0030030
name: Wormian bones
def: "presence of small extra bone segments, usually of irregular shape and variable size, arising in fontanelles and/or adjacent to or along the cranial sutures, and formed from additional and separate centers of ossification of the cranium; in humans, Wormian bones are most frequently located in the lambdoid or coronal suture, and have been seen in the fontanelles, particularly the posterior fontanelle" [https://www.kenhub.com/en/library/anatomy/accessory-bones-of-the-skull, PMID:23959948]
synonym: "accessory skull bones" BROAD []
synonym: "extra bones within cranial sutures" EXACT []
synonym: "intra sutural bones" EXACT []
synonym: "intrasutural bones" EXACT []
synonym: "islands of bone within cranial sutures or fontanelles" EXACT []
synonym: "supernumerary skull bones" BROAD []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T15:07:20Z" xsd:dateTime

[Term]
id: MP:0030031
name: abnormal forehead morphology
def: "any structural anomaly of the part of the face above the eyes; in human anatomy, the forehead is the fore part of the head, an area of the head bounded by three features, two of the skull and one of the scalp; the top of the forehead is marked by the hairline, the edge of the area where hair on the scalp grows while the bottom of the forehead is marked by the supraorbital ridge, the bone feature of the skull above the eyes; the two sides of the forehead are marked by the temporal ridge, a bone feature that links the supraorbital ridge to the coronal suture line and beyond" [HP:0000290]
synonym: "abnormality of the frontal region of the face" BROAD []
synonym: "deformity of the forehead" NARROW []
synonym: "forehead anomaly" NARROW []
synonym: "malformation of the forehead" NARROW []
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T15:36:30Z" xsd:dateTime

[Term]
id: MP:0030032
name: high forehead
def: "an abnormally increased height of the forehead" [HP:0000348]
synonym: "tall forehead" RELATED []
is_a: MP:0030042 ! large forehead
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-07-24T16:07:55Z" xsd:dateTime

[Term]
id: MP:0030033
name: abnormal nasal bridge morphology
def: "any structural anomaly of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose; it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [HP:0000422]
synonym: "nasal bridge malformation" NARROW []
is_a: MP:0000443 ! abnormal snout morphology
is_a: MP:0002233 ! abnormal nose morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T07:41:13Z" xsd:dateTime

[Term]
id: MP:0030034
name: depressed nasal bridge
def: "posterior positioning of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose in relation to the overall facial profile for age; normally, it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [HP:0005280]
synonym: "concave bridge of nose" RELATED []
synonym: "concave nasal bridge" RELATED []
synonym: "depressed bridge of nose" EXACT []
synonym: "depressed nasal root" EXACT []
synonym: "depressed nasal root/bridge" RELATED []
synonym: "flat bridge of nose" EXACT []
synonym: "flat nasal bridge" EXACT []
synonym: "flat nasal root" EXACT []
synonym: "flattened nasal bridge" EXACT []
synonym: "low nasal bridge" EXACT []
synonym: "low nasal root" EXACT []
synonym: "retruded bridge of nose" EXACT []
synonym: "retruded nasal bridge" EXACT []
is_a: MP:0030033 ! abnormal nasal bridge morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T08:47:17Z" xsd:dateTime

[Term]
id: MP:0030035
name: small nasal bridge
def: "reduced size of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose; it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nasal bridge size" EXACT []
synonym: "reduced nasal bridge size" EXACT []
is_a: MP:0030033 ! abnormal nasal bridge morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T08:49:05Z" xsd:dateTime

[Term]
id: MP:0030036
name: short nasal bridge
def: "reduced length of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose; it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nasal bridge length" EXACT []
synonym: "reduced nasal bridge length" EXACT []
synonym: "shortened nasal bridge" EXACT []
is_a: MP:0030035 ! small nasal bridge
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T09:21:45Z" xsd:dateTime

[Term]
id: MP:0030037
name: prominent nasal bridge
def: "anterior positioning of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose in comparison to the usual positioning for age" [HP:0000426]
synonym: "convex bridge of nose" RELATED []
synonym: "convex nasal bridge" RELATED []
synonym: "elevated nasal bridge" EXACT []
synonym: "high nasal bridge" EXACT []
synonym: "prominent bridge of nose" EXACT []
synonym: "prominent nasal root" EXACT []
synonym: "protruding bridge of nose" EXACT []
synonym: "protruding nasal bridge" EXACT []
is_a: MP:0030033 ! abnormal nasal bridge morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T09:51:33Z" xsd:dateTime

[Term]
id: MP:0030038
name: abnormal periorbital region morphology
def: "any structural anomaly of the region around the eye socket" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal periorbital area morphology" EXACT []
synonym: "abnormal periorbital region" EXACT []
synonym: "periorbital region malformation" NARROW []
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T10:13:56Z" xsd:dateTime

[Term]
id: MP:0030039
name: abnormal facial muscle morphology
def: "any structural anomaly of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression; facial muscles are derived from the second branchial/pharyngeal arch" [https://en.wikipedia.org/wiki/Facial_muscles]
synonym: "abnormal facial musculature morphology" EXACT []
synonym: "facial muscle abnormalities" BROAD []
synonym: "facial muscle dysplasia" NARROW []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T10:57:47Z" xsd:dateTime

[Term]
id: MP:0030040
name: absent facial muscle
def: "absence of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression; facial muscles are derived from the second branchial/pharyngeal arch" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing facial muscle" EXACT []
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-08-29T11:13:23Z" xsd:dateTime

[Term]
id: MP:0030041
name: abnormal forehead size
def: "deviation from the average range of forehead size for an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "forehead size abnormalities" EXACT []
is_a: MP:0030031 ! abnormal forehead morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T11:41:07Z" xsd:dateTime

[Term]
id: MP:0030042
name: large forehead
def: "presence of an abnormally large forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged forehead" EXACT []
synonym: "increased forehead size" EXACT []
is_a: MP:0030041 ! abnormal forehead size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T12:05:29Z" xsd:dateTime

[Term]
id: MP:0030043
name: small forehead
def: "presence of an abnormally small forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased forehead size" EXACT []
synonym: "reduced forehead size" EXACT []
is_a: MP:0030041 ! abnormal forehead size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T12:28:46Z" xsd:dateTime

[Term]
id: MP:0030044
name: short forehead
def: "an abnormally decreased height of the forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased forehead height" EXACT []
synonym: "reduced forehead height" EXACT []
synonym: "shortened forehead" EXACT []
is_a: MP:0030043 ! small forehead
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T12:58:55Z" xsd:dateTime

[Term]
id: MP:0030045
name: abnormal forehead shape
def: "any anomaly in the characteristic surface outline or contour of the forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "forehead shape abnormalities" BROAD []
is_a: MP:0030031 ! abnormal forehead morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T13:06:02Z" xsd:dateTime

[Term]
id: MP:0030046
name: round forehead
def: "forehead appearance is more circular than usual as viewed from the front" [https://orcid.org/0000-0002-6490-7723]
synonym: "round forehead appearance" EXACT []
synonym: "round forehead shape" EXACT []
synonym: "rounded forehead" EXACT []
is_a: MP:0030045 ! abnormal forehead shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T13:14:39Z" xsd:dateTime

[Term]
id: MP:0030047
name: flat forehead
def: "abnormal flatness of the forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "flattened forehead" EXACT []
synonym: "frontal flattening" EXACT []
is_a: MP:0030045 ! abnormal forehead shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T13:33:53Z" xsd:dateTime

[Term]
id: MP:0030048
name: sloping forehead
def: "apparently excessive posterior sloping of the forehead in a lateral view" [HP:0000340]
synonym: "inclined forehead" EXACT []
synonym: "posteriorly sloping forehead" EXACT []
synonym: "receding forehead" EXACT []
is_a: MP:0030045 ! abnormal forehead shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T13:49:10Z" xsd:dateTime

[Term]
id: MP:0030049
name: prominent forehead
def: "forward prominence of the entire forehead, due to protrusion of the frontal bone; not to be confused with frontal bossing" [HP:0011220]
synonym: "bulging forehead" RELATED []
synonym: "prominence of the frontal region" EXACT []
synonym: "pronounced forehead" EXACT []
synonym: "protruding forehead" EXACT []
synonym: "protuberant forehead" EXACT []
is_a: MP:0030045 ! abnormal forehead shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T13:55:37Z" xsd:dateTime

[Term]
id: MP:0030050
name: large mandible
def: "increased size of the lower bony framework of the mouth where the inferior teeth are held" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged lower jaw" EXACT []
synonym: "enlarged mandible" EXACT []
synonym: "increased mandible size" EXACT []
synonym: "increased mandibular size" EXACT []
synonym: "large lower jaw" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T14:17:15Z" xsd:dateTime

[Term]
id: MP:0030051
name: increased foot pigmentation
def: "darker color of the foot surface due to excess pigment" [https://orcid.org/0000-0002-6490-7723]
synonym: "dark feet" EXACT []
synonym: "foot hyperpigmentation" EXACT []
is_a: MP:0001188 ! hyperpigmentation
is_a: MP:0009379 ! abnormal foot pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T14:46:39Z" xsd:dateTime

[Term]
id: MP:0030052
name: abnormal forehead pigmentation
def: "anomaly in the coloration of the skin of the forehead due to changes in the amount, shape, or distribution of cells producing pigment" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002095 ! abnormal skin pigmentation
is_a: MP:0030534 ! abnormal forehead skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T15:12:44Z" xsd:dateTime

[Term]
id: MP:0030053
name: increased forehead pigmentation
def: "visually detectable excess of pigment present in the forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "darkening of the forehead" EXACT []
synonym: "forehead hyperpigmentation" EXACT []
is_a: MP:0001188 ! hyperpigmentation
is_a: MP:0030052 ! abnormal forehead pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T15:34:01Z" xsd:dateTime

[Term]
id: MP:0030054
name: decreased forehead pigmentation
def: "visually detectable dilution of pigment present in the forehead" [https://orcid.org/0000-0002-6490-7723]
synonym: "forehead hypopigmentation" EXACT []
synonym: "reduced forehead pigmentation" EXACT []
is_a: MP:0011627 ! decreased skin pigmentation
is_a: MP:0030052 ! abnormal forehead pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T16:12:14Z" xsd:dateTime

[Term]
id: MP:0030055
name: small lacrimal bone
def: "reduced size of the thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "decreased lacrimal bone size" EXACT []
synonym: "reduced lacrimal bone size" EXACT []
is_a: MP:0005271 ! abnormal lacrimal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T16:37:00Z" xsd:dateTime

[Term]
id: MP:0030056
name: lacrimal bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lacrimal bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic lacrimal bone" EXACT []
is_a: MP:0030055 ! small lacrimal bone
is_a: MP:0030386 ! facial bone hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T16:43:53Z" xsd:dateTime

[Term]
id: MP:0030057
name: absent lacrimal bone
def: "absence of the thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing lacrimal bone" EXACT []
is_a: MP:0005271 ! abnormal lacrimal bone morphology
is_a: MP:0030385 ! absent facial bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T16:47:19Z" xsd:dateTime

[Term]
id: MP:0030058
name: erythrodontia
def: "reddish, brown opalescent discoloration of teeth in normal light" [HP:0030756]
synonym: "red teeth" EXACT []
is_a: MP:0013129 ! abnormal tooth color
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T17:05:24Z" xsd:dateTime

[Term]
id: MP:0030059
name: absent ethmoturbinates
def: "absence of the conchae of the ethmoid bone which normally occupy the caudal part of the nasal fossae and form the lateral and superior portions of the turbinate bones in mammals" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent ethmoturbinals" EXACT []
is_a: MP:0008971 ! abnormal ethmoturbinate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T17:38:32Z" xsd:dateTime

[Term]
id: MP:0030060
name: absent nasal pit
def: "absence of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus; the nasal pits indent the frontonasal process and divide it into a medial and two lateral nasal processes" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent olfactory pit" EXACT []
synonym: "missing nasal pit" EXACT []
synonym: "missing olfactory pit" EXACT []
is_a: MP:0006306 ! abnormal nasal pit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T18:13:48Z" xsd:dateTime

[Term]
id: MP:0030061
name: absent otic pit
def: "absence of the paired depression of thickened otic placode epithelium marking the location of the future otic vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent auditory pit" EXACT []
synonym: "absent otic cup" EXACT []
is_a: MP:0011172 ! abnormal otic pit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T18:24:14Z" xsd:dateTime

[Term]
id: MP:0030062
name: choanal stenosis
def: "abnormal narrowing or constriction of either of the pair of posterior apertures of the nasal cavity that open into the nasopharynx" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow choanae" EXACT []
synonym: "narrow internal nares" EXACT []
synonym: "narrow posterior nares" EXACT []
synonym: "narrowed choanae" EXACT []
is_a: MP:0002236 ! abnormal internal nares morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-07T18:40:35Z" xsd:dateTime

[Term]
id: MP:0030063
name: abnormal face size
def: "deviation from the average range of face size for an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal facial size" EXACT []
synonym: "face size abnormalities" EXACT []
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T05:53:02Z" xsd:dateTime

[Term]
id: MP:0030064
name: small face
def: "presence of an abnormally small face" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased face size" EXACT []
synonym: "microface" EXACT []
synonym: "microfaces" EXACT []
synonym: "reduced face size" EXACT []
synonym: "short and narrow face" EXACT []
synonym: "small faces" EXACT []
is_a: MP:0030063 ! abnormal face size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T06:00:07Z" xsd:dateTime

[Term]
id: MP:0030065
name: face hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the face, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "facial hypoplasia" EXACT []
synonym: "hypoplastic face" EXACT []
is_a: MP:0030064 ! small face
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T06:10:00Z" xsd:dateTime

[Term]
id: MP:0030066
name: short face
def: "an abnormally decreased height (length) of the face" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased face height" EXACT []
synonym: "decreased face length" EXACT []
synonym: "decreased vertical dimension of the face" EXACT []
synonym: "reduced face height" EXACT []
synonym: "reduced face length" EXACT []
synonym: "short faces" EXACT []
synonym: "shortened face" EXACT []
synonym: "shortened faces" EXACT []
synonym: "vertical shortening of the face" EXACT []
is_a: MP:0030064 ! small face
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T06:32:34Z" xsd:dateTime

[Term]
id: MP:0030067
name: narrow face
def: "a reduction in the width of the upper and lower face" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased face breadth" EXACT []
synonym: "decreased face width" EXACT []
synonym: "decreased horizontal dimension of the face" EXACT []
synonym: "decreased transverse dimension of the face" EXACT []
synonym: "narrow faces" EXACT []
synonym: "reduced face breadth" EXACT []
synonym: "reduced face width" EXACT []
synonym: "thin face" RELATED []
synonym: "thin faces" RELATED []
is_a: MP:0030064 ! small face
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T06:43:38Z" xsd:dateTime

[Term]
id: MP:0030068
name: large face
def: "presence of an abnormally large face" [https://orcid.org/0000-0002-6490-7723]
synonym: "big face" EXACT []
synonym: "big faces" EXACT []
synonym: "enlarged face" EXACT []
synonym: "enlarged faces" EXACT []
synonym: "increased face size" EXACT []
synonym: "increased facial size" EXACT []
synonym: "large faces" EXACT []
is_a: MP:0030063 ! abnormal face size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T07:09:29Z" xsd:dateTime

[Term]
id: MP:0030069
name: broad face
def: "increased width of the upper and lower face" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad faces" EXACT []
synonym: "increased face breadth" EXACT []
synonym: "increased face width" EXACT []
synonym: "increased facial breadth" EXACT []
synonym: "increased facial width" EXACT []
synonym: "increased horizontal dimension of the face" EXACT []
synonym: "increased transverse dimension of the face" EXACT []
synonym: "wide face" EXACT []
synonym: "wide faces" EXACT []
is_a: MP:0030068 ! large face
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T07:14:00Z" xsd:dateTime

[Term]
id: MP:0030070
name: long face
def: "an abnormally increased height (length) of the face" [https://orcid.org/0000-0002-6490-7723]
synonym: "elongated face" EXACT []
synonym: "face elongation" EXACT []
synonym: "facial elongation" EXACT []
synonym: "increased face height" EXACT []
synonym: "increased face length" EXACT []
synonym: "increased facial height" EXACT []
synonym: "increased facial length" EXACT []
synonym: "increased vertical dimension of the face" EXACT []
synonym: "vertical elongation of the face" EXACT []
is_a: MP:0030068 ! large face
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T07:19:45Z" xsd:dateTime

[Term]
id: MP:0030071
name: abnormal face shape
def: "any anomaly in the characteristic surface outline or contour of the face" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal facial shape" EXACT []
synonym: "face shape abnormalities" EXACT []
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T07:27:58Z" xsd:dateTime

[Term]
id: MP:0030072
name: round face
def: "facial appearance is more circular than usual as viewed from the front" [HP:0000311]
synonym: "circular face" EXACT []
synonym: "circular faces" EXACT []
synonym: "round face shape" EXACT []
synonym: "round faces" EXACT []
synonym: "round facial appearance" EXACT []
synonym: "round facial shape" EXACT []
synonym: "rounded face" EXACT []
synonym: "rounded faces" EXACT []
is_a: MP:0030071 ! abnormal face shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T08:00:29Z" xsd:dateTime

[Term]
id: MP:0030073
name: square face
def: "facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance" [HP:0000321]
synonym: "square face shape" EXACT []
synonym: "square faces" EXACT []
synonym: "square facial shape" EXACT []
is_a: MP:0030071 ! abnormal face shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T08:11:11Z" xsd:dateTime

[Term]
id: MP:0030074
name: coarse facial features
def: "absence of fine and sharp appearance of facial features, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues" [HP:0000280]
synonym: "coarse face" EXACT []
synonym: "coarse faces" EXACT []
synonym: "coarse facial appearance" EXACT []
is_a: MP:0030071 ! abnormal face shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-08T08:26:00Z" xsd:dateTime

[Term]
id: MP:0030075
name: hairy ears
def: "excessive hair growth on the external ear; may involve the meatal opening, pinnae or external rim" [https://orcid.org/0000-0002-6490-7723]
synonym: "auricular hypertrichosis" EXACT []
synonym: "ear hypertrichosis" EXACT []
synonym: "hairy pinna" EXACT []
is_a: MP:0000412 ! excessive hair
is_a: MP:0002177 ! abnormal outer ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T06:28:13Z" xsd:dateTime

[Term]
id: MP:0030076
name: abnormal cranial cavity morphology
def: "any anomaly of the space formed within the skull and occupied by the brain, pineal and hypophysis cerebri, parts of the cranial and spinal nerves, blood vessels, meninges and cerebrospinal fluid" [http://welovelmc.com/uncategorised/cranialcavity.htm, https://en.wikipedia.org/wiki/Cranial_cavity]
synonym: "abnormal intracranial cavity morphology" EXACT []
synonym: "abnormal intracranial space morphology" EXACT []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T07:34:43Z" xsd:dateTime

[Term]
id: MP:0030077
name: small cranial cavity
def: "reduced size of the space formed within the skull and occupied by the brain, pineal and hypophysis cerebri, parts of the cranial and spinal nerves, blood vessels, meninges and cerebrospinal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cranial cavity size" EXACT []
synonym: "decreased intracranial cavity size" EXACT []
synonym: "decreased intracranial space size" EXACT []
synonym: "reduced cranial cavity size" EXACT []
synonym: "reduced intracranial cavity size" EXACT []
synonym: "reduced intracranial space size" EXACT []
synonym: "small intracranial cavity" EXACT []
synonym: "small intracranial space" EXACT []
is_a: MP:0030076 ! abnormal cranial cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T07:44:49Z" xsd:dateTime

[Term]
id: MP:0030078
name: synotia
def: "fusion or abnormal approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw" [HP:0100663]
synonym: "auricular fusion" BROAD []
synonym: "fused ears" BROAD []
synonym: "fusion of external ears" BROAD []
is_a: MP:0000023 ! abnormal ear position
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T08:09:15Z" xsd:dateTime

[Term]
id: MP:0030079
name: small incisors
def: "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased incisor size" EXACT []
synonym: "incisor microdontia" EXACT []
synonym: "reduced incisor size" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0030088 ! microdontia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T09:21:56Z" xsd:dateTime

[Term]
id: MP:0030080
name: small lower incisors
def: "reduced size of the lower set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lower incisor size" EXACT []
synonym: "decreased mandibular incisor size" EXACT []
synonym: "reduced lower incisor size" EXACT []
synonym: "reduced mandibular incisor size" EXACT []
synonym: "small mandibular incisors" EXACT []
is_a: MP:0030079 ! small incisors
is_a: MP:0030136 ! abnormal lower incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T09:31:43Z" xsd:dateTime

[Term]
id: MP:0030081
name: small upper incisors
def: "reduced size of the upper set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased maxillary incisor size" EXACT []
synonym: "decreased upper incisor size" EXACT []
synonym: "reduced maxillary incisor size" EXACT []
synonym: "reduced upper incisor size" EXACT []
synonym: "small maxillary incisors" EXACT []
is_a: MP:0030079 ! small incisors
is_a: MP:0030137 ! abnormal upper incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T09:42:04Z" xsd:dateTime

[Term]
id: MP:0030082
name: long lower incisors
def: "increased length or overgrowth of the lower set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased lower incisor length" EXACT []
synonym: "increased mandibular incisor length" EXACT []
synonym: "long mandibular incisors" EXACT []
synonym: "overgrown lower incisors" EXACT []
synonym: "overgrown mandibular incisors" EXACT []
is_a: MP:0004831 ! long incisors
is_a: MP:0030136 ! abnormal lower incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T09:56:17Z" xsd:dateTime

[Term]
id: MP:0030083
name: long upper incisors
def: "increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased maxillary incisor length" EXACT []
synonym: "increased upper incisor length" EXACT []
synonym: "long maxillary incisors" EXACT []
synonym: "overgrown maxillary incisors" EXACT []
synonym: "overgrown upper incisors" EXACT []
is_a: MP:0004831 ! long incisors
is_a: MP:0030137 ! abnormal upper incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T10:03:25Z" xsd:dateTime

[Term]
id: MP:0030084
name: tympanic ring hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the tympanic ring, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic tympanic ring" EXACT []
is_a: MP:0006020 ! decreased tympanic ring size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T10:24:48Z" xsd:dateTime

[Term]
id: MP:0030085
name: syngnathia
def: "fusion of the upper and lower jaw; fusion can range from simple mucosal bands (synechiae) to complete bony fusion (synostosis); syngnathia can occur in the midline, or laterally, and it can be uni- or bilateral" [https://doi.org/10.1016/j.pedneo.2013.04.009, PMID:24385915]
synonym: "fusion of the maxilla and mandible" EXACT []
synonym: "maxillomandibular fusion" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T10:41:00Z" xsd:dateTime

[Term]
id: MP:0030086
name: bony syngnathia
def: "bony fusion of the upper and lower jaw" [https://doi.org/10.1016/j.pedneo.2013.04.009, PMID:24385915]
synonym: "bony fusion of the jaws" EXACT []
synonym: "bony fusion of the maxilla and mandible" EXACT []
synonym: "bony maxillomandibular fusion" EXACT []
synonym: "maxillomandibular synostosis" EXACT []
synonym: "synostosis of the jaws" EXACT []
is_a: MP:0030085 ! syngnathia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T10:50:08Z" xsd:dateTime

[Term]
id: MP:0030087
name: fibrous syngnathia
def: "complete or nearly complete soft tissue fusion of the alveolar ridges" [HP:0009754]
synonym: "alveolar synechiae" EXACT []
synonym: "fibrous fusion of the jaws" EXACT []
synonym: "fibrous maxillomandibular fusion" EXACT []
synonym: "fusion of the alveolar ridges" EXACT []
is_a: MP:0030085 ! syngnathia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T10:57:08Z" xsd:dateTime

[Term]
id: MP:0030088
name: microdontia
def: "abnormal reduction in the size of one or more teeth" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased tooth size" EXACT []
synonym: "decreased tooth width" NARROW []
synonym: "microdont" EXACT []
synonym: "microdontism" EXACT []
synonym: "reduced tooth size" EXACT []
synonym: "reduced tooth width" NARROW []
synonym: "small teeth" EXACT []
synonym: "small tooth" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T11:28:03Z" xsd:dateTime

[Term]
id: MP:0030089
name: short lower incisors
def: "reduced length of the lower set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lower incisor length" EXACT []
synonym: "decreased mandibular incisor length" EXACT []
synonym: "reduced lower incisor length" EXACT []
synonym: "reduced mandibular incisor length" EXACT []
synonym: "short mandibular incisors" EXACT []
is_a: MP:0004830 ! short incisors
is_a: MP:0030080 ! small lower incisors
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T11:52:55Z" xsd:dateTime

[Term]
id: MP:0030090
name: short upper incisors
def: "reduced length of the upper set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased maxillary incisor length" EXACT []
synonym: "decreased upper incisor length" EXACT []
synonym: "reduced maxillary incisor length" EXACT []
synonym: "reduced upper incisor length" EXACT []
synonym: "short maxillary incisors" EXACT []
is_a: MP:0004830 ! short incisors
is_a: MP:0030081 ! small upper incisors
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T12:07:08Z" xsd:dateTime

[Term]
id: MP:0030091
name: macrodontia
def: "abnormal increase in the size of one or more teeth" [HP:0001572, https://orcid.org/0000-0002-6490-7723]
synonym: "increased tooth size" EXACT []
synonym: "increased tooth width" NARROW []
synonym: "large teeth" EXACT []
synonym: "large tooth" EXACT []
synonym: "macrodont" EXACT []
synonym: "megadontia" EXACT []
synonym: "megadontism" EXACT []
synonym: "megalodontia" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T12:28:08Z" xsd:dateTime

[Term]
id: MP:0030092
name: abnormal outer ear helix morphology
def: "any structural anomaly of the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe" [HP:0011039]
synonym: "abnormal outer ear helices" EXACT []
synonym: "abnormal outer ear helix" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T12:51:04Z" xsd:dateTime

[Term]
id: MP:0030093
name: absent maxillary sinus
def: "absence of the largest of the paranasal sinuses, a paired pyramid-shaped air sinus located within the maxillary bone which drains via the maxillary ostium into the infundibulum, then through the hiatus semilunaris into the middle meatus of the nose" []
synonym: "absent antrum of Highmore" EXACT []
synonym: "absent genyantrum" EXACT []
synonym: "absent maxillary antra" EXACT []
synonym: "absent maxillary antrum" EXACT []
synonym: "missing maxillary sinus" EXACT []
is_a: MP:0002247 ! abnormal maxillary sinus morphology
is_a: MP:0030382 ! absent paranasal sinus
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T13:08:55Z" xsd:dateTime

[Term]
id: MP:0030094
name: foramen magnum stenosis
def: "abnormal narrowing or constriction of the large orifice in the occipital bone through which the spinal cord passes to the cranial cavity and becomes continuous with the medulla oblongata" [https://orcid.org/0000-0002-6490-7723]
synonym: "constricted foramen magnum" EXACT []
synonym: "great foramen stenosis" EXACT []
synonym: "narrow foramen magnum" EXACT []
synonym: "narrowed foramen magnum" EXACT []
is_a: MP:0010941 ! abnormal foramen magnum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-11T13:41:18Z" xsd:dateTime

[Term]
id: MP:0030095
name: abnormal midface morphology
def: "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
synonym: "abnormal midfacial region morphology" EXACT []
synonym: "midface abnormalities" EXACT []
synonym: "midface malformation" NARROW []
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T08:25:03Z" xsd:dateTime

[Term]
id: MP:0030096
name: abnormal periauricular region morphology
def: "any structural anomaly of the region around the ear" [HP:0000383, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal periauricular area morphology" EXACT []
synonym: "periauricular region abnormalities" EXACT []
synonym: "periauricular region malformation" NARROW []
is_a: MP:0030095 ! abnormal midface morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T09:04:24Z" xsd:dateTime

[Term]
id: MP:0030097
name: preauricular pit
def: "small indentation anterior to the insertion of the ear" [HP:0004467, PMID:19152421]
synonym: "pit in front of the ear" EXACT []
synonym: "preauricular earpits" EXACT []
synonym: "preauricular fistulas" EXACT []
synonym: "preauricular pits" EXACT []
synonym: "preauricular sinus" EXACT []
is_a: MP:0030096 ! abnormal periauricular region morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T09:18:17Z" xsd:dateTime

[Term]
id: MP:0030098
name: periorbital fullness
def: "increase in periorbital soft tissue" [HP:0000629]
synonym: "fullness around the eye sockets" EXACT []
synonym: "fullness around the eyes" NARROW []
synonym: "periorbital puffiness" EXACT []
is_a: MP:0030038 ! abnormal periorbital region morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T09:39:55Z" xsd:dateTime

[Term]
id: MP:0030099
name: facial asymmetry
def: "an abnormal difference between the left and right sides of the face" [HP:0000324]
synonym: "asymmetric faces" EXACT []
synonym: "asymmetry of the face" EXACT []
synonym: "asymmetry of the right and left side of the face" EXACT []
synonym: "crooked face" EXACT []
synonym: "unbalanced face" RELATED []
synonym: "unequal sides of the face" RELATED []
synonym: "uneven face" RELATED []
synonym: "uneven sides of the face" RELATED []
synonym: "unsymmetrical face" EXACT []
is_a: MP:0008863 ! craniofacial asymmetry
is_a: MP:0030071 ! abnormal face shape
is_a: MP:0030313 ! abnormal face development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T09:59:57Z" xsd:dateTime

[Term]
id: MP:0030100
name: hemifacial hypoplasia
def: "unilateral decrease in the number of normal cells in normal arrangement in the facial tissues, including muscles and bones, typically resulting in decreased size of one side of the face" [HP:0011332, https://orcid.org/0000-0002-6490-7723]
synonym: "hemifacial microsomia" RELATED []
synonym: "hypoplasia of half of the face" EXACT []
synonym: "hypoplasia of one side of the face" EXACT []
is_a: MP:0030065 ! face hypoplasia
is_a: MP:0030099 ! facial asymmetry
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T10:39:31Z" xsd:dateTime

[Term]
id: MP:0030101
name: carious teeth
def: "formation of cavities in the teeth due to a multifactorial bacterial infection that causes demineralization and destruction of the hard tissues of the teeth (enamel, dentin and cementum), usually by production of acid by bacterial fermentation of the food debris accumulated on the tooth surface" [http://medical-dictionary.thefreedictionary.com/saprodontia, http://www.dictionary.com/browse/dental-caries, https://en.wikipedia.org/wiki/Tooth_decay]
synonym: "caries" EXACT []
synonym: "dental caries" EXACT []
synonym: "dental cavities" EXACT []
synonym: "dental decay" RELATED []
synonym: "rotting teeth" RELATED []
synonym: "saprodontia" RELATED []
synonym: "tooth cavities" EXACT []
synonym: "tooth decay" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T11:17:31Z" xsd:dateTime

[Term]
id: MP:0030102
name: absent orbitosphenoid bone
def: "missing the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of the lesser wing of the sphenoid bone" EXACT []
synonym: "absence of the small wing of the sphenoid bone" EXACT []
synonym: "absent alae orbitales" RELATED []
synonym: "missing orbitosphenoid bone" EXACT []
is_a: MP:0004457 ! abnormal orbitosphenoid bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T11:40:22Z" xsd:dateTime

[Term]
id: MP:0030103
name: abnormal orbit shape
def: "any anomaly in the characteristic surface outline or contour of the orbits of an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eye socket shape" EXACT []
synonym: "orbit shape abnormalities" EXACT []
is_a: MP:0010030 ! abnormal orbit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T11:55:13Z" xsd:dateTime

[Term]
id: MP:0030104
name: round orbits
def: "orbits present a more circular rather than the ususal oval appearance" [https://orcid.org/0000-0002-6490-7723, PMID:27671791]
synonym: "circular eye sockets" EXACT []
synonym: "circular orbits" EXACT []
synonym: "round eye sockets" EXACT []
synonym: "rounded eye sockets" EXACT []
synonym: "rounded orbits" EXACT []
is_a: MP:0030103 ! abnormal orbit shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T12:00:47Z" xsd:dateTime

[Term]
id: MP:0030105
name: bushy muzzle
def: "excessive hair growth on or around the muzzle" [https://orcid.org/0000-0002-6490-7723]
synonym: "bushy snout" EXACT []
synonym: "excessively hairy muzzle" EXACT []
synonym: "excessively hairy snout" EXACT []
is_a: MP:0000412 ! excessive hair
is_a: MP:0000443 ! abnormal snout morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T12:24:10Z" xsd:dateTime

[Term]
id: MP:0030106
name: small incus
def: "reduced size of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [https://radiopaedia.org/articles/incus]
synonym: "decreased incus size" EXACT []
synonym: "reduced incus size" EXACT []
is_a: MP:0005106 ! abnormal incus morphology
is_a: MP:0030123 ! small middle ear ossicles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T13:14:46Z" xsd:dateTime

[Term]
id: MP:0030107
name: incus hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the incus, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic incus" EXACT []
is_a: MP:0030106 ! small incus
is_a: MP:0030124 ! middle ear ossicle hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T13:20:47Z" xsd:dateTime

[Term]
id: MP:0030108
name: abnormal incudostapedial joint morphology
def: "any structural anomaly of the small synovial joint located between the lenticular process on the long crus of the incus and the head of the stapes" [http://medical-dictionary.thefreedictionary.com/incudostapedial+joint]
synonym: "abnormal incudostapedial articulation" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T13:30:12Z" xsd:dateTime

[Term]
id: MP:0030109
name: abnormal incudomalleolar joint morphology
def: "any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint]
synonym: "abnormal incudomallear articulation" EXACT []
synonym: "abnormal incudomallear joint morphology" EXACT []
synonym: "abnormal incudomalleolar articulation" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T13:35:19Z" xsd:dateTime

[Term]
id: MP:0030110
name: incudomalleolar fusion
def: "bony fusion of the incus and the malleus into a single structure" [https://orcid.org/0000-0002-6490-7723]
synonym: "incudomallear fusion" EXACT []
is_a: MP:0003740 ! fusion of middle ear ossicles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-12T13:44:23Z" xsd:dateTime

[Term]
id: MP:0030111
name: absent temporomandibular joint
def: "absence of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent temporomandibular articulation" EXACT []
synonym: "missing temporomandibular joint" EXACT []
synonym: "temporomandibular joint agenesis" EXACT []
is_a: MP:0011210 ! abnormal temporomandibular joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T06:26:00Z" xsd:dateTime

[Term]
id: MP:0030112
name: zygomatic bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the zygomatic bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic zygomatic bone" EXACT []
is_a: MP:0004468 ! small zygomatic bone
is_a: MP:0030386 ! facial bone hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T06:39:52Z" xsd:dateTime

[Term]
id: MP:0030113
name: maxillary sinus inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the maxillary sinuses" [https://orcid.org/0000-0002-6490-7723]
synonym: "inflamed cheek sinuses" EXACT []
synonym: "inflammation of the maxillary antrum" EXACT []
synonym: "maxillary antritis" EXACT []
synonym: "maxillary sinusitis" EXACT []
is_a: MP:0001872 ! sinus inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T07:02:13Z" xsd:dateTime

[Term]
id: MP:0030114
name: abnormal nasal columella morphology
def: "any structural anomaly of the tissue that links the nasal tip to the nasal base, and separates the nares; it is the inferior margin of the nasal septum" [https://elementsofmorphology.nih.gov/anatomy-nose.shtml]
synonym: "abnormal columella nasi morphology" EXACT []
synonym: "malformation of the nasal columella" EXACT []
is_a: MP:0002233 ! abnormal nose morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T08:05:00Z" xsd:dateTime

[Term]
id: MP:0030115
name: abnormal nasal tip morphology
def: "any structural anomaly of the tip of the nose located at the junction of the inferior margin of the nasal ridge and the columella" [HP:0000436]
synonym: "nasal tip malformation" EXACT []
synonym: "nose tip malformation" EXACT []
is_a: MP:0002233 ! abnormal nose morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T08:18:22Z" xsd:dateTime

[Term]
id: MP:0030116
name: bifid nasal tip
def: "a splitting of the nasal tip; visually assessable vertical indentation, cleft, or depression of the nasal tip" [HP:0000456]
synonym: "bifid tip of nose" EXACT []
synonym: "cleft nasal tip" EXACT []
synonym: "cleft tip of nose" RELATED []
synonym: "notched nasal tip" RELATED []
synonym: "notched tip of nose" RELATED []
synonym: "split nasal tip" EXACT []
is_a: MP:0030115 ! abnormal nasal tip morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T08:29:00Z" xsd:dateTime

[Term]
id: MP:0030117
name: bifid nose
def: "visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip" [HP:0011803, PMID:19152422]
synonym: "bifid nasal bridge" EXACT []
synonym: "cleft nasal bridge" RELATED []
synonym: "cleft nose" RELATED []
synonym: "indented bridge of nose" RELATED []
synonym: "split nose" EXACT []
is_a: MP:0002233 ! abnormal nose morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T08:45:39Z" xsd:dateTime

[Term]
id: MP:0030118
name: rhinosinusitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membranes of the nose and in one or more paranasal sinuses" [https://orcid.org/0000-0002-6490-7723, https://www.merriam-webster.com/medical/rhinosinusitis]
is_a: MP:0001867 ! rhinitis
is_a: MP:0001872 ! sinus inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T09:19:58Z" xsd:dateTime

[Term]
id: MP:0030119
name: abnormal retrotympanic process morphology
def: "any structural anomaly of the posterior extension of the squamosal bone that lies just above the incus" [PMID:28566723]
synonym: "retrotympanic process malformation" EXACT []
is_a: MP:0004423 ! abnormal temporal bone squamous part morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T09:59:23Z" xsd:dateTime

[Term]
id: MP:0030120
name: absent retrotympanic process
def: "absence of the posterior extension of the squamosal bone that normally lies just above the incus" [https://orcid.org/0000-0002-6490-7723, PMID:28566723]
is_a: MP:0030119 ! abnormal retrotympanic process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:08:40Z" xsd:dateTime

[Term]
id: MP:0030121
name: small temporal bone squamous part
def: "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased squamosal bone size" EXACT []
synonym: "decreased squamous temporal bone size" EXACT []
synonym: "reduced squamosal bone size" EXACT []
synonym: "reduced squamous temporal bone size" EXACT []
synonym: "small squamosal bone" EXACT []
synonym: "small squamous bone" EXACT []
synonym: "small squamous part of temporal bone" EXACT []
synonym: "small temporal squama" EXACT []
is_a: MP:0004423 ! abnormal temporal bone squamous part morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:13:14Z" xsd:dateTime

[Term]
id: MP:0030122
name: temporal bone squamous part hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the temporal bone squamous part, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic squamosal bone" EXACT []
synonym: "hypoplastic squamous bone" EXACT []
synonym: "hypoplastic squamous part of temporal bone" EXACT []
synonym: "hypoplastic squamous temporal bone" EXACT []
synonym: "hypoplastic temporal squama" EXACT []
synonym: "squamosal bone hypoplasia" EXACT []
is_a: MP:0030121 ! small temporal bone squamous part
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:21:04Z" xsd:dateTime

[Term]
id: MP:0030123
name: small middle ear ossicles
def: "reduced size of the three bones of the middle ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "small middle ear bones" EXACT []
is_a: MP:0005105 ! abnormal middle ear ossicle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:30:40Z" xsd:dateTime

[Term]
id: MP:0030124
name: middle ear ossicle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the middle ear ossicle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic middle ear bones" EXACT []
synonym: "hypoplastic middle ear ossicles" EXACT []
is_a: MP:0030123 ! small middle ear ossicles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:36:27Z" xsd:dateTime

[Term]
id: MP:0030125
name: small gonial bone
def: "reduced size of the investing bone that lies on the surface of the malleus" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased gonial bone size" EXACT []
synonym: "decreased gonium size" EXACT []
synonym: "reduced gonial bone size" EXACT []
synonym: "reduced gonium size" EXACT []
synonym: "small gonium" EXACT []
is_a: MP:0008380 ! abnormal gonial bone morphology
is_a: MP:0030123 ! small middle ear ossicles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T10:55:54Z" xsd:dateTime

[Term]
id: MP:0030126
name: torticollis
def: "involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head" [HP:0000473]
synonym: "cervical dystonia" EXACT []
synonym: "loxia" EXACT []
synonym: "spasmodic torticollis" EXACT []
synonym: "twisted neck" EXACT []
synonym: "wry neck" EXACT []
is_a: MP:0005323 ! dystonia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T11:32:06Z" xsd:dateTime

[Term]
id: MP:0030127
name: small stapes
def: "reduced size of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased stapes size" EXACT []
synonym: "reduced stapes size" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology
is_a: MP:0030123 ! small middle ear ossicles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T12:14:54Z" xsd:dateTime

[Term]
id: MP:0030128
name: stapes hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the stapes, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic stapes" EXACT []
synonym: "stapedial hypoplasia" EXACT []
is_a: MP:0030124 ! middle ear ossicle hypoplasia
is_a: MP:0030127 ! small stapes
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-13T12:19:22Z" xsd:dateTime

[Term]
id: MP:0030129
name: tongue inflammation
def: "local accumulation of fluid, plasma proteins and leukocytes in the tongue" [https://orcid.org/0000-0002-6490-7723]
synonym: "glossitis" EXACT []
synonym: "lingual inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T09:25:01Z" xsd:dateTime

[Term]
id: MP:0030130
name: gum inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the gums" [https://orcid.org/0000-0002-6490-7723]
synonym: "gingival inflammation" EXACT []
synonym: "gingivitis" EXACT []
synonym: "inflamed gums" EXACT []
synonym: "red and swollen gums" EXACT []
is_a: MP:0030132 ! periodontium inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T09:35:46Z" xsd:dateTime

[Term]
id: MP:0030131
name: abnormal periodontium morphology
def: "any structural anomaly of the specialized tissues that both surround and support the teeth, maintaining them in the maxillary and mandibular bones; it consists of four principal components: the gums (gingiva), periodontal ligament, cementum, and alveolar bone proper" [https://en.wikipedia.org/wiki/Periodontium]
synonym: "abnormal periodontal structures" EXACT []
synonym: "periodontal abnormalities" BROAD []
is_a: MP:0000452 ! abnormal mouth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T10:03:51Z" xsd:dateTime

[Term]
id: MP:0030132
name: periodontium inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the periodontium (including the gums and supporting structures of the teeth)" [https://orcid.org/0000-0002-6490-7723]
synonym: "periodontal inflammation" EXACT []
synonym: "periodontitis" EXACT []
synonym: "pyorrhea" EXACT []
is_a: MP:0001846 ! increased inflammatory response
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T10:42:55Z" xsd:dateTime

[Term]
id: MP:0030133
name: small third pharyngeal arch
def: "reduced size of the third branchial arch" []
synonym: "small third branchial arch" EXACT []
is_a: MP:0006339 ! abnormal third pharyngeal arch morphology
is_a: MP:0006346 ! small pharyngeal arch
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T11:28:16Z" xsd:dateTime

[Term]
id: MP:0030134
name: small fourth pharyngeal arch
def: "reduced size of the fourth branchial arch" [https://orcid.org/0000-0002-6490-7723]
synonym: "small fourth branchial arch" EXACT []
is_a: MP:0006340 ! abnormal fourth pharyngeal arch morphology
is_a: MP:0006346 ! small pharyngeal arch
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T11:44:38Z" xsd:dateTime

[Term]
id: MP:0030135
name: small sixth pharyngeal arch
def: "reduced size of the sixth branchial arch" [https://orcid.org/0000-0002-6490-7723]
synonym: "small sixth branchial arch" EXACT []
is_a: MP:0006346 ! small pharyngeal arch
is_a: MP:0006347 ! abnormal sixth pharyngeal arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T12:08:17Z" xsd:dateTime

[Term]
id: MP:0030136
name: abnormal lower incisor morphology
def: "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lower jaw incisor morphology'" EXACT []
synonym: "abnormal mandibular incisor morphology" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T12:28:00Z" xsd:dateTime

[Term]
id: MP:0030137
name: abnormal upper incisor morphology
def: "any structural anomaly of the upper set of long teeth that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal maxillary incisor morphology" EXACT []
synonym: "abnormal upper jaw incisor morphology" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T12:33:27Z" xsd:dateTime

[Term]
id: MP:0030138
name: abnormal lower incisor color
def: "anomaly in the color and shading of the lower incisors, which normally presents in shades of white" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lower incisor colour" EXACT []
synonym: "abnormal mandibular incisor color" EXACT []
synonym: "abnormal mandibular incisor colour" EXACT []
is_a: MP:0010096 ! abnormal incisor color
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T12:45:16Z" xsd:dateTime

[Term]
id: MP:0030139
name: abnormal upper incisor color
def: "anomaly in the color and shading of the upper incisors, which normally presents in shades of white" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal maxillary incisor color" EXACT []
synonym: "abnormal maxillary incisor colour" EXACT []
synonym: "abnormal upper incisor colour" EXACT []
is_a: MP:0010096 ! abnormal incisor color
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-14T12:50:30Z" xsd:dateTime

[Term]
id: MP:0030140
name: facial muscle atrophy
def: "acquired diminution of facial muscle tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic facial muscle" EXACT []
synonym: "atrophic facial muscles" EXACT []
is_a: MP:0009417 ! skeletal muscle atrophy
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T06:10:38Z" xsd:dateTime

[Term]
id: MP:0030141
name: facial paralysis
def: "severe or complete loss of power of voluntary movement in muscles of the face through injury or disease of it or its nerve supply; facial muscles are innervated by the facial nerve (i.e., the seventh cranial nerve)" [https://orcid.org/0000-0002-6490-7723]
synonym: "facial muscle paralysis" EXACT []
synonym: "paralysis of the muscles of the face" EXACT []
is_a: MP:0000753 ! paralysis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T06:44:39Z" xsd:dateTime

[Term]
id: MP:0030142
name: facial muscle degeneration
def: "pathological deterioration of facial muscle tissue, often accompanied by loss of function" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009415 ! skeletal muscle degeneration
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T07:14:40Z" xsd:dateTime

[Term]
id: MP:0030143
name: facial muscle spasm
def: "sudden, repetitive, nonrhythmic motor movements (spasms) involving the muscles of the face; common types of facial spasms include rapid, repetitive squinting or blinking, grimacing, mouth twitching, and nose twitching" [HP:0011468, https://www.healthgrades.com/symptoms/facial-spasms]
synonym: "cramping of the facial muscles" EXACT []
synonym: "facial spasms" EXACT []
synonym: "facial tics" EXACT []
synonym: "involuntary facial muscle spasms" RELATED []
synonym: "jerking of the facial muscles" EXACT []
synonym: "mimic spasms" EXACT []
synonym: "muscle spasm of the face" RELATED []
synonym: "myoclonus of facial muscles" BROAD []
synonym: "spasms of the facial muscles" EXACT []
synonym: "twitching of facial muscles" EXACT []
is_a: MP:0000743 ! muscle spasm
is_a: MP:0030144 ! abnormal facial muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T07:22:10Z" xsd:dateTime

[Term]
id: MP:0030144
name: abnormal facial muscle physiology
def: "any functional anomaly of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002106 ! abnormal muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T08:01:14Z" xsd:dateTime

[Term]
id: MP:0030145
name: abnormal digastric anterior belly morphology
def: "any structural anomaly of the anterior belly of the digastric muscle which arises from a depression on the inner side of the lower border of the mandible called the digastric fossa, close to the symphysis, and passes downward and backward; the anterior body originates from the first pharyngeal arch and is supplied by the trigeminal via the mylohyoid nerve, a branch of the inferior alveolar nerve, itself a branch of the mandibular division of the trigeminal nerve" []
synonym: "abnormal anterior digastricus morphology" EXACT []
synonym: "abnormal digastric muscle anterior belly morphology" EXACT []
xref: https://en.wikipedia.org/wiki/Digastric_muscle
is_a: MP:0013815 ! abnormal digastric muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T08:34:52Z" xsd:dateTime

[Term]
id: MP:0030146
name: abnormal digastric posterior belly morphology
def: "any structural anomaly of the longer, posterior belly of the digastric muscle arising from the mastoid notch which is on the inferior surface of the skull, medial to the mastoid process of the temporal bone; the posterior belly is supplied by the digastric branch of facial nerve" []
synonym: "abnormal caudal digastricus morphology" EXACT []
synonym: "abnormal digastric muscle posterior belly morphology" EXACT []
xref: https://en.wikipedia.org/wiki/Digastric_muscle
is_a: MP:0013815 ! abnormal digastric muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T08:49:22Z" xsd:dateTime

[Term]
id: MP:0030147
name: abnormal digastric muscle physiology
def: "any functional anomaly of the digastric muscle whose action elevates the hyoid when the mandible is fixed and depresses the mandible when the hyoid is fixed; when the two bellies of the digastric contract, they pull upward on the hyoid bone; but if the hyoid is fixed from below, the digastric assists in extreme opening of the mouth such as yawning or taking a large bite" []
synonym: "abnormal digastricus physiology" EXACT []
xref: https://en.wikipedia.org/wiki/Suprahyoid_muscles
is_a: MP:0030144 ! abnormal facial muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T08:56:48Z" xsd:dateTime

[Term]
id: MP:0030148
name: abnormal mylohyoid muscle morphology
def: "any structural anomaly of the flat and triangular paired muscle that runs from the mandible to the hyoid bone forming the muscular floor of the oral cavity of the mouth; it is a suprahyoid muscle derived from the first pharyngeal arch that is situated immediately superior to the anterior belly of the digastric muscle" []
xref: https://en.wikipedia.org/wiki/Mylohyoid_muscle
is_a: MP:0030240 ! abnormal suprahyoid muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T09:47:34Z" xsd:dateTime

[Term]
id: MP:0030149
name: abnormal stylohyoid muscle morphology
def: "any structural anomaly of the slender suprahyoid muscle lying anterior and superior of the posterior belly of the digastric muscle; it arises from the styloid process of the temporal bone and inserts into the body of the hyoid bone; it is perforated, near its insertion, by the intermediate tendon of the digastric muscle; the stylohyoid elevates and retracts the hyoid bone, elongating the floor of the mouth during swallowing" []
xref: https://en.wikipedia.org/wiki/Stylohyoid_muscle
xref: https://en.wikipedia.org/wiki/Suprahyoid_muscles
is_a: MP:0030240 ! abnormal suprahyoid muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T10:28:26Z" xsd:dateTime

[Term]
id: MP:0030150
name: absent stylohyoid muscle
def: "absence of the slender suprahyoid muscle lying anterior and superior of the posterior belly of the digastric muscle that elevates and retracts the hyoid bone, elongating the floor of the mouth during swallowing" [https://en.wikipedia.org/wiki/Stylohyoid_muscle, https://en.wikipedia.org/wiki/Suprahyoid_muscles]
is_a: MP:0030149 ! abnormal stylohyoid muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T10:46:31Z" xsd:dateTime

[Term]
id: MP:0030151
name: abnormal buccinator muscle morphology
def: "any structural anomaly of the thin quadrilateral muscle occupying the interval between the maxilla and the mandible at the side of the face that forms the anterior part of the cheek or the lateral wall of the oral cavity; it compresses the cheeks against the teeth and is used in acts such as blowing; it is an assistant muscle of mastication and in neonates it is used to suckle" []
xref: https://en.wikipedia.org/wiki/Buccinator_muscle
is_a: MP:0030039 ! abnormal facial muscle morphology
is_a: MP:0030246 ! abnormal cheek morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T11:59:36Z" xsd:dateTime

[Term]
id: MP:0030152
name: abnormal depressor anguli oris muscle morphology
def: "any structural anomaly of the facial muscle that originates from the mandible and inserts into the angle of the mouth; it is innervated by the marginal mandibular branch of the facial nerve and receives its blood supply from the facial artery; the muscle depresses the corners of the mouth which is associated with frowning" []
synonym: "abnormal triangularis muscle morphology" EXACT []
xref: https://en.wikipedia.org/wiki/Depressor_anguli_oris_muscle
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-18T12:37:33Z" xsd:dateTime

[Term]
id: MP:0030153
name: dental pulp inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in dental pulp tissue; commonly associated with a bacterial infection but can also be due to other insults such as repetitive trauma or in rare cases periodontitis" [https://en.wikipedia.org/wiki/Pulpitis, https://orcid.org/0000-0002-6490-7723]
synonym: "pulpitis" EXACT []
synonym: "tooth pulp inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0031623 ! abnormal tooth physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T05:25:53Z" xsd:dateTime

[Term]
id: MP:0030154
name: abnormal tympanic cavity morphology
def: "any structural anomaly of the small, air-filled, mucosa-lined cavity that is located in the petrous portion of the temporal bone and houses the auditory ossicles and intratympanic muscles (tensor tympani and stapedius) as well as the chorda tympani and the tympanic plexus of nerves; it is split into two parts: the tympanic cavity proper (the space directly internal to the tympanic membrane) and the epitympanic recess or attic (the space superior to the tympanic membrane)" []
synonym: "abnormal middle ear cavity morphology" EXACT []
xref: http://www.dummies.com/education/science/anatomy/the-anatomy-of-the-middle-ear/
xref: https://radiopaedia.org/articles/middle-ear
xref: https://www.kenhub.com/en/start/c/ear
is_a: MP:0000049 ! abnormal middle ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T06:28:32Z" xsd:dateTime

[Term]
id: MP:0030155
name: absent tympanic cavity
def: "absence of the small, air-filled, mucosa-lined cavity that is located in the petrous portion of the temporal bone and houses the auditory ossicles and intratympanic muscles (tensor tympani and stapedius) as well as the chorda tympani and the tympanic plexus of nerves" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent middle ear cavity" EXACT []
is_a: MP:0030154 ! abnormal tympanic cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T08:32:14Z" xsd:dateTime

[Term]
id: MP:0030156
name: abnormal tympanic cavity muscle morphology
def: "any structural anomaly of either of the two tiny striated muscles (tensor tympani and stapedius) located within the tympanic cavity; these muscles contract in response to loud noise, inhibiting the vibrations of the malleus, incus and stapes, and reducing the transmission of sound to the inner ear" []
synonym: "abnormal auditory ossicle muscle morphology" EXACT []
synonym: "abnormal intratympanic muscle morphology" EXACT []
synonym: "abnormal middle ear muscle morphology" EXACT []
xref: http://emedicine.medscape.com/article/874456-overview#a6
xref: http://teachmeanatomy.info/head/organs/ear/middle-ear/
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0030154 ! abnormal tympanic cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T09:36:12Z" xsd:dateTime

[Term]
id: MP:0030157
name: abnormal stapedius muscle morphology
def: "any structural anomaly of the tiny striated muscle found in the pyramidal eminence on the posterior wall of the tympanic cavity, whose tendon inserts onto the neck of the stapes; like the tensor tympani, it helps to dampen loud sounds; it is innervated by a small branch from the facial nerve" []
synonym: "abnormal stapedius morphology" EXACT []
xref: http://www.dummies.com/education/science/anatomy/the-anatomy-of-the-middle-ear/
is_a: MP:0030039 ! abnormal facial muscle morphology
is_a: MP:0030156 ! abnormal tympanic cavity muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T10:04:47Z" xsd:dateTime

[Term]
id: MP:0030158
name: absent stapedius muscle
def: "missing the tiny muscle normally found in the pyramidal eminence on the posterior wall of the tympanic cavity, whose tendon inserts onto the neck of the stapes" [https://orcid.org/0000-0002-6490-7723]
synonym: "missing stapedius muscle" EXACT []
is_a: MP:0030157 ! abnormal stapedius muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T10:11:15Z" xsd:dateTime

[Term]
id: MP:0030159
name: abnormal tensor tympani muscle morphology
def: "any structural anomaly of the tiny striated muscle that originates superior to the pharyngotympanic tube, the sphenoid, and the temporal bone and inserts into the handle of the malleus; it tenses the tympanic membrane and dampens the movements of the auditory ossicles to prevent ear damage from loud sounds; it is innervated by the trigeminal nerve" []
synonym: "abnormal tensor tympani morphology" EXACT []
xref: http://www.dummies.com/education/science/anatomy/the-anatomy-of-the-middle-ear/
is_a: MP:0030156 ! abnormal tympanic cavity muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T10:51:26Z" xsd:dateTime

[Term]
id: MP:0030160
name: abnormal auditory bulla morphology
def: "any structural anomaly of the hollow bony structure on the ventral, posterior portion of the skull that encloses parts of the middle and inner ear; in most species, it is formed by the tympanic part of the temporal bone" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone]
synonym: "abnormal auditory bullae" RELATED []
synonym: "abnormal bulla morphology" BROAD []
synonym: "abnormal bulla tympanica morphology" RELATED []
synonym: "abnormal tympanic bulla morphology" RELATED []
is_a: MP:0002102 ! abnormal ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T11:33:05Z" xsd:dateTime

[Term]
id: MP:0030161
name: absent auditory bulla
def: "absence of the hollow bony structure normally found on the ventral, posterior portion of the skull that encloses parts of the middle and inner ear; in most species, it is formed by the tympanic part of the temporal bone" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030160 ! abnormal auditory bulla morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T11:42:54Z" xsd:dateTime

[Term]
id: MP:0030162
name: absent hyoid bone body
def: "absence of the main curve of the hyoid bone from which the horns extend" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent basihyal bone" EXACT []
synonym: "absent basihyoid" EXACT []
synonym: "absent corpus ossis hyoidei" RELATED []
synonym: "absent hyoid bone base" EXACT []
synonym: "missing hyoid bone body" EXACT []
is_a: MP:0009917 ! abnormal hyoid bone body morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T12:11:14Z" xsd:dateTime

[Term]
id: MP:0030163
name: abnormal canthus morphology
def: "any structural anomaly of either corner of the eye where the upper and lower eyelids meet; more specifically, the inner and outer canthi are, respectively, the medial and lateral ends/angles of the palpebral fissure" [https://en.wikipedia.org/wiki/Canthus]
synonym: "abnormal canthi" EXACT []
synonym: "abnormal palpebral commissure morphology" EXACT []
synonym: "abnormal palpebral commissures" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T12:37:24Z" xsd:dateTime

[Term]
id: MP:0030164
name: abnormal inner canthus morphology
def: "any structural anomaly of the inner corner of the eye where the upper and lower eyelids meet, i.e. the medial end/angle of the palpebral fissure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal medial canthus morphology" EXACT []
synonym: "abnormal medial palpebral commissure morphology" EXACT []
is_a: MP:0030163 ! abnormal canthus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T12:51:12Z" xsd:dateTime

[Term]
id: MP:0030165
name: abnormal outer canthus morphology
def: "any structural anomaly of the outer corner of the eye where the upper and lower eyelids meet, i.e. the lateral end/angle of the palpebral fissure" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lateral canthus morphology" EXACT []
synonym: "abnormal lateral palpebral commissure morphology" EXACT []
synonym: "abnormal temporal canthus morphology" RELATED []
is_a: MP:0030163 ! abnormal canthus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T12:59:31Z" xsd:dateTime

[Term]
id: MP:0030166
name: increased inner canthal distance
def: "increased distance between the inner corners (medial canthi) of the eyes where the eyelids meet; may be present without or with ocular hypertelorism (where interpupillary distance is increased)" [HP:0000506, https://en.wikipedia.org/wiki/Telecanthus, PMID:19125427]
synonym: "dystopia canthorum" EXACT []
synonym: "increased distance between the inner canthi" EXACT []
synonym: "increased distance between the medial canthi" EXACT []
synonym: "increased inner intercanthal distance" EXACT []
synonym: "increased intercanthal distance" EXACT []
synonym: "telecanthus" EXACT []
synonym: "widely separated inner corners of the eyes" EXACT []
is_a: MP:0030163 ! abnormal canthus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T13:19:13Z" xsd:dateTime

[Term]
id: MP:0030167
name: decreased inner canthal distance
def: "decreased distance between the inner corners (medial canthi) of the eyes where the eyelids meet" [https://orcid.org/0000-0002-6490-7723]
synonym: "closely spaced inner corners of the eyes" EXACT []
synonym: "decreased distance between the inner canthi" EXACT []
synonym: "decreased distance between the medial canthi" EXACT []
synonym: "decreased inner intercanthal distance" EXACT []
synonym: "reduced intercanthal distance" EXACT []
is_a: MP:0030163 ! abnormal canthus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-21T13:30:28Z" xsd:dateTime

[Term]
id: MP:0030168
name: thin upper lip
def: "upper lips having a reduced amount of soft tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin top lip" EXACT []
synonym: "thin top lip vermilion" RELATED []
synonym: "thin upper lip vermilion" RELATED []
is_a: MP:0003775 ! thin lip
is_a: MP:0012523 ! abnormal upper lip morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T06:07:12Z" xsd:dateTime

[Term]
id: MP:0030169
name: thick upper lip
def: "upper lips having an abundance and often an excess of soft tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "fleshy top lip" EXACT []
synonym: "fleshy upper lip" EXACT []
synonym: "full top lip" EXACT []
synonym: "full upper lip" EXACT []
synonym: "prominent top lip" EXACT []
synonym: "prominent upper lip" EXACT []
synonym: "thick top lip" EXACT []
synonym: "thick top lip vermilion" RELATED []
synonym: "thick upper lip vermilion" RELATED []
is_a: MP:0003774 ! thick lip
is_a: MP:0012523 ! abnormal upper lip morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T06:45:20Z" xsd:dateTime

[Term]
id: MP:0030170
name: absent mandibular symphysis
def: "absence of the fibrocartilagenous union of the two halves of the mandible (embryonic stages)" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent inter-mandibular joint" EXACT []
synonym: "absent intermandibular joint" EXACT []
synonym: "absent mental symphysis" RELATED []
synonym: "absent symphysis mandibulae" RELATED []
synonym: "absent symphysis mentalis" RELATED []
synonym: "absent symphysis menti" EXACT []
is_a: MP:0001649 ! abnormal mandibular symphysis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T07:50:55Z" xsd:dateTime

[Term]
id: MP:0030171
name: absent extraocular muscles
def: "missing the striated muscles that are located within the orbit but are extrinsic and separate from the eyeball itself and control the movements of the eyeball and the superior eyelid" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent extra-ocular muscles" EXACT []
synonym: "missing extra-ocular muscles" EXACT []
synonym: "missing extraocular muscles" EXACT []
is_a: MP:0005247 ! abnormal extraocular muscle morphology
is_a: MP:0013929 ! absent eye muscles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T09:03:31Z" xsd:dateTime

[Term]
id: MP:0030172
name: abnormal eyelid muscle morphology
def: "any structural anomaly of any of the muscles that attach to an eyelid" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001340 ! abnormal eyelid morphology
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T09:27:24Z" xsd:dateTime

[Term]
id: MP:0030173
name: abnormal orbicularis oculi muscle morphology
def: "any structural anomaly of the ring-like (sphincter) facial muscle composed of skeletal muscle fibers and arranged in concentric bands around the upper and lower eyelids; its function is to close the eyelids, and to help in the passing and draining of tears through the punctum, canaliculi, and lacrimal sac, all parts of the tear drainage system" [http://www.healthline.com/human-body-maps/orbicularis-oculi-muscle]
synonym: "abnormal orbicularis oculi morphology" EXACT []
is_a: MP:0003686 ! abnormal eye muscle morphology
is_a: MP:0030172 ! abnormal eyelid muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T10:12:14Z" xsd:dateTime

[Term]
id: MP:0030174
name: absent orbicularis oculi muscle
def: "absence of the ring-like (sphincter) facial muscle composed of skeletal muscle fibers and arranged in concentric bands around the upper and lower eyelids; its primary function is to close the eyelids" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent orbicularis oculi" EXACT []
synonym: "missing orbicularis oculi" EXACT []
synonym: "orbicularis oculi agenesis" EXACT []
is_a: MP:0013929 ! absent eye muscles
is_a: MP:0030173 ! abnormal orbicularis oculi muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T10:48:40Z" xsd:dateTime

[Term]
id: MP:0030175
name: orbicularis oculi muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the orbicularis oculi muscle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic orbicularis oculi muscle" EXACT []
synonym: "orbicularis oculi hypoplasia" EXACT []
is_a: MP:0030173 ! abnormal orbicularis oculi muscle morphology
is_a: MP:0030426 ! facial muscle hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T10:54:16Z" xsd:dateTime

[Term]
id: MP:0030176
name: abnormal levator labii superioris muscle morphology
def: "any structural anomaly of the facial muscle that is shaped like a broad, flat sheet, the origin of which extends from the side of the nose to the zygomatic bone; its main function is to elevate the upper lip" [https://en.wikipedia.org/wiki/Levator_labii_superioris]
synonym: "abnormal levator labii maxillaris morphology" EXACT []
synonym: "abnormal levator labii superioris morphology" EXACT []
synonym: "abnormal quadratus labii superioris morphology" EXACT []
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T11:14:09Z" xsd:dateTime

[Term]
id: MP:0030177
name: absent levator labii superioris muscle
def: "missing the facial muscle that is shaped like a broad, flat sheet, the origin of which extends from the side of the nose to the zygomatic bone; its main function is to elevate the upper lip" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent levator labii maxillaris muscle" EXACT []
synonym: "absent levator labii superioris" EXACT []
synonym: "absent quadratus labii superioris muscle" EXACT []
is_a: MP:0030040 ! absent facial muscle
is_a: MP:0030176 ! abnormal levator labii superioris muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T11:36:51Z" xsd:dateTime

[Term]
id: MP:0030178
name: abnormal scalp morphology
def: "any structural anomaly of the soft tissue envelope of the cranial vault that extends from the external occipital protuberance and superior nuchal lines to the supraorbital margins; it consists of 5 layers: the skin (and head hair), connective tissue, epicranial aponeurosis, loose areolar tissue, and pericranium; the first 3 layers are bound together as a single unit that can move along the loose areolar tissue over the pericranium, which is adherent to the calvaria" []
xref: HP:0001965
xref: http://emedicine.medscape.com/article/834808-overview
is_a: MP:0000432 ! abnormal head morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T13:44:52Z" xsd:dateTime

[Term]
id: MP:0030179
name: abnormal oral epithelium morphology
def: "any structural anomaly of the stratified squamous epithelium that forms part of the oral mucosa and lines the inner aspect of the oral cavity; depending on the mouth region, the epithelium may be non-keratinized or keratinized; non-keratinized squamous epithelium covers the soft palate, inner lips, inner cheeks, and the floor of the mouth, and ventral surface of the tongue; keratinized squamous epithelium is present in the attached gingiva and hard palate as well as areas of the dorsal surface of the tongue" [https://en.wikipedia.org/wiki/Oral_mucosa]
synonym: "abnormal epithelium of the mouth mucosa" EXACT []
synonym: "abnormal epithelium of the oral mucosa" EXACT []
is_a: MP:0003745 ! abnormal oral mucosa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T14:28:17Z" xsd:dateTime

[Term]
id: MP:0030180
name: abnormal nasal fin morphology
def: "any structural anomaly of the transient epithelial seam that develops by fusion between the epithelial linings of the medial and lateral nasal swellings; shortly after its formation the nasal fin regresses and is replaced by mesenchyme, with exception of its most posterior portion which remains as the bucconasal membrane" [UBERON:0009671]
is_a: MP:0030179 ! abnormal oral epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T14:59:06Z" xsd:dateTime

[Term]
id: MP:0030181
name: persistent nasal fins
def: "failure of the nasal fins to rupture during development leading to choanal obstruction/atresia" [PMID:14623956]
is_a: MP:0030180 ! abnormal nasal fin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T15:05:54Z" xsd:dateTime

[Term]
id: MP:0030182
name: abnormal oronasal membrane morphology
def: "any structural anomaly of the thin, transient epithelial sheet which separates the primordial nasal cavity from the stomatodeum; in mammals, bucconasal membranes demarcate the locations of the paired primitive choanae" [http://medical-dictionary.thefreedictionary.com/bucconasal+membrane, PMID:26293818] {comment="after lip fusion, degradation of the nasal fin and bucconasal membrane is necessary for reestablishing contact between the neonatal oral and nasal cavities through an open choana and for enabling nasal breathing in neonates"}
synonym: "abnormal bucconasal membrane morphology" EXACT []
synonym: "abnormal bucconasal membrane of Hochstetter morphology" EXACT []
synonym: "abnormal nasobuccal membrane of Hochstetter morphology" EXACT []
synonym: "abnormal oro-nasal membrane morphology" EXACT []
is_a: MP:0030180 ! abnormal nasal fin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T15:26:07Z" xsd:dateTime

[Term]
id: MP:0030183
name: persistent oronasal membrane
def: "failure of the oronasal membrane to rupture during development leading to choanal obstruction" [PMID:19648291]
synonym: "persistent bucconasal membrane" EXACT []
synonym: "persistent bucconasal membrane of Hochstetter" EXACT []
synonym: "persistent nasobuccal membrane of Hochstetter" EXACT []
synonym: "persistent oro-nasal membrane" EXACT []
is_a: MP:0030182 ! abnormal oronasal membrane morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-22T15:35:41Z" xsd:dateTime

[Term]
id: MP:0030184
name: abnormal zygomaticus muscle morphology
def: "any structural anomaly of the zygomaticus major and/or minor facial muscles that originate from the body of the zygoma and pass downwards to insert into the corner of the mouth and lateral aspect of the upper lip, respectively; these muscles receive their nerve supply on their deep surface from the zygomatic and buccal branches of the facial nerve and lift the corners of the mouth" [https://orcid.org/0000-0002-6490-7723, ISBN:978-3-642-21836-1]
is_a: MP:0030039 ! abnormal facial muscle morphology
is_a: MP:0030246 ! abnormal cheek morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T07:40:02Z" xsd:dateTime

[Term]
id: MP:0030185
name: abnormal minor zygomaticus muscle morphology
def: "any structural anomaly of the slender band of muscle on each side of the face that arises from the zygomatic bone, inserts into the upper lip between the zygomaticus major and the levator labii superioris, and acts to raise the upper lip upward and laterally" [http://medical-dictionary.thefreedictionary.com/zygomaticus+minor+muscle, https://www.merriam-webster.com/medical/zygomaticus%20minor]
synonym: "abnormal lesser zygomatic muscle morphology" EXACT []
synonym: "abnormal musculus zygomaticus minor morphology" EXACT []
synonym: "abnormal zygomaticus minor muscle morphology" EXACT []
is_a: MP:0030184 ! abnormal zygomaticus muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T08:01:53Z" xsd:dateTime

[Term]
id: MP:0030186
name: abnormal major zygomaticus muscle morphology
def: "any structural anomaly of the slender band of muscle on each side of the face that arises from the zygomatic bone, inserts into the orbicularis oris and skin at the corner of the mouth, and acts to pull the corner of the mouth upward and backward when smiling or laughing" [http://medical-dictionary.thefreedictionary.com/zygomaticus+major+muscle, https://www.merriam-webster.com/medical/zygomaticus%20major]
synonym: "abnormal greater zygomatic muscle morphology" EXACT []
synonym: "abnormal musculus zygomaticus major morphology" EXACT []
synonym: "abnormal zygomaticus major muscle morphology" EXACT []
is_a: MP:0030184 ! abnormal zygomaticus muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T08:14:07Z" xsd:dateTime

[Term]
id: MP:0030187
name: abnormal epitympanic recess morphology
def: "any structural anomaly of the upper portion of the tympanic cavity located above the tympanic membrane; it contains the head of the malleus and the body of the incus" [https://radiopaedia.org/articles/middle-ear, https://www.drugs.com/dict/epitympanum.html]
synonym: "abnormal epitympanum morphology" EXACT []
synonym: "abnormal Hyrtl epitympanic recess morphology" EXACT []
synonym: "abnormal tympanic attic morphology" EXACT []
is_a: MP:0030154 ! abnormal tympanic cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T08:55:38Z" xsd:dateTime

[Term]
id: MP:0030188
name: round snout
def: "appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [https://orcid.org/0000-0002-6490-7723]
synonym: "round muzzle" BROAD []
synonym: "round nose" NARROW []
synonym: "rounded muzzle" BROAD []
synonym: "rounded nose" NARROW []
synonym: "rounded snout" EXACT []
is_a: MP:0000443 ! abnormal snout morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T09:16:13Z" xsd:dateTime

[Term]
id: MP:0030189
name: broad snout
def: "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad muzzle" BROAD []
synonym: "broad nose" NARROW []
synonym: "wide muzzle" BROAD []
synonym: "wide nose" NARROW []
synonym: "wide snout" EXACT []
is_a: MP:0000443 ! abnormal snout morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T09:42:23Z" xsd:dateTime

[Term]
id: MP:0030190
name: small snout
def: "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased muzzle size" BROAD []
synonym: "decreased nose size" NARROW []
synonym: "decreased snout size" EXACT []
synonym: "reduced muzzle size" BROAD []
synonym: "reduced nose size" NARROW []
synonym: "reduced snout size" EXACT []
synonym: "small muzzle" BROAD []
synonym: "small nose" NARROW []
is_a: MP:0000443 ! abnormal snout morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T09:54:21Z" xsd:dateTime

[Term]
id: MP:0030191
name: narrow snout
def: "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow muzzle" BROAD []
synonym: "narrow nose" NARROW []
is_a: MP:0030190 ! small snout
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T10:05:29Z" xsd:dateTime

[Term]
id: MP:0030192
name: downturned snout
def: "muzzle has a curve or tilt such that the tip points downwards" [https://orcid.org/0000-0002-6490-7723]
synonym: "downturned muzzle" BROAD []
is_a: MP:0000443 ! abnormal snout morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-25T10:14:06Z" xsd:dateTime

[Term]
id: MP:0030193
name: short philtrum
def: "decreased length of the vertical groove found on the median line of the upper lip" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased philtral height" EXACT []
synonym: "decreased philtral length" EXACT []
synonym: "decreased philtrum height" EXACT []
synonym: "decreased philtrum length" EXACT []
synonym: "decreased vertical dimension of the philtrum" EXACT []
synonym: "reduced philtral height" EXACT []
synonym: "reduced philtral length" EXACT []
synonym: "reduced philtrum height" EXACT []
synonym: "reduced philtrum length" EXACT []
synonym: "shortened philtrum" EXACT []
is_a: MP:0012256 ! abnormal philtrum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T11:45:50Z" xsd:dateTime

[Term]
id: MP:0030194
name: abnormal intermaxillary suture morphology
def: "any structural anomaly of the anterior median suture between the two maxillae of the upper jawbone, located between the inferior border of the nasal aperture and the central incisor teeth; it usually ossifies later in life and becomes a synostosis" [http://www.anatomyexpert.com/app/structure/1673/43/, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal sutura intermaxillaris morphology" EXACT []
is_a: MP:0030230 ! abnormal facial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T11:56:02Z" xsd:dateTime

[Term]
id: MP:0030195
name: abnormal internasal suture morphology
def: "any structural anomaly of the cranial suture found between the left and right nasal bones" [https://orcid.org/0000-0002-6490-7723, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Internasal-suture]
is_a: MP:0030230 ! abnormal facial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T12:07:16Z" xsd:dateTime

[Term]
id: MP:0030196
name: abnormal nasomaxillary suture morphology
def: "any structural anomaly of the cranial suture found between the nasal bone and the frontal process of the maxilla" [https://orcid.org/0000-0002-6490-7723, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Nasomaxillary-suture]
synonym: "abnormal sutura nasomaxillaris morphology" EXACT []
is_a: MP:0030230 ! abnormal facial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T12:16:26Z" xsd:dateTime

[Term]
id: MP:0030197
name: small nasal septum
def: "reduced size of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nasal septum size" EXACT []
synonym: "reduced nasal septum size" EXACT []
is_a: MP:0002239 ! abnormal nasal septum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T12:50:50Z" xsd:dateTime

[Term]
id: MP:0030198
name: nasal septum hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the nasal septum, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic nasal septum" EXACT []
is_a: MP:0030197 ! small nasal septum
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T12:55:18Z" xsd:dateTime

[Term]
id: MP:0030199
name: deviated nasal septum
def: "displacement of the nasal septum in which the top of the cartilaginous ridge leans to the left or the right, causing obstruction of the affected nasal passage; normally, the septum lies centrally, and thus the nasal passages are symmetrical" [HP:0004411, https://en.wikipedia.org/wiki/Nasal_septum_deviation]
synonym: "crooked nasal septum" EXACT []
synonym: "nasal septum deviation" EXACT []
is_a: MP:0002239 ! abnormal nasal septum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T13:18:09Z" xsd:dateTime

[Term]
id: MP:0030200
name: abnormal nasal septum cartilage morphology
def: "any structural anomaly of the hyaline cartilage of the nasal septum that is somewhat quadrilateral in shape, thicker at its margins than at its center, and completes the separation between the nasal cavities" [https://en.wikipedia.org/wiki/Septal_nasal_cartilage, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal quadrangular cartilage morphology" EXACT []
synonym: "abnormal septal nasal cartilage morphology" EXACT []
is_a: MP:0002239 ! abnormal nasal septum morphology
is_a: MP:0031449 ! abnormal nasal cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T13:28:16Z" xsd:dateTime

[Term]
id: MP:0030201
name: absent nasal septum cartilage
def: "absence of the hyaline cartilage of the nasal septum that is somewhat quadrilateral in shape, thicker at its margins than at its center, and completes the separation between the nasal cavities" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent nasal septal cartilage" EXACT []
synonym: "absent quadrangular cartilage" EXACT []
synonym: "agenesis of the nasal septal cartilage" EXACT []
is_a: MP:0030200 ! abnormal nasal septum cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T13:46:35Z" xsd:dateTime

[Term]
id: MP:0030202
name: nasal septum cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the nasal septum cartilage, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic nasal septal cartilage" EXACT []
synonym: "hypoplastic nasal septum cartilage" EXACT []
synonym: "hypoplastic quadrangular cartilage" EXACT []
synonym: "nasal septal cartilage hypoplasia" EXACT []
is_a: MP:0030200 ! abnormal nasal septum cartilage morphology
is_a: MP:0031450 ! nasal cartilage hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T13:55:13Z" xsd:dateTime

[Term]
id: MP:0030203
name: short nasal septum
def: "reduced length of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nasal septum length" EXACT []
synonym: "reduced nasal septum length" EXACT []
synonym: "shortened nasal septum" EXACT []
is_a: MP:0030197 ! small nasal septum
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T14:02:30Z" xsd:dateTime

[Term]
id: MP:0030204
name: large nasal septum
def: "increased size of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged nasal septum" EXACT []
synonym: "increased nasal septum size" EXACT []
is_a: MP:0002239 ! abnormal nasal septum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T14:09:46Z" xsd:dateTime

[Term]
id: MP:0030205
name: thick nasal septum
def: "increased width of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [HP:0009746, https://orcid.org/0000-0002-6490-7723]
synonym: "broad nasal septum" EXACT []
synonym: "increased nasal septum width" EXACT []
synonym: "wide nasal septum" EXACT []
is_a: MP:0030204 ! large nasal septum
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T14:24:21Z" xsd:dateTime

[Term]
id: MP:0030206
name: thin nasal septum
def: "decreased width of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [HP:0009936, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased nasal septum width" EXACT []
synonym: "narrow nasal septum" EXACT []
synonym: "reduced nasal septum width" EXACT []
is_a: MP:0030197 ! small nasal septum
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-26T14:29:23Z" xsd:dateTime

[Term]
id: MP:0030207
name: absent zygomaticus muscle
def: "absence of the zygomaticus major and/or minor facial muscles that originate from the body of the zygoma and pass downwards to insert into the corner of the mouth and lateral aspect of the upper lip, respectively" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030040 ! absent facial muscle
is_a: MP:0030184 ! abnormal zygomaticus muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T05:55:11Z" xsd:dateTime

[Term]
id: MP:0030208
name: abnormal intrinsic tongue muscle morphology
def: "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://orcid.org/0000-0002-6490-7723, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue]
synonym: "abnormal intrinsic lingual muscle morphology" EXACT []
is_a: MP:0004136 ! abnormal tongue muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T07:38:50Z" xsd:dateTime

[Term]
id: MP:0030209
name: abnormal extrinsic tongue muscle morphology
def: "any structural anomaly of any of the four paired muscles that originate outside of and insert into the tongue and act to alter the position of the tongue, allowing for protrusion, retraction, and side-to-side movement; these muscles include the genioglossus, the hyoglossus (often including the chondroglossus), the styloglossus, and the palatoglossus" [https://en.wikipedia.org/wiki/Tongue, https://orcid.org/0000-0002-6490-7723, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue]
synonym: "abnormal extrinsic lingual muscle morphology" EXACT []
is_a: MP:0004136 ! abnormal tongue muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T08:10:03Z" xsd:dateTime

[Term]
id: MP:0030210
name: abnormal genioglossus muscle morphology
def: "any structural anomaly of the paired, fan-shaped extrinsic tongue muscle which forms the majority of the body of the tongue, arises from the mental spine of the mandible and inserts into the hyoid bone and the bottom of the tongue; its action protracts and depresses the tongue" [https://en.wikipedia.org/wiki/Genioglossus, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal genioglossal muscle morphology" EXACT []
synonym: "abnormal genioglossus morphology" EXACT []
is_a: MP:0030209 ! abnormal extrinsic tongue muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T09:37:50Z" xsd:dateTime

[Term]
id: MP:0030211
name: abnormal styloglossus muscle morphology
def: "any structural anomaly of the paired extrinsic tongue muscle that arises from the anterior surface of the styloid process of the mastoid bone and the proximal quarter of the stylohyoid ligament; it passes inferiorly and anteriorly to insert into the side and inferior aspects of the tongue; the muscle fibers of styloglossus merge with those of the hyoglossus; its action aids to retract the tongue and draw up the sides of the tongue to create a trough for swallowing" [https://orcid.org/0000-0002-6490-7723, https://www.gpnotebook.co.uk/simplepage.cfm?ID=503709774]
synonym: "abnormal styloglossus morphology" EXACT []
is_a: MP:0030209 ! abnormal extrinsic tongue muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T09:49:01Z" xsd:dateTime

[Term]
id: MP:0030212
name: abnormal hyoglossus muscle morphology
def: "any structural anomaly of the thin, quadrilateral extrinsic tongue muscle that arises from the side of the body and from the whole length of the greater cornu of the hyoid bone, and passes almost vertically upward to enter the side of the tongue, between the styloglossus and the inferior longitudinal muscle of the tongue; its action depresses and retracts the tongue and makes the dorsum more convex" [https://en.wikipedia.org/wiki/Hyoglossus, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hyoglossus morphology" EXACT []
is_a: MP:0030209 ! abnormal extrinsic tongue muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T09:57:57Z" xsd:dateTime

[Term]
id: MP:0030213
name: gonial bone hyperplasia
def: "increase in the number of normal cells in normal arrangement in the gonial bone, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic gonial bone" EXACT []
is_a: MP:0008383 ! enlarged gonial bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T10:16:56Z" xsd:dateTime

[Term]
id: MP:0030214
name: muscle fasciculation
def: "small, local, involuntary muscle contractions affecting a small number of muscle fibers, often causing a flicker of movement visible under the skin; fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron); this leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units" [HP:0002380, https://orcid.org/0000-0002-6490-7723]
synonym: "fasciculations" EXACT []
is_a: MP:0009046 ! muscle twitch
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T10:37:25Z" xsd:dateTime

[Term]
id: MP:0030215
name: facial muscle fasciculation
def: "fasciculations affecting the musculature of the face" [https://orcid.org/0000-0002-6490-7723]
synonym: "facial fasciculations" EXACT []
is_a: MP:0030214 ! muscle fasciculation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T10:59:02Z" xsd:dateTime

[Term]
id: MP:0030216
name: tongue muscle fasciculation
def: "fasciculations affecting the tongue muscle" [HP:0001308]
synonym: "lingual fasciculation" EXACT []
synonym: "lingual fasciculations" EXACT []
synonym: "lingual fibrillation" EXACT []
synonym: "lingual fibrillations" EXACT []
synonym: "lingual twitching" EXACT []
synonym: "tongue fasciculation" EXACT []
synonym: "tongue fasciculations" EXACT []
synonym: "tongue fibrillation" EXACT []
synonym: "tongue fibrillations" EXACT []
synonym: "tongue twitching" EXACT []
is_a: MP:0030214 ! muscle fasciculation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:03:01Z" xsd:dateTime

[Term]
id: MP:0030217
name: abnormal piriform aperture morphology
def: "any structural anomaly of the pear-shaped bony inlet comprising the most anterior and narrowest bony portion of the nasal airway, formed by the nasal and maxillary bones; the maxillary spines mark the inferior margin of the piriform aperture" [https://radiopaedia.org/articles/pyriform-aperture, PMID:17082934]
synonym: "abnormal anterior nasal aperture morphology" EXACT []
synonym: "abnormal pyriform aperture morphology" EXACT []
is_a: MP:0002233 ! abnormal nose morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:21:24Z" xsd:dateTime

[Term]
id: MP:0030218
name: piriform aperture stenosis
def: "abnormal narrowing or constriction of the pear-shaped bony inlet comprising the most anterior and narrowest bony portion of the nasal airway" [PMID:17082934]
comment: Congenital nasal pyriform aperture stenosis (CNPAS) is a rare cause of nasal airway obstruction that clinically mimics choanal atresia in a neonate. In choanal atresia, the posterior nasal cavity is obstructed by a bony or membranous plate. However, in CNPAS the anterior nasal cavity is narrowed but patent. {xref="https://www.birpublications.org/doi/10.1259/bjrcr.20150006"}
synonym: "anterior nasal aperture stenosis" EXACT []
synonym: "narrowed anterior nasal aperture" EXACT []
synonym: "narrowed piriform aperture" EXACT []
synonym: "narrowed pyriform aperture" EXACT []
synonym: "pyriform aperture stenosis" EXACT []
is_a: MP:0030217 ! abnormal piriform aperture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:25:40Z" xsd:dateTime

[Term]
id: MP:0030219
name: jaw cyst
def: "presence of one or more saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also non-epithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst; true jaw cysts are classified as odontogenic or non-odontogenic" [MESH:D007570, RDO:0005912]
synonym: "cystic jaw" EXACT []
synonym: "cystic jaws" EXACT []
synonym: "jaw cysts" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
is_a: MP:0031310 ! abnormal cyst
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:37:32Z" xsd:dateTime

[Term]
id: MP:0030220
name: mandibular cyst
def: "presence of one or more saccular lesions lined with epithelium and contained within pathologically formed cavities in the mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic mandible" EXACT []
synonym: "lower jaw cyst" EXACT []
synonym: "lower jaw cysts" EXACT []
synonym: "mandibular cysts" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030219 ! jaw cyst
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:47:31Z" xsd:dateTime

[Term]
id: MP:0030221
name: maxillary cyst
def: "presence of one or more saccular lesions lined with epithelium and contained within pathologically formed cavities in the maxilla" [https://orcid.org/0000-0002-6490-7723]
synonym: "cystic maxilla" EXACT []
synonym: "maxillary cysts" EXACT []
synonym: "upper jaw cyst" EXACT []
synonym: "upper jaw cysts" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
is_a: MP:0030219 ! jaw cyst
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T11:57:23Z" xsd:dateTime

[Term]
id: MP:0030222
name: hyperostosis
def: "excessive growth or abnormal thickening of bone tissue; it may lead to exostosis" [HP:0100774, https://en.wikipedia.org/wiki/Hyperostosis]
synonym: "bone hypertrophy" EXACT []
synonym: "bone overgrowth" EXACT []
is_a: MP:0005508 ! abnormal skeleton morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T12:24:38Z" xsd:dateTime

[Term]
id: MP:0030223
name: mandibular hyperostosis
def: "hyperostosis (bony overgrowth) of the mandible" [HP:0004472]
synonym: "excessive growth of mandibular bone" BROAD []
synonym: "hyperostosis of lower jaw" EXACT []
synonym: "hyperostosis of mandibular bone" EXACT []
synonym: "increased ossification of lower jaw" RELATED []
synonym: "increased ossification of mandible" RELATED []
synonym: "increased ossification of mandibular bone" EXACT []
synonym: "overgrowth of mandibular bone" BROAD []
synonym: "thick lower jaw bone" BROAD []
synonym: "thick mandibular bone" BROAD []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030418 ! facial hyperostosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-09-28T13:10:38Z" xsd:dateTime

[Term]
id: MP:0030224
name: abnormal soft palate muscle morphology
def: "any structural anomaly of any of the five paired muscles of the soft palate that play important roles in swallowing and breathing; these muscles include the tensor veli palatini, palatoglossus, palatopharyngeus, levator veli palatini, and the musculus uvulae muscles" [https://en.wikipedia.org/wiki/Soft_palate, https://radiopaedia.org/articles/muscles-of-the-soft-palate]
synonym: "abnormal palatal muscle morphology" BROAD []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0003154 ! abnormal soft palate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T08:44:53Z" xsd:dateTime

[Term]
id: MP:0030225
name: abnormal cranial vertex morphology
def: "any structural anomaly of the midline bony landmark at the most superior part of the calvaria, near the midpoint of the sagittal suture (i.e. between the bregma and lambda)" [https://radiopaedia.org/articles/vertex]
synonym: "abnormal head vertex morphology" RELATED []
synonym: "abnormal skull vertex morphology" RELATED []
synonym: "abnormal vertex morphology" RELATED []
synonym: "abnormalities of the top of the head" BROAD []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T10:02:54Z" xsd:dateTime

[Term]
id: MP:0030226
name: middle ear polyps
def: "development of numerous growths that are connected to and protrude from the mucous membrane of the middle ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "middle ear polyposis" EXACT []
is_a: MP:0000049 ! abnormal middle ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T10:15:37Z" xsd:dateTime

[Term]
id: MP:0030227
name: abnormal tubotympanic recess morphology
def: "any structural morphology of the elongate recess derived from the first pharyngeal pouch; its distal part contributes to the formation of the tympanic membrane, its proximal part elongates to form the auditory tube, and its cavity gives rise to the tympanic cavity and mastoid antrum" [http://medicine.academic.ru/156417/tubotympanic_recess, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000049 ! abnormal middle ear morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T10:26:13Z" xsd:dateTime

[Term]
id: MP:0030228
name: absent tubotympanic recess
def: "absence of the elongate recess derived from the first pharyngeal pouch; its distal part contributes to the formation of the tympanic membrane, its proximal part elongates to form the auditory tube, and its cavity gives rise to the tympanic cavity and mastoid antrum" [http://medicine.academic.ru/156417/tubotympanic_recess, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030227 ! abnormal tubotympanic recess morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T10:34:40Z" xsd:dateTime

[Term]
id: MP:0030229
name: abnormal craniofacial suture morphology
def: "any structural anomaly of any of the dense, fibrous connective tissue joints between cranial and/or facial bones" [GO:0097094, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal craniofacial sutures" BROAD []
is_a: MP:0002116 ! abnormal craniofacial bone morphology
is_a: MP:0030878 ! abnormal fibrous joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T10:44:32Z" xsd:dateTime

[Term]
id: MP:0030230
name: abnormal facial suture morphology
def: "any structural anomaly of any of the dense, fibrous connective tissue joints between facial bones" [GO:0097096, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal facial sutures" BROAD []
is_a: MP:0005274 ! abnormal viscerocranium morphology
is_a: MP:0030229 ! abnormal craniofacial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T11:05:07Z" xsd:dateTime

[Term]
id: MP:0030231
name: abnormal zygomaticomaxillary suture morphology
def: "any structural anomaly of the suture between the zygomatic process of the maxilla and the maxillary margin of the zygomatic bone" [https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/zygomaticomaxillary-suture]
is_a: MP:0030230 ! abnormal facial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T11:44:11Z" xsd:dateTime

[Term]
id: MP:0030232
name: abnormal mandibular canal morphology
def: "any structural anomaly of the canal located within the internal aspect of the mandible which contains the inferior alveolar nerve, artery and the vein; it starts at the mandibular foramen, on the lingual side of the ramus, continues on the buccal surface of the body of the mandible, and ends at the mental foramen" [http://medical-dictionary.thefreedictionary.com/mandibular+canal, https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/mandibular-canal-1]
synonym: "abnormal inferior dental canal morphology" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T11:59:15Z" xsd:dateTime

[Term]
id: MP:0030233
name: absent mandibular canal
def: "absence of the canal that is normally located within the internal aspect of the mandible and contains the inferior alveolar nerve, artery and the vein" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent inferior dental canal" EXACT []
is_a: MP:0030232 ! abnormal mandibular canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T12:03:41Z" xsd:dateTime

[Term]
id: MP:0030234
name: abnormal mandibular foramen morphology
def: "any structural anomaly of the opening located on the medial surface of the ramus of the mandible that is the entrance to the mandibular canal; it transmits the inferior alveolar nerve, a branch of the posterior division of the mandibular division of the trigeminal nerve that supplies all the ipsilateral teeth up to the midline" [https://radiopaedia.org/articles/mandibular-foramen-1]
synonym: "abnormal inferior alveolar foramen morphology" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T12:18:48Z" xsd:dateTime

[Term]
id: MP:0030235
name: absent mandibular foramen
def: "absence of the opening that is normally located on the medial surface of the ramus of the mandible and forms the entrance to the mandibular canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent inferior alveolar foramen" EXACT []
is_a: MP:0030234 ! abnormal mandibular foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T12:25:56Z" xsd:dateTime

[Term]
id: MP:0030236
name: abnormal mental foramen morphology
def: "any structural anomaly of the small opening located on the anterior surface of the mandible; the mental nerve, a terminal branch of inferior alveolar nerve, and the mental artery leave the mandibular canal through it" [https://radiopaedia.org/articles/mental-foramen-1]
synonym: "abnormal mental foramina morphology" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T12:34:14Z" xsd:dateTime

[Term]
id: MP:0030237
name: absent mental foramen
def: "absence of the small opening located on the anterior surface of the mandible; normally, the mental nerve, a terminal branch of inferior alveolar nerve, and the mental artery leave the mandibular canal through it" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent mental foramina" EXACT []
is_a: MP:0030236 ! abnormal mental foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T12:40:58Z" xsd:dateTime

[Term]
id: MP:0030238
name: abnormal extraocular muscle development
def: "any anomaly in the differentiation of any of the striated muscles that are located within the orbit but are extrinsic and separate from the eyeball and control the movements of the eyeball and the superior eyelid; these include the superior rectus, inferior rectus, medial rectus, lateral rectus, inferior oblique, superior oblique, and levator palpebrae superioris" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal extra-ocular muscle development" EXACT []
is_a: MP:0003818 ! abnormal eye muscle development
is_a: MP:0005247 ! abnormal extraocular muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T13:36:23Z" xsd:dateTime

[Term]
id: MP:0030239
name: abnormal intraocular muscle development
def: "any anomaly in the differentiation of any of the smooth muscles located within the eye" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal intra-ocular muscle development" EXACT []
is_a: MP:0003687 ! abnormal intraocular muscle morphology
is_a: MP:0003818 ! abnormal eye muscle development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T13:41:10Z" xsd:dateTime

[Term]
id: MP:0030240
name: abnormal suprahyoid muscle morphology
def: "any structural anomaly of any of the four muscles located above the hyoid bone in the neck; these muscles include the digastric, stylohyoid, geniohyoid, and mylohyoid muscles and are all pharyngeal muscles, with the exception of the geniohyoid muscle; they have different actions but in general assist in elevating the hyoid bone and widening the esophagus during swallowing" [https://en.wikipedia.org/wiki/Suprahyoid_muscles]
synonym: "suprahyoid muscle dysplasia" NARROW []
is_a: MP:0002253 ! abnormal pharyngeal muscle morphology
property_value: dc:date "2017-10-03T14:20:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0030241
name: absent optic pit
def: "absence of either or both of the two pits that appear bilaterally in the region destined to become the forebrain as the cranial neural folds fuse; these optic pits or sulci continue to deepen laterally and bulge from the two sides of the forebrain to become the optic vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent optic pits" EXACT []
synonym: "absent optic sulci" EXACT []
synonym: "absent optic sulcus" EXACT []
is_a: MP:0012155 ! abnormal optic pit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T15:29:44Z" xsd:dateTime

[Term]
id: MP:0030242
name: small optic pit
def: "reduced size of either or both of the two pits that appear bilaterally in the region destined to become the forebrain as the cranial neural folds fuse; these optic pits or sulci continue to deepen laterally and bulge from the two sides of the forebrain to become the optic vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased optic pit size" EXACT []
synonym: "decreased optic sulcus size" EXACT []
synonym: "reduced optic pit size" EXACT []
synonym: "reduced optic sulcus size" EXACT []
synonym: "small optic pits" EXACT []
synonym: "small optic sulci" EXACT []
synonym: "small optic sulcus" EXACT []
is_a: MP:0012155 ! abnormal optic pit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-03T15:39:13Z" xsd:dateTime

[Term]
id: MP:0030243
name: abnormal chin morphology
def: "any structural anomaly of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw" [https://elementsofmorphology.nih.gov/anatomy-head_face.shtml, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal mental region morphology" EXACT []
synonym: "abnormal mentum morphology" RELATED []
synonym: "chin abnormalities" BROAD []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0003743 ! abnormal facial morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T07:38:52Z" xsd:dateTime

[Term]
id: MP:0030244
name: short chin
def: "decreased vertical dimension of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw" [https://elementsofmorphology.nih.gov/anatomy-head_face.shtml, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased chin height" EXACT []
synonym: "decreased chin length" EXACT []
synonym: "reduced chin height" EXACT []
synonym: "reduced chin length" EXACT []
synonym: "short mentum" RELATED []
synonym: "shortened chin" EXACT []
synonym: "vertical deficiency of chin" EXACT []
is_a: MP:0030243 ! abnormal chin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T07:51:51Z" xsd:dateTime

[Term]
id: MP:0030245
name: round head
def: "overall shape of the head is more circular than usual as viewed from the front" [https://orcid.org/0000-0002-6490-7723]
synonym: "circular head" EXACT []
synonym: "round head shape" EXACT []
synonym: "rounded head" EXACT []
is_a: MP:0011495 ! abnormal head shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T08:02:22Z" xsd:dateTime

[Term]
id: MP:0030246
name: abnormal cheek morphology
def: "any anomaly of the cheek - one of two bilateral soft tissue structures located in the midface region between the zygoma and the mandible" [PMID:19125436]
synonym: "cheek abnormalities" BROAD []
is_a: MP:0030095 ! abnormal midface morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T08:13:27Z" xsd:dateTime

[Term]
id: MP:0030247
name: prominent cheeks
def: "increased prominence or roundness of the soft tissues between the zygomata and the mandible" [HP:0000293, https://orcid.org/0000-0002-6490-7723]
synonym: "pronounced cheeks" EXACT []
is_a: MP:0030246 ! abnormal cheek morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T08:28:11Z" xsd:dateTime

[Term]
id: MP:0030248
name: narrow maxilla
def: "reduced width of the upper bony framework of the mouth where the superior teeth are held" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased breadth of the maxilla" EXACT []
synonym: "decreased breadth of the upper jaw bone" EXACT []
synonym: "decreased maxillary breadth" EXACT []
synonym: "decreased maxillary width" EXACT []
synonym: "decreased transverse dimension of the maxilla" EXACT []
synonym: "decreased width of the maxilla" EXACT []
synonym: "decreased width of the upper jaw bone" EXACT []
synonym: "narrow upper jaw bone" EXACT []
synonym: "reduced breadth of the maxilla" EXACT []
synonym: "reduced breadth of the upper jaw bone" EXACT []
synonym: "reduced maxillary breadth" EXACT []
synonym: "reduced maxillary width" EXACT []
synonym: "reduced transverse dimension of the maxilla" EXACT []
synonym: "reduced width of the maxilla" EXACT []
synonym: "reduced width of the upper jaw bone" EXACT []
is_a: MP:0004540 ! small maxilla
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T09:55:31Z" xsd:dateTime

[Term]
id: MP:0030249
name: small frontonasal prominence
def: "reduced size of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased frontonasal prominence size" EXACT []
synonym: "reduced frontonasal prominence size" EXACT []
synonym: "small forebrain process" EXACT []
synonym: "small forebrain prominence" EXACT []
synonym: "small frontonasal mass" EXACT []
synonym: "small frontonasal process" EXACT []
is_a: MP:0009901 ! abnormal frontonasal prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T10:06:34Z" xsd:dateTime

[Term]
id: MP:0030250
name: frontonasal prominence hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the frontonasal prominence, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic forebrain process" EXACT []
synonym: "hypoplastic forebrain prominence" EXACT []
synonym: "hypoplastic frontonasal mass" EXACT []
synonym: "hypoplastic frontonasal process" EXACT []
synonym: "hypoplastic frontonasal prominence" EXACT []
is_a: MP:0030249 ! small frontonasal prominence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T10:11:27Z" xsd:dateTime

[Term]
id: MP:0030251
name: broad frontonasal prominence
def: "increased width of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad forebrain process" EXACT []
synonym: "broad forebrain prominence" EXACT []
synonym: "broad frontonasal mass" EXACT []
synonym: "broad frontonasal process" EXACT []
synonym: "wide forebrain process" EXACT []
synonym: "wide forebrain prominence" EXACT []
synonym: "wide frontonasal mass" EXACT []
synonym: "wide frontonasal process" EXACT []
synonym: "wide frontonasal prominence" EXACT []
is_a: MP:0009901 ! abnormal frontonasal prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T10:15:16Z" xsd:dateTime

[Term]
id: MP:0030252
name: narrow frontonasal prominence
def: "decreased width of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow forebrain process" EXACT []
synonym: "narrow forebrain prominence" EXACT []
synonym: "narrow frontonasal mass" EXACT []
synonym: "narrow frontonasal process" EXACT []
is_a: MP:0030249 ! small frontonasal prominence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T10:20:25Z" xsd:dateTime

[Term]
id: MP:0030253
name: vertical orbital dystopia
def: "the orbits do not lie on the same horizontal plane, that is, one eye is lower than the other" [HP:0030867]
synonym: "eyes at different heights" EXACT []
synonym: "misaligned eyes" EXACT []
synonym: "unequal eye height" EXACT []
synonym: "uneven eyes" EXACT []
synonym: "vertical misalignment of the orbits" EXACT []
is_a: MP:0001299 ! abnormal eye distance/ position
is_a: MP:0010030 ! abnormal orbit morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T10:31:00Z" xsd:dateTime

[Term]
id: MP:0030254
name: abnormal dental arch morphology
def: "any structural anomaly of either of the two arches (crescent arrangements) of teeth, one on each jaw, that together constitute the dentition" [https://en.wikipedia.org/wiki/Dental_arch]
is_a: MP:0000454 ! abnormal jaw morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:16:00Z" xsd:dateTime

[Term]
id: MP:0030255
name: abnormal maxillary dental arch morphology
def: "any structural anomaly of the dental arch formed by the teeth of the maxilla (upper jaw bone)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal superior dental arch morphology" EXACT []
synonym: "abnormal upper dental arch morphology" EXACT []
is_a: MP:0030254 ! abnormal dental arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:21:04Z" xsd:dateTime

[Term]
id: MP:0030256
name: abnormal mandibular dental arch morphology
def: "any structural anomaly of the dental arch formed by the teeth of the mandible (lower jaw bone)" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal inferior dental arch morphology" EXACT []
synonym: "abnormal lower dental arch morphology" EXACT []
is_a: MP:0030254 ! abnormal dental arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:25:00Z" xsd:dateTime

[Term]
id: MP:0030257
name: increased tongue papilloma incidence
def: "greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in the tongue" [https://orcid.org/0000-0002-6490-7723]
synonym: "lingual papilloma" RELATED []
synonym: "tongue papilloma" RELATED []
is_a: MP:0003752 ! increased oral papilloma incidence
is_a: MP:0010272 ! increased tongue tumor incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:34:09Z" xsd:dateTime

[Term]
id: MP:0030258
name: small mandibular condyloid process
def: "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular condyloid process size" EXACT []
synonym: "reduced mandibular condyloid process size" EXACT []
synonym: "small mandibular condylar process" EXACT []
is_a: MP:0004595 ! abnormal mandibular condyloid process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:50:41Z" xsd:dateTime

[Term]
id: MP:0030259
name: mandibular condyloid process hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mandibular condyloid process, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic mandibular condylar process" EXACT []
synonym: "hypoplastic mandibular condyloid process" EXACT []
synonym: "mandibular condylar process hypoplasia" EXACT []
is_a: MP:0030258 ! small mandibular condyloid process
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T11:58:49Z" xsd:dateTime

[Term]
id: MP:0030260
name: abnormal palatomaxillary suture morphology
def: "any structural anomaly of the transverse suture across the back of the hard palate that separates the maxillary shelf of the palate from the horizontal plates of the palatine bones" [http://www.anatomyexpert.com/app/structure/1685/980/]
synonym: "abnormal sutura palatomaxillaris morphology" RELATED []
is_a: MP:0030230 ! abnormal facial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T12:25:24Z" xsd:dateTime

[Term]
id: MP:0030261
name: abnormal temporal bone zygomatic process morphology
def: "any structural anomaly of the long, arched process that projects from the lower region of the squamous part of the temporal bone and articulates with the zygomatic bone; this process is at first directed lateralward, its two surfaces looking upward and downward; it then appears as if twisted inward upon itself, and runs forward, its surfaces now looking medialward and lateralward" [https://en.wikipedia.org/wiki/Zygomatic_process_of_temporal_bone]
synonym: "abnormal temporal zygomatic process morphology" EXACT []
synonym: "abnormal zygomatic process of temporal bone morphology" EXACT []
is_a: MP:0005272 ! abnormal temporal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-06T13:10:15Z" xsd:dateTime

[Term]
id: MP:0030262
name: frontal bossing
def: "bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline; this is not the same as prominent forehead" [HP:0002007, PMID:19125436]
synonym: "frontal protuberance" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology
is_a: MP:0030045 ! abnormal forehead shape
is_a: MP:0030263 ! cranial bossing
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T06:38:47Z" xsd:dateTime

[Term]
id: MP:0030263
name: cranial bossing
def: "abnormal prominence or protrusion of various bones of the skull; most often occurs in the frontal bones beneath the forehead" [https://en.wikipedia.org/wiki/Skull_bossing]
synonym: "skull bossing" EXACT []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T09:16:20Z" xsd:dateTime

[Term]
id: MP:0030264
name: occipital bossing
def: "an area of marked prominence or protrusion in the occipital region at the back of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "bossing of the occipital bone" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology
is_a: MP:0030263 ! cranial bossing
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T09:21:17Z" xsd:dateTime

[Term]
id: MP:0030265
name: parietal bossing
def: "an area of marked prominence or protrusion in the parietal region" [HP:0004641, https://orcid.org/0000-0002-6490-7723]
synonym: "bossing of the parietal bone" EXACT []
is_a: MP:0000109 ! abnormal parietal bone morphology
is_a: MP:0030263 ! cranial bossing
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T09:47:57Z" xsd:dateTime

[Term]
id: MP:0030266
name: small vomer bone
def: "reduced size of the triangular flat bone of the nasal septum" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased vomer bone size" EXACT []
synonym: "reduced vomer bone size" EXACT []
is_a: MP:0000098 ! abnormal vomer bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T10:01:55Z" xsd:dateTime

[Term]
id: MP:0030267
name: decreased basicranium angle
def: "a decrease in the expected angle formed by a line representing the floor of the anterior cranial fossa intersecting a line representing the axis of the clivus of the base of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased basicranial angle" EXACT []
synonym: "decreased cranial base angle" EXACT []
synonym: "reduced basicranial angle" EXACT []
synonym: "reduced basicranium angle" EXACT []
synonym: "reduced cranial base angle" EXACT []
synonym: "small basicranial angle" EXACT []
synonym: "small basicranium angle" EXACT []
synonym: "small cranial base angle" EXACT []
is_a: MP:0009782 ! abnormal basicranium angle
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T10:15:43Z" xsd:dateTime

[Term]
id: MP:0030268
name: agnathia
def: "congenital, complete or partial, absence of one or both jaws; total absence of the maxilla and/or mandible is extremely rare in mammals; when agnathia occurs, it may be combined with cyclopia or synotia" [https://mdefine.org/a/agnathia-37b.html]
synonym: "absent jaw" EXACT []
synonym: "absent jaws" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T10:34:59Z" xsd:dateTime

[Term]
id: MP:0030269
name: absent mandibular ramus
def: "absence of the upturned perpendicular extremity of the mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent mandible ramus" EXACT []
synonym: "missing mandible ramus" EXACT []
synonym: "missing mandibular ramus" EXACT []
is_a: MP:0010150 ! abnormal mandibular ramus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T11:15:05Z" xsd:dateTime

[Term]
id: MP:0030270
name: retrogenia
def: "abnormal posterior-shifted positioning of the chin in relation to the rest of the facial skeleton; occlusion is normal" [http://www.oxfordreference.com/view/10.1093/oi/authority.20110803100416924, https://www2.aofoundation.org/wps/portal/surgerymobile?contentUrl=/srg/95b/01-Diagnosis/D300-ChinSagittal.jsp&soloState=precomp&title=&Language=en]
synonym: "receding chin" EXACT []
synonym: "recessed chin" EXACT []
is_a: MP:0030243 ! abnormal chin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T11:40:14Z" xsd:dateTime

[Term]
id: MP:0030271
name: abnormal foramen rotundum morphology
def: "any structural anomaly of the circular aperture (foramen) located in the middle cranial fossa, inferomedial to the superior orbital fissure at the base of greater wing of sphenoid; its medial border is formed by the lateral wall of the sphenoid sinus; it runs downwards and laterally in an oblique path and joins the middle cranial fossa with the pterygopalatine fossa; it transmits the maxillary branch of trigeminal nerve, artery of foramen rotundum, and emissary veins" [https://radiopaedia.org/articles/foramen-rotundum]
synonym: "abnormal foramen rotundum of the skull" EXACT []
synonym: "abnormal foramen rotundum ossis sphenoidalis" EXACT []
synonym: "abnormal round foramen morphology" EXACT []
is_a: MP:0000104 ! abnormal sphenoid bone morphology
is_a: MP:0030308 ! abnormal middle cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T11:54:28Z" xsd:dateTime

[Term]
id: MP:0030272
name: abnormal cranial foramen ovale morphology
def: "any structural anomaly of the oval-shaped opening in the middle cranial fossa located at the posterior base of the greater wing of the sphenoid bone, lateral to the lingual; it transmits the mandibular division of the trigeminal nerve, accessory meningeal artery, emissary veins between the cavernous sinuses and pterygoid plexus, otic ganglion, and occasionally the nervus spinosus and lesser petrosal nerve" [https://radiopaedia.org/articles/foramen-ovale-skull]
synonym: "abnormal foramen ovale basis cranii" EXACT []
synonym: "abnormal foramen ovale cranii" EXACT []
is_a: MP:0000104 ! abnormal sphenoid bone morphology
is_a: MP:0030308 ! abnormal middle cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T12:45:31Z" xsd:dateTime

[Term]
id: MP:0030273
name: mandibular retrognathia
def: "abnormal posterior-shifted positioning of the lower jaw (mandible) relative to the facial skeleton and soft tissues" [https://orcid.org/0000-0002-6490-7723]
synonym: "mandibular retrognathism" EXACT []
synonym: "mandibular retroposition" EXACT []
synonym: "receding lower jaw" EXACT []
synonym: "receding mandible" EXACT []
synonym: "retrognathia of lower jaw" EXACT []
is_a: MP:0000458 ! abnormal mandible morphology
is_a: MP:0004282 ! retrognathia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T13:24:03Z" xsd:dateTime

[Term]
id: MP:0030274
name: maxillary retrognathia
def: "abnormal posterior-shifted positioning of the upper jaw (maxilla) relative to the facial skeleton and soft tissues" [https://orcid.org/0000-0002-6490-7723]
synonym: "maxillary retrognathism" EXACT []
synonym: "maxillary retroposition" EXACT []
synonym: "receding maxilla" EXACT []
synonym: "receding upper jaw" EXACT []
synonym: "retrognathia of upper jaw" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
is_a: MP:0004282 ! retrognathia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-11T13:28:53Z" xsd:dateTime

[Term]
id: MP:0030275
name: thin frontal bone
def: "reduced thickness of the single bone forming the forehead and roof of the eye orbit" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased frontal bone thickness" EXACT []
synonym: "reduced frontal bone thickness" EXACT []
synonym: "thinned frontal bone" EXACT []
is_a: MP:0004377 ! small frontal bone
is_a: MP:0030279 ! thin neurocranium
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T07:50:01Z" xsd:dateTime

[Term]
id: MP:0030276
name: anterior cranium occultum
def: "presence of an abnormal skin-covered gap in the front of the head, usually due to increased distance between the frontal bones" [PMID:20106874]
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T09:35:24Z" xsd:dateTime

[Term]
id: MP:0030277
name: thin interparietal bone
def: "reduced thickness of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased interparietal bone thickness" EXACT []
synonym: "reduced interparietal bone thickness" EXACT []
synonym: "thinned interparietal bone" EXACT []
is_a: MP:0004384 ! small interparietal bone
is_a: MP:0030279 ! thin neurocranium
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T09:41:37Z" xsd:dateTime

[Term]
id: MP:0030278
name: thick neurocranium
def: "increased thickness of the bones of the skull enclosing the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "calvarial thickening" EXACT []
synonym: "increased calvarial thickness" EXACT []
synonym: "increased thickness of the calvaria" EXACT []
synonym: "increased thickness of the calvarium" EXACT []
synonym: "increased thickness of the cranial vault" EXACT []
synonym: "increased thickness of the skull cap" EXACT []
synonym: "thick calvaria" EXACT []
synonym: "thick calvarium" EXACT []
synonym: "thick cranial bones" BROAD []
synonym: "thick cranial vault" EXACT []
synonym: "thickened calvarium" EXACT []
synonym: "thickened cranial vault" EXACT []
synonym: "thickened neurocranium" EXACT []
synonym: "thickened skull cap" EXACT []
synonym: "thickening of the calvaria" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T09:51:58Z" xsd:dateTime

[Term]
id: MP:0030279
name: thin neurocranium
def: "decreased thickness of the bones of the skull enclosing the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "calvarial thinning" EXACT []
synonym: "decreased calvarial thickness" EXACT []
synonym: "decreased thickness of the calvaria" EXACT []
synonym: "decreased thickness of the calvarium" EXACT []
synonym: "decreased thickness of the cranial vault" EXACT []
synonym: "decreased thickness of the skull cap" EXACT []
synonym: "thin calvaria" EXACT []
synonym: "thin calvarium" EXACT []
synonym: "thin cranial bones" BROAD []
synonym: "thin cranial vault" EXACT []
synonym: "thinned calvarium" EXACT []
synonym: "thinned cranial vault" EXACT []
synonym: "thinned neurocranium" EXACT []
synonym: "thinned skull cap" EXACT []
synonym: "thinning of the calvaria" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T10:06:11Z" xsd:dateTime

[Term]
id: MP:0030280
name: short parietal bone
def: "length reduction of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased parietal bone length" EXACT []
synonym: "reduced parietal bone length" EXACT []
synonym: "short parietal bones" EXACT []
is_a: MP:0004418 ! small parietal bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T10:56:18Z" xsd:dateTime

[Term]
id: MP:0030281
name: thin parietal bone
def: "reduced thickness of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased parietal bone thickness" EXACT []
synonym: "reduced parietal bone thickness" EXACT []
synonym: "thin parietal bones" EXACT []
is_a: MP:0004418 ! small parietal bone
is_a: MP:0030279 ! thin neurocranium
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T11:12:39Z" xsd:dateTime

[Term]
id: MP:0030282
name: broad supraoccipital bone
def: "increased width of the bone on the dorsal side of the great foramen of the skull, which usually forms a part of the occipital in the adult, but is distinct in the young" [https://orcid.org/0000-0002-6490-7723]
synonym: "broadened supraoccipital bone" EXACT []
synonym: "wide supraoccipital bone" EXACT []
synonym: "widened supraoccipital bone" EXACT []
is_a: MP:0000078 ! abnormal supraoccipital bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T11:37:06Z" xsd:dateTime

[Term]
id: MP:0030283
name: small mandibular coronoid process
def: "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular coronoid process size" EXACT []
synonym: "reduced mandibular coronoid process size" EXACT []
synonym: "small coronoid process of the mandible" EXACT []
synonym: "small mandible coronoid process" EXACT []
is_a: MP:0004594 ! abnormal mandibular coronoid process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T11:51:50Z" xsd:dateTime

[Term]
id: MP:0030284
name: short mandibular coronoid process
def: "length reduction or truncation of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular coronoid process length" EXACT []
synonym: "reduced mandibular coronoid process length" EXACT []
synonym: "short coronoid process of the mandible" EXACT []
synonym: "short mandible coronoid process" EXACT []
synonym: "truncated mandible coronoid process" EXACT []
synonym: "truncated mandibular coronoid process" EXACT []
is_a: MP:0030283 ! small mandibular coronoid process
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:06:10Z" xsd:dateTime

[Term]
id: MP:0030285
name: mandibular coronoid process hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mandibular coronoid process, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic coronoid process of the mandible" EXACT []
synonym: "hypoplastic mandible coronoid process" EXACT []
synonym: "hypoplastic mandibular coronoid process" EXACT []
is_a: MP:0030283 ! small mandibular coronoid process
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:12:21Z" xsd:dateTime

[Term]
id: MP:0030286
name: occipital bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the occipital bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic occipital bone" EXACT []
is_a: MP:0004441 ! small occipital bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:20:11Z" xsd:dateTime

[Term]
id: MP:0030287
name: enlarged occipital bone
def: "increased size of the bone at the lower, posterior part of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased occipital bone size" EXACT []
synonym: "large occipital bone" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:23:41Z" xsd:dateTime

[Term]
id: MP:0030288
name: broad occipital bone
def: "increased width of the bone at the lower, posterior part of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "broadened occipital bone" EXACT []
synonym: "wide occipital bone" EXACT []
synonym: "widened occipital bone" EXACT []
is_a: MP:0030287 ! enlarged occipital bone
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:27:02Z" xsd:dateTime

[Term]
id: MP:0030289
name: flat occipital bone
def: "abnormal flatness of the bone at the lower, posterior part of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "flattened occipital bone" EXACT []
is_a: MP:0005269 ! abnormal occipital bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-13T12:30:43Z" xsd:dateTime

[Term]
id: MP:0030290
name: absent soft palate
def: "absence of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent palatine velum" EXACT []
synonym: "absent velum" EXACT []
synonym: "absent velum palatinum" EXACT []
synonym: "agenesis of the soft palate" EXACT []
synonym: "aplasia of the soft palate" EXACT []
synonym: "missing palatine velum" EXACT []
synonym: "missing soft palate" EXACT []
synonym: "missing velum" EXACT []
synonym: "missing velum palatinum" EXACT []
synonym: "soft palate agenesis" EXACT []
synonym: "soft palate aplasia" EXACT []
is_a: MP:0003154 ! abnormal soft palate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T07:54:59Z" xsd:dateTime

[Term]
id: MP:0030291
name: short soft palate
def: "reduced length of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased soft palate length" EXACT []
synonym: "reduced soft palate length" EXACT []
synonym: "short palatine velum" EXACT []
synonym: "short velum" EXACT []
synonym: "short velum palatinum" EXACT []
synonym: "shortened soft palate" EXACT []
is_a: MP:0003154 ! abnormal soft palate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T08:02:02Z" xsd:dateTime

[Term]
id: MP:0030292
name: abnormal tensor veli palatini muscle morphology
def: "any structural anomaly of the broad, thin, ribbon-like muscle that tenses the soft palate" [https://en.wikipedia.org/wiki/Tensor_veli_palatini_muscle]
synonym: "abnormal musculus tensor veli palatini" RELATED []
synonym: "abnormal tensor muscle of the velum palatinum morphology" EXACT []
synonym: "abnormal tensor palati morphology" RELATED []
synonym: "abnormal tensor veli palatini morphology" EXACT []
is_a: MP:0030224 ! abnormal soft palate muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T09:05:21Z" xsd:dateTime

[Term]
id: MP:0030293
name: small tensor veli palatini muscle
def: "reduced size of the broad, thin, ribbon-like muscle that tenses the soft palate" [https://orcid.org/0000-0002-6490-7723]
synonym: "small musculus tensor veli palatini" RELATED []
synonym: "small tensor muscle of the velum palatinum" EXACT []
synonym: "small tensor palati" RELATED []
synonym: "small tensor veli palatini" EXACT []
is_a: MP:0030292 ! abnormal tensor veli palatini muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T09:15:12Z" xsd:dateTime

[Term]
id: MP:0030294
name: abnormal levator veli palatini muscle morphology
def: "any structural anomaly of the paired cylindrical muscle that forms a V-shaped sling behind and above the soft palate; it originates from the apex of the inferior surface of the petrous temporal bone and the medial rim of the auditory tube, and inserts into the palatine aponeurosis between the two heads of palatopharyngeus; it elevates and laterally deviates the soft palate; it also aids the tensor veli palatini in opening the auditory tube on swallowing to allow equalization of pressure between the middle ear and pharynx" [https://radiopaedia.org/articles/levator-veli-palatini]
synonym: "abnormal levator muscle of the soft palate morphology" EXACT []
synonym: "abnormal levator muscle of the velum palatinum morphology" EXACT []
synonym: "abnormal levator palati morphology" RELATED []
synonym: "abnormal levator veli morphology" EXACT []
synonym: "abnormal levator veli palatini morphology" EXACT []
synonym: "abnormal musculus levator veli palatini" RELATED []
is_a: MP:0030224 ! abnormal soft palate muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T09:21:20Z" xsd:dateTime

[Term]
id: MP:0030295
name: small levator veli palatini muscle
def: "reduced size of the paired cylindrical muscle that forms a V-shaped sling behind and above the soft palate; it originates from the apex of the inferior surface of the petrous temporal bone and the medial rim of the auditory tube, and inserts into the palatine aponeurosis between the two heads of palatopharyngeus; it elevates and laterally deviates the soft palate; it also aids the tensor veli palatini in opening the auditory tube on swallowing
 to allow equalization of pressure between the middle ear and pharynx" [https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/levator-veli-palatini]
synonym: "small levator muscle of the soft palate" EXACT []
synonym: "small levator muscle of the velum palatinum" EXACT []
synonym: "small levator palati" RELATED []
synonym: "small levator veli" EXACT []
synonym: "small levator veli palatini" EXACT []
synonym: "small musculus levator veli palatini" RELATED []
is_a: MP:0030294 ! abnormal levator veli palatini muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T09:31:31Z" xsd:dateTime

[Term]
id: MP:0030296
name: abnormal infraorbital foramen morphology
def: "any structural anomaly of either of a pair of external openings (foramina) in the maxillary bone of the skull located below the infraorbital margin of the orbit; it transmits the infraorbital artery and vein, and the infraorbital nerve, a branch of the maxillary nerve" [https://en.wikipedia.org/wiki/Infraorbital_foramen]
synonym: "abnormal foramen infraorbitale morphology" EXACT []
synonym: "abnormal infra-orbital foramen morphology" EXACT []
synonym: "abnormal infraorbital foramen of the maxilla morphology" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T09:54:56Z" xsd:dateTime

[Term]
id: MP:0030297
name: outer ear hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the outer ear, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "auricle hypoplasia" EXACT []
synonym: "auricular hypoplasia" EXACT []
synonym: "hypoplastic auricles" EXACT []
synonym: "hypoplastic ear pinnae" EXACT []
synonym: "hypoplastic external ear" EXACT []
synonym: "pinna hypoplasia" EXACT []
is_a: MP:0000018 ! small ears
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T10:03:23Z" xsd:dateTime

[Term]
id: MP:0030298
name: jaw transformation
def: "homeotic transformation of either jaw to adopt the fate of the other" [https://orcid.org/0000-0002-6490-7723]
synonym: "homeotic jaw transformation" EXACT []
synonym: "transformed jaw" BROAD []
is_a: MP:0000454 ! abnormal jaw morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T10:11:58Z" xsd:dateTime

[Term]
id: MP:0030299
name: lower jaw to upper jaw transformation
def: "homeotic transformation of lower jaw (mandibular) elements into upper jaw-like (maxillary) structures" [https://orcid.org/0000-0002-6490-7723, PMID:22560091]
synonym: "conversion from a mandibular to a maxillary phenotype" BROAD []
synonym: "homeotic transformation of the ventral jaw to a dorsal identity" EXACT []
is_a: MP:0030298 ! jaw transformation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T10:16:46Z" xsd:dateTime

[Term]
id: MP:0030300
name: upper jaw to lower jaw transformation
def: "homeotic transformation of upper jaw (maxillary) elements into lower jaw-like (mandibular) structures" [https://orcid.org/0000-0002-6490-7723, PMID:25725491]
synonym: "conversion from a maxillary to a mandibular phenotype" BROAD []
synonym: "homeotic transformation of the dorsal jaw to a ventral identity" EXACT []
is_a: MP:0030298 ! jaw transformation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T10:20:47Z" xsd:dateTime

[Term]
id: MP:0030301
name: abnormal maxillary frontal process morphology
def: "any structural anomaly of the upward extension from the body of the maxilla which articulates with the frontal bone; the frontal process has a vertical ridge which constitutes the medial border of the orbit (anterior lacrimal crest); posteriorly it forms the lacrimal groove together with the lacrimal bone; superomedially it is in close contact with the anterior ethmoidal sinuses" [http://www.medilexicon.com/dictionary/72273, https://www.kenhub.com/en/library/anatomy/the-maxilla]
synonym: "abnormal frontal process of the maxilla morphology" EXACT []
synonym: "abnormal maxilla frontal process morphology" EXACT []
synonym: "abnormal nasal process of the maxilla morphology" RELATED []
synonym: "abnormal processus frontalis maxillae moprhology" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T10:34:30Z" xsd:dateTime

[Term]
id: MP:0030302
name: abnormal maxillary zygomatic process morphology
def: "any structural anomaly of the rough triangular eminence situated at the angle of separation of the anterior, zygomatic, and orbital surfaces; in front, it forms part of the anterior surface; behind, it is concave, and forms part of the infratemporal fossa; above, it is rough and serrated for articulation with the zygomatic bone; below, it presents the prominent arched border which marks the division between the anterior and infratemporal surfaces" [https://en.wikipedia.org/wiki/Zygomatic_process_of_maxilla]
synonym: "abnormal malar process morphology" BROAD []
synonym: "abnormal malar process of the maxilla morphology" EXACT []
synonym: "abnormal maxilla zygomatic process morphology" EXACT []
synonym: "abnormal zygomatic process of the maxilla morphology" EXACT []
is_a: MP:0000455 ! abnormal maxilla morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-18T11:03:20Z" xsd:dateTime

[Term]
id: MP:0030303
name: small ethmoid bone
def: "reduced size of the single midline facial bone that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ethmoid bone size" EXACT []
synonym: "decreased ethmoidal bone size" EXACT []
synonym: "reduced ethmoid bone size" EXACT []
synonym: "reduced ethmoidal bone size" EXACT []
synonym: "small ethmoidal bone" EXACT []
is_a: MP:0000100 ! abnormal ethmoid bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T06:43:09Z" xsd:dateTime

[Term]
id: MP:0030304
name: abnormal cribriform plate morphology
def: "any structural anomaly of the sieve-like structure located between the anterior cranial fossa and the nasal cavity; it is a part of the ethmoid bone and supports the olfactory bulb, which lies in the olfactory fossa; it is perforated by foramina for the passage of the olfactory nerves and the anterior ethmoidal nerves to the upper part of the nasal septum, the latter of those to the superior nasal concha" [https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/cribriform-plate]
synonym: "abnormal cribriform plate of ethmoid bone morphology" EXACT []
synonym: "abnormal ethmoid bone cribriform plate morphology" EXACT []
synonym: "abnormal ethmoid bone lamina cribrosa morphology" EXACT []
synonym: "abnormal horizontal lamina of ethmoid bone morphology" EXACT []
synonym: "abnormal horizontal plate of ethmoid bone morphology" EXACT []
synonym: "abnormal lamina cribrosa ossis ethmoidalis morphology" EXACT []
is_a: MP:0000100 ! abnormal ethmoid bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T06:56:12Z" xsd:dateTime

[Term]
id: MP:0030305
name: small cribriform plate
def: "reduced size of the sieve-like structure located between the anterior cranial fossa and the nasal cavity; it is a part of the ethmoid bone and supports the olfactory bulb, which lies in the olfactory fossa" [https://orcid.org/0000-0002-6490-7723]
synonym: "small ethmoid bone cribriform plate" EXACT []
synonym: "small ethmoid bone lamina cribrosa" EXACT []
synonym: "small horizontal lamina of ethmoid bone" EXACT []
synonym: "small horizontal plate of ethmoid bone" EXACT []
synonym: "small lamina cribrosa ossis ethmoidalis" EXACT []
is_a: MP:0030304 ! abnormal cribriform plate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T07:10:37Z" xsd:dateTime

[Term]
id: MP:0030306
name: abnormal cranial fossa morphology
def: "any structural anomaly of any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity; each cranial fossa accommodates a different part of the brain" [https://www.merriam-webster.com/medical/cranial%20fossa]
synonym: "abnormal cranial fossae morphology" EXACT []
is_a: MP:0010029 ! abnormal basicranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T09:32:03Z" xsd:dateTime

[Term]
id: MP:0030307
name: abnormal anterior cranial fossa
def: "any structural anomaly of the depression in the floor of the cranial base which houses the projecting frontal lobes of the brain; it is formed by the orbital plates of the frontal, the cribriform plate of the ethmoid, and the small wings and front part of the body of the sphenoid; it is limited behind by the posterior borders of the small wings of the sphenoid and by the anterior margin of the chiasmatic groove; the lesser wings of the sphenoid separate the anterior and middle fossae" [https://en.wikipedia.org/wiki/Anterior_cranial_fossa]
synonym: "abnormal anterior fossa morphology" BROAD []
synonym: "abnormal fossa cranii anterior morphology" EXACT []
is_a: MP:0030306 ! abnormal cranial fossa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T09:40:21Z" xsd:dateTime

[Term]
id: MP:0030308
name: abnormal middle cranial fossa morphology
def: "any structural anomaly of the butterfly-shaped depression which is centrally located in the cranial floor, narrow in the middle and wider laterally, and houses the temporal lobes of the cerebrum and the pituitary gland; it is separated from the posterior fossa by the clivus and the petrous crest; it is bounded: in front, by the posterior margins of the lesser wings of the sphenoid bone, the anterior clinoid processes, and the ridge forming the anterior margin of the chiasmatic groove; behind, by the superior angles of the petrous portions of the temporal bones and the dorsum sellae; laterally, by the temporal squamae, sphenoidal angles of the parietals, and greater wings of the sphenoid; it is traversed by the squamosal, sphenoparietal, sphenosquamosal, and sphenopetrosal sutures" [http://teachmeanatomy.info/head/areas/cranial-fossa/middle/, https://en.wikipedia.org/wiki/Middle_cranial_fossa, https://radiopaedia.org/articles/middle-cranial-fossa]
synonym: "abnormal fossa cranii media morphology" EXACT []
synonym: "abnormal middle fossa morphology" BROAD []
is_a: MP:0030306 ! abnormal cranial fossa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T10:01:28Z" xsd:dateTime

[Term]
id: MP:0030309
name: abnormal posterior cranial fossa morphology
def: "any structural anomaly of the most inferior and deepest of the cranial fossae, located between the foramen magnum and tentorium cerebelli, which houses the brainstem and cerebellum; it is bounded anteriorly and medially by the dorsum sellae of the sphenoid bone; anteriorly and laterally by the superior border of the petrous part of the temporal bone; and posteriorly by the internal surface of the squamous part of the occipital bone; its floor consists of the mastoid part of the temporal bone and the squamous, condylar and basilar parts of the occipital bone" [http://teachmeanatomy.info/head/areas/cranial-fossa/posterior/, https://radiopaedia.org/articles/posterior-cranial-fossa]
synonym: "abnormal fossa cranii posterior morphology" EXACT []
synonym: "abnormal posterior fossa morphology" BROAD []
is_a: MP:0030306 ! abnormal cranial fossa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T10:11:35Z" xsd:dateTime

[Term]
id: MP:0030310
name: abnormal cranial foramen morphology
def: "any structural anomaly of any of the openings or orifices (foramina) in the skull through which cranial nerves, arteries, veins and other structures pass into and out of the cranium" [https://en.wikipedia.org/wiki/List_of_foramina_of_the_human_body, https://radiopaedia.org/articles/cranial-foramina]
synonym: "abnormal cranial foramina morphology" EXACT []
synonym: "abnormal foramina of the skull" BROAD []
synonym: "abnormal skull foramen morphology" EXACT []
synonym: "abnormal skull foramina morphology" EXACT []
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T10:34:02Z" xsd:dateTime

[Term]
id: MP:0030311
name: abnormal mandibular fossa morphology
def: "any structural anomaly of the depression in the temporal bone that articulates with the mandible; it is a part of the temporomandibular joint and lodges the condyle of the mandible; in the temporal bone, the mandibular fossa is bounded anteriorly by the articular tubercle and posteriorly by the tympanic portion of the temporal bone, which separates it from the external acoustic meatus; the fossa is divided into two parts by a narrow slit, the petrotympanic fissure" [https://en.wikipedia.org/wiki/Mandibular_fossa, https://radiopaedia.org/articles/mandibular-fossa]
is_a: MP:0004423 ! abnormal temporal bone squamous part morphology
is_a: MP:0011210 ! abnormal temporomandibular joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-23T11:42:32Z" xsd:dateTime

[Term]
id: MP:0030312
name: enlarged pharyngeal arch
def: "increased size of one or more of the transient structures of the embryo that develop into regions of the head, neck and ears" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged branchial arch" EXACT []
synonym: "increased branchial arch size" EXACT []
synonym: "increased pharyngeal arch size" EXACT []
is_a: MP:0002884 ! abnormal pharyngeal arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T07:45:08Z" xsd:dateTime

[Term]
id: MP:0030313
name: abnormal face development
def: "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
synonym: "abnormal facial development" EXACT []
is_a: MP:0003743 ! abnormal facial morphology
is_a: MP:0012176 ! abnormal head development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T08:00:46Z" xsd:dateTime

[Term]
id: MP:0030314
name: absent primary palate
def: "missing the initial portion of the palate formed from the intermaxillary segment" [https://orcid.org/0000-0002-6490-7723, UBERON:0005620]
synonym: "absent primitive palate" EXACT []
is_a: MP:0013549 ! abnormal primary palate morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T10:29:32Z" xsd:dateTime

[Term]
id: MP:0030315
name: small neurocranium
def: "decreased size of the bones of the skull enclosing the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased neurocranium size" EXACT []
synonym: "reduced neurocranium size" EXACT []
synonym: "small calvaria" EXACT []
synonym: "small calvarium" EXACT []
synonym: "small cranial vault" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T10:44:18Z" xsd:dateTime

[Term]
id: MP:0030316
name: enlarged neurocranium
def: "increased size of the bones of the skull enclosing the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged calvaria" EXACT []
synonym: "enlarged calvarium" EXACT []
synonym: "enlarged cranial vault" EXACT []
synonym: "increased neurocranium size" EXACT []
synonym: "large calvaria" EXACT []
synonym: "large calvarium" EXACT []
synonym: "large cranial vault" EXACT []
is_a: MP:0000074 ! abnormal neurocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T11:14:56Z" xsd:dateTime

[Term]
id: MP:0030317
name: absent maxillary zygomatic process
def: "absence of the rough triangular eminence situated at the angle of separation of the anterior, zygomatic, and orbital surfaces; in front, it forms part of the anterior surface; behind, it is concave, and forms part of the infratemporal fossa; above, it is rough and serrated for articulation with the zygomatic bone; below, it presents the prominent arched border which marks the division between the anterior and infratemporal surfaces" [https://en.wikipedia.org/wiki/Zygomatic_process_of_maxilla, https://orcid.org/0000-0002-6490-7723]
synonym: "absent malar process" EXACT []
synonym: "absent maxilla zygomatic process" EXACT []
synonym: "absent processus zygomaticus maxillae" EXACT []
synonym: "absent zygomatic process of the maxilla" EXACT []
is_a: MP:0030302 ! abnormal maxillary zygomatic process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T12:04:45Z" xsd:dateTime

[Term]
id: MP:0030318
name: enlarged maxillary zygomatic process
def: "increased size of the rough triangular eminence situated at the angle of separation of the anterior, zygomatic, and orbital surfaces; in front, it forms part of the anterior surface; behind, it is concave, and forms part of the infratemporal fossa; above, it is rough and serrated for articulation with the zygomatic bone; below, it presents the prominent arched border which marks the division between the anterior and infratemporal surfaces" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged malar process" EXACT []
synonym: "enlarged maxilla zygomatic process" EXACT []
synonym: "enlarged processus zygomaticus maxillae" EXACT []
synonym: "enlarged zygomatic process of the maxilla" EXACT []
is_a: MP:0030302 ! abnormal maxillary zygomatic process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T12:08:38Z" xsd:dateTime

[Term]
id: MP:0030319
name: abnormal temporal bone petrous part morphology
def: "any structural anomaly of the dense, pyramid-shaped portion of the temporal bone that is wedged in at the base of the skull between the sphenoid and occipital bones; directed medially, forward, and a little upward, it presents a base, an apex, three surfaces, and three angles, and houses in its interior, the components of the inner ear; the petrous portion is among the most basal elements of the skull and forms part of the endocranium" [https://en.wikipedia.org/wiki/Petrous_part_of_the_temporal_bone]
synonym: "abnormal pars petrosa (os temporale) morphology" EXACT []
synonym: "abnormal pars petrosa ossis temporalis morphology" EXACT []
synonym: "abnormal petrosal bone morphology" EXACT []
synonym: "abnormal petrous bone morphology" EXACT []
synonym: "abnormal petrous temporal bone morphology" EXACT []
is_a: MP:0005272 ! abnormal temporal bone morphology
is_a: MP:0010029 ! abnormal basicranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T12:19:58Z" xsd:dateTime

[Term]
id: MP:0030320
name: abnormal temporal bone tympanic part morphology
def: "any structural anomaly of the curved plate of bone that is situated inferiorly to the squamous part and anteriorly to the mastoid part of the temporal bone; it surrounds the external auditory meatus, forming the anterior wall, floor and some of the posterior wall of the bony external acoustic meatus; its lateral border gives the attachment to the cartilaginous part of the external acoustic meatus; its anteroinferior surface forms the posterior boundary of the mandibular fossa" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone, https://radiopaedia.org/articles/tympanic-part-of-temporal-bone]
synonym: "abnormal pars tympanica (os temporale) morphology" EXACT []
synonym: "abnormal pars tympanica ossis temporalis morphology" EXACT []
synonym: "abnormal tympanic bone morphology" EXACT []
synonym: "abnormal tympanic plate morphology" EXACT []
is_a: MP:0005272 ! abnormal temporal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T12:49:24Z" xsd:dateTime

[Term]
id: MP:0030321
name: abnormal tegmen tympani morphology
def: "any structural anomaly of the thin plate of bone which separates the middle ear (tympanic) cavity from the dura of the middle cranial fossa and forms the roof of the middle ear cavity; it is formed in part by the petrous portion of the temporal bone, and the squamous portion of the temporal bone" [http://www.drtbalu.com/anat_middleear.html, https://medical-dictionary.thefreedictionary.com/tegmen+tympani]
is_a: MP:0030154 ! abnormal tympanic cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T13:17:15Z" xsd:dateTime

[Term]
id: MP:0030322
name: styloid process hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the styliod process, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic processus styloideus" EXACT []
synonym: "hypoplastic styloid process" EXACT []
synonym: "hypoplastic temporal bone styloid process" EXACT []
synonym: "hypoplastic temporal styloid process" EXACT []
is_a: MP:0008023 ! abnormal styloid process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T13:28:06Z" xsd:dateTime

[Term]
id: MP:0030323
name: short styloid process
def: "length reduction or truncation of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "short processus styloideus" EXACT []
synonym: "short temporal bone styloid process" EXACT []
synonym: "short temporal styloid process" EXACT []
synonym: "shortened styloid process" EXACT []
synonym: "truncated styloid process" EXACT []
is_a: MP:0008023 ! abnormal styloid process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-25T13:35:14Z" xsd:dateTime

[Term]
id: MP:0030324
name: abnormal anterior head development
def: "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012176 ! abnormal head development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T08:11:36Z" xsd:dateTime

[Term]
id: MP:0030325
name: abnormal periocular mesenchyme apoptosis
def: "change in the timing or the number of cells of the periocular mesenchyme undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0004054 ! abnormal periocular mesenchyme morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T08:32:35Z" xsd:dateTime

[Term]
id: MP:0030326
name: decreased periocular mesenchyme apoptosis
def: "reduction in the number of cells of the periocular mesenchyme undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced periocular mesenchyme apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0030325 ! abnormal periocular mesenchyme apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T08:39:07Z" xsd:dateTime

[Term]
id: MP:0030327
name: temporomandibular joint ankylosis
def: "fusion or adherence of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening; true ankylosis may be bony or fibrous; in bony ankylosis, the condyle or ramus is attached to the temporal or zygomatic bone by an osseous bridge; in fibrous ankylosis a soft tissue (fibrous) union of joint components occurs while the bone components appear normal" [HP:0012478, http://www.journalofdentofacialsciences.com/journal/vol2_issue4/Article9_Manojmeena.pdf]
synonym: "fusion of the jaw joint" EXACT []
synonym: "temporomandibular joint fusion" EXACT []
synonym: "TMJ ankylosis" EXACT []
is_a: MP:0011210 ! abnormal temporomandibular joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T09:09:12Z" xsd:dateTime

[Term]
id: MP:0030328
name: glossopalatal ankylosis
def: "presence of an intraoral band of variable thickness attaching the tongue to the hard palate or maxillary alveolar ridge" [http://www.tandfonline.com/doi/pdf/10.1080/22201181.2014.979629, PMID:23997492]
synonym: "ankyloglossia superior" EXACT []
synonym: "glossopalatal fusion" EXACT []
synonym: "glossopalatine ankylosis" EXACT []
synonym: "glossopalatine fusion" EXACT []
synonym: "palatoglossal adhesion" EXACT []
synonym: "palatoglossal fusion" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T11:06:10Z" xsd:dateTime

[Term]
id: MP:0030329
name: absent temporal bone petrous part
def: "absence of the dense, pyramid-shaped portion of the temporal bone that is wedged in at the base of the skull between the sphenoid and occipital bones; directed medially, forward, and a little upward, it presents a base, an apex, three surfaces, and three angles, and houses in its interior, the components of the inner ear; the petrous portion is among the most basal elements of the skull and forms part of the endocranium" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent pars petrosa (os temporale)" EXACT []
synonym: "absent pars petrosa ossis temporalis" EXACT []
synonym: "absent petrosal bone" EXACT []
synonym: "absent petrous bone" EXACT []
synonym: "absent petrous temporal bone" EXACT []
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T11:16:16Z" xsd:dateTime

[Term]
id: MP:0030330
name: abnormal temporomandibular joint disk morphology
def: "any structural anomaly of the oval, biconcave, avascular fibrocartilaginous structure located between the condyle of the mandible and the mandibular (glenoid) fossa of the temporal bone; the disk provides the gliding surface for the mandibular condyle, resulting in smooth joint movement; it splits the temporomandibular joint into two synovial joint cavities, each lined by a synovial membrane, and separates translational and rotational motion" [http://teachmeanatomy.info/head/joints/temporomandibular/, https://radiopaedia.org/articles/temporomandibular-joint-disc, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147437/]
synonym: "abnormal articular disk of temporomandibular joint morphology" EXACT []
synonym: "abnormal temporomandibular articular disc morphology" EXACT []
synonym: "abnormal temporomandibular articular disk morphology" EXACT []
synonym: "abnormal temporomandibular joint disc morphology" EXACT []
synonym: "abnormal temporomandibular joint meniscus morphology" EXACT []
synonym: "abnormal TMJ disc morphology" EXACT []
synonym: "abnormal TMJ disk morphology" EXACT []
is_a: MP:0011210 ! abnormal temporomandibular joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T11:45:36Z" xsd:dateTime

[Term]
id: MP:0030331
name: absent temporomandibular joint disk
def: "missing the oval, biconcave, avascular fibrocartilaginous structure located between the condyle of the mandible and the mandibular (glenoid) fossa of the temporal bone; the disk provides the gliding surface for the mandibular condyle, resulting in smooth joint movement; it splits the temporomandibular joint into two synovial joint cavities, each lined by a synovial membrane, and separates translational and rotational motion" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent articular disc of temporomandibular joint" EXACT []
synonym: "absent articular disk of temporomandibular joint" EXACT []
synonym: "absent temporomandibular articular disc" EXACT []
synonym: "absent temporomandibular articular disk" EXACT []
synonym: "absent temporomandibular joint disc" EXACT []
synonym: "absent temporomandibular joint meniscus" EXACT []
synonym: "absent TMJ disc" EXACT []
synonym: "absent TMJ disk" EXACT []
is_a: MP:0030330 ! abnormal temporomandibular joint disk morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T11:56:06Z" xsd:dateTime

[Term]
id: MP:0030332
name: accelerated temporomandibular joint osteoarthritis
def: "earlier onset or more rapid progression of a degenerative condition of the temporomandibular joint that results from breakdown of joint cartilage and underlying bone; erosive lesions and joint space narrowing usually indicate acute or early changes, whereas sclerosis, flattening, subchondral cysts, and osteophytes may indicate late changes" [http://www.sciencedirect.com/science/article/pii/S2319417016301536, https://orcid.org/0000-0002-6490-7723]
synonym: "accelerated TMJ osteoarthritis" EXACT []
synonym: "early onset of temporomandibular joint osteoarthritis" EXACT []
synonym: "precocious temporomandibular joint osteoarthritis" EXACT []
synonym: "premature temporomandibular joint osteoarthritis" EXACT []
is_a: MP:0003560 ! osteoarthritis
is_a: MP:0011210 ! abnormal temporomandibular joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-27T12:12:21Z" xsd:dateTime

[Term]
id: MP:0030333
name: abnormal palatine bone perpendicular plate morphology
def: "any structural anomaly of the part of the palatine bone that extends vertically upward from the horizontal lamina; it forms part of the lateral wall of the nasal cavity" [https://medical-dictionary.thefreedictionary.com/perpendicular+plate+of+palatine+bone]
synonym: "abnormal lamina perpendicularis ossis palatini morphology" EXACT []
synonym: "abnormal palatine bone vertical plate morphology" EXACT []
is_a: MP:0005249 ! abnormal palatine bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:14:49Z" xsd:dateTime

[Term]
id: MP:0030334
name: absent sixth pharyngeal arch artery
def: "failure to develop or absence of the sixth pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent sixth aortic arch artery" EXACT []
synonym: "absent sixth branchial arch artery" EXACT []
synonym: "absent sixth PAA" EXACT []
synonym: "sixth pharyngeal arch artery agenesis" EXACT []
synonym: "sixth pharyngeal arch artery aplasia" EXACT []
is_a: MP:0006355 ! abnormal sixth pharyngeal arch artery morphology
is_a: MP:0012493 ! absent pharyngeal arch arteries
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:24:16Z" xsd:dateTime

[Term]
id: MP:0030335
name: absent third pharyngeal arch artery
def: "failure to develop or absence of the third pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent third aortic arch artery" EXACT []
synonym: "absent third branchial arch artery" EXACT []
synonym: "absent third PAA" EXACT []
synonym: "third pharyngeal arch artery agenesis" EXACT []
synonym: "third pharyngeal arch artery aplasia" EXACT []
is_a: MP:0006356 ! abnormal third pharyngeal arch artery morphology
is_a: MP:0012493 ! absent pharyngeal arch arteries
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:36:18Z" xsd:dateTime

[Term]
id: MP:0030336
name: third pharyngeal arch artery hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the third pharyngeal arch artery, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic third aortic arch artery" EXACT []
synonym: "hypoplastic third branchial arch artery" EXACT []
synonym: "hypoplastic third PAA" EXACT []
synonym: "hypoplastic third pharyngeal arch artery" EXACT []
is_a: MP:0006356 ! abnormal third pharyngeal arch artery morphology
is_a: MP:0012492 ! pharyngeal arch artery hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:40:54Z" xsd:dateTime

[Term]
id: MP:0030337
name: enlarged third pharyngeal arch artery
def: "increased size of the third pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormally large third pharyngeal arch artery" EXACT []
synonym: "enlarged third aortic arch artery" EXACT []
synonym: "enlarged third branchial arch artery" EXACT []
synonym: "enlarged third PAA" EXACT []
is_a: MP:0006356 ! abnormal third pharyngeal arch artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:45:31Z" xsd:dateTime

[Term]
id: MP:0030338
name: dilated third pharyngeal arch artery
def: "stretched or widened aperture of the luminal space of the third pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "3rd PAA dilation" EXACT []
synonym: "3rd pharyngeal arch artery dilation" EXACT []
synonym: "dilated third aortic arch artery" EXACT []
synonym: "dilated third branchial arch artery" EXACT []
synonym: "dilated third PAA" EXACT []
synonym: "dilation of the 3rd pharyngeal arch artery" EXACT []
synonym: "third aortic arch artery dilation" EXACT []
synonym: "third branchial arch artery dilation" EXACT []
synonym: "third PAA dilation" EXACT []
synonym: "third pharyngeal arch artery dilation" EXACT []
is_a: MP:0006356 ! abnormal third pharyngeal arch artery morphology
is_a: MP:0012494 ! dilated pharyngeal arch artery
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T12:49:47Z" xsd:dateTime

[Term]
id: MP:0030339
name: absent second pharyngeal arch artery
def: "failure to develop or absence of the second pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent second aortic arch artery" EXACT []
synonym: "absent second branchial arch artery" EXACT []
synonym: "absent second PAA" EXACT []
synonym: "second pharyngeal arch artery agenesis" EXACT []
synonym: "second pharyngeal arch artery aplasia" EXACT []
is_a: MP:0010356 ! abnormal second pharyngeal arch artery morphology
is_a: MP:0012493 ! absent pharyngeal arch arteries
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T13:03:11Z" xsd:dateTime

[Term]
id: MP:0030340
name: absent fourth pharyngeal arch artery
def: "failure to develop or absence of the fourth pharyngeal arch artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent fourth aortic arch artery" EXACT []
synonym: "absent fourth branchial arch artery" EXACT []
synonym: "absent fourth PAA" EXACT []
synonym: "fourth pharyngeal arch artery agenesis" EXACT []
synonym: "fourth pharyngeal arch artery aplasia" EXACT []
is_a: MP:0006354 ! abnormal fourth pharyngeal arch artery morphology
is_a: MP:0012493 ! absent pharyngeal arch arteries
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T13:29:50Z" xsd:dateTime

[Term]
id: MP:0030341
name: fourth pharyngeal arch artery hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the fourth pharyngeal arch artery, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic fourth aortic arch artery" EXACT []
synonym: "hypoplastic fourth branchial arch artery" EXACT []
synonym: "hypoplastic fourth PAA" EXACT []
synonym: "hypoplastic fourth pharyngeal arch artery" EXACT []
is_a: MP:0006354 ! abnormal fourth pharyngeal arch artery morphology
is_a: MP:0012492 ! pharyngeal arch artery hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-10-30T13:33:57Z" xsd:dateTime

[Term]
id: MP:0030342
name: small maxillary prominence
def: "reduced size of the paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased maxillary prominence size" EXACT []
synonym: "reduced maxillary prominence size" EXACT []
synonym: "small embryonic maxillary process" EXACT []
synonym: "small maxillary process" EXACT []
is_a: MP:0010940 ! abnormal maxillary prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T07:40:00Z" xsd:dateTime

[Term]
id: MP:0030343
name: maxillary prominence hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the maxillary prominence, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic embryonic maxillary process" EXACT []
synonym: "hypoplastic maxillary process" EXACT []
synonym: "hypoplastic maxillary prominence" EXACT []
is_a: MP:0030342 ! small maxillary prominence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T07:45:45Z" xsd:dateTime

[Term]
id: MP:0030344
name: absent maxillary prominence
def: "absence of the paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent embryonic maxillary process" EXACT []
synonym: "absent maxillary process" EXACT []
is_a: MP:0010940 ! abnormal maxillary prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T07:49:36Z" xsd:dateTime

[Term]
id: MP:0030345
name: enlarged maxillary prominence
def: "increased size of the paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged embryonic maxillary process" EXACT []
synonym: "enlarged maxillary process" EXACT []
synonym: "increased maxillary prominence size" EXACT []
is_a: MP:0010940 ! abnormal maxillary prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T07:52:52Z" xsd:dateTime

[Term]
id: MP:0030346
name: small mandibular prominence
def: "reduced size of the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mandibular prominence size" EXACT []
synonym: "reduced mandibular prominence size" EXACT []
synonym: "small mandibular process" EXACT []
is_a: MP:0010939 ! abnormal mandibular prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T07:59:27Z" xsd:dateTime

[Term]
id: MP:0030347
name: mandibular prominence hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mandibular prominence, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic mandibular process" EXACT []
synonym: "hypoplastic mandibular prominence" EXACT []
synonym: "mandibular process hypoplasia" EXACT []
is_a: MP:0030346 ! small mandibular prominence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T08:03:04Z" xsd:dateTime

[Term]
id: MP:0030348
name: enlarged mandibular prominence
def: "increased size of the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged mandibular process" EXACT []
synonym: "increased mandibular process size" EXACT []
synonym: "increased mandibular prominence size" EXACT []
is_a: MP:0010939 ! abnormal mandibular prominence morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T08:07:21Z" xsd:dateTime

[Term]
id: MP:0030349
name: absent coronal suture
def: "failure to form the dense, fibrous connective tissue joint between the parietal bones and the frontal bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent frontoparietal suture" EXACT []
is_a: MP:0003840 ! abnormal coronal suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T09:48:27Z" xsd:dateTime

[Term]
id: MP:0030350
name: premature coronal suture closure
def: "early closure of the coronal suture of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "coronal craniosynostosis" EXACT []
synonym: "coronal suture craniosynostosis" EXACT []
synonym: "coronal suture synostosis" EXACT []
synonym: "early fusion of coronal sutures" EXACT []
synonym: "frontoparietal craniosynostosis" EXACT []
synonym: "frontoparietal suture craniosynostosis" EXACT []
synonym: "frontoparietal suture synostosis" EXACT []
is_a: MP:0000081 ! premature cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T11:25:26Z" xsd:dateTime

[Term]
id: MP:0030351
name: wide coronal suture
def: "an abnormally increased width of the coronal suture for age-related norms" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad coronal suture" EXACT []
synonym: "broadened coronal suture" EXACT []
synonym: "large coronal suture" EXACT []
synonym: "wide frontoparietal suture" EXACT []
synonym: "wide spaced coronal suture" EXACT []
synonym: "widened coronal suture" EXACT []
is_a: MP:0003840 ! abnormal coronal suture morphology
is_a: MP:0030029 ! wide cranial sutures
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T11:44:04Z" xsd:dateTime

[Term]
id: MP:0030352
name: absent sagittal suture
def: "failure to form the dense, fibrous connective tissue joint between the two parietal bones of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent interparietal suture" EXACT []
synonym: "absent longitudinal suture" EXACT []
synonym: "absent parietal suture" EXACT []
is_a: MP:0003843 ! abnormal sagittal suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T12:02:51Z" xsd:dateTime

[Term]
id: MP:0030353
name: wide sagittal suture
def: "an abnormally increased width of the sagittal suture for age-related norms" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad sagittal l suture" EXACT []
synonym: "large sagittal suture" EXACT []
synonym: "wide interparietal suture" EXACT []
synonym: "wide longitudinal suture" EXACT []
synonym: "wide parietal suture" EXACT []
synonym: "wide spaced sagittal suture" EXACT []
synonym: "widened sagittal suture" EXACT []
is_a: MP:0003843 ! abnormal sagittal suture morphology
is_a: MP:0030029 ! wide cranial sutures
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T12:07:59Z" xsd:dateTime

[Term]
id: MP:0030354
name: premature sagittal suture closure
def: "early closure of the sagittal suture of the skull; premature closure of this suture results in a long, narrow, and boat-shaped skull (scaphocephaly)" [https://radiopaedia.org/articles/craniosynostosis]
synonym: "early fusion of sagittal sutures" EXACT []
synonym: "interparietal suture synostosis" EXACT []
synonym: "longitudinal suture synostosis" EXACT []
synonym: "parietal suture synostosis" EXACT []
synonym: "sagittal craniosynostosis" EXACT []
synonym: "sagittal suture craniosynostosis" EXACT []
synonym: "sagittal suture synostosis" EXACT []
synonym: "sagittal synostosis" EXACT []
is_a: MP:0000081 ! premature cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T12:20:00Z" xsd:dateTime

[Term]
id: MP:0030355
name: absent lambdoid suture
def: "failure to form the dense, fibrous connective tissue joint between the superior border of the occipital bone and the posterior borders of the right and left parietal bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lambdoidal suture" EXACT []
synonym: "absent occipital suture" EXACT []
synonym: "absent occipitoparietal suture" EXACT []
is_a: MP:0003841 ! abnormal lambdoid suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T13:04:52Z" xsd:dateTime

[Term]
id: MP:0030356
name: premature lambdoid suture closure
def: "early closure of the lambdoid suture of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of lambdoid sutures" EXACT []
synonym: "lambdoid craniosynostosis" EXACT []
synonym: "lambdoid suture craniosynostosis" EXACT []
synonym: "lambdoid suture synostosis" EXACT []
synonym: "lambdoid synostosis" EXACT []
synonym: "lambdoidal craniosynostosis" EXACT []
synonym: "lambdoidal suture craniosynostosis" EXACT []
synonym: "lambdoidal suture synostosis" EXACT []
synonym: "lambdoidal synostosis" EXACT []
is_a: MP:0000081 ! premature cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T13:12:08Z" xsd:dateTime

[Term]
id: MP:0030357
name: wide lambdoid suture
def: "an abnormally increased width of the lambdoid suture for age-related norms" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad lambdoid suture" EXACT []
synonym: "broadened lambdoid suture" EXACT []
synonym: "large lambdoid suture" EXACT []
synonym: "wide lambdoidal suture" EXACT []
synonym: "wide spaced lambdoid suture" EXACT []
synonym: "widened lambdoid suture" EXACT []
is_a: MP:0003841 ! abnormal lambdoid suture morphology
is_a: MP:0030029 ! wide cranial sutures
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T13:19:38Z" xsd:dateTime

[Term]
id: MP:0030358
name: premature squamoparietal suture closure
def: "early closure of the squamoparietal suture of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of squamoparietal sutures" EXACT []
synonym: "early fusion of squamosal sutures" EXACT []
synonym: "early fusion of squamous sutures" EXACT []
synonym: "squamoparietal craniosynostosis" EXACT []
synonym: "squamoparietal suture craniosynostosis" EXACT []
synonym: "squamoparietal suture synostosis" EXACT []
synonym: "squamoparietal synostosis" EXACT []
synonym: "squamosal craniosynostosis" EXACT []
synonym: "squamosal suture craniosynostosis" EXACT []
synonym: "squamosal suture synostosis" EXACT []
synonym: "squamosal synostosis" EXACT []
is_a: MP:0000081 ! premature cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-01T13:42:26Z" xsd:dateTime

[Term]
id: MP:0030359
name: cranial suture sclerosis
def: "an increased density in one or more cranial sutures following obliteration" [HP:0005441, https://books.google.com/books?isbn=1447134923]
synonym: "perisutural sclerosis" RELATED []
synonym: "sclerotic cranial sutures" EXACT []
is_a: MP:0002835 ! abnormal cranial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T10:56:20Z" xsd:dateTime

[Term]
id: MP:0030360
name: coronal suture sclerosis
def: "an increased density in the coronal suture following obliteration" [https://orcid.org/0000-0002-6490-7723]
synonym: "sclerotic coronal sutures" EXACT []
synonym: "sclerotic frontoparietal sutures" EXACT []
is_a: MP:0003840 ! abnormal coronal suture morphology
is_a: MP:0030359 ! cranial suture sclerosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T11:09:37Z" xsd:dateTime

[Term]
id: MP:0030361
name: lambdoid suture sclerosis
def: "an increased density in the lambdoid suture following obliteration" [https://orcid.org/0000-0002-6490-7723]
synonym: "lambdoidal suture sclerosis" EXACT []
synonym: "sclerotic lambdoid sutures" EXACT []
synonym: "sclerotic lambdoidal sutures" EXACT []
is_a: MP:0003841 ! abnormal lambdoid suture morphology
is_a: MP:0030359 ! cranial suture sclerosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T11:15:47Z" xsd:dateTime

[Term]
id: MP:0030362
name: sagittal suture sclerosis
def: "an increased density in the sagittal suture following obliteration" [https://orcid.org/0000-0002-6490-7723]
synonym: "sclerotic interparietal sutures" EXACT []
synonym: "sclerotic longitudinal sutures" EXACT []
synonym: "sclerotic parietal sutures" EXACT []
synonym: "sclerotic sagittal sutures" EXACT []
is_a: MP:0003843 ! abnormal sagittal suture morphology
is_a: MP:0030359 ! cranial suture sclerosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T11:22:03Z" xsd:dateTime

[Term]
id: MP:0030363
name: abnormal anterior fontanelle morphology
def: "any structural anomaly of the diamond-shaped membranous interval between the two frontal and two parietal bones of the developing fetal skull; it is the largest fontanelle, located at the bregma, at the junction of the coronal, sagittal and metopic (frontal) sutures of the cranium" [https://en.wikipedia.org/wiki/Fontanelle]
synonym: "abnormal anterior fontanel morphology" EXACT []
synonym: "abnormal bregmatic fontanel morphology" EXACT []
synonym: "abnormal bregmatic fontanelle morphology" EXACT []
synonym: "abnormal frontal fontanel morphology" EXACT []
synonym: "abnormal frontal fontanelle morphology" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T11:31:04Z" xsd:dateTime

[Term]
id: MP:0030364
name: abnormal posterior fontanelle morphology
def: "any structural anomaly of the triangle-shaped membranous interval between the pair of parietal bones and the occipital bone; it is located at the lambda, at the junction between the sagittal suture and the lambdoid suture" [https://en.wikipedia.org/wiki/Posterior_fontanelle]
synonym: "abnormal lambdoid fontanel morphology" EXACT []
synonym: "abnormal lambdoid fontanelle morphology" EXACT []
synonym: "abnormal occipital fontanel morphology" EXACT []
synonym: "abnormal occipital fontanelle morphology" EXACT []
synonym: "abnormal posterior fontanel morphology" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T11:52:06Z" xsd:dateTime

[Term]
id: MP:0030365
name: abnormal sphenoid fontanelle morphology
def: "any structural anomaly of the small membranous interval located on the side of the skull, at the site of apposition of the frontal, parietal, and squamous part of the temporal bone and sphenoid bone" [http://www.anatomyexpert.com/app/structure/1622/1122/, https://books.google.com/books?isbn=0124020607]
synonym: "abnormal anterolateral fontanel morphology" EXACT []
synonym: "abnormal anterolateral fontanelle morphology" EXACT []
synonym: "abnormal sphenoid fontanel morphology" EXACT []
synonym: "abnormal sphenoidal fontanel morphology" EXACT []
synonym: "abnormal sphenoidal fontanelle morphology" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T12:13:02Z" xsd:dateTime

[Term]
id: MP:0030366
name: abnormal mastoid fontanelle morphology
def: "any structural anomaly of the small membranous interval between the posterolateral angle of the parietal bone and the mastoid regions of the temporal and occipital bones in the developing skull" [http://www.anatomyexpert.com/app/structure/1632/1122/]
synonym: "abnormal mastoid fontanel morphology" EXACT []
synonym: "abnormal posterolateral fontanel morphology" EXACT []
synonym: "abnormal posterolateral fontanelle morphology" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-06T12:30:55Z" xsd:dateTime

[Term]
id: MP:0030367
name: premature metopic suture closure
def: "early closure of the metopic suture of the skull; premature closure of this suture compromises the transverse growth of both the frontal bones and can cause a narrow, triangular shaped forehead (trigonocephaly) that is associated with orbital hypotelorism" [http://www.skullbaseinstitute.com/craniosynostosis-craniofacial/trigonocephaly.html, PMID:23960302]
comment: In mice and rats, the posterior frontal suture (analogous to the human metopic suture) is the only cranial suture that fuses naturally during the first month of life; fusion proceeds in a defined temporal sequence from an anterior to posterior direction, while all other cranial sutures remain patent throughout the life of the animal {xref="PMID:23300083", xref="PMID:15790973", xref="PMID:8911474"}
synonym: "early fusion of frontal sutures" EXACT []
synonym: "early fusion of interfrontal sutures" EXACT []
synonym: "early fusion of median frontal sutures" EXACT []
synonym: "early fusion of metopic sutures" EXACT []
synonym: "metopic craniosynostosis" EXACT []
synonym: "metopic suture craniosynostosis" EXACT []
synonym: "metopic suture synostosis" EXACT []
synonym: "metopic synostosis" EXACT []
synonym: "premature frontal suture closure" EXACT []
synonym: "premature interfrontal suture closure" EXACT []
synonym: "premature mediofrontal suture closure" EXACT []
is_a: MP:0000081 ! premature cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T10:55:47Z" xsd:dateTime

[Term]
id: MP:0030368
name: trigonocephaly
def: "presence of a wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput; trigonocephaly can be caused by premature fusion of the metopic suture" [HP:0000243, http://www.skullbaseinstitute.com/craniosynostosis-craniofacial/trigonocephaly.html]
synonym: "triangular cranium shape" EXACT []
synonym: "triangular head shape" BROAD []
synonym: "triangular shaped forehead" RELATED []
synonym: "triangular skull shape" EXACT []
synonym: "wedge shaped cranium" EXACT []
synonym: "wedge shaped head" BROAD []
synonym: "wedge shaped skull" EXACT []
is_a: MP:0011495 ! abnormal head shape
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T11:36:27Z" xsd:dateTime

[Term]
id: MP:0030369
name: abnormal jugum limitans morphology
def: "any structural anomaly of the bony ridge that, in rodents, runs paracoronally and divides the metopic (interfrontal) suture transversely into the anterior and posterior frontal sutures; it is a landmark between the posterior and anterior frontal sutures" [http://onlinelibrary.wiley.com/doi/10.1359/jbmr.1997.12.3.311/full, https://helda.helsinki.fi/bitstream/handle/10138/20292/molecula.pdf?sequence=1, PMID:15882577]
synonym: "abnormal jugum limitans olfacoriae morphology" EXACT []
is_a: MP:0003842 ! abnormal metopic suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T12:39:03Z" xsd:dateTime

[Term]
id: MP:0030370
name: absent jugum limitans
def: "missing the bony ridge that, in rodents, runs paracoronally and divides the metopic (interfrontal) suture transversely into the anterior and posterior frontal sutures" [https://orcid.org/0000-0002-6490-7723, PMID:15790973]
synonym: "absent jugum limitans olfacoriae" EXACT []
is_a: MP:0030369 ! abnormal jugum limitans morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T12:44:21Z" xsd:dateTime

[Term]
id: MP:0030371
name: delayed sagittal suture closure
def: "late onset of fusion of the sagittal suture of the skull" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed fusion of sagittal sutures" EXACT []
synonym: "late-closing sagittal sutures" EXACT []
is_a: MP:0010743 ! delayed cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T13:08:39Z" xsd:dateTime

[Term]
id: MP:0030372
name: enlarged Meckel's cartilage
def: "increased size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged mandibular cartilage" EXACT []
synonym: "enlarged Meckel cartilage" EXACT []
synonym: "increased mandibular cartilage size" EXACT []
synonym: "increased Meckel cartilage size" EXACT []
synonym: "increased Meckel's cartilage size" EXACT []
is_a: MP:0005587 ! abnormal Meckel's cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T13:33:01Z" xsd:dateTime

[Term]
id: MP:0030373
name: Meckel's cartilage hyperplasia
def: "increase in the number of normal cells in normal arrangement in the Meckel's cartilage, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic mandibular cartilage" EXACT []
synonym: "hyperplastic Meckel cartilage" EXACT []
synonym: "hyperplastic Meckel's cartilage" EXACT []
synonym: "mandibular cartilage hyperplasia" EXACT []
synonym: "Meckel cartilage hyperplasia" EXACT []
is_a: MP:0030372 ! enlarged Meckel's cartilage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T13:55:38Z" xsd:dateTime

[Term]
id: MP:0030374
name: Meckel's cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the Meckel's cartilage, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic mandibular cartilage" EXACT []
synonym: "hypoplastic Meckel cartilage" EXACT []
synonym: "hypoplastic Meckel's cartilage" EXACT []
synonym: "mandibular cartilage hypoplasia" EXACT []
synonym: "Meckel cartilage hypoplasia" EXACT []
is_a: MP:0030026 ! small Meckel's cartilage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-08T14:12:32Z" xsd:dateTime

[Term]
id: MP:0030375
name: short zygomatic arch
def: "decreased length of the bony arch that, in vertebrates, extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased zygomatic arch length" EXACT []
synonym: "reduced zygomatic arch length" EXACT []
synonym: "short malar arch" EXACT []
synonym: "short zygoma" EXACT []
synonym: "shortened zygomatic arch" EXACT []
is_a: MP:0004469 ! abnormal zygomatic arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T11:35:27Z" xsd:dateTime

[Term]
id: MP:0030376
name: thick zygomatic arch
def: "increased thickness of the bony arch that, in vertebrates, extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased zygomatic arch thickness" EXACT []
synonym: "thick malar arch" EXACT []
synonym: "thick zygoma" EXACT []
synonym: "thickened zygomatic arch" EXACT []
is_a: MP:0004469 ! abnormal zygomatic arch morphology
is_a: MP:0030278 ! thick neurocranium
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T11:44:09Z" xsd:dateTime

[Term]
id: MP:0030377
name: zygomatic arch hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the zygomatic arch, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic malar arch" EXACT []
synonym: "hypoplastic zygoma" EXACT []
synonym: "hypoplastic zygomatic arch" EXACT []
is_a: MP:0004469 ! abnormal zygomatic arch morphology
is_a: MP:0030386 ! facial bone hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T11:48:32Z" xsd:dateTime

[Term]
id: MP:0030378
name: abnormal frontal bone nasal part morphology
def: "any structural anomaly of the smallest part of the frontal bone which is connected to the frontal processes of the maxilla and the nasal bones, forming the stem (root) of the nose" [http://www.wow.com/wiki/Frontal_bone?s_pt=aolsem&s_chn=3, https://www.kenhub.com/en/library/anatomy/the-frontal-bone]
synonym: "abnormal pars nasalis ossis frontalis morphology" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T11:58:18Z" xsd:dateTime

[Term]
id: MP:0030379
name: abnormal frontal bone squamous part morphology
def: "any structural anomaly of the vertical and largest, flat part of the frontal bone which forms the forehead and comprises the frontal sinuses; this part contains the supraorbital notch, the superciliary arches, the glabella, and the zygomatic processes which arise caudolaterally from the squamous part and articulate with the zygomatic bone" [https://www.getbodysmart.com/ap/skeletalsystem/skeleton/axial/skull/cranialbones/frontal/tutorial.html, https://www.kenhub.com/en/library/anatomy/the-frontal-bone]
synonym: "abnormal frontal bone vertical part morphology" BROAD []
synonym: "abnormal squama frontalis morphology" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T12:10:12Z" xsd:dateTime

[Term]
id: MP:0030380
name: abnormal frontal bone zygomatic process morphology
def: "any structural anomaly of the inferior extension of the squamous part of the frontal bone that joins with the frontal process of the zygomatic bone" [https://www.getbodysmart.com/ap/skeletalsystem/skeleton/axial/skull/cranialbones/frontal/tutorial.html]
synonym: "abnormal processus zygomaticus (os frontale) morphology" EXACT []
synonym: "abnormal processus zygomaticus frontalis morphology" EXACT []
synonym: "abnormal processus zygomaticus ossis frontalis morphology" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T12:20:11Z" xsd:dateTime

[Term]
id: MP:0030381
name: abnormal frontal bone orbital part morphology
def: "any structural anomaly of the horizontal part of the frontal bone composed of two thin triangular plates, the orbital plates, which form the vaults of the orbits and the ethmoidal sinuses, and are separated from one another by a median gap, the ethmoidal notch; this part also comprises the anterior and posterior ethmoidal foramina" [https://radiopaedia.org/articles/frontal-bone, https://www.kenhub.com/en/library/anatomy/the-frontal-bone, UBERON:0011627]
synonym: "abnormal frontal bone horizontal part morphology" BROAD []
synonym: "abnormal pars orbitalis (os frontale) morphology" EXACT []
synonym: "abnormal pars orbitalis ossis frontalis morphology" EXACT []
is_a: MP:0000107 ! abnormal frontal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T13:22:34Z" xsd:dateTime

[Term]
id: MP:0030382
name: absent paranasal sinus
def: "missing one or more of the paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent paranasal sinuses" EXACT []
synonym: "missing sinuses" BROAD []
synonym: "obliterated paranasal sinuses" EXACT []
is_a: MP:0002240 ! abnormal paranasal sinus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T13:43:15Z" xsd:dateTime

[Term]
id: MP:0030383
name: small presphenoid bone
def: "reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased presphenoid bone size" EXACT []
synonym: "reduced presphenoid bone size" EXACT []
is_a: MP:0004448 ! abnormal presphenoid bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T14:13:30Z" xsd:dateTime

[Term]
id: MP:0030384
name: short facial bone
def: "length reduction or truncation of one or more facial bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased facial bone length" EXACT []
synonym: "reduced facial bone length" EXACT []
synonym: "short facial bones" EXACT []
synonym: "shortened facial bones" EXACT []
synonym: "truncated facial bones" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T15:16:40Z" xsd:dateTime

[Term]
id: MP:0030385
name: absent facial bone
def: "failure to develop or absence of one or more facial bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent facial bones" EXACT []
synonym: "facial bone agenesis" EXACT []
synonym: "facial bone aplasia" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T15:45:24Z" xsd:dateTime

[Term]
id: MP:0030386
name: facial bone hypoplasia
def: "decrease in the number of normal cells in normal arrangement in a facial bone, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic facial bone" EXACT []
synonym: "hypoplastic facial bones" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-10T17:08:08Z" xsd:dateTime

[Term]
id: MP:0030387
name: large posterior fontanelle
def: "an abnormally increased size of the triangle-shaped membranous interval between the pair of parietal bones and the occipital bone for age-related norms; the posterior fontanelle is located at the lambda, at the junction between the sagittal suture and the lambdoid suture" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged lambdoid fontanelle" EXACT []
synonym: "enlarged occipital fontanelle" EXACT []
synonym: "enlarged posterior fontanelle" EXACT []
synonym: "large lambdoid fontanel" EXACT []
synonym: "large lambdoid fontanelle" EXACT []
synonym: "large occipital fontanel" EXACT []
synonym: "large occipital fontanelle" EXACT []
synonym: "large open posterior fontanelle" EXACT []
synonym: "large posterior fontanel" EXACT []
synonym: "wide open posterior fontanelle" EXACT []
synonym: "wide posterior fontanelle" EXACT []
is_a: MP:0030364 ! abnormal posterior fontanelle morphology
is_a: MP:0030388 ! large fontanelles
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-13T09:54:33Z" xsd:dateTime

[Term]
id: MP:0030388
name: large fontanelles
def: "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged fontanelle" EXACT []
synonym: "enlarged fontanelles" EXACT []
synonym: "enlarged fontanels" EXACT []
synonym: "large fontanel" EXACT []
synonym: "large fontanelle" EXACT []
synonym: "large fontanels" EXACT []
synonym: "large open fontanelles" EXACT []
synonym: "persistent wide fontanel" EXACT []
synonym: "wide fontanelles" EXACT []
synonym: "wide open fontanelles" EXACT []
synonym: "widened fontanelles" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-13T11:10:14Z" xsd:dateTime

[Term]
id: MP:0030389
name: small fontanelles
def: "an abnormally decreased size of one or more fontanelles for age-related norms" [HP:0005486, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased fontanelle size" EXACT []
synonym: "reduced fontanelle size" EXACT []
synonym: "small fontanel" EXACT []
synonym: "small fontanelle" EXACT []
synonym: "small fontanels" EXACT []
is_a: MP:0000084 ! abnormal fontanelle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-13T11:29:53Z" xsd:dateTime

[Term]
id: MP:0030390
name: premature facial suture closure
def: "early closure of one or more of the joints (sutures) between facial bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of facial sutures" EXACT []
synonym: "facial suture synostosis" EXACT []
is_a: MP:0030435 ! premature craniofacial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-13T12:44:30Z" xsd:dateTime

[Term]
id: MP:0030391
name: premature zygomaticomaxillary suture closure
def: "early closure of the suture between the zygomatic process of the maxilla and the maxillary margin of the zygomatic bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of zygomaticomaxillary sutures" EXACT []
is_a: MP:0030390 ! premature facial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-13T13:31:15Z" xsd:dateTime

[Term]
id: MP:0030392
name: premature fontanelle closure
def: "early closure of one or more of the membranous intervals at the margins of cranial bones; premature fontanelle closure can result from microcephaly, premature closure of the cranial sutures, or hyperthyroidism" [HP:0005458, https://books.google.com/books?isbn=0826123678, https://orcid.org/0000-0002-6490-7723]
synonym: "early closure of the soft spots" EXACT []
synonym: "early fontanelle closure" EXACT []
synonym: "obliterated fontanelles" EXACT []
synonym: "obliterated fontanels" EXACT []
synonym: "premature fontanel closure" EXACT []
is_a: MP:0003418 ! premature intramembranous bone ossification
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T09:10:00Z" xsd:dateTime

[Term]
id: MP:0030393
name: delayed fontanelle closure
def: "late onset of closure of one or more of the membranous intervals at the margins of cranial bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed fontanel closure" EXACT []
synonym: "late closure of the soft spots" EXACT []
is_a: MP:0010743 ! delayed cranial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T09:40:06Z" xsd:dateTime

[Term]
id: MP:0030394
name: abnormal incus short process morphology
def: "any structural anomaly of the short limb (crus) of the incus that fits into a depression (fossa incudis) in the epitympanic recess; it is attached to the cavity wall by the posterior incudal ligament" [http://audilab.bmed.mcgill.ca/~daren/3Dear/mid1.html, https://medical-dictionary.thefreedictionary.com/short+limb+of+incus]
synonym: "abnormal crus breve incudis morphology" EXACT []
synonym: "abnormal incus short crus morphology" EXACT []
synonym: "abnormal incus short limb morphology" EXACT []
is_a: MP:0005106 ! abnormal incus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:21:57Z" xsd:dateTime

[Term]
id: MP:0030395
name: absent incus short process
def: "missing the short limb (crus) of the incus that, normally, fits into a depression (fossa incudis) in the epitympanic recess" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent crus breve incudis" EXACT []
synonym: "absent incus short crus" EXACT []
synonym: "absent incus short limb" EXACT []
is_a: MP:0030394 ! abnormal incus short process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:32:32Z" xsd:dateTime

[Term]
id: MP:0030396
name: abnormal incus long process morphology
def: "any structural anomaly of the long limb (crus) of the incus; at the tip of the long crus there is a small knob, the lenticular process, that articulates with the head of the stapes" [https://medical-dictionary.thefreedictionary.com/long+limb+of+incus]
synonym: "abnormal crus longum incudis morphology" EXACT []
synonym: "abnormal incus long crus morphology" EXACT []
synonym: "abnormal incus long limb morphology" EXACT []
is_a: MP:0005106 ! abnormal incus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:35:35Z" xsd:dateTime

[Term]
id: MP:0030397
name: abnormal incus lenticular process morphology
def: "any structural anomaly of the ovoid end of the incus that articulates with the head of the stapes; it is attached to the long process by a thin strut or pedicle" [https://medical-dictionary.thefreedictionary.com/long+limb+of+incus, PMID:21986927]
synonym: "abnormal processus lenticularis incudis morphology" EXACT []
is_a: MP:0005106 ! abnormal incus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:39:16Z" xsd:dateTime

[Term]
id: MP:0030398
name: absent incus lenticular process
def: "missing the ovoid end of the incus that articulates with the head of the stapes; normally, it is attached to the long process by a thin strut or pedicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent processus lenticularis incudis" EXACT []
is_a: MP:0030397 ! abnormal incus lenticular process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:43:30Z" xsd:dateTime

[Term]
id: MP:0030399
name: abnormal incus body morphology
def: "any structural anomaly of the flat, main part of the incus that articulates with the head of the malleus; two spines, the short and long processes, arise from the lower posterior part of the body and diverge from each other in a right angle" [https://books.google.com/books?isbn=3642369677]
synonym: "abnormal corpus incudis morphology" EXACT []
is_a: MP:0005106 ! abnormal incus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-14T13:47:06Z" xsd:dateTime

[Term]
id: MP:0030400
name: abnormal stapes annular ligament morphology
def: "any structural anomaly of the ring of fibrous tissue that connects the base of the stapes to the oval window (aka fenestra vestibuli) of the inner ear" [https://en.wikipedia.org/wiki/Annular_ligament_of_stapes, UBERON:0018161]
synonym: "abnormal annular stapedial ligament morphology" EXACT []
synonym: "abnormal ligamentum annulare stapedis morphology" EXACT []
synonym: "abnormal stapedial annular ligament morphology" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology
is_a: MP:0005504 ! abnormal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:17:38Z" xsd:dateTime

[Term]
id: MP:0030401
name: absent stapes annular ligament
def: "missing the ring of fibrous tissue that connects the base of the stapes to the oval window (aka fenestra vestibuli) of the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent annular stapedial ligament" EXACT []
synonym: "absent ligamentum annulare stapedis" EXACT []
synonym: "absent stapedial annular ligament" EXACT []
is_a: MP:0030400 ! abnormal stapes annular ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:26:08Z" xsd:dateTime

[Term]
id: MP:0030402
name: abnormal stapes head morphology
def: "any structural anomaly of the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [http://www.biology-online.org/dictionary/Head_of_stapes, https://radiopaedia.org/articles/stapes]
synonym: "abnormal caput stapedis morphology" EXACT []
synonym: "abnormal stapedial head morphology" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:32:04Z" xsd:dateTime

[Term]
id: MP:0030403
name: absent stapes head
def: "missing the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent caput stapedis" EXACT []
synonym: "absent stapedial head" EXACT []
is_a: MP:0030402 ! abnormal stapes head morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:36:49Z" xsd:dateTime

[Term]
id: MP:0030404
name: abnormal stapes obturator foramen morphology
def: "any structural anomaly of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [PMID:10696017, PMID:22176756]
synonym: "abnormal intercrural foramen of stapes morphology" EXACT []
synonym: "abnormal obturator foramen of stapes morphology" EXACT []
synonym: "abnormal stapedial foramen morphology" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:42:10Z" xsd:dateTime

[Term]
id: MP:0030405
name: small stapes obturator foramen
def: "reduced size of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased stapes obturator foramen size" EXACT []
synonym: "reduced stapes obturator foramen size" EXACT []
synonym: "small intercrural foramen of stapes" EXACT []
synonym: "small obturator foramen of stapes" EXACT []
synonym: "small stapedial foramen" EXACT []
is_a: MP:0030404 ! abnormal stapes obturator foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:47:37Z" xsd:dateTime

[Term]
id: MP:0030406
name: absent stapes obturator foramen
def: "missing the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent intercrural foramen of stapes" EXACT []
synonym: "absent obturator foramen of stapes" EXACT []
synonym: "absent stapedial foramen" EXACT []
is_a: MP:0030404 ! abnormal stapes obturator foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T14:50:53Z" xsd:dateTime

[Term]
id: MP:0030407
name: abnormal stapes crus morpholgy
def: "any structural anomaly of either of the two (anterior and posterior) limbs of the stapes that pass from the head to the base or footplate; in mice, the anterior crus is curved and the posterior crus is more straight whereas in humans, the anterior crus is more straight than the posterior crus" [https://medical-dictionary.thefreedictionary.com/anterior+crus+of+stapes, PMID:28117786]
synonym: "abnormal stapes crura morphology" EXACT []
synonym: "abnormal stapes limb morpholgy" EXACT []
is_a: MP:0005107 ! abnormal stapes morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T15:05:24Z" xsd:dateTime

[Term]
id: MP:0030408
name: abnormal stapes posterior crus morphology
def: "any structural anomaly of the generally longer arching stem of the stapes that projects medially from the neck, forming the posterior border of the bone, and joins the flat, disc-like base" [http://www.anatomyexpert.com/app/structure/746/1925/]
synonym: "abnormal crus posterius stapedis morphology" EXACT []
synonym: "abnormal stapes posterior limb morphology" EXACT []
is_a: MP:0030407 ! abnormal stapes crus morpholgy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T15:11:24Z" xsd:dateTime

[Term]
id: MP:0030409
name: abnormal stapes anterior crus morphology
def: "any structural anomaly of the generally shorter stem of the stapes that projects medially from the neck, forming the anterior border of the bone, and joins the flat, disc-like base" [http://www.anatomyexpert.com/app/structure/745/]
synonym: "abnormal crus anterius stapedis morphology" EXACT []
synonym: "abnormal stapes anterior limb morphology" EXACT []
is_a: MP:0030407 ! abnormal stapes crus morpholgy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-15T15:14:45Z" xsd:dateTime

[Term]
id: MP:0030410
name: middle ear effusion
def: "fluid accumulation in the middle ear cavity due to dysfunction of the Eustachian tube" [https://www.medscape.org/viewarticle/730698, PMID:1267372]
comment: fluid may be serous, mucoid, bloody, purulent or any combination thereof; the term does not distinguish between effusions due to acute otitis media (AOM) and effusions due to otitis media with effusion (OME) {comment="https://books.google.com/books?isbn=1550092545"}
synonym: "middle ear effusions" EXACT []
is_a: MP:0021205 ! effusion
is_a: MP:0030154 ! abnormal tympanic cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T11:30:38Z" xsd:dateTime

[Term]
id: MP:0030411
name: decreased round window size
def: "less than average size of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased cochlear window size" EXACT []
synonym: "decreased fenestra cochleae size" EXACT []
synonym: "decreased fenestra rotunda size" EXACT []
synonym: "reduced round window size" EXACT []
synonym: "small cochlear window" EXACT []
synonym: "small fenestra cochleae" EXACT []
synonym: "small fenestra of the cochlea" EXACT []
synonym: "small fenestra rotunda" EXACT []
synonym: "small round window" EXACT []
is_a: MP:0004480 ! abnormal round window morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:07:08Z" xsd:dateTime

[Term]
id: MP:0030412
name: absent round window
def: "absence of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent cochlear window" EXACT []
synonym: "absent fenestra cochleae" EXACT []
synonym: "absent fenestra of the cochlea" EXACT []
synonym: "absent fenestra rotunda" EXACT []
is_a: MP:0004480 ! abnormal round window morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:13:07Z" xsd:dateTime

[Term]
id: MP:0030413
name: tympanic membrane retraction
def: "a condition in which a segment of the tympanic membrane (eardrum) collapses inwards towards the middle ear space and lies more medially (deeper) than its normal position; the retracted segment is often known as a retraction pocket" [http://allearseducation.org/resources/Tutorial-10-Retractions.pdf, https://en.wikipedia.org/wiki/Tympanic_membrane_retraction]
synonym: "eardrum retraction" EXACT []
synonym: "retracted eardrum" EXACT []
synonym: "retracted tympanic membrane" EXACT []
is_a: MP:0006018 ! abnormal tympanic membrane morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:19:18Z" xsd:dateTime

[Term]
id: MP:0030414
name: tympanic membrane perforation
def: "presence of a hole or tear in the tympanic membrane (eardrum)" [https://www.emedicinehealth.com/perforated_eardrum/article_em.htm]
synonym: "eardrum perforation" EXACT []
synonym: "perforated eardrum" EXACT []
synonym: "perforated tympanic membrane" EXACT []
synonym: "ruptured eardrum" EXACT []
synonym: "tympanic membrane rupture" EXACT []
is_a: MP:0006018 ! abnormal tympanic membrane morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:27:30Z" xsd:dateTime

[Term]
id: MP:0030415
name: premature intermaxillary suture closure
def: "early closure of the anterior median suture between the two maxillae of the upper jawbone, located between the inferior border of the nasal aperture and the central incisor teeth" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of intermaxillary sutures" EXACT []
synonym: "intermaxillary suture synostosis" EXACT []
is_a: MP:0030390 ! premature facial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:36:37Z" xsd:dateTime

[Term]
id: MP:0030416
name: absent temporal bone zygomatic process
def: "missing the long, arched process that projects from the lower region of the squamous part of the temporal bone and articulates with the zygomatic bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent temporal zygomatic process" EXACT []
synonym: "absent zygomatic process of squamosal bone" EXACT []
synonym: "absent zygomatic process of temporal bone" EXACT []
is_a: MP:0030261 ! abnormal temporal bone zygomatic process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T12:53:26Z" xsd:dateTime

[Term]
id: MP:0030417
name: craniofacial hyperostosis
def: "excessive growth of the craniofacial bones" [HP:0004493]
synonym: "hyperostosis of craniofacial bones" EXACT []
synonym: "hypertrophy of craniofacial bones" EXACT []
synonym: "overgrowth of craniofacial bones" EXACT []
is_a: MP:0002116 ! abnormal craniofacial bone morphology
is_a: MP:0030222 ! hyperostosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T13:31:58Z" xsd:dateTime

[Term]
id: MP:0030418
name: facial hyperostosis
def: "excessive growth of the facial bones" [HP:0005465]
synonym: "excessive growth of facial skeleton" EXACT []
synonym: "hyperostosis of facial bones" EXACT []
synonym: "hyperostosis of facial skeleton" EXACT []
synonym: "hypertrophy of facial bones" EXACT []
synonym: "overgrowth of facial bones" EXACT []
synonym: "overgrowth of facial skeleton" EXACT []
is_a: MP:0005274 ! abnormal viscerocranium morphology
is_a: MP:0030417 ! craniofacial hyperostosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T13:48:46Z" xsd:dateTime

[Term]
id: MP:0030419
name: excessive cerumen
def: "excess buildup of cerumen, a yellowish waxy substance (earwax), in the external auditory canal" [HP:0030789]
synonym: "ear wax accumulation" EXACT []
synonym: "ear wax buildup" EXACT []
synonym: "earwax buildup" EXACT []
synonym: "excessive ear wax" EXACT []
synonym: "excessive earwax" EXACT []
is_a: MP:0006033 ! abnormal external auditory canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-17T14:18:07Z" xsd:dateTime

[Term]
id: MP:0030420
name: short basicranium
def: "decreased length of the anterior and/or posterior portions of the skull base" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cranial base length" EXACT []
synonym: "reduced cranial base length" EXACT []
synonym: "short cranial base" EXACT []
synonym: "short skull base" EXACT []
is_a: MP:0010029 ! abnormal basicranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T10:54:45Z" xsd:dateTime

[Term]
id: MP:0030421
name: tongue muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the tongue muscle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic lingual muscle" EXACT []
synonym: "hypoplastic tongue muscle" EXACT []
synonym: "lingual muscle hypoplasia" EXACT []
is_a: MP:0004136 ! abnormal tongue muscle morphology
is_a: MP:0009460 ! skeletal muscle hypoplasia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T11:03:43Z" xsd:dateTime

[Term]
id: MP:0030422
name: abnormal outer ear cartilage morphology
def: "any structural anomaly of the elastic cartilage components of the auricles and/or external acoustic meatus" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal external ear cartilage morphology" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology
is_a: MP:0006430 ! abnormal elastic cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T11:28:50Z" xsd:dateTime

[Term]
id: MP:0030423
name: abnormal pinna cartilage morphology
def: "any structural anomaly of the elastic cartilage component of the auricles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal auricular cartilage morphology" EXACT []
is_a: MP:0030422 ! abnormal outer ear cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T11:38:53Z" xsd:dateTime

[Term]
id: MP:0030424
name: premature palatomaxillary suture closure
def: "early closure of the transverse suture across the back of the hard palate that separates the maxillary shelf of the palate from the horizontal plates of the palatine bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of palatomaxillary suture" EXACT []
is_a: MP:0030390 ! premature facial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T11:49:38Z" xsd:dateTime

[Term]
id: MP:0030425
name: wide intermaxillary suture
def: "an abnormally increased width of the anterior median suture between the two maxillae of the upper jawbone for age-related norms" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad intermaxillary suture" EXACT []
synonym: "broadened intermaxillary suture" EXACT []
synonym: "large intermaxillary suture" EXACT []
synonym: "wide spaced intermaxillary suture" EXACT []
synonym: "widened intermaxillary suture" EXACT []
is_a: MP:0030194 ! abnormal intermaxillary suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T12:14:43Z" xsd:dateTime

[Term]
id: MP:0030426
name: facial muscle hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the facial muscle, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic facial muscles" EXACT []
is_a: MP:0009460 ! skeletal muscle hypoplasia
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T12:31:07Z" xsd:dateTime

[Term]
id: MP:0030427
name: abnormal neck muscle morphology
def: "any structural anomaly of any skeletal muscle that is part of the cervical (neck) region" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cervical muscle morphology" EXACT []
synonym: "abnormal neck musculature morphology" EXACT []
synonym: "neck muscle dysplasia" NARROW []
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0012719 ! abnormal neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T12:53:57Z" xsd:dateTime

[Term]
id: MP:0030428
name: abnormal scalene muscle morphology
def: "any structural anomaly of any of the three pairs of muscles in the lateral neck, namely the scalenus anterior, scalenus medius, and scalenus posterior; the scalenes are innervated by the cervical spinal nerves C4-C8, act as accessory muscles of respiration, and perform flexion at the neck" [http://teachmeanatomy.info/neck/muscles/scalene/, https://en.wikipedia.org/wiki/Scalene_muscles]
is_a: MP:0030427 ! abnormal neck muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T13:40:16Z" xsd:dateTime

[Term]
id: MP:0030429
name: abnormal levator nasolabialis muscle morphology
def: "any structural anomaly of the flat, thin muscle lying beneath the skin on the lateral surface of the maxillary bone; it arises from the maxillary bone, over the dorsum of the nose, and runs cranioventrally to insert partly on the wing of the nostril and partly into the lateral part of the upper lip; it acts to dilate the nostrils and elevate and retract the upper lip" [https://books.google.com/books?isbn=032332049X, UBERON:0011464]
synonym: "abnormal levator nasolabialis morpholgy" EXACT []
is_a: MP:0030039 ! abnormal facial muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T13:51:58Z" xsd:dateTime

[Term]
id: MP:0030430
name: absent levator nasolabialis muscle
def: "missing the flat, thin muscle that lies beneath the skin on the lateral surface of the maxillary bone; it arises from the maxillary bone, over the dorsum of the nose, and runs cranioventrally to insert partly on the wing of the nostril and partly into the lateral part of the upper lip; it acts to dilate the nostrils and elevate and retract the upper lip" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent levator nasolabialis" EXACT []
is_a: MP:0030429 ! abnormal levator nasolabialis muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T14:00:08Z" xsd:dateTime

[Term]
id: MP:0030431
name: wide metopic suture
def: "an abnormally increased width of the metopic suture for age-related norms" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad metopic suture" EXACT []
synonym: "large metopic suture" EXACT []
synonym: "wide frontal suture" EXACT []
synonym: "wide interfrontal suture" EXACT []
synonym: "wide median frontal suture" EXACT []
synonym: "wide mediofrontal suture" EXACT []
synonym: "wide spaced metopic suture" EXACT []
synonym: "widened metopic suture" EXACT []
is_a: MP:0003842 ! abnormal metopic suture morphology
is_a: MP:0030029 ! wide cranial sutures
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T14:31:04Z" xsd:dateTime

[Term]
id: MP:0030432
name: large cranial foramen ovale
def: "increased size of the oval-shaped opening in the middle cranial fossa located at the posterior base of the greater wing of the sphenoid bone, lateral to the lingula of the mandible" [https://orcid.org/0000-0002-6490-7723, https://radiopaedia.org/articles/foramen-ovale-skull]
synonym: "enlarged cranial foramen ovale" EXACT []
synonym: "enlarged foramen ovale cranii" EXACT []
synonym: "increased cranial foramen ovale size" EXACT []
is_a: MP:0030272 ! abnormal cranial foramen ovale morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T15:09:14Z" xsd:dateTime

[Term]
id: MP:0030433
name: large foramen rotundum
def: "increased size of the circular hole (foramen) in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa" [https://en.wikipedia.org/wiki/Foramen_rotundum, https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged foramen rotundum" EXACT []
synonym: "increased foramen rotundum size" EXACT []
synonym: "large foramen rotundum ossis sphenoidalis" EXACT []
synonym: "large round foramen" EXACT []
is_a: MP:0030271 ! abnormal foramen rotundum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-23T15:43:27Z" xsd:dateTime

[Term]
id: MP:0030434
name: premature maxillary-premaxillary suture closure
def: "early closure of the maxillary-premaxillary suture, the line of union of the two portions of the maxilla (pre- and postmaxilla)" [https://orcid.org/0000-0002-6490-7723]
synonym: "premature incisive suture closure" EXACT []
synonym: "premature premaxillary suture closure" EXACT []
synonym: "premature premaxillary-maxillary suture closure" EXACT []
synonym: "premature premaxillomaxillary suture closure" EXACT []
is_a: MP:0030390 ! premature facial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T10:16:57Z" xsd:dateTime

[Term]
id: MP:0030435
name: premature craniofacial suture closure
def: "early closure of any joint (suture) between cranial and/or facial bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of craniofacial sutures" EXACT []
synonym: "premature suture closure" EXACT []
is_a: MP:0003418 ! premature intramembranous bone ossification
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T10:27:18Z" xsd:dateTime

[Term]
id: MP:0030436
name: premature frontonasal suture closure
def: "early closure of the joint (suture) between the frontal bone and the two nasal bones" [https://orcid.org/0000-0002-6490-7723]
synonym: "early fusion of frontonasal sutures" EXACT []
synonym: "frontonasal suture synostosis" EXACT []
is_a: MP:0030435 ! premature craniofacial suture closure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T10:35:37Z" xsd:dateTime

[Term]
id: MP:0030437
name: abnormal osteoblast proliferation
def: "anomaly in the ability of osteoblasts to undergo expansion by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0005006 ! abnormal osteoblast physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T10:48:04Z" xsd:dateTime

[Term]
id: MP:0030438
name: increased osteoblast proliferation
def: "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0030437 ! abnormal osteoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T10:54:14Z" xsd:dateTime

[Term]
id: MP:0030439
name: decreased osteoblast proliferation
def: "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced osteoblast proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0030437 ! abnormal osteoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:00:26Z" xsd:dateTime

[Term]
id: MP:0030440
name: abnormal osteoblast apoptosis
def: "change in the timing or the number of osteoblasts undergoing programmed cell death; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005006 ! abnormal osteoblast physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:20:47Z" xsd:dateTime

[Term]
id: MP:0030441
name: increased osteoblast apoptosis
def: "increase in the number of osteoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0030440 ! abnormal osteoblast apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:27:37Z" xsd:dateTime

[Term]
id: MP:0030442
name: decreased osteoblast apoptosis
def: "reduction in the number of osteoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced osteoblast apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0030440 ! abnormal osteoblast apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:31:51Z" xsd:dateTime

[Term]
id: MP:0030443
name: abnormal cranial synchondrosis
def: "any anomaly in the development of cartilaginous joints or growth centers between bones of the skull base by the formation of hyaline cartilage which is abundant during the growth phase and ultimately ossifies during skeletal maturation; synchondroses are composed of mirror-image growth plates with a central resting zone, proliferative zones, and hypertrophic zones on both sides; in mouse, there are two synchondroses in the midline cranial base, the sphenooccipital and presphenoidal synchondroses" [PMID:27250655, PMID:28827837]
synonym: "abnormal cranial synchondroses" EXACT []
is_a: MP:0004053 ! abnormal synchondrosis
is_a: MP:0030467 ! abnormal cranial cartilage development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:36:49Z" xsd:dateTime

[Term]
id: MP:0030444
name: premature cranial synchondrosis closure
def: "early fusion or ossification of one or more cranial base synchondroses relative to age- and gender-matched controls; can lead to midface hypoplasia, as seen in patients with specific forms of syndromic craniosynostosis" [PMID:24480760]
synonym: "precocious cranial synchondrosis closure" EXACT []
synonym: "premature closure of cranial base synchondroses" EXACT []
synonym: "premature cranial synchondrosis fusion" EXACT []
synonym: "premature ossification of cranial synchondroses" EXACT []
is_a: MP:0003417 ! premature endochondral bone ossification
is_a: MP:0030443 ! abnormal cranial synchondrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T11:45:48Z" xsd:dateTime

[Term]
id: MP:0030445
name: abnormal sphenooccipital synchondrosis
def: "any anomaly in the development of the cartilaginous joint (growth center) between the basioccipital and basisphenoid bones that is an important driver of facial and cranial base growth; sphenooccipital synchondroses are among the last to fuse and may remain patent until early adulthood" [https://www.merriam-webster.com/medical/spheno-occipital%20synchondrosis, PMID:22777037, PMID:24255553]
synonym: "abnormal SOS" EXACT []
synonym: "abnormal spheno-occipital synchondrosis" EXACT []
is_a: MP:0030443 ! abnormal cranial synchondrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T12:10:05Z" xsd:dateTime

[Term]
id: MP:0030446
name: premature sphenooccipital synchondrosis closure
def: "early closure or ossification of the sphenooccipital synchondrosis relative to age- and gender-matched controls; premature fusion has been associated with midface hypoplasia in animal models and patients with specific forms of syndromic craniosynostosis" [PMID:24406578, PMID:24480760]
synonym: "precocious sphenooccipital synchondrosis closure" EXACT []
synonym: "premature fusion of sphenooccipital synchondrosis" EXACT []
synonym: "premature ossification of sphenooccipital synchondrosis" EXACT []
synonym: "premature SOS closure" EXACT []
synonym: "premature spheno-occipital synchondrosis closure" EXACT []
is_a: MP:0030444 ! premature cranial synchondrosis closure
is_a: MP:0030445 ! abnormal sphenooccipital synchondrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T12:47:52Z" xsd:dateTime

[Term]
id: MP:0030447
name: abnormal presphenoid synchondrosis
def: "any anomaly in the development of the cartilaginous joint (growth center) between the presphenoid and basisphenoid bones of the skull base" [PMID:23179633]
synonym: "abnormal intersphenoid synchondrosis" EXACT []
synonym: "abnormal intersphenoidal synchondrosis" EXACT []
synonym: "abnormal pre-sphenoid synchondrosis" EXACT []
synonym: "abnormal presphenoidal synchondrosis" EXACT []
synonym: "abnormal PSS" EXACT []
is_a: MP:0030443 ! abnormal cranial synchondrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T13:00:21Z" xsd:dateTime

[Term]
id: MP:0030448
name: premature presphenoid synchondrosis closure
def: "early closure or ossification of the presphenoid synchondrosis relative to age- and gender-matched controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "precocious presphenoid synchondrosis closure" EXACT []
synonym: "premature fusion of presphenoid synchondrosis" EXACT []
synonym: "premature intersphenoid synchondrosis closure" EXACT []
synonym: "premature intersphenoidal synchondrosis closure" EXACT []
synonym: "premature ossification of presphenoid synchondrosis" EXACT []
synonym: "premature pre-sphenoid synchondrosis closure" EXACT []
synonym: "premature presphenoidal synchondrosis closure" EXACT []
synonym: "premature PSS closure" EXACT []
is_a: MP:0030444 ! premature cranial synchondrosis closure
is_a: MP:0030447 ! abnormal presphenoid synchondrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-28T13:06:34Z" xsd:dateTime

[Term]
id: MP:0030449
name: tooth ankylosis
def: "solid fixation of a tooth resulting from fusion of the dental cementum and alveolar bone, with obliteration of the periodontal ligament" [RDO:0001938]
synonym: "ankylosis of teeth" EXACT []
synonym: "dental ankyloses" EXACT []
synonym: "dental ankylosis" EXACT []
synonym: "dentoalveolar ankyloses" EXACT []
synonym: "dentoalveolar ankylosis" EXACT []
synonym: "teeth ankyloses" EXACT []
synonym: "teeth ankylosis" EXACT []
synonym: "tooth ankyloses" EXACT []
is_a: MP:0003933 ! abnormal cementum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T12:43:22Z" xsd:dateTime

[Term]
id: MP:0030450
name: abnormal enamel mineralization
def: "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
synonym: "abnormal enamel calcification" EXACT []
synonym: "enamel mineralization defects" EXACT []
is_a: MP:0002817 ! abnormal tooth mineralization
is_a: MP:0030544 ! abnormal enamel development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:03:30Z" xsd:dateTime

[Term]
id: MP:0030451
name: abnormal dentin mineralization
def: "anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188]
synonym: "abnormal dentin calcification" EXACT []
synonym: "dentin mineralization defects" EXACT []
is_a: MP:0002817 ! abnormal tooth mineralization
is_a: MP:0030542 ! abnormal dentin development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:08:47Z" xsd:dateTime

[Term]
id: MP:0030452
name: abnormal cementum mineralization
def: "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum" [GO:0071529]
synonym: "abnormal cementum calcification" EXACT []
synonym: "cementum mineralization defects" EXACT []
is_a: MP:0002817 ! abnormal tooth mineralization
is_a: MP:0030547 ! abnormal cementum development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:15:42Z" xsd:dateTime

[Term]
id: MP:0030453
name: abnormal odontoblast morphology
def: "any structural anomaly of the skeletogenic cell on the outer surface of the dental pulp that secretes dentin matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell" [CL:0000060, GO:0071895]
is_a: MP:0013250 ! abnormal dental pulp morphology
is_a: MP:0030542 ! abnormal dentin development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:24:38Z" xsd:dateTime

[Term]
id: MP:0030454
name: abnormal odontoblast number
def: "deviation from the normal number of skeletogenic cells on the outer surface of the dental pulp that secrete dentin matrix, are derived from the odontogenic papilla, and develop from preodontoblast cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030453 ! abnormal odontoblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:30:28Z" xsd:dateTime

[Term]
id: MP:0030455
name: increased odontoblast number
def: "greater than normal number of the skeletogenic cells on the outer surface of the dental pulp that secrete dentin matrix, are derived from the odontogenic papilla, and develop from preodontoblast cells" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030454 ! abnormal odontoblast number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:36:25Z" xsd:dateTime

[Term]
id: MP:0030456
name: abnormal odontoblast differentiation
def: "anomaly in the process by which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a skeletogenic cell on the outer surface of the dental pulp that secretes dentin matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell" [CL:0000060, GO:0071895]
is_a: MP:0030453 ! abnormal odontoblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T13:46:39Z" xsd:dateTime

[Term]
id: MP:0030457
name: abnormal molar cusp morphology
def: "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003932 ! abnormal molar crown morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T14:01:10Z" xsd:dateTime

[Term]
id: MP:0030458
name: abnormal tooth wear
def: "change in the progression or severity of loss of tooth substance, usually resulting from abrasion, attrition and erosion acting singly or concurrently; tooth wear is a normal, age-dependent physiological process that leads to surface loss of dental hard tissues" [https://www.igi-global.com/dictionary/tooth-wear/45534, https://www.slideshare.net/aneeqa_yaqub/tooth-wear-and-its-types, PMID:22240686]
synonym: "abnormal dental wear" EXACT []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T14:16:51Z" xsd:dateTime

[Term]
id: MP:0030459
name: abnormal tooth attrition
def: "change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]
synonym: "abnormal dental attrition" EXACT []
synonym: "abnormal occlusal tooth wear" EXACT []
synonym: "abnormal occlusal wear" EXACT []
is_a: MP:0030458 ! abnormal tooth wear
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-11-30T14:25:19Z" xsd:dateTime

[Term]
id: MP:0030460
name: enamel pits
def: "presence of small depressions in the dental enamel" [HP:0009722]
synonym: "dental enamel pits" EXACT []
synonym: "dental enamel pitting" EXACT []
synonym: "pitting of tooth enamel" EXACT []
synonym: "tooth enamel pits" EXACT []
is_a: MP:0002576 ! abnormal enamel morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T12:08:37Z" xsd:dateTime

[Term]
id: MP:0030461
name: abnormal sphenosquamosal suture morphology
def: "any structural anomaly of the vertical cranial suture located between the sphenoid and temporal bones bilaterally; it is formed by the articulation between the posterior border of the greater wing of the sphenoid bone and the anterior border of the squamous part of the temporal bone" [https://radiopaedia.org/articles/sphenosquamosal-suture]
is_a: MP:0002835 ! abnormal cranial suture morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T12:16:47Z" xsd:dateTime

[Term]
id: MP:0030462
name: tooth abscess
def: "a pocket of pus localized within a region of a tooth, usually caused by a bacterial infection" [HP:0030757, https://www.mayoclinic.org/diseases-conditions/tooth-abscess/symptoms-causes/syc-20350901]
synonym: "dental abscess" EXACT []
synonym: "dentoalveolar abscess" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T12:27:19Z" xsd:dateTime

[Term]
id: MP:0030463
name: apical tooth abscess
def: "a tooth abscess that occurs at or around the tip of the root (apex) of a tooth; may result from pulp infection due to carious lesion or pulp necrosis resulting from injury" [HP:0030758, https://medical-dictionary.thefreedictionary.com/periapical+abscess]
synonym: "apical dental abscess" EXACT []
synonym: "apical dentoalveolar abscess" EXACT []
synonym: "periapical tooth abscess" EXACT []
is_a: MP:0030462 ! tooth abscess
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T12:35:57Z" xsd:dateTime

[Term]
id: MP:0030464
name: abnormal cranial cartilage morphology
def: "any structural anomaly of any cartilage element that is part of the cranial skeleton" [UBERON:0003933]
synonym: "abnormal cranium cartilage morphology" EXACT []
is_a: MP:0000163 ! abnormal cartilage morphology
is_a: MP:0000438 ! abnormal cranium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T12:46:17Z" xsd:dateTime

[Term]
id: MP:0030465
name: absent oval window
def: "missing the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent fenestra of the vestibule" EXACT []
synonym: "absent fenestra ovalis" EXACT []
synonym: "absent fenestra vestibuli" EXACT []
synonym: "absent vestibular window" EXACT []
is_a: MP:0004479 ! abnormal oval window morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T13:11:06Z" xsd:dateTime

[Term]
id: MP:0030466
name: alveolar process atrophy
def: "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "alveolar bone atrophy" EXACT []
synonym: "alveolar bone loss" EXACT []
synonym: "alveolar bone resorption" EXACT []
synonym: "alveolar ridge atrophy" EXACT []
is_a: MP:0004189 ! abnormal alveolar process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T13:20:17Z" xsd:dateTime

[Term]
id: MP:0030467
name: abnormal cranial cartilage development
def: "anomaly in the formation of any cartilage element that is part of the cranial skeleton" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cranial cartilage formation" EXACT []
synonym: "abnormal cranial chondrogenesis" EXACT []
synonym: "abnormal cranium cartilage formation" EXACT []
synonym: "cranial dyschondrogenesis" EXACT []
is_a: MP:0000164 ! abnormal cartilage development
is_a: MP:0030464 ! abnormal cranial cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-04T13:53:52Z" xsd:dateTime

[Term]
id: MP:0030468
name: abnormal carotid canal morphology
def: "any structural anomaly of the passageway within the petrous temporal bone that transmits the internal carotid artery and sympathetic plexus; its inferior opening is the carotid foramen situated anteriorly to the jugular fossa and medially to the tympanic plate; the carotid canal is initially directed superiorly, then turns anteromedially to reach up to the petrous apex, runs within the petrous bone, and opens into the middle cranial fossa superior to the foramen lacerum" [https://radiopaedia.org/articles/carotid-canal]
is_a: MP:0030308 ! abnormal middle cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
is_a: MP:0030319 ! abnormal temporal bone petrous part morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-05T12:11:08Z" xsd:dateTime

[Term]
id: MP:0030469
name: optic canal stenosis
def: "abnormal narrowing or constriction of the short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the ophthalmic artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "constricted optic canal" EXACT []
synonym: "narrow optic canal" EXACT []
synonym: "narrow optic foramen" EXACT []
synonym: "narrow optic foramina" EXACT []
synonym: "narrowed optic canal" EXACT []
is_a: MP:0010704 ! abnormal optic canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-05T12:36:23Z" xsd:dateTime

[Term]
id: MP:0030470
name: abnormal jugular foramen morphology
def: "any structural anomaly of the large irregular opening from the posterior cranial fossa that is bounded anteriorly by the petrous part of the temporal bone and posteriorly by the jugular notch of the occipital bone; it transmits the inferior petrosal sinus, the glossopharyngeal, vagus, and accessory nerves, and the internal jugular vein" [https://www.merriam-webster.com/medical/jugular%20foramen, UBERON:0005456]
synonym: "abnormal posterior lacerate foramen morphology" EXACT []
is_a: MP:0030309 ! abnormal posterior cranial fossa morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-05T12:47:37Z" xsd:dateTime

[Term]
id: MP:0030471
name: abnormal ameloblast differentiation
def: "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a functional ameloblast, a tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ of a developing tooth involved with the formation of enamel matrix" [GO:0036305, PMID:19090561]
synonym: "abnormal ameloblast cell differentiation" EXACT []
is_a: MP:0002650 ! abnormal ameloblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T11:54:55Z" xsd:dateTime

[Term]
id: MP:0030472
name: fused teeth
def: "union of two separately developing tooth germs typically leading to one less tooth than normal in the affected arch" [HP:0011090, PMID:18167487]
synonym: "fusion of teeth" EXACT []
synonym: "joined teeth" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:10:26Z" xsd:dateTime

[Term]
id: MP:0030473
name: fused molars
def: "union of two adjacent molar teeth in the maxilla and/or mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "fusion of molar teeth" EXACT []
synonym: "joined molars" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0030472 ! fused teeth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:19:06Z" xsd:dateTime

[Term]
id: MP:0030474
name: fused incisors
def: "union of two adjacent incisor teeth in the maxilla and/or mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "fusion of incisor teeth" EXACT []
synonym: "joined incisors" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0030472 ! fused teeth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:24:55Z" xsd:dateTime

[Term]
id: MP:0030475
name: fused lower incisors
def: "union of two adjacent incisor teeth in the mandible" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused lower jaw incisors" EXACT []
synonym: "fused mandibular incisors" EXACT []
synonym: "joined lower incisors" EXACT []
synonym: "joined mandibular incisors" EXACT []
is_a: MP:0030136 ! abnormal lower incisor morphology
is_a: MP:0030474 ! fused incisors
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:29:01Z" xsd:dateTime

[Term]
id: MP:0030476
name: fused upper incisors
def: "union of two adjacent incisor teeth in the maxilla" [https://orcid.org/0000-0002-6490-7723]
synonym: "fused maxillary incisors" EXACT []
synonym: "fused upper jaw incisors" EXACT []
synonym: "joined maxillary incisors" EXACT []
synonym: "joined upper incisors" EXACT []
is_a: MP:0030137 ! abnormal upper incisor morphology
is_a: MP:0030474 ! fused incisors
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:35:18Z" xsd:dateTime

[Term]
id: MP:0030477
name: abnormal osteocyte physiology
def: "any functional anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in a small cavity called lacuna and that extends cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005006 ! abnormal osteoblast physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:55:17Z" xsd:dateTime

[Term]
id: MP:0030478
name: abnormal osteocyte apoptosis
def: "change in the timing or the number of osteocytes undergoing programmed cell death; an osteocyte is a mature osteoblast that has become embedded in the bone matrix (osteoid) in a small cavity called lacuna and that extends cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030440 ! abnormal osteoblast apoptosis
is_a: MP:0030477 ! abnormal osteocyte physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T12:59:08Z" xsd:dateTime

[Term]
id: MP:0030479
name: increased osteocyte apoptosis
def: "increase in the number of osteocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030441 ! increased osteoblast apoptosis
is_a: MP:0030478 ! abnormal osteocyte apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:05:06Z" xsd:dateTime

[Term]
id: MP:0030480
name: decreased osteocyte apoptosis
def: "reduction in the number of osteocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced osteocyte apoptosis" EXACT []
is_a: MP:0030442 ! decreased osteoblast apoptosis
is_a: MP:0030478 ! abnormal osteocyte apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:09:05Z" xsd:dateTime

[Term]
id: MP:0030481
name: abnormal osteocyte number
def: "deviation from the average number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008753 ! abnormal osteocyte morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:15:59Z" xsd:dateTime

[Term]
id: MP:0030482
name: increased osteocyte number
def: "greater than average number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030481 ! abnormal osteocyte number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:20:25Z" xsd:dateTime

[Term]
id: MP:0030483
name: decreased osteocyte number
def: "reduction in the number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced osteocyte number" EXACT []
is_a: MP:0030481 ! abnormal osteocyte number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:24:09Z" xsd:dateTime

[Term]
id: MP:0030484
name: abnormal osteocyte lacuna morphology
def: "any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna]
synonym: "abnormal bone lacuna morphology" BROAD []
synonym: "abnormal osteocyte lacunae morphology" EXACT []
synonym: "abnormal osteocytic lacunae morphology" EXACT []
is_a: MP:0030485 ! abnormal osteocyte lacunocanalicular system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T13:44:22Z" xsd:dateTime

[Term]
id: MP:0030485
name: abnormal osteocyte lacunocanalicular system morphology
def: "any structural anomaly of the large network intercommunicating the lacunae and canaliculi which contain the osteocytes and their cytoplasmic processes within the mineralized bone matrix" [PMID:22928392]
synonym: "abnormal lacuno-canalicular system morphology" EXACT []
synonym: "abnormal osteocyte lacuno-canalicular system morphology" EXACT []
is_a: MP:0003795 ! abnormal bone structure
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T14:24:18Z" xsd:dateTime

[Term]
id: MP:0030486
name: abnormal osteocyte canaliculus morphology
def: "any structural anomaly of the slender canals situated between the lacunae of ossified bone where osteocyte cytoplasmic (dendritic) processes reside; osteocyte canaliculi are used for exchange of nutrients and waste products through gap junctions" [https://en.wikipedia.org/wiki/Bone_canaliculus, https://en.wikipedia.org/wiki/Osteocyte]
synonym: "abnormal osteocyte canaliculi morphology" EXACT []
is_a: MP:0030485 ! abnormal osteocyte lacunocanalicular system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T14:31:59Z" xsd:dateTime

[Term]
id: MP:0030487
name: abnormal osteocyte dendritic process morphology
def: "any structural anomaly of the long, slender cytoplasmic processes by which mature osteocytes communicate with one another, receive mechanosensory signals and participate in the regulation of bone turnover; these processes radiate from the osteocyte cell body, run along narrow canaliculi, and are linked to other neighboring osteocytes processes by gap junctions, as well as to cytoplasmic processes of osteoblasts and bone lining cells on the bone surface" [https://www.hindawi.com/journals/bmri/2015/421746/, PMID:24419319]
synonym: "abnormal osteocyte cytoplasmic process morphology" EXACT []
synonym: "abnormal osteocyte dendrite morphology" EXACT []
synonym: "abnormal osteocyte process morphology" EXACT []
is_a: MP:0008753 ! abnormal osteocyte morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-07T14:40:37Z" xsd:dateTime

[Term]
id: MP:0030488
name: abnormal tooth socket morphology
def: "any structural anomaly of any of the cavities or sockets in the alveolar process of the mandible or maxilla, in which the roots of the teeth are held by fibers of the periodontal ligament" [https://en.wikipedia.org/wiki/Dental_alveolus, UBERON:0003686]
synonym: "abnormal dental alveoli morphology" EXACT []
synonym: "abnormal dental alveolus morphology" EXACT []
synonym: "abnormal tooth alveolus morphology" EXACT []
is_a: MP:0004189 ! abnormal alveolar process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T08:23:31Z" xsd:dateTime

[Term]
id: MP:0030489
name: abnormal molar socket morphology
def: "any structural anomaly of any of the cavities or sockets in the alveolar process of the mandible or maxilla, in which the roots of molar teeth are held by fibers of the periodontal ligament" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal molar alveolus morphology" EXACT []
synonym: "abnormal molar tooth alveolus morphology" EXACT []
synonym: "abnormal molar tooth socket morphology" EXACT []
is_a: MP:0030488 ! abnormal tooth socket morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T08:32:00Z" xsd:dateTime

[Term]
id: MP:0030490
name: periodontal pocket
def: "a pathologic deepening of the gingival sulcus as a result of apical migration of the junctional epithelium and the destruction of alveolar bone and periodontal ligament fiber bundles" [https://books.google.com/books?isbn=0781784875]
synonym: "periodontal pockets" EXACT []
is_a: MP:0030131 ! abnormal periodontium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T08:51:54Z" xsd:dateTime

[Term]
id: MP:0030491
name: dental pulp stones
def: "nodular, calcified masses appearing in either or both the coronal and root portion of the pulp organ in teeth" [HP:0003771, https://en.wikipedia.org/wiki/Pulp_stone]
synonym: "dental pulp calcification" EXACT []
synonym: "pulp denticles" EXACT []
synonym: "pulp endoliths" EXACT []
synonym: "pulp stones" EXACT []
synonym: "pulpoliths" EXACT []
is_a: MP:0013250 ! abnormal dental pulp morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T09:18:43Z" xsd:dateTime

[Term]
id: MP:0030492
name: abnormal dentoalveolar joint morphology
def: "any structural anomaly of the specialized peg-in-socket fibrous joint between the root of a tooth and the socket in the maxilla or mandible; this type of joint permits very limited or no movement under normal conditions and is functionally classified as a synarthrosis" [https://en.wikipedia.org/wiki/Fibrous_joint#Gomphosis]
synonym: "abnormal dento-alveolar joint morphology" EXACT []
synonym: "abnormal dento-alveolar syndesmosis morphology" EXACT []
synonym: "abnormal gomphosis morphology" EXACT []
is_a: MP:0000454 ! abnormal jaw morphology
is_a: MP:0030878 ! abnormal fibrous joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T09:37:57Z" xsd:dateTime

[Term]
id: MP:0030493
name: abnormal tooth root morphology
def: "any structural anomaly of the part of a tooth that is implanted in the gum; the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal dental root morphology" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T09:48:15Z" xsd:dateTime

[Term]
id: MP:0030494
name: abnormal molar root morphology
def: "any structural anomaly of the part of a molar tooth that is implanted in the gum" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal molar tooth root morphology" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0030493 ! abnormal tooth root morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T09:58:00Z" xsd:dateTime

[Term]
id: MP:0030495
name: absent tooth root
def: "absence of or failure to develop the part of a tooth that is implanted in the gum; normally, the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "absence of tooth root" EXACT []
synonym: "absent dental root" EXACT []
synonym: "agenesis of tooth root" EXACT []
synonym: "aplasia of tooth root" EXACT []
synonym: "rootless teeth" EXACT []
synonym: "rootless tooth" EXACT []
is_a: MP:0030493 ! abnormal tooth root morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T10:15:17Z" xsd:dateTime

[Term]
id: MP:0030496
name: taurodontia
def: "a developmental anomaly involving molar teeth, whereby the body of the tooth and pulp chamber is enlarged vertically at the expense of the roots and the root canal length; characteristic features include an enlarged pulp chamber, absence of the usual constriction at the cemento-enamel junction, and apical shift of the pulp chamber floor and furcation area down the root" [https://en.wikipedia.org/wiki/Taurodontism, PMID:24574680]
synonym: "taurodont" EXACT []
synonym: "taurodontism" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0013250 ! abnormal dental pulp morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T11:45:11Z" xsd:dateTime

[Term]
id: MP:0030497
name: short tooth root
def: "decreased length of the part of a tooth that is implanted in the gum; the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased length of dental root" EXACT []
synonym: "decreased length of tooth root" EXACT []
synonym: "short dental root" EXACT []
synonym: "short dental roots" EXACT []
synonym: "short tooth roots" EXACT []
is_a: MP:0030493 ! abnormal tooth root morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-11T12:53:42Z" xsd:dateTime

[Term]
id: MP:0030498
name: abnormal dental lamina morphology
def: "any structural anomaly of the U-shaped stripe of thickened oral epithelium marking the future tooth row; the primary dental lamina is the earliest morphological structure of the tooth formed in the embryo; local thickenings of the dental lamina from which individual teeth are initiated are known as tooth placodes" [https://www.ncbi.nlm.nih.gov/books/NBK27071/]
synonym: "abnormal embryonic dental lamina morphology" EXACT []
synonym: "abnormal odontogenic band morphology" EXACT []
synonym: "abnormal primary dental lamina morphology" EXACT []
is_a: MP:0000116 ! abnormal tooth development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T11:50:47Z" xsd:dateTime

[Term]
id: MP:0030499
name: conical tooth
def: "a peg-shaped (coniform) tooth whose sides converge or taper together incisally" [HP:0000698]
synonym: "cone-shaped tooth" EXACT []
synonym: "conical teeth" EXACT []
synonym: "conoid tooth" EXACT []
synonym: "peg tooth" EXACT []
synonym: "peg-like tooth" EXACT []
synonym: "peg-shaped teeth" EXACT []
synonym: "peg-shaped tooth" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:05:57Z" xsd:dateTime

[Term]
id: MP:0030500
name: conical molar
def: "a molar tooth whose sides converge or taper together incisally forming a peg-shaped (coniform) crown" [https://orcid.org/0000-0002-6490-7723]
synonym: "cone-shaped molar" EXACT []
synonym: "conical molar tooth" EXACT []
synonym: "conical molars" EXACT []
synonym: "conoid molar" EXACT []
synonym: "peg molar" EXACT []
synonym: "peg-like molar" EXACT []
synonym: "peg-shaped molar" EXACT []
synonym: "peg-shaped molars" EXACT []
is_a: MP:0002689 ! abnormal molar morphology
is_a: MP:0030499 ! conical tooth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:15:38Z" xsd:dateTime

[Term]
id: MP:0030501
name: abnormal incisive canal morphology
def: "any structural anomaly of any of several bony canals leading from the floor of the nasal cavity into the incisive fossa on the palatal surface of the maxilla; they convey the nasopalatine nerves and branches of the greater palatine arteries that anastomose with the septal branch of the sphenopalatine artery" [https://radiopaedia.org/articles/incisive-canal, UBERON:0006672]
synonym: "abnormal nasopalatine canal morphology" EXACT []
is_a: MP:0003756 ! abnormal hard palate morphology
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:23:23Z" xsd:dateTime

[Term]
id: MP:0030502
name: abnormal incisive foramen morphology
def: "any structural anomaly of any oral opening of the nasopalatine (incisive) canal; it is located in the maxilla in the incisive fossa, midline in the palate posterior to the central incisors, at the junction of the medial palatine and incisive sutures; it can be single or multiple; it transmits the greater palatine artery and vein from the oral to the nasal cavity and the nasopalatine nerve in the opposite direction" [https://radiopaedia.org/articles/incisive-foramen, UBERON:0012315]
synonym: "abnormal anterior palatine foramen morphology" EXACT []
synonym: "abnormal nasopalatine foramen morphology" EXACT []
is_a: MP:0030310 ! abnormal cranial foramen morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:37:30Z" xsd:dateTime

[Term]
id: MP:0030503
name: abnormal tooth neck morphology
def: "any structural anomaly of the slightly constricted part of a tooth between the crown and the root" [https://medical-dictionary.thefreedictionary.com/tooth+neck, UBERON:0015181]
synonym: "abnormal cervix dentis morphology" EXACT []
synonym: "abnormal collum dentis morphology" EXACT []
synonym: "abnormal dental neck morphology" EXACT []
synonym: "abnormal tooth cervix morphology" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:51:35Z" xsd:dateTime

[Term]
id: MP:0030504
name: abnormal cementoenamel junction morphology
def: "any anomaly of the interface between the cementum and enamel at the cervical region (neck) of a tooth; it represents the anatomic limit or line of division between the crown and root surface" [https://medical-dictionary.thefreedictionary.com/cementoenamel+junction]
synonym: "abnormal CEJ morphology" EXACT []
synonym: "abnormal cemento-enamel junction morphology" EXACT []
synonym: "abnormal cervical line morphology" EXACT []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology
is_a: MP:0030503 ! abnormal tooth neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T13:59:35Z" xsd:dateTime

[Term]
id: MP:0030505
name: tooth impaction
def: "cessation of eruption of a tooth caused by a clinically or radiographically detectable physical barrier in the eruption path or by an ectopic position of the tooth; an impacted tooth is one that is unable to fully erupt in its proper location because it is blocked by tissue, bone or another tooth" [https://books.google.com/books?isbn=9350252147, https://en.wikipedia.org/wiki/Tooth_impaction]
synonym: "dental impaction" EXACT []
synonym: "impacted teeth" NARROW []
synonym: "impacted tooth" EXACT []
is_a: MP:0000121 ! failure of tooth eruption
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T14:30:40Z" xsd:dateTime

[Term]
id: MP:0030506
name: abnormal dental follicle morphology
def: "any structural anomaly of the loose ectomesenchyme-derived connective tissue sac that surrounds the enamel organ and the dental papilla of the developing tooth germ before eruption; it is believed that this tissue contains stem cells and lineage-committed progenitor cells or precursor cells for cementoblasts, periodontal ligament (PDL) cells and osteoblasts; dental follicle cells form the PDL by differentiating into PDL fibroblasts that secrete collagen and interact with fibers on the surface of adjacent bone and cementum" [PMID:21035344]
synonym: "abnormal dental sac morphology" EXACT []
synonym: "abnormal tooth follicle morphology" EXACT []
is_a: MP:0000116 ! abnormal tooth development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T14:58:52Z" xsd:dateTime

[Term]
id: MP:0030507
name: abnormal dental papilla morphology
def: "any structural anomaly of the condensation of ectomesenchymal cells called odontoblasts seen in histologic sections of a developing tooth; the dental papilla lies below a cellular aggregation known as the enamel organ and differentiates into the dentin and dental pulp" [https://en.wikipedia.org/wiki/Dental_papilla]
is_a: MP:0000116 ! abnormal tooth development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-15T15:29:10Z" xsd:dateTime

[Term]
id: MP:0030508
name: abnormal dental epithelium morphology
def: "any structural anomaly of the epithelium that is part of a developing tooth or dental (enamel) organ" [UBERON:0003843]
synonym: "abnormal odontogenic epithelium morphology" EXACT []
synonym: "abnormal tooth epithelium morphology" EXACT []
is_a: MP:0010747 ! abnormal enamel organ morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T10:40:36Z" xsd:dateTime

[Term]
id: MP:0030509
name: increased number of epithelial cell rests of Malassez
def: "increased number of epithelial cell remnants derived from the fragmentation of Hertwig's epithelial root sheath during root development that persist in the periodontal ligament close to the cementum surface" [CL:0002166, http://dental.pitt.edu/periohistology-glossary#cellrestsofmalassez]
synonym: "increased number of epithelial cells of Malassez" EXACT []
synonym: "increased number of epithelial rests of Malassez" EXACT []
is_a: MP:0003668 ! abnormal periodontal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T11:24:57Z" xsd:dateTime

[Term]
id: MP:0030510
name: abnormal tooth placode morphology
def: "any structural anomaly of the local thickening that is formed within the primary dental lamina and grows into a solid epithelial tooth bud that invades the underlying mesenchyme; the placodes consist of thickened epithelium and underlying neural crest derived mesenchyme, and they function as the first signaling centers of the tooth" [GO:0060790, https://www.ncbi.nlm.nih.gov/books/NBK27071/, PMID:26755699]
comment: The term placode has not been universally adopted in the field of tooth development research; in mouse, stages prior to bud (E11–E12.5) have often been collectively referred to as the epithelial thickening, dental lamina, or simply initiation stage {xref="PMID:24487243"}
synonym: "abnormal dental anlage morphology" EXACT []
synonym: "abnormal dental placode morphology" EXACT []
synonym: "abnormal dental primordium morphology" EXACT []
synonym: "abnormal odontogenic placode morphology" EXACT []
synonym: "abnormal tooth anlage morphology" EXACT []
synonym: "abnormal tooth primordium morphology" EXACT []
is_a: MP:0000116 ! abnormal tooth development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T12:12:26Z" xsd:dateTime

[Term]
id: MP:0030511
name: abnormal dentinoenamel junction morphology
def: "any structural anomaly of the interface that joins two distinct calcified tissues, enamel and dentin; it presents a scalloped contour, with its concave side toward the enamel and the convex side toward the dentin, thought to increase adherence of the enamel to the dentin, especially in areas of occlusal stress; DEJ plays a key role in resisting crack propagation from enamel to dentin" [https://books.google.com/books?isbn=1118938313, https://en.wikipedia.org/wiki/Dentinoenamel_junction]
synonym: "abnormal amelo-dentinal junction morphology" EXACT []
synonym: "abnormal amelodentinal junction morphology" EXACT []
synonym: "abnormal DEJ morphology" EXACT []
synonym: "abnormal dentin-enamel junction morphology" EXACT []
synonym: "abnormal dentino-enamel junction morphology" EXACT []
is_a: MP:0003930 ! abnormal tooth hard tissue morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T12:50:08Z" xsd:dateTime

[Term]
id: MP:0030512
name: abnormal Tomes' process morphology
def: "any structural anomaly of the pyramidal extension at the apical pole of a secretory ameloblast that plays an important role in organizing the enamel crystals into a complex network of rod (prism) and interrod enamel; Tomes' processes interdigitate with the surface of the forming enamel giving it a picket fence appearance and determine the orientation of the newly formed (nucleated) enamel hydroxyapatite crystals; as the secretory stage ends, Tomes' processes are lost and accordingly the last formed layers of enamel are rodless or prismless" [https://books.google.com/books?isbn=0199533016, PMID:20016979]
is_a: MP:0002650 ! abnormal ameloblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T13:05:56Z" xsd:dateTime

[Term]
id: MP:0030513
name: short Tomes' process
def: "decreased length of the pyramidal extension at the apical pole of a secretory ameloblast that plays an important role in organizing the enamel crystals into a complex network of rod (prism) and interrod enamel" [https://orcid.org/0000-0002-6490-7723]
synonym: "short Tomes' processes" EXACT []
is_a: MP:0030512 ! abnormal Tomes' process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T13:17:04Z" xsd:dateTime

[Term]
id: MP:0030514
name: absent Tomes' process
def: "failure to form the pyramidal extension at the apical pole of a secretory ameloblast that plays an important role in organizing the enamel crystals into a complex network of rod (prism) and interrod enamel" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent Tomes' processes" EXACT []
is_a: MP:0030512 ! abnormal Tomes' process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T13:19:22Z" xsd:dateTime

[Term]
id: MP:0030515
name: periodontal ligament necrosis
def: "morphological changes resulting from pathological death of periodontal ligament tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "necrotic periodontal ligament" EXACT []
is_a: MP:0003668 ! abnormal periodontal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T13:27:25Z" xsd:dateTime

[Term]
id: MP:0030516
name: abnormal junctional epithelium morphology
def: "any structural anomaly of the collar-like band of non-keratinized squamous epithelium that attaches the gingival soft tissue to the tooth surface; the term epithelial attachment refers to the attachment apparatus, i.e. the internal basal lamina and hemidesmosomes, that connects the junctional epithelium (JE) to the tooth surface; in the initiation of periodontitis, JE detaches from the tooth surface and converts gradually, by sprouting laterally and migrating apically, to pathological pocket epithelium" [http://dental.pitt.edu/junctional-epithelium, https://books.google.com/books?isbn=0123977630, PMID:25911094]
is_a: MP:0020460 ! abnormal gum epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T13:54:10Z" xsd:dateTime

[Term]
id: MP:0030517
name: detached junctional epithelium
def: "partial or complete detachment of the junctional epithelium from the tooth surface, typically leading to periodontal pocket formation" [https://books.google.com/books?isbn=0123977630]
is_a: MP:0030516 ! abnormal junctional epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2017-12-22T14:04:20Z" xsd:dateTime

[Term]
id: MP:0030518
name: abnormal outer dental epithelium morphology
def: "any structural anomaly of the layer of cuboidal cells located on the periphery of the enamel organ in a developing tooth; this layer is first seen during the bell stage" [https://en.wikipedia.org/wiki/Outer_enamel_epithelium]
synonym: "abnormal external dental epithelium morphology" EXACT []
synonym: "abnormal external enamel epithelium morphology" EXACT []
synonym: "abnormal outer enamel epithelium morphology" EXACT []
is_a: MP:0030508 ! abnormal dental epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T09:16:03Z" xsd:dateTime

[Term]
id: MP:0030519
name: abnormal inner dental epithelium morphology
def: "any structural anomaly of the inner layer of columnar cells of the enamel organ, located on the rim nearest the dental papilla; this layer is first seen during the cap stage of tooth development, in which inner enamel epithelium cells are pre-ameloblast cells; these will differentiate into ameloblasts which are responsible for secretion of enamel during tooth development" [https://en.wikipedia.org/wiki/Inner_enamel_epithelium]
synonym: "abnormal inner enamel epithelium morphology" EXACT []
synonym: "abnormal internal dental epithelium morphology" EXACT []
synonym: "abnormal internal enamel epithelium morphology" EXACT []
is_a: MP:0030508 ! abnormal dental epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T09:31:07Z" xsd:dateTime

[Term]
id: MP:0030520
name: oral mucosa blisters
def: "localized pockets of fluid that form within or beneath the oral mucosa; may appear as pustules, vesicles, or bullae; color varies according to content of blister, which may include blood, serum, mucin, or suppuration" [https://books.google.com/books?isbn=0470673966, https://medical-dictionary.thefreedictionary.com/blisterform+oral+lesions]
is_a: MP:0003745 ! abnormal oral mucosa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T10:40:18Z" xsd:dateTime

[Term]
id: MP:0030521
name: abnormal cervical loop morphology
def: "any structural anomaly of the most cervical part of an enamel organ where the inner enamel epithelium and the outer enamel epithelium merge in a loop, thus delineating the end of the anatomic crown and the site where root formation begins; to form the root region, the cervical loop begins to grow deeper into the surrounding ectomesenchyme of the dental sac, elongating and moving away from the newly completed crown area to enclose more of the dental papilla, forming Hertwig's epithelial root sheath (HERS)" [https://books.google.com/books?isbn=0323290868, https://books.google.com/books?isbn=1455754099, https://www.stembook.org/node/551]
is_a: MP:0030508 ! abnormal dental epithelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T12:00:30Z" xsd:dateTime

[Term]
id: MP:0030522
name: abnormal stellate reticulum morphology
def: "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
is_a: MP:0030521 ! abnormal cervical loop morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T12:17:21Z" xsd:dateTime

[Term]
id: MP:0030523
name: abnormal stratum intermedium morphology
def: "any structural anomaly of the layer of two or three flattened cells located between the inner enamel epithelium and the newly forming cells of the stellate reticulum; it first appears during the early bell stage of tooth development, has a notably high alkaline phosphatase activity, and forms a part of the dental (enamel) organ; this layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation" [https://en.wikipedia.org/wiki/Stratum_intermedium, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
synonym: "abnormal dental stratum intermedium morphology" EXACT []
synonym: "abnormal tooth stratum intermedium morphology" EXACT []
is_a: MP:0010747 ! abnormal enamel organ morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T12:45:22Z" xsd:dateTime

[Term]
id: MP:0030524
name: abnormal tooth root resorption
def: "pathologic resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms" [MESH:D012391]
synonym: "abnormal dental root resorption" EXACT []
synonym: "root resorption" BROAD []
synonym: "root resorptions" BROAD []
is_a: MP:0031623 ! abnormal tooth physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T13:09:52Z" xsd:dateTime

[Term]
id: MP:0030525
name: abnormal Hertwig epithelial root sheath morphology
def: "any structural anomaly of the bilayered epithelial sheath formed from the fusion of the inner and outer enamel epithelia below the level of the cervical margin of the crown; in mammals, HERS is a transient structure and fragments to form the epithelial cell rests of Malassez; HERS cells appear to be involved in the initiation of the root formation process, in root elongation, and in stimulating both cementogenesis and root dentinogenesis" [https://en.wikipedia.org/wiki/Epithelial_root_sheath, PMID:19576204]
synonym: "abnormal epithelial root sheath morphology" EXACT []
synonym: "abnormal HERS morphology" EXACT []
is_a: MP:0030493 ! abnormal tooth root morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-03T13:45:08Z" xsd:dateTime

[Term]
id: MP:0030526
name: abnormal enamel cord morphology
def: "any structural anomaly of the transient structure of the dental (enamel) organ present at the early cap stage of molar tooth development; the enamel cord is a strand of epithelial cells that runs from (links) the enamel knot to the outer dental epithelial cells, dividing the dental organ into two parts" [https://en.wikipedia.org/wiki/Enamel_cord, ISBN:978-0-12-597951-1]
synonym: "abnormal dental cord morphology" EXACT []
synonym: "abnormal enamel septum morphology" EXACT []
is_a: MP:0010747 ! abnormal enamel organ morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T12:24:39Z" xsd:dateTime

[Term]
id: MP:0030527
name: absent enamel cord
def: "missing the transient structure of the dental (enamel) organ that is normally present at the early cap stage of molar tooth development; the enamel cord is a strand of epithelial cells that runs from (links) the enamel knot to the outer dental epithelial cells, dividing the dental organ into two parts" [https://en.wikipedia.org/wiki/Enamel_cord, https://orcid.org/0000-0002-6490-7723, ISBN:978-0-12-597951-1]
synonym: "absent dental cord" EXACT []
synonym: "absent enamel septum" EXACT []
is_a: MP:0030526 ! abnormal enamel cord morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T12:32:35Z" xsd:dateTime

[Term]
id: MP:0030528
name: abnormal neck skin morphology
def: "any structural anomaly of a zone of skin that is part of the cervical (neck) region" [UBERON:0001417]
is_a: MP:0002060 ! abnormal skin morphology
is_a: MP:0012719 ! abnormal neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T12:42:27Z" xsd:dateTime

[Term]
id: MP:0030529
name: abnormal head skin morphology
def: "any anomaly in a zone of skin that is part of the head" [UBERON:0001084]
is_a: MP:0000432 ! abnormal head morphology
is_a: MP:0002060 ! abnormal skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T13:00:57Z" xsd:dateTime

[Term]
id: MP:0030530
name: abnormal outer ear skin morphology
def: "any anomaly in a zone of skin that is part of an outer ear" [UBERON:0001459]
synonym: "abnormal ear skin morphology" EXACT []
synonym: "abnormal external ear skin morphology" EXACT []
is_a: MP:0002177 ! abnormal outer ear morphology
is_a: MP:0030529 ! abnormal head skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T13:11:53Z" xsd:dateTime

[Term]
id: MP:0030531
name: abnormal facial skin morphology
def: "any anomaly in a zone of skin that is part of the face" [UBERON:1000021]
synonym: "abnormal face skin morphology" EXACT []
is_a: MP:0003743 ! abnormal facial morphology
is_a: MP:0030529 ! abnormal head skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T13:34:51Z" xsd:dateTime

[Term]
id: MP:0030532
name: abnormal periorbital skin morphology
def: "any anomaly in a zone of skin that is part of the periorbital region of the face" [UBERON:0016462]
is_a: MP:0030038 ! abnormal periorbital region morphology
is_a: MP:0030531 ! abnormal facial skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T13:43:17Z" xsd:dateTime

[Term]
id: MP:0030533
name: abnormal snout skin morphology
def: "any anomaly in a zone of skin that is part of the snout" [UBERON:1000015]
is_a: MP:0000443 ! abnormal snout morphology
is_a: MP:0030531 ! abnormal facial skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T13:53:53Z" xsd:dateTime

[Term]
id: MP:0030534
name: abnormal forehead skin morphology
def: "any anomaly in a zone of skin that is part of the forehead" [UBERON:0016475]
is_a: MP:0030031 ! abnormal forehead morphology
is_a: MP:0030531 ! abnormal facial skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-05T14:00:22Z" xsd:dateTime

[Term]
id: MP:0030535
name: abnormal hypoglossal cord morphology
def: "any structural anomaly of the condensed mesenchymal band formed as migratory myoblasts arising from the myotomes of the occipital somites coalesce beside somite four and extend ventrally as an elongated column; the hypoglossal cord eventually becomes located ventral to the caudal region of the pharynx; most of the myoblasts of the hypoglossal cord remain ventral and shift cranially to form the intrinsic and extrinsic tongue muscles; some of these myoblasts shift dorsally to form the intrinsic laryngeal muscles" [https://books.google.com/books?isbn=1455727911]
is_a: MP:0000729 ! abnormal myogenesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T13:34:30Z" xsd:dateTime

[Term]
id: MP:0030536
name: abnormal diastema morphology
def: "any anomaly of the space or gap between two adjacent teeth in the same dental arch; in rodents, the diastema is the toothless (edentulous) region that normally separates a continuously growing single incisor from a segment of three molars in each quadrant of the adult jaw; although tooth primordia develop in the rodent embryonic diastema, they undergo apoptosis and regress to ensure that this region remains tooth-free" [https://en.wikipedia.org/wiki/Diastema, PMID:16890158, PMID:24495023]
synonym: "abnormal dental diastema morphology" EXACT []
synonym: "abnormal interdental space morphology" EXACT []
is_a: MP:0030254 ! abnormal dental arch morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T13:49:09Z" xsd:dateTime

[Term]
id: MP:0030537
name: abnormal notochordal process morphology
def: "any structural anomaly of the midline cellular cord formed from the migration of mesenchymal cells from the primitive knot; the notochordal process is a mesodermal hollow tube structure that grows cranially between the ectoderm and the endoderm until it reaches the prechordal plate" [http://howmed.net/anatomy/embryology/3rd-week-of-development-trilaminar-germ-disc/, https://medical-dictionary.thefreedictionary.com/head+process, UBERON:0006268]
is_a: MP:0012271 ! abnormal chordamesoderm morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T14:11:56Z" xsd:dateTime

[Term]
id: MP:0030538
name: abnormal notochordal plate morphology
def: "any structural anomaly of the dorsal part of the notochordal process when the ventral portion breaks down; it is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube; the folding off of the notochordal plate gives rise to the notochord" [UBERON:0006267]
is_a: MP:0030537 ! abnormal notochordal process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T14:19:48Z" xsd:dateTime

[Term]
id: MP:0030539
name: abnormal head paraxial mesoderm morphology
def: "any structural anomaly of the paraxial mesoderm located on either side of the neural tube, anterior to the occipital somites; in the head region, the unsegmented cranial paraxial mesoderm contributes to the developing heart, specific skull bones and skeletal muscles of the head and neck region" [https://books.google.com/books?isbn=0123849527, https://discovery.lifemapsc.com/in-vivo-development/paraxial-mesoderm, UBERON:0009617]
synonym: "abnormal cephalic paraxial mesenchyme morphology" EXACT []
synonym: "abnormal cephalic paraxial mesoderm morphology" EXACT []
synonym: "abnormal cranial paraxial mesenchyme morphology" EXACT []
synonym: "abnormal cranial paraxial mesoderm morphology" EXACT []
synonym: "abnormal head paraxial mesenchyme morphology" EXACT []
is_a: MP:0008029 ! abnormal paraxial mesoderm morphology
is_a: MP:0011260 ! abnormal head mesenchyme morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T14:26:45Z" xsd:dateTime

[Term]
id: MP:0030540
name: misaligned teeth
def: "abnormal alignment, positioning, or spacing of the teeth" [HP:0000692]
synonym: "abnormal dental position" EXACT []
synonym: "abnormal teeth spacing" EXACT []
synonym: "abnormality of alignment of teeth" EXACT []
synonym: "abnormality of teeth spacing" EXACT []
synonym: "crooked teeth" EXACT []
synonym: "malaligned teeth" EXACT []
synonym: "malposition of teeth" EXACT []
synonym: "malpositioned teeth" EXACT []
synonym: "misalignment of teeth" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T15:05:06Z" xsd:dateTime

[Term]
id: MP:0030541
name: misaligned incisors
def: "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
synonym: "abnormal alignment of incisors" EXACT []
synonym: "crooked incisors" EXACT []
synonym: "incisor misalignment" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0030540 ! misaligned teeth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-12T15:24:26Z" xsd:dateTime

[Term]
id: MP:0030542
name: abnormal dentin development
def: "any anomaly in the process whose specific outcome is the formation of dentin, the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root; dentinogenesis begins prior to enamel formation and is initiated by the odontoblasts of the dental pulp; dentin is derived from the dental papilla of the tooth germ; after apposition of predentin and maturation into dentin, the cell bodies of the odontoblasts remain in the pulp inside the tooth, along its outer wall; unlike enamel, dentin continues to form throughout life and can be initiated in response to stimuli, such as tooth decay or attrition" [GO:0097187, https://en.wikipedia.org/wiki/Dentin]
synonym: "abnormal dentin formation" EXACT []
synonym: "abnormal dentine development" EXACT []
synonym: "abnormal dentine formation" EXACT []
synonym: "abnormal dentinogenesis" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0002818 ! abnormal dentin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T13:47:52Z" xsd:dateTime

[Term]
id: MP:0030543
name: abnormal predentin morphology
def: "any structural anomaly of the initial type I collagen-rich unmineralized extracellular matrix synthesized and secreted by odontoblasts and located at the dentin-pulp interface; predentin is converted to dentin when hydroxyapatite crystals are deposited on the predentin" [https://books.google.com/books?isbn=0470958332]
synonym: "abnormal pre-dentin morphology" EXACT []
synonym: "abnormal pre-dentine morphology" EXACT []
synonym: "abnormal predentine morphology" EXACT []
is_a: MP:0030542 ! abnormal dentin development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T14:15:11Z" xsd:dateTime

[Term]
id: MP:0030544
name: abnormal enamel development
def: "any anomaly in the process whose specific outcome is the formation of dental enamel, the hard outer coating of the exposed portion of the tooth; amelogenesis occurs after the first establishment of dentin, via cells known as ameloblasts, and can generally be divided into two broad stages: (i) a secretory stage that involves proteins and an organic matrix forming a partially mineralized enamel and (ii) a maturation stage which completes enamel mineralization" [GO:0097186, https://en.wikipedia.org/wiki/Tooth_enamel]
synonym: "abnormal amelogenesis" EXACT []
synonym: "abnormal enamel formation" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0002576 ! abnormal enamel morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T14:29:36Z" xsd:dateTime

[Term]
id: MP:0030545
name: abnormal acellular cementum morphology
def: "any structural anomaly of the acellular layer of cementum, a living tissue that does not incorporate cells (cementocytes) into its structure, consisting only of extracellular matrix components and mineral; acellular cementum is the first cementum deposited on the dentin of the forming root, and is predominantly found on the cervical/coronal portion of the tooth root; it anchors the primary collagen fibers of the periodontal ligament, providing a strong attachment between the tooth and surrounding alveolar bone" [http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548]
synonym: "abnormal acellular extrinsic fiber cementum morphology" EXACT []
synonym: "abnormal primary cementum morphology" EXACT []
is_a: MP:0003933 ! abnormal cementum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T14:53:32Z" xsd:dateTime

[Term]
id: MP:0030546
name: abnormal cellular cementum morphology
def: "any structural anomaly of the layer of cementum that contains cementocytes in lacunae; it is most abundant on the apical portion of the tooth root and in the furcation areas of multirooted teeth, and has a role in posteruptive adjustment of tooth position" [http://dental.pitt.edu/periohistology-glossary, http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548]
synonym: "abnormal cellular intrinsic fiber cementum morphology" EXACT []
synonym: "abnormal secondary cementum morphology" EXACT []
is_a: MP:0003933 ! abnormal cementum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T15:02:32Z" xsd:dateTime

[Term]
id: MP:0030547
name: abnormal cementum development
def: "any anomaly in the process whose specific outcome is the formation of dental cementum, a bone-like rigid connective tissue covering the root of a tooth" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cementogenesis" EXACT []
synonym: "abnormal cementum formation" EXACT []
is_a: MP:0000116 ! abnormal tooth development
is_a: MP:0003933 ! abnormal cementum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T15:10:32Z" xsd:dateTime

[Term]
id: MP:0030548
name: abnormal cementoid morphology
def: "any structural anomaly of the organic matrix secreted by cementoblasts, which forms the most recent unmineralized layer covering the surface of cellular cementum" [https://books.google.com/books?isbn=0323058442, https://medicine.academic.ru/110777/cementoid, PMID:27029548]
synonym: "abnormal pre-cementum morphology" EXACT []
synonym: "abnormal uncalcified cementum morphology" EXACT []
is_a: MP:0030547 ! abnormal cementum development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T15:25:54Z" xsd:dateTime

[Term]
id: MP:0030549
name: abnormal cementocyte lacunocanalicular system morphology
def: "any structural anomaly of the osteocyte-like network of lacunae and canaliculi housing the cementocytes and their cytoplasmic processes within the cellular cementum; although cementocytes resemble osteocytes, they show profound differences in terms of dendrite number, lacunar shape, and canalicular network density, suggesting less communication between, to, and from cementocytes compared with osteocytes" [PMID:26274352, PMID:27029548]
synonym: "abnormal cementocyte lacuno-canalicular system morphology" EXACT []
is_a: MP:0030546 ! abnormal cellular cementum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T15:55:54Z" xsd:dateTime

[Term]
id: MP:0030550
name: abnormal cementoblast morphology
def: "any structural anomaly of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig's epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [https://books.google.com/books?isbn=1118342917, PMID:27029548]
is_a: MP:0004986 ! abnormal osteoblast morphology
is_a: MP:0030547 ! abnormal cementum development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T16:05:14Z" xsd:dateTime

[Term]
id: MP:0030551
name: abnormal cementoblast number
def: "deviation from the average number of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig's epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [https://books.google.com/books?isbn=1118342917, PMID:27029548]
is_a: MP:0004987 ! abnormal osteoblast cell number
is_a: MP:0030550 ! abnormal cementoblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T16:17:34Z" xsd:dateTime

[Term]
id: MP:0030552
name: decreased cementoblast number
def: "fewer than the expected number of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig’s epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cementoblast number" EXACT []
is_a: MP:0004989 ! decreased osteoblast cell number
is_a: MP:0030551 ! abnormal cementoblast number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T16:24:36Z" xsd:dateTime

[Term]
id: MP:0030553
name: increased cementoblast number
def: "greater than the expected number of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig’s epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004988 ! increased osteoblast cell number
is_a: MP:0030551 ! abnormal cementoblast number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T16:31:06Z" xsd:dateTime

[Term]
id: MP:0030554
name: abnormal cementocyte morphology
def: "any structural anomaly of an apparently terminally differentiated cementoblast that has become embedded in the cellular cementum in a small cavity called lacuna and that extends long cytoplasmic (dendritic) processes away from the cell body toward other cementocytes and neighboring cells in small channels called canaliculi" [PMID:27029548]
is_a: MP:0008753 ! abnormal osteocyte morphology
is_a: MP:0030549 ! abnormal cementocyte lacunocanalicular system morphology
is_a: MP:0030550 ! abnormal cementoblast morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T16:40:26Z" xsd:dateTime

[Term]
id: MP:0030555
name: abnormal cementocyte lacuna morphology
def: "any structural anomaly of the small cavity within the cellular cementum that is occupied by a cementocyte cell body; cementocyte lacunae are described as larger and more irregular in size and shape (from oval to tubular) and with rougher walls than the typical ellipsoid osteocyte lacunae; occasionally, empty lacunae or lacunae containing more than one cell are observed in cellular cementum, not typically observed in osteocyte lacunae" [PMID:26274352, PMID:27029548]
is_a: MP:0030549 ! abnormal cementocyte lacunocanalicular system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T17:02:33Z" xsd:dateTime

[Term]
id: MP:0030556
name: abnormal cementocyte canaliculus morphology
def: "any structural anomaly of the slender canals situated between lacunae of the cellular cementum where cementocyte cytoplasmic (dendritic) processes reside; cementocyte canaliculi appear to be less organized, more sparse, and do they radiate outward, with the majority of them oriented toward the vascular periodontal ligament for nutrition, unlike osteocyte canaliculi which are radiating, more dense and arranged in a complex network" [https://books.google.com/books?isbn=8131238016, PMID:27029548]
synonym: "abnormal cementocyte canaliculi morphology" EXACT []
is_a: MP:0030549 ! abnormal cementocyte lacunocanalicular system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T17:08:54Z" xsd:dateTime

[Term]
id: MP:0030557
name: abnormal cementocyte dendritic process morphology
def: "any structural anomaly of the long, slender cytoplasmic processes that extend from the cementocyte cell body, run along narrow canaliculi, and are linked to neighboring cementocytes processes via gap junctions; cementocytes harbor fewer dendritic processes than osteocytes" [https://books.google.com/books?isbn=8131238016, PMID:27029548]
synonym: "abnormal cementocyte cytoplasmic process morphology" EXACT []
synonym: "abnormal cementocyte dendrite morphology" EXACT []
synonym: "abnormal cementocyte process morphology" EXACT []
is_a: MP:0030554 ! abnormal cementocyte morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-01-19T17:16:13Z" xsd:dateTime

[Term]
id: MP:0030558
name: absent nasopharynx
def: "failure to form the section of the pharynx that lies above the soft palate" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002251 ! abnormal nasopharynx morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T09:50:22Z" xsd:dateTime

[Term]
id: MP:0030559
name: abnormal dental pulp canal morphology
def: "any structural anomaly of the portion of the dental pulp cavity within the root of a tooth" [https://www.ncbi.nlm.nih.gov/mesh/68003786]
synonym: "abnormal pulp canal morphology" EXACT []
synonym: "abnormal radicular pulp morphology" EXACT [PMID:38105557]
synonym: "abnormal root canal morphology" EXACT []
synonym: "abnormal tooth pulp canal morphology" EXACT []
is_a: MP:0013250 ! abnormal dental pulp morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T10:04:15Z" xsd:dateTime

[Term]
id: MP:0030560
name: enlarged dental pulp canal
def: "increased size of the portion of the dental pulp cavity within the root of a tooth" [https://orcid.org/0000-0002-6490-7723, https://www.ncbi.nlm.nih.gov/mesh/68003786]
synonym: "enlarged dental pulp canals" EXACT []
synonym: "enlarged pulp canals" EXACT []
synonym: "enlarged radicular pulp" EXACT []
synonym: "enlarged root canals" EXACT []
synonym: "enlarged tooth pulp canals" EXACT []
synonym: "increased dental pulp canal size" EXACT []
synonym: "increased radicular pulp size" EXACT []
synonym: "large pulp canals" EXACT []
is_a: MP:0030559 ! abnormal dental pulp canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T10:09:26Z" xsd:dateTime

[Term]
id: MP:0030561
name: abnormal dental pulp chamber morphology
def: "any structural anomaly of the portion of the dental pulp cavity within the crown of a tooth" [https://medical-dictionary.thefreedictionary.com/pulp+chamber, https://www.ncbi.nlm.nih.gov/mesh/68003786]
synonym: "abnormal coronal pulp chamber morphology" EXACT [PMID:38105557]
synonym: "abnormal tooth pulp chamber morphology" EXACT []
is_a: MP:0013250 ! abnormal dental pulp morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T10:27:45Z" xsd:dateTime

[Term]
id: MP:0030562
name: enlarged dental pulp chamber
def: "increased size of the portion of the dental pulp cavity within the crown of a tooth" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged coronal pulp chamber" EXACT []
synonym: "enlarged dental pulp chambers" EXACT []
synonym: "enlarged pulp chambers" EXACT []
synonym: "enlarged tooth pulp chambers" EXACT []
synonym: "increased coronal pulp chamber size" EXACT []
synonym: "increased dental pulp chamber size" EXACT []
synonym: "large pulp chambers" EXACT []
is_a: MP:0030561 ! abnormal dental pulp chamber morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T10:37:10Z" xsd:dateTime

[Term]
id: MP:0030563
name: detached periodontal ligament
def: "partial or complete loss of attachment of the periodontal ligament to the cementum covering the root of a tooth" [https://orcid.org/0000-0002-6490-7723]
synonym: "cementum-PDL detachment" EXACT []
synonym: "detached PDL" EXACT []
synonym: "PDL detachment" EXACT []
synonym: "periodontal ligament detachment" EXACT []
is_a: MP:0003668 ! abnormal periodontal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-02-27T10:54:14Z" xsd:dateTime

[Term]
id: MP:0030564
name: thick myocardium compact layer
def: "increased thickness of the outer, dense layer of the myocardium" [https://orcid.org/0000-0002-6490-7723, PMID:26526197]
synonym: "thick myocardial compact layer" EXACT []
is_a: MP:0004056 ! abnormal myocardium compact layer morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-04-20T10:01:02Z" xsd:dateTime

[Term]
id: MP:0030565
name: decreased circulating ammonia level
def: "reduced concentration of ammonia or its compounds in the blood" [https://orcid.org/0000-0002-6490-7723, PMID:25041126]
synonym: "decreased plasma ammonia level" NARROW []
synonym: "hypoammonaemia" EXACT []
synonym: "hypoammonemia" EXACT []
synonym: "reduced circulating ammonia level" EXACT []
synonym: "reduced plasma ammonia level" NARROW []
is_a: MP:0005308 ! abnormal circulating ammonia level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-04-26T07:52:56Z" xsd:dateTime

[Term]
id: MP:0030566
name: abnormal A band morphology
def: "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band]
synonym: "abnormal A band" BROAD []
synonym: "abnormal A disc" BROAD []
synonym: "abnormal A disk" BROAD []
synonym: "abnormal A-band" BROAD []
synonym: "abnormal A-band morphology" EXACT []
synonym: "abnormal anisotropic band" BROAD []
synonym: "abnormal anisotropic disc" BROAD []
synonym: "abnormal anisotropic disk" BROAD []
synonym: "abnormal Q disc" BROAD []
synonym: "abnormal Q disk" BROAD []
synonym: "abnormal transverse disc" BROAD []
synonym: "abnormal transverse disk" BROAD []
is_a: MP:0004090 ! abnormal sarcomere morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-10T07:16:22Z" xsd:dateTime

[Term]
id: MP:0030567
name: abnormal I band morphology
def: "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
synonym: "abnormal I band" BROAD []
synonym: "abnormal I disc" BROAD []
synonym: "abnormal I disk" BROAD []
synonym: "abnormal I-band morphology" EXACT []
synonym: "abnormal isotropic band" BROAD []
synonym: "abnormal isotropic disc" BROAD []
synonym: "abnormal isotropic disk" BROAD []
synonym: "abnormal J disc" BROAD []
synonym: "abnormal J disk" BROAD []
is_a: MP:0004090 ! abnormal sarcomere morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-10T08:02:41Z" xsd:dateTime

[Term]
id: MP:0030568
name: abnormal H zone morphology
def: "any structural anomaly of the relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; it consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments; within the H zone is a thin dark M line, the attachment site for the thick filaments in the center of the sarcomere" [GO:0031673, https://en.wikipedia.org/wiki/Sarcomere]
synonym: "abnormal H band" BROAD []
synonym: "abnormal H disc" BROAD []
synonym: "abnormal H disk" BROAD []
synonym: "abnormal H zone" BROAD []
synonym: "abnormal H-zone morphology" EXACT []
is_a: MP:0030566 ! abnormal A band morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-10T08:23:49Z" xsd:dateTime

[Term]
id: MP:0030569
name: glomerular capillary endotheliosis
def: "a renal lesion characterized by glomerular endothelial swelling with glomerular hypertrophy, obliteration of endothelial fenestrae, and narrowing or occlusion of the capillary lumens" [PMID:14511965, PMID:17634433]
synonym: "glomerular endotheliosis" BROAD []
is_a: MP:0011453 ! abnormal glomerular capillary endothelium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-11T11:31:29Z" xsd:dateTime

[Term]
id: MP:0030570
name: abnormal piliary canal morphology
def: "any structural anomaly of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft" [PMID:19211055, UBERON:0035610]
synonym: "abnormal hair canal morphology" EXACT [PMID:20882038]
synonym: "abnormal pilary canal morphology" EXACT [PMID:20882038, PMID:29056331]
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-11T12:07:44Z" xsd:dateTime

[Term]
id: MP:0030571
name: dilated piliary canal
def: "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [https://orcid.org/0000-0002-6490-7723, PMID:11171393]
synonym: "dilated hair canal" EXACT []
synonym: "dilated hair canals" EXACT []
synonym: "dilated pilary canal" EXACT []
synonym: "dilated pilary canals" EXACT []
synonym: "dilated piliary canals" EXACT []
synonym: "hair canal dilation" EXACT []
synonym: "pilary canal dilation" EXACT []
synonym: "piliary canal dilation" EXACT []
is_a: MP:0030570 ! abnormal piliary canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-11T12:21:16Z" xsd:dateTime

[Term]
id: MP:0030572
name: abnormal pilosebaceous unit morphology
def: "any structural anomaly of an epidermal invagination consisting of hair, hair follicle, arrector pili muscle and sebaceous gland" [https://en.wiktionary.org/wiki/pilosebaceous_unit, UBERON:0011932]
synonym: "abnormal fabrica pilosebacea morphology" EXACT []
synonym: "abnormal pilo-sebaceous apparatus morphology" EXACT []
synonym: "abnormal pilo-sebaceous unit morphology" EXACT []
synonym: "abnormal pilosebaceous apparatus morphology" EXACT []
is_a: MP:0010678 ! abnormal skin adnexa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-16T11:07:16Z" xsd:dateTime

[Term]
id: MP:0030573
name: abnormal hair follicle cell proliferation
def: "anomaly in the ability of any hair follicle cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011194 ! abnormal hair follicle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-16T12:29:40Z" xsd:dateTime

[Term]
id: MP:0030574
name: increased hair follicle cell proliferation
def: "increase in the expansion rate of a hair follicle cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030573 ! abnormal hair follicle cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-16T13:04:57Z" xsd:dateTime

[Term]
id: MP:0030575
name: decreased hair follicle cell proliferation
def: "reduction in the expansion rate of a hair follicle cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced hair follicle cell proliferation" EXACT []
is_a: MP:0030573 ! abnormal hair follicle cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-16T13:07:09Z" xsd:dateTime

[Term]
id: MP:0030576
name: abnormal keratinocyte adhesion
def: "any anomaly in the adhesive properties of keratinocytes, resulting in abnormal cell to cell and cell to extracellular matrix (ECM) interactions" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003453 ! abnormal keratinocyte physiology
is_a: MP:0003566 ! abnormal cell adhesion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T11:17:42Z" xsd:dateTime

[Term]
id: MP:0030577
name: increased keratinocyte adhesion
def: "increased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030576 ! abnormal keratinocyte adhesion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T11:22:31Z" xsd:dateTime

[Term]
id: MP:0030578
name: decreased keratinocyte adhesion
def: "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced keratinocyte adhesion" EXACT []
is_a: MP:0030576 ! abnormal keratinocyte adhesion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T11:30:51Z" xsd:dateTime

[Term]
id: MP:0030579
name: thoracoabdominoschisis
def: "a congenital fissure of both the thoracic and abdominal walls" [https://www.ncbi.nlm.nih.gov/medgen/672583]
synonym: "thoraco-abdominoschisis" EXACT []
synonym: "thoraco-gastroschisis" EXACT []
synonym: "thoracoabdominal schisis" EXACT []
synonym: "thoracoceloschisis" EXACT []
synonym: "thoracocoeloschisis" EXACT []
synonym: "thoracogastroschisis" EXACT []
is_a: MP:0003257 ! abnormal abdominal wall morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T11:42:22Z" xsd:dateTime

[Term]
id: MP:0030580
name: abnormal hair follicle placode morphology
def: "any structural anomaly of any of the local epithelial thickenings in the embryonic epidermis that define the location of the hair follicles; in mouse, embryonic hair follicle development is initiated by the first dermal signal, originating from dermal fibroblasts, leading to the formation of placodes at ~E13.5; each placode sends a message back to underlying dermis, which results in the formation of an aggregate of mesenchymal cells known as the dermal condensate; the placodes then grow downward, giving rise to the hair germ by E15.5, the hair peg by E17.5, and the bulbous hair peg by E18.5" [https://discovery.lifemapsc.com/in-vivo-development/hair/hair-follicle, UBERON:0005086]
synonym: "abnormal hair placode morphology" EXACT []
is_a: MP:0003704 ! abnormal hair follicle development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T11:56:31Z" xsd:dateTime

[Term]
id: MP:0030581
name: absent hair follicle placode
def: "absence of the local epithelial thickening in the embryonic epidermis that normally gives rise to the hair follicle bud (aka hair germ)" [GO:0060789, https://orcid.org/0000-0002-6490-7723]
synonym: "absent hair placode" EXACT []
is_a: MP:0030580 ! abnormal hair follicle placode morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T12:03:03Z" xsd:dateTime

[Term]
id: MP:0030582
name: abnormal hair follicle placode formation
def: "any anomaly in the developmental process in which a hair placode forms; in mouse, hair placode formation is initiated at ~E13.5 in response to the first dermal signal originating from dermal fibroblasts; the resulting primary hair placode cells signal to the underlying dermis, triggering formation of dermal condensates that will coordinate further differentiation of hair-forming cells; hair placode formation progresses through 3 successive waves (1) primary hair placodes form at E14.5 and produce guard hair, (2) secondary hair placodes form at E16-17 and produce awl hair, and (3) the third wave of hair follicle induction produces tertiary placodes and generate zig-zag hair" [GO:0060789, https://discovery.lifemapsc.com/in-vivo-development/hair/hair-follicle/primary-hair-placode-cells]
synonym: "abnormal hair placode formation" EXACT []
is_a: MP:0030580 ! abnormal hair follicle placode morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T12:49:51Z" xsd:dateTime

[Term]
id: MP:0030583
name: abnormal hair follicle peg morphology
def: "any structural anomaly of the solid column of keratinocytes growing into the dermis during embryonic hair follicle development; the concave proximal end starts to encase the dermal condensate, the future dermal papilla" [UBERON:0035611]
synonym: "abnormal hair peg morphology" EXACT []
is_a: MP:0003704 ! abnormal hair follicle development
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-18T13:06:41Z" xsd:dateTime

[Term]
id: MP:0030584
name: skin atrophy
def: "acquired diminution of skin tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic skin" EXACT []
is_a: MP:0002060 ! abnormal skin morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T07:37:19Z" xsd:dateTime

[Term]
id: MP:0030585
name: enhanced behavioral response to amphetamine
def: "increased sensitivity to amphetamine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced behavioural response to amphetamine" EXACT []
is_a: MP:0013894 ! abnormal behavioral response to amphetamine
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T07:56:25Z" xsd:dateTime

[Term]
id: MP:0030586
name: impaired behavioral response to amphetamine
def: "decreased sensitivity to amphetamine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired behavioural response to amphetamine" EXACT []
is_a: MP:0013894 ! abnormal behavioral response to amphetamine
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T08:00:33Z" xsd:dateTime

[Term]
id: MP:0030587
name: abnormal pancreatic alpha cell mass
def: "anomaly in the total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glucagon-secreting cell mass" EXACT []
synonym: "abnormal pancreatic A cell mass" EXACT []
is_a: MP:0005216 ! abnormal pancreatic alpha cell morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T08:18:35Z" xsd:dateTime

[Term]
id: MP:0030588
name: decreased pancreatic alpha cell mass
def: "reduced total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased glucagon-secreting cell mass" EXACT []
synonym: "decreased pancreatic A cell mass" EXACT []
synonym: "reduced glucagon-secreting cell mass" EXACT []
synonym: "reduced pancreatic A cell mass" EXACT []
synonym: "reduced pancreatic alpha cell mass" EXACT []
is_a: MP:0030587 ! abnormal pancreatic alpha cell mass
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T08:33:06Z" xsd:dateTime

[Term]
id: MP:0030589
name: increased pancreatic alpha cell mass
def: "greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased glucagon-secreting cell mass" EXACT []
synonym: "increased pancreatic A cell mass" EXACT []
is_a: MP:0030587 ! abnormal pancreatic alpha cell mass
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T08:44:19Z" xsd:dateTime

[Term]
id: MP:0030590
name: abnormal sperm fibrous sheath morphology
def: "any structural anomaly of the unique cytoskeletal component in the principal-piece segment of the sperm flagellum which surrounds the axoneme and outer dense fibers and contains two longitudinal columns that are connected by closely organized semicircular transverse ribs; the fibrous sheath is believed to regulate the degree of flexibility, flagellar motion and shape of the flagellar beat during the lifespan of a sperm cell" [GO:0035686, PMID:27802166, PMID:3282552]
synonym: "abnormal fibrous sheath of sperm principal piece morphology" EXACT []
synonym: "abnormal sperm flagellar fibrous sheath morphology" EXACT []
synonym: "abnormal sperm flagellum fibrous sheath morphology" EXACT []
synonym: "abnormal sperm principal piece fibrous sheath morphology" EXACT []
synonym: "abnormal sperm tail fibrous sheath morphology" EXACT []
is_a: MP:0009836 ! abnormal sperm principal piece morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T09:13:36Z" xsd:dateTime

[Term]
id: MP:0030591
name: absent sperm fibrous sheath
def: "missing the unique cytoskeletal component of the principal-piece segment of the sperm flagellum which surrounds the axoneme and outer dense fibers and contains two longitudinal columns that are connected by closely organized semicircular transverse ribs" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent fibrous sheath of sperm principal piece" EXACT []
synonym: "absent sperm flagellar fibrous sheath" EXACT []
synonym: "absent sperm flagellum fibrous sheath" EXACT []
synonym: "absent sperm principal piece fibrous sheath" EXACT []
synonym: "absent sperm tail fibrous sheath" EXACT []
is_a: MP:0030590 ! abnormal sperm fibrous sheath morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-05-29T09:43:09Z" xsd:dateTime

[Term]
id: MP:0030592
name: abnormal manganese homeostasis
def: "anomaly in the processes involved in the maintenance of an internal steady state of manganese ions within an organism or cell; manganese ions function as cofactors for a large variety of enzymes with many functions; while the element is a required trace mineral for all known living organisms, it also acts as a neurotoxin in larger amounts" [GO:0055071, https://en.wikipedia.org/wiki/Manganese]
synonym: "abnormal manganese ion homeostasis" EXACT []
is_a: MP:0001765 ! abnormal ion homeostasis
is_a: MP:0005636 ! abnormal mineral homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:03:47Z" xsd:dateTime

[Term]
id: MP:0030593
name: abnormal manganese level
def: "any anomaly in the concentration of manganese in the body" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000192 ! abnormal mineral level
is_a: MP:0030592 ! abnormal manganese homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:15:40Z" xsd:dateTime

[Term]
id: MP:0030594
name: abnormal brain manganese level
def: "any anomaly in the amount of manganese present in brain tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0030593 ! abnormal manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:19:31Z" xsd:dateTime

[Term]
id: MP:0030595
name: increased brain manganese level
def: "a greater accumulation of manganese in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014543 ! increased manganese level
is_a: MP:0030594 ! abnormal brain manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:25:03Z" xsd:dateTime

[Term]
id: MP:0030596
name: decreased brain manganese level
def: "a reduced amount of manganese in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain manganese level" EXACT []
is_a: MP:0014544 ! decreased manganese level
is_a: MP:0030594 ! abnormal brain manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:28:20Z" xsd:dateTime

[Term]
id: MP:0030597
name: abnormal liver manganese level
def: "any anomaly in the amount of manganese present in liver tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hepatic manganese content" EXACT []
synonym: "abnormal liver manganese concentration" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0030593 ! abnormal manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:32:47Z" xsd:dateTime

[Term]
id: MP:0030598
name: increased liver manganese level
def: "a greater accumulation of manganese in liver tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased hepatic manganese level" EXACT []
synonym: "increased liver manganese concentration" EXACT []
is_a: MP:0014543 ! increased manganese level
is_a: MP:0030597 ! abnormal liver manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:38:07Z" xsd:dateTime

[Term]
id: MP:0030599
name: decreased liver manganese level
def: "a reduced amount of manganese in liver tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased hepatic manganese level" EXACT []
synonym: "decreased liver manganese concentration" EXACT []
synonym: "reduced hepatic manganese level" EXACT []
synonym: "reduced liver manganese concentration" EXACT []
synonym: "reduced liver manganese level" EXACT []
is_a: MP:0014544 ! decreased manganese level
is_a: MP:0030597 ! abnormal liver manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:42:09Z" xsd:dateTime

[Term]
id: MP:0030600
name: abnormal circulating manganese level
def: "any anomaly in the blood concentration of manganese" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006357 ! abnormal circulating mineral level
is_a: MP:0030593 ! abnormal manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:46:37Z" xsd:dateTime

[Term]
id: MP:0030601
name: increased circulating manganese level
def: "greater than normal concentration of manganese in the blood" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014543 ! increased manganese level
is_a: MP:0014547 ! increased circulating mineral level
is_a: MP:0030600 ! abnormal circulating manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:50:19Z" xsd:dateTime

[Term]
id: MP:0030602
name: decreased circulating manganese level
def: "less than the normal concentration of manganese in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced circulating manganese level" EXACT []
is_a: MP:0014544 ! decreased manganese level
is_a: MP:0014548 ! decreased circulating mineral level
is_a: MP:0030600 ! abnormal circulating manganese level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T07:52:17Z" xsd:dateTime

[Term]
id: MP:0030603
name: increased sperm number
def: "increased concentration of spermatozoa in the seminal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased sperm count" EXACT []
is_a: MP:0002673 ! abnormal sperm number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-04T09:22:35Z" xsd:dateTime

[Term]
id: MP:0030604
name: abnormal ammonia homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of ammonia in the fluids and tissues" [GO:0097272, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-08T07:10:57Z" xsd:dateTime

[Term]
id: MP:0030605
name: abnormal corneocyte morphology
def: "any structural anomaly of the de-nucleated, dead keratin-filled squamous cell of the stratum corneum; a corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis" [CL:0002153, GO:0003335]
is_a: MP:0001240 ! abnormal epidermis stratum corneum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-06-08T07:43:19Z" xsd:dateTime

[Term]
id: MP:0030606
name: abnormal gingival sulcus moprhology
def: "any anomaly in the area of potential space between a tooth and the surrounding gingival tissue that is lined by sulcular epithelium; the depth of the sulcus is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin" [https://en.wikipedia.org/wiki/Gingival_sulcus, UBERON:0008805]
synonym: "abnormal gingival crevice moprhology" EXACT []
synonym: "abnormal gingival groove moprhology" EXACT []
synonym: "abnormal tooth-gingiva interface moprhology" EXACT []
is_a: MP:0013818 ! abnormal oral cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-02T10:26:20Z" xsd:dateTime

[Term]
id: MP:0030607
name: abnormal sex cord morphology
def: "any structural anomaly of the cord-like masses of epithelial tissue that invaginate from the germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female" [UBERON:0005295]
synonym: "abnormal genital cord morphology" EXACT []
synonym: "abnormal gonad cord morphology" EXACT []
synonym: "abnormal gonadal cord morphology" EXACT []
synonym: "abnormal primitive sex cord morphology" EXACT []
is_a: MP:0011411 ! abnormal gonadal ridge morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-02T10:39:36Z" xsd:dateTime

[Term]
id: MP:0030608
name: decreased tooth number
def: "reduction in the number of the bony structures of the upper and lower jaws used in mastication" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypodontia" NARROW []
synonym: "missing teeth" EXACT []
synonym: "oligodontia" NARROW []
synonym: "reduced number of teeth" EXACT []
synonym: "reduced tooth number" EXACT []
is_a: MP:0030611 ! abnormal tooth number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-12T15:13:04Z" xsd:dateTime

[Term]
id: MP:0030609
name: decreased incisor number
def: "reduction in the number of the long teeth, normally consisting of two pairs, top and bottom, that are the most anterior and prominent in the jaw" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced incisor number" EXACT []
synonym: "reduced number of incisors" EXACT []
is_a: MP:0005358 ! abnormal incisor morphology
is_a: MP:0030608 ! decreased tooth number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-12T15:20:10Z" xsd:dateTime

[Term]
id: MP:0030610
name: absent teeth
def: "absence of all of the bony structures of the upper and lower jaws used in mastication" [https://orcid.org/0000-0002-6490-7723]
synonym: "anodontia" EXACT []
synonym: "complete dental agenesis" EXACT []
synonym: "complete tooth agenesis" EXACT []
synonym: "edentulous" EXACT []
synonym: "tooth aplasia" EXACT []
synonym: "toothless" EXACT []
is_a: MP:0030608 ! decreased tooth number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-12T15:24:32Z" xsd:dateTime

[Term]
id: MP:0030611
name: abnormal tooth number
def: "anomaly in the number of the bony structures of the upper and lower jaws used in mastication" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal number of teeth" EXACT []
synonym: "abnormal tooth count" EXACT []
is_a: MP:0002100 ! abnormal tooth morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-07-13T16:57:34Z" xsd:dateTime

[Term]
id: MP:0030612
name: organic aciduria
def: "increased excretion of non-amino organic acids in urine" [HP:0001992]
is_a: MP:0010028 ! aciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T09:12:30Z" xsd:dateTime

[Term]
id: MP:0030613
name: dicarboxylic aciduria
def: "an increased concentration of dicarboxylic acid in the urine, occurring during increased mobilization or inhibited beta-oxidation of fatty acids, where a number of 3-hydroxydicarboxylic acids are excreted in urine" [HP:0003215]
is_a: MP:0030612 ! organic aciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T09:19:39Z" xsd:dateTime

[Term]
id: MP:0030614
name: methylmalonic aciduria
def: "increased concentration of methylmalonic acid in the urine" [HP:0012120]
is_a: MP:0030613 ! dicarboxylic aciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T10:50:35Z" xsd:dateTime

[Term]
id: MP:0030615
name: ethylmalonic aciduria
def: "increased concentration of ethylmalonic acid in the urine; ethylmalonic acid is a dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group" [HP:0003219]
is_a: MP:0030613 ! dicarboxylic aciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T10:57:12Z" xsd:dateTime

[Term]
id: MP:0030616
name: hyperglycinuria
def: "excretion of excessive amounts of glycine in the urine" [HP:0003108]
synonym: "glycinuria" EXACT []
synonym: "increased urine glycine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030658 ! increased glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T11:15:29Z" xsd:dateTime

[Term]
id: MP:0030617
name: hyperglutaminuria
def: "excretion of excessive amounts of glutamine in the urine" [HP:0025376, https://orcid.org/0000-0002-6490-7723]
synonym: "glutaminuria" EXACT []
synonym: "increased urine glutamine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030706 ! increased glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T11:24:13Z" xsd:dateTime

[Term]
id: MP:0030618
name: tryptophanuria
def: "excretion of excessive amounts of tryptophan in the urine" [HP:0003361, https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine tryptophan level" EXACT []
is_a: MP:0003311 ! aminoaciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T11:29:19Z" xsd:dateTime

[Term]
id: MP:0030619
name: homogentisic aciduria
def: "excretion of excessive amounts of homogentisic acid (an intermediate in the tyrosine degradation pathway) and its oxidized form (benzoquinoneacetate) in the urine, giving it an unusually dark color on prolonged exposure to air" [PMID:25003018]
comment: Homogentisic aciduria is one of the three distinct clinical features of alkaptonuria (AKU), along with ochronosis and ochronotic osteoarthropathy; the darkening of urine occurs because the HGA pigment oxidizes to benzoquinoneacetate (BQA), which forms a melanin-like polymer that slowly turns urine black {xref="PMID:8188247", xref="PMID:25003018"}
synonym: "increased urine homogentisic acid level" EXACT []
is_a: MP:0010028 ! aciduria
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-24T11:55:51Z" xsd:dateTime

[Term]
id: MP:0030620
name: valinuria
def: "excretion of excessive amounts of valine in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypervalinuria" EXACT []
synonym: "increased urine valine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030724 ! increased valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T06:19:58Z" xsd:dateTime

[Term]
id: MP:0030621
name: abnormal cysteine level
def: "anomaly in the amount of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3; the thiol side chain in cysteine is susceptible to oxidation to give the disulfide derivative cystine, which serves an important structural role in many proteins" [CHEBI:15356]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:00:34Z" xsd:dateTime

[Term]
id: MP:0030622
name: increased cysteine level
def: "increase in the amount of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3" [CHEBI:15356, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030621 ! abnormal cysteine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:16:55Z" xsd:dateTime

[Term]
id: MP:0030623
name: decreased cysteine level
def: "reduction in the amount of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3" [CHEBI:15356, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cysteine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030621 ! abnormal cysteine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:24:15Z" xsd:dateTime

[Term]
id: MP:0030624
name: abnormal circulating cysteine level
def: "anomaly in the amount per unit of blood of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3" [CHEBI:15356, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030621 ! abnormal cysteine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:28:16Z" xsd:dateTime

[Term]
id: MP:0030625
name: increased circulating cysteine level
def: "increase in the amount per unit of blood of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3" [CHEBI:15356, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030622 ! increased cysteine level
is_a: MP:0030624 ! abnormal circulating cysteine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:46:47Z" xsd:dateTime

[Term]
id: MP:0030626
name: decreased circulating cysteine level
def: "reduction in the amount per unit of blood of cysteine, a sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3" [CHEBI:15356, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced circulating cysteine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030623 ! decreased cysteine level
is_a: MP:0030624 ! abnormal circulating cysteine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T07:50:36Z" xsd:dateTime

[Term]
id: MP:0030627
name: abnormal methylmalonic acid level
def: "any anomaly in the amount of methylmalonic acid, a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group" [CHEBI:30860]
is_a: MP:0004019 ! abnormal vitamin homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:04:58Z" xsd:dateTime

[Term]
id: MP:0030628
name: increased methylmalonic acid level
def: "increase in the amount of methylmalonic acid, a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group" [CHEBI:30860, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030627 ! abnormal methylmalonic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:11:19Z" xsd:dateTime

[Term]
id: MP:0030629
name: decreased methylmalonic acid level
def: "reduction in the amount of methylmalonic acid, a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group" [CHEBI:30860, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced methylmalonic acid level" EXACT []
is_a: MP:0030627 ! abnormal methylmalonic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:15:36Z" xsd:dateTime

[Term]
id: MP:0030630
name: increased circulating methylmalonic acid level
def: "increased concentration in the blood of methylmalonic acid, a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group" [CHEBI:30860, HP:0002912]
synonym: "methylmalonic acidaemia" EXACT []
synonym: "methylmalonic acidemia" EXACT []
is_a: MP:0030628 ! increased methylmalonic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:18:39Z" xsd:dateTime

[Term]
id: MP:0030631
name: abnormal urine creatine level
def: "any change in the amount of creatine in the urine; creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen" [CHEBI:16919, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0010060 ! abnormal creatine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:34:38Z" xsd:dateTime

[Term]
id: MP:0030632
name: increased urine creatine level
def: "an increased concentration of creatine in the urine; creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen" [CHEBI:16919, https://orcid.org/0000-0002-6490-7723]
synonym: "creatinuria" EXACT []
is_a: MP:0010061 ! increased creatine level
is_a: MP:0030631 ! abnormal urine creatine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:37:34Z" xsd:dateTime

[Term]
id: MP:0030633
name: decreased urine creatine level
def: "a decreased concentration of creatine in the urine; creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen" [CHEBI:16919, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urine creatine level" EXACT []
is_a: MP:0010062 ! decreased creatine level
is_a: MP:0030631 ! abnormal urine creatine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T08:50:03Z" xsd:dateTime

[Term]
id: MP:0030634
name: abnormal taurine level
def: "anomaly in the amount of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine metabolism" [CHEBI:15891]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:02:13Z" xsd:dateTime

[Term]
id: MP:0030635
name: increased taurine level
def: "increase in the amount of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine metabolism" [CHEBI:15891, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030634 ! abnormal taurine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:08:43Z" xsd:dateTime

[Term]
id: MP:0030636
name: decreased taurine level
def: "reduction in the amount of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine metabolism" [CHEBI:15891, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced taurine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030634 ! abnormal taurine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:11:39Z" xsd:dateTime

[Term]
id: MP:0030637
name: abnormal circulating taurine level
def: "anomaly in the amount per unit of blood of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine" [CHEBI:15891, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030634 ! abnormal taurine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:14:36Z" xsd:dateTime

[Term]
id: MP:0030638
name: increased circulating taurine level
def: "increase in the amount per unit of blood of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine" [CHEBI:15891, https://orcid.org/0000-0002-6490-7723]
synonym: "taurinemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030635 ! increased taurine level
is_a: MP:0030637 ! abnormal circulating taurine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:21:11Z" xsd:dateTime

[Term]
id: MP:0030639
name: decreased circulating taurine level
def: "reduction in the amount per unit of blood of taurine, an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid; taurine is a naturally occurring amino acid derived from methionine and cysteine" [CHEBI:15891, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced circulating taurine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030636 ! decreased taurine level
is_a: MP:0030637 ! abnormal circulating taurine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-29T09:35:45Z" xsd:dateTime

[Term]
id: MP:0030640
name: abnormal methionine level
def: "anomaly in the amount of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins; methionine is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4" [CHEBI:16811, GO:0006555]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T08:34:12Z" xsd:dateTime

[Term]
id: MP:0030641
name: increased methionine level
def: "increase in the amount of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins" [GO:0006555, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030640 ! abnormal methionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T08:41:20Z" xsd:dateTime

[Term]
id: MP:0030642
name: decreased methionine level
def: "reduction in the amount of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins" [GO:0006555, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced methionine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030640 ! abnormal methionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T08:44:49Z" xsd:dateTime

[Term]
id: MP:0030643
name: abnormal circulating methionine level
def: "anomaly in the amount per unit of blood of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins" [GO:0006555, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma methionine level" NARROW []
synonym: "abnormal serum methionine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030640 ! abnormal methionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T08:48:42Z" xsd:dateTime

[Term]
id: MP:0030644
name: increased circulating methionine level
def: "increase in the amount per unit of blood of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins" [GO:0006555, https://orcid.org/0000-0002-6490-7723]
synonym: "hypermethioninaemia" EXACT []
synonym: "hypermethioninemia" EXACT [HP:0003235]
synonym: "increased plasma methionine level" NARROW []
synonym: "increased serum methionine level" NARROW []
synonym: "methioninaemia" EXACT []
synonym: "methioninemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030641 ! increased methionine level
is_a: MP:0030643 ! abnormal circulating methionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T08:56:27Z" xsd:dateTime

[Term]
id: MP:0030645
name: decreased circulating methionine level
def: "reduction in the amount per unit of blood of methionine, a sulfur-containing, essential amino acid found in peptide linkage in proteins" [GO:0006555, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma methionine level" NARROW []
synonym: "decreased serum methionine level" NARROW []
synonym: "hypomethioninaemia" EXACT []
synonym: "hypomethioninemia" EXACT [HP:0003658]
synonym: "reduced circulating methionine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030642 ! decreased methionine level
is_a: MP:0030643 ! abnormal circulating methionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:05:00Z" xsd:dateTime

[Term]
id: MP:0030646
name: abnormal ornithine level
def: "anomaly in the amount of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis; ornithine is an alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5" [CHEBI:18257, GO:0006591]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:45:24Z" xsd:dateTime

[Term]
id: MP:0030647
name: increased ornithine level
def: "increase in the amount of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis" [GO:0006591, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030646 ! abnormal ornithine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:49:01Z" xsd:dateTime

[Term]
id: MP:0030648
name: decreased ornithine level
def: "reduction in the amount of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis" [GO:0006591, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced ornithine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030646 ! abnormal ornithine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:51:52Z" xsd:dateTime

[Term]
id: MP:0030649
name: abnormal circulating ornithine level
def: "anomaly in the amount per unit of blood of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis" [GO:0006591, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma ornithine level" NARROW []
synonym: "abnormal serum ornithine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030646 ! abnormal ornithine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:54:40Z" xsd:dateTime

[Term]
id: MP:0030650
name: increased circulating ornithine level
def: "increase in the amount per unit of blood of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis" [GO:0006591, https://orcid.org/0000-0002-6490-7723]
synonym: "hyperornithinaemia" EXACT []
synonym: "hyperornithinemia" EXACT [HP:0012026]
synonym: "increased plasma ornithine level" NARROW []
synonym: "increased serum ornithine level" NARROW []
synonym: "ornithinaemia" EXACT []
synonym: "ornithinemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030647 ! increased ornithine level
is_a: MP:0030649 ! abnormal circulating ornithine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T09:58:54Z" xsd:dateTime

[Term]
id: MP:0030651
name: decreased circulating ornithine level
def: "reduction in the amount per unit of blood of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis" [GO:0006591, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma ornithine level" NARROW []
synonym: "decreased serum ornithine level" NARROW []
synonym: "hypoornithinaemia" EXACT []
synonym: "hypoornithinemia" EXACT []
synonym: "reduced circulating ornithine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030648 ! decreased ornithine level
is_a: MP:0030649 ! abnormal circulating ornithine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:03:39Z" xsd:dateTime

[Term]
id: MP:0030652
name: abnormal circulating glutathione level
def: "aberrant concentration in the blood of glutathione, a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal circulating GSH level" EXACT []
synonym: "abnormal plasma glutathione level" NARROW []
synonym: "abnormal plasma GSH level" NARROW []
synonym: "abnormal serum glutathione level" NARROW []
synonym: "abnormal serum GSH level" NARROW []
is_a: MP:0012603 ! abnormal glutathione level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:23:38Z" xsd:dateTime

[Term]
id: MP:0030653
name: increased circulating glutathione level
def: "increase in the amount per unit of blood of glutathione, a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine" [CHEBI:16856, https://orcid.org/0000-0002-6490-7723]
synonym: "glutathionaemia" EXACT []
synonym: "glutathionemia" EXACT []
synonym: "increased circulating GSH level" EXACT []
synonym: "increased plasma glutathione level" NARROW []
synonym: "increased plasma GSH level" NARROW []
synonym: "increased serum glutathione level" NARROW []
synonym: "increased serum GSH level" NARROW []
is_a: MP:0012606 ! increased glutathione level
is_a: MP:0030652 ! abnormal circulating glutathione level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:30:31Z" xsd:dateTime

[Term]
id: MP:0030654
name: abnormal circulating glycine level
def: "aberrant concentration in the blood of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain" [CHEBI:15428, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma glycine level" NARROW []
synonym: "abnormal serum glycine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030657 ! abnormal glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:37:59Z" xsd:dateTime

[Term]
id: MP:0030655
name: increased circulating glycine level
def: "increase in the amount per unit of blood of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain" [CHEBI:15428, https://orcid.org/0000-0002-6490-7723]
synonym: "glycinaemia" EXACT []
synonym: "glycinemia" EXACT []
synonym: "hyperglycinaemia" EXACT [HP:0002154]
synonym: "hyperglycinemia" EXACT [HP:0002154]
synonym: "increased plasma glycine level" NARROW []
synonym: "increased serum glycine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030654 ! abnormal circulating glycine level
is_a: MP:0030658 ! increased glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:44:35Z" xsd:dateTime

[Term]
id: MP:0030656
name: decreased circulating glycine level
def: "reduction in the amount per unit of blood of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain" [CHEBI:15428, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma glycine level" NARROW []
synonym: "decreased serum glycine level" NARROW []
synonym: "hypoglycinaemia" EXACT []
synonym: "hypoglycinemia" EXACT [HP:0012277]
synonym: "reduced circulating glycine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030654 ! abnormal circulating glycine level
is_a: MP:0030659 ! decreased glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T10:54:37Z" xsd:dateTime

[Term]
id: MP:0030657
name: abnormal glycine level
def: "anomaly in the amount of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain; glycine is a major inhibitory neurotransmitter in the mammalian central nervous system" [CHEBI:15428, https://en.wikipedia.org/wiki/Glycine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:01:23Z" xsd:dateTime

[Term]
id: MP:0030658
name: increased glycine level
def: "increase in the amount of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain" [CHEBI:15428, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030657 ! abnormal glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:07:51Z" xsd:dateTime

[Term]
id: MP:0030659
name: decreased glycine level
def: "reduction in the amount of glycine, the simplest (and the only achiral) proteinogenic amino acid that has a single hydrogen atom as its side chain" [CHEBI:15428, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced glycine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030657 ! abnormal glycine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:12:08Z" xsd:dateTime

[Term]
id: MP:0030660
name: abnormal circulating arginine level
def: "aberrant concentration in the blood of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma arginine level" NARROW []
synonym: "abnormal serum arginine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030663 ! abnormal arginine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:22:21Z" xsd:dateTime

[Term]
id: MP:0030661
name: increased circulating arginine level
def: "increase in the amount per unit of blood of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group; usually associated with a deficiency of arginase" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
synonym: "argininaemia" EXACT []
synonym: "argininemia" EXACT []
synonym: "hyperargininaemia" EXACT []
synonym: "hyperargininemia" EXACT []
synonym: "increased plasma arginine level" NARROW []
synonym: "increased serum arginine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030660 ! abnormal circulating arginine level
is_a: MP:0030664 ! increased arginine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:26:22Z" xsd:dateTime

[Term]
id: MP:0030662
name: decreased circulating arginine level
def: "reduction in the amount per unit of blood of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma arginine level" NARROW []
synonym: "decreased serum arginine level" NARROW []
synonym: "hypoargininaemia" EXACT []
synonym: "hypoargininemia" EXACT [HP:0005961]
synonym: "reduced circulating arginine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030660 ! abnormal circulating arginine level
is_a: MP:0030665 ! decreased arginine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:31:13Z" xsd:dateTime

[Term]
id: MP:0030663
name: abnormal arginine level
def: "anomaly in the amount of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:36:44Z" xsd:dateTime

[Term]
id: MP:0030664
name: increased arginine level
def: "increase in the amount of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030663 ! abnormal arginine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:40:58Z" xsd:dateTime

[Term]
id: MP:0030665
name: decreased arginine level
def: "reduction in the amount of arginine, an alpha-amino acid that is glycine in which the alpha- is substituted by a 3-guanidinopropyl group" [CHEBI:29016, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced arginine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030663 ! abnormal arginine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:45:30Z" xsd:dateTime

[Term]
id: MP:0030666
name: abnormal circulating proline level
def: "aberrant concentration in the blood of proline, an alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2; proline is a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins" [CHEBI:26271, GO:0006560, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma proline level" NARROW []
synonym: "abnormal serum proline level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0020236 ! abnormal proline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T11:57:27Z" xsd:dateTime

[Term]
id: MP:0030667
name: increased circulating proline level
def: "increase in the amount per unit of blood of proline, an alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2; proline is a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins" [CHEBI:26271, GO:0006560, https://orcid.org/0000-0002-6490-7723]
synonym: "hyperprolinaemia" EXACT []
synonym: "hyperprolinemia" EXACT [HP:0008358]
synonym: "increased plasma proline level" NARROW []
synonym: "increased serum proline level" NARROW []
synonym: "prolinaemia" EXACT []
synonym: "prolinemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0020237 ! increased proline level
is_a: MP:0030666 ! abnormal circulating proline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:14:49Z" xsd:dateTime

[Term]
id: MP:0030668
name: decreased circulating proline level
def: "reduction in the amount per unit of blood of proline, an alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2; proline is a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins" [CHEBI:26271, GO:0006560, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma proline level" NARROW []
synonym: "decreased serum proline level" NARROW []
synonym: "hypoprolinaemia" EXACT []
synonym: "hypoprolinemia" EXACT []
synonym: "reduced circulating proline level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0020238 ! decreased proline level
is_a: MP:0030666 ! abnormal circulating proline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:20:17Z" xsd:dateTime

[Term]
id: MP:0030669
name: abnormal circulating phenylalanine level
def: "aberrant concentration in the blood of phenylalanine (2-amino-3-phenylpropanoic acid), an aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group; it is an essential alpha-amino acid and the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
synonym: "abnormal plasma phenylalanine level" NARROW []
synonym: "abnormal serum phenylalanine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030696 ! abnormal phenylalanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:25:52Z" xsd:dateTime

[Term]
id: MP:0030670
name: increased circulating phenylalanine level
def: "increase in the amount per unit of blood of phenylalanine (2-amino-3-phenylpropanoic acid), an essential alpha-amino acid that is the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
synonym: "hyperphenylalaninaemia" EXACT []
synonym: "hyperphenylalaninemia" EXACT [HP:0004923]
synonym: "increased plasma phenylalanine level" NARROW []
synonym: "increased serum phenylalanine level" NARROW []
synonym: "phenylalaninaemia" EXACT []
synonym: "phenylalaninemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030669 ! abnormal circulating phenylalanine level
is_a: MP:0030697 ! increased phenylalanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:31:58Z" xsd:dateTime

[Term]
id: MP:0030671
name: decreased circulating phenylalanine level
def: "reduction in the amount per unit of blood of phenylalanine (2-amino-3-phenylpropanoic acid), an essential alpha-amino acid that is the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
synonym: "decreased plasma phenylalanine level" NARROW []
synonym: "decreased serum phenylalanine level" NARROW []
synonym: "hypophenylalaninaemia" EXACT []
synonym: "hypophenylalaninemia" EXACT []
synonym: "reduced circulating phenylalanine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030669 ! abnormal circulating phenylalanine level
is_a: MP:0030698 ! decreased phenylalanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:36:51Z" xsd:dateTime

[Term]
id: MP:0030672
name: abnormal circulating alanine level
def: "aberrant concentration in the blood of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma alanine level" NARROW []
synonym: "abnormal serum alanine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0031638 ! abnormal alanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:43:30Z" xsd:dateTime

[Term]
id: MP:0030673
name: increased circulating alanine level
def: "increase in the amount per unit of blood of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "alaninaemia" EXACT []
synonym: "alaninemia" EXACT []
synonym: "hyperalaninaemia" EXACT []
synonym: "hyperalaninemia" EXACT [HP:0003348]
synonym: "increased plasma alanine level" NARROW []
synonym: "increased serum alanine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030672 ! abnormal circulating alanine level
is_a: MP:0031640 ! increased alanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:47:39Z" xsd:dateTime

[Term]
id: MP:0030674
name: decreased circulating alanine level
def: "reduction in the amount per unit of blood of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma alanine level" NARROW []
synonym: "decreased serum alanine level" NARROW []
synonym: "hypoalaninaemia" EXACT []
synonym: "hypoalaninemia" EXACT []
synonym: "reduced circulating alanine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030672 ! abnormal circulating alanine level
is_a: MP:0031639 ! decreased alanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-08-30T12:52:08Z" xsd:dateTime

[Term]
id: MP:0030675
name: abnormal acetylcholine level
def: "anomaly in the amount of acetylcholine, an ester of acetic acid and choline; acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems; it also acts as a paracrine signal in various non-neural tissues" [CHEBI:15355, GO:0008291]
synonym: "abnormal Ach level" EXACT []
is_a: MP:0003953 ! abnormal hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T06:48:03Z" xsd:dateTime

[Term]
id: MP:0030676
name: increased acetylcholine level
def: "greater than the normal amount of acetylcholine, an ester of acetic acid and choline; acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems; it also acts as a paracrine signal in various non-neural tissues" [CHEBI:15355, GO:0008291, https://orcid.org/0000-0002-6490-7723]
synonym: "increased Ach level" EXACT []
is_a: MP:0014454 ! increased hormone level
is_a: MP:0030675 ! abnormal acetylcholine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T06:55:09Z" xsd:dateTime

[Term]
id: MP:0030677
name: abnormal hydroxyproline level
def: "anomaly in the amount of hydroxyproline, a proline derivative that is proline substituted by at least one hydroxy group; hydroxyproline is non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741, https://pubchem.ncbi.nlm.nih.gov/compound/L-Hydroxyproline]
is_a: MP:0005332 ! abnormal amino acid level
is_a: MP:0021145 ! abnormal amino acid derivative level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:05:10Z" xsd:dateTime

[Term]
id: MP:0030678
name: increased hydroxyproline level
def: "increase in the amount of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741, https://orcid.org/0000-0002-6490-7723, https://pubchem.ncbi.nlm.nih.gov/compound/L-Hydroxyproline]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030677 ! abnormal hydroxyproline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:11:31Z" xsd:dateTime

[Term]
id: MP:0030679
name: decreased hydroxyproline level
def: "reduction in the amount of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741, https://orcid.org/0000-0002-6490-7723, https://pubchem.ncbi.nlm.nih.gov/compound/L-Hydroxyproline]
synonym: "reduced hydroxyproline level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030677 ! abnormal hydroxyproline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:16:19Z" xsd:dateTime

[Term]
id: MP:0030680
name: abnormal circulating hydroxyproline level
def: "anomaly in the amount per unit of blood of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741, https://orcid.org/0000-0002-6490-7723, https://pubchem.ncbi.nlm.nih.gov/compound/L-Hydroxyproline]
synonym: "abnormal plasma hydroxyproline level" NARROW []
synonym: "abnormal serum hydroxyproline level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030677 ! abnormal hydroxyproline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:20:17Z" xsd:dateTime

[Term]
id: MP:0030681
name: increased circulating hydroxyproline level
def: "increase in the amount per unit of blood of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix" [CHEBI:24741, https://orcid.org/0000-0002-6490-7723, https://pubchem.ncbi.nlm.nih.gov/compound/L-Hydroxyproline]
synonym: "hydroxyprolinaemia" EXACT []
synonym: "hydroxyprolinemia" EXACT [HP:0003260]
synonym: "increased plasma hydroxyproline level" NARROW []
synonym: "increased serum hydroxyproline level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030678 ! increased hydroxyproline level
is_a: MP:0030680 ! abnormal circulating hydroxyproline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:29:28Z" xsd:dateTime

[Term]
id: MP:0030682
name: hydroxyprolinuria
def: "excretion of excessive amounts of hydroxyproline in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated urinary hydroxyproline" EXACT [HP:0003080]
synonym: "increased urine hydroxyproline level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030678 ! increased hydroxyproline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T07:42:04Z" xsd:dateTime

[Term]
id: MP:0030683
name: abnormal cystathionine level
def: "anomaly in the amount of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:13:58Z" xsd:dateTime

[Term]
id: MP:0030684
name: increased cystathionine level
def: "increase in the amount of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030683 ! abnormal cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:19:29Z" xsd:dateTime

[Term]
id: MP:0030685
name: decreased cystathionine level
def: "reduction in the amount of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
synonym: "reduced cystathionine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030683 ! abnormal cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:22:15Z" xsd:dateTime

[Term]
id: MP:0030686
name: abnormal circulating cystathionine level
def: "anomaly in the amount per unit of blood of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
comment: cystathionine can be directly interconverted to cysteine; cystathionine is not normally detectable in plasma {xref="HP:0003286"}
synonym: "abnormal plasma cystathionine level" NARROW []
synonym: "abnormal serum cystathionine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030683 ! abnormal cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:25:28Z" xsd:dateTime

[Term]
id: MP:0030687
name: increased circulating cystathionine level
def: "increase in the amount per unit of blood of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
comment: cystathionine can be directly interconverted to cysteine; cystathionine is not normally detectable in plasma {xref="HP:0003286"}
synonym: "cystathioninaemia" EXACT []
synonym: "cystathioninemia" EXACT [HP:0003286]
synonym: "hypercystathioninaemia" EXACT []
synonym: "hypercystathioninemia" EXACT []
synonym: "increased plasma cystathionine level" NARROW []
synonym: "increased serum cystathionine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030684 ! increased cystathionine level
is_a: MP:0030686 ! abnormal circulating cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:31:18Z" xsd:dateTime

[Term]
id: MP:0030688
name: decreased circulating cystathionine level
def: "reduction in the amount per unit of blood of cystathionine, a modified amino acid generated by enzymic means from homocysteine and serine; cystathionine is an intermediate in the synthesis of cysteine" [CHEBI:17755, https://en.wikipedia.org/wiki/Cystathionine]
synonym: "decreased plasma cystathionine level" NARROW []
synonym: "decreased serum cystathionine level" NARROW []
synonym: "reduced circulating cystathionine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030685 ! decreased cystathionine level
is_a: MP:0030686 ! abnormal circulating cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:39:10Z" xsd:dateTime

[Term]
id: MP:0030689
name: cystathioninuria
def: "excretion of excessive amounts of cystathionine in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "high urine cystathionine levels" EXACT [HP:0003153]
synonym: "increased urine cystathionine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030684 ! increased cystathionine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T08:53:04Z" xsd:dateTime

[Term]
id: MP:0030690
name: abnormal serine level
def: "anomaly in the amount of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group; serine participates in the biosynthesis of purines and pyrimidines, is the precursor to glycine and cysteine and to numerous metabolites including sphingolipids and folate, and is often a hydrogen donor in enzymes, such as trypsin and chymotrypsin, playing a key role in their function as catalysts" [CHEBI:17822, https://en.wikipedia.org/wiki/Serine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:07:33Z" xsd:dateTime

[Term]
id: MP:0030691
name: increased serine level
def: "increase in the amount of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group" [CHEBI:17822, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030690 ! abnormal serine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:12:49Z" xsd:dateTime

[Term]
id: MP:0030692
name: decreased serine level
def: "reduction in the amount of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group" [CHEBI:17822, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced serine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030690 ! abnormal serine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:17:10Z" xsd:dateTime

[Term]
id: MP:0030693
name: abnormal circulating serine level
def: "anomaly in the amount per unit of blood of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group" [CHEBI:17822, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma serine level" NARROW []
synonym: "abnormal serum serine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030690 ! abnormal serine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:20:29Z" xsd:dateTime

[Term]
id: MP:0030694
name: increased circulating serine level
def: "increase in the amount per unit of blood of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group" [CHEBI:17822, https://orcid.org/0000-0002-6490-7723]
synonym: "hyperserinaemia" EXACT []
synonym: "hyperserinemia" EXACT []
synonym: "increased plasma serine level" NARROW []
synonym: "increased serum serine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030691 ! increased serine level
is_a: MP:0030693 ! abnormal circulating serine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:24:29Z" xsd:dateTime

[Term]
id: MP:0030695
name: decreased circulating serine level
def: "reduction in the amount per unit of blood of serine, 2-amino-3-hydroxypropanoic acid, a non-essential alpha-amino acid that is alanine substituted at position 3 by a hydroxy group" [CHEBI:17822, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma serine level" NARROW []
synonym: "decreased serum serine level" NARROW []
synonym: "hyposerinaemia" EXACT []
synonym: "hyposerinemia" EXACT [HP:0012279]
synonym: "reduced circulating serine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030692 ! decreased serine level
is_a: MP:0030693 ! abnormal circulating serine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:29:08Z" xsd:dateTime

[Term]
id: MP:0030696
name: abnormal phenylalanine level
def: "anomaly in the amount of phenylalanine (2-amino-3-phenylpropanoic acid), an aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group; it is an essential alpha-amino acid and the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T09:43:43Z" xsd:dateTime

[Term]
id: MP:0030697
name: increased phenylalanine level
def: "increase in the amount of phenylalanine (2-amino-3-phenylpropanoic acid), an essential alpha-amino acid that is the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030696 ! abnormal phenylalanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:12:44Z" xsd:dateTime

[Term]
id: MP:0030698
name: decreased phenylalanine level
def: "reduction in the amount of phenylalanine (2-amino-3-phenylpropanoic acid), an essential alpha-amino acid that is the precursor of tyrosine, the monoamine neurotransmitters dopamine, norepinephrine and epinephrine, and the skin pigment melanin" [CHEBI:28044, https://en.wikipedia.org/wiki/Phenylalanine]
synonym: "reduced phenylalanine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030696 ! abnormal phenylalanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:15:36Z" xsd:dateTime

[Term]
id: MP:0030699
name: abnormal threonine level
def: "anomaly in the amount of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:46:37Z" xsd:dateTime

[Term]
id: MP:0030700
name: increased threonine level
def: "increase in the amount of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030699 ! abnormal threonine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:51:37Z" xsd:dateTime

[Term]
id: MP:0030701
name: decreased threonine level
def: "reduction in the amount of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
synonym: "reduced threonine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030699 ! abnormal threonine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:54:01Z" xsd:dateTime

[Term]
id: MP:0030702
name: abnormal circulating threonine level
def: "anomaly in the amount per unit of blood of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma threonine level" NARROW []
synonym: "abnormal serum threonine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030699 ! abnormal threonine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T10:57:19Z" xsd:dateTime

[Term]
id: MP:0030703
name: increased circulating threonine level
def: "increase in the amount per unit of blood of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
synonym: "hyperthreoninaemia" EXACT []
synonym: "hyperthreoninemia" EXACT [HP:0003354]
synonym: "increased plasma threonine level" NARROW []
synonym: "increased serum threonine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030700 ! increased threonine level
is_a: MP:0030702 ! abnormal circulating threonine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:00:58Z" xsd:dateTime

[Term]
id: MP:0030704
name: decreased circulating threonine level
def: "reduction in the amount per unit of blood of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins" [GO:0006566, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma threonine level" NARROW []
synonym: "decreased serum threonine level" NARROW []
synonym: "reduced circulating threonine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030701 ! decreased threonine level
is_a: MP:0030702 ! abnormal circulating threonine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:06:27Z" xsd:dateTime

[Term]
id: MP:0030705
name: abnormal glutamine level
def: "anomaly in the amount of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states; glutamine plays several important roles, including protein and glutathione synthesis, energy production, acid-base balance, maintenance of optimal antioxidant status, intestinal integrity, immune function, gluconeogenesis, nitrogen transport, and neurotransmitter, nucleotide and nucleic acid synthesis" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:20:33Z" xsd:dateTime

[Term]
id: MP:0030706
name: increased glutamine level
def: "increase in the amount of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030705 ! abnormal glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:32:11Z" xsd:dateTime

[Term]
id: MP:0030707
name: decreased glutamine level
def: "reduction in the amount of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
synonym: "reduced glutamine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030705 ! abnormal glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:49:15Z" xsd:dateTime

[Term]
id: MP:0030708
name: abnormal circulating glutamine level
def: "anomaly in the amount per unit of blood of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
synonym: "abnormal plasma glutamine level" NARROW []
synonym: "abnormal serum glutamine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030705 ! abnormal glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:52:35Z" xsd:dateTime

[Term]
id: MP:0030709
name: increased circulating glutamine level
def: "increase in the amount per unit of blood of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
synonym: "hyperglutaminaemia" EXACT []
synonym: "hyperglutaminemia" EXACT [HP:0003217]
synonym: "increased plasma glutamine level" NARROW []
synonym: "increased serum glutamine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030706 ! increased glutamine level
is_a: MP:0030708 ! abnormal circulating glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T11:57:24Z" xsd:dateTime

[Term]
id: MP:0030710
name: decreased circulating glutamine level
def: "reduction in the amount per unit of blood of glutamine, a non-essential alpha-amino acid synthesized from glutamate and ammonia that may become conditionally essential in hypercatabolic states" [https://books.google.com/books?isbn=145572503X, https://en.wikipedia.org/wiki/Glutamine]
synonym: "decreased plasma glutamine level" NARROW []
synonym: "decreased serum glutamine level" NARROW []
synonym: "hypoglutaminaemia" EXACT []
synonym: "hypoglutaminemia" EXACT []
synonym: "reduced circulating glutamine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030707 ! decreased glutamine level
is_a: MP:0030708 ! abnormal circulating glutamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:02:38Z" xsd:dateTime

[Term]
id: MP:0030711
name: abnormal isoleucine level
def: "anomaly in the amount of isoleucine, a 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration; it is an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [CHEBI:24898, http://www.aminoacidsguide.com/Ile.html]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:18:23Z" xsd:dateTime

[Term]
id: MP:0030712
name: increased isoleucine level
def: "increase in the amount of isoleucine, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [http://www.aminoacidsguide.com/Ile.html]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030711 ! abnormal isoleucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:29:13Z" xsd:dateTime

[Term]
id: MP:0030713
name: decreased isoleucine level
def: "reduction in the amount of isoleucine, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [http://www.aminoacidsguide.com/Ile.html]
synonym: "reduced isoleucine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030711 ! abnormal isoleucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:33:32Z" xsd:dateTime

[Term]
id: MP:0030714
name: abnormal circulating isoleucine level
def: "anomaly in the amount per unit of blood of isoleucine, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [http://www.aminoacidsguide.com/Ile.html]
synonym: "abnormal plasma isoleucine level" NARROW []
synonym: "abnormal serum isoleucine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030711 ! abnormal isoleucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:36:38Z" xsd:dateTime

[Term]
id: MP:0030715
name: increased circulating isoleucine level
def: "increase in the amount per unit of blood of isoleucine, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [http://www.aminoacidsguide.com/Ile.html]
synonym: "hyperisoleucinaemia" EXACT []
synonym: "hyperisoleucinemia" EXACT [HP:0010913]
synonym: "increased plasma isoleucine level" NARROW []
synonym: "increased serum isoleucine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030712 ! increased isoleucine level
is_a: MP:0030714 ! abnormal circulating isoleucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:40:18Z" xsd:dateTime

[Term]
id: MP:0030716
name: decreased circulating isoleucine level
def: "reduction in the amount per unit of blood of isoleucine, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins and is important in hemoglobin synthesis and regulation of blood sugar and energy levels" [http://www.aminoacidsguide.com/Ile.html]
synonym: "decreased plasma isoleucine level" NARROW []
synonym: "decreased serum isoleucine level" NARROW []
synonym: "hypoisoleucinaemia" EXACT []
synonym: "hypoisoleucinemia" EXACT []
synonym: "reduced circulating isoleucine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030713 ! decreased isoleucine level
is_a: MP:0030714 ! abnormal circulating isoleucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T12:45:13Z" xsd:dateTime

[Term]
id: MP:0030717
name: abnormal circulating lysine level
def: "aberrant concentration in the blood of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis; in humans, lysine plays additional roles in the crosslinking of collagen polypeptides, uptake of essential mineral nutrients, and in the production of carnitine, which is key in fatty acid metabolism; it is also involved in epigenetic regulation by means of histone modification" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
synonym: "abnormal plasma lysine level" NARROW []
synonym: "abnormal serum lysine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030720 ! abnormal lysine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:01:34Z" xsd:dateTime

[Term]
id: MP:0030718
name: increased circulating lysine level
def: "increase in the amount per unit of blood of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
synonym: "hyperlysinaemia" EXACT []
synonym: "hyperlysinemia" EXACT [HP:0002161]
synonym: "increased plasma lysine level" NARROW []
synonym: "increased serum lysine level" NARROW []
synonym: "lysinaemia" EXACT []
synonym: "lysinemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030717 ! abnormal circulating lysine level
is_a: MP:0030721 ! increased lysine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:09:29Z" xsd:dateTime

[Term]
id: MP:0030719
name: decreased circulating lysine level
def: "reduction in the amount per unit of blood of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
synonym: "decreased plasma lysine level" NARROW []
synonym: "decreased serum lysine level" NARROW []
synonym: "hypolysinaemia" EXACT []
synonym: "hypolysinemia" EXACT []
synonym: "reduced circulating lysine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030717 ! abnormal circulating lysine level
is_a: MP:0030722 ! decreased lysine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:16:12Z" xsd:dateTime

[Term]
id: MP:0030720
name: abnormal lysine level
def: "anomaly in the amount of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis; in humans, lysine plays additional roles in the crosslinking of collagen polypeptides, uptake of essential mineral nutrients, and in the production of carnitine, which is key in fatty acid metabolism; it is also involved in epigenetic regulation by means of histone modification" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:20:46Z" xsd:dateTime

[Term]
id: MP:0030721
name: increased lysine level
def: "increase in the amount of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030720 ! abnormal lysine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:24:06Z" xsd:dateTime

[Term]
id: MP:0030722
name: decreased lysine level
def: "reduction in the amount of lysine (2,6-diaminohexanoic acid), an essential alpha-amino acid used in protein biosynthesis" [CHEBI:25094, https://en.wikipedia.org/wiki/Lysine]
synonym: "reduced lysine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030720 ! abnormal lysine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:27:55Z" xsd:dateTime

[Term]
id: MP:0030723
name: abnormal valine level
def: "anomaly in the amount of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:53:29Z" xsd:dateTime

[Term]
id: MP:0030724
name: increased valine level
def: "increase in the amount of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030723 ! abnormal valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T13:57:08Z" xsd:dateTime

[Term]
id: MP:0030725
name: decreased valine level
def: "reduction in the amount of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
synonym: "reduced valine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030723 ! abnormal valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T14:00:38Z" xsd:dateTime

[Term]
id: MP:0030726
name: abnormal circulating valine level
def: "aberrant concentration in the blood of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
synonym: "abnormal plasma valine level" NARROW []
synonym: "abnormal serum valine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030723 ! abnormal valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T14:04:19Z" xsd:dateTime

[Term]
id: MP:0030727
name: increased circulating valine level
def: "increase in the amount per unit of blood of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
synonym: "hypervalinaemia" EXACT []
synonym: "hypervalinemia" EXACT [HP:0010910]
synonym: "increased plasma valine level" NARROW []
synonym: "increased serum valine level" NARROW []
synonym: "valinaemia" EXACT []
synonym: "valinemia" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030724 ! increased valine level
is_a: MP:0030726 ! abnormal circulating valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T14:12:16Z" xsd:dateTime

[Term]
id: MP:0030728
name: decreased circulating valine level
def: "reduction in the amount per unit of blood of valine (2-amino-3-methylbutanoic acid), a branched-chain essential amino acid that is used in the biosynthesis of proteins, has stimulant activity, and promotes muscle growth and tissue repair" [GO:0006573, https://pubchem.ncbi.nlm.nih.gov/compound/L-valine]
synonym: "decreased plasma valine level" NARROW []
synonym: "decreased serum valine level" NARROW []
synonym: "hypovalinaemia" EXACT []
synonym: "hypovalinemia" EXACT []
synonym: "reduced circulating valine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030725 ! decreased valine level
is_a: MP:0030726 ! abnormal circulating valine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-06T14:17:40Z" xsd:dateTime

[Term]
id: MP:0030729
name: abnormal beta-alanine level
def: "anomaly in the amount of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine; it occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins" [GO:0019482]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T09:43:04Z" xsd:dateTime

[Term]
id: MP:0030730
name: increased beta-alanine level
def: "increase in the amount of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine; it occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins" [GO:0019482]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030729 ! abnormal beta-alanine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T09:47:02Z" xsd:dateTime

[Term]
id: MP:0030731
name: abnormal gamma-aminobutyric acid level
def: "anomaly in the amount of gamma-aminobutyric acid, a non-proteinogenic gamma-amino acid that is not incorporated into proteins and acts as the chief inhibitory neurotransmitter in the mammalian central nervous system" [CHEBI:16865, https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid]
synonym: "abnormal 4-aminobutanoic acid level" EXACT []
synonym: "abnormal 4-aminobutyric acid level" EXACT []
synonym: "abnormal GABA level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T09:55:42Z" xsd:dateTime

[Term]
id: MP:0030732
name: increased gamma-aminobutyric acid level
def: "increase in the amount of gamma-aminobutyric acid, a non-proteinogenic gamma-amino acid that is not incorporated into proteins and acts as the chief inhibitory neurotransmitter in the mammalian central nervous system" [CHEBI:16865, https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid]
synonym: "increased 4-aminobutanoic acid level" EXACT []
synonym: "increased 4-aminobutyric acid level" EXACT []
synonym: "increased GABA level" EXACT []
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030731 ! abnormal gamma-aminobutyric acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:02:42Z" xsd:dateTime

[Term]
id: MP:0030733
name: decreased gamma-aminobutyric acid level
def: "reduction in the amount of gamma-aminobutyric acid, a non-proteinogenic gamma-amino acid that is not incorporated into proteins and acts as the chief inhibitory neurotransmitter in the mammalian central nervous system" [CHEBI:16865, https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid]
synonym: "decreased 4-aminobutanoic acid level" EXACT []
synonym: "decreased 4-aminobutyric acid level" EXACT []
synonym: "decreased GABA level" EXACT []
synonym: "reduced GABA level" EXACT []
synonym: "reduced gamma-aminobutyric acid level" EXACT []
is_a: MP:0030731 ! abnormal gamma-aminobutyric acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:06:38Z" xsd:dateTime

[Term]
id: MP:0030734
name: increased urine gamma-aminobutyric acid level
def: "excretion of excessive amounts of gamma-aminobutyric in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "GABAuria" EXACT []
synonym: "gamma-aminobutyric aciduria" EXACT []
synonym: "increased urine 4-aminobutanoic acid level" EXACT []
synonym: "increased urine 4-aminobutyric acid level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030732 ! increased gamma-aminobutyric acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:11:01Z" xsd:dateTime

[Term]
id: MP:0030735
name: abnormal glutamic acid level
def: "anomaly in the amount of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [GO:0006536, https://en.wikipedia.org/wiki/Glutamic_acid]
synonym: "abnormal glutamate level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:23:51Z" xsd:dateTime

[Term]
id: MP:0030736
name: increased glutamic acid level
def: "increase in the amount of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [GO:0006536, https://en.wikipedia.org/wiki/Glutamic_acid]
synonym: "increased glutamate level" EXACT []
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030735 ! abnormal glutamic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:42:13Z" xsd:dateTime

[Term]
id: MP:0030737
name: decreased glutamic acid level
def: "reduction in the amount of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [GO:0006536, https://en.wikipedia.org/wiki/Glutamic_acid]
synonym: "decreased glutamate level" EXACT []
synonym: "reduced glutamate level" EXACT []
synonym: "reduced glutamic acid level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030735 ! abnormal glutamic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:45:19Z" xsd:dateTime

[Term]
id: MP:0030738
name: abnormal circulating glutamic acid level
def: "aberrant concentration in the blood of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [GO:0006536, https://en.wikipedia.org/wiki/Glutamic_acid]
synonym: "abnormal plasma glutamate level" NARROW []
synonym: "abnormal plasma glutamic acid level" NARROW []
synonym: "abnormal serum glutamate level" NARROW []
synonym: "abnormal serum glutamic acid level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030735 ! abnormal glutamic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:49:14Z" xsd:dateTime

[Term]
id: MP:0030739
name: increased circulating glutamic acid level
def: "increase in the amount per unit of blood of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased plasma glutamate level" NARROW []
synonym: "increased plasma glutamic acid level" NARROW []
synonym: "increased serum glutamate level" NARROW []
synonym: "increased serum glutamic acid level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030736 ! increased glutamic acid level
is_a: MP:0030738 ! abnormal circulating glutamic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:54:07Z" xsd:dateTime

[Term]
id: MP:0030740
name: decreased circulating glutamic acid level
def: "reduction in the amount per unit of blood of glutamic acid (2-aminopentanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, glutamate, is the major excitatory neurotransmitter in the mammalian central nervous system and also serves as the metabolic precursor of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma glutamate level" NARROW []
synonym: "decreased plasma glutamic acid level" NARROW []
synonym: "decreased serum glutamate level" NARROW []
synonym: "decreased serum glutamic acid level" NARROW []
synonym: "reduced circulating glutamic acid level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030737 ! decreased glutamic acid level
is_a: MP:0030738 ! abnormal circulating glutamic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T10:58:16Z" xsd:dateTime

[Term]
id: MP:0030741
name: abnormal aspartic acid level
def: "anomaly in the amount of aspartic acid (2-aminobutanedioic acid), a non-essential alpha-amino used in the biosynthesis of proteins; its anion form, aspartate, may play a role in excitatory neurotransmission" [GO:0006532, https://en.wikipedia.org/wiki/Aspartic_acid]
synonym: "abnormal aspartate level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T11:13:37Z" xsd:dateTime

[Term]
id: MP:0030742
name: increased aspartic acid level
def: "increase in the amount of aspartic acid (2-aminobutanedioic acid) or its anion form, aspartate" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased aspartate level" EXACT []
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030741 ! abnormal aspartic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T11:28:20Z" xsd:dateTime

[Term]
id: MP:0030743
name: decreased aspartic acid level
def: "reduction in the amount of aspartic acid (2-aminobutanedioic acid) or its anion form, aspartate" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased aspartate level" EXACT []
synonym: "reduced aspartate level" EXACT []
synonym: "reduced aspartic acid level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030741 ! abnormal aspartic acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-10T11:31:56Z" xsd:dateTime

[Term]
id: MP:0030744
name: abnormal circulating homocitrulline level
def: "aberrant concentration in the blood of homocitrulline, an amino acid and a metabolite of ornithine in mammalian metabolism" [https://en.wikipedia.org/wiki/Homocitrulline]
synonym: "abnormal plasma homocitrulline level" EXACT []
synonym: "abnormal serum homocitrulline level" EXACT []
is_a: MP:0005311 ! abnormal circulating amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:16:42Z" xsd:dateTime

[Term]
id: MP:0030745
name: increased circulating homocitrulline level
def: "increase in the amount per unit of blood of homocitrulline, an amino acid and a metabolite of ornithine in mammalian metabolism" [https://en.wikipedia.org/wiki/Homocitrulline, https://orcid.org/0000-0002-6490-7723]
synonym: "increased plasma homocitrulline level" EXACT []
synonym: "increased serum homocitrulline level" EXACT []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030744 ! abnormal circulating homocitrulline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:28:26Z" xsd:dateTime

[Term]
id: MP:0030746
name: abnormal leucine level
def: "anomaly in the amount of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
is_a: MP:0005332 ! abnormal amino acid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:37:04Z" xsd:dateTime

[Term]
id: MP:0030747
name: increased leucine level
def: "increase in the amount of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0030746 ! abnormal leucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:40:23Z" xsd:dateTime

[Term]
id: MP:0030748
name: decreased leucine level
def: "reduction in the amount of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
synonym: "reduced leucine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0030746 ! abnormal leucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:43:00Z" xsd:dateTime

[Term]
id: MP:0030749
name: abnormal circulating leucine level
def: "anomaly in the amount per unit of blood of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
synonym: "abnormal plasma leucine level" NARROW []
synonym: "abnormal serum leucine level" NARROW []
is_a: MP:0005311 ! abnormal circulating amino acid level
is_a: MP:0030746 ! abnormal leucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:46:41Z" xsd:dateTime

[Term]
id: MP:0030750
name: increased circulating leucine level
def: "increase in the amount per unit of blood of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
synonym: "hyperleucinaemia" EXACT []
synonym: "hyperleucinemia" EXACT [HP:0010911]
synonym: "increased plasma leucine level" NARROW []
synonym: "increased serum leucine level" NARROW []
is_a: MP:0014530 ! increased circulating amino acid level
is_a: MP:0030747 ! increased leucine level
is_a: MP:0030749 ! abnormal circulating leucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:50:29Z" xsd:dateTime

[Term]
id: MP:0030751
name: decreased circulating leucine level
def: "reduction in the amount per unit of blood of leucine, 2-amino-4-methylpentanoic acid, an essential branched-chain alpha-amino acid that is used in the biosynthesis of proteins" [GO:0006551, https://en.wikipedia.org/wiki/Leucine]
synonym: "decreased plasma leucine level" NARROW []
synonym: "decreased serum leucine level" NARROW []
synonym: "hypoleucinaemia" EXACT []
synonym: "hypoleucinemia" EXACT []
synonym: "reduced circulating leucine level" EXACT []
is_a: MP:0014531 ! decreased circulating amino acid level
is_a: MP:0030748 ! decreased leucine level
is_a: MP:0030749 ! abnormal circulating leucine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-11T11:54:36Z" xsd:dateTime

[Term]
id: MP:0030752
name: abnormal choline level
def: "any anomaly in the amount of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine" [GO:0019695]
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:30:59Z" xsd:dateTime

[Term]
id: MP:0030753
name: decreased choline level
def: "less than the normal amount of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine" [GO:0019695]
synonym: "reduced choline level" EXACT []
is_a: MP:0030752 ! abnormal choline level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:36:27Z" xsd:dateTime

[Term]
id: MP:0030754
name: abnormal histamine level
def: "anomaly in the amount of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine]
is_a: MP:0002503 ! abnormal histamine physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:51:03Z" xsd:dateTime

[Term]
id: MP:0030755
name: increased histamine level
def: "increase in the amount of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine]
is_a: MP:0030754 ! abnormal histamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:54:20Z" xsd:dateTime

[Term]
id: MP:0030756
name: decreased histamine level
def: "reduction in the amount of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine]
synonym: "reduced histamine level" EXACT []
is_a: MP:0030754 ! abnormal histamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:57:31Z" xsd:dateTime

[Term]
id: MP:0030757
name: abnormal circulating histamine level
def: "aberrant concentration in the blood of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal plasma histamine level" NARROW []
synonym: "abnormal serum histamine level" NARROW []
is_a: MP:0009642 ! abnormal blood homeostasis
is_a: MP:0030754 ! abnormal histamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T08:59:47Z" xsd:dateTime

[Term]
id: MP:0030758
name: increased circulating histamine level
def: "increase in the amount per unit of blood of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine, https://orcid.org/0000-0002-6490-7723]
synonym: "increased plasma histamine level" NARROW []
synonym: "increased serum histamine level" NARROW []
is_a: MP:0030755 ! increased histamine level
is_a: MP:0030757 ! abnormal circulating histamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T09:03:37Z" xsd:dateTime

[Term]
id: MP:0030759
name: decreased circulating histamine level
def: "reduction in the amount per unit of blood of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching" [https://en.wikipedia.org/wiki/Histamine, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma histamine level" NARROW []
synonym: "decreased serum histamine level" NARROW []
synonym: "reduced circulating histamine level" EXACT []
is_a: MP:0030756 ! decreased histamine level
is_a: MP:0030757 ! abnormal circulating histamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T09:15:50Z" xsd:dateTime

[Term]
id: MP:0030760
name: increased circulating dopamine level
def: "greater than the normal blood amount of dopamine" [https://orcid.org/0000-0002-6490-7723, MESH:D02.092.211.215.311.342]
synonym: "increased plasma dopamine level" EXACT []
synonym: "increased serum dopamine level" EXACT []
is_a: MP:0001906 ! increased dopamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T09:23:42Z" xsd:dateTime

[Term]
id: MP:0030761
name: increased adrenaline level
def: "greater than the normal amount of adrenaline, a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-6490-7723, MESH:D02.033.100.291.310]
synonym: "increased adrenal adrenaline level" NARROW []
synonym: "increased adrenal epinephrine level" NARROW []
synonym: "increased epinephrine level" EXACT []
is_a: MP:0003962 ! abnormal adrenaline level
is_a: MP:0014454 ! increased hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T09:38:32Z" xsd:dateTime

[Term]
id: MP:0030762
name: decreased adrenaline level
def: "less than the normal amount of adrenaline, a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [https://orcid.org/0000-0002-6490-7723, MESH:D02.033.100.291.310]
synonym: "decreased adrenal adrenaline level" NARROW []
synonym: "decreased adrenal epinephrine level" NARROW []
synonym: "decreased epinephrine level" EXACT []
synonym: "reduced epinephrine level" EXACT []
is_a: MP:0003962 ! abnormal adrenaline level
is_a: MP:0014455 ! decreased hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T09:44:24Z" xsd:dateTime

[Term]
id: MP:0030763
name: abnormal anandamide level
def: "anomaly in the amount of anandamide, N-arachidonoylethanolamine, a fatty acid neurotransmitter derived from the non-oxidative metabolism of arachidonic acid; it is an endocannabinoid that binds to cannabinoid receptors and influences mood, appetite, motivation, perception of pain and pleasure, and memory" [https://en.wikipedia.org/wiki/Anandamide, https://medical-dictionary.thefreedictionary.com/anandamide]
synonym: "abnormal AEA level" EXACT []
is_a: MP:0001547 ! abnormal lipid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:02:03Z" xsd:dateTime

[Term]
id: MP:0030764
name: increased anandamide level
def: "increase in the amount of anandamide, N-arachidonoylethanolamine, a fatty acid neurotransmitter derived from the non-oxidative metabolism of arachidonic acid; it is an endocannabinoid that binds to cannabinoid receptors and influences mood, appetite, motivation, perception of pain and pleasure, and memory" [https://en.wikipedia.org/wiki/Anandamide, https://medical-dictionary.thefreedictionary.com/anandamide]
synonym: "increased AEA level" EXACT []
is_a: MP:0014460 ! increased lipid level
is_a: MP:0030763 ! abnormal anandamide level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:05:18Z" xsd:dateTime

[Term]
id: MP:0030765
name: decreased anandamide level
def: "reduction in the amount of anandamide, N-arachidonoylethanolamine, a fatty acid neurotransmitter derived from the non-oxidative metabolism of arachidonic acid; it is an endocannabinoid that binds to cannabinoid receptors and influences mood, appetite, motivation, perception of pain and pleasure, and memory" [https://en.wikipedia.org/wiki/Anandamide, https://medical-dictionary.thefreedictionary.com/anandamide]
synonym: "decreased AEA level" EXACT []
synonym: "reduced AEA level" EXACT []
synonym: "reduced anandamide level" EXACT []
is_a: MP:0014461 ! decreased lipid level
is_a: MP:0030763 ! abnormal anandamide level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:07:49Z" xsd:dateTime

[Term]
id: MP:0030766
name: increased urine catecholamine level
def: "greater than the normal urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated urinary catecholamines" EXACT [HP:0011976]
synonym: "increased urinary catecholamine concentration" EXACT []
is_a: MP:0011478 ! abnormal urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:37:29Z" xsd:dateTime

[Term]
id: MP:0030767
name: decreased urine catecholamine level
def: "less than the normal urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urinary catecholamine concentration" EXACT [HP:0045012]
synonym: "reduced urine catecholamine level" EXACT []
is_a: MP:0011478 ! abnormal urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:42:16Z" xsd:dateTime

[Term]
id: MP:0030768
name: increased urine dopamine level
def: "an increased amount of dopamine in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated urinary dopamine" EXACT [HP:0011979]
is_a: MP:0001906 ! increased dopamine level
is_a: MP:0030766 ! increased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T10:56:33Z" xsd:dateTime

[Term]
id: MP:0030769
name: decreased urine dopamine level
def: "a reduced amount of dopamine in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced urine dopamine level" EXACT []
is_a: MP:0005643 ! decreased dopamine level
is_a: MP:0030767 ! decreased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T11:02:09Z" xsd:dateTime

[Term]
id: MP:0030770
name: increased urine adrenaline level
def: "an increased amount of adrenaline in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated urinary epinephrine" EXACT [HP:0003639]
synonym: "increased urine epinephrine level" EXACT []
is_a: MP:0030761 ! increased adrenaline level
is_a: MP:0030766 ! increased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T11:14:23Z" xsd:dateTime

[Term]
id: MP:0030771
name: decreased urine adrenaline level
def: "a reduced amount of adrenaline in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine epinephrine level" EXACT []
synonym: "reduced urine adrenaline level" EXACT []
synonym: "reduced urine epinephrine level" EXACT []
is_a: MP:0030762 ! decreased adrenaline level
is_a: MP:0030767 ! decreased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T11:17:53Z" xsd:dateTime

[Term]
id: MP:0030772
name: increased urine noradrenaline level
def: "an increased amount of noradrenaline in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased urine norepinephrine level" EXACT []
is_a: MP:0012575 ! increased noradrenaline level
is_a: MP:0030766 ! increased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T11:21:29Z" xsd:dateTime

[Term]
id: MP:0030773
name: decreased urine noradrenaline level
def: "a reduced amount of noradrenaline in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine norepinephrine level" EXACT []
synonym: "reduced urine noradrenaline level" EXACT []
synonym: "reduced urine norepinephrine level" EXACT []
is_a: MP:0012574 ! decreased noradrenaline level
is_a: MP:0030767 ! decreased urine catecholamine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-14T11:27:43Z" xsd:dateTime

[Term]
id: MP:0030774
name: abnormal ischiofemoral ligament morphology
def: "any structural anomaly of the triangular band of strong fibers on the posterior side of the hip joint; its fibers span from the ischium at a point below and behind the acetabulum to blend with the circular fibers at the posterior end of the joint capsule and attach at the intertrochanteric line of the femur" [https://en.wikipedia.org/wiki/Ischiofemoral_ligament]
synonym: "abnormal ischiocapsular band morphology" EXACT []
synonym: "abnormal ischiocapsular ligament morphology" EXACT []
synonym: "abnormal ligament of Bertin morphology" EXACT []
is_a: MP:0005504 ! abnormal ligament morphology
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T05:53:22Z" xsd:dateTime

[Term]
id: MP:0030775
name: abnormal calcaneal tendon morphology
def: "any structural anomaly of the large, strong tendon that serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone" [https://en.wikipedia.org/wiki/Achilles_tendon]
synonym: "abnormal Achilles tendon morphology" EXACT []
synonym: "abnormal heel cord morphology" EXACT []
synonym: "abnormal tendo calcaneus morphology" EXACT []
is_a: MP:0005503 ! abnormal tendon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T06:08:58Z" xsd:dateTime

[Term]
id: MP:0030776
name: calcified calcaneal tendon
def: "pathologic deposition of calcium salts in the large, strong tendon that serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone" [https://en.wikipedia.org/wiki/Achilles_tendon, https://orcid.org/0000-0002-6490-7723]
synonym: "Achilles tendon calcification" EXACT []
synonym: "calcaneal tendon calcification" EXACT []
synonym: "calcified Achilles tendon" EXACT []
is_a: MP:0003198 ! calcified tendon
is_a: MP:0030775 ! abnormal calcaneal tendon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T06:20:55Z" xsd:dateTime

[Term]
id: MP:0030777
name: abnormal urine citrate level
def: "any anomaly in the urinary amount of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, an important intermediate in the tricarboxylic acid cycle" [GO:0006101, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006272 ! abnormal urine organic anion level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T06:39:36Z" xsd:dateTime

[Term]
id: MP:0030778
name: increased urine citrate level
def: "greater than the normal urinary amount of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, an important intermediate in the tricarboxylic acid cycle" [GO:0006101, https://orcid.org/0000-0002-6490-7723]
synonym: "hypercitraturia" EXACT [HP:0012406]
synonym: "increased urine citrate concentration" EXACT []
is_a: MP:0030777 ! abnormal urine citrate level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T06:43:36Z" xsd:dateTime

[Term]
id: MP:0030779
name: decreased urine citrate level
def: "less than the normal urinary amount of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, an important intermediate in the tricarboxylic acid cycle" [GO:0006101, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine citrate concentration" EXACT []
synonym: "hypocitraturia" EXACT [HP:0012405]
synonym: "reduced urine citrate level" EXACT []
is_a: MP:0030777 ! abnormal urine citrate level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T07:12:27Z" xsd:dateTime

[Term]
id: MP:0030780
name: increased urine glycerol level
def: "an increased amount of glycerol in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "glyceroluria" EXACT []
synonym: "increased urinary glycerol" EXACT []
synonym: "increased urinary glycerol concentration" EXACT []
is_a: MP:0003441 ! increased glycerol level
is_a: MP:0030782 ! abnormal urine glycerol level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T07:30:27Z" xsd:dateTime

[Term]
id: MP:0030781
name: decreased urine glycerol level
def: "a reduced amount of glycerol in the urine compared to the normal state" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urinary glycerol concentration" EXACT []
synonym: "reduced urine glycerol level" EXACT []
is_a: MP:0003440 ! decreased glycerol level
is_a: MP:0030782 ! abnormal urine glycerol level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T07:37:22Z" xsd:dateTime

[Term]
id: MP:0030782
name: abnormal urine glycerol level
def: "any change in the amount of glycerol in the urine" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urinary glycerol concentration" EXACT []
synonym: "abnormal urinary glycerol level" EXACT []
is_a: MP:0003439 ! abnormal glycerol level
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T07:42:54Z" xsd:dateTime

[Term]
id: MP:0030783
name: abnormal posterior longitudinal ligament morphology
def: "any structural anomaly of the ligament that runs within the vertebral canal along the posterior aspect of the vertebral bodies; it is attached mainly to the intervertebral (IV) discs and less so to the posterior aspects of the vertebral bodies from C2 (axis) to the sacrum, often bridging fat and vessels between the ligament and the bony surface; it weakly resists hyperflexion of the vertebral column and helps prevent or redirect posterior herniation of the nucleus pulposus of an IV disc; the posterior longitudinal ligament is well provided with nociceptive (pain) nerve endings and is a much narrower, somewhat weaker band than the anterior longitudinal ligament" [https://www.kenhub.com/en/library/anatomy/joints-and-ligaments-of-the-vertebral-column]
is_a: MP:0004703 ! abnormal vertebral column morphology
is_a: MP:0005504 ! abnormal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T08:03:33Z" xsd:dateTime

[Term]
id: MP:0030784
name: abnormal iliofemoral ligament morphology
def: "any structural anomaly of the strong triangular ligament that is attached by its apex to the anterior inferior spine of the ilium and acetabular margin and by its base to the intertrochanteric line of the femur; it stabilizes the hip joint and limits extension and lateral rotation of the hip" [http://www.anatomyexpert.com/app/structure/15412/702/, https://medical-dictionary.thefreedictionary.com/iliofemoral+ligament]
synonym: "abnormal Bigelow ligament morphology" EXACT []
synonym: "abnormal ligamentum iliofemorale morphology" EXACT []
synonym: "abnormal Y-ligament morphology" EXACT []
is_a: MP:0005504 ! abnormal ligament morphology
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T08:19:58Z" xsd:dateTime

[Term]
id: MP:0030785
name: abnormal falciform ligament morphology
def: "any structural anomaly of the broad and thin, sickle-shaped peritoneal ligament that attaches the liver to the anterior body wall and is a remnant of the ventral mesentery of the fetus; it is situated in an anteroposterior plane but lies obliquely so that one surface faces forward and is in contact with the peritoneum behind the right rectus abdominis and the diaphragm, while the other is directed backwards and is in contact with the left lobe of the liver" [https://en.wikipedia.org/wiki/Falciform_ligament, https://radiopaedia.org/articles/falciform-ligament, UBERON:0001247]
synonym: "abnormal ligamentum falciforme hepatis morphology" EXACT []
synonym: "abnormal liver falciform ligament morphology" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0005504 ! abnormal ligament morphology
is_a: MP:0010789 ! abnormal stomach mesentery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T08:46:40Z" xsd:dateTime

[Term]
id: MP:0030786
name: absent falciform ligament
def: "missing the broad and thin, sickle-shaped peritoneal ligament that attaches the liver to the anterior body wall and is a remnant of the ventral mesentery of the fetus; normally, it is situated in an anteroposterior plane but lies obliquely so that one surface faces forward and is in contact with the peritoneum behind the right rectus abdominis and the diaphragm, while the other is directed backwards and is in contact with the left lobe of the liver" [https://en.wikipedia.org/wiki/Falciform_ligament, https://radiopaedia.org/articles/falciform-ligament, UBERON:0001247]
synonym: "absent ligamentum falciforme hepatis" EXACT []
synonym: "absent liver falciform ligament" EXACT []
is_a: MP:0030785 ! abnormal falciform ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T08:58:46Z" xsd:dateTime

[Term]
id: MP:0030787
name: abnormal cranial suspensory ligament morphology
def: "any structural anomaly of the ligament that connects the cranial tip of the future gonad to the dorsocranial abdominal cavity; during male embryogenesis, outgrowth of the gubernaculum and regression of the CSL result in transabdominal descent of the testes, whereas in the female, development of the CSL in conjunction with failure of the gubernaculum development holds the ovaries in a position lateral to the kidney" [PMID:10319319, UBERON:0008848]
synonym: "abnormal CSL morphology" EXACT []
is_a: MP:0002160 ! abnormal reproductive system morphology
is_a: MP:0005504 ! abnormal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T09:18:31Z" xsd:dateTime

[Term]
id: MP:0030788
name: abnormal femur head morphology
def: "any structural anomaly of the highest, globular part of the thigh bone which comprises two-thirds of a sphere and articulates with the acetabulum in the pelvic bone forming the hip joint; the head is attached to the femoral body or shaft by the neck of the femur; its surface is smooth, coated with cartilage in the fresh state, except over an ovoid depression, the fovea capitis femoris, which is situated a little below and behind the center of the head, and gives attachment to the ligament of head of femur" [https://en.wikipedia.org/wiki/Femoral_head, https://en.wikipedia.org/wiki/Femur, UBERON:0006767]
synonym: "abnormal femoral head morphology" EXACT []
synonym: "abnormal head of thigh bone" EXACT [HP:0003368]
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T10:00:23Z" xsd:dateTime

[Term]
id: MP:0030789
name: abnormal femur neck morphology
def: "any structural anomaly of the flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward" [UBERON:0007119]
synonym: "abnormal collum femoris morphology" EXACT []
synonym: "abnormal femoral neck morphology" EXACT []
synonym: "abnormal neck of thigh bone" EXACT [HP:0003367]
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T10:07:52Z" xsd:dateTime

[Term]
id: MP:0030790
name: coxa vara
def: "a hip deformity that includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees; it may be congenital often syndromic, acquired, or developmental" [HP:0002812]
is_a: MP:0030789 ! abnormal femur neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T10:15:10Z" xsd:dateTime

[Term]
id: MP:0030791
name: club-shaped femur
def: "an abnormal conformation of the femur that becomes gradually enlarged at one end" [https://orcid.org/0000-0002-6490-7723]
synonym: "club-like femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T11:01:30Z" xsd:dateTime

[Term]
id: MP:0030792
name: large femur head
def: "increased size of the femur head" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged femoral head" EXACT []
synonym: "enlarged femur head" EXACT []
synonym: "increased femur head size" EXACT []
synonym: "large femoral head" EXACT []
is_a: MP:0030788 ! abnormal femur head morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T11:07:37Z" xsd:dateTime

[Term]
id: MP:0030793
name: short femur neck
def: "decreased length of the femur neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased femoral neck length" EXACT []
synonym: "decreased femur neck length" EXACT []
synonym: "short femoral neck" EXACT []
is_a: MP:0030789 ! abnormal femur neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T11:14:00Z" xsd:dateTime

[Term]
id: MP:0030794
name: broad femur neck
def: "increased width of the femur neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad femoral neck" EXACT []
synonym: "increased femur neck width" EXACT []
synonym: "wide femoral neck" EXACT []
synonym: "wide femur neck" EXACT []
is_a: MP:0030789 ! abnormal femur neck morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-20T11:17:51Z" xsd:dateTime

[Term]
id: MP:0030795
name: joint dislocation
def: "displacement of one or more bones of a joint from the normal position; common sites include the shoulder, patella, elbow, wrist, finger and hip; a partial dislocation is referred to as a subluxation" [HP:0001373, https://en.wikipedia.org/wiki/Joint_dislocation, https://www.merriam-webster.com/dictionary]
synonym: "dislocated joint" EXACT []
synonym: "dislocated joints" EXACT []
synonym: "joint dislocations" EXACT []
synonym: "joint luxation" EXACT []
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T06:34:30Z" xsd:dateTime

[Term]
id: MP:0030796
name: hip dislocation
def: "displacement of the femur from its normal location in the hip joint" [HP:0002827]
synonym: "dislocated hip" EXACT []
is_a: MP:0030795 ! joint dislocation
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T07:26:48Z" xsd:dateTime

[Term]
id: MP:0030797
name: joint laxity
def: "looseness or lack of stability of a joint; may be caused by a number of factors including intraarticular disease and injury or slacking of extraarticular structures such as joint capsules, ligaments, and muscles" [HP:0001388]
synonym: "joint instability" EXACT []
synonym: "lax joints" EXACT []
is_a: MP:0008069 ! abnormal joint mobility
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T07:44:37Z" xsd:dateTime

[Term]
id: MP:0030798
name: joint contracture
def: "chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints" [HP:0001371]
comment: A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively.
synonym: "flexion contracture" NARROW []
synonym: "flexion contractures" NARROW []
synonym: "joint contractures" EXACT []
is_a: MP:0008069 ! abnormal joint mobility
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T09:12:41Z" xsd:dateTime

[Term]
id: MP:0030799
name: abnormal tendon sheath morphology
def: "any structural anomaly of the membrane that wraps around a tendon; it allows the tendon to stretch and prevents it from adhering to the overlying fascia; tendon sheaths consist of two layers: a fibrous layer, made of tight collagenous tissue, and a synovial layer; the synovial part of the tendon sheath consists of a visceral and parietal layer separated by synovial fluid, which keeps the tendon moist and lubricated" [https://www.kenhub.com/en/library/anatomy/tendon-sheaths-in-the-foot, UBERON:0000304]
synonym: "abnormal synovial tendon sheath morphology" EXACT []
is_a: MP:0005503 ! abnormal tendon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T09:49:51Z" xsd:dateTime

[Term]
id: MP:0030800
name: abnormal patellar ligament morphology
def: "any structural anomaly of the central portion of the common tendon of the quadriceps femoris; it is attached to the apex of the patella and to the lower part of the tubercle of the tibia; it is sometimes called the patellar tendon as it is a continuation of the quadriceps tendon" [EMAPA:18509, https://en.wikipedia.org/wiki/Patellar_ligament, UBERON:0003676]
synonym: "abnormal ligamentum patellae morphology" EXACT []
synonym: "abnormal patellar tendon morphology" RELATED [UBERON:0003676]
is_a: MP:0005504 ! abnormal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T10:00:59Z" xsd:dateTime

[Term]
id: MP:0030801
name: tendonitis
def: "inflammation of a tendon" [HP:0025230]
synonym: "tendinitis" EXACT []
synonym: "tendon inflammation" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0030802 ! abnormal tendon physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T10:25:26Z" xsd:dateTime

[Term]
id: MP:0030802
name: abnormal tendon physiology
def: "any functional anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001533 ! abnormal skeleton physiology
is_a: MP:0002106 ! abnormal muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T10:48:34Z" xsd:dateTime

[Term]
id: MP:0030803
name: abnormal tendon cell morphology
def: "any structural anomaly of any of the elongated fibrocytes in which the cytoplasm is stretched between the collagen fibers of the tendon; tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibers and ground substance" [CL:0000388, https://en.wikipedia.org/wiki/Tendon_cell]
synonym: "abnormal muscle attachment cell morphology" EXACT []
synonym: "abnormal tenocyte morphology" RELATED []
is_a: MP:0005503 ! abnormal tendon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T11:08:08Z" xsd:dateTime

[Term]
id: MP:0030804
name: abnormal synovial joint morphology
def: "any structural anomaly of any joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity (e.g. temporomandibular joint, knee joint)" [EMAPA:36700, UBERON:0002217]
synonym: "abnormal articulatio synoviale morphology" EXACT []
synonym: "abnormal diarthrosis joint morphology" EXACT []
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T11:27:13Z" xsd:dateTime

[Term]
id: MP:0030805
name: abnormal limb joint morphology
def: "any structural anomaly of any joint that is part of a (free) limb" [EMAPA:36501, UBERON:0003657]
comment: most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses {xref="UBERON:0003657"}
synonym: "abnormal skeletal limb joint morphology" EXACT []
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T11:50:30Z" xsd:dateTime

[Term]
id: MP:0030806
name: abnormal autopod joint morphology
def: "any structural anomaly of any limb joint that is part of an autopod" [EMAPA:35160, UBERON:0003841]
synonym: "abnormal autopod limb joint morphology" EXACT []
synonym: "abnormal paw joint morphology" RELATED []
is_a: MP:0000572 ! abnormal autopod morphology
is_a: MP:0030805 ! abnormal limb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T11:57:25Z" xsd:dateTime

[Term]
id: MP:0030807
name: abnormal forelimb joint morphology
def: "any structural anomaly of any limb joint that is part of a forelimb" [EMAPA:19204, UBERON:0003839]
is_a: MP:0000550 ! abnormal forelimb morphology
is_a: MP:0030805 ! abnormal limb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T12:06:02Z" xsd:dateTime

[Term]
id: MP:0030808
name: abnormal hindlimb joint morphology
def: "any structural anomaly of any limb joint that is part of a hindlimb" [EMAPA:32635, UBERON:0003840]
synonym: "abnormal hind limb joint morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0030805 ! abnormal limb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-24T12:11:32Z" xsd:dateTime

[Term]
id: MP:0030809
name: abnormal humeroradial joint morphology
def: "any structural anomaly of the hinge joint between the head of the radius and the capitulum of the humerus" [UBERON:0011111]
synonym: "abnormal articulatio humeroradialis morphology" EXACT []
synonym: "abnormal humero-radial joint morphology" EXACT []
synonym: "abnormal radio-humeral joint morphology" EXACT []
synonym: "abnormal radiohumeral joint morphology" EXACT [https://radiopaedia.org/articles/elbow]
is_a: MP:0013945 ! abnormal elbow joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T07:28:32Z" xsd:dateTime

[Term]
id: MP:0030810
name: abnormal atlanto-occipital joint morphology
def: "any structural anomaly of either of a pair of condyloid synovial joints between the superior articular facets of the atlas and the condyles of the occipital bone" [https://books.google.com/books?isbn=9350901994, UBERON:0000220]
synonym: "abnormal articulatio atlanto-occipitalis morphology" EXACT []
synonym: "abnormal atlantooccipital joint morphology" EXACT []
synonym: "abnormal craniovertebral joint morphology" EXACT []
synonym: "abnormal occipito-atlantal joint morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T09:28:04Z" xsd:dateTime

[Term]
id: MP:0030811
name: abnormal hand joint morphology
def: "any structural anomaly of any skeletal joint that is part of a hand (manus)" [UBERON:0001489]
synonym: "abnormal manus joint morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030806 ! abnormal autopod joint morphology
is_a: MP:0030807 ! abnormal forelimb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T09:46:40Z" xsd:dateTime

[Term]
id: MP:0030812
name: abnormal metacarpophalangeal joint morphology
def: "any structural anomaly of any of the condylar or ellipsoid synovial joints between the heads of the metacarpal bones and the bases of the proximal phalanges" [EMAPA:19302, https://books.google.com/books?isbn=0781774357\,, UBERON:0003695]
synonym: "abnormal MCP joint morphology" EXACT []
synonym: "abnormal metacarpal-phalangeal joint morphology" EXACT []
is_a: MP:0030811 ! abnormal hand joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T09:56:32Z" xsd:dateTime

[Term]
id: MP:0030813
name: abnormal hand interphalangeal joint morphology
def: "any structural anomaly of any hinge-joints of the phalanges of the hand; there are two sets in each finger (except in the thumb): (i) proximal interphalangeal joints (PIP), those between the first (also called proximal) and second (intermediate) phalanges and (ii) distal interphalangeal joints (DIP), those between the second and third (distal) phalanges; a similar group of articulations also function in the toes" [EMAPA:36336, https://en.wikipedia.org/wiki/Interphalangeal_joints_of_the_hand, UBERON:0007722]
synonym: "abnormal forelimb digit inter-phalangeal joint" EXACT []
synonym: "abnormal interphalangeal joint of hand morphology" EXACT []
synonym: "abnormal interphalangeal joint of manus morphology" EXACT []
synonym: "abnormal manus interphalangeal joint morphology" EXACT []
is_a: MP:0012199 ! abnormal interphalangeal joint morphology
is_a: MP:0030811 ! abnormal hand joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T10:02:54Z" xsd:dateTime

[Term]
id: MP:0030814
name: abnormal wrist joint morphology
def: "any structural anomaly of the joint connecting the forelimb zeugopod skeleton with the carpal skeleton" [UBERON:0001491]
synonym: "abnormal carpal region joint morphology" EXACT []
is_a: MP:0030811 ! abnormal hand joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T10:20:09Z" xsd:dateTime

[Term]
id: MP:0030815
name: abnormal radiocarpal joint morphology
def: "any structural anomaly of the major condyloid synovial joint of the wrist which occurs proximally between the distal end of the radius and the articular disc of the distal radioulnar joint, and distally by the proximal carpal row (the scaphoid, lunate and triquetral bones)" [https://radiopaedia.org/articles/radiocarpal-joint, UBERON:0011968]
synonym: "abnormal radio-carpal joint morphology" EXACT []
synonym: "abnormal radiocarpal articulation morphology" EXACT []
is_a: MP:0030814 ! abnormal wrist joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T10:24:29Z" xsd:dateTime

[Term]
id: MP:0030816
name: abnormal shoulder joint morphology
def: "any structural anomaly of the joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone)" [UBERON:0016884]
is_a: MP:0030807 ! abnormal forelimb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T10:42:14Z" xsd:dateTime

[Term]
id: MP:0030817
name: abnormal glenohumeral joint morphology
def: "any structural anomaly of the main articulation of the shoulder joint; the glenohumeral joint is the multiaxial ball-and-socket synovial joint formed by the articular surfaces of the glenoid cavity of the scapula and the head of the humerus" [https://emedicine.medscape.com/article/1899211-overview]
is_a: MP:0030816 ! abnormal shoulder joint morphology
is_a: MP:0030820 ! abnormal pectoral girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T10:51:51Z" xsd:dateTime

[Term]
id: MP:0030818
name: abnormal girdle joint morphology
def: "any structural anomaly of any skeletal joint that is part of an appendage girdle region" [EMAPA:36914, UBERON:0008114]
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T11:00:47Z" xsd:dateTime

[Term]
id: MP:0030819
name: abnormal pelvic girdle joint morphology
def: "any structural anomaly of any synovial joint that is part of a pelvic girdle region" [UBERON:0011107]
synonym: "abnormal synovial joint of pelvic girdle morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030818 ! abnormal girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T11:12:28Z" xsd:dateTime

[Term]
id: MP:0030820
name: abnormal pectoral girdle joint morphology
def: "any structural anomaly of any synovial joint that is part of a pectoral girdle region" [UBERON:0011108]
synonym: "abnormal joint of shoulder girdle morphology" EXACT []
synonym: "abnormal synovial joint of pectoral girdle morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030818 ! abnormal girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T11:21:20Z" xsd:dateTime

[Term]
id: MP:0030821
name: abnormal sacroiliac joint morphology
def: "any structural anomaly of the synovial joint that forms between the lateral articulating surfaces of the sacrum and the articulating surfaces of the ilium; it is supported by a number of strong ligaments which increase joint stability and reduce the incidence of dislocations" [https://www.kenhub.com/en/library/anatomy/sacroiliac-joint, UBERON:0001365]
synonym: "abnormal sacro-iliac joint morphology" EXACT []
synonym: "abnormal SI joint morphology" EXACT []
is_a: MP:0030819 ! abnormal pelvic girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T11:51:52Z" xsd:dateTime

[Term]
id: MP:0030822
name: sacroiliac joint inflammation
def: "inflammation of one or both of the sacroiliac joints; it may be a symptom of other inflammatory arthritic conditions" [https://orcid.org/0000-0002-6490-7723, https://www.arthritis-health.com/types/general/sacroiliac-joint-pain-and-inflammation]
synonym: "sacroiliac arthritis" EXACT []
synonym: "sacroiliitis" EXACT []
synonym: "SI joint inflammation" EXACT []
is_a: MP:0002933 ! joint inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-09-26T11:58:32Z" xsd:dateTime

[Term]
id: MP:0030823
name: increased femur size
def: "greater than average size of the long bone of the thigh (femur)" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged femur" EXACT []
synonym: "increased femoral size" EXACT []
synonym: "large femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:13:26Z" xsd:dateTime

[Term]
id: MP:0030824
name: increased femur weight
def: "greater than average weight of the long bone of the thigh (femur)" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased femoral weight" EXACT []
is_a: MP:0030823 ! increased femur size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:19:56Z" xsd:dateTime

[Term]
id: MP:0030825
name: decreased femur size
def: "less than average size of the long bone of the thigh (femur)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased femoral size" EXACT []
synonym: "reduced femoral size" EXACT []
synonym: "reduced femur size" EXACT []
synonym: "small femur" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:28:28Z" xsd:dateTime

[Term]
id: MP:0030826
name: decreased femur weight
def: "less than average weight of the long bone of the thigh (femur)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased femoral weight" EXACT []
synonym: "reduced femoral weight" EXACT []
synonym: "reduced femur weight" EXACT []
is_a: MP:0030825 ! decreased femur size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:34:41Z" xsd:dateTime

[Term]
id: MP:0030827
name: femur fracture
def: "a crack or break in the long bone of the thigh (femur)" [https://orcid.org/0000-0002-6490-7723]
synonym: "femoral fracture" EXACT []
synonym: "femur fractures" EXACT []
is_a: MP:0000559 ! abnormal femur morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:43:28Z" xsd:dateTime

[Term]
id: MP:0030828
name: abnormal obturator foramen morphology
def: "any structural anomaly of the large opening created by the ischium and pubis bones of the pelvis through which nerves and blood vessels pass" [UBERON:0006803]
synonym: "abnormal foramen obturatorium morphology" EXACT []
synonym: "abnormal foramen obturatum morphology" RELATED []
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T09:59:25Z" xsd:dateTime

[Term]
id: MP:0030829
name: abnormal hip joint morphology
def: "any structural anomaly of the multi-axial, ball-and-socket synovial joint between the femur head and the acetabulum of the innominate bone" [https://en.wikipedia.org/wiki/Hip#Articulation, https://www.ncbi.nlm.nih.gov/books/NBK526019/, UBERON:0001486]
synonym: "abnormal acetabulo-femoral joint morphology" EXACT []
synonym: "abnormal acetabulofemoral joint morphology" EXACT []
synonym: "abnormal articulatio coxofemoralis morphology" EXACT []
synonym: "abnormal femoro-acetabular joint morphology" EXACT []
synonym: "abnormal femoro-iliac joint morphology" EXACT []
synonym: "abnormal femoroacetabular joint morphology" EXACT []
synonym: "abnormal femoroiliac joint morphology" EXACT []
is_a: MP:0030808 ! abnormal hindlimb joint morphology
is_a: MP:0030819 ! abnormal pelvic girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T10:19:53Z" xsd:dateTime

[Term]
id: MP:0030830
name: abnormal acetabulum morphology
def: "any structural anomaly of the large cup-shaped cavity on the anterolateral aspect of the pelvis that articulates with the femoral head to form the hip joint; it is formed by the three bones of the pelvis (the ischium, ilium and pubis) and is the socket portion of the ball-and-socket hip joint" [https://en.wikipedia.org/wiki/Acetabulum, https://radiopaedia.org/articles/acetabulum]
synonym: "abnormal acetabular cavity morphology" EXACT []
synonym: "abnormal acetabular region morphology" EXACT []
synonym: "abnormal acetabular socket morphology" EXACT []
synonym: "abnormal cotyloid cavity morphology" EXACT []
synonym: "abnormal hip socket morphology" EXACT []
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T10:53:48Z" xsd:dateTime

[Term]
id: MP:0030831
name: abnormal glenoid fossa morphology
def: "any structural anomaly of the shallow, pyriform articular surface located on the lateral angle of the scapula; it is directed laterally and forward and articulates with the head of the humerus" [HP:0011912, https://en.wikipedia.org/wiki/Glenoid_cavity]
synonym: "abnormal glenoid cavity morphology" EXACT []
synonym: "abnormal glenoid fossa of scapula morphology" EXACT []
is_a: MP:0000149 ! abnormal scapula morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T11:40:47Z" xsd:dateTime

[Term]
id: MP:0030832
name: abnormal scapular coracoid process morphology
def: "any structural anomaly of the hook-shaped bone structure that projects anterolaterally from the superior aspect of the scapular neck and serves as an important anchor for several tendinous and ligamentous structures" [https://pubs.rsna.org/doi/pdf/10.1148/rg.2016160039]
synonym: "abnormal coracoid process of scapula morphology" EXACT []
is_a: MP:0000149 ! abnormal scapula morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T11:54:55Z" xsd:dateTime

[Term]
id: MP:0030833
name: small acromion
def: "reduced size of the outer end of the spine of the scapula that protects the glenoid cavity, forms the outer angle of the shoulder, and articulates with the clavicle" [https://www.merriam-webster.com/medical/acromion]
synonym: "decreased acromion size" EXACT []
synonym: "reduced acromion size" EXACT []
synonym: "small acromial process" EXACT []
synonym: "small acromion process" EXACT []
is_a: MP:0004345 ! abnormal acromion morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T12:42:02Z" xsd:dateTime

[Term]
id: MP:0030834
name: acromion hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the acromion, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723, https://www.merriam-webster.com/medical/acromion]
synonym: "acromial process hypoplasia" EXACT []
synonym: "acromion process hypoplasia" EXACT []
synonym: "hypoplastic acromial process" EXACT []
synonym: "hypoplastic acromion" EXACT []
synonym: "hypoplastic acromion process" EXACT []
is_a: MP:0030833 ! small acromion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T12:47:25Z" xsd:dateTime

[Term]
id: MP:0030835
name: abnormal ankle joint morphology
def: "any structural anomaly of a joint that connects the hindlimb autopod and zeugopod skeletons" [UBERON:0001488]
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030808 ! abnormal hindlimb joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T12:54:17Z" xsd:dateTime

[Term]
id: MP:0030836
name: abnormal tibiofibular joint morphology
def: "any structural anomaly of a joint that connects the tibia and the fibula" [UBERON:0011112]
synonym: "abnormal fibulatibial joint morphology" EXACT []
synonym: "abnormal fibulotibial joint morphology" EXACT []
synonym: "abnormal tibiafibular joint morphology" EXACT []
is_a: MP:0003857 ! abnormal hindlimb zeugopod morphology
is_a: MP:0030808 ! abnormal hindlimb joint morphology
is_a: MP:0030879 ! abnormal syndesmosis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-01T13:09:23Z" xsd:dateTime

[Term]
id: MP:0030837
name: abnormal knee joint morphology
def: "any structural anomaly of the synovial hinge joint formed between the femur, tibia, and patella; it involves two articulations: the tibiofemoral joint, connecting the proximal tibia to the distal femur, and the patellofemoral joint, connecting the patella to the femur; the knee joint allows flexion and extension of the leg, as well as slight medial rotation in end extension, and lateral rotation when unlocking the knee" [https://www.kenhub.com/en/library/anatomy/the-knee-joint]
is_a: MP:0030804 ! abnormal synovial joint morphology
is_a: MP:0030808 ! abnormal hindlimb joint morphology
is_a: MP:0030881 ! abnormal knee morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-03T07:45:26Z" xsd:dateTime

[Term]
id: MP:0030838
name: abnormal acetabular fossa morphology
def: "any structural anomaly of the roughened depression in the acetabular floor which extends superiorly from the acetabular notch and hosts the ligamentum teres" [https://radiopaedia.org/articles/acetabulum]
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-03T08:17:17Z" xsd:dateTime

[Term]
id: MP:0030839
name: abnormal acetabular notch morphology
def: "any structural anomaly of the deep notch (depression) located anteroinferiorly along the margin of the acetabulum; it is bridged by the transverse ligament and thus forms the acetabular foramen through which nutrient vessels and nerves enter the hip joint; the ligamentum teres has part of its origin from the acetabular notch" [https://en.wikipedia.org/wiki/Acetabular_notch, https://radiopaedia.org/articles/acetabular-notch, UBERON:0014446]
is_a: MP:0004509 ! abnormal pelvic girdle bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-03T08:36:27Z" xsd:dateTime

[Term]
id: MP:0030840
name: abnormal acetabular labrum morphology
def: "any structural anomaly of the horse-shaped fibrocartilaginous structure that attaches to the peripheral rim of the acetabulum, contacts the articular surface of the femoral head, and blends inferiorly with the transverse acetabular ligament; it increases the depth of the acetabulum, increasing static stability and contributes to hydrostatic pressurization of the intra-articular space, joint lubrication, and load distribution" [https://books.google.com/books?isbn=0323549667]
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-03T09:12:31Z" xsd:dateTime

[Term]
id: MP:0030841
name: abnormal transverse acetabular ligament morphology
def: "any structural anomaly of the fibrous continuation of the acetabular labrum that is completely collagenous and contains no chondrocytes or cartilage; it consists of strong, flattened fibers which cross the acetabular notch and convert it into the acetabular foramen through which nutrient vessels and nerves enter the hip joint; it prevents inferior displacement of head of femur" [http://www.anatomyexpert.com/app/structure/15415/, https://en.wikipedia.org/wiki/Transverse_acetabular_ligament]
is_a: MP:0030829 ! abnormal hip joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-03T09:36:27Z" xsd:dateTime

[Term]
id: MP:0030842
name: absent subarcuate fossa
def: "missing the irregular depression normally found on the posterior inner surface of the petrous portion of the temporal bone just below its crest and above and lateral to the internal acoustic meatus" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "absent floccular fossa" EXACT []
is_a: MP:0009822 ! abnormal subarcuate fossa morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T10:31:54Z" xsd:dateTime

[Term]
id: MP:0030843
name: elbow dislocation
def: "dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet" [HP:0003042]
synonym: "dislocated elbow" EXACT []
synonym: "dislocated elbows" EXACT []
is_a: MP:0013945 ! abnormal elbow joint morphology
is_a: MP:0030795 ! joint dislocation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T10:54:51Z" xsd:dateTime

[Term]
id: MP:0030844
name: abnormal pubis body morphology
def: "any structural anomaly of the flattened medial portion of the pubic bone entering into the pubic symphysis; superior and inferior rami extend from it; the body forms one-fifth of the acetabulum, contributing by its external surface both to the lunate surface and the acetabular fossa; its internal surface enters into the formation of the wall of the lesser pelvis and gives origin to a portion of the obturator internus" [https://en.wikipedia.org/wiki/Pubis_(bone), https://medical-dictionary.thefreedictionary.com/body+of+pubis]
synonym: "abnormal pubic body morphology" EXACT []
synonym: "abnormal pubic bone body morphology" EXACT []
is_a: MP:0004506 ! abnormal pubis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:10:35Z" xsd:dateTime

[Term]
id: MP:0030845
name: abnormal pubic ramus morphology
def: "any structural anomaly of either of the two bar-like processes (branches or rami) of the pubic bone that extend laterally and posteriorly from the pubic symphysis; the inferior ramus articulates with the ischium; the superior ramus articulates with the ilium and forms the front of the acetabulum" [https://medical-dictionary.thefreedictionary.com/pubic+ramus]
is_a: MP:0004506 ! abnormal pubis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:24:22Z" xsd:dateTime

[Term]
id: MP:0030846
name: abnormal superior pubic ramus morphology
def: "any structural anomaly of the bar of bone, triangular in section, which extends posterosuperiorly from the body of the pubis to form the superior boundary of the obturator foramen; it contributes about one fifth of the articular surface of the acetabulum" [https://medical-dictionary.thefreedictionary.com/superior+pubic+ramus]
synonym: "abnormal superior branch of the pubic bone morphology" EXACT []
is_a: MP:0030845 ! abnormal pubic ramus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:30:56Z" xsd:dateTime

[Term]
id: MP:0030847
name: abnormal inferior pubic ramus morphology
def: "any structural anomaly of the inferior extension from body of pubic bone that meets with the ramus of the ischium below the obturator foramen to form the ischiopubic ramus" [https://medical-dictionary.thefreedictionary.com/inferior+pubic+ramus]
synonym: "abnormal inferior branch of the pubic bone morphology" EXACT []
is_a: MP:0030845 ! abnormal pubic ramus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:38:05Z" xsd:dateTime

[Term]
id: MP:0030848
name: short ilium
def: "reduced length of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased iliac bone length" EXACT []
synonym: "decreased ilium length" EXACT []
synonym: "reduced ilium length" EXACT []
synonym: "shortened ilium" EXACT []
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:53:29Z" xsd:dateTime

[Term]
id: MP:0030849
name: wide ilium
def: "increased width of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased iliac bone width" EXACT []
synonym: "increased ilium width" EXACT []
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T11:58:44Z" xsd:dateTime

[Term]
id: MP:0030850
name: abnormal ilium body morphology
def: "any structural anomaly of the thick lower part (base) of the ilium that forms about the upper two-fifths of the acetabulum; its external surface is partly articular, partly non-articular; the articular segment forms part of the lunate surface of the acetabulum, the non-articular portion contributes to the acetabular fossa; the internal surface of the body is part of the wall of the lesser pelvis and gives origin to some fibers of the obturator internus; below, it is continuous with the pelvic surfaces of the ischium and pubis, only a faint line indicating the place of union" [http://www.anatomyexpert.com/app/structure/127/833/, UBERON:0010747]
synonym: "abnormal iliac bone body morphology" EXACT []
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T12:03:10Z" xsd:dateTime

[Term]
id: MP:0030851
name: abnormal iliac fossa morphology
def: "any structural anomaly of the large, smooth, concave surface on the internal surface of the ilium; the fossa is bounded above by the iliac crest, below by the arcuate line, and in front and behind, by the anterior and posterior borders of the ilium; it gives origin to the iliacus muscle" [https://en.wikipedia.org/wiki/Iliac_fossa]
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T12:12:02Z" xsd:dateTime

[Term]
id: MP:0030852
name: abnormal ilium wing morphology
def: "any structural anomaly of the large, expanded (wing-like) portion of the ilium which bounds the greater pelvis laterally" [https://en.wikipedia.org/wiki/Wing_of_ilium, UBERON:0010746]
synonym: "abnormal iliac blade morphology" EXACT []
synonym: "abnormal ilium ala morphology" EXACT []
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T12:27:44Z" xsd:dateTime

[Term]
id: MP:0030853
name: abnormal iliac crest morphology
def: "any structural anomaly of the superior border of the wing of ilium and the superolateral margin of the greater pelvis; it runs from the anterior superior iliac spine to the posterior superior iliac spine; many of the important abdominal and core muscles are attached to the iliac crest" [https://en.wikipedia.org/wiki/Iliac_crest, https://www.verywellhealth.com/iliac-crest-definition-3120351]
is_a: MP:0005354 ! abnormal ilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T12:41:49Z" xsd:dateTime

[Term]
id: MP:0030854
name: atlanto-occipital joint dislocation
def: "separation of the joints formed by the occipital condyles and the atlas (C-1)" [https://thejns.org/doi/pdf/10.3171/2012.10.SPINE12430]
is_a: MP:0030795 ! joint dislocation
is_a: MP:0030810 ! abnormal atlanto-occipital joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-09T13:46:13Z" xsd:dateTime

[Term]
id: MP:0030855
name: abnormal olecranon fossa morphology
def: "any structural anomaly of the deep triangular depression on the posterior side of the humerus, superior to the trochlea, in which the summit of the olecranon is received during extension of the forearm" [https://en.wikipedia.org/wiki/Olecranon_fossa]
synonym: "abnormal fossa olecrani morphology" EXACT []
is_a: MP:0005296 ! abnormal humerus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T10:14:55Z" xsd:dateTime

[Term]
id: MP:0030856
name: abnormal olecranon morphology
def: "any structural anomaly of the large bony prominence at the proximal end of the ulna which articulates with the olecranon fossa of the humerus and is palpable at the posterior aspect of the elbow; while the olecranon is an attachment site for several muscle groups including the flexor carpi ulnaris and anconeus, the major muscle attachment is that of the triceps brachii muscle" [https://radiopaedia.org/articles/olecranon, https://www.medicinenet.com/script/main/art.asp?articlekey=9478, https://www.orthopaedicsone.com/display/MSKMed/Olecranon+fractures]
synonym: "abnormal elbow bony tip morphology" EXACT []
synonym: "abnormal olecranon process of ulna morphology" EXACT []
synonym: "abnormal ulnar process morphology" RELATED []
is_a: MP:0005108 ! abnormal ulna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T10:31:48Z" xsd:dateTime

[Term]
id: MP:0030857
name: absent olecranon
def: "missing the large bony prominence at the proximal end of the ulna which articulates with the olecranon fossa of the humerus and is palpable at the posterior aspect of the elbow" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent elbow bony tip" EXACT []
synonym: "absent olecranon process of ulna" EXACT []
synonym: "absent ulnar process" RELATED []
is_a: MP:0030856 ! abnormal olecranon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T10:39:39Z" xsd:dateTime

[Term]
id: MP:0030858
name: small olecranon
def: "size reduction of the large bony prominence at the proximal end of the ulna which articulates with the olecranon fossa of the humerus and is palpable at the posterior aspect of the elbow" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased olecranon size" EXACT []
synonym: "reduced olecranon process" RELATED []
synonym: "reduced olecranon size" EXACT []
synonym: "reduced ulnar process" RELATED []
synonym: "small elbow bony tip" EXACT []
synonym: "small olecranon process of ulna" EXACT []
is_a: MP:0030856 ! abnormal olecranon morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T10:42:34Z" xsd:dateTime

[Term]
id: MP:0030859
name: absent sesamoid bone of gastrocnemius
def: "missing the small sesamoid bones situated behind the condyles of the femur" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent fabella" EXACT []
synonym: "absent fabellae" EXACT []
synonym: "absent medial sesamoid bone of the knee" EXACT []
is_a: MP:0009005 ! abnormal sesamoid bone of gastrocnemius morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T10:51:51Z" xsd:dateTime

[Term]
id: MP:0030860
name: patellar dislocation
def: "complete displacement of the patella (kneecap) from its normal position in the patellofemoral groove (trochlea), the V-shaped notch on the front of the femur; the most common direction for a dislocated patella is lateral" [https://www.joionline.net/trending/content/what-recovery-time-dislocated-patella, https://www.stoneclinic.com/patelladislocation]
synonym: "dislocated kneecap" EXACT []
synonym: "dislocated patella" EXACT []
synonym: "dislocated patellae" EXACT []
synonym: "patellar luxation" EXACT []
is_a: MP:0005353 ! abnormal patella morphology
is_a: MP:0030795 ! joint dislocation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-10T12:35:57Z" xsd:dateTime

[Term]
id: MP:0030861
name: abnormal triquetrum morphology
def: "any structural anomaly of the bone in the proximal row of the carpus that has a pyramidal shape and that is situated between the lunate and pisiform bones" [https://www.merriam-webster.com/medical/triquetral%20bone]
synonym: "abnormal triangular bone morphology" EXACT []
synonym: "abnormal triquetral bone morphology" EXACT []
synonym: "abnormal ulnare morphology" EXACT []
is_a: MP:0000554 ! abnormal carpal bone morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T10:48:04Z" xsd:dateTime

[Term]
id: MP:0030862
name: absent triquetrum
def: "missing the bone in the proximal row of the carpus that has a pyramidal shape and that is situated between the lunate and pisiform bones" [https://orcid.org/0000-0002-6490-7723, https://www.merriam-webster.com/medical/triquetral%20bone]
synonym: "absent triangular bone" EXACT []
synonym: "absent triquetral bone" EXACT []
synonym: "absent ulnare" EXACT []
is_a: MP:0000555 ! absent carpal bone
is_a: MP:0030861 ! abnormal triquetrum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T10:56:16Z" xsd:dateTime

[Term]
id: MP:0030863
name: decreased joint mobility
def: "reduced ability to move joints in a full range of motion and with ease" [https://orcid.org/0000-0002-6490-7723]
synonym: "limited joint mobility" EXACT []
synonym: "reduced joint mobility" EXACT []
is_a: MP:0008069 ! abnormal joint mobility
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T11:14:04Z" xsd:dateTime

[Term]
id: MP:0030864
name: wrist dislocation
def: "displacement of any of the small carpal bones which make up the wrist out of their normal position in the wrist joint" [https://orcid.org/0000-0002-6490-7723]
synonym: "dislocated wrist" EXACT []
is_a: MP:0030795 ! joint dislocation
is_a: MP:0030814 ! abnormal wrist joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T11:25:14Z" xsd:dateTime

[Term]
id: MP:0030865
name: abnormal synovial joint cavity morphology
def: "any structural anomaly of the minute space enclosed by the synovial membrane and articular cartilages in a synovial joint; it is the site at which the articulating surfaces of the bones contact each other; it contains synovial fluid, a highly viscous, hyaluronic acid–rich fluid that lubricates the joint surfaces" [https://books.google.com/books?isbn=0803647204, https://opentextbc.ca/anatomyandphysiology/chapter/9-4-synovial-joints/, ISBN:978-0-323-07954-9]
synonym: "abnormal articular cavity morphology" EXACT []
synonym: "abnormal joint cavity morphology" EXACT []
synonym: "abnormal synovial cavity of joint morphology" EXACT []
synonym: "abnormal synovial space morphology" EXACT []
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T12:39:04Z" xsd:dateTime

[Term]
id: MP:0030866
name: abnormal synovial joint membrane morphology
def: "any structural anomaly of the connective tissue membrane that lines the cavity of a synovial joint and produces the synovial fluid; it lines all internal surfaces of the cavity except for the articular cartilage of the bones" [https://medical-dictionary.thefreedictionary.com/synovial+membrane, ISBN:978-0-323-07954-9, UBERON:0002018]
synonym: "abnormal stratum synoviale morphology" EXACT []
synonym: "abnormal synovial joint lining morphology" EXACT []
synonym: "abnormal synovial layer of articular capsule morphology" EXACT []
synonym: "abnormal synovial membrane morphology" BROAD []
synonym: "abnormal synovial membrane of synovial joint morphology" EXACT []
synonym: "abnormal synovium morphology" BROAD []
is_a: MP:0030804 ! abnormal synovial joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-15T12:51:55Z" xsd:dateTime

[Term]
id: MP:0030867
name: small thyroid cartilage
def: "size reduction of the largest of the laryngeal cartilages" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased thyroid cartilage size" EXACT []
synonym: "reduced thyroid cartilage size" EXACT []
is_a: MP:0002260 ! abnormal thyroid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T10:31:14Z" xsd:dateTime

[Term]
id: MP:0030868
name: absent thyroid cartilage
def: "missing the largest of the laryngeal cartilages" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002260 ! abnormal thyroid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T10:37:00Z" xsd:dateTime

[Term]
id: MP:0030869
name: thyroid cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the thyroid cartilage, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic thyroid cartilage" EXACT []
is_a: MP:0030867 ! small thyroid cartilage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T10:42:05Z" xsd:dateTime

[Term]
id: MP:0030870
name: abnormal superior horn of thyroid cartilage morphology
def: "any structural anomaly of either of a pair of upward projections from the posterior border of the thyroid cartilage; it is long and narrow, directed upward, backward, and medialward, and ends in a conical extremity, which gives attachment to the lateral hyothyroid ligament" [https://en.wikipedia.org/wiki/Thyroid_cartilage, UBERON:0011624]
synonym: "abnormal cornu superius cartilaginis thyroideae morphology" EXACT []
synonym: "abnormal superior cornu of thyroid cartilage morphology" EXACT []
synonym: "abnormal superior thyroid cartilage horn morphology" EXACT []
synonym: "abnormal upper thyroid cartilage horn morphology" EXACT []
is_a: MP:0002260 ! abnormal thyroid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T10:46:00Z" xsd:dateTime

[Term]
id: MP:0030871
name: abnormal inferior horn of thyroid cartilage morphology
def: "any structural anomaly of either of a pair of downward projections from the posterior border of the thyroid cartilage; it is short and thick, directed downward, with a slight inclination forward and medialward, and presents, on the medial side of its tip, a small oval articular facet for articulation with the side of the cricoid cartilage" [https://en.wikipedia.org/wiki/Thyroid_cartilage, UBERON:0011625]
synonym: "abnormal cornu inferius cartilaginis thyroideae morphology" EXACT []
synonym: "abnormal inferior cornu of thyroid cartilage morphology" EXACT []
is_a: MP:0002260 ! abnormal thyroid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:04:51Z" xsd:dateTime

[Term]
id: MP:0030872
name: small cricoid cartilage
def: "size reduction of the most inferior of the laryngeal cartilages" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cricoid cartilage size" EXACT []
synonym: "reduced cricoid cartilage size" EXACT []
is_a: MP:0002258 ! abnormal cricoid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:15:01Z" xsd:dateTime

[Term]
id: MP:0030873
name: absent cricoid cartilage
def: "missing the most inferior of the laryngeal cartilages" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002258 ! abnormal cricoid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:18:17Z" xsd:dateTime

[Term]
id: MP:0030874
name: cricoid cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the cricoid cartilage, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic cricoid cartilage" EXACT []
is_a: MP:0030872 ! small cricoid cartilage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:21:41Z" xsd:dateTime

[Term]
id: MP:0030875
name: abnormal cartilaginous joint morphology
def: "any structural anomaly of any joint that lacks a joint cavity and involves bones that are joined together by either hyaline cartilage or fibrocartilage; there are two main types: synchondroses (or primary cartilaginous joints) where the bones are united by hyaline cartilage, and symphyses (or secondary cartilaginous joints) where the bones are united by a layer of fibrocartilage" [https://opentextbc.ca/anatomyandphysiology/chapter/9-3-cartilaginous-joints/, https://teachmeanatomy.info/the-basics/joints-basic/classification-of-joints/]
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:32:38Z" xsd:dateTime

[Term]
id: MP:0030876
name: abnormal costochondral joint morphology
def: "any structural anomaly of the hyaline cartilaginous joint (synchondrosis) between each rib and its costal cartilage; the articulation is between the cup-shaped depression in the sternal end of a rib and the lateral end of a costal cartilage; the rib and its cartilage are firmly bound together by the continuity of the periosteum of the rib with the perichondrium of the cartilage; no movement normally occurs at these joints" [https://www.kenhub.com/en/library/anatomy/thoracic-cage, UBERON:0002293]
synonym: "abnormal chondrocostal synchondrosis" EXACT []
synonym: "abnormal costo-chondral junction morphology" EXACT []
synonym: "abnormal costochondral junction morphology" EXACT []
synonym: "abnormal costochondral synchondrosis" EXACT []
is_a: MP:0004053 ! abnormal synchondrosis
is_a: MP:0004625 ! abnormal rib joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T11:59:45Z" xsd:dateTime

[Term]
id: MP:0030877
name: abnormal symphysis morphology
def: "any structural anomaly of any cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage; a symphysis is a slightly movable joint (amphiarthrosis)" [https://en.wikipedia.org/wiki/Symphysis, UBERON:0002216]
synonym: "abnormal secondary cartilaginous joint morphology" EXACT []
is_a: MP:0030875 ! abnormal cartilaginous joint morphology
is_a: MP:0030878 ! abnormal fibrous joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T12:20:07Z" xsd:dateTime

[Term]
id: MP:0030878
name: abnormal fibrous joint morphology
def: "any structural anomaly of any joint that lacks a joint cavity and involves bones that are joined together by dense fibrous connective tissue, consisting mainly of collagen; most (but not all) fibrous joints are immovable (synarthroses)" [https://en.wikipedia.org/wiki/Fibrous_joint, https://www.visiblebody.com/learn/skeleton/joints-and-ligaments]
is_a: MP:0002932 ! abnormal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T12:49:17Z" xsd:dateTime

[Term]
id: MP:0030879
name: abnormal syndesmosis morphology
def: "any structural anomaly of any fibrous joint where the gap between two adjacent bones may be narrow, with the bones joined by ligaments, or the gap may be wide and filled in by a broad sheet of connective tissue called an interosseous membrane; syndemoses are slightly moveable (amphiarthrodial)" [https://en.wikipedia.org/wiki/Fibrous_joint, https://opentextbc.ca/anatomyandphysiology/chapter/9-2-fibrous-joints/]
synonym: "abnormal syndesmodial joint morphology" EXACT []
synonym: "abnormal syndesmotic joint morphology" EXACT []
is_a: MP:0030878 ! abnormal fibrous joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-17T13:03:59Z" xsd:dateTime

[Term]
id: MP:0030880
name: abnormal infrapatellar fat pad morphology
def: "any structural anomaly of the partly adipose wedge-shaped mass formed in the anterior region of the knee that is intracapsular but extrasynovial (and thus extra-articular); it extends superiorly from the patella and alar folds to the tibia and infrapatellar bursa and is delimited anteriorly by the patellar ligament and joint capsule and posteriorly by the synovial membrane" [PMID:25018130]
synonym: "abnormal Hoffa fat pad morphology" EXACT []
is_a: MP:0005334 ! abnormal fat pad morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T10:38:06Z" xsd:dateTime

[Term]
id: MP:0030881
name: abnormal knee morphology
def: "any structural anomaly of the segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod" [UBERON:0001465]
synonym: "abnormal knee region morphology" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T10:50:54Z" xsd:dateTime

[Term]
id: MP:0030882
name: abnormal radius head morphology
def: "any structural anomaly of the proximal articular surface of the radius that forms part of the elbow joint and that is palpable on the lateral side of the elbow, immediately distal to the lateral epicondyle of the humerus; the radial head articulates with the ulna at the proximal radioulnar joint and with the humerus at the radiohumeral joint; at the proximal radioulnar joint, the radial head sits in the radial notch of the proximal ulna and is held in place by the annular ligaments; at the radiohumeral joint, the radial head sits adjacent to the capitellum of the humerus" [https://radiopaedia.org/articles/radial-head]
synonym: "abnormal caput radii morphology" EXACT []
synonym: "abnormal head of radius morphology" EXACT []
synonym: "abnormal radial head morphology" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
is_a: MP:0013945 ! abnormal elbow joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T11:18:01Z" xsd:dateTime

[Term]
id: MP:0030883
name: dislocated radius head
def: "a dislocation of the head of the radius from its socket in the elbow joint" [HP:0003083]
synonym: "dislocated radial head" EXACT []
synonym: "radial head dislocation" EXACT []
synonym: "radius head dislocation" EXACT []
is_a: MP:0030843 ! elbow dislocation
is_a: MP:0030882 ! abnormal radius head morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T11:29:17Z" xsd:dateTime

[Term]
id: MP:0030884
name: rachitic rosary
def: "abnormal expansion of the anterior rib ends at the costochondral junctions; most frequently seen in rickets as nodularity (prominent bony knobs) at the costochondral junctions" [https://radiopaedia.org/articles/rachitic-rosary]
synonym: "beaded ribs" EXACT []
synonym: "beading of the ribs" EXACT []
synonym: "rib beading" EXACT []
is_a: MP:0030876 ! abnormal costochondral joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T11:47:49Z" xsd:dateTime

[Term]
id: MP:0030885
name: increased radius size
def: "greater than average size of the short bone of the lateral forearm" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged radius" EXACT []
synonym: "increased radius bone size" EXACT []
synonym: "large radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T12:30:59Z" xsd:dateTime

[Term]
id: MP:0030886
name: decreased radius size
def: "less than average size of the short bone of the lateral forearm" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased radius bone size" EXACT []
synonym: "reduced radius bone size" EXACT []
synonym: "reduced radius size" EXACT []
synonym: "small radius" EXACT []
is_a: MP:0000552 ! abnormal radius morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-19T12:34:58Z" xsd:dateTime

[Term]
id: MP:0030887
name: abnormal sternoclavicular joint morphology
def: "any structural anomaly of the synovial joint between the clavicle and the manubrium of the sternum; it is the only attachment of the upper limb to the axial skeleton and consists of the sternal end of the clavicle, the manubrium of the sternum, and part of the first costal cartilage; the articular surfaces are covered with fibrocartilage (as opposed to hyaline cartilage); the joint is separated into two compartments by a fibrocartilaginous articular disk" [https://teachmeanatomy.info/upper-limb/joints/sternoclavicular/]
synonym: "abnormal sterno-clavicular joint morphology" EXACT []
synonym: "abnormal sternoclavicular articulation morphology" EXACT []
is_a: MP:0030820 ! abnormal pectoral girdle joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T10:31:51Z" xsd:dateTime

[Term]
id: MP:0030888
name: absent arytenoid cartilage
def: "missing the paired triangular cartilages that normally are located postlaterally at the level of the thyroid cartilage" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002257 ! abnormal arytenoid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T10:47:41Z" xsd:dateTime

[Term]
id: MP:0030889
name: small arytenoid cartilage
def: "size reduction of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased arytenoid cartilage size" EXACT []
synonym: "reduced arytenoid cartilage size" EXACT []
is_a: MP:0002257 ! abnormal arytenoid cartilage morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T10:52:30Z" xsd:dateTime

[Term]
id: MP:0030890
name: arytenoid cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the arytenoid cartilage, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic arytenoid cartilage" EXACT []
is_a: MP:0030889 ! small arytenoid cartilage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T10:55:41Z" xsd:dateTime

[Term]
id: MP:0030891
name: small epiglottis
def: "size reduction of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased epiglottis size" EXACT []
synonym: "reduced epiglottis size" EXACT []
is_a: MP:0010371 ! abnormal epiglottis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T11:02:23Z" xsd:dateTime

[Term]
id: MP:0030892
name: epiglottis hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the epiglottis, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic epiglottis" EXACT []
is_a: MP:0030891 ! small epiglottis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T11:06:13Z" xsd:dateTime

[Term]
id: MP:0030893
name: enlarged epiglottis
def: "increased size of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased epiglottis size" EXACT []
synonym: "large epiglottis" EXACT []
is_a: MP:0010371 ! abnormal epiglottis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T11:16:22Z" xsd:dateTime

[Term]
id: MP:0030894
name: epiglottis hyperplasia
def: "increase in the number of normal cells in normal arrangement in the epiglottis, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic epiglottis" EXACT []
is_a: MP:0030893 ! enlarged epiglottis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T11:19:16Z" xsd:dateTime

[Term]
id: MP:0030895
name: abnormal tibiofemoral joint morphology
def: "any structural anomaly of the modified hinge synovial joint that joins the distal femur to the proximal tibia; it is the weight-bearing joint of the knee; the articulation occurs between the medial and lateral femoral condyles and the tibial condyles" [https://radiopaedia.org/articles/tibiofemoral-joint, https://teachmeanatomy.info/lower-limb/joints/the-knee-joint/]
synonym: "abnormal femoro-tibial joint morphology" EXACT []
synonym: "abnormal femorotibial joint morphology" EXACT []
synonym: "abnormal femuro-tibial joint morphology" EXACT []
is_a: MP:0030837 ! abnormal knee joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T11:33:42Z" xsd:dateTime

[Term]
id: MP:0030896
name: abnormal patellofemoral joint morphology
def: "any structural anomaly of the synovial joint between the condyles of the femur and the articular surface of the patella" [https://radiopaedia.org/articles/patellofemoral-joint]
synonym: "abnormal femoro-patellar joint morphology" EXACT []
synonym: "abnormal femoropatellar joint morphology" EXACT []
synonym: "abnormal patello-femoral joint morphology" EXACT []
is_a: MP:0030837 ! abnormal knee joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T12:02:28Z" xsd:dateTime

[Term]
id: MP:0030897
name: abnormal humeroulnar joint morphology
def: "any structural anomaly of the simple hinge-type synovial joint between the trochlea on the medial aspect of the distal end of the humerus and the trochlear notch on the proximal ulna" [https://www.kenhub.com/en/library/anatomy/elbow-joint]
synonym: "abnormal articulatio humeroulnaris morphology" EXACT []
synonym: "abnormal humero-ulnar joint morphology" EXACT []
synonym: "abnormal ulno-humeral joint morphology" EXACT []
synonym: "abnormal ulnohumeral joint morphology" EXACT []
is_a: MP:0013945 ! abnormal elbow joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T12:26:26Z" xsd:dateTime

[Term]
id: MP:0030898
name: abnormal first sternocostal joint morphology
def: "any structural anomaly of the synchondrosis type of cartilaginous joint in which hyaline cartilage unites the first rib to the manubrium of the sternum.; it forms an immobile joint (synarthrosis); the rest of the sternocostal joints are synovial plane joints" [http://oerpub.github.io/epubjs-demo-book/content/m46381.xhtml, https://courses.lumenlearning.com/boundless-ap/chapter/cartilaginous-joints/]
synonym: "abnormal first sterno-costal joint morphology" EXACT []
synonym: "abnormal fist rib-sternum attachment" EXACT []
is_a: MP:0004053 ! abnormal synchondrosis
is_a: MP:0008148 ! abnormal sternocostal joint morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T12:41:26Z" xsd:dateTime

[Term]
id: MP:0030899
name: laryngeal cleft
def: "presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esopahagus" [HP:0008751]
synonym: "laryngotracheal cleft" EXACT []
synonym: "laryngotracheoesophageal cleft" EXACT []
is_a: MP:0002249 ! abnormal larynx morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-10-24T13:08:22Z" xsd:dateTime

[Term]
id: MP:0030900
name: decreased ulna size
def: "less than average size of the medial and larger of the two bones of the forearm" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced ulna size" EXACT []
synonym: "small ulna" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T08:33:04Z" xsd:dateTime

[Term]
id: MP:0030901
name: increased ulna size
def: "greater than average size of the medial and larger of the two bones of the forearm" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged ulna" EXACT []
synonym: "large ulna" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T08:45:01Z" xsd:dateTime

[Term]
id: MP:0030902
name: abnormal ulnar styloid process morphology
def: "any structural anomaly of the cylindrical, pointed, palpable projection from the medial and posterior aspect of the head of the ulna, to the tip of which is attached the ulnar collateral ligament of the wrist" [https://medical-dictionary.thefreedictionary.com/styloid+process]
synonym: "abnormal styloid process of ulna morphology" EXACT []
is_a: MP:0005108 ! abnormal ulna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T09:03:50Z" xsd:dateTime

[Term]
id: MP:0030903
name: small ulnar styloid process
def: "reduced size of the cylindric, pointed, palpable projection from the medial and posterior aspect of the head of the ulna, to the tip of which is attached the ulnar collateral ligament of the wrist" [https://medical-dictionary.thefreedictionary.com/styloid+process, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased size of ulnar styloid process" EXACT []
synonym: "reduced size of ulnar styloid process" EXACT []
is_a: MP:0030902 ! abnormal ulnar styloid process morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T09:34:36Z" xsd:dateTime

[Term]
id: MP:0030904
name: abnormal melanoblast physiology
def: "any functional anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0012745 ! abnormal neural crest cell physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T16:01:35Z" xsd:dateTime

[Term]
id: MP:0030905
name: abnormal melanoblast proliferation
def: "anomaly in the ability of melanoblasts to undergo expansion by cell division; a melanoblast is a cell that originates from the neural crest and differentiates into a pigment cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0030904 ! abnormal melanoblast physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T16:09:08Z" xsd:dateTime

[Term]
id: MP:0030906
name: decreased melanoblast proliferation
def: "reduction in the expansion rate of melanoblasts by cell division; a melanoblast is a cell that originates from the neural crest and differentiates into a pigment cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced melanoblast proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0030905 ! abnormal melanoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T16:15:17Z" xsd:dateTime

[Term]
id: MP:0030907
name: increased melanoblast proliferation
def: "increase in the expansion rate of melanoblasts by cell division; a melanoblast is a cell that originates from the neural crest and differentiates into a pigment cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0030905 ! abnormal melanoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-16T16:19:59Z" xsd:dateTime

[Term]
id: MP:0030908
name: abnormal melanocyte differentiation
def: "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a melanocyte" [GO:0030318]
synonym: "abnormal melanocyte cell differentiation" EXACT []
is_a: MP:0002877 ! abnormal melanocyte morphology
is_a: MP:0005076 ! abnormal cell differentiation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T08:26:35Z" xsd:dateTime

[Term]
id: MP:0030909
name: abnormal melanocyte adhesion
def: "any anomaly in the adhesive properties of melanocytes, resulting in abnormal cell to cell and cell to extracellular matrix (ECM) interactions" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0003566 ! abnormal cell adhesion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T09:57:46Z" xsd:dateTime

[Term]
id: MP:0030910
name: abnormal melanoblast apoptosis
def: "change in the timing or the number of melanoblasts undergoing programmed cell death; a melanoblast is a cell that originates from the neural crest and differentiates into a pigment cell" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0030904 ! abnormal melanoblast physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T10:13:23Z" xsd:dateTime

[Term]
id: MP:0030911
name: increased melanoblast apoptosis
def: "increase in the number of melanoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0030910 ! abnormal melanoblast apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T10:30:34Z" xsd:dateTime

[Term]
id: MP:0030912
name: decreased melanoblast apoptosis
def: "reduction in the number of melanoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced melanoblast apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0030910 ! abnormal melanoblast apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T10:33:39Z" xsd:dateTime

[Term]
id: MP:0030913
name: abnormal melanosome formation
def: "any anomaly in the aggregation, arrangement or bonding together of a set of components required to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored" [GO:1903232]
synonym: "abnormal melanosome assembly" EXACT []
is_a: MP:0005075 ! abnormal melanosome morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T12:50:36Z" xsd:dateTime

[Term]
id: MP:0030914
name: abnormal endosome to melanosome transport
def: "any anomaly in the directed movement of substances from endosomes to the melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored" [GO:0035646, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001186 ! pigmentation phenotype
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T13:27:29Z" xsd:dateTime

[Term]
id: MP:0030915
name: abnormal melanosome maturation
def: "any anomaly in the developmental processes that are required for a melanosome to attain its fully functional state; melanosome maturation occurs through sequential stages (I-IV) that can be defined based on morphology and melanin content; stage I pre-melanosomes are roughly spherical, lack pigment, contain intraluminal vesicles, and resemble multivesicular bodies i.e. structures found along the endosomal pathway; stage II melanosomes are elongated (ellipsoidal) in shape, lack pigment, and contain intraluminal matrix fibers organized in a striated array; deposition of melanin along the matrix fibers begins in stage III melanosomes; stage IV melanosomes, corresponding to fully-melanized mature organelles, are characterized by a dense homogeneous deposit of melanin that covers all the internal structures of the matrix" [https://books.google.gr/books?isbn=0080911951, PMID:12445206, PMID:16303920]
is_a: MP:0005075 ! abnormal melanosome morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T13:55:56Z" xsd:dateTime

[Term]
id: MP:0030916
name: abnormal melanosome size
def: "anomaly in the average size of the tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005075 ! abnormal melanosome morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:10:13Z" xsd:dateTime

[Term]
id: MP:0030917
name: enlarged melanosome
def: "greater than average size of the tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored; giant melanosomes may become frequent in conditions of pathological melanogenesis" [https://orcid.org/0000-0002-6490-7723, PMID:24485836]
synonym: "enlarged melanosomes" EXACT []
synonym: "giant melanosomes" EXACT []
synonym: "increased melanosome size" EXACT []
synonym: "large melanosomes" EXACT []
synonym: "macromelanosomes" EXACT []
synonym: "oversized melanosomes" EXACT []
is_a: MP:0030916 ! abnormal melanosome size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:18:23Z" xsd:dateTime

[Term]
id: MP:0030918
name: small melanosome
def: "less than average size of the tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased melanosome size" EXACT []
synonym: "micromelanosome" EXACT []
synonym: "reduced melanosome size" EXACT []
synonym: "small melanosomes" EXACT []
is_a: MP:0030916 ! abnormal melanosome size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:30:52Z" xsd:dateTime

[Term]
id: MP:0030919
name: absent hair follicle bulb
def: "missing the thickening of the proximal end of the hair follicle that contains rapidly proliferating, rather undifferentiated matrix cells (transient amplifying cells), melanocytes and outer root sheath cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent hair bulb" EXACT []
is_a: MP:0010681 ! abnormal hair follicle bulb morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:41:48Z" xsd:dateTime

[Term]
id: MP:0030920
name: small hair follicle bulb
def: "reduced size of the thickening of the proximal end of the hair follicle that contains rapidly proliferating, rather undifferentiated matrix cells (transient amplifying cells), melanocytes and outer root sheath cells" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased hair follicle bulb size" EXACT []
synonym: "reduced hair follicle bulb size" EXACT []
synonym: "small hair bulb" EXACT []
is_a: MP:0010681 ! abnormal hair follicle bulb morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:48:05Z" xsd:dateTime

[Term]
id: MP:0030921
name: abnormal hair club morphology
def: "any structural anomaly of the club-shaped structure which forms from keratinized epithelial cells at the base of the hair shaft during catagen, and interdigitates with the surrounding outer root sheath to anchor the hair in place; the club is necessary for the retention of a completed hair" [PMID:22611050]
is_a: MP:0003809 ! abnormal hair shaft morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T14:57:41Z" xsd:dateTime

[Term]
id: MP:0030922
name: absent hair club
def: "missing the club-shaped structure which forms from keratinized epithelial cells at the base of the hair shaft during catagen, and interdigitates with the surrounding outer root sheath to anchor the hair in place; the club is necessary for the retention of a completed hair" [https://orcid.org/0000-0002-6490-7723, PMID:22611050]
is_a: MP:0030921 ! abnormal hair club morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T15:03:13Z" xsd:dateTime

[Term]
id: MP:0030923
name: abnormal hair follicle ostium morphology
def: "any structural anomaly of any of the openings of the hair follicles through which the hair fibers emerge from the skin" [http://www.keratin.com/at/at003.shtml]
synonym: "abnormal follicular ostia morphology" EXACT []
synonym: "abnormal hair follicle ostia morphology" EXACT []
is_a: MP:0000377 ! abnormal hair follicle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-19T15:27:55Z" xsd:dateTime

[Term]
id: MP:0030924
name: early exit from telogen phase
def: "anomaly in the resting or quiescent phase of the hair growth cycle resulting a shortened telogen phase" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased telogen phase duration" EXACT []
synonym: "precocious exit from telogen" EXACT []
synonym: "premature end of telogen" EXACT []
synonym: "short telogen" EXACT []
synonym: "shortened telogen phase" EXACT []
is_a: MP:0008860 ! abnormal hair cycle telogen phase
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-23T12:24:06Z" xsd:dateTime

[Term]
id: MP:0030925
name: early exit from anagen phase
def: "anomaly in the growth phase of the hair cycle resulting a shortened anagen phase" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased anagen phase duration" EXACT []
synonym: "precocious exit from anagen" EXACT []
synonym: "premature end of anagen" EXACT []
synonym: "short anagen" EXACT []
synonym: "shortened anagen phase" EXACT []
is_a: MP:0008858 ! abnormal hair cycle anagen phase
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-11-23T12:40:44Z" xsd:dateTime

[Term]
id: MP:0030926
name: increased skin pigmentation
def: "visually detectable excess of pigment present in the skin" [https://orcid.org/0000-0002-6490-7723]
synonym: "cutaneous hyperpigmentation" EXACT []
synonym: "darkened skin" EXACT []
synonym: "darkening of the skin" EXACT []
synonym: "skin hyperpigmentation" EXACT []
is_a: MP:0001188 ! hyperpigmentation
is_a: MP:0002095 ! abnormal skin pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T10:01:56Z" xsd:dateTime

[Term]
id: MP:0030927
name: decreased telomere length
def: "reduction in the average length of the terminal repetitive DNA section of a chromosome that is involved in chromosomal replication and senescence and protects the end of the chromosome from deterioration; normal length is a few hundred base pairs" [https://orcid.org/0000-0002-6490-7723]
synonym: "short telomeres" EXACT []
synonym: "shortened telomeres" EXACT []
synonym: "telomere shortening" EXACT []
is_a: MP:0003155 ! abnormal telomere length
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T10:26:35Z" xsd:dateTime

[Term]
id: MP:0030928
name: increased telomere length
def: "increase in the average length of the terminal repetitive DNA section of a chromosome that is involved in chromosomal replication and senescence and protects the end of the chromosome from deterioration; normal length is a few hundred base pairs" [https://orcid.org/0000-0002-6490-7723]
synonym: "elongated telomeres" EXACT []
synonym: "telomere elongation" EXACT []
is_a: MP:0003155 ! abnormal telomere length
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T10:32:56Z" xsd:dateTime

[Term]
id: MP:0030929
name: increased digit pigmentation
def: "visually detectable excess of pigment present on the finger or toe surface" [https://orcid.org/0000-0002-6490-7723]
synonym: "dark toes" EXACT []
synonym: "digit hyperpigmentation" EXACT []
synonym: "finger hyperpigmentation" EXACT []
synonym: "hyperpigmented digits" EXACT []
synonym: "hyperpigmented toes" EXACT []
synonym: "increased finger pigmentation" EXACT []
synonym: "increased toe pigmentation" EXACT []
synonym: "toe hyperpigmentation" EXACT []
is_a: MP:0000569 ! abnormal digit pigmentation
is_a: MP:0030926 ! increased skin pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T11:17:02Z" xsd:dateTime

[Term]
id: MP:0030930
name: decreased digit pigmentation
def: "visually detectable dilution of pigment present on the finger or toe surface" [https://orcid.org/0000-0002-6490-7723]
synonym: "digit hypopigmentation" EXACT []
synonym: "finger hypopigmentation" EXACT []
synonym: "hypopigmented digits" EXACT []
synonym: "hypopigmented toes" EXACT []
synonym: "reduced digit pigmentation" EXACT []
synonym: "toe hypopigmentation" EXACT []
synonym: "white hind toes" NARROW []
synonym: "white toes" NARROW []
is_a: MP:0000569 ! abnormal digit pigmentation
is_a: MP:0011627 ! decreased skin pigmentation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T11:30:29Z" xsd:dateTime

[Term]
id: MP:0030931
name: increased nipple pigmentation
def: "visually detectable excess of pigment present on the surface of the nipple and/or areola" [https://orcid.org/0000-0002-6490-7723]
synonym: "darkened nipples" EXACT []
synonym: "hyperpigmented nipples" EXACT []
synonym: "nipple hyperpigmentation" EXACT []
is_a: MP:0001188 ! hyperpigmentation
is_a: MP:0006078 ! abnormal nipple morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2018-12-13T12:39:13Z" xsd:dateTime

[Term]
id: MP:0030932
name: hypopyon
def: "an accumulation of pus or white blood cells in the anterior chamber of the eye, appearing as a whitish or gray fluid between the cornea and the iris" [https://medical-dictionary.thefreedictionary.com/hypopyon]
is_a: MP:0001851 ! eye inflammation
is_a: MP:0005205 ! abnormal eye anterior chamber morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-03-26T10:29:35Z" xsd:dateTime

[Term]
id: MP:0030933
name: hyphema
def: "hemorrhage within the anterior chamber of the eye" [HP:0011886]
synonym: "hyphaema" EXACT []
synonym: "hyphaemia" RELATED [https://medical-dictionary.thefreedictionary.com/hyphemia]
synonym: "hyphemia" RELATED []
is_a: MP:0006203 ! eye hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-03-26T10:54:36Z" xsd:dateTime

[Term]
id: MP:0030934
name: decreased primordial germ cell proliferation
def: "reduced ability of a primordial germ cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased PGC proliferation" EXACT []
synonym: "reduced PGC proliferation" EXACT []
synonym: "reduced primordial germ cell proliferation" EXACT []
is_a: MP:0008390 ! abnormal primordial germ cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-03-26T11:38:35Z" xsd:dateTime

[Term]
id: MP:0030935
name: increased primordial germ cell apoptosis
def: "increase in the number of primordial germ cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased PGC apoptosis" EXACT []
is_a: MP:0011610 ! abnormal primordial germ cell apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-03-26T11:59:40Z" xsd:dateTime

[Term]
id: MP:0030937
name: increased mitochondrial DNA content
def: "greater than expected amount of DNA contained within the mitochondria of a mammalian cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased mitochondrial DNA level" EXACT []
synonym: "increased mitochondrial genome size" EXACT []
synonym: "increased mtDNA amount" EXACT []
synonym: "increased mtDNA content" EXACT []
is_a: MP:0011638 ! abnormal mitochondrial chromosome morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T10:29:29Z" xsd:dateTime

[Term]
id: MP:0030938
name: abnormal reticulophagy
def: "any anomaly in the selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions" [GO:0061709]
synonym: "abnormal autophagy of the endoplasmic reticulum" EXACT []
synonym: "abnormal autophagy of the ER" EXACT []
synonym: "abnormal ER-phagy" EXACT []
is_a: MP:0008260 ! abnormal autophagy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T10:42:24Z" xsd:dateTime

[Term]
id: MP:0030939
name: abnormal autophagosome formation
def: "any anomaly in the formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm" [GO:0000045]
synonym: "abnormal autophagic vacuole assembly" EXACT []
synonym: "abnormal autophagic vacuole formation" EXACT []
synonym: "abnormal autophagosome assembly" EXACT []
synonym: "abnormal autophagosome biosynthesis" EXACT []
is_a: MP:0008260 ! abnormal autophagy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T11:01:52Z" xsd:dateTime

[Term]
id: MP:0030940
name: impaired autophagy
def: "impairment of the catabolic process involving the degradation of a cell's own components through the lysosomal machinery" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased autophagy" EXACT []
synonym: "impaired autophagocytosis" EXACT []
synonym: "reduced autophagy" EXACT []
is_a: MP:0008260 ! abnormal autophagy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T11:20:17Z" xsd:dateTime

[Term]
id: MP:0030941
name: enhanced autophagy
def: "enhancement of the catabolic process involving the degradation of a cell's own components through the lysosomal machinery" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated autophagy" EXACT []
synonym: "enhanced autophagocytosis" EXACT []
synonym: "increased autophagy" EXACT []
is_a: MP:0008260 ! abnormal autophagy
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T11:27:40Z" xsd:dateTime

[Term]
id: MP:0030942
name: abnormal microtubule organizing center morphology
def: "any anomaly of the intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides" [GO:0005815]
synonym: "abnormal microtubule organising centre morphology" EXACT []
synonym: "abnormal MTOC morphology" EXACT []
is_a: MP:0020850 ! abnormal microtubule cytoskeleton morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T11:47:46Z" xsd:dateTime

[Term]
id: MP:0030943
name: abnormal centrosome morphology
def: "any structural anomaly of the non-membrane-bound organelle comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized; centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle" [GO:0005813]
is_a: MP:0030942 ! abnormal microtubule organizing center morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T11:58:03Z" xsd:dateTime

[Term]
id: MP:0030944
name: abnormal pericentriolar material morphology
def: "any structural anomaly of the network of small fibers that surrounds the centrioles; it contains the microtubule nucleating activity of the centrosome" [GO:0000242]
synonym: "abnormal PCM morphology" EXACT []
synonym: "abnormal pericentriolar matrix morphology" EXACT []
is_a: MP:0030943 ! abnormal centrosome morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-24T12:03:47Z" xsd:dateTime

[Term]
id: MP:0030945
name: abnormal myoblast migration
def: "any anomaly in the orderly movement of a myoblast from one site to another during development; a myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0051451]
synonym: "abnormal myoblast cell migration" EXACT []
is_a: MP:0003090 ! abnormal muscle precursor cell migration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T09:54:10Z" xsd:dateTime

[Term]
id: MP:0030946
name: abnormal myoblast proliferation
def: "anomaly in the ability of myoblasts to undergo expansion by cell division; a myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0051450, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal myoblast cell proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0000729 ! abnormal myogenesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T10:45:10Z" xsd:dateTime

[Term]
id: MP:0030947
name: increased myoblast proliferation
def: "increase in the expansion rate of myoblasts by cell division; a myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced myoblast cell proliferation" EXACT []
synonym: "increased myoblast cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0030946 ! abnormal myoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T10:55:21Z" xsd:dateTime

[Term]
id: MP:0030948
name: decreased myoblast proliferation
def: "reduction in the expansion rate of myoblasts by cell division; a myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased myoblast cell proliferation" EXACT []
synonym: "reduced myoblast cell proliferation" EXACT []
synonym: "reduced myoblast proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0030946 ! abnormal myoblast proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T11:00:58Z" xsd:dateTime

[Term]
id: MP:0030949
name: abnormal Golgi vesicle transport
def: "any anomaly in the directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles" [GO:0048193, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi-derived vesicle transport" RELATED []
is_a: MP:0008546 ! abnormal vesicle-mediated transport
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T11:36:32Z" xsd:dateTime

[Term]
id: MP:0030950
name: abnormal synaptic vesicle exocytosis
def: "anomaly in the fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in impaired release of neurotransmitter into the synaptic cleft" [GO:0016079, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005445 ! abnormal neurotransmitter secretion
is_a: MP:0020848 ! abnormal exocytosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T11:50:17Z" xsd:dateTime

[Term]
id: MP:0030951
name: abnormal endocytosis
def: "any anomaly in the vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle" [GO:0006897, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal endocytic import into cell" EXACT []
synonym: "abnormal nonselective vesicle endocytosis" RELATED []
synonym: "abnormal plasma membrane invagination" NARROW []
synonym: "abnormal vesicle endocytosis" EXACT []
is_a: MP:0008546 ! abnormal vesicle-mediated transport
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T11:58:42Z" xsd:dateTime

[Term]
id: MP:0030952
name: abnormal Golgi stack morphology
def: "any structural anomaly of the set of thin, flattened membrane-bounded compartments, called cisternae, which form the central portion of the Golgi complex; the stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack" [GO:0005795, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi cisternae" EXACT []
is_a: MP:0011743 ! abnormal Golgi apparatus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T12:08:06Z" xsd:dateTime

[Term]
id: MP:0030953
name: abnormal Golgi cisterna morphology
def: "any structural anomaly of any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex" [GO:0031985, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi cistern morphology" EXACT []
is_a: MP:0030952 ! abnormal Golgi stack morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T12:23:39Z" xsd:dateTime

[Term]
id: MP:0030954
name: abnormal Golgi cis cisterna morphology
def: "any structural anomaly of the Golgi cisterna closest to the endoplasmic reticulum (ER), the first processing compartment through which proteins pass after export from the ER" [GO:0000137, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi cis cistern morphology" EXACT []
is_a: MP:0030953 ! abnormal Golgi cisterna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T12:28:22Z" xsd:dateTime

[Term]
id: MP:0030955
name: abnormal Golgi trans cisterna morphology
def: "any structural anomaly of the Golgi cisterna farthest from the endoplasmic reticulum, the final processing compartment through which proteins pass before exiting the Golgi apparatus; this is the compartment in which N-linked protein glycosylation is completed" [GO:0000138, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal Golgi trans cistern morphology" EXACT []
is_a: MP:0030953 ! abnormal Golgi cisterna morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T12:39:17Z" xsd:dateTime

[Term]
id: MP:0030956
name: abnormal neuronal precursor cell migration
def: "any anomaly in the orderly movement of a neuroblast embryonic cell from one site to another during development" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal neuroblast cell migration" EXACT []
synonym: "abnormal neuroblast migration" EXACT []
synonym: "abnormal neuronal progenitor cell migration" EXACT []
is_a: MP:0006009 ! abnormal neuronal migration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-06-26T12:53:10Z" xsd:dateTime

[Term]
id: MP:0030957
name: abnormal myotube morphology
def: "any structural anomaly of any of the multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse" [GO:0014902, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000729 ! abnormal myogenesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T10:51:42Z" xsd:dateTime

[Term]
id: MP:0030958
name: abnormal myotube differentiation
def: "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myotube cell; myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step); then individual myotubes fuse to form bigger myotubes and start to contract" [GO:0014902]
is_a: MP:0005076 ! abnormal cell differentiation
is_a: MP:0030957 ! abnormal myotube morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T10:59:16Z" xsd:dateTime

[Term]
id: MP:0030959
name: abnormal myoblast fusion
def: "any anomaly in the process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers; a myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers" [GO:0007520, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030958 ! abnormal myotube differentiation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T11:05:08Z" xsd:dateTime

[Term]
id: MP:0030960
name: abnormal diapedesis
def: "any anomaly in the passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation" [GO:0050904, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009858 ! abnormal cellular extravasation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T11:28:33Z" xsd:dateTime

[Term]
id: MP:0030961
name: abnormal outer hair cell kinocilium location or orientation
def: "outer hair cell kinocilia are displaced from the normal position and/or do not orient in a typical pattern" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal OHC kinocilium location or orientation" EXACT []
synonym: "mispositioned OHC kinocilia" EXACT []
synonym: "mispositioned outer hair cell kinocilia" EXACT []
is_a: MP:0011062 ! abnormal outer hair cell kinocilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T11:40:40Z" xsd:dateTime

[Term]
id: MP:0030962
name: abnormal inner hair cell kinocilium location or orientation
def: "inner hair cell kinocilia are displaced from the normal position and/or do not orient in a typical pattern" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal IHC kinocilium location or orientation" EXACT []
synonym: "mispositioned IHC kinocilia" EXACT []
synonym: "mispositioned inner hair cell kinocilia" EXACT []
is_a: MP:0011061 ! abnormal inner hair cell kinocilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T12:08:04Z" xsd:dateTime

[Term]
id: MP:0030963
name: abnormal brain ependyma motile cilium location or orientation
def: "brain ependyma motile cilia are displaced from the normal position and/or do not orient in a typical pattern" [https://orcid.org/0000-0002-6490-7723]
synonym: "mispositioned brain ependyma motile cilia" EXACT []
synonym: "mispositioned brain ependymal cilia" EXACT []
is_a: MP:0011056 ! abnormal brain ependyma motile cilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T12:20:55Z" xsd:dateTime

[Term]
id: MP:0030964
name: decreased brain ependyma motile cilium length
def: "reduced length of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert to move cerebrospinal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased brain ependyma motile cilia length" EXACT []
synonym: "decreased brain ventricle motile cilia length" EXACT []
synonym: "decreased brain ventricle motile cilium length" EXACT []
synonym: "reduced brain ependyma motile cilia length" EXACT []
synonym: "reduced brain ependyma motile cilium length" EXACT []
synonym: "short brain ependyma motile cilia" EXACT []
synonym: "short brain ependyma motile cilium" EXACT []
is_a: MP:0011056 ! abnormal brain ependyma motile cilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T12:29:29Z" xsd:dateTime

[Term]
id: MP:0030965
name: increased brain ependyma motile cilium length
def: "increased length of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert to move cerebrospinal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlongated brain ependyma motile cilia" EXACT []
synonym: "enlongated brain ependyma motile cilium" EXACT []
synonym: "increased brain ependyma motile cilia length" EXACT []
synonym: "increased brain ventricle motile cilia length" EXACT []
synonym: "increased brain ventricle motile cilium length" EXACT []
is_a: MP:0011056 ! abnormal brain ependyma motile cilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T12:36:28Z" xsd:dateTime

[Term]
id: MP:0030966
name: decreased brain ependyma motile cilium number
def: "reduced number of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert to move cerebrospinal fluid" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased brain ependyma motile cilia number" EXACT []
synonym: "decreased brain ventricle motile cilia number" EXACT []
synonym: "decreased brain ventricle motile cilium number" EXACT []
synonym: "reduced brain ependyma motile cilia number" EXACT []
synonym: "reduced brain ependyma motile cilium number" EXACT []
synonym: "reduced brain ventricle motile cilia number" EXACT []
synonym: "reduced brain ventricle motile cilium number" EXACT []
is_a: MP:0011056 ! abnormal brain ependyma motile cilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-02T12:45:44Z" xsd:dateTime

[Term]
id: MP:0030967
name: abnormal circulating adiponectin level
def: "any anomaly in the blood concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004891 ! abnormal adiponectin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0030968
name: decreased circulating adiponectin level
def: "less than the normal concentration in the blood of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased plasma adiponectin level" NARROW []
synonym: "decreased serum adiponectin level" NARROW []
synonym: "hypoadiponectinaemia" EXACT []
synonym: "hypoadiponectinemia" EXACT []
synonym: "reduced circulating adiponectin level" EXACT []
synonym: "reduced plasma adiponectin level" NARROW []
synonym: "reduced serum adiponectin level" NARROW []
is_a: MP:0004893 ! decreased adiponectin level
is_a: MP:0030967 ! abnormal circulating adiponectin level

[Term]
id: MP:0030969
name: increased circulating adiponectin level
def: "greater than the normal concentration in the blood of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated circulating adiponectin level" EXACT []
synonym: "hyperadiponectinaemia" EXACT []
synonym: "hyperadiponectinemia" EXACT []
synonym: "increased plasma adiponectin level" NARROW []
synonym: "increased serum adiponectin level" NARROW []
is_a: MP:0004892 ! increased adiponectin level
is_a: MP:0030967 ! abnormal circulating adiponectin level

[Term]
id: MP:0030970
name: ketosis
def: "an abnormal increase of ketone bodies in the body tissues; it is typically pathological in conditions such as diabetes, or may be the consequence of a diet that is very low in carbohydrates" [HP:0001946, https://www.merriam-webster.com/dictionary/ketosis]
synonym: "high levels of ketone bodies" EXACT []
synonym: "hyperketosis" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-12T15:30:40Z" xsd:dateTime

[Term]
id: MP:0030971
name: ketoacidosis
def: "acidosis resulting from accumulation of ketone bodies" [HP:0001993]
is_a: MP:0003031 ! acidosis
is_a: MP:0030970 ! ketosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-12T15:39:15Z" xsd:dateTime

[Term]
id: MP:0030972
name: increased myoblast apoptosis
def: "increase in the number of myoblasts undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000729 ! abnormal myogenesis
is_a: MP:0006042 ! increased apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-12T17:31:10Z" xsd:dateTime

[Term]
id: MP:0030973
name: impaired gluconeogenesis
def: "reduction in the rate of formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol" [GO:0006094, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased gluconeogenesis" EXACT []
synonym: "decreased glucose biosynthesis" EXACT []
synonym: "reduced gluconeogenesis" EXACT []
is_a: MP:0003383 ! abnormal gluconeogenesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-12T17:49:40Z" xsd:dateTime

[Term]
id: MP:0030974
name: enhanced gluconeogenesis
def: "increase in the rate of formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol" [GO:0006094, https://orcid.org/0000-0002-6490-7723]
synonym: "elevated gluconeogenesis" EXACT []
synonym: "increased gluconeogenesis" EXACT []
synonym: "increased glucose biosynthesis" EXACT []
is_a: MP:0003383 ! abnormal gluconeogenesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-07-12T17:56:18Z" xsd:dateTime

[Term]
id: MP:0030975
name: placenta hemorrhage
def: "presence of bleeding in the placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "placenta haemorrhage" EXACT []
synonym: "placental bleeding" EXACT []
synonym: "placental haemorrhage" EXACT []
synonym: "placental hemorrhage" EXACT []
is_a: MP:0001914 ! hemorrhage
is_a: MP:0010038 ! abnormal placenta physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T08:49:39Z" xsd:dateTime

[Term]
id: MP:0030976
name: impaired sperm penetration of zona pellucida
def: "reduced ability or inability of sperm to infiltrate the zona pellucida in order to reach the oocyte; the process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm" [GO:0007341, https://orcid.org/0000-0002-6490-7723]
synonym: "impaired penetration of zona pellucida" EXACT []
is_a: MP:0000242 ! impaired fertilization
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T09:36:36Z" xsd:dateTime

[Term]
id: MP:0030977
name: impaired sperm-egg recognition
def: "reduced ability or inability to establish the initial contact between the sperm plasma membrane and the outer layer of the egg during fertilization" [GO:0035036, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000242 ! impaired fertilization
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T09:59:27Z" xsd:dateTime

[Term]
id: MP:0030978
name: impaired binding of sperm to zona pellucida
def: "reduced ability or inability to execute the process in which the sperm binds to the zona pellucida glycoprotein layer of the egg; the process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place" [GO:0007339, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030977 ! impaired sperm-egg recognition
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T10:05:38Z" xsd:dateTime

[Term]
id: MP:0030979
name: decreased spinal cord weight
def: "lower than average weight of the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "low spinal cord weight" EXACT []
synonym: "reduced spinal cord weight" EXACT []
is_a: MP:0000956 ! decreased spinal cord size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T10:19:38Z" xsd:dateTime

[Term]
id: MP:0030980
name: abnormal acroplaxome morphology
def: "any structural anomaly of the F-actin-keratin cytoskeletal plate limited by a desmosome-like marginal ring that anchors the developing acrosome to the nuclear envelope and is thought to play a pivotal role in acrosome biogenesis and spermatid head shaping" [PMID:14551252, PMID:22319670]
is_a: MP:0009230 ! abnormal sperm head morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-16T13:35:03Z" xsd:dateTime

[Term]
id: MP:0030981
name: abnormal dentate gyrus subgranular zone morphology
def: "any structural anomaly of the the narrow layer of cells located between the granule cell layer and hilus of the dentate gyrus, where adult neurogenesis occurs" [https://orcid.org/0000-0002-6490-7723, UBERON:0009952]
synonym: "abnormal SGZ morphology" EXACT []
synonym: "abnormal subgranular zone morphology" EXACT []
synonym: "abnormal subgranular zone of dentate gyrus morphology" EXACT []
is_a: MP:0000812 ! abnormal dentate gyrus morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-30T08:57:28Z" xsd:dateTime

[Term]
id: MP:0030982
name: abnormal copulatory plug deposition
def: "anomaly in the deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation; probably acts to prevent subsequent matings by other males" [GO:0042628]
comment: This term should be used when the cause is either behavioral or unknown.
synonym: "abnormal mating plug deposition" EXACT []
synonym: "abnormal mating plug formation" BROAD []
synonym: "abnormal vaginal plug deposition" EXACT []
synonym: "abnormal vaginal plug formation" BROAD []
is_a: MP:0009697 ! abnormal copulation behavior
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-30T09:43:35Z" xsd:dateTime

[Term]
id: MP:0030983
name: failure of copulatory plug deposition
def: "inability to initiate and/or complete the deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation" [GO:0042628, https://orcid.org/0000-0002-6490-7723]
comment: This term should be used when the cause is either behavioral or unknown.
synonym: "absent copulatory plug deposition" EXACT []
synonym: "absent mating plug formation" BROAD []
synonym: "absent vaginal plug deposition" EXACT []
synonym: "failure of mating plug deposition" EXACT []
synonym: "failure of mating plug formation" BROAD []
synonym: "failure of vaginal plug formation" BROAD []
is_a: MP:0030982 ! abnormal copulatory plug deposition
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-09-30T09:51:50Z" xsd:dateTime

[Term]
id: MP:0030984
name: increased circulating osteocalcin level
def: "greater than the normal blood concentration of this noncollagenous protein hormone found in bone and dentin, which is secreted by osteoblasts" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased circulating BGLAP level" EXACT []
synonym: "increased circulating bone gamma-carboxyglutamic acid-containing protein level" EXACT []
is_a: MP:0011922 ! abnormal circulating osteocalcin level
is_a: MP:0014456 ! increased circulating hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T06:34:07Z" xsd:dateTime

[Term]
id: MP:0030985
name: decreased circulating osteocalcin level
def: "less than the normal blood concentration of this noncollagenous protein hormone found in bone and dentin, which is secreted by osteoblasts" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased circulating BGLAP level" EXACT []
synonym: "decreased circulating bone gamma-carboxyglutamic acid-containing protein level" EXACT []
synonym: "reduced circulating osteocalcin level" EXACT []
is_a: MP:0011922 ! abnormal circulating osteocalcin level
is_a: MP:0014457 ! decreased circulating hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T06:40:09Z" xsd:dateTime

[Term]
id: MP:0030986
name: striatum atrophy
def: "acquired diminution of the size of the striatum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic striate body" EXACT []
synonym: "atrophic striatum" EXACT []
synonym: "striatal atrophy" EXACT []
synonym: "striate body atrophy" EXACT []
is_a: MP:0012468 ! decreased striatum size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T07:25:27Z" xsd:dateTime

[Term]
id: MP:0030987
name: spinal cord inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the spinal cord" [https://orcid.org/0000-0002-6490-7723]
synonym: "myelitis" EXACT []
is_a: MP:0006082 ! CNS inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T07:37:22Z" xsd:dateTime

[Term]
id: MP:0030988
name: dysosmia
def: "any qualitative alteration or distortion of the perception of smell; qualitative alterations differ from quantitative alterations, which include anosmia and hyposmia" [https://en.wikipedia.org/wiki/Dysosmia]
is_a: MP:0001984 ! abnormal olfaction
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T08:14:31Z" xsd:dateTime

[Term]
id: MP:0030989
name: decreased spongiotrophoblast cell number
def: "reduction in the number of trophoblast cells that arise in the junctional zone of the placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced spongiotrophoblast cell number" EXACT []
is_a: MP:0008959 ! abnormal spongiotrophoblast cell morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T08:45:01Z" xsd:dateTime

[Term]
id: MP:0030990
name: nerve inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in one or more nerves" [https://orcid.org/0000-0002-6490-7723]
synonym: "neuritis" EXACT []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003633 ! abnormal nervous system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T08:55:56Z" xsd:dateTime

[Term]
id: MP:0030991
name: optic nerve inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the optic nerve" [https://orcid.org/0000-0002-6490-7723]
synonym: "optic neuritis" EXACT []
is_a: MP:0030990 ! nerve inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T09:13:44Z" xsd:dateTime

[Term]
id: MP:0030992
name: atrioventricular cushion hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the atrioventricular cushion, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "endocardial cushion hypoplasia" BROAD []
synonym: "hypoplastic atrioventricular cushion" EXACT []
synonym: "hypoplastic endocardial cushion" BROAD []
is_a: MP:0000301 ! decreased atrioventricular cushion size
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T09:25:42Z" xsd:dateTime

[Term]
id: MP:0030993
name: abnormal adipose tissue glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fat tissue glycogen level" EXACT []
is_a: MP:0000003 ! abnormal adipose tissue morphology
is_a: MP:0005437 ! abnormal glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T10:19:40Z" xsd:dateTime

[Term]
id: MP:0030994
name: decreased adipose tissue glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased fat tissue glycogen level" EXACT []
synonym: "reduced adipose tissue glycogen level" EXACT []
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0030993 ! abnormal adipose tissue glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T10:28:42Z" xsd:dateTime

[Term]
id: MP:0030995
name: increased adipose tissue glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased fat tissue glycogen level" EXACT []
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0030993 ! abnormal adipose tissue glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-10-31T10:34:07Z" xsd:dateTime

[Term]
id: MP:0030996
name: decreased pacinian corpuscle number
def: "fewer than the expected number of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers and transmit signals generated by vibrations when grasping an object" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lamellar corpuscle number" EXACT []
synonym: "decreased lamellated corpuscle number" EXACT []
synonym: "reduced lamellar corpuscle number" EXACT []
synonym: "reduced lamellated corpuscle number" EXACT []
synonym: "reduced pacinian corpuscle number" EXACT []
is_a: MP:0000988 ! abnormal pacinian corpuscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T08:01:30Z" xsd:dateTime

[Term]
id: MP:0030997
name: absent pacinian corpuscles
def: "absence of all of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers and transmit signals generated by vibrations when grasping an object" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent lamellar corpuscles" EXACT []
synonym: "absent lamellated corpuscles" EXACT []
is_a: MP:0030996 ! decreased pacinian corpuscle number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T08:14:47Z" xsd:dateTime

[Term]
id: MP:0030998
name: small pacinian corpuscles
def: "decreased size of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers and transmit signals generated by vibrations when grasping an object" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lamellar corpuscle size" EXACT []
synonym: "decreased lamellated corpuscle size" EXACT []
synonym: "decreased pacinian corpuscle size" EXACT []
synonym: "reduced lamellar corpuscle size" EXACT []
synonym: "reduced lamellated corpuscle size" EXACT []
synonym: "reduced pacinian corpuscle size" EXACT []
synonym: "small lamellar corpuscles" EXACT []
synonym: "small lamellated corpuscles" EXACT []
is_a: MP:0000988 ! abnormal pacinian corpuscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T08:21:40Z" xsd:dateTime

[Term]
id: MP:0030999
name: abnormal glycogen synthesis
def: "any anomaly in the reactions and pathways involved in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues" [GO:0005978, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal glycogen anabolism" EXACT []
synonym: "abnormal glycogen biosynthesis" EXACT []
synonym: "abnormal glycogen biosynthetic process" EXACT []
synonym: "abnormal glycogen formation" EXACT []
is_a: MP:0005438 ! abnormal glycogen homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T10:10:55Z" xsd:dateTime

[Term]
id: MP:0031000
name: decreased glycogen synthesis
def: "any anomaly in the reactions and pathways involved in glycogen biosynthesis that results in reduced glycogen formation" [GO:0005978, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased glycogen biosynthesis" EXACT []
synonym: "decreased glycogen formation" EXACT []
synonym: "impaired glycogen anabolism" EXACT []
synonym: "impaired glycogen biosynthesis" EXACT []
synonym: "impaired glycogen biosynthetic process" EXACT []
synonym: "impaired glycogen synthesis" EXACT []
synonym: "reduced glycogen biosynthesis" EXACT []
synonym: "reduced glycogen formation" EXACT []
synonym: "reduced glycogen synthesis" EXACT []
is_a: MP:0030999 ! abnormal glycogen synthesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T10:17:34Z" xsd:dateTime

[Term]
id: MP:0031001
name: increased glycogen synthesis
def: "any anomaly in the reactions and pathways involved in glycogen biosynthesis that results in increased glycogen formation" [GO:0005978, https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced glycogen biosynthesis" EXACT []
synonym: "enhanced glycogen formation" EXACT []
synonym: "enhanced glycogen synthesis" EXACT []
synonym: "increased glycogen anabolism" EXACT []
synonym: "increased glycogen biosynthesis" EXACT []
synonym: "increased glycogen biosynthetic process" EXACT []
synonym: "increased glycogen formation" EXACT []
is_a: MP:0030999 ! abnormal glycogen synthesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T10:26:07Z" xsd:dateTime

[Term]
id: MP:0031002
name: abnormal kidney glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal renal glycogen level" EXACT []
is_a: MP:0002135 ! abnormal kidney morphology
is_a: MP:0005437 ! abnormal glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T10:47:17Z" xsd:dateTime

[Term]
id: MP:0031003
name: increased kidney glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased renal glycogen level" EXACT []
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0031002 ! abnormal kidney glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T11:08:40Z" xsd:dateTime

[Term]
id: MP:0031004
name: decreased kidney glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in kidney" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased renal glycogen level" EXACT []
synonym: "reduced kidney glycogen level" EXACT []
synonym: "reduced renal glycogen level" EXACT []
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0031002 ! abnormal kidney glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T11:13:47Z" xsd:dateTime

[Term]
id: MP:0031005
name: abnormal lung glycogen level
def: "any anomaly in the concentration of a readily converted carbohydrate reserve in lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pulmonary glycogen level" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0005437 ! abnormal glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T11:31:13Z" xsd:dateTime

[Term]
id: MP:0031006
name: increased lung glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased pulmonary glycogen level" EXACT []
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0031005 ! abnormal lung glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T11:35:34Z" xsd:dateTime

[Term]
id: MP:0031007
name: decreased lung glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased pulmonary glycogen level" EXACT []
synonym: "reduced lung glycogen level" EXACT []
synonym: "reduced pulmonary glycogen level" EXACT []
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0031005 ! abnormal lung glycogen level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T11:39:31Z" xsd:dateTime

[Term]
id: MP:0031008
name: decreased bone marrow adipose tissue amount
def: "decreased quantity of the bone marrow fat-storing cells/tissue" [PMID:25934999, RGD:sjwang]
synonym: "decreased bone marrow fat amount" EXACT []
synonym: "reduced bone marrow adipose tissue amount" EXACT []
synonym: "reduced bone marrow fat" EXACT []
is_a: MP:0030008 ! abnormal bone marrow adipose tissue amount
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2019-12-16T12:36:50Z" xsd:dateTime

[Term]
id: MP:0031009
name: abnormal sperm-egg fusion
def: "any anomaly in the binding and fusion of a sperm with the plasma membrane of the oocyte during the process of fertilization" [GO:0007342]
synonym: "abnormal fusion of sperm to egg plasma membrane" EXACT []
synonym: "abnormal sperm-oocyte fusion" EXACT []
is_a: MP:0005410 ! abnormal fertilization
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T09:55:18Z" xsd:dateTime

[Term]
id: MP:0031010
name: failure of sperm-egg fusion
def: "failure to initiate and/or complete the binding and fusion of a sperm with the plasma membrane of the oocyte during the process of fertilization" [GO:0007342, https://orcid.org/0000-0002-6490-7723]
synonym: "failure of sperm to egg plasma membrane fusion" EXACT []
synonym: "failure of sperm-oocyte fusion" EXACT []
is_a: MP:0000242 ! impaired fertilization
is_a: MP:0031009 ! abnormal sperm-egg fusion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T10:12:01Z" xsd:dateTime

[Term]
id: MP:0031011
name: abnormal sperm migration in female genital tract
def: "any anomaly in the ability of ejaculated sperm to migrate through the female genital tract to reach the oocyte in the oviduct; during their transit in the female tract, sperm encounter different environments with various mechanical and biochemical properties; to complete the journey, each sperm has to swim in a highly viscous medium in the cervix, avoid immunological detection in the uterus, cross the uterotubal junction, and ascend into the oviduct isthmus to ultimately reach the site of fertilization, the ampullary region of the oviduct" [PMID:29353867]
synonym: "abnormal sperm migration through the female reproductive tract" EXACT []
is_a: MP:0003091 ! abnormal cell migration
is_a: MP:0004543 ! abnormal sperm physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T10:51:59Z" xsd:dateTime

[Term]
id: MP:0031012
name: impaired sperm migration in female genital tract
def: "impaired ability of ejaculated sperm to migrate through the female genital tract and reach the oocyte at the site of fertilization, the ampullary region of the oviduct" [PMID:29353867]
synonym: "impaired sperm migration through the female reproductive tract" EXACT []
is_a: MP:0031011 ! abnormal sperm migration in female genital tract
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T11:02:18Z" xsd:dateTime

[Term]
id: MP:0031013
name: abnormal egg activation
def: "any anomaly in the series of biochemical and morphological events that converts a metaphase-II-arrested oocyte into a fertilized egg ready to begin embryogenesis; in most mammals, oocyte activation is a spatial-temporal regulated process induced by sperm entry that involves early events such a transient rise in intracellular calcium concentration, cortical granule exocytosis and meiotic cell-cycle resumption, and later events such as pronuclear formation, translation of maternal mRNAs and meiosis-to-mitosis transition" [GO:0007343, https://doi.org/10.1016/J.RBMO.2014.01.008, ISBN:978-0-12-812571-7, PMID:10091064]
synonym: "abnormal oocyte activation" EXACT []
synonym: "abnormal ovum activation" EXACT []
is_a: MP:0005410 ! abnormal fertilization
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T11:22:13Z" xsd:dateTime

[Term]
id: MP:0031014
name: polyspermy
def: "increased incidence of fertilized oocytes fused with two or more sperm due to reduced ability or inability to prevent fertilization by multiple sperm during the egg activation process; normally only a single sperm fuses with the egg plasma membrane and injects its nucleus and other organelles into the egg cytoplasm; if more than one sperm fuses, multipolar or extra mitotic spindles are formed, resulting in faulty segregation of chromosomes during cell division; nondiploid cells are produced, and development usually stops" [ISBN-10:0-8153-4072-9, PMID:16478602]
synonym: "failure of polyspermy block" RELATED []
synonym: "failure of polyspermy prevention" RELATED []
synonym: "polyspermic fertilization" EXACT []
is_a: MP:0031013 ! abnormal egg activation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T11:47:39Z" xsd:dateTime

[Term]
id: MP:0031015
name: abnormal granulosa cell apoptosis
def: "change in the timing or the number of granulosa cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013506 ! abnormal ovary apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T12:07:06Z" xsd:dateTime

[Term]
id: MP:0031016
name: decreased granulosa cell apoptosis
def: "decrease in the number of granulosa cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced granulosa cell apoptosis" EXACT []
is_a: MP:0031015 ! abnormal granulosa cell apoptosis
is_a: MP:0031476 ! decreased ovary apoptosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T12:19:47Z" xsd:dateTime

[Term]
id: MP:0031017
name: abnormal granulosa cell proliferation
def: "anomaly in the ability of a granulosa cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0003507 ! abnormal ovary physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T12:43:14Z" xsd:dateTime

[Term]
id: MP:0031018
name: decreased granulosa cell proliferation
def: "reduction in the expansion rate of a granulosa cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced granulosa cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0031017 ! abnormal granulosa cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T12:50:35Z" xsd:dateTime

[Term]
id: MP:0031019
name: increased granulosa cell proliferation
def: "increase in the expansion rate of a granulosa cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated granulosa cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0031017 ! abnormal granulosa cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T12:59:24Z" xsd:dateTime

[Term]
id: MP:0031020
name: premature ovarian failure
def: "cessation of ovarian function occurring at an earlier than expected age" [https://orcid.org/0000-0002-6490-7723]
synonym: "accelerated loss of ovarian function" EXACT []
synonym: "early cessation of ovarian function" EXACT []
synonym: "precocious ovarian failure" EXACT []
is_a: MP:0003507 ! abnormal ovary physiology
is_a: MP:0008995 ! early reproductive senescence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-01-07T13:21:18Z" xsd:dateTime

[Term]
id: MP:0031021
name: abnormal gallbladder smooth muscle morphology
def: "any structural anomaly of the layer of loose smooth muscle bundles (tunica muscularis) located beneath the mucosa of the gallbladder wall and composed of fibers that are not arranged in distinct layers but lie in circular, longitudinal, and oblique directions; when these fibers contract, the gallbladder’s contents are released through the cystic duct into the bile duct and eventually emptied into the duodenum to aid in the digestion of fats" [https://en.wikipedia.org/wiki/Gallbladder, https://www.histology.leeds.ac.uk/digestive/gallbladder.php]
is_a: MP:0000767 ! abnormal smooth muscle morphology
is_a: MP:0005084 ! abnormal gallbladder morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-02-06T07:58:48Z" xsd:dateTime

[Term]
id: MP:0031022
name: hepatic megalocytosis
def: "a condition in which hepatocytes exhibit gross enlargement of cytoplasmic and nuclear volume without the formation of mitotic spindles and mitosis, potentially indicating irreversible injury" [https://doi.org/10.1016/B978-0-08-046884-6.01026-5, PMID:11509115, RGD:sjwang]
is_a: MP:0000607 ! abnormal hepatocyte morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-02-06T08:57:13Z" xsd:dateTime

[Term]
id: MP:0031023
name: decreased susceptibility to Riboviria infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Riboviria iinfection or from components of or toxins produced by a virus from this Realm" [NCBITaxon:2559587, url:https\://www.sciencedirect.com/science/article/pii/B9780128096338212314]
synonym: "increased resistance to Riboviria infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Riboviria infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020914 ! decreased susceptibility to Riboviria infection

[Term]
id: MP:0031024
name: increased susceptibility to Riboviria infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Riboviria iinfection or from components of or toxins produced by a virus from this Realm" [NCBITaxon:2559587, url:https\://www.sciencedirect.com/science/article/pii/B9780128096338212314]
synonym: "decreased resistance to Riboviria infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Riboviria infection induced morbidity/mortality" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020913 ! increased susceptibility to Riboviria infection

[Term]
id: MP:0031025
name: decreased susceptibility to Herpesvirales infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Herpesvirales infection or from components of or toxins produced by a virus from this Order" [NCBITaxon:548681, PMID:19066710]
synonym: "increased resistance to Herpesvirales infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Herpesvirales infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020917 ! decreased susceptibility to Herpesvirales infection

[Term]
id: MP:0031026
name: increased susceptibility to Herpesvirales infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Herpesvirales infection or from components of or toxins produced by a virus from this Order" [NCBITaxon:548681, PMID:19066710]
synonym: "decreased resistance to Herpesvirales infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Herpesvirales infection induced morbidity/mortalit" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020916 ! increased susceptibility to Herpesvirales infection

[Term]
id: MP:0031027
name: decreased susceptibility to Ortervirales infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by an Ortervirales infection or from components of or toxins produced by a virus from this Order" [NCBITaxon:2169561, PMID:29618642]
synonym: "increased resistance to Ortervirales infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Ortervirales infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020920 ! decreased susceptibility to Ortervirales infection

[Term]
id: MP:0031028
name: increased susceptibility to Ortervirales infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by an Ortervirales infection or from components of or toxins produced by a virus from this Order" [NCBITaxon:2169561, PMID:29618642]
synonym: "decreased resistance to Ortervirales infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Ortervirales infection induced morbidity/mortality" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020919 ! increased susceptibility to Ortervirales infection

[Term]
id: MP:0031029
name: decreased susceptibility to Parvoviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Parvoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10780, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/ssdna-viruses/w/parvoviridae]
synonym: "increased resistance to Parvoviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Parvoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020923 ! decreased susceptibility to Parvoviridae infection

[Term]
id: MP:0031030
name: increased susceptibility to Parvoviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Parvoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10780, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/ssdna-viruses/w/parvoviridae]
synonym: "decreased resistance to Parvoviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Parvoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020922 ! increased susceptibility to Parvoviridae infection

[Term]
id: MP:0031031
name: decreased susceptibility to Hepadnaviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Hepadnaviridae infection or from components of or toxins produced by a virus from this Family" [url:https\://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/hepadnaviridae]
synonym: "increased resistance to Hepadnaviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Hepadnaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020926 ! decreased susceptibility to Hepadnaviridae infection
is_a: MP:0031027 ! decreased susceptibility to Ortervirales infection induced morbidity/mortality

[Term]
id: MP:0031032
name: increased susceptibility to Hepadnaviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Hepadnaviridae infection or from components of or toxins produced by a virus from this Family" [url:https\://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/hepadnaviridae]
synonym: "decreased resistance to Hepadnaviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Hepadnaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020925 ! increased susceptibility to Hepadnaviridae infection
is_a: MP:0031028 ! increased susceptibility to Ortervirales infection induced morbidity/mortality

[Term]
id: MP:0031033
name: decreased susceptibility to Poxviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Poxviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10240, PMID:29145493]
synonym: "increased resistance to Poxviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Poxviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020929 ! decreased susceptibility to Poxviridae infection

[Term]
id: MP:0031034
name: increased susceptibility to Poxviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Poxviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10240, PMID:29145493]
synonym: "decreased resistance to Poxviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Poxviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020928 ! increased susceptibility to Poxviridae infection

[Term]
id: MP:0031035
name: decreased susceptibility to Adenoviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by an Adenoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10508, url:https\://www.sciencedirect.com/topics/neuroscience/adenoviridae]
synonym: "increased resistance to Adenoviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Adenoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009790 ! decreased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020932 ! decreased susceptibility to Adenoviridae infection

[Term]
id: MP:0031036
name: increased susceptibility to Adenoviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by an Adenoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:10508, url:https\://www.sciencedirect.com/topics/neuroscience/adenoviridae]
synonym: "decreased resistance to Adenoviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Adenoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0009791 ! increased susceptibility to viral infection induced morbidity/mortality
is_a: MP:0020931 ! increased susceptibility to Adenoviridae infection

[Term]
id: MP:0031037
name: decreased susceptibility to Retroviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Retroviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11632, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/retrovirus]
synonym: "increased resistance to Retroviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Retroviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020935 ! decreased susceptibility to Retroviridae infection
is_a: MP:0031027 ! decreased susceptibility to Ortervirales infection induced morbidity/mortality

[Term]
id: MP:0031038
name: increased susceptibility to Retroviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Retroviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11632, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/retrovirus]
synonym: "decreased resistance to Retroviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Retroviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020934 ! increased susceptibility to Retroviridae infection
is_a: MP:0031028 ! increased susceptibility to Ortervirales infection induced morbidity/mortality

[Term]
id: MP:0031039
name: decreased susceptibility to Picornaviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Picornaviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:12058, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae]
synonym: "increased resistance to Picornaviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Picornaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020938 ! decreased susceptibility to Picornaviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031040
name: increased susceptibility to Picornaviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Picornaviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:12058, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae]
synonym: "decreased resistance to Picornaviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitvity to Picornaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020937 ! increased susceptibility to Picornaviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031041
name: decreased susceptibility to Togaviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Togaviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11018, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/togaviridae]
synonym: "increased resistance to Togaviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Togaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020941 ! decreased susceptibility to Togaviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031042
name: increased susceptibility to Togaviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Togaviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11018, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/togaviridae]
synonym: "decreased resistance to Togaviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Togaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020940 ! increased susceptibility to Togaviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031043
name: decreased susceptibility to Flaviviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Flaviviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11050, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae]
synonym: "increased resistance to Flaviviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Flaviviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020944 ! decreased susceptibility to Flaviviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031044
name: increased susceptibility to Flaviviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Flaviviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11050, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae]
synonym: "decreased resistance to Flaviviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Flaviviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020943 ! increased susceptibility to Flaviviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031045
name: decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by an Orthomyxoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11308, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/orthomyxoviridae]
synonym: "increased resistance to Orthomyxoviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Orthomyxoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020947 ! decreased susceptibility to Orthomyxoviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031046
name: increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by an Orthomyxoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11308, url:https\://www.sciencedirect.com/topics/immunology-and-microbiology/orthomyxoviridae]
synonym: "decreased resistance to Orthomyxoviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Orthomyxoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020946 ! increased susceptibility to Orthomyxoviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031047
name: decreased susceptibility to Coronaviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Coronaviridae infection or from components of or toxins produced by a virus from this Family" [PMID:30568804, PMID:6654644]
synonym: "increased resistance to Coronaviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Coronaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020950 ! decreased susceptibility to Coronaviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031048
name: increased susceptibility to Coronaviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Coronaviridae infection or from components of or toxins produced by a virus from this Family" [PMID:30568804, PMID:6654644]
synonym: "decreased resistance to Coronaviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Coronaviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020949 ! increased susceptibility to Coronaviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031049
name: decreased susceptibility to Paramyxoviridae infection induced morbidity/mortality
def: "decreased likelihood that an organism will display the expected moribund state caused by a Paramyxoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11158, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/mononegavirales/w/paramyxoviridae]
synonym: "increased resistance to Paramyxoviridae infection induced morbidity/mortality" EXACT []
synonym: "reduced sensitivity to Paramyxoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020953 ! decreased susceptibility to Paramyxoviridae infection
is_a: MP:0031023 ! decreased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031050
name: increased susceptibility to Paramyxoviridae infection induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by a Paramyxoviridae infection or from components of or toxins produced by a virus from this Family" [NCBITaxon:11158, url:https\://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/mononegavirales/w/paramyxoviridae]
synonym: "decreased resistance to Paramyxoviridae infection induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to Paramyxoviridae infection induced morbidity/mortality" EXACT []
is_a: MP:0020952 ! increased susceptibility to Paramyxoviridae infection
is_a: MP:0031024 ! increased susceptibility to Riboviria infection induced morbidity/mortality

[Term]
id: MP:0031051
name: lymph node hemorrhage
def: "bleeding into one or more lymph nodes" [https://orcid.org/0000-0002-6490-7723]
synonym: "haemorrhagic lymph node" EXACT []
synonym: "hemorrhagic lymph node" EXACT []
synonym: "lymph node haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0003762 ! abnormal immune organ physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T13:31:07Z" xsd:dateTime

[Term]
id: MP:0031052
name: lymph node necrosis
def: "morphological changes resulting from pathological death of some or all lymph node tissue; usually due to irreversible damage" [https://orcid.org/0000-0002-6490-7723]
synonym: "necrotic lymph node" EXACT []
synonym: "necrotic lymph nodes" EXACT []
is_a: MP:0002339 ! abnormal lymph node morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T13:54:18Z" xsd:dateTime

[Term]
id: MP:0031053
name: pleuritis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the invaginated serous membrane that surrounds the lungs (visceral portion) and lines the walls of the pleural cavity (parietal portion)" [https://orcid.org/0000-0002-6490-7723]
synonym: "pleura inflammation" EXACT []
synonym: "pleurisy" EXACT []
is_a: MP:0002405 ! respiratory system inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T14:05:07Z" xsd:dateTime

[Term]
id: MP:0031054
name: bronchiolitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the noncartilaginous conducting airways of the lungs found terminal to the bronchi" [https://orcid.org/0000-0002-6490-7723]
synonym: "bronchiolar inflammation" EXACT []
is_a: MP:0001861 ! lung inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T14:21:39Z" xsd:dateTime

[Term]
id: MP:0031055
name: bronchitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the bronchial tubes" [https://orcid.org/0000-0002-6490-7723]
synonym: "bronchial inflammation" EXACT []
synonym: "bronchus inflammation" EXACT []
is_a: MP:0001861 ! lung inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T14:31:54Z" xsd:dateTime

[Term]
id: MP:0031056
name: bitter preference
def: "subjects demonstrate predilection for bitter tasting substances over other offered substances" [https://orcid.org/0000-0002-6490-7723, RGD:gthayman]
is_a: MP:0001432 ! abnormal food preference
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T15:51:35Z" xsd:dateTime

[Term]
id: MP:0031057
name: low bitter preference
def: "subjects demonstrate a low predilection for bitter tasting substances over other offered substances" [https://orcid.org/0000-0002-6490-7723, RGD:gthayman]
is_a: MP:0001432 ! abnormal food preference
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-25T15:56:43Z" xsd:dateTime

[Term]
id: MP:0031058
name: hepatosplenomegaly
def: "simultaneous enlargement of the liver and spleen" [HP:0001433]
synonym: "enlarged liver and spleen" EXACT []
synonym: "enlarged liver and spleen size" EXACT []
synonym: "increased liver and spleen size" EXACT []
is_a: MP:0000599 ! enlarged liver
is_a: MP:0000691 ! enlarged spleen
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:01:17Z" xsd:dateTime

[Term]
id: MP:0031059
name: increased circulating C-reactive protein level
def: "abnormal elevation of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated circulating CRP level" EXACT []
synonym: "increased circulating CRP level" EXACT []
is_a: MP:0010212 ! abnormal circulating C-reactive protein level
is_a: MP:0014499 ! increased acute phase protein level
is_a: MP:0014501 ! increased circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:23:55Z" xsd:dateTime

[Term]
id: MP:0031060
name: decreased circulating C-reactive protein level
def: "abnormal reduction of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased circulating CRP level" EXACT []
synonym: "reduced circulating C-reactive protein level" EXACT []
synonym: "reduced circulating CRP level" EXACT []
is_a: MP:0010212 ! abnormal circulating C-reactive protein level
is_a: MP:0014500 ! decreased acute phase protein level
is_a: MP:0014502 ! decreased circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:30:11Z" xsd:dateTime

[Term]
id: MP:0031061
name: abnormal erythrocyte sedimentation rate
def: "a deviation in the rate at which red blood cells (RBCs) descend under the influence of gravity in a vertical column of anticoagulated whole blood over a period of one hour; the rate at which RBCs settle out from the plasma is measured as the number of millimeters of clear plasma present at the top of the column after one hour (mm/hr); a non-specific measure of inflammation" [HP:0025021, http://www.medicine.mcgill.ca/physio/vlab/bloodlab/esr.htmnerythrocyte]
synonym: "abnormal blood sedimentation rate" EXACT []
synonym: "abnormal ESR" EXACT []
synonym: "abnormal sed rate" RELATED []
synonym: "abnormal Westergren sedimentation rate" EXACT []
is_a: MP:0009642 ! abnormal blood homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:41:08Z" xsd:dateTime

[Term]
id: MP:0031062
name: decreased erythrocyte sedimentation rate
def: "a reduction in the rate at which red blood cells (RBCs) descend under the influence of gravity in a vertical column of anticoagulated whole blood over a period of one hour; a decreased rate may be seen in polycythemia or in certain blood diseases in which RBCs have an irregular or smaller shape that causes slower settling" [HP:0025022, http://www.medicine.mcgill.ca/physio/vlab/bloodlab/esr.htmnerythrocyte]
synonym: "decreased blood sedimentation rate" EXACT []
synonym: "decreased ESR" EXACT []
synonym: "low ESR" EXACT []
synonym: "reduced erythrocyte sedimentation rate" EXACT []
synonym: "reduced ESR" EXACT []
is_a: MP:0031061 ! abnormal erythrocyte sedimentation rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:50:14Z" xsd:dateTime

[Term]
id: MP:0031063
name: increased erythrocyte sedimentation rate
def: "an increase in the rate at which red blood cells descend under the influence of gravity in a vertical column of anticoagulated whole blood over a period of one hour; an elevated rate may indicate inflammation or may be caused by any condition that elevates fibrinogen" [HP:0003565, http://www.medicine.mcgill.ca/physio/vlab/bloodlab/esr.htmnerythrocyte]
synonym: "elevated blood sedimentation rate" EXACT []
synonym: "elevated ESR" EXACT []
synonym: "high ESR" EXACT []
synonym: "increased blood sedimentation rate" EXACT []
synonym: "increased ESR" EXACT []
is_a: MP:0031061 ! abnormal erythrocyte sedimentation rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T12:54:26Z" xsd:dateTime

[Term]
id: MP:0031064
name: abnormal circulating procalcitonin level
def: "any anomaly in the blood concentration of procalcitonin, a peptide precursor of the hormone calcitonin produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine; the level of procalcitonin is virtually undetectable in the bloodstream of healthy individuals but can rise significantly in systemic bacterial infections and sepsis" [https://en.wikipedia.org/wiki/Procalcitonin, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal circulating PCT level" EXACT []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T13:04:11Z" xsd:dateTime

[Term]
id: MP:0031065
name: increased circulating procalcitonin level
def: "greater concentration in the blood of procalcitonin, a peptide precursor of the hormone calcitonin produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine; the level of procalcitonin is virtually undetectable in the bloodstream of healthy individuals but can rise significantly in systemic bacterial infections and sepsis; it does not rise significantly with viral or non-infectious inflammations" [https://en.wikipedia.org/wiki/Procalcitonin, https://orcid.org/0000-0002-6490-7723]
synonym: "increased circulating PCT level" EXACT []
is_a: MP:0031064 ! abnormal circulating procalcitonin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-05-28T13:09:19Z" xsd:dateTime

[Term]
id: MP:0031066
name: cytokine storm
def: "dysregulated and excessive cytokine and chemokine release in response to infection and other stimuli; can cause acute respiratory distress syndrome (ARDS) or multiple-organ dysfunction, leading to physiological deterioration and death" [PMID:32283152]
synonym: "hypercytokinaemia" RELATED []
synonym: "hypercytokinemia" RELATED []
is_a: MP:0001846 ! increased inflammatory response
is_a: MP:0003009 ! abnormal cytokine secretion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T05:29:49Z" xsd:dateTime

[Term]
id: MP:0031067
name: abnormal blood oxygen saturation level
def: "any anomaly in the amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity" [CMO:0001324, https://orcid.org/0000-0002-6490-7723]
comment: When arterial oxy-hemoglobin saturation is measured by an arterial blood gas it is called SaO2; when arterial oxy-hemoglobin saturation is measured non-invasively by a finger pulse oximeter or handheld pulse oximeter, it is called SpO2. {xref="https://www.amperordirect.com/pc/help-pulse-oximeter/z-what-is-oxygen-saturation.html"}
is_a: MP:0002329 ! abnormal blood gas level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T05:54:12Z" xsd:dateTime

[Term]
id: MP:0031068
name: decreased blood oxygen saturation level
def: "a reduction in the amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity" [CMO:0001324, https://orcid.org/0000-0002-6490-7723]
synonym: "low blood oxygen saturation level" EXACT []
synonym: "reduced blood oxygen saturation level" EXACT []
is_a: MP:0031067 ! abnormal blood oxygen saturation level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T06:07:27Z" xsd:dateTime

[Term]
id: MP:0031069
name: increased blood oxygen saturation level
def: "an increase in the amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity" [CMO:0001324, https://orcid.org/0000-0002-6490-7723]
synonym: "high blood oxygen saturation level" EXACT []
is_a: MP:0031067 ! abnormal blood oxygen saturation level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T06:20:58Z" xsd:dateTime

[Term]
id: MP:0031070
name: hemophagocytosis
def: "a pathologic process of engulfment of erythrocytes, leukocytes, platelets, and their precursors by histiocytes, either in the bone marrow or in other parts of the reticuloendothelial system; it is a nonspecific phenotypic feature observed in several conditions including hemolytic anemia, malignant disease, infections, and hemophagocytic syndrome (also known as hemophagocytic lymphohistiocytosis, a rare hyperinflammatory syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune process)" [HP:0012156, http://www.mjdrdypv.org/text.asp?2019/12/1/22/250440]
synonym: "haemophagocytosis" EXACT []
is_a: MP:0002451 ! abnormal macrophage physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T06:35:09Z" xsd:dateTime

[Term]
id: MP:0031071
name: lymph node atrophy
def: "acquired diminution of the size of lymph node tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [https://orcid.org/0000-0002-6490-7723]
synonym: "atrophic lymph node" EXACT []
is_a: MP:0002217 ! small lymph nodes
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T06:55:14Z" xsd:dateTime

[Term]
id: MP:0031072
name: abnormal circulating type I collagen C-terminal telopeptide level
def: "any deviation from the normal amount of type I collagen C-terminal telopeptide (CTX) in the blood circulation; beta-CTX is released into the bloodstream during bone resorption and serves as a specific marker for the degradation of mature type I collagen" [CMO:0002818, https://orcid.org/0000-0002-6490-7723, https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/83175]
synonym: "abnormal blood CTX level" RELATED []
synonym: "abnormal level of blood carboxy-terminal collagen crosslinks" RELATED []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T07:06:40Z" xsd:dateTime

[Term]
id: MP:0031073
name: decreased circulating type I collagen C-terminal telopeptide level
def: "less than the normal amount of type I collagen C-terminal telopeptide (CTX) in the blood circulation; beta-CTX is released into the bloodstream during bone resorption and serves as a specific marker for the degradation of mature type I collagen" [CMO:0002818, https://orcid.org/0000-0002-6490-7723, https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/83175]
synonym: "decreased blood CTX level" RELATED []
synonym: "decreased level of blood carboxy-terminal collagen crosslinks" RELATED []
synonym: "reduced circulating type I collagen C-terminal telopeptide level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031072 ! abnormal circulating type I collagen C-terminal telopeptide level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T07:15:21Z" xsd:dateTime

[Term]
id: MP:0031074
name: increased circulating type I collagen C-terminal telopeptide level
def: "greater than the normal amount of type I collagen C-terminal telopeptide (CTX) in the blood circulation; beta-CTX is released into the bloodstream during bone resorption and serves as a specific marker for the degradation of mature type I collagen; elevated serum levels of beta-CTX indicate increased bone resorption" [CMO:0002818, https://orcid.org/0000-0002-6490-7723, https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/83175]
synonym: "elevated circulating type I collagen C-terminal telopeptide level" EXACT []
synonym: "increased blood CTX level" RELATED []
synonym: "increased level of blood carboxy-terminal collagen crosslinks" RELATED []
synonym: "increased serum type I collagen C-terminal telopeptide level" NARROW []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031072 ! abnormal circulating type I collagen C-terminal telopeptide level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T07:24:29Z" xsd:dateTime

[Term]
id: MP:0031075
name: abnormal circulating troponin level
def: "eviation from the normal concentration in the blood of troponin, a complex of three contractile regulatory proteins (troponin C, T and I) that control the calcium mediated interactions between actin and myosin in cardiac and skeletal muscles; in humans, cardiac-specific troponins I and T are regarded as the preferred biomarkers for the diagnosis of myocardial infarction due to their unique specificity for myocardial cell injury/necrosis" [https://orcid.org/0000-0002-6490-7723, PMID:15452153]
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T10:30:19Z" xsd:dateTime

[Term]
id: MP:0031076
name: decreased circulating troponin level
def: "reduced concentration in the blood of troponin, a complex of three contractile regulatory proteins (troponin C, T and I) that control the calcium mediated interactions between actin and myosin in cardiac and skeletal muscles; in humans, cardiac-specific troponins I and T are regarded as the preferred biomarkers for the diagnosis of myocardial infarction due to their unique specificity for myocardial cell injury/necrosis" [https://orcid.org/0000-0002-6490-7723, PMID:15452153]
synonym: "reduced circulating troponin level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031075 ! abnormal circulating troponin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T10:39:55Z" xsd:dateTime

[Term]
id: MP:0031077
name: increased circulating troponin level
def: "increased concentration in the blood of troponin, a complex of three contractile regulatory proteins (troponin C, T and I) that control the calcium mediated interactions between actin and myosin in cardiac and skeletal muscles; in humans, elevated serum levels of cardiac-specific troponins (I and T) are highly sensitive and specific indicators of myocardial injury and used in the diagnosis of myocardial infarction" [https://orcid.org/0000-0002-6490-7723, PMID:15452153]
synonym: "elevated circulating troponin level" EXACT []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031075 ! abnormal circulating troponin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T10:45:54Z" xsd:dateTime

[Term]
id: MP:0031078
name: increased circulating troponin T level
def: "greater than the normal concentration in the blood of troponin T (TnT), a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin; elevated serum cardiac troponin T levels are highly sensitive and specific indicators of myocardial injury and used in the diagnosis of myocardial infarction" [HP:0410174, https://orcid.org/0000-0002-6490-7723, PMID:15452153]
synonym: "increased serum cardiac troponin T levels" NARROW []
is_a: MP:0031077 ! increased circulating troponin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T10:50:15Z" xsd:dateTime

[Term]
id: MP:0031079
name: increased circulating troponin I level
def: "greater than the normal concentration in the blood of troponin I (TnI), a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin; elevated serum cardiac troponin I levels are highly sensitive and specific indicators of myocardial injury and used in the diagnosis of myocardial infarction" [HP:0410173, https://orcid.org/0000-0002-6490-7723, PMID:15452153]
synonym: "increased serum cardiac troponin I level" NARROW []
is_a: MP:0031077 ! increased circulating troponin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-02T10:55:46Z" xsd:dateTime

[Term]
id: MP:0031080
name: pulmonary embolism
def: "an embolus (an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung; usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery" [HP:0002204]
synonym: "blood clot in artery of lung" EXACT []
synonym: "pulmonary artery embolism" EXACT []
synonym: "pulmonary embolus" EXACT []
is_a: MP:0002295 ! abnormal pulmonary circulation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T08:33:24Z" xsd:dateTime

[Term]
id: MP:0031081
name: abnormal circulating D-dimer level
def: "any anomaly in the concentration in the blood of this fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis; D-dimer constitutes two adjacent fibrin D domains that are cross-linked and released as an intact fragment" [https://en.wikipedia.org/wiki/D-dimer, https://medical-dictionary.thefreedictionary.com/d-dimer+test]
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T09:02:27Z" xsd:dateTime

[Term]
id: MP:0031082
name: decreased circulating D-dimer level
def: "reduced concentration in the blood of this fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis" [https://en.wikipedia.org/wiki/D-dimer, https://medical-dictionary.thefreedictionary.com/d-dimer+test]
synonym: "reduced circulating D-dimer level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031081 ! abnormal circulating D-dimer level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T09:10:32Z" xsd:dateTime

[Term]
id: MP:0031083
name: increased circulating D-dimer level
def: "increased concentration in the blood of this fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis; elevations can occur as a result of thrombotic disease (such as deep-vein thrombosis, pulmonary embolism or disseminated intravascular coagulation), in vasoocclusive crisis of sickle cell anemia, in malignancies, and in surgery" [https://en.wikipedia.org/wiki/D-dimer, https://medical-dictionary.thefreedictionary.com/d-dimer+test]
synonym: "elevated D-dimer level" EXACT []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031081 ! abnormal circulating D-dimer level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T09:14:49Z" xsd:dateTime

[Term]
id: MP:0031084
name: decreased erythrocyte osmotic fragility
def: "decreased propensity of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions; seen in chronic liver disease, iron deficiency anemia, thalassemia, hyponatremia, polycythemia vera, and sickle cell anemia after splenectomy" [http://www.clinlabnavigator.com/osmotic-fragility-of-red-blood-cells-unincubated-and-incubated.html, https://en.wikipedia.org/wiki/Erythrocyte_fragility, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased erythrocyte sensitivity to osmotic lysis" EXACT []
synonym: "increased erythrocyte resistance to osmotic lysis" EXACT []
synonym: "increased RBC resistance to osmotic lysis" EXACT []
synonym: "reduced erythrocyte osmotic fragility" EXACT []
synonym: "reduced red blood cell osmotic fragility" EXACT []
is_a: MP:0003657 ! abnormal erythrocyte osmotic lysis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T10:57:03Z" xsd:dateTime

[Term]
id: MP:0031085
name: increased erythrocyte osmotic fragility
def: "increased propensity of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions; seen in hereditary spherocytosis, some forms of hemolytic anemia, and hypernatremia" [https://en.wikipedia.org/wiki/Erythrocyte_fragility, https://medical-dictionary.thefreedictionary.com/osmotic+fragility, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased erythrocyte resistance to osmotic lysis" EXACT []
synonym: "decreased RBC resistance to osmotic lysis" EXACT []
synonym: "increased erythrocyte sensitivity to osmotic lysis" EXACT []
synonym: "increased red blood cell osmotic fragility" EXACT []
is_a: MP:0003657 ! abnormal erythrocyte osmotic lysis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T11:03:19Z" xsd:dateTime

[Term]
id: MP:0031086
name: wheezing
def: "a high-pitched whistling sound associated with labored breathing" [HP:0030828, PMID:26229557]
synonym: "wheeze" EXACT []
is_a: MP:0001950 ! abnormal respiratory sounds
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T11:36:17Z" xsd:dateTime

[Term]
id: MP:0031087
name: abnormal pneumocyte desquamation
def: "any anomaly in the shedding of alveolar epithelial cells into the alveolar space in response to infection/injury" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal desquamation of alveolar epithelial cells" EXACT []
synonym: "abnormal pneumonocyte desquamation" EXACT []
is_a: MP:0002273 ! abnormal pulmonary alveolus epithelial cell morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-11T12:03:19Z" xsd:dateTime

[Term]
id: MP:0031088
name: coughing
def: "a sudden expulsion of air through the large breathing passages that can help clear them of fluids, irritants, foreign particles and microbes; as a protective reflex, coughing can be repetitive with the cough reflex following three phases: an inhalation, a forced exhalation against a closed glottis, and a violent release of air from the lungs following opening of the glottis, usually accompanied by a distinctive sound" [HP:0012735, https://en.wikipedia.org/wiki/Cough]
synonym: "cough" EXACT []
synonym: "tussis" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T12:26:37Z" xsd:dateTime

[Term]
id: MP:0031089
name: sneezing
def: "a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa; a sneeze expels air forcibly from the mouth and nose in an explosive, audible, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane" [HP:0025095, https://en.wikipedia.org/wiki/Sneeze]
synonym: "sneeze" EXACT []
synonym: "sternutation" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T12:33:47Z" xsd:dateTime

[Term]
id: MP:0031090
name: ageusia
def: "complete absence or loss of the sense of taste, i.e. inability to detect sweetness, sourness, bitterness, saltiness, and umami (pleasant/savory taste)" [https://medical-dictionary.thefreedictionary.com/ageusia, https://www.slideshare.net/RizgarSaeed1/disturbances-of-taste-dysgeusia-hypogeusia-and-ageusia]
synonym: "ageustia" EXACT []
synonym: "gustatory anesthesia" EXACT []
is_a: MP:0001986 ! abnormal taste sensitivity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T16:02:26Z" xsd:dateTime

[Term]
id: MP:0031091
name: hypogeusia
def: "partial loss of taste or reduced ability to detect sweetness, sourness, bitterness, saltiness and/or umami (pleasant/savory taste); may be general to all tastants, partial to some tastants, or specific to one or more tastants" [https://medical-dictionary.thefreedictionary.com/hypogeusia]
synonym: "amblygeustia" EXACT []
synonym: "decreased taste sensitivity" EXACT []
synonym: "hypogeusesthesia" EXACT []
synonym: "partial loss of taste" EXACT []
synonym: "reduced taste sensitivity" EXACT []
is_a: MP:0001986 ! abnormal taste sensitivity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T16:14:54Z" xsd:dateTime

[Term]
id: MP:0031092
name: dysgeusia
def: "a distortion or an alteration in the perception of a tastant; an unpleasant perception may occur when a normally pleasant taste is present, or the perception may occur when no tastant is present" [https://medical-dictionary.thefreedictionary.com/dysgeusia]
synonym: "altered taste sensation" EXACT []
synonym: "distorted taste sensation" EXACT []
synonym: "parageusia" EXACT []
is_a: MP:0001985 ! abnormal gustatory system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T16:20:49Z" xsd:dateTime

[Term]
id: MP:0031093
name: multiple organ failure
def: "altered function in two or more organ systems during an acute illness such that homeostasis cannot be maintained without intervention" [https://litfl.com/multiple-organ-dysfunction-syndrome/]
synonym: "multi-organ failure" EXACT []
synonym: "multiple organ system failure" EXACT []
synonym: "multiple system organ failure" EXACT []
synonym: "multisystem organ failure" EXACT []
is_a: MP:0001764 ! abnormal homeostasis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T16:30:15Z" xsd:dateTime

[Term]
id: MP:0031094
name: organomegaly
def: "abnormal enlargement of one or more visceral organs (internal organs enclosed in a cavity) of the body" [https://orcid.org/0000-0002-6490-7723, ISBN:9780803609945]
is_a: MP:0005378 ! growth/size/body region phenotype
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-12T17:30:41Z" xsd:dateTime

[Term]
id: MP:0031095
name: pharyngitis
def: "local accumulation of fluid, plasma proteins and leukocytes in the pharynx, most often caused by viral or bacterial infections; less common causes include allergies, trauma, cancer, reflux, and certain toxins" [https://orcid.org/0000-0002-6490-7723, https://www.ncbi.nlm.nih.gov/books/NBK519550/]
synonym: "pharyngeal inflammation" EXACT []
synonym: "pharynx inflammation" EXACT []
synonym: "sore throat" RELATED []
is_a: MP:0002405 ! respiratory system inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T13:56:12Z" xsd:dateTime

[Term]
id: MP:0031096
name: conjunctival hyperemia
def: "abnormal dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera" [HP:0030953]
synonym: "conjunctival hyperaemia" EXACT []
synonym: "conjunctival injection" EXACT []
synonym: "conjunctival vascular congestion" EXACT []
is_a: MP:0006192 ! abnormal conjunctival vasculature morphology
is_a: MP:0031347 ! red eye
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T14:12:06Z" xsd:dateTime

[Term]
id: MP:0031097
name: conjunctival chemosis
def: "abnormal swelling (or edema) of the conjunctiva; in chemosis, the integrity of conjunctival capillaries is compromised, leading to increased permeability and leakage of serous fluid; causes include conjunctival irritation, infection, inflammation, trauma, and severe intraorbital inflammation" [HP:0012375, https://link.springer.com/referenceworkentry/10.1007%2F978-3-642-35951-4_765-1]
synonym: "conjunctival edema" EXACT []
synonym: "conjunctival oedema" EXACT []
is_a: MP:0001310 ! abnormal conjunctiva morphology
is_a: MP:0001785 ! edema
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T14:39:46Z" xsd:dateTime

[Term]
id: MP:0031098
name: abnormal sputum production
def: "any anomaly in the amount of material expectorated (coughed up) from the respiratory system; sputum is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin in disease states" [https://orcid.org/0000-0002-6490-7723, https://www.merriam-webster.com/dictionary/sputum]
synonym: "abnormal expectoration" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T14:53:04Z" xsd:dateTime

[Term]
id: MP:0031099
name: abnormal sputum morphology
def: "any anomaly in the gross appearance or other physical characteristics of sputum, that is, the material expectorated (coughed up) from the respiratory system, including its color, consistency, taste, and smell; sputum is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin in disease states" [https://www.merriam-webster.com/dictionary/sputum, https://www.ncbi.nlm.nih.gov/books/NBK359/]
is_a: MP:0002132 ! abnormal respiratory system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T15:08:03Z" xsd:dateTime

[Term]
id: MP:0031100
name: hemoptysis
def: "expectoration (coughing up) of blood or blood-tinged sputum from the lungs or tracheobronchial tree" [https://www.ncbi.nlm.nih.gov/books/NBK360/]
synonym: "bloody sputum" RELATED []
synonym: "coughing up blood or blood-stained mucus" RELATED []
synonym: "coughing up of blood" EXACT []
synonym: "expectoration of blood" EXACT []
synonym: "expectoration of blood-stained sputum" EXACT []
synonym: "haemoptysis" EXACT []
is_a: MP:0031099 ! abnormal sputum morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T15:27:40Z" xsd:dateTime

[Term]
id: MP:0031101
name: nasal obstruction
def: "a blockage within the nasal cavity, resulting in insufficient airflow through the nose; causes of obstruction include swelling of the mucous membrane (nasal congestion), nasal polyps, nasopharyngeal carcinoma or foreign bodies" [https://medical-dictionary.thefreedictionary.com/nasal+obstruction, https://www.uptodate.com/contents/nasal-obstruction-diagnosis-and-management]
synonym: "blockage of nose" EXACT []
synonym: "nasal blockage" EXACT []
synonym: "obstruction of nose" EXACT []
is_a: MP:0002237 ! abnormal nasal cavity morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T15:42:46Z" xsd:dateTime

[Term]
id: MP:0031102
name: rhinorrhea
def: "increased discharge of fluid (typically a watery mucus fluid) from the nose; a common symptom of allergies or certain viral infections" [https://www.lexico.com/definition/rhinorrhoea, https://www.mayoclinic.org/symptoms/runny-nose/basics/definition/sym-20050640]
synonym: "fluid dripping from the nose" EXACT []
synonym: "rhinorrhoea" EXACT []
synonym: "runny nose" EXACT []
is_a: MP:0002133 ! abnormal respiratory system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-17T15:59:48Z" xsd:dateTime

[Term]
id: MP:0031103
name: skin rash
def: "an eruption in the skin which affects its appearance and/or texture; a rash may be localized to one part of the body, or affect all the skin; rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful" [NCIT:C39594]
synonym: "cutaneous eruption" EXACT []
synonym: "skin eruption" EXACT []
is_a: MP:0001191 ! abnormal skin condition
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T10:58:11Z" xsd:dateTime

[Term]
id: MP:0031104
name: crackles
def: "fine, short, high-pitched, intermittently crackling sounds heard in a lung field that has fluid in the small airways; crackles are commonly heard in the bases of the lung lobes during inspiration; the cause of crackles can be from air passing through fluid, pus or mucus; crackles can be further categorised as coarse or fine: the sound quality of fine crackles is similar to the sound of hair rubbed between your fingers near the ear and may be heard in congestive heart failure and pulmonary fibrosis; coarse crackles are lower-pitched and moist-sounding, like pouring water out of a bottle or ripping open velcro, and are often a sign of adult respiratory distress syndrome (ARDS), early congestive heart failure, asthma and pulmonary edema" [https://www.ausmed.com/cpd/articles/rhonchi-vs-rales-wheezing-crackles]
synonym: "alveolar rales" NARROW []
synonym: "crepitations" EXACT []
synonym: "rales" EXACT []
is_a: MP:0001950 ! abnormal respiratory sounds
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T11:17:02Z" xsd:dateTime

[Term]
id: MP:0031105
name: rhonchi
def: "continuous low-pitched, rattling lung sounds that often resemble snoring, frequently caused by obstruction or secretions in larger airways; they can be heard in chronic obstructive pulmonary disease (COPD), bronchiectasis, pneumonia, chronic bronchitis, or cystic fibrosis" [https://www.easyauscultation.com/rhonchi]
synonym: "rhonchus" EXACT []
is_a: MP:0001950 ! abnormal respiratory sounds
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T11:23:24Z" xsd:dateTime

[Term]
id: MP:0031106
name: abnormal susceptibility to pulmonary hyaline membrane formation
def: "a change in the likelihood that an organism will form an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles" [https://orcid.org/0000-0002-6490-7723]
synonym: "altered susceptibility to pulmonary hyaline membrane formation" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T11:43:24Z" xsd:dateTime

[Term]
id: MP:0031107
name: abnormal circulating myoglobin level
def: "anomaly in the blood level of myoglobin, a low molecular weight oxygen binding heme protein that is normally found exclusively in heart and skeletal muscle cells; in blood, myoglobin is bound primarily to plasma globulins, a complex which is filtered by the kidneys; if the plasma concentration exceeds the plasma binding capacity, myoglobin begins to appear in the urine; monitoring myoglobin levels in blood (and urine) has been used as a means to detect skeletal or cardiac muscle cell injury" [ISBN:9780124157590]
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T13:04:49Z" xsd:dateTime

[Term]
id: MP:0031108
name: increased circulating myoglobin level
def: "increased blood level of myoglobin, a low molecular weight oxygen binding heme protein that is normally found exclusively in heart and skeletal muscle cells; in blood, myoglobin is bound primarily to plasma globulins, a complex which is filtered by the kidneys; if the plasma concentration exceeds the plasma binding capacity, myoglobin begins to appear in the urine; myoglobin is rapidly released into the bloodstream after muscle damage, and thus can be a useful biomarker in the early phases of heart or skeletal muscle injury" [ISBN:9780124157590]
synonym: "elevated blood myoglobin level" EXACT []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031107 ! abnormal circulating myoglobin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-22T13:11:41Z" xsd:dateTime

[Term]
id: MP:0031109
name: subarachnoid hemorrhage
def: "bleeding into the space between the arachnoid mater and the pia mater" [HP:0002138]
synonym: "subarachnoid haemorrhage" EXACT []
synonym: "subarachnoid space haemorrhage" EXACT []
synonym: "subarachnoid space hemorrhage" EXACT []
is_a: MP:0001915 ! intracranial hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-30T08:32:31Z" xsd:dateTime

[Term]
id: MP:0031110
name: meningitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the protective membranes (meninges) covering the brain and spinal cord, commonly caused by a bacterial or viral infection" [https://en.wikipedia.org/wiki/Meningitis, https://orcid.org/0000-0002-6490-7723]
synonym: "inflammation of the meninges" EXACT []
synonym: "meningeal inflammation" EXACT []
is_a: MP:0006082 ! CNS inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-30T10:09:04Z" xsd:dateTime

[Term]
id: MP:0031111
name: meningoencephalitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in the brain and its surrounding protective membranes (meninges)" [https://medical-dictionary.thefreedictionary.com/meningoencephalitis, https://orcid.org/0000-0002-6490-7723]
synonym: "encephalomeningitis" EXACT []
is_a: MP:0006082 ! CNS inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-06-30T10:22:05Z" xsd:dateTime

[Term]
id: MP:0031112
name: rhabdomyolysis
def: "breakdown of skeletal muscle fibers leading to leakage of muscle contents into the bloodstream; damage to the sarcolemma results in loss of its intrinsic function, an influx of calcium, activation of intracellular proteases, and release of intracellular contents (e.g. myoglobin, creatine phosphokinase, aldolase, lactate dehydrogenase, aspartate transaminase, and potassium) into the circulation; common causes include trauma, prolonged exertion, hyperthermia, infections, electrolyte abnormalities, electrical current injury, drugs or toxins, and conditions that cause tissue hypoxia; complications may include acute renal failure, metabolic abnormalities, and disseminated intravascular congestion" [https://www.aafp.org/afp/2002/0301/p907.html, ISBN:978-1-4160-2971-7]
is_a: MP:0000759 ! abnormal skeletal muscle morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-07-07T10:04:24Z" xsd:dateTime

[Term]
id: MP:0031113
name: pulmonary parenchymal consolidation
def: "replacement of alveolar air by fluid (exudate/transudate/blood), cells (inflammatory), tissue, or other material, rendering the pulmonary parenchyma airless; consolidated tissue is more radio-opaque than normally aerated lung parenchyma, so that it is clearly demonstrable in radiography and on CT scans" [doi:10.1097/CPM.0b013e3182a2b140, https://en.wikipedia.org/wiki/Pulmonary_consolidation#Radiology, https://radiologykey.com/consolidation-and-atelectasis/, https://radiopaedia.org/articles/lobar-consolidation]
synonym: "lung parenchymal consolidation" EXACT []
synonym: "pulmonary consolidation" BROAD []
is_a: MP:0001175 ! abnormal lung morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-07-07T10:54:12Z" xsd:dateTime

[Term]
id: MP:0031114
name: increased circulating gamma-glutamyl transferase level
def: "elevated blood level of the enzyme that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate); GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification; GGT is present in many organs throughout the body, with the highest concentrations found in liver, and elevated in the blood in most diseases that cause damage to the liver or bile ducts" [https://en.wikipedia.org/wiki/Gamma-glutamyltransferase, https://labtestsonline.org/tests/gamma-glutamyl-transferase-ggt]
synonym: "increased circulating gamma-glutamyl transpeptidase level" EXACT []
synonym: "increased circulating gamma-GT level" EXACT []
synonym: "increased circulating GGT level" EXACT []
is_a: MP:0014450 ! increased circulating enzyme level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-07-07T11:27:05Z" xsd:dateTime

[Term]
id: MP:0031115
name: macrovesicular hepatic steatosis
def: "a common form of hepatic steatosis characterized by the presence of large lipid droplets that displace the nucleus and organelles to the cell periphery in affected hepatocytes; may be caused by oversupply of lipids due to obesity, obstructive sleep apnea, insulin resistance, or alcoholism" [https://en.wikipedia.org/wiki/Steatosis, ISBN:978-0-323-37591-7]
synonym: "large droplet steatosis" EXACT []
synonym: "macrovesicular steatosis" EXACT []
is_a: MP:0002628 ! hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-07-07T12:25:03Z" xsd:dateTime

[Term]
id: MP:0031116
name: microvesicular hepatic steatosis
def: "a less common form of hepatic steatosis characterized by accumulation of multiple small lipid droplets giving the cytoplasm a foamy appearance without displacing the nucleus in affected hepatocytes; causes include tetracyclines, acute fatty liver of pregnancy, Reye's syndrome, and hepatitis C" [https://en.wikipedia.org/wiki/Steatosis, ISBN:978-0-323-37591-7]
synonym: "microvesicular steatosis" EXACT []
synonym: "small droplet steatosis" EXACT []
is_a: MP:0002628 ! hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-07-07T12:29:33Z" xsd:dateTime

[Term]
id: MP:0031117
name: subdural hemorrhage
def: "bleeding into the subdural space, the potential space between the dura and arachnoid mater of the meninges around the brain" [HP:0100309, https://radiopaedia.org/articles/subdural-haemorrhage]
synonym: "subdural haematoma" RELATED []
synonym: "subdural haemorrhage" EXACT []
synonym: "subdural hematoma" RELATED []
is_a: MP:0001915 ! intracranial hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T06:14:55Z" xsd:dateTime

[Term]
id: MP:0031118
name: cardiovalvulitis
def: "local accumulation of fluid, plasma proteins, and leukocytes in one or more valves of the heart" [https://medical-dictionary.thefreedictionary.com/cardiovalvulitis]
synonym: "cardiac valve inflammation" EXACT []
synonym: "cardiac valvulitis" EXACT []
synonym: "cardial valve inflammation" EXACT []
synonym: "heart valve inflammation" EXACT []
synonym: "heart valvulitis" EXACT []
synonym: "inflammation of the cardiac valves" EXACT []
synonym: "inflammation of the heart valves" EXACT []
is_a: MP:0001853 ! heart inflammation
is_a: MP:0011926 ! abnormal heart valve physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T06:39:20Z" xsd:dateTime

[Term]
id: MP:0031119
name: pulmonary cavitation
def: "presence of an abnormal gas-filled space within a zone of pulmonary consolidation or within a pulmonary mass or nodule appearing as a lucency or low-attenuation area on plain chest radiography or computed tomography; a pulmonary cavity may contain a fluid level and is surrounded by a wall, usually of varied thickness" [https://radiopaedia.org/articles/pulmonary-cavitation, PMID:18400799]
synonym: "abnormal lung cavities" EXACT []
synonym: "abnormal pulmonary cavities" EXACT []
synonym: "cavitary lung lesion(s)" EXACT []
synonym: "lung cavitation" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T07:13:19Z" xsd:dateTime

[Term]
id: MP:0031120
name: decreased susceptibility to induced thrombosis
def: "decreased frequency, rate or severity of thrombus formation following stimulation of thrombosis by an external agent" [https://orcid.org/0000-0002-6490-7723]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "increased resistance to induced thrombosis" EXACT []
synonym: "reduced susceptibility to induced thrombosis" EXACT []
is_a: MP:0020408 ! abnormal susceptibility to induced thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T09:50:39Z" xsd:dateTime

[Term]
id: MP:0031121
name: increased susceptibility to induced thrombosis
def: "increased frequency, rate or severity of thrombus formation following stimulation of thrombosis by an external agent" [https://orcid.org/0000-0002-6490-7723]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "decreased resistance to induced thrombosis" EXACT []
is_a: MP:0020408 ! abnormal susceptibility to induced thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T10:04:30Z" xsd:dateTime

[Term]
id: MP:0031122
name: areflexia
def: "complete absence or loss of neurological reflexes" [https://www.merriam-webster.com/medical/areflexia, ISBN:9781786842961]
synonym: "absence of reflexes" EXACT []
synonym: "absent reflexes" EXACT []
is_a: MP:0001961 ! abnormal reflex
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T10:30:49Z" xsd:dateTime

[Term]
id: MP:0031123
name: abnormal anterior longitudinal ligament morphology
def: "any structural anomaly of the strong, broad fibrous band that covers and connects the anterolateral aspects of the vertebral bodies and intervertebral (IV) discs; this ligament extends from the pelvic surface of the sacrum to the anterior tubercle of vertebra C1 (atlas) and the occipital bone anterior to the foramen magnum; it prevents hyperflexion of the vertebral column, maintaining stability of the joints between the vertebral bodies; it is the only ligament that limits extension; all other ligaments of the vertebral column, like the IV ligaments, limit forms of flexion" [https://www.kenhub.com/en/library/anatomy/joints-and-ligaments-of-the-vertebral-column]
is_a: MP:0004703 ! abnormal vertebral column morphology
is_a: MP:0005504 ! abnormal ligament morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-25T14:01:06Z" xsd:dateTime

[Term]
id: MP:0031124
name: aortic valve inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the aortic valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic semi-lunar valve inflammation" EXACT []
synonym: "aortic semilunar valve inflammation" EXACT []
synonym: "left arterial valve inflammation" EXACT []
synonym: "left semi-lunar valve inflammation" EXACT []
synonym: "left semilunar valve inflammation" EXACT []
synonym: "left ventriculoarterial junction inflammation" EXACT []
is_a: MP:0031118 ! cardiovalvulitis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-31T09:14:02Z" xsd:dateTime

[Term]
id: MP:0031125
name: aspiration pneumonia
def: "pneumonia occurring after abnormal entry of material from the oral cavity or upper gastrointestinal tract into the lungs through the larynx; aspirated material can include saliva, nasopharyngeal secretions, bacteria, liquids, toxic substances, food, or gastric contents; can result in pulmonary complications by way of chemical pneumonitis, bacterial infection, or mechanical obstruction" [HP:0011951, PMID:28879323]
is_a: MP:0001861 ! lung inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-31T09:32:28Z" xsd:dateTime

[Term]
id: MP:0031126
name: gangrene
def: "necrosis or death of soft tissue due to lack of blood flow resulting from injury, infection or other conditions that affect blood circulation" [HP:0100758, https://my.clevelandclinic.org/health/diseases/21070-gangrene, https://www.dictionary.com/browse/gangrene]
synonym: "gangrenous necrosis" EXACT []
is_a: MP:0000316 ! cellular necrosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-31T10:40:52Z" xsd:dateTime

[Term]
id: MP:0031127
name: dry gangrene
def: "a form of coagulative necrosis that develops in ischemic tissue, where the blood supply is inadequate to keep tissue viable, in the absence of superimposed microbial infection; can be due to peripheral artery disease or acute limb ischemia; the affected body part is dry, shrunken, and dark reddish-black and can fall off (autoamputate) if not removed surgically" [http://www.pathwaymedicine.org/gangrenous-necrosis, https://en.wikipedia.org/wiki/Gangrene#Dry_gangrene]
comment: The term dry is used only when referring to a limb or to the gut; in other locations, this same type of necrosis is called an infarction, such as myocardial infarction {xref="https://en.wikipedia.org/wiki/Gangrene#Dry_gangrene"}
is_a: MP:0031126 ! gangrene
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-08-31T10:58:35Z" xsd:dateTime

[Term]
id: MP:0031128
name: cardiovascular shunt
def: "an abnormal communication (shunt) between the right and left sides of the heart or between the systemic and pulmonary vessels, allowing blood to flow directly from one circulatory system to the other; blood can either be shunted from the systemic circulation to pulmonary circulation (i.e. left-to-right shunt) or between the pulmonary circulation and systemic circulation (i.e. right-to-left shunt); rarely, the shunted blood returns to the same cardiac chamber without traversing a capillary bed (i.e. circular shunt); most commonly shunts are the result of congenital heart disease" [https://radiopaedia.org/articles/cardiovascular-shunts]
synonym: "cardiac shunt" NARROW []
is_a: MP:0002128 ! abnormal blood circulation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T06:43:51Z" xsd:dateTime

[Term]
id: MP:0031129
name: left-to-right shunt
def: "a left-to-right shunt allows the oxygenated, pulmonary venous blood to return directly to the lungs rather than being pumped to the body thereby reducing the cardiac output by the amount of the shunted volume; as a result, tissue oxygen delivery is reduced" [PMID:18299514]
synonym: "L-R shunt" EXACT []
synonym: "left-to-right shunting" EXACT []
is_a: MP:0031128 ! cardiovascular shunt
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T06:55:18Z" xsd:dateTime

[Term]
id: MP:0031130
name: right-to-left shunt
def: "a right-to-left shunt allows the deoxygenated, systemic venous return to bypass the lungs and return directly to the systemic arterial circulation; the oxygen content of the systemic arterial blood falls in proportion to the volume of systemic venous blood mixing with the normal pulmonary venous return; with reduced oxygen content, even with normal cardiac output, tissue oxygen delivery falls and the work capacity of muscles is limited" [PMID:18299514]
synonym: "R-L shunt" EXACT []
synonym: "right-to-left shunting" EXACT []
is_a: MP:0031128 ! cardiovascular shunt
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T06:59:53Z" xsd:dateTime

[Term]
id: MP:0031131
name: myocardial fiber disarray
def: "loss of the normal parallel alignment of cardiac myocytes, whereby adjacent myocytes are arranged obliquely or perpendicularly to each other around foci of interstitial collagen (plexiform fibrosis) in a pinwheel or herringbone pattern; disarray is characterized by regions of architectural disorganization of hypertrophied myocytes and distinct nuclear changes" [https://doi.org/10.15420/ecr.2010.6.2.88, PMID:15657260, PMID:7890275]
comment: Myocardial fiber disarray is not specific for hypertrophic cardiomyopathy (HCM); this architectural disorganization of cardiac myocytes has been found, although to a lesser extent, in dilated cardiomyopathy (CM), alcoholic CM, various congenital heart diseases and cardiovascular diseases (systemic hypertension, coronary artery disease and cor pulmonale) and in normal hearts {xref="https://doi.org/10.15420/ecr.2010.6.2.88"}
synonym: "adult cardiomyocyte disarray" EXACT []
synonym: "cardiac myocyte disarray" EXACT []
synonym: "myocardial cell disarray" EXACT []
synonym: "myocardial disarray" BROAD []
synonym: "myocardial fibre disarray" EXACT []
is_a: MP:0000278 ! abnormal myocardial fiber morphology
is_a: MP:0002190 ! disorganized myocardium
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T08:39:34Z" xsd:dateTime

[Term]
id: MP:0031132
name: increased artery tortuosity
def: "increase in the degree of twisting of one or more arteries" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased arterial tortuosity" EXACT []
synonym: "tortuous arteries" EXACT []
is_a: MP:0002191 ! abnormal artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T10:26:58Z" xsd:dateTime

[Term]
id: MP:0031133
name: increased aorta tortuosity
def: "increase in the degree of twisting of the aorta" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased aortic tortuosity" EXACT []
synonym: "tortuous aorta" EXACT []
is_a: MP:0000272 ! abnormal aorta morphology
is_a: MP:0031132 ! increased artery tortuosity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T10:37:01Z" xsd:dateTime

[Term]
id: MP:0031134
name: increased carotid artery tortuosity
def: "increase in the degree of twisting of the common carotid artery and/or any of its arterial branches" [https://orcid.org/0000-0002-6490-7723]
synonym: "tortuous carotid artery" EXACT []
is_a: MP:0004181 ! abnormal carotid artery morphology
is_a: MP:0031132 ! increased artery tortuosity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T10:42:40Z" xsd:dateTime

[Term]
id: MP:0031135
name: increased coronary artery tortuosity
def: "increase in the degree of twisting of any of the arteries that branch from the ascending aorta to supply blood to the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "tortuous coronary artery" EXACT []
is_a: MP:0004111 ! abnormal coronary artery morphology
is_a: MP:0031132 ! increased artery tortuosity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T10:49:32Z" xsd:dateTime

[Term]
id: MP:0031136
name: muscle hemorrhage
def: "bleeding into one or more muscles" [https://orcid.org/0000-0002-6490-7723]
synonym: "intramuscular haemorrhage" EXACT []
synonym: "intramuscular hemorrhage" EXACT []
synonym: "muscle haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0002106 ! abnormal muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T11:04:37Z" xsd:dateTime

[Term]
id: MP:0031137
name: vaginal hemorrhage
def: "bleeding into the vagina" [https://orcid.org/0000-0002-6490-7723]
synonym: "vagina haemorrhage" EXACT []
synonym: "vagina hemorrhage" EXACT []
synonym: "vaginal bleeding" EXACT []
synonym: "vaginal haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0004245 ! genital hemorrhage
is_a: MP:0031162 ! abnormal vagina physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T11:26:37Z" xsd:dateTime

[Term]
id: MP:0031138
name: testicular hemorrhage
def: "bleeding into one or both testes" [https://orcid.org/0000-0002-6490-7723]
synonym: "intratesticular haemorrhage" EXACT []
synonym: "intratesticular hemorrhage" EXACT []
synonym: "testes haemorrhage" EXACT []
synonym: "testes hemorrhage" EXACT []
synonym: "testicular haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0004245 ! genital hemorrhage
is_a: MP:0004884 ! abnormal testis physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T11:41:24Z" xsd:dateTime

[Term]
id: MP:0031139
name: abnormal retina artery morphology
def: "any structural anomaly of the central retinal artery that branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball; this artery provides the majority of the retinal arterial supply except for the layer of cones and rods; it splits into multiple terminal branches within the ninth layer of retina, which then comprise a cobweb of retinal arterioles and capillaries that nourishes the inner retinal layers" [https://en.wikipedia.org/wiki/Central_retinal_artery, https://www.kenhub.com/en/library/anatomy/central-retinal-artery]
synonym: "abnormal central retinal artery morphology" EXACT []
synonym: "abnormal retinal artery morphology" EXACT []
synonym: "abnormal Zinn artery morphology" EXACT []
is_a: MP:0010097 ! abnormal retina blood vessel morphology
is_a: MP:0011655 ! abnormal systemic artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T12:08:36Z" xsd:dateTime

[Term]
id: MP:0031140
name: increased retina artery tortuosity
def: "increase in the degree of twisting of the retinal artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased central retinal artery tortuosity" EXACT []
synonym: "increased retinal arterial tortuosity" EXACT []
synonym: "increased retinal artery tortuosity" EXACT []
synonym: "tortuous retinal arteries" EXACT []
is_a: MP:0031132 ! increased artery tortuosity
is_a: MP:0031139 ! abnormal retina artery morphology
is_a: MP:0031141 ! increased retina vascular tortuosity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T12:24:29Z" xsd:dateTime

[Term]
id: MP:0031141
name: increased retina vascular tortuosity
def: "increase in the degree of twisting of any of the retinal blood vessels" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased retinal vascular tortuosity" EXACT []
synonym: "tortuous retinal blood vessels" EXACT []
is_a: MP:0010097 ! abnormal retina blood vessel morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T12:30:27Z" xsd:dateTime

[Term]
id: MP:0031142
name: retina artery stenosis
def: "abnormal narrowing or constriction of the retinal artery" [https://orcid.org/0000-0002-6490-7723]
synonym: "central retinal artery stenosis" EXACT []
synonym: "constricted retinal artery" EXACT []
synonym: "narrowed retinal artery" EXACT []
synonym: "retinal arterial stenosis" EXACT []
synonym: "retinal artery stenosis" EXACT []
is_a: MP:0006135 ! artery stenosis
is_a: MP:0031139 ! abnormal retina artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T12:44:50Z" xsd:dateTime

[Term]
id: MP:0031143
name: retina artery occlusion
def: "blockage of the retinal artery, generally associated with interruption of blood flow and oxygen delivery to the retina" [HP:0025326]
synonym: "blocked retinal artery" EXACT []
synonym: "central retinal artery occlusion" EXACT []
synonym: "retinal arterial occlusion" EXACT []
synonym: "retinal artery occlusion" EXACT []
is_a: MP:0006134 ! artery occlusion
is_a: MP:0031139 ! abnormal retina artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T12:52:44Z" xsd:dateTime

[Term]
id: MP:0031144
name: abnormal retina arteriole morphology
def: "any structural anomaly of any of the retinal arterioles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal retinal arteriole morphology" EXACT []
is_a: MP:0004112 ! abnormal arteriole morphology
is_a: MP:0010097 ! abnormal retina blood vessel morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T13:35:09Z" xsd:dateTime

[Term]
id: MP:0031145
name: retina arteriole stenosis
def: "abnormal narrowing or constriction of any of the retinal arterioles" [https://orcid.org/0000-0002-6490-7723]
synonym: "constricted retinal arterioles" EXACT []
synonym: "narrowed retinal arterioles" EXACT []
synonym: "retinal arteriolar stenosis" EXACT []
synonym: "retinal arteriole stenosis" EXACT []
is_a: MP:0031144 ! abnormal retina arteriole morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T13:42:35Z" xsd:dateTime

[Term]
id: MP:0031146
name: retina arteriole occlusion
def: "blockage of any of the retinal arterioles, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina" [HP:0007985]
synonym: "blocked retinal arterioles" EXACT []
synonym: "retinal arteriolar occlusion" EXACT []
synonym: "retinal arteriole occlusion" EXACT []
is_a: MP:0031144 ! abnormal retina arteriole morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-11T13:51:45Z" xsd:dateTime

[Term]
id: MP:0031147
name: abnormal ventricular thrombosis
def: "any anomaly in the formation or presence of one or more thrombi in the ventricles of the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac ventricular thrombosis" EXACT []
synonym: "abnormal heart ventricle thrombosis" EXACT []
synonym: "abnormal heart ventricular thrombosis" EXACT []
is_a: MP:0020409 ! abnormal cardiac thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T08:49:52Z" xsd:dateTime

[Term]
id: MP:0031148
name: abnormal liver sinusoidal endothelial cell morphology
def: "any structural anomaly of the endothelial cells that line the hepatic sinusoids, constituting the sinusoidal wall; these represent the most abundant non-parenchymal hepatic cell population, are characterized by the presence of fenestrae clustered in sieve plates and lacking a basement membrane, play roles in filtration, endocytosis, antigen presentation and leukocyte recruitment, and in combination with Kupffer cells, constitute a scavenger system in the body" [PMID:12437787, PMID:29844586]
synonym: "abnormal hepatic sinusoidal endothelial cell morphology" EXACT []
synonym: "abnormal HSEC morphology" EXACT []
synonym: "abnormal LSEC morphology" EXACT []
is_a: MP:0006055 ! abnormal vascular endothelial cell morphology
is_a: MP:0008989 ! abnormal liver sinusoid morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T12:51:34Z" xsd:dateTime

[Term]
id: MP:0031149
name: abnormal susceptibility to thrombosis induced morbidity/mortality
def: "differences from the expected moribund state caused by thrombus formation following stimulation of thrombosis by an external agent" [https://orcid.org/0000-0002-6490-7723]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "abnormal resistance to thrombosis induced morbidity/mortality" EXACT []
synonym: "abnormal sensitivity to thrombosis induced morbidity/mortality" EXACT []
synonym: "altered susceptibility to thrombosis induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0020408 ! abnormal susceptibility to induced thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T13:52:41Z" xsd:dateTime

[Term]
id: MP:0031150
name: decreased susceptibility to thrombosis induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by thrombus formation following stimulation of thrombosis by an external agent" [https://orcid.org/0000-0002-6490-7723]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "decreased sensitivity to thrombosis induced morbidity/mortality" EXACT []
synonym: "increased resistance to thrombosis induced morbidity/mortality" EXACT []
is_a: MP:0031120 ! decreased susceptibility to induced thrombosis
is_a: MP:0031149 ! abnormal susceptibility to thrombosis induced morbidity/mortality
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T13:56:17Z" xsd:dateTime

[Term]
id: MP:0031151
name: increased susceptibility to thrombosis induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by thrombus formation following stimulation of thrombosis by an external agent" [https://orcid.org/0000-0002-6490-7723]
comment: This term should be used in conjunction with any mechanical, chemical, physical or infectious agent that induces thrombus formation.
synonym: "decreased resistance to thrombosis induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to thrombosis induced morbidity/mortality" EXACT []
is_a: MP:0031121 ! increased susceptibility to induced thrombosis
is_a: MP:0031149 ! abnormal susceptibility to thrombosis induced morbidity/mortality
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T13:59:57Z" xsd:dateTime

[Term]
id: MP:0031152
name: subcutaneous hemorrhage
def: "bleeding below the skin" [HP:0001933]
synonym: "bleeding underneath the skin" EXACT []
synonym: "subcutaneous bleeding" EXACT []
synonym: "subcutaneous haemorrhage" EXACT []
is_a: MP:0001634 ! internal hemorrhage
is_a: MP:0010680 ! abnormal skin adnexa physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-14T16:04:16Z" xsd:dateTime

[Term]
id: MP:0031153
name: stomach hemorrhage
def: "bleeding into the stomach" [https://orcid.org/0000-0002-6490-7723]
synonym: "gastric bleeding" EXACT []
synonym: "gastric haemorrhage" EXACT []
synonym: "gastric hemorrhage" EXACT []
synonym: "stomach bleeding" EXACT []
synonym: "stomach haemorrhage" EXACT []
is_a: MP:0000465 ! gastrointestinal hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T09:24:48Z" xsd:dateTime

[Term]
id: MP:0031154
name: intestinal hemorrhage
def: "bleeding into any segment of the small intestine and/or the large intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "intestinal bleeding" EXACT []
synonym: "intestinal haemorrhage" EXACT []
synonym: "intestine haemorrhage" EXACT []
synonym: "intestine hemorrhage" EXACT []
is_a: MP:0000465 ! gastrointestinal hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T09:30:55Z" xsd:dateTime

[Term]
id: MP:0031155
name: small intestine hemorrhage
def: "bleeding into any segment of the small intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "small intestinal bleeding" EXACT []
synonym: "small intestinal haemorrhage" EXACT []
synonym: "small intestinal hemorrhage" EXACT []
synonym: "small intestine bleeding" EXACT []
synonym: "small intestine haemorrhage" EXACT []
is_a: MP:0031154 ! intestinal hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T09:36:14Z" xsd:dateTime

[Term]
id: MP:0031156
name: large intestine hemorrhage
def: "bleeding into any segment the large intestine" [https://orcid.org/0000-0002-6490-7723]
synonym: "large intestinal bleeding" EXACT []
synonym: "large intestinal haemorrhage" EXACT []
synonym: "large intestinal hemorrhage" EXACT []
synonym: "large intestine bleeding" EXACT []
synonym: "large intestine haemorrhage" EXACT []
is_a: MP:0031154 ! intestinal hemorrhage
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T09:41:55Z" xsd:dateTime

[Term]
id: MP:0031157
name: abnormal arterial thrombosis
def: "any anomaly in the formation or presence of thrombi inside one or more arteries, causing the obstruction of blood flow" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal artery thrombosis" EXACT []
synonym: "blood clot in one or more arteries" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T10:28:07Z" xsd:dateTime

[Term]
id: MP:0031158
name: abnormal venous thrombosis
def: "any anomaly in the formation or presence of thrombi inside one or more veins, causing the obstruction of blood flow" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vein thrombosis" EXACT []
synonym: "blood clot in one or more veins" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T11:23:34Z" xsd:dateTime

[Term]
id: MP:0031159
name: abnormal hepatic portal vein thrombosis
def: "any anomaly in the formation or presence of thrombi inside the hepatic portal vein and/or its tributaries, which include the splenic vein and the superior and inferior mesenteric veins" [https://orcid.org/0000-0002-6490-7723]
synonym: "blood clot in hepatic portal vein" EXACT []
is_a: MP:0031158 ! abnormal venous thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T11:26:07Z" xsd:dateTime

[Term]
id: MP:0031160
name: abnormal cerebral venous thrombosis
def: "any anomaly in the formation or presence of thrombi inside any cerebral vein, causing the obstruction of blood flow" [HP:0005305, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cerebral vein thrombosis" EXACT []
synonym: "blood clot in cerebral vein" EXACT []
is_a: MP:0031158 ! abnormal venous thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T11:30:40Z" xsd:dateTime

[Term]
id: MP:0031161
name: abnormal kidney venous thrombosis
def: "any anomaly in the formation or presence of thrombi inside any kidney venous blood vessel, causing the obstruction of blood flow" [https://orcid.org/0000-0002-6490-7723]
synonym: "blood clot in kidney venous blood vessel" EXACT []
is_a: MP:0011507 ! abnormal kidney thrombosis
is_a: MP:0031158 ! abnormal venous thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T11:33:53Z" xsd:dateTime

[Term]
id: MP:0031162
name: abnormal vagina physiology
def: "any functional anomaly of the fibromuscular tubular tract leading from the uterus to the exterior of the body; it serves as a passageway for cervical mucus, menstrual fluid and other secretions out of the body; during sexual intercourse, it receives the penis and ejaculate, assisting in its transport to the uterus; during the birth process, it expands to provide a channel for delivery of a newborn from the uterus" [https://teachmeanatomy.info/pelvis/female-reproductive-tract/vagina/, https://www.verywellhealth.com/what-is-the-vagina-2616563]
synonym: "abnormal vaginal physiology" EXACT []
is_a: MP:0003699 ! abnormal female reproductive system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-15T14:46:14Z" xsd:dateTime

[Term]
id: MP:0031163
name: abnormal circulating von Willebrand factor level
def: "any anomaly in the blood level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall" [PMID:29507883]
synonym: "abnormal circulating VWF level" EXACT []
synonym: "abnormal circulating vWF level" EXACT []
synonym: "abnormal plasma von Willebrand factor level" NARROW []
synonym: "abnormal plasma VWF level" NARROW []
synonym: "abnormal plasma vWF level" NARROW []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-21T10:08:42Z" xsd:dateTime

[Term]
id: MP:0031164
name: decreased circulating von Willebrand factor level
def: "reduced blood level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall" [https://orcid.org/0000-0002-6490-7723, PMID:29507883]
synonym: "decreased plasma von Willebrand factor level" NARROW []
synonym: "decreased plasma VWF level" NARROW []
synonym: "decreased plasma vWF level" NARROW []
synonym: "reduced circulating VWF level" EXACT []
synonym: "reduced circulating vWF level" EXACT []
synonym: "reduced plasma von Willebrand factor level" NARROW []
synonym: "reduced plasma VWF level" NARROW []
synonym: "reduced plasma vWF level" NARROW []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031163 ! abnormal circulating von Willebrand factor level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-21T10:24:39Z" xsd:dateTime

[Term]
id: MP:0031165
name: increased circulating von Willebrand factor level
def: "elevated blood level of the large multimeric glycoprotein produced by vascular endothelial cells and megakaryocytes that chaperones blood coagulation cofactor factor VIII and tethers platelets to the injured blood vessel wall" [https://orcid.org/0000-0002-6490-7723, PMID:29507883]
synonym: "increased circulating VWF level" EXACT []
synonym: "increased circulating vWF level" EXACT []
synonym: "increased plasma von Willebrand factor level" NARROW []
synonym: "increased plasma VWF level" NARROW []
synonym: "increased plasma vWF level" NARROW []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031163 ! abnormal circulating von Willebrand factor level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-21T10:30:09Z" xsd:dateTime

[Term]
id: MP:0031166
name: abnormal aortic valve commissure morphology
def: "any structural anomaly of the space or area between each anchored aortic valve leaflet to the aortic wall; the aortic valve is composed of 3 commissures that act as support to the base structure of the cusps" [https://www.cardioserv.net/echo-aortic-valve-anatomy/]
is_a: MP:0002747 ! abnormal aortic valve morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-23T09:34:29Z" xsd:dateTime

[Term]
id: MP:0031167
name: abnormal lung thrombosis
def: "any anomaly in the formation or presence of one or more thrombi within the blood vessel network of the lung" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pulmonary thrombosis" EXACT []
is_a: MP:0005048 ! abnormal thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-23T10:00:46Z" xsd:dateTime

[Term]
id: MP:0031168
name: abnormal brain thrombosis
def: "any anomaly in the formation or presence of one or more thrombi within the blood vessel network of the brain" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0005048 ! abnormal thrombosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-23T10:04:58Z" xsd:dateTime

[Term]
id: MP:0031169
name: abnormal joint physiology
def: "any functional anomaly of any moveable articulation point of two or more bones" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001533 ! abnormal skeleton physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-23T16:15:20Z" xsd:dateTime

[Term]
id: MP:0031170
name: abnormal vasculature physiology
def: "any functional anomaly of any blood and/or lymphatic vessel" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal vascular physiology" RELATED []
synonym: "abnormal vessel physiology" EXACT []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-09-29T06:44:01Z" xsd:dateTime

[Term]
id: MP:0031171
name: abnormal circulating zinc level
def: "any anomaly in the blood concentration of zinc" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0020893 ! abnormal zinc level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-26T13:29:04Z" xsd:dateTime

[Term]
id: MP:0031172
name: decreased circulating zinc level
def: "less than the normal concentration of zinc in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced circulating zinc level" EXACT []
is_a: MP:0014550 ! decreased zinc level
is_a: MP:0031171 ! abnormal circulating zinc level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-26T13:34:43Z" xsd:dateTime

[Term]
id: MP:0031173
name: increased circulating zinc level
def: "greater than the normal concentration of zinc in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated circulating zinc level" EXACT []
is_a: MP:0014549 ! increased zinc level
is_a: MP:0031171 ! abnormal circulating zinc level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-26T13:38:51Z" xsd:dateTime

[Term]
id: MP:0031174
name: decreased mammary duct terminal end bud number
def: "reduced number of unique club-shaped epithelial structures formed at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; normally, TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [PMID:16280048, PMID:16916375, PMID:18296651]
synonym: "decreased mammary duct TEB number" EXACT []
synonym: "reduced mammary duct TEB number" EXACT []
synonym: "reduced mammary duct terminal end bud number" EXACT []
is_a: MP:0013782 ! abnormal mammary duct terminal end bud morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-27T08:48:02Z" xsd:dateTime

[Term]
id: MP:0031175
name: increased mammary duct terminal end bud number
def: "greater number of unique club-shaped epithelial structures formed at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; normally, TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed; increase in TEBs is often associated with increased ductal outgrowth and branching morphogenesis" [PMID:16280048, PMID:16916375, PMID:18296651]
synonym: "increased mammary duct TEB number" EXACT []
is_a: MP:0013782 ! abnormal mammary duct terminal end bud morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-27T08:57:20Z" xsd:dateTime

[Term]
id: MP:0031176
name: abnormal Descemet membrane thickness
def: "anomaly in the thickness of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004284 ! abnormal Descemet membrane morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-27T11:45:33Z" xsd:dateTime

[Term]
id: MP:0031177
name: decreased Descemet membrane thickness
def: "reduced thickness of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced Descemet membrane thickness" EXACT []
synonym: "thin Descemet membrane" EXACT []
synonym: "thinned Descemet membrane" EXACT []
synonym: "thinning of Descemet membrane" EXACT []
is_a: MP:0031176 ! abnormal Descemet membrane thickness
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-27T12:07:11Z" xsd:dateTime

[Term]
id: MP:0031178
name: increased Descemet membrane thickness
def: "increased thickness of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [https://orcid.org/0000-0002-6490-7723]
synonym: "thick Descemet membrane" EXACT []
synonym: "thickened Descemet membrane" EXACT []
synonym: "thickening of Descemet membrane" EXACT []
is_a: MP:0031176 ! abnormal Descemet membrane thickness
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-27T12:11:55Z" xsd:dateTime

[Term]
id: MP:0031179
name: abnormal brain blood flow rate
def: "aberrant rate of blood flow in the blood vessels supplying the brain" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000233 ! abnormal blood flow velocity
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T11:50:27Z" xsd:dateTime

[Term]
id: MP:0031180
name: decreased brain blood flow rate
def: "reduced rate of blood flow in the blood vessels supplying the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain blood flow rate" EXACT []
is_a: MP:0031179 ! abnormal brain blood flow rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T11:55:58Z" xsd:dateTime

[Term]
id: MP:0031181
name: increased brain blood flow rate
def: "elevated rate of blood flow in the blood vessels supplying the brain" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated brain blood flow rate" EXACT []
is_a: MP:0031179 ! abnormal brain blood flow rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T11:58:29Z" xsd:dateTime

[Term]
id: MP:0031182
name: abnormal cerebral blood flow rate
def: "aberrant rate of blood flow in the blood vessels supplying the cerebral hemispheres" [https://orcid.org/0000-0001-5356-4174]
is_a: MP:0031179 ! abnormal brain blood flow rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T12:02:30Z" xsd:dateTime

[Term]
id: MP:0031183
name: decreased cerebral blood flow rate
def: "reduced rate of blood flow in the blood vessels supplying the cerebral hemispheres" [https://orcid.org/0000-0001-5356-4174, PMID:25397684]
synonym: "reduced cerebral blood flow rate" EXACT []
is_a: MP:0031180 ! decreased brain blood flow rate
is_a: MP:0031182 ! abnormal cerebral blood flow rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T12:05:59Z" xsd:dateTime

[Term]
id: MP:0031184
name: increased cerebral blood flow rate
def: "elevated rate of blood flow in the blood vessels supplying the cerebral hemispheres" [https://orcid.org/0000-0001-5356-4174]
synonym: "elevated cerebral blood flow rate" EXACT []
is_a: MP:0031181 ! increased brain blood flow rate
is_a: MP:0031182 ! abnormal cerebral blood flow rate
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-28T12:12:50Z" xsd:dateTime

[Term]
id: MP:0031185
name: sudden unexpected death in epilepsy
def: "sudden, unexpected death in an organism displaying seizures resulting from a persistent epileptogenic abnormality of the brain, with or without evidence for a seizure immediately preceding the death, in which there is no evidence of other disease, injury, or drowning that caused the death" [ORCID:orcid.org/0000-0003-1726-4769, PMID:22191982]
comment: SUDEP occurs in both humans and non-humans, including non-human primates (PMID:31592545), dogs (PMID:17708395) and mice (PMID:26272185, PMID:23524966).
synonym: "sudden unexplained death in epilepsy" EXACT []
synonym: "SUDEP" EXACT []
is_a: MP:0002083 ! premature death
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T10:09:24Z" xsd:dateTime

[Term]
id: MP:0031186
name: abnormal retina horizontal cell density
def: "any anomaly of the density of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "abnormal horizontal cell density" EXACT []
synonym: "abnormal retinal horizontal cell density" EXACT []
is_a: MP:0006068 ! abnormal retina horizontal cell morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:15:34Z" xsd:dateTime

[Term]
id: MP:0031187
name: decreased retina horizontal cell density
def: "decrease of the density of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "decreased horizontal cell density" EXACT []
synonym: "decreased retinal horizontal cell density" EXACT []
synonym: "reduced horizontal cell density" EXACT []
synonym: "reduced retina horizontal cell density" EXACT []
synonym: "reduced retinal horizontal cell density" EXACT []
is_a: MP:0031186 ! abnormal retina horizontal cell density
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:27:46Z" xsd:dateTime

[Term]
id: MP:0031188
name: increased retina horizontal cell density
def: "increase of the density of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "increased horizontal cell density" EXACT []
synonym: "increased retinal horizontal cell density" EXACT []
is_a: MP:0031186 ! abnormal retina horizontal cell density
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:43:29Z" xsd:dateTime

[Term]
id: MP:0031189
name: abnormal retina rod bipolar cell density
def: "any anomaly of the density of the bipolar cells that function in low light and transmit signals only through amacrine cells" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "abnormal retinal rod bipolar cell density" EXACT []
is_a: MP:0006074 ! abnormal retina rod bipolar cell morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:49:54Z" xsd:dateTime

[Term]
id: MP:0031190
name: decreased retina rod bipolar cell density
def: "decrease of the density of the bipolar cells that function in low light and transmit signals only through amacrine cells" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "decreased retinal rod bipolar cell density" EXACT []
synonym: "reduced retina rod bipolar cell density" EXACT []
synonym: "reduced retinal rod bipolar cell density" EXACT []
is_a: MP:0031189 ! abnormal retina rod bipolar cell density
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:54:21Z" xsd:dateTime

[Term]
id: MP:0031191
name: increased retina rod bipolar cell density
def: "increase of the density of the bipolar cells that function in low light and transmit signals only through amacrine cells" [ORCID:orcid.org/0000-0003-3645-6803, PMID:20127257]
synonym: "increased retinal rod bipolar cell density" EXACT []
is_a: MP:0031189 ! abnormal retina rod bipolar cell density
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T12:57:04Z" xsd:dateTime

[Term]
id: MP:0031192
name: coronary artery spasm
def: "a multi-factorial, transient, and abrupt reduction of luminal diameter of an epicardial coronary artery due to inappropriate constriction of coronary smooth muscle that can generate distal ischemia" [https://www.wikidoc.org/index.php/Coronary_vasospasm]
synonym: "coronary artery vasospasm" EXACT []
synonym: "coronary spasm" EXACT []
synonym: "coronary vasospasm" EXACT []
is_a: MP:0000249 ! abnormal blood vessel physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T15:34:07Z" xsd:dateTime

[Term]
id: MP:0031193
name: pulmonary arterial medial hypertrophy
def: "increase in mass of the tunica media of the arteries in the pulmonary circulation" [HP:0004964, https://orcid.org/0000-0001-5356-4174, PMID:25593290]
synonym: "hypertrophy of the pulmonary artery wall" EXACT []
is_a: MP:0000484 ! abnormal pulmonary artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-29T15:54:34Z" xsd:dateTime

[Term]
id: MP:0031194
name: abnormal testicular artery morphology
def: "any structural anomaly of either of a paired branch of the abdominal aorta that supplies blood to the testis" [https://orcid.org/0000-0002-6490-7723, PMID:11693268, RGD:gthayman]
synonym: "abnormal internal spermatic artery morphology" RELATED []
synonym: "abnormal spermatic artery morphology" RELATED []
is_a: MP:0011655 ! abnormal systemic artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-30T11:42:01Z" xsd:dateTime

[Term]
id: MP:0031195
name: decreased testicular artery wall-to-lumen ratio
def: "a decrease in the ratio of vascular wall thickness to luminal diameter in the testicular artery compared to controls" [https://orcid.org/0000-0002-6490-7723, PMID:11693268, RGD:gthayman]
synonym: "decreased testicular artery wall to lumen ratio" EXACT []
synonym: "decreased wall to lumen ratio of testicular artery" EXACT []
synonym: "decreased wall-to-lumen ratio of testicular artery" EXACT []
synonym: "reduced testicular artery wall to lumen ratio" EXACT []
synonym: "reduced testicular artery wall-to-lumen ratio" EXACT []
is_a: MP:0031194 ! abnormal testicular artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-30T12:22:01Z" xsd:dateTime

[Term]
id: MP:0031196
name: increased testicular artery wall-to-lumen ratio
def: "an increase in the ratio of vascular wall thickness to luminal diameter in the testicular artery compared to controls" [https://orcid.org/0000-0002-6490-7723, PMID:11693268, RGD:gthayman]
synonym: "increased testicular artery wall to lumen ratio" EXACT []
synonym: "increased wall to lumen ratio of testicular artery" EXACT []
synonym: "increased wall-to-lumen ratio of testicular artery" EXACT []
is_a: MP:0031194 ! abnormal testicular artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-30T12:24:54Z" xsd:dateTime

[Term]
id: MP:0031197
name: calcified testicular artery
def: "pathologic deposition of calcium salts in the testicular artery, a branch of the abdominal aorta that supplies blood to the testis" [https://orcid.org/0000-0002-6490-7723, PMID:22912827]
synonym: "calcified internal spermatic artery" RELATED []
synonym: "calcified spermatic artery" RELATED []
synonym: "testicular artery calcification" EXACT []
is_a: MP:0006133 ! calcified artery
is_a: MP:0031194 ! abnormal testicular artery morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-30T13:01:55Z" xsd:dateTime

[Term]
id: MP:0031198
name: retina inner nuclear layer degeneration
def: "a retrogressive impairment or destruction of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells" [https://orcid.org/0000-0002-4154-7358]
synonym: "retinal INL degeneration" EXACT []
synonym: "retinal inner nuclear layer degeneration" EXACT []
is_a: MP:0003733 ! abnormal retina inner nuclear layer morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-10-30T14:07:16Z" xsd:dateTime

[Term]
id: MP:0031199
name: decreased aortic weight
def: "decrease in the average weight of the aorta" [ORCID:orcid.org/0000-0001-5256-8683]
synonym: "decreased aorta weight" EXACT []
synonym: "reduced aorta weight" EXACT []
synonym: "reduced aortic weight" EXACT []
is_a: MP:0002845 ! abnormal aortic weight
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T07:15:41Z" xsd:dateTime

[Term]
id: MP:0031200
name: increased aortic weight
def: "increase in the average weight of the aorta" [ORCID:orcid.org/0000-0001-5256-8683]
synonym: "increased aorta weight" EXACT []
is_a: MP:0002845 ! abnormal aortic weight
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T07:23:59Z" xsd:dateTime

[Term]
id: MP:0031201
name: hemiparesis
def: "mild loss of strength in the limb(s) and sometimes face on one side of the body" [HP:0001269, https://www.healthline.com/health/hemiparesis-vs-hemiplegia]
synonym: "unilateral paresis" EXACT []
is_a: MP:0000754 ! paresis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T16:47:46Z" xsd:dateTime

[Term]
id: MP:0031202
name: hemiplegia
def: "severe or complete loss of muscle function (paralysis) in the limb(s) and in some cases the face on one side of the body" [HP:0002301, https://www.healthline.com/health/hemiparesis-vs-hemiplegia]
synonym: "paralysis on one side of body" EXACT []
is_a: MP:0000753 ! paralysis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T17:03:20Z" xsd:dateTime

[Term]
id: MP:0031203
name: forelimb paresis
def: "mild loss of strength in one or both of the forelimbs" [https://orcid.org/0000-0002-6490-7723]
synonym: "fore limb paresis" EXACT []
synonym: "fore limb weakness" EXACT []
synonym: "forelimb weakness" EXACT []
is_a: MP:0000754 ! paresis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T17:19:38Z" xsd:dateTime

[Term]
id: MP:0031204
name: hindlimb paresis
def: "mild loss of strength in one or both of the hindlimbs" [https://orcid.org/0000-0002-6490-7723]
synonym: "hind limb paresis" EXACT []
synonym: "hind limb weakness" EXACT []
synonym: "hindlimb weakness" EXACT []
synonym: "lameness" RELATED []
synonym: "leg weakness" EXACT []
is_a: MP:0000754 ! paresis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-02T17:34:25Z" xsd:dateTime

[Term]
id: MP:0031205
name: decreased circulating phytosterol level
def: "decrease in the amount of phytosterols in the blood; commonly ingested phytosterols include beta-sitosterol, campesterol, and stigmasterol" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased circulating phytosterol concentration" EXACT []
synonym: "decreased circulating plant sterol concentration" EXACT []
synonym: "decreased circulating plant sterol level" EXACT []
synonym: "reduced circulating phytosterol level" EXACT []
synonym: "reduced circulating plant sterol level" EXACT []
is_a: MP:0010075 ! abnormal circulating phytosterol level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-03T16:26:28Z" xsd:dateTime

[Term]
id: MP:0031206
name: hypolipidemia
def: "abnormally low concentration of lipids in the circulating blood" [PMID:30991053]
synonym: "hypolipaemia" EXACT []
synonym: "hypolipemia" EXACT []
synonym: "hypolipidaemia" EXACT []
is_a: MP:0003949 ! abnormal circulating lipid level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-03T16:34:58Z" xsd:dateTime

[Term]
id: MP:0031207
name: decreased lymphocyte chemotaxis
def: "reduction in the directed movement of a lymphocyte in response to an external stimulus" [https://orcid.org/0000-0002-4154-7358]
synonym: "reduced lymphocyte chemotaxis" EXACT []
is_a: MP:0011825 ! decreased cell chemotaxis
is_a: MP:0011826 ! abnormal lymphocyte chemotaxis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-04T07:53:53Z" xsd:dateTime

[Term]
id: MP:0031208
name: increased lymphocyte chemotaxis
def: "increase in the directed movement of a lymphocyte in response to an external stimulus" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011824 ! increased cell chemotaxis
is_a: MP:0011826 ! abnormal lymphocyte chemotaxis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-04T08:08:15Z" xsd:dateTime

[Term]
id: MP:0031209
name: enlarged cauda epididymis
def: "increase in the average size of the tail of the epididymis" [https://orcid.org/0000-0002-4154-7358, PMID:31318116]
synonym: "increased cauda epididymis size" EXACT []
synonym: "increased caudal epididymis size" EXACT []
is_a: MP:0002662 ! abnormal cauda epididymis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-04T09:15:24Z" xsd:dateTime

[Term]
id: MP:0031210
name: small cauda epididymis
def: "decrease in the average size of the tail of the epididymis" [https://orcid.org/0000-0002-4154-7358]
synonym: "decreased cauda epididymis size" EXACT []
synonym: "decreased caudal epididymis size" EXACT []
synonym: "reduced cauda epididymis size" EXACT []
synonym: "reduced caudal epididymis size" EXACT []
is_a: MP:0002662 ! abnormal cauda epididymis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-04T09:23:05Z" xsd:dateTime

[Term]
id: MP:0031211
name: small corpus epididymis
def: "decrease in the average size of the body of the epididymis" [https://orcid.org/0000-0002-4154-7358]
synonym: "decreased corpus epididymis size" EXACT []
synonym: "reduced corpus epididymis size" EXACT []
is_a: MP:0002661 ! abnormal corpus epididymis morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-04T09:47:42Z" xsd:dateTime

[Term]
id: MP:0031212
name: decreased eye anterior chamber depth
def: "reduced distance between the iris and the cornea at the center plane (maximum distance) of the eye anterior chamber compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced eye anterior chamber depth" EXACT []
synonym: "shallow eye anterior chamber" EXACT []
is_a: MP:0011960 ! abnormal eye anterior chamber depth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-10T08:00:13Z" xsd:dateTime

[Term]
id: MP:0031213
name: increased eye anterior chamber depth
def: "increased distance between the iris and the cornea at the center plane (maximum distance) of the eye anterior chamber compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "deep eye anterior chamber" EXACT []
is_a: MP:0011960 ! abnormal eye anterior chamber depth
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-10T08:05:14Z" xsd:dateTime

[Term]
id: MP:0031214
name: hypercoagulability
def: "a state or condition marked by an increased tendency to form blood clots within a blood vessel(s)" [HP:0100724, https://www.merriam-webster.com/dictionary/hypercoagulability]
synonym: "excessive blood clotting" EXACT []
synonym: "excessive blood coagulability" EXACT []
synonym: "hypercoagulability state" EXACT []
synonym: "prothrombotic state" EXACT []
synonym: "thrombophilia" EXACT []
is_a: MP:0002551 ! abnormal blood coagulation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-11-10T09:06:39Z" xsd:dateTime

[Term]
id: MP:0031215
name: abnormal response to myocardial ischemic injury
def: "altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the myocardium" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal response to myocardial ischaemic injury" EXACT []
synonym: "altered response to myocardial ischaemic injury" EXACT []
synonym: "altered response to myocardial ischemic injury" EXACT []
is_a: MP:0000343 ! abnormal response to cardiac infarction
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-09T14:22:55Z" xsd:dateTime

[Term]
id: MP:0031216
name: decreased susceptibility to myocardial ischemic injury
def: "less severe response, such as decreased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of the myocardium compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to myocardial ischaemic injury" EXACT []
synonym: "increased resistance to myocardial ischaemic injury" EXACT []
synonym: "increased resistance to myocardial ischemic injury" EXACT []
synonym: "reduced susceptibility to myocardial ischaemic injury" EXACT []
synonym: "reduced susceptibility to myocardial ischemic injury" EXACT []
is_a: MP:0005166 ! decreased susceptibility to injury
is_a: MP:0031215 ! abnormal response to myocardial ischemic injury
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-09T14:28:01Z" xsd:dateTime

[Term]
id: MP:0031217
name: increased susceptibility to myocardial ischemic injury
def: "more severe response, such as increased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of the myocardium compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to myocardial ischaemic injury" EXACT []
synonym: "decreased resistance to myocardial ischemic injury" EXACT []
synonym: "increased susceptibility to myocardial ischaemic injury" EXACT []
synonym: "reduced resistance to myocardial ischaemic injury" EXACT []
synonym: "reduced resistance to myocardial ischemic injury" EXACT []
is_a: MP:0005165 ! increased susceptibility to injury
is_a: MP:0031215 ! abnormal response to myocardial ischemic injury
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-09T14:31:59Z" xsd:dateTime

[Term]
id: MP:0031218
name: abnormal circulating CXCL10 level
def: "deviation from the normal blood levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; it is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites" [https://www.prospecbio.com/ip-10, https://www.uniprot.org/uniprot/P02778]
synonym: "abnormal circulating C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "abnormal circulating gamma-IP10 level" EXACT []
synonym: "abnormal circulating IFN gamma-inducible protein 10 level" EXACT []
synonym: "abnormal circulating interferon gamma-induced protein 10 level" EXACT []
synonym: "abnormal circulating IP-10 level" EXACT []
synonym: "abnormal circulating IP10 level" EXACT []
synonym: "abnormal circulating small-inducible cytokine B10 level" EXACT []
is_a: MP:0010209 ! abnormal circulating chemokine level
is_a: MP:0031224 ! abnormal CXCL10 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T09:42:39Z" xsd:dateTime

[Term]
id: MP:0031219
name: decreased circulating CXCL10 level
def: "reduction in the blood levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; this chemokine is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites" [https://www.prospecbio.com/ip-10, https://www.uniprot.org/uniprot/P02778]
synonym: "decreased circulating C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "decreased circulating gamma-IP10 level" EXACT []
synonym: "decreased circulating IFN gamma-inducible protein 10 level" EXACT []
synonym: "decreased circulating interferon gamma-induced protein 10 level" EXACT []
synonym: "decreased circulating IP-10 level" EXACT []
synonym: "decreased circulating IP10 level" EXACT []
synonym: "decreased circulating small-inducible cytokine B10 level" EXACT []
synonym: "reduced circulating CXCL10 level" EXACT []
is_a: MP:0014496 ! decreased circulating chemokine level
is_a: MP:0031218 ! abnormal circulating CXCL10 level
is_a: MP:0031225 ! decreased CXCL10 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T10:49:53Z" xsd:dateTime

[Term]
id: MP:0031220
name: increased circulating CXCL10 level
def: "elevation in the blood levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; this chemokine is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites" [https://www.prospecbio.com/ip-10, https://www.uniprot.org/uniprot/P02778]
synonym: "elevated circulating CXCL10 level" EXACT []
synonym: "increased circulating C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "increased circulating gamma-IP10 level" EXACT []
synonym: "increased circulating IFN gamma-inducible protein 10 level" EXACT []
synonym: "increased circulating interferon gamma-induced protein 10 level" EXACT []
synonym: "increased circulating IP-10 level" EXACT []
synonym: "increased circulating IP10 level" EXACT []
synonym: "increased circulating small-inducible cytokine B10 level" EXACT []
is_a: MP:0014495 ! increased circulating chemokine level
is_a: MP:0031218 ! abnormal circulating CXCL10 level
is_a: MP:0031226 ! increased CXCL10 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T11:29:23Z" xsd:dateTime

[Term]
id: MP:0031221
name: abnormal CXCL10 secretion
def: "anomaly in the production or cellular release of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3" [https://www.prospecbio.com/ip-10, https://www.uniprot.org/uniprot/P02778]
synonym: "abnormal C-X-C motif chemokine ligand 10 secretion" EXACT []
synonym: "abnormal gamma-IP10 secretion" EXACT []
synonym: "abnormal IFN gamma-inducible protein 10 secretion" EXACT []
synonym: "abnormal interferon gamma-induced protein 10 secretion" EXACT []
synonym: "abnormal IP-10 secretion" EXACT []
synonym: "abnormal IP10 secretion" EXACT []
synonym: "abnormal small-inducible cytokine B10 secretion" EXACT []
is_a: MP:0008722 ! abnormal chemokine secretion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T11:59:05Z" xsd:dateTime

[Term]
id: MP:0031222
name: decreased CXCL10 secretion
def: "reduction in the production or cellular release of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased C-X-C motif chemokine ligand 10 secretion" EXACT []
synonym: "decreased gamma-IP10 secretion" EXACT []
synonym: "decreased IFN gamma-inducible protein 10 secretion" EXACT []
synonym: "decreased interferon gamma-induced protein 10 secretion" EXACT []
synonym: "decreased IP-10 secretion" EXACT []
synonym: "decreased IP10 secretion" EXACT []
synonym: "decreased small-inducible cytokine B10 secretion" EXACT []
synonym: "reduced CXCL10 secretion" EXACT []
is_a: MP:0031221 ! abnormal CXCL10 secretion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T12:10:18Z" xsd:dateTime

[Term]
id: MP:0031223
name: increased CXCL10 secretion
def: "increase in the production or cellular release of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated CXCL10 secretion" EXACT []
synonym: "increased C-X-C motif chemokine ligand 10 secretion" EXACT []
synonym: "increased gamma-IP10 secretion" EXACT []
synonym: "increased IFN gamma-inducible protein 10 secretion" EXACT []
synonym: "increased interferon gamma-induced protein 10 secretion" EXACT []
synonym: "increased IP-10 secretion" EXACT []
synonym: "increased IP10 secretion" EXACT []
synonym: "increased small-inducible cytokine B10 secretion" EXACT []
is_a: MP:0031221 ! abnormal CXCL10 secretion
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T12:22:27Z" xsd:dateTime

[Term]
id: MP:0031224
name: abnormal CXCL10 level
def: "deviation from the normal levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; it is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites" [https://www.prospecbio.com/ip-10, https://www.uniprot.org/uniprot/P02778]
synonym: "abnormal C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "abnormal gamma-IP10 level" EXACT []
synonym: "abnormal IFN gamma-inducible protein 10 level" EXACT []
synonym: "abnormal interferon gamma-induced protein 10 level" EXACT []
synonym: "abnormal IP-10 level" EXACT []
synonym: "abnormal IP10 level" EXACT []
synonym: "abnormal small-inducible cytokine B10 level" EXACT []
is_a: MP:0008721 ! abnormal chemokine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T12:32:14Z" xsd:dateTime

[Term]
id: MP:0031225
name: decreased CXCL10 level
def: "reduction in the amount of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "decreased gamma-IP10 level" EXACT []
synonym: "decreased IFN gamma-inducible protein 10 level" EXACT []
synonym: "decreased interferon gamma-induced protein 10 level" EXACT []
synonym: "decreased IP-10 level" EXACT []
synonym: "decreased IP10 level" EXACT []
synonym: "decreased small-inducible cytokine B10 level" EXACT []
synonym: "reduced CXCL10 level" EXACT []
is_a: MP:0014432 ! decreased chemokine level
is_a: MP:0031224 ! abnormal CXCL10 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T12:40:36Z" xsd:dateTime

[Term]
id: MP:0031226
name: increased CXCL10 level
def: "increase in the amount of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated CXCL10 level" EXACT []
synonym: "increased C-X-C motif chemokine ligand 10 level" EXACT []
synonym: "increased gamma-IP10 level" EXACT []
synonym: "increased IFN gamma-inducible protein 10 level" EXACT []
synonym: "increased interferon gamma-induced protein 10 level" EXACT []
synonym: "increased IP-10 level" EXACT []
synonym: "increased IP10 level" EXACT []
synonym: "increased small-inducible cytokine B10 level" EXACT []
is_a: MP:0014431 ! increased chemokine level
is_a: MP:0031224 ! abnormal CXCL10 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T12:53:08Z" xsd:dateTime

[Term]
id: MP:0031227
name: abnormal angiotensin II level
def: "any anomaly in the concentration of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://www.uniprot.org/uniprot/P01019]
is_a: MP:0003953 ! abnormal hormone level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T13:37:32Z" xsd:dateTime

[Term]
id: MP:0031228
name: decreased angiotensin II level
def: "reduced concentration of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://orcid.org/0000-0002-6490-7723, https://www.uniprot.org/uniprot/P01019]
synonym: "reduced angiotensin II level" EXACT []
is_a: MP:0014455 ! decreased hormone level
is_a: MP:0031227 ! abnormal angiotensin II level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T13:45:02Z" xsd:dateTime

[Term]
id: MP:0031229
name: increased angiotensin II level
def: "increased concentration of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://orcid.org/0000-0002-6490-7723, https://www.uniprot.org/uniprot/P01019]
synonym: "elevated angiotensin II level" EXACT []
is_a: MP:0014454 ! increased hormone level
is_a: MP:0031227 ! abnormal angiotensin II level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T13:54:19Z" xsd:dateTime

[Term]
id: MP:0031230
name: abnormal circulating angiotensin II level
def: "aberrant concentration in the blood of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://orcid.org/0000-0002-6490-7723, https://www.uniprot.org/uniprot/P01019]
synonym: "abnormal plasma angiotensin II level" NARROW []
synonym: "abnormal serum angiotensin II level" NARROW []
is_a: MP:0005418 ! abnormal circulating hormone level
is_a: MP:0031227 ! abnormal angiotensin II level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T13:58:23Z" xsd:dateTime

[Term]
id: MP:0031231
name: decreased circulating angiotensin II level
def: "reduced concentration in the blood of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://orcid.org/0000-0002-6490-7723, https://www.uniprot.org/uniprot/P01019]
synonym: "decreased plasma angiotensin II level" NARROW []
synonym: "decreased serum angiotensin II level" NARROW []
synonym: "reduced circulating angiotensin II level" EXACT []
synonym: "reduced plasma angiotensin II level" NARROW []
synonym: "reduced serum angiotensin II level" NARROW []
is_a: MP:0014457 ! decreased circulating hormone level
is_a: MP:0031228 ! decreased angiotensin II level
is_a: MP:0031230 ! abnormal circulating angiotensin II level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T14:07:10Z" xsd:dateTime

[Term]
id: MP:0031232
name: increased circulating angiotensin II level
def: "increased concentration in the blood of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone" [https://medical-dictionary.thefreedictionary.com/angiotensin+II, https://orcid.org/0000-0002-6490-7723, https://www.uniprot.org/uniprot/P01019]
synonym: "elevated circulating angiotensin II level" EXACT []
synonym: "increased plasma angiotensin II level" NARROW []
synonym: "increased serum angiotensin II level" NARROW []
is_a: MP:0014456 ! increased circulating hormone level
is_a: MP:0031229 ! increased angiotensin II level
is_a: MP:0031230 ! abnormal circulating angiotensin II level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-22T14:16:01Z" xsd:dateTime

[Term]
id: MP:0031233
name: decreased circulating serum amyloid protein level
def: "reduced levels in the blood of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased SAA protein level" EXACT []
synonym: "decreased Serum Amyloid A Protein level" EXACT []
synonym: "reduced circulating serum amyloid protein level" EXACT []
synonym: "reduced SAA protein level" EXACT []
synonym: "reduced Serum Amyloid A Protein level" EXACT []
is_a: MP:0010214 ! abnormal circulating serum amyloid protein level
is_a: MP:0014500 ! decreased acute phase protein level
is_a: MP:0014502 ! decreased circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-23T10:41:30Z" xsd:dateTime

[Term]
id: MP:0031234
name: increased circulating serum amyloid protein level
def: "elevated levels in the blood of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated circulating serum amyloid protein level" EXACT []
synonym: "elevated SAA protein level" EXACT []
synonym: "elevated Serum Amyloid A Protein level" EXACT []
synonym: "increased SAA protein level" EXACT []
synonym: "increased Serum Amyloid A Protein level" EXACT []
is_a: MP:0010214 ! abnormal circulating serum amyloid protein level
is_a: MP:0014499 ! increased acute phase protein level
is_a: MP:0014501 ! increased circulating protein level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2020-12-23T10:53:02Z" xsd:dateTime

[Term]
id: MP:0031235
name: decreased cecum weight
def: "reduction in the weight of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased caecum weight" EXACT []
synonym: "reduced caecum weight" EXACT []
synonym: "reduced cecum weight" EXACT []
is_a: MP:0021000 ! abnormal cecum weight
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-08T08:22:27Z" xsd:dateTime

[Term]
id: MP:0031236
name: increased cecum weight
def: "increase in the weight of the large sac at the ileum and large intestine junction" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased caecum weight" EXACT []
is_a: MP:0021000 ! abnormal cecum weight
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-08T08:28:07Z" xsd:dateTime

[Term]
id: MP:0031237
name: diffuse alveolar damage
def: "a common histological injury pattern of the lung, whereby the early stages are characterized by epithelial cell necrosis and sloughing, fibrous exudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli and resulting in impaired gas exchange; in later stages, alveolar type II cells and myofibroblasts proliferate within the interstitium and airspaces; the corresponding clinical entity is ARDS (acute respiratory distress syndrome)" [HP:0033006, PMID:28570160]
is_a: MP:0010899 ! abnormal pulmonary alveolar system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-08T10:36:03Z" xsd:dateTime

[Term]
id: MP:0031238
name: reactive type II pneumocyte hyperplasia
def: "alteration to type II pneumocytes following lung injury that results in increased numbers of these cells occurring in clusters and having morphological alterations including: cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin" [PMID:11079017]
comment: reactive type II pneumocyte hyperplasia develops as a response to alveolar injury in various pulmonary disorders, esp. in the setting of inflammation and interstitial fibrosis and during the healing phase of diffuse alveolar damage
synonym: "reactive alveolar type II cell hyperplasia" EXACT []
is_a: MP:0010810 ! increased type II pneumocyte number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-08T12:21:37Z" xsd:dateTime

[Term]
id: MP:0031239
name: increased atretic ovarian follicle number
def: "increase in the number of degenerated immature ovarian follicles" [http://medcell.med.yale.edu/histology/female_reproductive_system_lab/atretic_follicle.php, https://www.sciencedirect.com/topics/medicine-and-dentistry/ovary-follicle-atresia]
synonym: "elevated atretic ovarian follicle number" EXACT []
is_a: MP:0008871 ! abnormal ovarian follicle number
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T08:00:01Z" xsd:dateTime

[Term]
id: MP:0031240
name: abnormal CSF3 level
def: "deviation from the normal levels of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "abnormal colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "abnormal colony stimulating factor 3 level" EXACT []
synonym: "abnormal colony-stimulating factor 3 level" EXACT []
synonym: "abnormal G-CSF level" EXACT []
synonym: "abnormal GCSF level" EXACT []
synonym: "abnormal granulocyte colony stimulating factor level" EXACT []
synonym: "abnormal granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0008713 ! abnormal cytokine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T10:18:21Z" xsd:dateTime

[Term]
id: MP:0031241
name: decreased CSF3 level
def: "reduction in the amount of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "decreased colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "decreased colony stimulating factor 3 level" EXACT []
synonym: "decreased colony-stimulating factor 3 level" EXACT []
synonym: "decreased G-CSF level" EXACT []
synonym: "decreased GCSF level" EXACT []
synonym: "decreased granulocyte colony stimulating factor level" EXACT []
synonym: "decreased granulocyte colony-stimulating factor level" EXACT []
synonym: "reduced colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "reduced colony stimulating factor 3 level" EXACT []
synonym: "reduced colony-stimulating factor 3 level" EXACT []
synonym: "reduced G-CSF level" EXACT []
synonym: "reduced GCSF level" EXACT []
synonym: "reduced granulocyte colony stimulating factor level" EXACT []
synonym: "reduced granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0014434 ! decreased cytokine level
is_a: MP:0031240 ! abnormal CSF3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T10:30:40Z" xsd:dateTime

[Term]
id: MP:0031242
name: increased CSF3 level
def: "increase in the amount of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "increased colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "increased colony stimulating factor 3 level" EXACT []
synonym: "increased colony-stimulating factor 3 level" EXACT []
synonym: "increased G-CSF level" EXACT []
synonym: "increased GCSF level" EXACT []
synonym: "increased granulocyte colony stimulating factor level" EXACT []
synonym: "increased granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0014433 ! increased cytokine level
is_a: MP:0031240 ! abnormal CSF3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T10:42:19Z" xsd:dateTime

[Term]
id: MP:0031243
name: abnormal circulating CSF3 level
def: "deviation from the normal blood levels of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "abnormal circulating colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "abnormal circulating colony stimulating factor 3 level" EXACT []
synonym: "abnormal circulating colony-stimulating factor 3 level" EXACT []
synonym: "abnormal circulating G-CSF level" EXACT []
synonym: "abnormal circulating GCSF level" EXACT []
synonym: "abnormal circulating granulocyte colony stimulating factor level" EXACT []
synonym: "abnormal circulating granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0010210 ! abnormal circulating cytokine level
is_a: MP:0031240 ! abnormal CSF3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T10:48:41Z" xsd:dateTime

[Term]
id: MP:0031244
name: decreased circulating CSF3 level
def: "reduction in the blood levels of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "decreased circulating colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "decreased circulating colony stimulating factor 3 level" EXACT []
synonym: "decreased circulating colony-stimulating factor 3 level" EXACT []
synonym: "decreased circulating G-CSF level" EXACT []
synonym: "decreased circulating GCSF level" EXACT []
synonym: "decreased circulating granulocyte colony stimulating factor level" EXACT []
synonym: "decreased circulating granulocyte colony-stimulating factor level" EXACT []
synonym: "reduced circulating colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "reduced circulating colony stimulating factor 3 level" EXACT []
synonym: "reduced circulating colony-stimulating factor 3 level" EXACT []
synonym: "reduced circulating G-CSF level" EXACT []
synonym: "reduced circulating GCSF level" EXACT []
synonym: "reduced circulating granulocyte colony stimulating factor level" EXACT []
synonym: "reduced circulating granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0014494 ! decreased circulating cytokine level
is_a: MP:0031241 ! decreased CSF3 level
is_a: MP:0031243 ! abnormal circulating CSF3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T10:56:54Z" xsd:dateTime

[Term]
id: MP:0031245
name: increased circulating CSF3 level
def: "increase in the blood levels of CSF3, a cytokine glycoprotein produced by endothelium, macrophages and other immune cells that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream; it also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways" [https://en.wikipedia.org/wiki/Granulocyte_colony-stimulating_factor, ISBN:978-0-12-802225-2]
synonym: "increased circulating colony stimulating factor 3 (granulocyte) level" EXACT []
synonym: "increased circulating colony stimulating factor 3 level" EXACT []
synonym: "increased circulating colony-stimulating factor 3 level" EXACT []
synonym: "increased circulating G-CSF level" EXACT []
synonym: "increased circulating GCSF level" EXACT []
synonym: "increased circulating granulocyte colony stimulating factor level" EXACT []
synonym: "increased circulating granulocyte colony-stimulating factor level" EXACT []
is_a: MP:0014493 ! increased circulating cytokine level
is_a: MP:0031242 ! increased CSF3 level
is_a: MP:0031243 ! abnormal circulating CSF3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T11:07:13Z" xsd:dateTime

[Term]
id: MP:0031246
name: abnormal CCL3 level
def: "deviation from the normal levels of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "abnormal C-C motif chemokine 3 level" EXACT []
synonym: "abnormal macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "abnormal MIP-1 alpha level" EXACT []
synonym: "abnormal MIP-1alpha level" EXACT []
synonym: "abnormal MIP1-alpha level" EXACT []
synonym: "abnormal MIP1A level" EXACT []
is_a: MP:0008721 ! abnormal chemokine level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T11:54:53Z" xsd:dateTime

[Term]
id: MP:0031247
name: decreased CCL3 level
def: "reduction in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "decreased C-C motif chemokine 3 level" EXACT []
synonym: "decreased macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "decreased MIP-1 alpha level" EXACT []
synonym: "decreased MIP-1alpha level" EXACT []
synonym: "decreased MIP1-alpha level" EXACT []
synonym: "decreased MIP1A level" EXACT []
synonym: "reduced C-C motif chemokine 3 level" EXACT []
synonym: "reduced macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "reduced MIP-1 alpha level" EXACT []
synonym: "reduced MIP-1alpha level" EXACT []
synonym: "reduced MIP1-alpha level" EXACT []
synonym: "reduced MIP1A level" EXACT []
is_a: MP:0014432 ! decreased chemokine level
is_a: MP:0031246 ! abnormal CCL3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T12:03:23Z" xsd:dateTime

[Term]
id: MP:0031248
name: increased CCL3 level
def: "increase in the amount of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "increased C-C motif chemokine 3 level" EXACT []
synonym: "increased macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "increased MIP-1 alpha level" EXACT []
synonym: "increased MIP-1alpha level" EXACT []
synonym: "increased MIP1-alpha level" EXACT []
synonym: "increased MIP1A level" EXACT []
is_a: MP:0014431 ! increased chemokine level
is_a: MP:0031246 ! abnormal CCL3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T12:10:19Z" xsd:dateTime

[Term]
id: MP:0031249
name: abnormal circulating CCL3 level
def: "deviation from the normal blood levels of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "abnormal circulating C-C motif chemokine 3 level" EXACT []
synonym: "abnormal circulating macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "abnormal circulating MIP-1 alpha level" EXACT []
synonym: "abnormal circulating MIP-1alpha level" EXACT []
synonym: "abnormal circulating MIP1-alpha level" EXACT []
synonym: "abnormal circulating MIP1A level" EXACT []
is_a: MP:0010209 ! abnormal circulating chemokine level
is_a: MP:0031246 ! abnormal CCL3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T12:14:52Z" xsd:dateTime

[Term]
id: MP:0031250
name: decreased circulating CCL3 level
def: "reduction in the blood levels of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "decreased circulating C-C motif chemokine 3 level" EXACT []
synonym: "decreased circulating macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "decreased circulating MIP-1 alpha level" EXACT []
synonym: "decreased circulating MIP-1alpha level" EXACT []
synonym: "decreased circulating MIP1-alpha level" EXACT []
synonym: "decreased circulating MIP1A level" EXACT []
synonym: "reduced circulating C-C motif chemokine 3 level" EXACT []
synonym: "reduced circulating macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "reduced circulating MIP-1 alpha level" EXACT []
synonym: "reduced circulating MIP-1alpha level" EXACT []
synonym: "reduced circulating MIP1-alpha level" EXACT []
synonym: "reduced circulating MIP1A level" EXACT []
is_a: MP:0014496 ! decreased circulating chemokine level
is_a: MP:0031247 ! decreased CCL3 level
is_a: MP:0031249 ! abnormal circulating CCL3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T12:23:34Z" xsd:dateTime

[Term]
id: MP:0031251
name: increased circulating CCL3 level
def: "increase in the blood levels of CCL3 protein, a chemokine that is secreted by a variety of hematopoietic and non-hematopoietic cells upon stimulation and plays a key role in recruiting inflammatory cells (macrophages, lymphocytes, eosinophils and basophils) to sites of injury or inflammation via the CCR1 or CCR5 receptor; it helps promote wound healing by recruiting macrophages to sites of tissue injury; acts as a potent osteoclast activator and induces bone resorption; exerts HIV-suppressive activity; and inhibits hematopoietic stem cell proliferation" [https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-7696-8_27]
synonym: "increased circulating C-C motif chemokine 3 level" EXACT []
synonym: "increased circulating macrophage inflammatory protein 1-alpha level" EXACT []
synonym: "increased circulating MIP-1 alpha level" EXACT []
synonym: "increased circulating MIP-1alpha level" EXACT []
synonym: "increased circulating MIP1-alpha level" EXACT []
synonym: "increased circulating MIP1A level" EXACT []
is_a: MP:0014495 ! increased circulating chemokine level
is_a: MP:0031248 ! increased CCL3 level
is_a: MP:0031249 ! abnormal circulating CCL3 level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T12:31:21Z" xsd:dateTime

[Term]
id: MP:0031252
name: abnormal physiological response to hypoxia
def: "any anomaly in the expected physiological response of a cell or an organism to reduced tissue levels of oxygen resulting from either internal or external changes in oxygen levels" [https://orcid.org/0000-0002-6490-7723]
comment: This term is not to be used for behavioral responses to hypoxia.
synonym: "abnormal physiological response to hypoxic stress" EXACT []
is_a: MP:0005376 ! homeostasis/metabolism phenotype
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-03-29T13:08:50Z" xsd:dateTime

[Term]
id: MP:0031253
name: lordokyphosis
def: "a combination of kyphosis and lordosis" [https://en.wiktionary.org/wiki/lordokyphosis]
synonym: "kypholordosis" EXACT []
is_a: MP:0000160 ! kyphosis
is_a: MP:0000162 ! lordosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T10:49:35Z" xsd:dateTime

[Term]
id: MP:0031254
name: decreased vitamin C level
def: "any concentration below the normal range of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
synonym: "decreased ascorbate level" EXACT []
synonym: "decreased ascorbic acid level" EXACT []
synonym: "decreased L-ascorbic acid level" EXACT []
synonym: "reduced ascorbate level" EXACT []
synonym: "reduced ascorbic acid level" EXACT []
synonym: "reduced L-ascorbic acid level" EXACT []
synonym: "reduced vitamin C level" EXACT []
is_a: MP:0011229 ! abnormal vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T17:50:46Z" xsd:dateTime

[Term]
id: MP:0031255
name: increased vitamin C level
def: "any concentration above the normal range of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
synonym: "increased ascorbate level" EXACT []
synonym: "increased ascorbic acid level" EXACT []
synonym: "increased L-ascorbic acid level" EXACT []
is_a: MP:0011229 ! abnormal vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:03:25Z" xsd:dateTime

[Term]
id: MP:0031256
name: abnormal circulating vitamin C level
def: "any anomaly in the concentration of L-ascorbic acid (vitamin C) in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal circulating ascorbate level" EXACT []
synonym: "abnormal circulating ascorbic acid level" EXACT []
synonym: "abnormal circulating L-ascorbic acid level" EXACT []
synonym: "abnormal plasma ascorbate level" NARROW []
synonym: "abnormal plasma ascorbic acid level" NARROW []
synonym: "abnormal plasma L-ascorbic acid level" NARROW []
synonym: "abnormal plasma vitamin C level" NARROW []
synonym: "abnormal serum ascorbate level" NARROW []
synonym: "abnormal serum ascorbic acid level" NARROW []
synonym: "abnormal serum L-ascorbic acid level" NARROW []
synonym: "abnormal serum vitamin C level" NARROW []
is_a: MP:0011229 ! abnormal vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:08:19Z" xsd:dateTime

[Term]
id: MP:0031257
name: decreased circulating vitamin C level
def: "reduced concentration of L-ascorbic acid (vitamin C) in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased circulating ascorbate level" EXACT []
synonym: "decreased circulating ascorbic acid level" EXACT []
synonym: "decreased circulating L-ascorbic acid level" EXACT []
synonym: "decreased plasma ascorbate level" NARROW []
synonym: "decreased plasma ascorbic acid level" NARROW []
synonym: "decreased plasma L-ascorbic acid level" NARROW []
synonym: "decreased plasma vitamin C level" NARROW []
synonym: "decreased serum ascorbate level" NARROW []
synonym: "decreased serum ascorbic acid level" NARROW []
synonym: "decreased serum L-ascorbic acid level" NARROW []
synonym: "decreased serum vitamin C level" NARROW []
synonym: "reduced circulating ascorbate level" EXACT []
synonym: "reduced circulating ascorbic acid level" EXACT []
synonym: "reduced circulating L-ascorbic acid level" EXACT []
synonym: "reduced circulating vitamin C level" EXACT []
is_a: MP:0031254 ! decreased vitamin C level
is_a: MP:0031256 ! abnormal circulating vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:15:43Z" xsd:dateTime

[Term]
id: MP:0031258
name: increased circulating vitamin C level
def: "increased concentration of L-ascorbic acid (vitamin C) in the blood" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased circulating ascorbate level" EXACT []
synonym: "increased circulating ascorbic acid level" EXACT []
synonym: "increased circulating L-ascorbic acid level" EXACT []
synonym: "increased plasma ascorbate level" NARROW []
synonym: "increased plasma ascorbic acid level" NARROW []
synonym: "increased plasma L-ascorbic acid level" NARROW []
synonym: "increased plasma vitamin C level" NARROW []
synonym: "increased serum ascorbate level" NARROW []
synonym: "increased serum ascorbic acid level" NARROW []
synonym: "increased serum L-ascorbic acid level" NARROW []
synonym: "increased serum vitamin C level" NARROW []
is_a: MP:0031255 ! increased vitamin C level
is_a: MP:0031256 ! abnormal circulating vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:22:46Z" xsd:dateTime

[Term]
id: MP:0031259
name: abnormal liver vitamin C level
def: "any anomaly in the concentration of L-ascorbic acid (vitamin C) in the liver" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal hepatic ascorbate level" EXACT []
synonym: "abnormal hepatic ascorbic acid level" EXACT []
synonym: "abnormal hepatic L-ascorbic acid level" EXACT []
synonym: "abnormal hepatic vitamin C level" EXACT []
synonym: "abnormal liver ascorbate level" EXACT []
synonym: "abnormal liver ascorbic acid level" EXACT []
synonym: "abnormal liver L-ascorbic acid level" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
is_a: MP:0011229 ! abnormal vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:29:30Z" xsd:dateTime

[Term]
id: MP:0031260
name: decreased liver vitamin C level
def: "reduced concentration of L-ascorbic acid (vitamin C) in the liver" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased hepatic ascorbate level" EXACT []
synonym: "decreased hepatic ascorbic acid level" EXACT []
synonym: "decreased hepatic L-ascorbic acid level" EXACT []
synonym: "decreased hepatic vitamin C level" EXACT []
synonym: "decreased liver ascorbate level" EXACT []
synonym: "decreased liver ascorbic acid level" EXACT []
synonym: "decreased liver L-ascorbic acid level" EXACT []
synonym: "reduced hepatic ascorbate level" EXACT []
synonym: "reduced hepatic ascorbic acid level" EXACT []
synonym: "reduced hepatic L-ascorbic acid level" EXACT []
synonym: "reduced hepatic vitamin C level" EXACT []
synonym: "reduced liver ascorbate level" EXACT []
synonym: "reduced liver ascorbic acid level" EXACT []
synonym: "reduced liver L-ascorbic acid level" EXACT []
synonym: "reduced liver vitamin C level" EXACT []
is_a: MP:0031254 ! decreased vitamin C level
is_a: MP:0031259 ! abnormal liver vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:35:42Z" xsd:dateTime

[Term]
id: MP:0031261
name: increased liver vitamin C level
def: "increased concentration of L-ascorbic acid (vitamin C) in the liver" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased hepatic ascorbate level" EXACT []
synonym: "increased hepatic ascorbic acid level" EXACT []
synonym: "increased hepatic L-ascorbic acid level" EXACT []
synonym: "increased hepatic vitamin C level" EXACT []
synonym: "increased liver ascorbate level" EXACT []
synonym: "increased liver ascorbic acid level" EXACT []
synonym: "increased liver L-ascorbic acid level" EXACT []
is_a: MP:0031255 ! increased vitamin C level
is_a: MP:0031259 ! abnormal liver vitamin C level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-12T18:41:38Z" xsd:dateTime

[Term]
id: MP:0031262
name: abnormal vitamin K level
def: "any anomaly in the concentration of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals; vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule" [GO:0042373]
is_a: MP:0005401 ! abnormal fat-soluble vitamin level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-26T08:25:04Z" xsd:dateTime

[Term]
id: MP:0031263
name: decreased vitamin K level
def: "reduced concentration of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals" [GO:0042373]
synonym: "low vitamin K level" EXACT []
synonym: "reduced vitamin K level" EXACT []
is_a: MP:0031262 ! abnormal vitamin K level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-26T08:31:52Z" xsd:dateTime

[Term]
id: MP:0031264
name: increased vitamin K level
def: "increased concentration of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals" [GO:0042373]
synonym: "elevated vitamin K level" EXACT []
is_a: MP:0031262 ! abnormal vitamin K level
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-04-26T08:34:48Z" xsd:dateTime

[Term]
id: MP:0031265
name: increased susceptibility to hepatic steatosis
def: "more likely than normal to develop hepatic steatosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to fatty liver development" EXACT []
synonym: "decreased resistance to hepatic steatosis" EXACT []
synonym: "increased susceptibility to fatty liver development" EXACT []
synonym: "reduced resistance to fatty liver development" EXACT []
synonym: "reduced resistance to hepatic steatosis" EXACT []
is_a: MP:0000598 ! abnormal liver morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:25:09Z" xsd:dateTime

[Term]
id: MP:0031266
name: decreased susceptibility to alcohol-induced hepatic steatosis
def: "less likely than normal to develop hepatic steatosis following acute or chronic alcohol administration" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to alcohol-induced fatty liver development" EXACT []
synonym: "decreased susceptibility to ethanol-induced fatty liver development" EXACT []
synonym: "decreased susceptibility to ethanol-induced hepatic steatosis" EXACT []
synonym: "increased resistance to alcohol-induced hepatic steatosis" EXACT []
synonym: "increased resistance to ethanol-induced hepatic steatosis" EXACT []
synonym: "reduced susceptibility to alcohol-induced hepatic steatosis" EXACT []
synonym: "reduced susceptibility to ethanol-induced hepatic steatosis" EXACT []
is_a: MP:0002310 ! decreased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:29:59Z" xsd:dateTime

[Term]
id: MP:0031267
name: increased susceptibility to alcohol-induced hepatic steatosis
def: "more likely than normal to develop hepatic steatosis following acute or chronic alcohol administration" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to alcohol-induced hepatic steatosis" EXACT []
synonym: "decreased resistance to ethanol-induced hepatic steatosis" EXACT []
synonym: "increased susceptibility to alcohol-induced fatty liver development" EXACT []
synonym: "increased susceptibility to ethanol-induced fatty liver development" EXACT []
synonym: "increased susceptibility to ethanol-induced hepatic steatosis" EXACT []
synonym: "reduced resistance to alcohol-induced hepatic steatosis" EXACT []
synonym: "reduced resistance to ethanol-induced hepatic steatosis" EXACT []
is_a: MP:0031265 ! increased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:33:28Z" xsd:dateTime

[Term]
id: MP:0031268
name: decreased susceptibility to diet-induced hepatic steatosis
def: "less likely than normal to develop diet-induced hepatic steatosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to diet-induced fatty liver development" EXACT []
synonym: "increased resistance to diet-induced hepatic steatosis" EXACT []
synonym: "reduced susceptibility to diet-induced hepatic steatosis" EXACT []
is_a: MP:0002310 ! decreased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:37:49Z" xsd:dateTime

[Term]
id: MP:0031269
name: increased susceptibility to diet-induced hepatic steatosis
def: "more likely than normal to develop diet-induced hepatic steatosis" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to diet-induced hepatic steatosis" EXACT []
synonym: "increased susceptibility to diet-induced fatty liver development" EXACT []
synonym: "reduced resistance to diet-induced hepatic steatosis" EXACT []
is_a: MP:0031265 ! increased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:41:15Z" xsd:dateTime

[Term]
id: MP:0031270
name: decreased susceptibility to age-related hepatic steatosis
def: "less likely than normal to develop hepatic steatosis that is progressive with age" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased susceptibility to age-related fatty liver development" EXACT []
synonym: "increased resistance to age-related hepatic steatosis" EXACT []
synonym: "reduced susceptibility to age-related hepatic steatosis" EXACT []
is_a: MP:0002310 ! decreased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:44:40Z" xsd:dateTime

[Term]
id: MP:0031271
name: increased susceptibility to age-related hepatic steatosis
def: "more likely than normal to develop hepatic steatosis that is progressive with age" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to age-related hepatic steatosis" EXACT []
synonym: "increased susceptibility to age-related fatty liver development" EXACT []
synonym: "reduced resistance to age-related hepatic steatosis" EXACT []
is_a: MP:0031265 ! increased susceptibility to hepatic steatosis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T10:47:45Z" xsd:dateTime

[Term]
id: MP:0031272
name: abnormal susceptibility to induced aneurysm formation
def: "any anomaly in the frequency, rate or severity of aneurysm formation following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "altered resistance to induced aneurysm formation" RELATED []
synonym: "altered susceptibility to induced aneurysm formation" EXACT []
is_a: MP:0002127 ! abnormal cardiovascular system morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T15:49:22Z" xsd:dateTime

[Term]
id: MP:0031273
name: decreased susceptibility to induced aneurysm formation
def: "decreased frequency, rate or severity of aneurysm formation following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to induced aneurysm formation" EXACT []
synonym: "reduced susceptibility to induced aneurysm formation" EXACT []
is_a: MP:0031272 ! abnormal susceptibility to induced aneurysm formation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T15:53:43Z" xsd:dateTime

[Term]
id: MP:0031274
name: increased susceptibility to induced aneurysm formation
def: "increased frequency, rate or severity of aneurysm formation following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to induced aneurysm formation" EXACT []
synonym: "reduced resistance to induced aneurysm formation" EXACT []
is_a: MP:0031272 ! abnormal susceptibility to induced aneurysm formation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-05-10T15:58:50Z" xsd:dateTime

[Term]
id: MP:0031275
name: abnormal heme metabolism
def: "any anomaly in the chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring" [GO:0042168]
synonym: "abnormal heme metabolic process" EXACT []
is_a: MP:0005266 ! abnormal metabolism
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-07T10:52:10Z" xsd:dateTime

[Term]
id: MP:0031276
name: abnormal stress erythropoiesis
def: "any anomaly in the process by which erythroid output is increased in response to anemic stress" [PMID:32750404]
synonym: "abnormal stress-induced erythropoiesis" EXACT []
is_a: MP:0000245 ! abnormal erythropoiesis
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-07T11:11:39Z" xsd:dateTime

[Term]
id: MP:0031277
name: pectus carinatum
def: "a congenital deformity of the anterior chest wall characterized by outward protrusion of the sternum and/or adjacent ribs" [https://www.uptodate.com/contents/pectus-carinatum, PMID:23868604, PMID:29325984]
synonym: "keel chest" EXACT []
synonym: "pigeon breast" RELATED []
synonym: "pigeon chest" EXACT []
synonym: "pyramidal chest" RELATED []
synonym: "sternal kyphosis" RELATED []
synonym: "thorax cuneiform" RELATED []
is_a: MP:0004134 ! abnormal chest morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-11T09:57:35Z" xsd:dateTime

[Term]
id: MP:0031278
name: decreased osteosarcoma incidence
def: "less than the expected number of a malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes, occurring in a specific population in a given time period; osteosarcoma is a highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone" [MPATH:397]
synonym: "decreased osteogenic sarcoma incidence" RELATED []
is_a: MP:0012415 ! decreased sarcoma incidence
is_a: MP:0012426 ! decreased skeletal tumor incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T07:29:26Z" xsd:dateTime

[Term]
id: MP:0031279
name: abnormal susceptibility to aneurysm induced morbidity/mortality
def: "differences from the expected moribund state caused by aneurysm rupture following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal sensitivity to aneurysm induced morbidity/mortality" EXACT []
synonym: "altered resistance to aneurysm induced morbidity/mortality" RELATED []
synonym: "altered susceptibility to aneurysm induced morbidity/mortality" EXACT []
is_a: MP:0001657 ! abnormal induced morbidity/mortality
is_a: MP:0031272 ! abnormal susceptibility to induced aneurysm formation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T08:51:19Z" xsd:dateTime

[Term]
id: MP:0031280
name: decreased susceptibility to aneurysm induced morbidity/mortality
def: "reduced likelihood that an organism will display the expected moribund state caused by aneurysm rupture following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased sensitivity to aneurysm induced morbidity/mortality" EXACT []
synonym: "increased resistance to aneurysm induced morbidity/mortality" EXACT []
synonym: "reduced susceptibility to aneurysm induced morbidity/mortality" EXACT []
is_a: MP:0031273 ! decreased susceptibility to induced aneurysm formation
is_a: MP:0031279 ! abnormal susceptibility to aneurysm induced morbidity/mortality
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T08:56:21Z" xsd:dateTime

[Term]
id: MP:0031281
name: increased susceptibility to aneurysm induced morbidity/mortality
def: "increased likelihood that an organism will display the expected moribund state caused by aneurysm rupture following experimental induction of heart or vessel wall weakening by chemical and/or physical means" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to aneurysm induced morbidity/mortality" EXACT []
synonym: "increased sensitivity to aneurysm induced morbidity/mortality" EXACT []
synonym: "reduced resistance to aneurysm induced morbidity/mortality" EXACT []
is_a: MP:0031274 ! increased susceptibility to induced aneurysm formation
is_a: MP:0031279 ! abnormal susceptibility to aneurysm induced morbidity/mortality
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T09:00:11Z" xsd:dateTime

[Term]
id: MP:0031282
name: decreased enchondroma incidence
def: "less than the expected number of benign lobulated neoplasms of hyaline cartilage occurring in bones of endochondral origin, in a specific population in a given time period; enchondromas are usually solitary, intramedullary lesions commonly found in the short tubular bones of the hands and feet, distal femur, and proximal humerus" [https://www.ncbi.nlm.nih.gov/books/NBK536938/]
synonym: "reduced enchondroma incidence" EXACT []
is_a: MP:0012426 ! decreased skeletal tumor incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T15:54:48Z" xsd:dateTime

[Term]
id: MP:0031283
name: increased enchondroma incidence
def: "greater than the expected number of benign lobulated neoplasms of hyaline cartilage occurring in bones of endochondral origin, in a specific population in a given time period; enchondromas are usually solitary, intramedullary lesions commonly found in the short tubular bones of the hands and feet, distal femur, and proximal humerus" [https://www.ncbi.nlm.nih.gov/books/NBK536938/]
synonym: "enchondroma" RELATED []
is_a: MP:0010280 ! increased skeletal tumor incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-06-30T16:04:55Z" xsd:dateTime

[Term]
id: MP:0031284
name: abdominal situs abnormality
def: "an abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs" [HP:0011620]
is_a: MP:0004133 ! heterotaxia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-07-01T08:54:30Z" xsd:dateTime

[Term]
id: MP:0031285
name: external auditory canal stenosis
def: "abnormal narrowing or constriction of the external auditory canal" [https://orcid.org/0000-0002-6490-7723]
synonym: "external acoustic meatus stenosis" EXACT []
synonym: "narrow external auditory canal" EXACT []
synonym: "narrowing of external auditory canal" EXACT []
synonym: "stenosis of external auditory canal" EXACT []
synonym: "stenotic external acoustic meatus" EXACT []
synonym: "stenotic external auditory canal" EXACT []
is_a: MP:0006033 ! abnormal external auditory canal morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-07-26T08:26:22Z" xsd:dateTime

[Term]
id: MP:0031286
name: unilateral cryptorchism
def: "failure of one of the testes to descend into the scrotum" [https://orcid.org/0000-0002-6490-7723]
synonym: "unilateral cryptorchidism" EXACT []
is_a: MP:0002286 ! cryptorchism
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-07-26T10:58:08Z" xsd:dateTime

[Term]
id: MP:0031287
name: bilateral cryptorchism
def: "failure of both testes to descend into the scrotum" [https://orcid.org/0000-0002-6490-7723]
synonym: "bilateral cryptorchidism" EXACT []
is_a: MP:0002286 ! cryptorchism
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-07-26T11:02:30Z" xsd:dateTime

[Term]
id: MP:0031288
name: long eyelid cilia
def: "increased length of any of the hairs that grow at the edge of the upper or lower eyelid" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased eyelash length" EXACT []
synonym: "increased eyelid cilia length" EXACT []
synonym: "increased eyelid cilium length" EXACT []
synonym: "increased lash length" EXACT []
synonym: "long eyelashes" EXACT []
is_a: MP:0013895 ! abnormal eyelid cilium morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-20T06:51:06Z" xsd:dateTime

[Term]
id: MP:0031289
name: unilateral microphthalmia
def: "reduced average size of one eye; generally refers to a congenital defect" [https://orcid.org/0000-0002-6490-7723]
synonym: "unilateral microphthalmos" EXACT []
is_a: MP:0001297 ! microphthalmia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-20T08:58:44Z" xsd:dateTime

[Term]
id: MP:0031290
name: bilateral microphthalmia
def: "reduced average size of both eyes; generally refers to a congenital defect" [https://orcid.org/0000-0002-6490-7723]
synonym: "bilateral microphthalmos" EXACT []
is_a: MP:0001297 ! microphthalmia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-20T09:02:48Z" xsd:dateTime

[Term]
id: MP:0031291
name: pes valgus
def: "an outward deviation of the foot at the talocalcaneal or subtalar joint" [HP:0008081, https://www.biologyonline.com/dictionary/pes-valgus]
synonym: "valgus foot deformity" EXACT []
is_a: MP:0000556 ! abnormal hindlimb morphology
is_a: MP:0000572 ! abnormal autopod morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-20T09:46:05Z" xsd:dateTime

[Term]
id: MP:0031292
name: increased facial hemangioma incidence
def: "greater than the expected number of benign tumors characterized by blood-filled spaces lined by benign endothelial cells in the face, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "facial angioma" RELATED []
synonym: "facial haemangioma" RELATED []
synonym: "facial hemangioma" RELATED []
synonym: "increased facial angiomoma incidence" RELATED []
synonym: "increased facial haemangioma incidence" EXACT []
is_a: MP:0002947 ! increased hemangioma incidence
is_a: MP:0008018 ! increased facial tumor incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T09:16:55Z" xsd:dateTime

[Term]
id: MP:0031293
name: decreased facial hemangioma incidence
def: "less than the expected number of benign tumors characterized by blood-filled spaces lined by benign endothelial cells in the face, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased facial angiomoma incidence" RELATED []
synonym: "decreased facial haemangioma incidence" EXACT []
is_a: MP:0020226 ! decreased hemangioma incidence
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T09:29:16Z" xsd:dateTime

[Term]
id: MP:0031294
name: penile hypospadia
def: "a form of male hypospadia where the opening of the male urethra is located on the inferior aspect of the penis" [HP:0003244]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:27:25Z" xsd:dateTime

[Term]
id: MP:0031295
name: glanular hypospadia
def: "the mildest and most common form of male hypospadias where the opening of the male urethra is located on the head of the penis, but not at the tip" [https://nyulangone.org/conditions/hypospadias-in-children/types]
comment: Also referred to as glandular hypospadia.
synonym: "glandular hypospadia" RELATED []
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:33:19Z" xsd:dateTime

[Term]
id: MP:0031296
name: penoscrotal hypospadia
def: "a severe form of male hypospadia where the opening of the male urethra is located where the shaft of the penis meets the scrotum" [HP:0000808]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:36:54Z" xsd:dateTime

[Term]
id: MP:0031297
name: midshaft hypospadia
def: "a form of male hypospadia where the opening of the male urethra is located in the middle of the inferior shaft of the penis" [HP:0012854, https://nyulangone.org/conditions/hypospadias-in-children/types]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:39:22Z" xsd:dateTime

[Term]
id: MP:0031298
name: coronal hypospadia
def: "a form of male hypospadia where the opening of the male urethra is located at the corona glandis" [https://www.statpearls.com/ArticleLibrary/viewarticle/26901]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:43:07Z" xsd:dateTime

[Term]
id: MP:0031299
name: subcoronal hypospadia
def: "a form of male hypospadia where the opening of the male urethra is located at the junction of the corona and the body of the penis" [https://www.dynamed.com/condition/hypospadias, https://www.statpearls.com/ArticleLibrary/viewarticle/26901]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:45:07Z" xsd:dateTime

[Term]
id: MP:0031300
name: perineal hypospadia
def: "a form of male hypospadia where the scrotum is abnormally divided (bifid) and the male urethral opening is located in the perineal region along the center of the divided sac" [https://nyulangone.org/conditions/hypospadias-in-children/types]
is_a: MP:0003124 ! hypospadia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-21T11:48:12Z" xsd:dateTime

[Term]
id: MP:0031301
name: chronic liver inflammation
def: "persistent inflammatory response in the liver, often caused by persistent infection or during an autoimmune response" [https://orcid.org/0000-0002-6490-7723]
synonym: "chronic hepatic inflammation" EXACT []
synonym: "chronic hepatitis" EXACT []
is_a: MP:0001860 ! liver inflammation
is_a: MP:0002499 ! chronic inflammation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-27T08:31:36Z" xsd:dateTime

[Term]
id: MP:0031302
name: syncope
def: "a transient loss of consciousness due to cerebral hypoperfusion with spontaneous return to baseline function without intervention" [PMID:27752576]
synonym: "fainting" BROAD []
synonym: "fainting spell" BROAD []
is_a: MP:0001544 ! abnormal cardiovascular system physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-09-27T09:16:42Z" xsd:dateTime

[Term]
id: MP:0031303
name: enhanced behavioral response to methamphetamine
def: "increased sensitivity to methamphetamine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced behavioural response to methamphetamine" EXACT []
is_a: MP:0012733 ! abnormal behavioral response to methamphetamine
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-04T11:22:00Z" xsd:dateTime

[Term]
id: MP:0031304
name: impaired behavioral response to methamphetamine
def: "decreased sensitivity to methamphetamine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [https://orcid.org/0000-0002-6490-7723]
synonym: "attenuated behavioral response to methamphetamine" EXACT []
synonym: "attenuated behavioural response to methamphetamine" EXACT []
synonym: "impaired behavioural response to methamphetamine" EXACT []
is_a: MP:0012733 ! abnormal behavioral response to methamphetamine
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-04T11:26:03Z" xsd:dateTime

[Term]
id: MP:0031305
name: preauricular skin tag
def: "a rudimentary tag of skin, that may also contain cartilage or fat, located in front of the auricle (outer part of the ear)" [HP:0000384, https://www.biologyonline.com/dictionary/preauricular, https://www.chop.edu/conditions-diseases/ear-tags]
synonym: "preauricular skin tags" EXACT []
synonym: "preauricular tag" EXACT []
synonym: "preauricular tags" EXACT []
synonym: "skin tag in front of the ear" BROAD []
is_a: MP:0030096 ! abnormal periauricular region morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T06:44:32Z" xsd:dateTime

[Term]
id: MP:0031306
name: abnormal cartilage physiology
def: "any functional anomaly of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "abnormal cartilage tissue physiology" EXACT []
is_a: MP:0001533 ! abnormal skeleton physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T08:00:59Z" xsd:dateTime

[Term]
id: MP:0031307
name: bronchomalacia
def: "a condition characterized by flaccidity of the bronchial support cartilage" [HP:0002780, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002133 ! abnormal respiratory system physiology
is_a: MP:0031306 ! abnormal cartilage physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T08:15:30Z" xsd:dateTime

[Term]
id: MP:0031308
name: tracheobronchomalacia
def: "a condition characterized by flaccidity of the tracheal and bronchial support cartilage" [HP:0002786, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013753 ! tracheomalacia
is_a: MP:0031307 ! bronchomalacia
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T08:33:28Z" xsd:dateTime

[Term]
id: MP:0031309
name: skin cyst
def: "presence of one or more abnormal membranous sacs in any portion of the skin" [https://orcid.org/0000-0002-6490-7723]
synonym: "cutaneous cyst" EXACT []
synonym: "cutaneous cysts" EXACT []
synonym: "cystic skin" EXACT []
synonym: "skin cysts" EXACT []
is_a: MP:0001191 ! abnormal skin condition
is_a: MP:0031310 ! abnormal cyst
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T09:47:29Z" xsd:dateTime

[Term]
id: MP:0031310
name: abnormal cyst
def: "presence of one or more abnormal membranous sacs in one or more organs or tissues of the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "cysts" EXACT []
is_a: MP:0005378 ! growth/size/body region phenotype
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-12T10:55:13Z" xsd:dateTime

[Term]
id: MP:0031312
name: spondylolysis
def: "a bony defect or stress fracture within the pars interarticularis of the vertebral arch in the spinal column; pars interarticularis is the part of a vertebra located between the inferior and superior articular processes of the facet joint" [https://en.wikipedia.org/wiki/Spondylolysis, https://www.spine-health.com/glossary/spondylolysis]
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T08:50:19Z" xsd:dateTime

[Term]
id: MP:0031313
name: spondylolisthesis
def: "a condition of the spine whereby one of the vertebra slips forward or backward in relation to the next vertebra; forward slippage of an upper vertebra on a lower vertebra is referred to as anterolisthesis, while backward slippage is referred to as retrolisthesis" [https://en.wikipedia.org/wiki/Spondylolisthesis, https://www.medicinenet.com/spondylolisthesis/article.htm]
comment: Spondylolisthesis can lead to a deformity of the spine as well as a narrowing of the spinal canal (central spinal stenosis) or compression of the exiting nerve roots (foraminal stenosis). Spondylolisthesis is most common in the low back (lumbar spine) but can also occur in the mid to upper back (thoracic spine) and neck (cervical spine).
synonym: "anterolisthesis" NARROW []
synonym: "retrolisthesis" NARROW []
synonym: "spondylolistheses" EXACT []
is_a: MP:0004703 ! abnormal vertebral column morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T09:40:22Z" xsd:dateTime

[Term]
id: MP:0031314
name: facial muscle weakness
def: "reduced strength of one or more of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII)" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased facial muscle strength" EXACT []
synonym: "reduced facial muscle strength" EXACT []
synonym: "weak facial muscle" EXACT []
synonym: "weak facial muscles" EXACT []
is_a: MP:0000747 ! muscle weakness
is_a: MP:0030144 ! abnormal facial muscle physiology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T10:24:25Z" xsd:dateTime

[Term]
id: MP:0031315
name: biliary atresia
def: "one or more bile ducts inside or outside the liver are abnormally narrow, blocked, or absent" [https://en.wikipedia.org/wiki/Biliary_atresia, https://medlineplus.gov/ency/article/001145.htm]
synonym: "biliary duct atresia" EXACT []
is_a: MP:0002928 ! abnormal bile duct morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T16:16:01Z" xsd:dateTime

[Term]
id: MP:0031316
name: lentiglobus
def: "globular projection of the anterior or posterior surface of the lens" [https://www.ufrgs.br/imunovet/molecular_immunology/senseorgans.html]
comment: Lentiglobus refers to a globular projection of the anterior or posterior surface of the lens, whereas lenticonus refers to a conical projection of the anterior or posterior surface of the lens.
synonym: "globoid shaped lens" EXACT [https://veterinaryophthalmicconsulting.com/pages/microphakia]
is_a: MP:0001303 ! abnormal lens morphology
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T16:28:48Z" xsd:dateTime

[Term]
id: MP:0031317
name: spherophakia
def: "a developmental defect in which a smaller, more spherical optic lens than normal is formed, with partial or complete aplasia of the zonule" [https://www.ufrgs.br/imunovet/molecular_immunology/senseorgans.html#spherophakia]
is_a: MP:0001306 ! small lens
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-10-25T16:41:42Z" xsd:dateTime

[Term]
id: MP:0031318
name: enhanced skeletal muscle regeneration
def: "increase in the renewal, repair, and/or regrowth of skeletal muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "improved skeletal muscle regeneration" EXACT []
synonym: "increased skeletal muscle regeneration" EXACT []
is_a: MP:0013161 ! enhanced muscle regeneration
is_a: MP:0013237 ! abnormal skeletal muscle regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-01T17:11:28Z" xsd:dateTime

[Term]
id: MP:0031319
name: impaired intestine regeneration
def: "decrease in the renewal, repair, and/or regrowth of intestinal tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased intestinal regeneration" EXACT []
synonym: "decreased intestine regeneration" EXACT []
synonym: "impaired intestinal regeneration" EXACT []
synonym: "reduced intestinal regeneration" EXACT []
synonym: "reduced intestine regeneration" EXACT []
is_a: MP:0003380 ! abnormal intestine regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-01T18:15:11Z" xsd:dateTime

[Term]
id: MP:0031320
name: enhanced intestine regeneration
def: "increase in the renewal, repair, and/or regrowth of intestinal tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced intestinal regeneration" EXACT []
synonym: "improved intestinal regeneration" EXACT []
synonym: "improved intestine regeneration" EXACT []
synonym: "increased intestinal regeneration" EXACT []
synonym: "increased intestine regeneration" EXACT []
is_a: MP:0003380 ! abnormal intestine regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-01T18:19:35Z" xsd:dateTime

[Term]
id: MP:0031321
name: enhanced cardiac muscle regeneration
def: "increase in the renewal, repair, and/or regrowth of cardiac muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced heart muscle regeneration" EXACT []
synonym: "improved cardiac muscle regeneration" EXACT []
synonym: "improved heart muscle regeneration" EXACT []
synonym: "increased cardiac muscle regeneration" EXACT []
synonym: "increased heart muscle regeneration" EXACT []
is_a: MP:0013161 ! enhanced muscle regeneration
is_a: MP:0013238 ! abnormal cardiac muscle regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-01T18:44:49Z" xsd:dateTime

[Term]
id: MP:0031322
name: decreased skeletal muscle satellite cell proliferation
def: "reduction in the expansion rate of a skeletal muscle satellite cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced skeletal muscle satellite cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0009410 ! abnormal skeletal muscle satellite cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T10:23:31Z" xsd:dateTime

[Term]
id: MP:0031323
name: increased skeletal muscle satellite cell proliferation
def: "increase in the expansion rate of a skeletal muscle satellite cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0009410 ! abnormal skeletal muscle satellite cell proliferation
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T10:36:41Z" xsd:dateTime

[Term]
id: MP:0031324
name: delayed liver regeneration
def: "late onset of the renewal, repair, and/or regrowth of liver tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed hepatic regeneration" EXACT []
is_a: MP:0002658 ! abnormal liver regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T11:38:22Z" xsd:dateTime

[Term]
id: MP:0031325
name: delayed pancreas regeneration
def: "late onset of the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed pancreatic regeneration" EXACT []
is_a: MP:0005518 ! abnormal pancreas regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T11:45:50Z" xsd:dateTime

[Term]
id: MP:0031326
name: delayed muscle regeneration
def: "late onset of the renewal, repair, and/or regrowth of muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000750 ! abnormal muscle regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T12:04:05Z" xsd:dateTime

[Term]
id: MP:0031327
name: delayed cardiac muscle regeneration
def: "late onset of the renewal, repair, and/or regrowth of cardiac muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed heart muscle regeneration" EXACT []
is_a: MP:0013238 ! abnormal cardiac muscle regeneration
is_a: MP:0031326 ! delayed muscle regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T12:08:54Z" xsd:dateTime

[Term]
id: MP:0031328
name: delayed skeletal muscle regeneration
def: "late onset of the renewal, repair, and/or regrowth of skeletal muscle tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0013237 ! abnormal skeletal muscle regeneration
is_a: MP:0031326 ! delayed muscle regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T12:16:35Z" xsd:dateTime

[Term]
id: MP:0031329
name: delayed central nervous system regeneration
def: "late onset of the renewal, repair, and/or regrowth of central nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed CNS regeneration" EXACT []
is_a: MP:0003407 ! abnormal central nervous system regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T12:51:40Z" xsd:dateTime

[Term]
id: MP:0031330
name: delayed peripheral nervous system regeneration
def: "late onset of the renewal, repair, and/or regrowth of peripheral nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed PNS regeneration" EXACT []
is_a: MP:0004220 ! abnormal peripheral nervous system regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T12:56:40Z" xsd:dateTime

[Term]
id: MP:0031331
name: delayed intestine regeneration
def: "late onset of the renewal, repair, and/or regrowth of intestinal tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "delayed intestinal regeneration" EXACT []
is_a: MP:0003380 ! abnormal intestine regeneration
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T13:01:56Z" xsd:dateTime

[Term]
id: MP:0031332
name: abnormal inhibitory postsynaptic current amplitude
def: "anomaly in the size (height or maximum displacement) or shape of the evoked inhibitory postsynaptic current wave" [https://orcid.org/0000-0002-4154-7358]
synonym: "abnormal inhibitory post-synaptic current amplitude" EXACT []
is_a: MP:0002945 ! abnormal inhibitory postsynaptic currents
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T14:06:56Z" xsd:dateTime

[Term]
id: MP:0031333
name: decreased inhibitory postsynaptic current amplitude
def: "reduction in the size (height or maximum displacement) of the evoked inhibitory postsynaptic current wave" [https://orcid.org/0000-0002-4154-7358]
synonym: "decreased inhibitory post-synaptic current amplitude" EXACT []
synonym: "reduced inhibitory post-synaptic current amplitude" EXACT []
synonym: "reduced inhibitory postsynaptic current amplitude" EXACT []
is_a: MP:0031332 ! abnormal inhibitory postsynaptic current amplitude
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T14:14:40Z" xsd:dateTime

[Term]
id: MP:0031334
name: increased inhibitory postsynaptic current amplitude
def: "increase in the size (height or maximum displacement) of the evoked inhibitory postsynaptic current wave" [https://orcid.org/0000-0002-4154-7358]
synonym: "increased inhibitory post-synaptic current amplitude" EXACT []
is_a: MP:0031332 ! abnormal inhibitory postsynaptic current amplitude
property_value: dc:creator https://orcid.org/0000-0002-6490-7723
property_value: dc:date "2021-11-15T14:19:46Z" xsd:dateTime

[Term]
id: MP:0031336
name: abnormal uterine epithelium development
def: "any anomaly in the progression of an epithelium of the uterus over time from its initial formation to the mature structure" [GO:0035847, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal uterine epithelial development" EXACT []
synonym: "abnormal uterus epithelial development" EXACT []
synonym: "abnormal uterus epithelium development" EXACT []
is_a: MP:0003572 ! abnormal uterus development
property_value: dc:date "2021-12-13T11:16:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031337
name: abnormal lipocalin 2 level
def: "any anomaly in the amount of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal LCN2 level" EXACT []
synonym: "abnormal neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "abnormal NGAL level" EXACT []
is_a: MP:0008469 ! abnormal protein level
property_value: dc:date "2021-12-13T12:37:03Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031338
name: decreased lipocalin 2 level
def: "reduction in the amount of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased LCN2 level" EXACT []
synonym: "decreased neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "decreased NGAL level" EXACT []
synonym: "reduced LCN2 level" EXACT []
synonym: "reduced lipocalin 2 level" EXACT []
synonym: "reduced neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "reduced NGAL level" EXACT []
is_a: MP:0031337 ! abnormal lipocalin 2 level
property_value: dc:date "2021-12-13T12:43:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031339
name: increased lipocalin 2 level
def: "increase in the amount of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "elevated LCN2 level" EXACT []
synonym: "elevated lipocalin 2 level" EXACT []
synonym: "increased LCN2 level" EXACT []
synonym: "increased neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "increased NGAL level" EXACT []
is_a: MP:0031337 ! abnormal lipocalin 2 level
property_value: dc:date "2021-12-13T13:03:45Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031340
name: abnormal circulating lipocalin 2 level
def: "any anomaly in the amount in the blood of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal circulating LCN2 level" EXACT []
synonym: "abnormal circulating neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "abnormal circulating NGAL level" EXACT []
synonym: "abnormal plasma lipocalin 2 level" NARROW []
synonym: "abnormal serum lipocalin 2 level" NARROW []
is_a: MP:0005416 ! abnormal circulating protein level
is_a: MP:0031337 ! abnormal lipocalin 2 level
property_value: dc:date "2021-12-13T13:15:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031341
name: decreased circulating lipocalin 2 level
def: "reduction in the amount in the blood of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased circulating LCN2 level" EXACT []
synonym: "decreased circulating neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "decreased circulating NGAL level" EXACT []
synonym: "decreased plasma lipocalin 2 level" NARROW []
synonym: "decreased serum lipocalin 2 level" NARROW []
synonym: "reduced circulating LCN2 level" EXACT []
synonym: "reduced circulating lipocalin 2 level" EXACT []
synonym: "reduced circulating neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "reduced circulating NGAL level" EXACT []
synonym: "reduced plasma lipocalin 2 level" NARROW []
synonym: "reduced serum lipocalin 2 level" NARROW []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031338 ! decreased lipocalin 2 level
is_a: MP:0031340 ! abnormal circulating lipocalin 2 level
property_value: dc:date "2021-12-13T13:19:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031342
name: increased circulating lipocalin 2 level
def: "increase in the amount in the blood of lipocalin 2, a protein that plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores" [https://en.wikipedia.org/wiki/Lipocalin-2, https://orcid.org/0000-0002-6490-7723]
synonym: "elevated circulating LCN2 level" EXACT []
synonym: "elevated circulating lipocalin 2 level" EXACT []
synonym: "increased circulating LCN2 level" EXACT []
synonym: "increased circulating neutrophil gelatinase-associated lipocalin level" EXACT []
synonym: "increased circulating NGAL level" EXACT []
synonym: "increased plasma lipocalin 2 level" NARROW []
synonym: "increased serum lipocalin 2 level" NARROW []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031339 ! increased lipocalin 2 level
is_a: MP:0031340 ! abnormal circulating lipocalin 2 level
property_value: dc:date "2021-12-13T13:26:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031343
name: colon atresia
def: "congenital blockage or absence of the lumen of the colon" [https://orcid.org/0000-0002-6490-7723]
synonym: "colonic atresia" EXACT []
is_a: MP:0000495 ! abnormal colon morphology
property_value: dc:date "2021-12-20T14:28:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031344
name: aortic bulb aneurysm
def: "a protruding sac formed by the dilation of the wall of the aortic bulb resulting from a weakening of the vessel wall" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic root aneurysm" EXACT []
is_a: MP:0010661 ! ascending aorta aneurysm
is_a: MP:0011575 ! dilated aorta bulb
property_value: dc:date "2022-01-31T14:13:21Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031345
name: developmental cataract
def: "a lens opacity that is present before or at birth" [https://orcid.org/0000-0002-6490-7723]
synonym: "congenital cataract" EXACT []
synonym: "congenital cataracts" EXACT []
synonym: "developmental cataracts" EXACT []
is_a: MP:0001304 ! cataract
property_value: dc:date "2022-02-01T08:33:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031346
name: abnormal eye vasculature morphology
def: "any anomaly of the structure or arrangement of blood vessels supplying the eye" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal eye blood vessel morphology" EXACT []
synonym: "abnormal ocular blood vessel morphology" EXACT []
synonym: "abnormal ocular vasculature morphology" EXACT []
is_a: MP:0001614 ! abnormal blood vessel morphology
is_a: MP:0002092 ! abnormal eye morphology
property_value: dc:date "2022-02-01T09:08:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031347
name: red eye
def: "a condition where the white part of the eye (sclera) appears reddened or bloodshot, ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera" [HP:0025337, https://medlineplus.gov/ency/article/003031.htm]
comment: This term should be used for vascular related redness, not the red eyes seen in albinism.
synonym: "red eyes" EXACT []
is_a: MP:0031346 ! abnormal eye vasculature morphology
property_value: dc:date "2022-02-01T09:42:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031348
name: bone fibrous dysplasia
def: "normal bone and marrow is replaced with scar-like (fibrous) connective tissue, resulting in formation of bone that is weak and prone to expansion" [https://en.wikipedia.org/wiki/Fibrous_dysplasia_of_bone, https://rarediseases.org/rare-diseases/fibrous-dysplasia/]
synonym: "fibrous dysplasia of bone" EXACT []
is_a: MP:0003795 ! abnormal bone structure
property_value: dc:date "2022-02-01T10:29:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031349
name: monostotic fibrous dysplasia
def: "a form of fibrous dysplasia affecting one solitary bone" [https://rarediseases.org/rare-diseases/fibrous-dysplasia/]
is_a: MP:0031348 ! bone fibrous dysplasia
property_value: dc:date "2022-02-01T10:34:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031350
name: polyostotic fibrous dysplasia
def: "a form of fibrous dysplasia affecting multiple bones throughout the body" [https://rarediseases.org/rare-diseases/fibrous-dysplasia/]
is_a: MP:0031348 ! bone fibrous dysplasia
property_value: dc:date "2022-02-01T10:37:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031351
name: abnormal sperm flagellum thickness
def: "any anomaly in the distance across the short axis of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008892 ! abnormal sperm flagellum morphology
property_value: dc:date "2022-02-07T12:41:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031352
name: absent sperm axonemal central pair
def: "missing the central pair of microtubules in the sperm axoneme, thereby forming a 9 + 0 pattern instead of the normal 9 + 2 pattern" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent sperm axonemal microtubule central pair" EXACT []
synonym: "absent sperm axoneme central pair" EXACT []
is_a: MP:0009838 ! abnormal sperm axoneme morphology
property_value: dc:date "2022-02-07T14:18:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031353
name: abnormal testis apoptosis
def: "change in the timing or the number of cells in testicular tissue undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal testicular apoptosis" EXACT []
is_a: MP:0004884 ! abnormal testis physiology
property_value: dc:date "2022-02-07T14:45:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031354
name: abnormal acrosome assembly
def: "any anomaly in the formation of the acrosome from the spermatid Golgi" [GO:0001675, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal acrosome biogenesis" RELATED []
synonym: "abnormal acrosome formation" EXACT []
is_a: MP:0001932 ! abnormal spermiogenesis
is_a: MP:0008898 ! abnormal acrosome morphology
property_value: dc:date "2022-02-14T10:06:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031355
name: abnormal proacrosomal vesicle fusion
def: "any anomaly in the fusion of the membrane of a proacrosomal vesicle with the membrane of another proacrosomal vesicle to form a single large acrosomal granule at the nuclear surface" [GO:0120211, PMID:31620437]
is_a: MP:0031354 ! abnormal acrosome assembly
property_value: dc:date "2022-02-14T10:58:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031356
name: abnormal outer dense fiber morphology
def: "any structural anomaly of the highly condensed, modified intermediate cytoskeletal filaments strengthened by disulfide linked keratin proteins that progress from the midpiece to the principal piece of the sperm tail; outer dense fibers are believed to maintain flagellar elasticity and play a role in the protection of the sperm tail against shear forces during epididymal transport and ejaculation" [https://royalsocietypublishing.org/doi/10.1098/rsif.2018.0668, PMID:29168316]
comment: In the mammalian sperm tail, each ODF, which is numbered from 1 to 9 according to differences in cross-sectional shape and size, connects with one microtubular doublet of the axoneme resulting in a 9 + 9 + 2 cross-sectional pattern. In the principal piece, the fibrous sheath replaces ODFs 3 and 8, and the sizes of other ODFs progressively decrease distally. The shapes, sizes and lengths of ODFs are quite distinct in different species. {xref="PMID:29168316"}
synonym: "abnormal ODF morphology" EXACT []
synonym: "abnormal outer dense fibre morphology" EXACT []
is_a: MP:0008892 ! abnormal sperm flagellum morphology
property_value: dc:date "2022-02-14T12:57:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031357
name: enlarged prostate gland ventral lobe
def: "increased size of the rodent prostate lobe that is located below the ventral aspect of the bladder neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged ventral prostate gland" EXACT []
synonym: "increased prostate gland ventral lobe size" EXACT []
synonym: "large ventral prostate gland" EXACT []
synonym: "large VP" EXACT []
is_a: MP:0009380 ! abnormal prostate gland ventral lobe morphology
property_value: dc:date "2022-02-14T15:42:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031358
name: decreased urine output
def: "a reduction in the volume of urine produced and excreted or the absence of urine production and excretion" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urine volume" EXACT []
synonym: "reduced urine output" EXACT []
synonym: "reduced urine volume" EXACT []
is_a: MP:0001756 ! abnormal urination
property_value: dc:date "2022-02-14T17:39:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031359
name: decreased prostate gland anterior lobe weight
def: "reduction in the average weight of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased anterior prostate lobe weight" EXACT []
synonym: "decreased anterior prostate weight" EXACT []
synonym: "decreased AP weight" EXACT []
synonym: "decreased CG weight" EXACT []
synonym: "decreased coagulating gland weight" EXACT []
synonym: "reduced anterior prostate lobe weight" EXACT []
synonym: "reduced anterior prostate weight" EXACT []
synonym: "reduced AP weight" EXACT []
synonym: "reduced CG weight" EXACT []
synonym: "reduced coagulating gland weight" EXACT []
synonym: "reduced prostate gland anterior lobe weight" EXACT []
is_a: MP:0000664 ! small prostate gland anterior lobe
is_a: MP:0004960 ! abnormal prostate gland weight
property_value: dc:date "2022-02-15T09:52:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031360
name: prostate gland anterior lobe hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the prostate gland anterior lobe, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "anterior prostate hypoplasia" EXACT []
synonym: "AP hypoplasia" EXACT []
synonym: "CG hypoplasia" EXACT []
synonym: "coagulating gland hypoplasia" EXACT []
synonym: "hypoplastic anterior prostate lobe" EXACT []
synonym: "hypoplastic coagulating gland" EXACT []
synonym: "hypoplastic prostate gland anterior lobe" EXACT []
is_a: MP:0000664 ! small prostate gland anterior lobe
property_value: dc:date "2022-02-15T10:08:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031361
name: increased prostate gland anterior lobe weight
def: "increase in the average weight of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased anterior prostate lobe weight" EXACT []
synonym: "increased AP weight" EXACT []
synonym: "increased CG weight" EXACT []
synonym: "increased coagulating gland weight" EXACT []
is_a: MP:0004960 ! abnormal prostate gland weight
is_a: MP:0009738 ! enlarged prostate gland anterior lobe
property_value: dc:date "2022-02-15T10:18:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031362
name: decreased prostate gland ventral lobe weight
def: "reduction in the average weight of the rodent prostate lobe that is located below the ventral aspect of the bladder neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ventral prostate lobe weight" EXACT []
synonym: "decreased VP weight" EXACT []
synonym: "reduced prostate gland ventral lobe weight" EXACT []
synonym: "reduced ventral prostate lobe weight" EXACT []
synonym: "reduced VP weight" EXACT []
is_a: MP:0000661 ! small prostate gland ventral lobe
is_a: MP:0004960 ! abnormal prostate gland weight
property_value: dc:date "2022-02-15T10:27:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031363
name: prostate gland ventral lobe hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the prostate gland ventral lobe, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic prostate gland ventral lobe" EXACT []
synonym: "hypoplastic ventral prostate lobe" EXACT []
synonym: "ventral prostate hypoplasia" EXACT []
synonym: "VP hypoplasia" EXACT []
is_a: MP:0000661 ! small prostate gland ventral lobe
property_value: dc:date "2022-02-15T10:33:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031364
name: increased prostate gland ventral lobe weight
def: "increase in the average weight of the rodent prostate lobe that is located below the ventral aspect of the bladder neck" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased ventral prostate lobe weight" EXACT []
synonym: "increased VP weight" EXACT []
is_a: MP:0004960 ! abnormal prostate gland weight
is_a: MP:0031357 ! enlarged prostate gland ventral lobe
property_value: dc:date "2022-02-15T10:41:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031365
name: prostate gland ventral lobe hyperplasia
def: "increase in the number of normal cells in normal arrangement in the prostate gland ventral lobe, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic prostate gland ventral lobe" EXACT []
synonym: "hyperplastic ventral prostate lobe" EXACT []
synonym: "ventral prostate hyperplasia" EXACT []
synonym: "VP hyperplasia" EXACT []
is_a: MP:0031357 ! enlarged prostate gland ventral lobe
property_value: dc:date "2022-02-15T10:45:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031366
name: decreased prostate gland dorsolateral lobe weight
def: "reduction in the average weight of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased DLP weight" EXACT []
synonym: "decreased dorsolateral prostate lobe weight" EXACT []
synonym: "reduced DLP weight" EXACT []
synonym: "reduced dorsolateral prostate lobe weight" EXACT []
synonym: "reduced prostate gland dorsolateral lobe weight" EXACT []
is_a: MP:0004960 ! abnormal prostate gland weight
is_a: MP:0009740 ! small prostate gland dorsolateral lobe
property_value: dc:date "2022-02-15T10:51:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031367
name: prostate gland dorsolateral lobe hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the prostate gland dorsolateral lobe, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "DLP hypoplasia" EXACT []
synonym: "dorsolateral prostate hypoplasia" EXACT []
synonym: "hypoplastic dorsolateral prostate lobe" EXACT []
synonym: "hypoplastic prostate gland dorsolateral lobe" EXACT []
is_a: MP:0009740 ! small prostate gland dorsolateral lobe
property_value: dc:date "2022-02-15T10:56:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031368
name: increased prostate gland dorsolateral lobe weight
def: "increase in the average weight of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased DLP weight" EXACT []
synonym: "increased dorsolateral prostate lobe weight" EXACT []
is_a: MP:0004960 ! abnormal prostate gland weight
is_a: MP:0009739 ! enlarged prostate gland dorsolateral lobe
property_value: dc:date "2022-02-15T11:00:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031369
name: prostate gland dorsolateral lobe hyperplasia
def: "increase in the number of normal cells in normal arrangement in the prostate gland dorsolateral lobe, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "DLP hyperplasia" EXACT []
synonym: "dorsolateral prostate hyperplasia" EXACT []
synonym: "hyperplastic dorsolateral prostate lobe" EXACT []
synonym: "hyperplastic prostate gland dorsolateral lobe" EXACT []
is_a: MP:0009739 ! enlarged prostate gland dorsolateral lobe
property_value: dc:date "2022-02-15T11:06:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031372
name: abnormal sperm individualization
def: "anomaly in the resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane" [GO:0007291]
is_a: MP:0001932 ! abnormal spermiogenesis
property_value: dc:date "2022-02-28T11:03:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031373
name: abnormal manchette perinuclear ring morphology
def: "any structural morphology of the ring-like portion of the manchette that surrounds the base of the elongating spermatid nucleus below the acroplaxome marginal ring and plays a key role in shaping the nucleus and the sperm head; microtubules extend from the perinuclear ring into the cytoplasm and/or basal body of the spermatid" [PMID:22366765, PMID:33144677]
comment: Although the perinuclear ring is regarded as the microtubule-organizing center for the manchette, findings about the nucleation site and the direction of microtubules are inconsistent. During spermatid differentiation, the manchette moves toward the tail neck region, with constriction of the perinuclear ring, which contributes to sculpting of the sperm head in mice. {xref="PMID:33144677"}
is_a: MP:0009376 ! abnormal manchette morphology
property_value: dc:date "2022-03-14T12:21:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031374
name: abnormal manchette assembly
def: "any anomaly in the aggregation, arrangement and/or bonding together of a set of components to form a manchette" [GO:1905198]
synonym: "abnormal manchette formation" EXACT []
is_a: MP:0001932 ! abnormal spermiogenesis
is_a: MP:0009376 ! abnormal manchette morphology
property_value: dc:date "2022-03-14T13:06:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031375
name: abnormal manchette disassembly
def: "any anomaly in the disaggregation of a manchette into its constituent components" [GO:1905199]
is_a: MP:0001932 ! abnormal spermiogenesis
is_a: MP:0009376 ! abnormal manchette morphology
property_value: dc:date "2022-03-14T13:46:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031376
name: abnormal acrosomal vesicle exocytosis
def: "anomaly in the calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction" [GO:0060478]
synonym: "abnormal acrosomal granule exocytosis" RELATED []
synonym: "abnormal acrosome exocytosis" EXACT []
is_a: MP:0013287 ! abnormal acrosome reaction
is_a: MP:0020848 ! abnormal exocytosis
property_value: dc:date "2022-03-14T16:46:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031377
name: ambiguous external genitalia
def: "an external genital phenotype that is not clearly assignable to a single sex" [HP:0000062]
synonym: "ambiguous genitalia" BROAD []
synonym: "indeterminate external genitalia" EXACT []
is_a: MP:0002160 ! abnormal reproductive system morphology
property_value: dc:date "2022-03-14T18:47:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031378
name: ambiguous external male genitalia
def: "ambiguous external genitalia in an organism with XY genetic sex" [HP:0000033]
synonym: "ambiguous external genitalia in males" EXACT []
is_a: MP:0009199 ! abnormal external male genitalia morphology
is_a: MP:0031377 ! ambiguous external genitalia
property_value: dc:date "2022-03-14T18:57:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031379
name: ambiguous external female genitalia
def: "ambiguous external genitalia in an organism with XX genetic sex" [HP:0000061]
synonym: "ambiguous external genitalia in females" EXACT []
is_a: MP:0003126 ! abnormal external female genitalia morphology
is_a: MP:0031377 ! ambiguous external genitalia
property_value: dc:date "2022-03-14T19:02:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031380
name: abnormal secondary ovarian follicle number
def: "abnormal numbers of the maturing ovarian follicle that has two or more layers of granulosa cells but lacks antra" [UBERON:0000036]
synonym: "abnormal folliculus ovaricus secondarius number" EXACT []
synonym: "abnormal pre-antral follicle number" EXACT []
synonym: "abnormal preantral follicle number" EXACT []
is_a: MP:0008871 ! abnormal ovarian follicle number
is_a: MP:0021106 ! abnormal secondary ovarian follicle morphology
property_value: dc:date "2022-03-16T10:48:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031381
name: decreased secondary ovarian follicle number
def: "fewer than normal numbers of the maturing ovarian follicle that has two or more layers of granulosa cells but lacks antra" [UBERON:0000036]
synonym: "decreased folliculus ovaricus secondarius number" EXACT []
synonym: "decreased pre-antral follicle number" EXACT []
synonym: "decreased preantral follicle number" EXACT []
synonym: "reduced folliculus ovaricus secondarius number" EXACT []
synonym: "reduced pre-antral follicle number" EXACT []
synonym: "reduced preantral follicle number" EXACT []
synonym: "reduced secondary ovarian follicle number" EXACT []
is_a: MP:0031380 ! abnormal secondary ovarian follicle number
property_value: dc:date "2022-03-16T11:06:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031382
name: absent secondary ovarian follicles
def: "absence of the maturing ovarian follicle that has two or more layers of granulosa cells but lacks antra" [UBERON:0000036]
synonym: "absent folliculus ovaricus secondarius" EXACT []
synonym: "absent pre-antral follicles" EXACT []
synonym: "absent preantral follicles" EXACT []
is_a: MP:0031381 ! decreased secondary ovarian follicle number
property_value: dc:date "2022-03-16T11:21:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031383
name: increased secondary ovarian follicle number
def: "greater than normal numbers of the maturing ovarian follicle that has two or more layers of granulosa cells but lacks antra" [UBERON:0000036]
synonym: "increased folliculus ovaricus secondarius number" EXACT []
synonym: "increased pre-antral follicle number" EXACT []
synonym: "increased preantral follicle number" EXACT []
is_a: MP:0031380 ! abnormal secondary ovarian follicle number
property_value: dc:date "2022-03-16T11:29:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031384
name: impaired blood-brain barrier function
def: "reduced ability of the group of barriers and transport systems in the brain capillary endothelium to control the entry of substances into the brain extracellular space from the blood" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "impaired BBB function" EXACT []
synonym: "increased BBB leakage" EXACT []
synonym: "increased BBB permeability" EXACT []
synonym: "increased blood-brain barrier leakage" EXACT []
synonym: "increased blood-brain barrier permeability" EXACT []
synonym: "leaky blood-brain barrier" EXACT []
is_a: MP:0005167 ! abnormal blood-brain barrier function
property_value: dc:date "2022-03-21T16:35:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031385
name: enhanced blood-brain barrier function
def: "increased ability of the group of barriers and transport systems in the brain capillary endothelium to control the entry of substances into the brain extracellular space from the blood" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased BBB leakage" EXACT []
synonym: "decreased BBB permeability" EXACT []
synonym: "decreased blood-brain barrier leakage" EXACT []
synonym: "decreased blood-brain barrier permeability" EXACT []
synonym: "enhanced BBB function" EXACT []
synonym: "improved BBB function" EXACT []
synonym: "improved blood-brain barrier function" EXACT []
synonym: "reduced BBB leakage" EXACT []
synonym: "reduced BBB permeability" EXACT []
synonym: "reduced blood-brain barrier leakage" EXACT []
synonym: "reduced blood-brain barrier permeability" EXACT []
is_a: MP:0005167 ! abnormal blood-brain barrier function
property_value: dc:date "2022-03-21T16:42:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031386
name: elongated manchette
def: "increased distance between the perinuclear ring of the manchette and the posterior portion of the spermatid nucleus" [PMID:22654669]
synonym: "increased manchette length" EXACT []
synonym: "long manchette" EXACT []
synonym: "manchette elongation" EXACT []
is_a: MP:0009376 ! abnormal manchette morphology
property_value: dc:date "2022-03-24T09:08:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031387
name: abnormal intramanchette transport
def: "anomaly in the movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments" [GO:1990953]
synonym: "abnormal IMT" EXACT []
is_a: MP:0001932 ! abnormal spermiogenesis
property_value: dc:date "2022-03-24T10:45:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031388
name: absent manchette
def: "absence of the conic array of microtubules that invests the posterior nucleus of a spermatid and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0009376 ! abnormal manchette morphology
property_value: dc:date "2022-03-24T11:13:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031389
name: abnormal ectoplasmic specialization morphology
def: "any structural anomaly of the testis-specific adheren junctions that are present during the seminiferous epithelial cycle of spermatogenesis at the Sertoli-Sertoli cell interface (known as the basal ES at the blood-testis barrier) or at the Sertoli-elongating spermatid interface (known as the apical ES in the adluminal compartment)" [PMID:18068662, PMID:23546604]
synonym: "abnormal ectoplasmic specialisation morphology" EXACT []
is_a: MP:0011750 ! abnormal seminiferous tubule epithelium morphology
property_value: dc:date "2022-03-24T15:02:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031390
name: myometrium hyperplasia
def: "increase in the number of normal cells in normal arrangement in the myometrium, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic myometrium" EXACT []
synonym: "myometrial hyperplasia" EXACT []
synonym: "uterine smooth muscle hyperplasia" EXACT []
synonym: "uterus smooth muscle hyperplasia" EXACT []
is_a: MP:0008256 ! abnormal myometrium morphology
property_value: dc:date "2022-03-31T14:43:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031391
name: increased locomotor activity
def: "general increase in locomotor activity; increased movement from one place to another" [https://orcid.org/0000-0002-6490-7723]
synonym: "high spontaneous locomotor activity" EXACT []
synonym: "hyperlocomotion" EXACT []
synonym: "increased activity in horizontal open field test" EXACT []
synonym: "increased spontaneous locomotor activity" EXACT []
synonym: "wild running" EXACT []
is_a: MP:0001392 ! abnormal locomotor behavior
is_a: MP:0001399 ! hyperactivity
property_value: dc:date "2022-04-04T12:34:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031392
name: hypoactivity
def: "general reduction in the movement of the body or any of its parts" [https://orcid.org/0000-0002-6490-7723, NBO:0000338]
synonym: "decreased physical activity" EXACT []
synonym: "hypoactive" EXACT []
synonym: "reduced physical activity" EXACT []
synonym: "underactive" EXACT []
is_a: MP:0003491 ! abnormal voluntary movement
property_value: dc:date "2022-04-04T13:50:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031393
name: abnormal bicarbonate homeostasis
def: "anomaly in the processes involved in the maintenance of an internal equilibrium of bicarbonate within the body or between a cell and its external environment; bicarbonate is a polyatomic anion with the chemical formula HCO3- that serves a crucial role in the physiological pH buffering system" [CHEBI:17544, https://orcid.org/0000-0002-6490-7723]
comment: IUPAC (International Union of Pure and Applied Chemistry)-recommended nomenclature is hydrogencarbonate with the chemical formula CHO3.
synonym: "abnormal HCO3- homeostasis" EXACT []
synonym: "abnormal hydrogencarbonate homeostasis" EXACT []
is_a: MP:0001765 ! abnormal ion homeostasis
property_value: dc:date "2022-04-18T11:32:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031394
name: abnormal bicarbonate level
def: "any anomaly in the concentration of bicarbonate in the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal HCO3- level" EXACT []
synonym: "abnormal hydrogencarbonate level" EXACT []
is_a: MP:0031393 ! abnormal bicarbonate homeostasis
property_value: dc:date "2022-04-18T11:42:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031395
name: cutaneous mastocytosis
def: "presence of excess mast cell numbers in any portion of the skin" [https://orcid.org/0000-0002-6490-7723]
comment: Cutaneous mastocytosis is limited to the skin whereas systemic mastocytosis affects extracutaneous tissues (such as spleen, liver, bone marrow, and lymph nodes) in addition to skin. {xref="https://www.uptodate.com/contents/mastocytosis-cutaneous-and-systemic-in-children-epidemiology-clinical-manifestations-evaluation-and-diagnosis", xref="https://www.mdpi.com/2077-0383/10/7/1474/htm"}
synonym: "increased cutaneous mast cell number" EXACT []
synonym: "increased mast cell number in the skin" EXACT []
synonym: "increased skin mast cell number" EXACT []
is_a: MP:0000324 ! increased mast cell number
property_value: dc:date "2022-04-18T14:25:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031396
name: abnormal aspartoacylase level
def: "any anomaly in the concentration of the enzyme that catalyzes the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate" [GO:0019807, https://orcid.org/0000-0003-3645-6803, PMID:10820213]
synonym: "aberrant aspartoacylase level" EXACT []
synonym: "abnormal acetyl-aspartic deaminase level" EXACT []
synonym: "abnormal acylase II level" EXACT []
synonym: "abnormal aminoacylase II level" EXACT []
synonym: "abnormal N-acetylaspartate amidohydrolase level" EXACT []
synonym: "abnormal N-acyl-L-aspartate amidohydrolase level" EXACT []
synonym: "altered aspartoacylase level" EXACT []
is_a: MP:0005319 ! abnormal enzyme/coenzyme level
property_value: dc:date "2022-05-16T07:27:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031397
name: increased aspartoacylase level
def: "elevated concentration of the enzyme that catalyzes the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate" [GO:0019807, https://orcid.org/0000-0003-3645-6803, PMID:10820213]
synonym: "elevated aspartoacylase level" EXACT []
synonym: "increased acetyl-aspartic deaminase level" EXACT []
synonym: "increased acylase II level" EXACT []
synonym: "increased aminoacylase II level" EXACT []
synonym: "increased N-acetylaspartate amidohydrolase level" EXACT []
synonym: "increased N-acyl-L-aspartate amidohydrolase level" EXACT []
is_a: MP:0014448 ! increased enzyme/coenzyme level
is_a: MP:0031396 ! abnormal aspartoacylase level
property_value: dc:date "2022-05-16T07:57:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031398
name: decreased aspartoacylase level
def: "reduced concentration of the enzyme that catalyzes the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate" [GO:0019807, https://orcid.org/0000-0003-3645-6803, PMID:10820213]
synonym: "decreased acetyl-aspartic deaminase level" EXACT []
synonym: "decreased acylase II level" EXACT []
synonym: "decreased aminoacylase II level" EXACT []
synonym: "decreased N-acetylaspartate amidohydrolase level" EXACT []
synonym: "decreased N-acyl-L-aspartate amidohydrolase level" EXACT []
synonym: "reduced acetyl-aspartic deaminase level" EXACT []
synonym: "reduced acylase II level" EXACT []
synonym: "reduced aminoacylase II level" EXACT []
synonym: "reduced aspartoacylase level" EXACT []
synonym: "reduced N-acetylaspartate amidohydrolase level" EXACT []
synonym: "reduced N-acyl-L-aspartate amidohydrolase level" EXACT []
is_a: MP:0014449 ! decreased enzyme/coenzyme level
is_a: MP:0031396 ! abnormal aspartoacylase level
property_value: dc:date "2022-05-16T08:10:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031399
name: early balanopreputial separation
def: "the separation of the prepuce from the glans penis (balanus), a result of the cornification of the balano-preputial epithelium, occurs at an earlier than expected age" [PMID:889997]
comment: Balanopreputial separation is used as an index for the onset of male puberty and is androgen-sensitive in the rat {comment="PMID:889997"}
synonym: "early balano-preputial separation" EXACT []
synonym: "early onset of balano-preputial separation" EXACT []
synonym: "early onset of balanopreputial separation" EXACT []
synonym: "early onset of preputial separation" EXACT []
synonym: "early preputial separation" EXACT []
synonym: "precocious balano-preputial separation" EXACT []
synonym: "precocious balanopreputial separation" EXACT []
synonym: "precocious preputial separation" EXACT []
is_a: MP:0003378 ! early sexual maturation
property_value: dc:date "2022-05-16T09:15:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031400
name: decreased esophagus squamous cell carcinoma incidence
def: "less than the expected number of esophageal carcinomas derived from stratified squamous epithelium, occurring in a specific population in a given time period" [https://orcid.org/0000-0001-5256-8683, https://orcid.org/0000-0002-6490-7723, PMID:32123074]
synonym: "decreased esophageal squamous cell carcinoma incidence" EXACT []
synonym: "decreased oesophageal squamous cell carcinoma incidence" EXACT []
synonym: "decreased oesophagus squamous cell carcinoma incidence" EXACT []
synonym: "reduced esophageal squamous cell carcinoma incidence" EXACT []
synonym: "reduced esophagus squamous cell carcinoma incidence" EXACT []
synonym: "reduced oesophageal squamous cell carcinoma incidence" EXACT []
synonym: "reduced oesophagus squamous cell carcinoma incidence" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0010283 ! decreased classified tumor incidence
is_a: MP:0012424 ! decreased alimentary system tumor incidence
property_value: dc:date "2022-05-16T10:32:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031401
name: increased esophagus squamous cell carcinoma incidence
def: "greater than the expected number of esophageal carcinomas derived from stratified squamous epithelium, occurring in a specific population in a given time period" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased esophageal squamous cell carcinoma incidence" EXACT []
synonym: "increased oesophageal squamous cell carcinoma incidence" EXACT []
synonym: "increased oesophagus squamous cell carcinoma incidence" EXACT []
is_a: MP:0000467 ! abnormal esophagus morphology
is_a: MP:0004207 ! increased squamous cell carcinoma incidence
is_a: MP:0010292 ! increased alimentary system tumor incidence
property_value: dc:date "2022-05-16T10:44:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031402
name: decreased muscle fatigability
def: "decreased muscle exhaustion or decreased susceptibility to muscle exhaustion" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased muscle fatiguability" EXACT []
synonym: "decreased susceptibility to muscle fatigue" EXACT []
synonym: "increased resistance to muscle fatigue" EXACT []
synonym: "reduced muscle fatigability" EXACT []
synonym: "reduced muscle fatiguability" EXACT []
synonym: "reduced susceptibility to muscle fatigue" EXACT []
is_a: MP:0002106 ! abnormal muscle physiology
property_value: dc:date "2022-05-16T11:36:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031404
name: increased tubuloglomerular feedback response
def: "enhancement of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa" [https://orcid.org/0000-0001-5256-8683, PMID:31932071]
synonym: "enhanced TGF response" EXACT []
synonym: "enhanced tubuloglomerular feedback response" EXACT []
synonym: "improved TGF response" EXACT []
synonym: "improved tubuloglomerular feedback response" EXACT []
synonym: "increased TGF response" EXACT []
is_a: MP:0011295 ! abnormal tubuloglomerular feedback response
property_value: dc:date "2022-05-23T08:32:13Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031405
name: abnormal Sertoli cell proliferation
def: "any anomaly in the ability of a Sertoli cell population to undergo expansion by cell division" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0003830 ! abnormal testis development
property_value: dc:date "2022-06-02T11:39:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031406
name: decreased Sertoli cell proliferation
def: "reduction in the expansion rate of a Sertoli cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced Sertoli cell proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0031405 ! abnormal Sertoli cell proliferation
property_value: dc:date "2022-06-02T11:44:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031407
name: increased Sertoli cell proliferation
def: "increase in the expansion rate of a Sertoli cell population by cell division" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated Sertoli cell proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0031405 ! abnormal Sertoli cell proliferation
property_value: dc:date "2022-06-02T11:47:28Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031408
name: multi-headed sperm
def: "presence of more than one heads per sperm cell" [https://orcid.org/0000-0002-6490-7723, PMID:26472152, PMID:33008835]
synonym: "multiheaded sperm" EXACT []
synonym: "multiple sperm heads" EXACT []
synonym: "polycephalic sperm" EXACT []
synonym: "supernumerary sperm heads" EXACT []
is_a: MP:0009230 ! abnormal sperm head morphology
property_value: dc:date "2022-06-02T12:17:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031409
name: double-headed sperm
def: "presence of two heads per sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "bicephalic sperm" EXACT []
synonym: "dicephalic sperm" EXACT []
synonym: "double headed sperm" EXACT []
synonym: "double sperm heads" EXACT []
synonym: "two sperm heads" EXACT []
synonym: "two-headed sperm" EXACT []
is_a: MP:0031408 ! multi-headed sperm
property_value: dc:date "2022-06-02T12:43:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031410
name: biflagellated sperm
def: "presence of two flagella per sperm cell" [https://orcid.org/0000-0002-6490-7723]
synonym: "bi-flagellate sperm" EXACT []
synonym: "bi-flagellated sperm" EXACT []
synonym: "biflagellate sperm" EXACT []
synonym: "double sperm tails" EXACT []
synonym: "double-tailed sperm" EXACT []
synonym: "duplicate sperm tails" EXACT []
synonym: "two sperm flagella" EXACT []
synonym: "two sperm tails" EXACT []
synonym: "two tailed sperm" EXACT []
synonym: "two-tailed sperm" EXACT []
is_a: MP:0009839 ! multiflagellated sperm
property_value: dc:date "2022-06-02T13:17:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031411
name: increased ovulation rate
def: "increase in the frequency in which an ovum (or ova) is/are released from a rupturing ovarian follicle(s)" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "enhanced ovulation" BROAD []
synonym: "increased ovulation" BROAD []
synonym: "increased ovulation frequency" EXACT []
is_a: MP:0001928 ! abnormal ovulation
property_value: dc:date "2022-06-02T13:48:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031412
name: abnormal muscle triglyceride level
def: "any anomaly in the concentration of naturally occurring esters of three fatty acids and glycerol in muscle tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000187 ! abnormal triglyceride level
is_a: MP:0002108 ! abnormal muscle morphology
property_value: dc:date "2022-06-06T09:30:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031413
name: abnormal skeletal muscle triglyceride level
def: "any anomaly in the concentration of naturally occurring esters of three fatty acids and glycerol in skeletal muscle tissue" [https://orcid.org/0000-0001-5256-8683, https://orcid.org/0000-0002-6490-7723, PMID:11254461]
is_a: MP:0000759 ! abnormal skeletal muscle morphology
is_a: MP:0031412 ! abnormal muscle triglyceride level
property_value: dc:date "2022-06-06T09:40:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031414
name: decreased skeletal muscle triglyceride level
def: "less than the normal concentration of naturally occurring esters of three fatty acids and glycerol in skeletal muscle tissue" [https://orcid.org/0000-0001-5256-8683, https://orcid.org/0000-0002-6490-7723, PMID:11254461]
synonym: "reduced skeletal muscle triglyceride level" EXACT []
is_a: MP:0005318 ! decreased triglyceride level
is_a: MP:0031413 ! abnormal skeletal muscle triglyceride level
property_value: dc:date "2022-06-06T09:51:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031415
name: increased skeletal muscle triglyceride level
def: "greater than the normal concentration of naturally occurring esters of three fatty acids and glycerol in skeletal muscle tissue" [https://orcid.org/0000-0001-5256-8683, https://orcid.org/0000-0002-6490-7723, PMID:11254461]
synonym: "elevated skeletal muscle triglyceride level" EXACT []
is_a: MP:0005317 ! increased triglyceride level
is_a: MP:0031413 ! abnormal skeletal muscle triglyceride level
property_value: dc:date "2022-06-06T09:59:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031416
name: abnormal cardiac muscle triglyceride level
def: "any anomaly in the concentration of naturally occurring esters of three fatty acids and glycerol in heart muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiomyocyte triglyceride level" EXACT []
synonym: "abnormal heart muscle triglyceride level" EXACT []
synonym: "abnormal myocardial triglyceride level" EXACT []
is_a: MP:0010630 ! abnormal cardiac muscle tissue morphology
is_a: MP:0031412 ! abnormal muscle triglyceride level
property_value: dc:date "2022-06-06T10:06:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031417
name: decreased cardiac muscle triglyceride level
def: "less than the normal concentration of naturally occurring esters of three fatty acids and glycerol in heart muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiomyocyte triglyceride level" EXACT []
synonym: "decreased heart muscle triglyceride level" EXACT []
synonym: "decreased myocardial triglyceride level" EXACT []
synonym: "reduced cardiac muscle triglyceride level" EXACT []
synonym: "reduced cardiomyocyte triglyceride level" EXACT []
synonym: "reduced heart muscle triglyceride level" EXACT []
synonym: "reduced myocardial triglyceride level" EXACT []
is_a: MP:0005318 ! decreased triglyceride level
is_a: MP:0031416 ! abnormal cardiac muscle triglyceride level
property_value: dc:date "2022-06-06T10:16:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031418
name: increased cardiac muscle triglyceride level
def: "greater than the normal concentration of naturally occurring esters of three fatty acids and glycerol in heart muscle" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated cardiac muscle triglyceride level" EXACT []
synonym: "increased cardiomyocyte triglyceride level" EXACT []
synonym: "increased heart muscle triglyceride level" EXACT []
synonym: "increased myocardial triglyceride level" EXACT []
is_a: MP:0005317 ! increased triglyceride level
is_a: MP:0031416 ! abnormal cardiac muscle triglyceride level
property_value: dc:date "2022-06-06T10:23:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031419
name: delayed estrus
def: "increase in the time between the estrus phases of the estrous cycle in females" [https://orcid.org/0000-0002-6490-7723, https://orcid.org/0000-0003-4606-0597]
synonym: "delayed estrous" EXACT []
synonym: "delayed estrous phase" EXACT []
synonym: "delayed estrus phase" EXACT []
synonym: "delayed oestrous" EXACT []
synonym: "delayed oestrous phase" EXACT []
is_a: MP:0009016 ! abnormal estrus
property_value: dc:date "2022-06-06T13:47:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031420
name: decreased superovulation rate
def: "decreased ability of a female to be induced to ovulate resulting in fewer than the expected number of ova after treatment with specific gonadotrophic hormones" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased superovulation" BROAD []
synonym: "decreased superovulation frequency" EXACT []
synonym: "reduced superovulation" BROAD []
synonym: "reduced superovulation frequency" EXACT []
synonym: "reduced superovulation rate" EXACT []
is_a: MP:0003355 ! decreased ovulation rate
is_a: MP:0009648 ! abnormal superovulation
property_value: dc:date "2022-06-06T17:57:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031421
name: increased superovulation rate
def: "increased ability of a female to be induced to ovulate resulting in greater than the expected number of ova after treatment with specific gonadotrophic hormones" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced superovulation" BROAD []
synonym: "increased superovulation" BROAD []
synonym: "increased superovulation frequency" EXACT []
is_a: MP:0009648 ! abnormal superovulation
is_a: MP:0031411 ! increased ovulation rate
property_value: dc:date "2022-06-06T18:02:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031422
name: failure of superovulation
def: "inability of a female to be induced to ovulate after treatment with specific gonadotrophic hormones" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0008869 ! anovulation
is_a: MP:0009648 ! abnormal superovulation
property_value: dc:date "2022-06-06T18:07:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031423
name: abnormal luteolysis
def: "any anomaly in the structural and functional degradation of the corpus luteum occurring at the end of the luteal phase of both the estrous and menstrual cycles in the absence of pregnancy; during normal luteolysis, loss of the capacity to synthesize and secrete progesterone (functional luteolysis) is followed by loss of the cells that comprise the corpus luteum (structural luteolysis)" [GO:0001554, https://en.wiktionary.org/wiki/luteolysis]
comment: The regression of the corpus luteum is essential to reset the ovarian cycle, so that mammals obtain another chance to become pregnant. {xref="PMID:24586455"}
synonym: "abnormal CL regression" EXACT []
synonym: "abnormal corpus luteum regression" EXACT []
synonym: "abnormal luteal regression" EXACT []
is_a: MP:0009344 ! abnormal ovulation cycle
property_value: dc:date "2022-06-20T12:43:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031424
name: enhanced female fertility
def: "increased physiological ability of a female organism to produce live offspring" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased female fertility" EXACT []
is_a: MP:0010143 ! enhanced fertility
property_value: dc:date "2022-06-20T13:24:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031425
name: enhanced male fertility
def: "increased physiological ability of a male organism to produce live offspring" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased male fertility" EXACT []
is_a: MP:0010143 ! enhanced fertility
property_value: dc:date "2022-06-20T13:29:01Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031426
name: increased sperm motility
def: "increased mobility of the spermatozoa" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced sperm motility" EXACT []
is_a: MP:0002674 ! abnormal sperm motility
property_value: dc:date "2022-06-27T06:50:15Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031427
name: increased sperm progressive motility
def: "increase in the ability of sperm to move in a more or less straight line" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced sperm progressive motility" EXACT []
is_a: MP:0020450 ! abnormal sperm progressive motility
is_a: MP:0031426 ! increased sperm motility
property_value: dc:date "2022-06-27T07:27:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031428
name: lens dislocation
def: "partial or complete displacement of the crystalline lens of the eye out of its normal position" [https://orcid.org/0000-0002-6490-7723]
comment: A partial displacement (or dislocation) of the lens is described as lens subluxation, while a complete displacement is termed lens luxation.
synonym: "dislocated lens" EXACT []
synonym: "dislocated lenses" EXACT []
synonym: "ectopia lentis" EXACT []
synonym: "lens displacement" EXACT []
is_a: MP:0020486 ! abnormal lens topology
property_value: dc:date "2022-06-27T08:37:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031429
name: lens luxation
def: "complete displacement of the crystalline lens of the eye out of its normal position" [https://orcid.org/0000-0002-6490-7723]
comment: The lens is defined as luxated (dislocated) when it lies completely outside of the hyaloid fossa, is free-floating in the vitreous, is in the anterior chamber, or lies directly on the retina. {xref="https://eyewiki.aao.org/Ectopia_Lentis"}
synonym: "complete lens dislocation" EXACT []
synonym: "complete lens displacement" EXACT []
synonym: "fully luxated lens" EXACT []
synonym: "fully luxated lenses" EXACT []
is_a: MP:0031428 ! lens dislocation
property_value: dc:date "2022-06-27T10:39:13Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031430
name: lens subluxation
def: "partial displacement of the crystalline lens of the eye out of its normal position" [https://orcid.org/0000-0002-6490-7723]
comment: The lens is considered subluxated when it is partially displaced but remains within the lens space. {xref="https://eyewiki.aao.org/Ectopia_Lentis"}
synonym: "partial lens dislocation" EXACT []
synonym: "partial lens displacement" EXACT []
synonym: "partially dislocated lens" EXACT []
synonym: "partially dislocated lenses" EXACT []
synonym: "subluxated lens" EXACT []
synonym: "subluxated lenses" EXACT []
is_a: MP:0031428 ! lens dislocation
property_value: dc:date "2022-06-27T11:08:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031431
name: increased spongiotrophoblast cell number
def: "increase in the number of trophoblast cells that arise in the junctional zone of the placenta" [https://orcid.org/0000-0002-6490-7723]
synonym: "higher spongiotrophoblast cell number" EXACT []
is_a: MP:0008959 ! abnormal spongiotrophoblast cell morphology
property_value: dc:date "2022-06-27T11:59:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031432
name: cornea perforation
def: "a puncture or hole through the cornea stroma resulting from various diseases or trauma" [https://meshb-prev.nlm.nih.gov/record/ui?ui=D057112]
synonym: "corneal perforation" EXACT []
synonym: "corneal perforations" EXACT []
synonym: "perforated cornea" EXACT []
synonym: "perforated corneas" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
property_value: dc:date "2022-06-27T14:10:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031433
name: decreased miscarriage rate
def: "decrease in the frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased spontaneous abortion rate" EXACT []
synonym: "reduced miscarriage rate" EXACT []
synonym: "reduced spontaneous abortion rate" EXACT []
is_a: MP:0004244 ! abnormal miscarriage rate
property_value: dc:date "2022-07-11T16:47:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031434
name: increased miscarriage rate
def: "increase in the frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated miscarriage rate" EXACT []
synonym: "increased spontaneous abortion rate" EXACT []
synonym: "miscarriage" BROAD []
is_a: MP:0004244 ! abnormal miscarriage rate
property_value: dc:date "2022-07-11T16:52:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031435
name: abnormal copulatory plug biosynthesis
def: "any anomaly in the reactions and pathways involved in the formation of a copulatory plug; typically, plugs are formed by coagulation of ejaculated proteins to form a solid mass within the female reproductive tract" [PMID:33077605]
comment: This term should be used when there is a physiological anomaly in the ability to create a copulatory plug but mating behavior is normal
synonym: "abnormal mating plug biosynthesis" EXACT []
synonym: "abnormal vaginal plug biosynthesis" EXACT []
is_a: MP:0031627 ! abnormal copulation physiology
property_value: dc:date "2022-07-11T17:47:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031436
name: decreased copulatory plug deposition
def: "decrease in the number of copulatory plugs deposited in a study population of females by a male(s) at the termination of copulation" [https://orcid.org/0000-0003-3645-6803]
synonym: "decreased copulatory plug formation" BROAD []
synonym: "decreased mating plug deposition" EXACT []
synonym: "decreased mating plug formation" BROAD []
synonym: "decreased vaginal plug deposition" EXACT []
synonym: "decreased vaginal plug formation" BROAD []
synonym: "reduced copulatory plug deposition" EXACT []
synonym: "reduced mating plug deposition" EXACT []
synonym: "reduced vaginal plug deposition" EXACT []
is_a: MP:0030982 ! abnormal copulatory plug deposition
property_value: dc:date "2022-07-11T18:49:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031437
name: increased copulatory plug deposition
def: "increase in the number of copulatory plugs deposited in a study population of females by a male(s) at the termination of copulation" [https://orcid.org/0000-0003-3645-6803]
synonym: "increased copulatory plug formation" BROAD []
synonym: "increased mating plug deposition" EXACT []
synonym: "increased mating plug formation" BROAD []
synonym: "increased vaginal plug deposition" EXACT []
synonym: "increased vaginal plug formation" BROAD []
is_a: MP:0030982 ! abnormal copulatory plug deposition
property_value: dc:date "2022-07-11T18:54:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031438
name: abnormal sperm radial spoke morphology
def: "any structural anomaly of the T-shaped protein complex that links an outer microtubule doublet of the sperm flagellum axoneme with the sheath that surrounds the central pair of microtubules; it is composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules" [GO:0001534, PMID:34871179]
is_a: MP:0009838 ! abnormal sperm axoneme morphology
property_value: dc:date "2022-08-01T10:17:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031439
name: small lymphatic vessel
def: "decreased size of the lymphatic vessels which form a network that carries lymph around the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lymphatic vessel size" EXACT []
synonym: "reduced lymphatic vessel size" EXACT []
synonym: "small lymphatic vessels" EXACT []
is_a: MP:0001879 ! abnormal lymphatic vessel morphology
property_value: dc:date "2022-08-02T08:05:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031440
name: lymphatic vessel hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the lymphatic vessels, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic lymphatic vessel" EXACT []
synonym: "hypoplastic lymphatic vessels" EXACT []
is_a: MP:0031439 ! small lymphatic vessel
property_value: dc:date "2022-08-02T08:12:30Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031441
name: increased periocular mesenchyme apoptosis
def: "increase in the number of cells of the periocular mesenchyme undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0030325 ! abnormal periocular mesenchyme apoptosis
property_value: dc:date "2022-09-26T06:37:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031442
name: enlarged cerebral aqueduct
def: "increased size of the channel in the mesencephalon that connects the third and fourth ventricles" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged aqueduct of midbrain" EXACT []
synonym: "enlarged aqueduct of Sylvius" EXACT []
synonym: "enlarged cerebral aqueduct of Sylvius" EXACT []
synonym: "enlarged mesencephalic duct" EXACT []
synonym: "enlarged mesencephalic vesicle" EXACT []
synonym: "enlarged midbrain cerebral aqueduct" EXACT []
synonym: "expanded cerebral aqueduct" EXACT []
synonym: "expanded midbrain cerebral aqueduct" EXACT []
is_a: MP:0005537 ! abnormal cerebral aqueduct morphology
property_value: dc:date "2022-10-10T09:56:13Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031443
name: abnormal tongue position
def: "atypical location or placement of the tongue in the oral cavity" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lingual location" EXACT []
synonym: "abnormal lingual placement" EXACT []
synonym: "abnormal lingual position" EXACT []
synonym: "abnormal tongue location" EXACT []
synonym: "abnormal tongue placement" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: dc:date "2022-10-10T16:00:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031444
name: glossoptosis
def: "downward or posterior displacement of the tongue toward the pharynx" [HP:0000162, https://en.wikipedia.org/wiki/Glossoptosis]
synonym: "lingual retraction" EXACT []
synonym: "posterior displacement of the tongue" EXACT []
synonym: "retraction of the tongue" EXACT []
is_a: MP:0031443 ! abnormal tongue position
property_value: dc:date "2022-10-10T16:18:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031445
name: midline cleft upper lip
def: "a vertical cleft through the center of the upper lip" [PMID:27218021]
synonym: "central cleft upper lip" EXACT []
synonym: "median cleft lip" BROAD []
synonym: "median cleft upper lip" EXACT []
synonym: "median upper lip notch" NARROW []
synonym: "midline cleft lip" BROAD []
is_a: MP:0005170 ! cleft upper lip
property_value: dc:date "2022-10-10T16:51:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031446
name: non-midline cleft upper lip
def: "a cleft of the upper lip affecting the lateral portions rather than the center (midline/median region) of the upper lip" [HP:0100335, https://orcid.org/0000-0002-6490-7723]
synonym: "non-midline cleft lip" BROAD []
synonym: "non-midline cleft of the upper lip" EXACT []
synonym: "paramedian cleft lip" BROAD []
synonym: "paramedian cleft of the upper lip" EXACT []
synonym: "paramedian cleft upper lip" EXACT []
is_a: MP:0005170 ! cleft upper lip
property_value: dc:date "2022-10-10T16:56:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031447
name: unilateral cleft upper lip
def: "a non-midline cleft occurring on only one side of the upper lip" [HP:0100333, https://orcid.org/0000-0002-6490-7723]
synonym: "one sided cleft upper lip" EXACT []
synonym: "one-sided cleft upper lip" EXACT []
synonym: "unilateral cheiloschisis" EXACT []
synonym: "unilateral cleft lip" BROAD []
is_a: MP:0031446 ! non-midline cleft upper lip
property_value: dc:date "2022-10-10T17:05:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031448
name: bilateral cleft upper lip
def: "a non-midline cleft occurring on both sides of the upper lip" [HP:0100336, https://orcid.org/0000-0002-6490-7723]
synonym: "bilateral cheiloschisis" EXACT []
synonym: "bilateral cleft lip" BROAD []
is_a: MP:0031446 ! non-midline cleft upper lip
property_value: dc:date "2022-10-10T17:18:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031449
name: abnormal nasal cartilage morphology
def: "any structural abnormality of any of the cartilaginous elements formed from hyaline cartilage that provide form and support to the nose" [https://en.wikipedia.org/wiki/Nasal_cartilages, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002233 ! abnormal nose morphology
is_a: MP:0006429 ! abnormal hyaline cartilage morphology
property_value: dc:date "2022-10-17T07:36:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031450
name: nasal cartilage hypoplasia
def: "decrease in the number of normal cells in normal arrangement in any of the hyaline cartilaginous components of the nose, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic nasal cartilage" EXACT []
synonym: "hypoplastic nasal cartilages" EXACT []
is_a: MP:0031449 ! abnormal nasal cartilage morphology
property_value: dc:date "2022-10-17T08:35:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031451
name: abnormal median sulcus of tongue morphology
def: "any structural anomaly of the slight longitudinal depression on the dorsal surface of the tongue which extends from the tip of the tongue to the foramen cecum and divides the dorsum into right and left halves" [https://medical-dictionary.thefreedictionary.com/median+sulcus+of+tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Median-sulcus-of-tongue]
synonym: "abnormal median groove of tongue morphology" EXACT []
synonym: "abnormal median longitudinal raphe of tongue morphology" EXACT []
is_a: MP:0000762 ! abnormal tongue morphology
property_value: dc:date "2022-10-17T10:17:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031452
name: decreased neural crest cell apoptosis
def: "decreased number of any population of neural crest cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased NCC apoptosis" EXACT []
synonym: "reduced NCC apoptosis" EXACT []
synonym: "reduced neural crest cell apoptosis" EXACT []
is_a: MP:0009844 ! abnormal neural crest cell apoptosis
is_a: MP:0013505 ! decreased embryonic tissue cell apoptosis
property_value: dc:date "2022-10-17T11:21:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031453
name: decreased cardiac neural crest cell apoptosis
def: "decreased number of cardiac neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiac NCC apoptosis" EXACT []
synonym: "reduced cardiac NCC apoptosis" EXACT []
synonym: "reduced cardiac neural crest cell apoptosis" EXACT []
is_a: MP:0031452 ! decreased neural crest cell apoptosis
property_value: dc:date "2022-10-17T11:35:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031454
name: decreased cranial neural crest cell apoptosis
def: "decreased number of cranial neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cephalic NCC apoptosis" EXACT []
synonym: "decreased cephalic neural crest cell apoptosis" EXACT []
synonym: "decreased cranial NCC apoptosis" EXACT []
synonym: "decreased head NCC apoptosis" EXACT []
synonym: "decreased head neural crest cell apoptosis" EXACT []
synonym: "reduced cephalic NCC apoptosis" EXACT []
synonym: "reduced cephalic neural crest cell apoptosis" EXACT []
synonym: "reduced cranial NCC apoptosis" EXACT []
synonym: "reduced cranial neural crest cell apoptosis" EXACT []
synonym: "reduced head NCC apoptosis" EXACT []
synonym: "reduced head neural crest cell apoptosis" EXACT []
is_a: MP:0031452 ! decreased neural crest cell apoptosis
property_value: dc:date "2022-10-17T11:41:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031455
name: decreased trunk neural crest cell apoptosis
def: "decreased number of trunk neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased trunk NCC apoptosis" EXACT []
synonym: "reduced trunk NCC apoptosis" EXACT []
synonym: "reduced trunk neural crest cell apoptosis" EXACT []
is_a: MP:0031452 ! decreased neural crest cell apoptosis
property_value: dc:date "2022-10-17T11:53:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031456
name: decreased vagal neural crest cell apoptosis
def: "decreased number of vagal neural crest cells (NCCs) undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased vagal NCC apoptosis" EXACT []
synonym: "reduced vagal NCC apoptosis" EXACT []
synonym: "reduced vagal neural crest cell apoptosis" EXACT []
is_a: MP:0031452 ! decreased neural crest cell apoptosis
property_value: dc:date "2022-10-17T11:58:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031457
name: abnormal vomeronasal cartilage morphology
def: "any structural anomaly of the narrow process of cartilage found between the vomer and the cartilage of the nasal septum; it lies below, but is not connected to, the rudimentary vomeronasal organ" [https://en.wikipedia.org/wiki/Vomeronasal_cartilage, https://orcid.org/0000-0002-6490-7723, https://www.merriam-webster.com/medical/vomeronasal%20cartilage]
synonym: "abnormal Huschke's cartilage morphology" EXACT []
synonym: "abnormal Jacobson's cartilage morphology" EXACT []
is_a: MP:0031449 ! abnormal nasal cartilage morphology
property_value: dc:date "2022-10-24T07:10:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031458
name: absent palate bones
def: "absence of both the maxillary and palatine shelves that comprise the bones of the hard palate" [https://orcid.org/0000-0002-6490-7723]
synonym: "absent palatal bones" EXACT []
is_a: MP:0009891 ! abnormal palate bone morphology
property_value: dc:date "2022-10-24T08:56:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031459
name: maxillary zygomatic process hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the maxillary zygomatic process, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic malar process" EXACT []
synonym: "hypoplastic maxilla zygomatic process" EXACT []
synonym: "hypoplastic maxillary zygomatic process" EXACT []
synonym: "hypoplastic zygomatic process of the maxilla" EXACT []
synonym: "malar process hypoplasia" EXACT []
is_a: MP:0030302 ! abnormal maxillary zygomatic process morphology
property_value: dc:date "2022-11-14T09:40:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031460
name: abnormal palatal shelf morphology
def: "any structural anomaly of either one of the paired outgrowths arising from the oral surface of the embryonic maxillary processes that come together during prenatal development to form the secondary palate" [https://orcid.org/0000-0002-6490-7723, PMID:22186724, UBERON:0005619]
synonym: "abnormal lateral palatine process morphology" EXACT []
synonym: "abnormal secondary palatal shelf morphology" EXACT []
is_a: MP:0009655 ! abnormal secondary palate development
property_value: dc:date "2022-11-14T14:56:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031461
name: abnormal palatal shelf size
def: "anomaly in the size of either one or both of the palatal shelves compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lateral palatine process size" EXACT []
synonym: "abnormal secondary palatal shelf size" EXACT []
is_a: MP:0031460 ! abnormal palatal shelf morphology
property_value: dc:date "2022-11-14T15:24:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031462
name: decreased palatal shelf size
def: "reduced size of either one or both of the palatal shelves compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased lateral palatine process size" EXACT []
synonym: "decreased secondary palatal shelf size" EXACT []
synonym: "reduced lateral palatine process size" EXACT []
synonym: "reduced palatal shelf size" EXACT []
synonym: "reduced secondary palatal shelf size" EXACT []
synonym: "small lateral palatine process" EXACT []
synonym: "small palatal shelf" EXACT []
synonym: "small secondary palatal shelf" EXACT []
is_a: MP:0031461 ! abnormal palatal shelf size
property_value: dc:date "2022-11-14T15:31:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031463
name: increased palatal shelf size
def: "increased size of either one or both of the palatal shelves compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged lateral palatine process" EXACT []
synonym: "enlarged palatal shelf" EXACT []
synonym: "enlarged secondary palatal shelf" EXACT []
synonym: "increased lateral palatine process size" EXACT []
synonym: "increased secondary palatal shelf size" EXACT []
is_a: MP:0031461 ! abnormal palatal shelf size
property_value: dc:date "2022-11-14T15:37:55Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031464
name: abnormal spontaneous fetal mouth movement
def: "any anomaly in the spontaneous neuromuscular movements of the mandible and tongue prior to birth" [https://orcid.org/0000-0002-6490-7723, PMID:31300413]
comment: Spontaneous fetal mouth movements play a role in proper development of the palate.
synonym: "abnormal spontaneous foetal mouth movement" EXACT []
is_a: MP:0001388 ! abnormal stationary movement
is_a: MP:0031494 ! abnormal prenatal movement
property_value: dc:date "2023-02-08T08:03:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031466
name: abnormal palatal taste bud morphology
def: "any structural anomaly of the taste bud, a specialized receptor organ consisting of a group of clustered sensory cells, located on the soft palate, in the roof of the mouth; palatal taste buds lack supporting papilla structures and are directly embedded in the epithelium of the soft palate" [PMID:25299669, UBERON:0034670]
is_a: MP:0003154 ! abnormal soft palate morphology
is_a: MP:0031468 ! abnormal taste bud morphology
property_value: dc:date "2023-05-08T10:09:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031467
name: absent palatal taste bud
def: "absence of the palatal taste buds that normally develop in the epithelium of the soft palate without associated papilla structures" [PMID:17015430, PMID:25299669]
synonym: "absent palatal taste buds" EXACT []
is_a: MP:0031466 ! abnormal palatal taste bud morphology
property_value: dc:date "2023-05-08T10:39:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031468
name: abnormal taste bud morphology
def: "any structural anomaly of the specialized receptor organ that is a collection of cells spanning the gustatory epithelium" [UBERON:0001727]
comment: In humans, lingual taste buds are found exclusively within gustatory papillae of the tongue, including the circumvallate, foliate, and fungiform papillae. Extra-lingual taste buds are smoothly embedded in the surface mucosa without papillae, e.g., buds of the soft palate, oropharynx, larynx (epiglottis), and the upper esophagus. {xref="PMID:31604544", xref="https://www.kenhub.com/en/library/anatomy/taste-buds"}
synonym: "abnormal taste buds" BROAD []
synonym: "taste bud dysplasia" NARROW []
is_a: MP:0005500 ! abnormal gustatory system morphology
property_value: dc:date "2023-05-15T18:41:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031469
name: abnormal pinocytosis
def: "any anomaly in the endocytosis process that results in the uptake of liquid material by cells from their external environment; liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane" [GO:0006907, https://www.biologyonline.com/dictionary/pinocytosis]
synonym: "abnormal cell drinking" EXACT []
synonym: "abnormal cellular drinking" EXACT []
synonym: "abnormal fluid-phase endocytosis" EXACT []
is_a: MP:0030951 ! abnormal endocytosis
property_value: dc:date "2023-05-22T10:18:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031470
name: abnormal macropinocytosis
def: "any anomaly in the endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size" [GO:0044351, https://www.biologyonline.com/dictionary/pinocytosis]
is_a: MP:0031469 ! abnormal pinocytosis
property_value: dc:date "2023-05-22T10:23:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031471
name: abnormal micropinocytosis
def: "any anomaly in the endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm" [GO:0044350, https://www.biologyonline.com/dictionary/pinocytosis]
is_a: MP:0031469 ! abnormal pinocytosis
property_value: dc:date "2023-05-22T10:27:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031472
name: abnormal female germ cell apoptosis
def: "change in the timing or the number of female germ cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal oocyte apoptosis" NARROW []
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0020364 ! abnormal female germ cell physiology
property_value: dc:date "2023-05-22T11:40:31Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031473
name: decreased female germ cell apoptosis
def: "decrease in the number of female germ cells undergoing programmed cell death" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "decreased oocyte apoptosis" NARROW []
synonym: "reduced female germ cell apoptosis" EXACT []
synonym: "reduced oocyte apoptosis" NARROW []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0031472 ! abnormal female germ cell apoptosis
property_value: dc:date "2023-05-22T11:45:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031474
name: increased female germ cell apoptosis
def: "increase in the number of female germ cells undergoing programmed cell death" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "elevated female germ cell apoptosis" EXACT []
synonym: "elevated oocyte apoptosis" NARROW []
synonym: "increased oocyte apoptosis" NARROW []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0031472 ! abnormal female germ cell apoptosis
property_value: dc:date "2023-05-22T11:51:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031475
name: decreased male germ cell apoptosis
def: "decrease in the number of male germ cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced male germ cell apoptosis" EXACT []
is_a: MP:0008280 ! abnormal male germ cell apoptosis
property_value: dc:date "2023-05-22T16:40:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031476
name: decreased ovary apoptosis
def: "decrease in the number of ovary cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ovarian apoptosis" EXACT []
synonym: "reduced ovarian apoptosis" EXACT []
synonym: "reduced ovary apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0013506 ! abnormal ovary apoptosis
property_value: dc:date "2023-05-22T16:52:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031477
name: vein stenosis
def: "abnormal narrowing or constriction of one or more veins" [https://orcid.org/0000-0002-6490-7723]
synonym: "venous stenosis" EXACT []
is_a: MP:0002725 ! abnormal vein morphology
is_a: MP:0005412 ! vascular stenosis

[Term]
id: MP:0031478
name: Brunner’s gland hyperplasia
def: "increase in the number of normal cells in normal arrangement in Brunner’s gland, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "duodenal gland hyperplasia" EXACT []
synonym: "hyperplasia of Brunner’s gland" EXACT []
synonym: "hyperplastic Brunner’s gland" EXACT []
synonym: "hyperplastic Brunner’s glands" EXACT []
synonym: "hyperplastic duodenal gland" EXACT []
synonym: "hyperplastic duodenal glands" EXACT []
is_a: MP:0012518 ! abnormal Brunner's gland morphology

[Term]
id: MP:0031479
name: increased urine xanthine level
def: "excretion of excessive amounts of xanthine in the urine; xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids" [CHEBI:15318, GO:0046111, https://emedicine.medscape.com/article/984002-overview]
synonym: "hyperxanthinuria" EXACT []
synonym: "increased urinary xanthine level" EXACT []
synonym: "xanthinuria" EXACT []
is_a: MP:0031480 ! abnormal urine xanthine level
property_value: dc:date "2023-07-06T09:32:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031480
name: abnormal urine xanthine level
def: "any anomaly in the amount in the urine of xanthine (2,6-dihydroxypurine), a purine that is formed in the metabolic breakdown of guanine but is not present in nucleic acids" [CHEBI:15318, GO:0046111, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urinary xanthine level" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: dc:date "2023-07-06T10:02:48Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031481
name: decreased urine xanthine level
def: "a reduced amount of xanthine in the urine compared to the normal state" [CHEBI:15318, GO:0046111, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urinary xanthine level" EXACT []
synonym: "reduced urine xanthine level" EXACT []
is_a: MP:0031480 ! abnormal urine xanthine level
property_value: dc:date "2023-07-06T10:08:58Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031482
name: abnormal urine hypoxanthine level
def: "any anomaly in the amount in the urine of hypoxanthine (6-hydroxy purine), an intermediate in the degradation of adenylate" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal urinary hypoxanthine level" EXACT []
is_a: MP:0009643 ! abnormal urine homeostasis
property_value: dc:date "2023-07-06T10:46:36Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031483
name: decreased urine hypoxanthine level
def: "a reduced amount of hypoxanthine in the urine compared to the normal state" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased urinary hypoxanthine level" EXACT []
synonym: "reduced urine hypoxanthine level" EXACT []
is_a: MP:0031482 ! abnormal urine hypoxanthine level
property_value: dc:date "2023-07-06T10:52:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031484
name: increased urine hypoxanthine level
def: "an increased amount of hypoxanthine in the urine compared to the normal state" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "hypoxanthinuria" EXACT []
synonym: "increased urinary hypoxanthine level" EXACT []
is_a: MP:0031482 ! abnormal urine hypoxanthine level
property_value: dc:date "2023-07-06T10:56:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031485
name: abnormal circulating hypoxanthine level
def: "any anomaly in the amount in the blood of hypoxanthine (6-hydroxy purine), an intermediate in the degradation of adenylate" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal blood hypoxanthine level" EXACT []
synonym: "abnormal serum hypoxanthine level" NARROW []
is_a: MP:0009642 ! abnormal blood homeostasis
property_value: dc:date "2023-07-06T11:23:39Z" xsd:dateTime

[Term]
id: MP:0031486
name: decreased circulating hypoxanthine level
def: "a reduced amount of hypoxanthine in the blood compared to the normal state" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased blood hypoxanthine level" EXACT []
synonym: "decreased serum hypoxanthine level" NARROW []
synonym: "reduced circulating hypoxanthine level" EXACT []
synonym: "reduced serum hypoxanthine level" NARROW []
is_a: MP:0031485 ! abnormal circulating hypoxanthine level
property_value: dc:date "2023-07-06T11:28:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031487
name: increased circulating hypoxanthine level
def: "an increased amount of hypoxanthine in the blood compared to the normal state" [CHEBI:17368, GO:0046101, https://orcid.org/0000-0002-6490-7723]
synonym: "increased blood hypoxanthine level" EXACT []
synonym: "increased serum hypoxanthine level" NARROW []
is_a: MP:0031485 ! abnormal circulating hypoxanthine level
property_value: dc:date "2023-07-06T11:36:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031488
name: abnormal circulating xanthine level
def: "any anomaly in the amount in the blood of xanthine (2,6-dihydroxypurine), a purine that is formed in the metabolic breakdown of guanine but is not present in nucleic acids" [CHEBI:15318, GO:0046111, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal blood xanthine level" EXACT []
synonym: "abnormal serum xanthine level" NARROW []
is_a: MP:0009642 ! abnormal blood homeostasis
property_value: dc:date "2023-07-06T12:11:34Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031489
name: decreased circulating xanthine level
def: "a reduced amount of xanthine in the blood compared to the normal state" [CHEBI:15318, GO:0046111, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased blood xanthine level" EXACT []
synonym: "decreased serum xanthine level" NARROW []
synonym: "reduced circulating xanthine level" EXACT []
synonym: "reduced serum xanthine level" NARROW []
is_a: MP:0031488 ! abnormal circulating xanthine level
property_value: dc:date "2023-07-06T12:17:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031490
name: increased circulating xanthine level
def: "an increased amount of xanthine in the blood compared to the normal state" [CHEBI:15318, GO:0046111, https://orcid.org/0000-0002-6490-7723]
synonym: "hyperxanthinaemia" EXACT []
synonym: "hyperxanthinemia" EXACT []
synonym: "increased blood xanthine level" EXACT []
synonym: "increased serum xanthine level" NARROW []
is_a: MP:0031488 ! abnormal circulating xanthine level
property_value: dc:date "2023-07-06T12:22:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031491
name: decreased oval window size
def: "less than average size of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "decreased fenestra ovalis size" EXACT []
synonym: "decreased vestibular window size" EXACT []
synonym: "reduced oval window size" EXACT []
synonym: "reduced vestibular window size" EXACT []
synonym: "small fenestra ovalis" EXACT []
synonym: "small fenestra vestibuli" EXACT []
synonym: "small oval window" EXACT []
synonym: "small vestibular window" EXACT []
is_a: MP:0004479 ! abnormal oval window morphology
property_value: dc:date "2023-07-17T12:29:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031492
name: increased oval window size
def: "greater than average size of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "enlarged fenestra vestibuli" EXACT []
synonym: "enlarged oval window" EXACT []
synonym: "enlarged vestibular window" EXACT []
synonym: "increased fenestra ovalis size" EXACT []
synonym: "increased vestibular window size" EXACT []
synonym: "large fenestra vestibuli" EXACT []
synonym: "large oval window" EXACT []
synonym: "large vestibular window" EXACT []
is_a: MP:0004479 ! abnormal oval window morphology
property_value: dc:date "2023-07-17T12:37:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031493
name: increased round window size
def: "greater than average size of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [https://orcid.org/0000-0002-6490-7723, ISBN:0-683-40008-8]
synonym: "enlarged cochlear window" EXACT []
synonym: "enlarged fenestra cochleae" EXACT []
synonym: "enlarged fenestra rotunda" EXACT []
synonym: "enlarged round window" EXACT []
synonym: "increased cochlear window size" EXACT []
synonym: "increased fenestra cochleae size" EXACT []
synonym: "increased fenestra rotunda size" EXACT []
synonym: "large cochlear window" EXACT []
synonym: "large fenestra cochleae" EXACT []
synonym: "large fenestra rotunda" EXACT []
synonym: "large round window" EXACT []
is_a: MP:0004480 ! abnormal round window morphology
property_value: dc:date "2023-07-17T12:49:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031494
name: abnormal prenatal movement
def: "any anomaly in the movements of a developing organism within the uterus" [https://en.wikipedia.org/wiki/Fetal_movement, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal fetal movement" NARROW []
synonym: "abnormal foetal movement" NARROW []
is_a: MP:0002066 ! abnormal motor capabilities/coordination/movement
property_value: dc:date "2023-07-17T16:19:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031495
name: absent prenatal movement
def: "absence of any movements of a developing organism within the uterus" [https://en.wikipedia.org/wiki/Fetal_movement, https://orcid.org/0000-0002-6490-7723]
synonym: "absent fetal movement" NARROW []
synonym: "absent foetal movement" NARROW []
is_a: MP:0031494 ! abnormal prenatal movement
property_value: dc:date "2023-07-17T16:31:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031496
name: motor developmental delay
def: "acquisition of motor skills or milestones, including gross and/or fine motor abilities, occurs later in development compared to controls" [HP:0001270, https://orcid.org/0000-0002-6490-7723]
synonym: "delay in motor development" EXACT []
synonym: "delayed development of motor milestones" EXACT []
synonym: "delayed early motor milestones" NARROW []
synonym: "delayed motor development" EXACT []
synonym: "delayed motor milestones" EXACT []
synonym: "locomotor delay" BROAD []
synonym: "motor retardation" BROAD []
synonym: "retarded motor development" EXACT []
is_a: MP:0021165 ! behavioral developmental delay
property_value: dc:date "2023-07-20T08:06:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031497
name: increased visual acuity
def: "gain in visual acuity or increased ability to distinguish small details" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011832 ! abnormal visual acuity
property_value: dc:date "2023-07-20T08:42:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031498
name: abnormal cornea size
def: "deviation from the average range of cornea size for a given organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal corneal size" EXACT []
is_a: MP:0001312 ! abnormal cornea morphology
property_value: dc:date "2023-07-20T10:12:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031499
name: decreased cornea size
def: "reduced average size of one or both corneas; generally refers to a congenital defect" [HP:0000482, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased corneal size" EXACT []
synonym: "microcornea" EXACT []
synonym: "reduced cornea size" EXACT []
synonym: "reduced corneal size" EXACT []
synonym: "small cornea" EXACT []
synonym: "small corneas" EXACT []
is_a: MP:0031498 ! abnormal cornea size
property_value: dc:date "2023-07-20T10:18:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031500
name: increased cornea size
def: "increased average size of one or both corneas" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged cornea" EXACT []
synonym: "enlarged corneas" EXACT []
synonym: "increased corneal size" EXACT []
synonym: "large cornea" EXACT []
synonym: "large corneas" EXACT []
synonym: "macrocornea" EXACT []
synonym: "megalocornea" EXACT []
is_a: MP:0031498 ! abnormal cornea size
property_value: dc:date "2023-07-20T10:25:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031501
name: abnormal mouth shape
def: "any anomaly in the characteristic surface outline or contour of the mouth of an organism" [https://orcid.org/0000-0002-6490-7723]
synonym: "mouth shape abnormalities" EXACT []
is_a: MP:0000452 ! abnormal mouth morphology
property_value: dc:date "2023-07-24T16:09:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031502
name: open mouth
def: "abnormal presence of a permanently or nearly permanently opened mouth" [HP:0000194, https://orcid.org/0000-0002-6490-7723]
synonym: "gaping mouth" EXACT []
is_a: MP:0031501 ! abnormal mouth shape
property_value: dc:date "2023-07-24T16:19:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031503
name: abnormal mouth size
def: "anomaly in the size of the mouth compared to controls" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0000452 ! abnormal mouth morphology
property_value: dc:date "2023-07-24T16:27:21Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031504
name: increased mouth width
def: "increased side-to-side or lateral distance of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "broad mouth" EXACT []
synonym: "wide mouth" EXACT []
is_a: MP:0009881 ! increased mouth size
property_value: dc:date "2023-07-24T16:41:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031505
name: decreased mouth width
def: "decreased side-to-side or lateral distance of the mouth" [https://orcid.org/0000-0002-6490-7723]
synonym: "narrow mouth" EXACT []
synonym: "reduced mouth width" EXACT []
is_a: MP:0009880 ! decreased mouth size
property_value: dc:date "2023-07-24T16:48:07Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031506
name: impaired peripheral nervous system regeneration
def: "decrease in the renewal, repair, and/or regrowth of peripheral nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased peripheral nervous system regeneration" EXACT []
synonym: "decreased PNS regeneration" EXACT []
synonym: "impaired PNS regeneration" EXACT []
synonym: "reduced peripheral nervous system regeneration" EXACT []
synonym: "reduced PNS regeneration" EXACT []
is_a: MP:0004220 ! abnormal peripheral nervous system regeneration
property_value: dc:date "2023-09-19T07:29:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031507
name: enhanced peripheral nervous system regeneration
def: "increase in the renewal, repair, and/or regrowth of peripheral nervous system tissue following injury or disease" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced PNS regeneration" EXACT []
synonym: "improved peripheral nervous system regeneration" EXACT []
synonym: "improved PNS regeneration" EXACT []
synonym: "increased  PNS regeneration" EXACT []
synonym: "increased peripheral nervous system regeneration" EXACT []
is_a: MP:0004220 ! abnormal peripheral nervous system regeneration
property_value: dc:date "2023-09-19T07:38:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031508
name: abnormal vascular smooth muscle cell proliferation
def: "anomaly in the ability of any smooth muscle cell population associated with the vasculature to undergo expansion by cell division" [GO:1990874, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal VSMC proliferation" EXACT []
is_a: MP:0000350 ! abnormal cell proliferation
is_a: MP:0005595 ! abnormal vascular smooth muscle physiology
property_value: dc:date "2023-10-09T10:49:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031509
name: decreased vascular smooth muscle cell proliferation
def: "decrease in the expansion rate of any vascular smooth muscle cell population by cell division" [GO:1990874, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased VSMC proliferation" EXACT []
synonym: "reduced vascular smooth muscle cell proliferation" EXACT []
synonym: "reduced VSMC proliferation" EXACT []
is_a: MP:0000352 ! decreased cell proliferation
is_a: MP:0031508 ! abnormal vascular smooth muscle cell proliferation
property_value: dc:date "2023-10-09T11:09:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031510
name: increased vascular smooth muscle cell proliferation
def: "increase in the expansion rate of any vascular smooth muscle cell population by cell division" [GO:1990874] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "elevated vascular smooth muscle cell proliferation" EXACT []
synonym: "elevated VSMC proliferation" EXACT []
synonym: "increased VSMC proliferation" EXACT []
is_a: MP:0000351 ! increased cell proliferation
is_a: MP:0031508 ! abnormal vascular smooth muscle cell proliferation
property_value: dc:date "2023-10-09T11:16:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031511
name: globular heart
def: "overall shape of the heart is more rounded than usual, lacking a distinct apex" [https://orcid.org/0000-0002-6490-7723, PMID:29078393, PMID:37553261]
synonym: "globose heart" EXACT []
synonym: "round heart" EXACT []
synonym: "rounded heart" EXACT []
is_a: MP:0000277 ! abnormal heart shape
property_value: dc:date "2023-10-17T06:38:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031512
name: abnormal circulating C-peptide level
def: "anomaly in the amount in the blood of the connecting (C) peptide that links the A and B chains in proinsulin" [HP:0030794, PMID:30252282]
comment: C-peptide provides a means to promote the efficient folding and assembly of the A and B chains of proinsulin in the endoplasmic reticulum during insulin biosynthesis; after cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing an independent indicator of insulin secretion.
synonym: "abnormal blood C-peptide level" EXACT []
synonym: "abnormal circulating connecting peptide level" EXACT []
synonym: "abnormal plasma C-peptide level" NARROW []
synonym: "abnormal serum C-peptide level" NARROW []
is_a: MP:0005416 ! abnormal circulating protein level
property_value: dc:date "2023-11-13T16:45:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031513
name: decreased circulating C-peptide level
def: "a reduction in the amount of the C-peptide in the blood" [https://orcid.org/0000-0002-6490-7723]
comment: Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with reduced insulin secretion.
synonym: "decreased blood C-peptide level" EXACT []
synonym: "decreased plasma C-peptide level" NARROW []
synonym: "decreased serum C-peptide level" NARROW []
synonym: "reduced circulating C-peptide level" EXACT []
is_a: MP:0014502 ! decreased circulating protein level
is_a: MP:0031512 ! abnormal circulating C-peptide level
property_value: dc:date "2023-11-13T16:56:16Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031514
name: increased circulating C-peptide level
def: "an elevation in the amount of the C-peptide in the blood" [https://orcid.org/0000-0002-6490-7723]
comment: Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with increased insulin secretion.
synonym: "elevated circulating C-peptide level" EXACT []
synonym: "increased blood C-peptide level" EXACT []
synonym: "increased plasma C-peptide level" NARROW []
synonym: "increased serum C-peptide level" NARROW []
is_a: MP:0014501 ! increased circulating protein level
is_a: MP:0031512 ! abnormal circulating C-peptide level
property_value: dc:date "2023-11-13T17:01:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031515
name: l-loop transposition of the great arteries
def: "a type of transposition of the great arteries (TGA) in which the aorta is positioned to the left and front of the pulmonary artery; it is characterized by atrioventricular and ventriculoarterial discordance and usually associated with ventricular inversion due to leftward looping of the primitive heart tube" [HP:0031349, https://medilib.ir/uptodate/show/83229, ISBN:978-0-12-822224-9]
comment: L-TGA is commonly referred to as congenitally corrected TGA since the blood flows in the correct physiologic direction, resulting in normal oxygenation of the systemic venous return via the abnormally placed ventricles and great arteries.
synonym: "CCTGA" EXACT []
synonym: "congenitally corrected TGA" EXACT []
synonym: "congenitally corrected transposition of the great arteries" EXACT []
synonym: "double discordance" EXACT []
synonym: "L-looped transposition of the great arteries" EXACT []
synonym: "L-TGA" EXACT []
synonym: "L-transposition of the great arteries" EXACT []
synonym: "levo-transposition of the great arteries" EXACT []
synonym: "levotransposition of the great arteries" EXACT []
synonym: "ventricular inversion" EXACT []
is_a: MP:0004110 ! transposition of great arteries
property_value: dc:date "2023-12-04T08:07:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031516
name: mitral valve inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in the mitral valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "inflammation of the bicuspid valve" EXACT []
synonym: "left atrioventricular valve inflammation" EXACT []
synonym: "left AV valve inflammation" EXACT []
is_a: MP:0031118 ! cardiovalvulitis
property_value: dc:date "2023-12-04T09:22:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031517
name: interrupted aortic arch, type c
def: "complete discontinuation/blockage between the ascending and descending aorta with the interruption located between the brachiocephalic (innominate) artery and the left common carotid artery" [https://en.wikipedia.org/wiki/Interrupted_aortic_arch, https://pedecho.org/library/chd/iaa, https://radiopaedia.org/articles/interrupted-aortic-arch, https://www.childrensmercy.org/departments-and-clinics/heart-center/interrupted-aortic-arch/]
synonym: "IAA Type C" EXACT []
synonym: "IAA type c" EXACT []
synonym: "IAA-C" EXACT []
synonym: "interrupted aortic arch type C" EXACT []
synonym: "interrupted aortic arch type c" EXACT []
is_a: MP:0004157 ! interrupted aortic arch
property_value: dc:date "2023-12-04T09:43:27Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031518
name: calcified aortic valve cusp
def: "pathologic deposition of calcium salts in one or more cusps (leaflets) of the aortic valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic cusp calcification" EXACT []
synonym: "aortic leaflet calcification" EXACT []
synonym: "aortic valve cusp calcification" EXACT []
synonym: "aortic valve leaflet calcification" EXACT []
synonym: "calcified aortic valve cusps" EXACT []
synonym: "calcified aortic valve leaflet" EXACT []
synonym: "calcified aortic valve leaflets" EXACT []
is_a: MP:0006116 ! calcified aortic valve
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
property_value: dc:date "2023-12-04T10:56:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031519
name: calcified aortic valve annulus
def: "pathologic deposition of calcium salts in the aortic valve annulus" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic annular calcification" EXACT []
synonym: "aortic annulus calcification" EXACT []
synonym: "aortic anulus calcification" EXACT []
synonym: "aortic valve annulus calcification" EXACT []
synonym: "aortic valve anulus calcification" EXACT []
synonym: "calcified aortic valve anulus" EXACT []
is_a: MP:0006116 ! calcified aortic valve
is_a: MP:0010598 ! abnormal aortic valve annulus morphology
property_value: dc:date "2023-12-04T11:11:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031520
name: calcified mitral valve cusp
def: "pathologic deposition of calcium salts in one or both cusps (leaflets) of the mitral valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "calcified bicuspid valve cusp" EXACT []
synonym: "calcified bicuspid valve cusps" EXACT []
synonym: "calcified bicuspid valve leaflet" EXACT []
synonym: "calcified bicuspid valve leaflets" EXACT []
synonym: "calcified left atrioventricular valve cusp" EXACT []
synonym: "calcified left atrioventricular valve leaflet" EXACT []
synonym: "calcified left AV valve cusp" EXACT []
synonym: "calcified left AV valve leaflet" EXACT []
synonym: "calcified mitral valve cusps" EXACT []
synonym: "calcified mitral valve leaflet" EXACT []
synonym: "calcified mitral valve leaflets" EXACT []
synonym: "mitral cusp calcification" EXACT []
synonym: "mitral leaflet calcification" EXACT []
synonym: "mitral valve cusp calcification" EXACT []
synonym: "mitral valve leaflet calcification" EXACT []
is_a: MP:0006121 ! calcified mitral valve
is_a: MP:0010614 ! abnormal mitral valve cusp morphology
property_value: dc:date "2023-12-04T12:13:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031521
name: calcified mitral valve annulus
def: "pathologic deposition of calcium salts in the mitral valve annulus" [https://orcid.org/0000-0002-6490-7723]
synonym: "bicuspid valve annulus calcification" EXACT []
synonym: "bicuspid valve anulus calcification" EXACT []
synonym: "calcified bicuspid valve annulus" EXACT []
synonym: "calcified bicuspid valve anulus" EXACT []
synonym: "calcified left atrioventricular valve annulus" EXACT []
synonym: "calcified left atrioventricular valve anulus" EXACT []
synonym: "calcified left AV valve annulus" EXACT []
synonym: "calcified left AV valve anulus" EXACT []
synonym: "calcified mitral valve anulus" EXACT []
synonym: "mitral annular calcification" EXACT []
synonym: "mitral annulus calcification" EXACT []
synonym: "mitral valve annulus calcification" EXACT []
is_a: MP:0006121 ! calcified mitral valve
is_a: MP:0010613 ! abnormal mitral valve annulus morphology
property_value: dc:date "2023-12-04T12:25:05Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031522
name: small mitral valve
def: "a decrease in the total area occupied by the mitral valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased bicuspid valve size" EXACT []
synonym: "decreased left atrioventricular valve size" EXACT []
synonym: "decreased left AV valve size" EXACT []
synonym: "decreased mitral valve size" EXACT []
synonym: "small bicuspid valve" EXACT []
synonym: "small left atrioventricular valve" EXACT []
synonym: "small left AV valve" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
is_a: MP:0031572 ! small atrioventricular valve
property_value: dc:date "2023-12-04T12:49:31Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031523
name: mitral valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the mitral valve, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "bicuspid valve hypoplasia" EXACT []
synonym: "hypoplastic bicuspid valve" EXACT []
synonym: "hypoplastic bicuspid valves" EXACT []
synonym: "hypoplastic left atrioventricular valve" EXACT []
synonym: "hypoplastic left AV valve" EXACT []
synonym: "hypoplastic mitral valve" EXACT []
synonym: "hypoplastic mitral valves" EXACT []
synonym: "left atrioventricular valve hypoplasia" EXACT []
synonym: "left AV valve hypoplasia" EXACT []
is_a: MP:0031522 ! small mitral valve
is_a: MP:0031573 ! atrioventricular valve hypoplasia
property_value: dc:date "2023-12-04T13:17:41Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031524
name: mitral valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in the mitral valve, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "bicuspid valve hyperplasia" EXACT []
synonym: "hyperplastic bicuspid valve" EXACT []
synonym: "hyperplastic bicuspid valves" EXACT []
synonym: "hyperplastic left atrioventricular valve" EXACT []
synonym: "hyperplastic left AV valve" EXACT []
synonym: "hyperplastic mitral valve" EXACT []
synonym: "hyperplastic mitral valves" EXACT []
synonym: "left atrioventricular valve hyperplasia" EXACT []
synonym: "left AV valve hyperplasia" EXACT []
is_a: MP:0010618 ! enlarged mitral valve
is_a: MP:0031571 ! atrioventricular valve hyperplasia
property_value: dc:date "2023-12-04T13:24:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031525
name: thin left ventricle myocardium compact layer
def: "decreased myocardium compact layer thickness in the left heart ventricle" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin left ventricle myocardium compact zone" EXACT []
synonym: "thin left ventricular myocardial compact layer" EXACT []
synonym: "thin left ventricular myocardial compact zone" EXACT []
synonym: "thin LV myocardium compact layer" EXACT []
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0010556 ! thin ventricle myocardium compact layer
property_value: dc:date "2023-12-04T13:46:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031526
name: thin right ventricle myocardium compact layer
def: "decreased myocardium compact layer thickness in the right heart ventricle" [https://orcid.org/0000-0002-6490-7723]
synonym: "thin right ventricle myocardium compact zone" EXACT []
synonym: "thin right ventricular myocardial compact layer" EXACT []
synonym: "thin right ventricular myocardial compact zone" EXACT []
synonym: "thin RV myocardium compact layer" EXACT []
is_a: MP:0003920 ! abnormal heart right ventricle morphology
is_a: MP:0010556 ! thin ventricle myocardium compact layer
property_value: dc:date "2023-12-04T13:58:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031527
name: small pulmonary valve
def: "a decrease in the total area occupied by the pulmonary valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased pulmonary valve size" EXACT []
synonym: "decreased pulmonic valve size" EXACT []
synonym: "small pulmonic valve" EXACT []
synonym: "small right arterial valve" EXACT []
synonym: "small right semi-lunar valve" EXACT []
synonym: "small right semilunar valve" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
is_a: MP:0031582 ! small semilunar valve
property_value: dc:date "2023-12-04T14:19:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031528
name: pulmonary valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the pulmonary valve, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic pulmonary valve" EXACT []
synonym: "hypoplastic pulmonary valves" EXACT []
synonym: "hypoplastic pulmonic valve" EXACT []
synonym: "hypoplastic pulmonic valves" EXACT []
synonym: "pulmonic valve hypoplasia" EXACT []
synonym: "right arterial valve hypoplasia" EXACT []
synonym: "right semi-lunar valve hypoplasia" EXACT []
synonym: "right semilunar valve hypoplasia" EXACT []
is_a: MP:0031527 ! small pulmonary valve
is_a: MP:0031583 ! semilunar valve hypoplasia
property_value: dc:date "2023-12-04T14:24:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031529
name: pulmonary valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in the pulmonary valve, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic pulmonary valve" EXACT []
synonym: "hyperplastic pulmonary valves" EXACT []
synonym: "hyperplastic pulmonic valve" EXACT []
synonym: "hyperplastic pulmonic valves" EXACT []
synonym: "pulmonic valve hyperplasia" EXACT []
synonym: "right arterial valve hyperplasia" EXACT []
synonym: "right semi-lunar valve hyperplasia" EXACT []
synonym: "right semilunar valve hyperplasia" EXACT []
is_a: MP:0010600 ! enlarged pulmonary valve
is_a: MP:0031581 ! semilunar valve hyperplasia
property_value: dc:date "2023-12-04T14:33:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031530
name: abnormal heart ventricle shape
def: "any anomaly in the characteristic surface outline or contour of one or both heart ventricles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac ventricle shape" EXACT []
synonym: "abnormal cardiac ventricular shape" EXACT []
synonym: "abnormal heart ventricular shape" EXACT []
is_a: MP:0000277 ! abnormal heart shape
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: dc:date "2023-12-12T13:08:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031531
name: decreased atrioventricular node size
def: "less than average size of the atrioventricular node compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased AV nodal size" EXACT []
synonym: "reduced atrioventricular node size" EXACT []
synonym: "reduced AV nodal size" EXACT []
synonym: "small A-V node" EXACT []
synonym: "small atrioventricular node" EXACT []
synonym: "small AV node" EXACT []
is_a: MP:0004114 ! abnormal atrioventricular node morphology
property_value: dc:date "2023-12-12T13:44:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031532
name: abnormal heart ventricle wall morphology
def: "any structural anomaly of the cardiac wall of the heart ventricles" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal heart ventricular wall morphology" EXACT []
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: dc:date "2023-12-12T17:13:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031533
name: abnormal heart left ventricle wall morphology
def: "any structural anomaly of the cardiac wall of the heart left ventricle" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal heart left ventricular wall morphology" EXACT []
synonym: "abnormal heart LV wall morphology" EXACT []
is_a: MP:0003921 ! abnormal heart left ventricle morphology
is_a: MP:0031532 ! abnormal heart ventricle wall morphology
property_value: dc:date "2023-12-12T17:37:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031534
name: abnormal heart right ventricle wall morphology
def: "any structural anomaly of the cardiac wall of the heart right ventricle" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal heart right ventricular wall morphology" EXACT []
synonym: "abnormal heart RV wall morphology" EXACT []
is_a: MP:0003920 ! abnormal heart right ventricle morphology
is_a: MP:0031532 ! abnormal heart ventricle wall morphology
property_value: dc:date "2023-12-12T18:15:23Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031535
name: abnormal heart atrium wall thickness
def: "anomaly in the depth of the cardiac wall of the heart atria" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal atrial wall thickness" EXACT []
synonym: "abnormal heart atrial wall thickness" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: dc:date "2023-12-13T12:00:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031536
name: decreased heart atrium wall thickness
def: "decreased depth of the cardiac wall of the heart atria" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased atrial wall thickness" EXACT []
synonym: "reduced atrial wall thickness" EXACT []
synonym: "reduced heart atrium wall thickness" EXACT []
synonym: "thin atrial wall" EXACT []
is_a: MP:0031535 ! abnormal heart atrium wall thickness
property_value: dc:date "2023-12-13T12:17:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031537
name: increased heart atrium wall thickness
def: "increased depth of the cardiac wall of the heart atria" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased atrial wall thickness" EXACT []
synonym: "increased heart atrial wall thickness" EXACT []
synonym: "thick atrial wall" EXACT []
is_a: MP:0031535 ! abnormal heart atrium wall thickness
property_value: dc:date "2023-12-13T12:20:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031538
name: quadricuspid aortic valve
def: "presence of four cusps (leaflets) of equal or varying sizes in the aortic valve instead of three" [HP:0031655, https://orcid.org/0000-0002-6490-7723, PMID:28076624]
synonym: "four-cusp aortic valve" EXACT []
synonym: "four-leaflet aortic valve" EXACT []
synonym: "QAV" EXACT []
is_a: MP:0010595 ! abnormal aortic valve cusp morphology
property_value: dc:date "2023-12-13T13:43:40Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031539
name: decreased papillary muscle size
def: "less than average dimensions of one or more of the ventricular papillary muscles" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ventricle papillary muscle size" EXACT []
synonym: "reduced papillary muscle size" EXACT []
synonym: "small papillary muscle" EXACT []
synonym: "small papillary muscles" EXACT []
is_a: MP:0004058 ! abnormal ventricle papillary muscle morphology
property_value: dc:date "2023-12-13T14:35:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031540
name: increased papillary muscle size
def: "greater than average dimensions of one or more of the ventricular papillary muscles" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged papillary muscle" EXACT []
synonym: "enlarged papillary muscles" EXACT []
synonym: "increased ventricle papillary muscle size" EXACT []
is_a: MP:0004058 ! abnormal ventricle papillary muscle morphology
property_value: dc:date "2023-12-13T14:59:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031541
name: decreased sinoatrial node size
def: "reduction in the average size of the sinoatrial node" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced sinoatrial node size" EXACT []
synonym: "small SA node" EXACT []
synonym: "small SAN" EXACT []
synonym: "small sinoatrial node" EXACT []
is_a: MP:0004115 ! abnormal sinoatrial node morphology
property_value: dc:date "2023-12-14T11:20:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031542
name: sinoatrial node hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the sinoatrial node, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic SA node" EXACT []
synonym: "hypoplastic SAN" EXACT []
synonym: "hypoplastic sinoatrial node" EXACT []
synonym: "SA node hypoplasia" EXACT []
synonym: "SAN hypoplasia" EXACT []
is_a: MP:0031541 ! decreased sinoatrial node size
property_value: dc:date "2023-12-14T11:28:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031543
name: abnormal heart ventricle size
def: "anomaly in the average size of either one or both of the heart ventricles compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac ventricle size" EXACT []
synonym: "abnormal heart ventricular size" EXACT []
is_a: MP:0005294 ! abnormal heart ventricle morphology
property_value: dc:date "2023-12-14T14:27:24Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031544
name: decreased heart ventricle size
def: "reduced average size of one or both heart ventricles compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased heart ventricular size" EXACT []
synonym: "reduced heart ventricle size" EXACT []
synonym: "reduced heart ventricular size" EXACT []
synonym: "small heart ventricle" EXACT []
synonym: "small heart ventricles" EXACT []
is_a: MP:0031543 ! abnormal heart ventricle size
property_value: dc:date "2023-12-14T14:47:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031545
name: increased sinoatrial node size
def: "increase in the average size of the sinoatrial node" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged SA node" EXACT []
synonym: "enlarged SAN" EXACT []
synonym: "enlarged sinoatrial node" EXACT []
synonym: "increased SA node size" EXACT []
is_a: MP:0004115 ! abnormal sinoatrial node morphology
property_value: dc:date "2023-12-15T10:29:44Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031546
name: sinoatrial node hyperplasia
def: "increase in the number of normal cells in normal arrangement in the sinoatrial node, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic SA node" EXACT []
synonym: "hyperplastic SAN" EXACT []
synonym: "hyperplastic sinoatrial node" EXACT []
synonym: "SA node hyperplasia" EXACT []
synonym: "SAN hyperplasia" EXACT []
is_a: MP:0031545 ! increased sinoatrial node size
property_value: dc:date "2023-12-15T10:35:53Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031547
name: increased atrioventricular node size
def: "greater than average size of the atrioventricular node" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged A-V node" EXACT []
synonym: "enlarged atrioventricular node" EXACT []
synonym: "enlarged AV node" EXACT []
synonym: "increased AV nodal size" EXACT []
synonym: "increased AV node size" EXACT []
is_a: MP:0004114 ! abnormal atrioventricular node morphology
property_value: dc:date "2023-12-15T11:07:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031548
name: atrioventricular node hyperplasia
def: "increase in the number of normal cells in normal arrangement in the atrioventricular node, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "AV node hyperplasia" EXACT []
synonym: "hyperplastic A-V node" EXACT []
synonym: "hyperplastic atrioventricular node" EXACT []
synonym: "hyperplastic AV node" EXACT []
is_a: MP:0031547 ! increased atrioventricular node size
property_value: dc:date "2023-12-15T11:12:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031549
name: abnormal heart valve development
def: "anomaly in the progression of a heart valve over time, from its formation to the mature structure" [GO:0003170, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac valve development" EXACT []
is_a: MP:0000267 ! abnormal heart development
is_a: MP:0000285 ! abnormal heart valve morphology
property_value: dc:date "2023-12-18T11:38:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031550
name: abnormal atrioventricular valve development
def: "anomaly in the progression of an atrioventricular valve over time, from its formation to the mature structure" [https://orcid.org/0000-0002-6490-7723] {comment="GO:0003171"}
synonym: "abnormal AV valve development" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
is_a: MP:0031549 ! abnormal heart valve development
property_value: dc:date "2023-12-18T11:43:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031551
name: abnormal mitral valve development
def: "anomaly in the progression of the mitral valve over time, from its formation to the mature structure" [GO:0003174, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal bicuspid valve development" EXACT []
synonym: "abnormal left atrioventricular valve development" EXACT []
synonym: "abnormal left AV valve development" EXACT []
is_a: MP:0000286 ! abnormal mitral valve morphology
is_a: MP:0031550 ! abnormal atrioventricular valve development
property_value: dc:date "2023-12-18T11:59:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031552
name: abnormal tricuspid valve development
def: "anomaly in the progression of the tricuspid valve over time, from its formation to the mature structure" [GO:0003175, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal right atrioventricular valve development" EXACT []
synonym: "abnormal right AV valve development" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
is_a: MP:0031550 ! abnormal atrioventricular valve development
property_value: dc:date "2023-12-18T12:08:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031553
name: abnormal semilunar valve development
def: "anomaly in the progression of a semilunar valve over time, from its formation to the mature structure" [GO:1905314, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal semi-lunar valve development" EXACT []
is_a: MP:0002746 ! abnormal semilunar valve morphology
is_a: MP:0031549 ! abnormal heart valve development
property_value: dc:date "2023-12-18T12:16:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031554
name: abnormal aortic valve development
def: "anomaly in the progression of the aortic valve over time, from its formation to the mature structure" [GO:0003176, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal aortic semi-lunar valve development" EXACT []
synonym: "abnormal aortic semilunar valve development" EXACT []
synonym: "abnormal left arterial valve development" EXACT []
synonym: "abnormal left semi-lunar valve development" EXACT []
synonym: "abnormal left semilunar valve development" EXACT []
synonym: "abnormal left ventriculoarterial junction development" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
is_a: MP:0031553 ! abnormal semilunar valve development
property_value: dc:date "2023-12-18T12:21:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031555
name: abnormal pulmonary valve development
def: "anomaly in the progression of the pulmonary valve over time, from its formation to the mature structure" [GO:0003177, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pulmonic valve development" EXACT []
synonym: "abnormal right arterial valve development" EXACT []
synonym: "abnormal right semi-lunar valve development" EXACT []
synonym: "abnormal right semilunar valve development" EXACT []
is_a: MP:0002748 ! abnormal pulmonary valve morphology
is_a: MP:0031553 ! abnormal semilunar valve development
property_value: dc:date "2023-12-18T12:38:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031556
name: abnormal sinoatrial valve development
def: "anomaly in the progression of the sinoatrial valve over time, from its formation to the mature structure" [GO:0003172, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0011646 ! abnormal sinoatrial valve morphology
is_a: MP:0031549 ! abnormal heart valve development
property_value: dc:date "2023-12-18T12:46:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031557
name: small tricuspid valve
def: "a decrease in the total area occupied by the tricuspid valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased right atrioventricular valve size" EXACT []
synonym: "decreased right AV valve size" EXACT []
synonym: "reduced right atrioventricular valve size" EXACT []
synonym: "reduced right AV valve size" EXACT []
synonym: "small right atrioventricular valve" EXACT []
synonym: "small right AV valve" EXACT []
is_a: MP:0002624 ! abnormal tricuspid valve morphology
is_a: MP:0031572 ! small atrioventricular valve
property_value: dc:date "2023-12-18T15:09:32Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031558
name: tricuspid valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in the tricuspid valve, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic right atrioventricular valve" EXACT []
synonym: "hyperplastic right AV valve" EXACT []
synonym: "hyperplastic tricuspid valve" EXACT []
synonym: "right atrioventricular valve hyperplasia" EXACT []
synonym: "right AV valve hyperplasia" EXACT []
is_a: MP:0010627 ! enlarged tricuspid valve
is_a: MP:0031571 ! atrioventricular valve hyperplasia
property_value: dc:date "2023-12-18T15:18:36Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031559
name: tricuspid valve hypertrophy
def: "increase in the bulk size of the tricuspid valve due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic right atrioventricular valve" EXACT []
synonym: "hypertrophic right AV valve" EXACT []
synonym: "hypertrophic tricuspid valve" EXACT []
synonym: "right atrioventricular valve hypertrophy" EXACT []
synonym: "right AV valve hypertrophy" EXACT []
is_a: MP:0010627 ! enlarged tricuspid valve
property_value: dc:date "2023-12-18T15:22:43Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031560
name: decreased ganglioside level
def: "reduction in the concentration of the molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain" [CHEBI:28892, PMID:34928329]
synonym: "diminished ganglioside level" EXACT []
synonym: "reduced ganglioside level" EXACT []
is_a: MP:0012231 ! abnormal ganglioside level
is_a: MP:0014461 ! decreased lipid level
property_value: dc:date "2024-01-08T09:34:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031561
name: increased ganglioside level
def: "increase in the concentration of the molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain" [CHEBI:28892, PMID:34928329]
synonym: "accumulation of ganglioside" EXACT []
synonym: "elevated ganglioside level" EXACT []
is_a: MP:0012231 ! abnormal ganglioside level
is_a: MP:0014460 ! increased lipid level
property_value: dc:date "2024-01-08T09:56:08Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0001-5356-4174
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031562
name: abnormal heart atrium shape
def: "any anomaly in the characteristic surface outline or contour of one or both heart atria" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac atrial shape" EXACT []
synonym: "abnormal cardiac atrium shape" EXACT []
synonym: "abnormal heart atrial shape" EXACT []
is_a: MP:0000277 ! abnormal heart shape
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: dc:date "2024-01-08T17:27:25Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031563
name: pulmonary valve hypertrophy
def: "increase in the bulk size of the pulmonary valve due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypertrophic pulmonary valve" EXACT []
synonym: "hypertrophic pulmonic valve" EXACT []
synonym: "pulmonic valve hypertrophy" EXACT []
synonym: "right arterial valve hypertrophy" EXACT []
synonym: "right semi-lunar valve hypertrophy" EXACT []
synonym: "right semilunar valve hypertrophy" EXACT []
is_a: MP:0010600 ! enlarged pulmonary valve
property_value: dc:date "2024-01-08T18:39:39Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031564
name: mitral valve hypertrophy
def: "increase in the bulk size of the mitral valve due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "bicuspid valve hypertrophy" EXACT []
synonym: "hypertrophic bicuspid valve" EXACT []
synonym: "hypertrophic left atrioventricular valve" EXACT []
synonym: "hypertrophic left AV valve" EXACT []
synonym: "hypertrophic mitral valve" EXACT []
synonym: "left atrioventricular valve hypertrophy" EXACT []
synonym: "left AV valve hypertrophy" EXACT []
is_a: MP:0010618 ! enlarged mitral valve
property_value: dc:date "2024-01-08T18:51:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031565
name: abnormal heart interventricular foramen morphology
def: "any structural anomaly of the temporary opening (space) between the free rim of the muscular interventricular septum and the fused endocardial cushions, allowing for communication between the developing right and left heart ventricles; in normal development, the interventricular foramen closes off when the septum fuses with the endocardial cushions and bulbar ridges to form the membranous part of the interventricular septum" [https://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-120-septation-of-ventricles-truncus-arteriosus-and-conus-cordis, https://ebook.sts.org/sts/view/Cardiac-and-Congenital/1864080/all/Ventricular_Septal_Defects__VSD, https://embryology.med.unsw.edu.au/embryology/index.php?title=Intermediate_-_Atrial_Ventricular_Septation, https://journals.sagepub.com/doi/pdf/10.1177/87564790122250507, UBERON:0013152]
comment: Failure to close the interventricular foramen leads to an interventricular septal defect known as a patent interventricular foramen.
synonym: "abnormal cardiac interventricular foramen morphology" EXACT []
synonym: "abnormal primary interventricular foramen morphology" EXACT []
is_a: MP:0000267 ! abnormal heart development
property_value: dc:date "2024-01-09T11:31:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031566
name: small aortic valve
def: "a decrease in the total area occupied by the aortic valve" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased aortic valve size" EXACT []
synonym: "reduced aortic valve size" EXACT []
synonym: "small aortic semi-lunar valve" EXACT []
synonym: "small aortic semilunar valve" EXACT []
synonym: "small left arterial valve" EXACT []
synonym: "small left semi-lunar valve" EXACT []
synonym: "small left semilunar valve" EXACT []
synonym: "small left ventriculoarterial junction" EXACT []
is_a: MP:0002747 ! abnormal aortic valve morphology
is_a: MP:0031582 ! small semilunar valve
property_value: dc:date "2024-01-09T12:29:00Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031567
name: aortic valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in the aortic valve, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic semi-lunar valve hypoplasia" EXACT []
synonym: "aortic semilunar valve hypoplasia" EXACT []
synonym: "hypoplastic aortic valve" EXACT []
synonym: "left arterial valve hypoplasia" EXACT []
synonym: "left semi-lunar valve hypoplasia" EXACT []
synonym: "left semilunar valve hypoplasia" EXACT []
synonym: "left ventriculoarterial junction hypoplasia" EXACT []
is_a: MP:0031566 ! small aortic valve
is_a: MP:0031583 ! semilunar valve hypoplasia
property_value: dc:date "2024-01-09T12:35:33Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031568
name: aortic valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in the aortic valve, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic semi-lunar valve hyperplasia" EXACT []
synonym: "aortic semilunar valve hyperplasia" EXACT []
synonym: "hyperplastic aortic valve" EXACT []
synonym: "left arterial valve hyperplasia" EXACT []
synonym: "left semi-lunar valve hyperplasia" EXACT []
synonym: "left semilunar valve hyperplasia" EXACT []
synonym: "left ventriculoarterial junction hyperplasia" EXACT []
is_a: MP:0010591 ! enlarged aortic valve
is_a: MP:0031581 ! semilunar valve hyperplasia
property_value: dc:date "2024-01-09T12:40:51Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031569
name: aortic valve hypertrophy
def: "increase in the bulk size of the aortic valve due to cell enlargement" [https://orcid.org/0000-0002-6490-7723]
synonym: "aortic semi-lunar valve hypertrophy" EXACT []
synonym: "aortic semilunar valve hypertrophy" EXACT []
synonym: "hypertrophic aortic valve" EXACT []
synonym: "left arterial valve hypertrophy" EXACT []
synonym: "left semi-lunar valve hypertrophy" EXACT []
synonym: "left semilunar valve hypertrophy" EXACT []
synonym: "left ventriculoarterial junction hypertrophy" EXACT []
is_a: MP:0010591 ! enlarged aortic valve
property_value: dc:date "2024-01-09T12:45:12Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031570
name: enlarged atrioventricular valve
def: "an increase in the total area occupied by either one or both of the atrioventricular valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged atrioventricular valves" EXACT []
synonym: "enlarged AV valve" EXACT []
synonym: "increased atrioventricular valve size" EXACT []
synonym: "increased AV valve size" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: dc:date "2024-01-09T13:15:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031571
name: atrioventricular valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in either one or both of the atrioventricular valves, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "AV valve hyperplasia" EXACT []
synonym: "hyperplastic atrioventricular valve" EXACT []
synonym: "hyperplastic atrioventricular valves" EXACT []
synonym: "hyperplastic AV valve" EXACT []
synonym: "hyperplastic AV valves" EXACT []
is_a: MP:0003958 ! heart valve hyperplasia
is_a: MP:0031570 ! enlarged atrioventricular valve
property_value: dc:date "2024-01-09T13:21:52Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031572
name: small atrioventricular valve
def: "a decrease in the total area occupied by either one or both of the atrioventricular valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased atrioventricular valve size" EXACT []
synonym: "decreased AV valve size" EXACT []
synonym: "reduced atrioventricular valve size" EXACT []
synonym: "reduced AV valve size" EXACT []
synonym: "small atrioventricular valves" EXACT []
synonym: "small AV valve" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: dc:date "2024-01-09T13:37:57Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031573
name: atrioventricular valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in either one or both of the atrioventricular valves, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "AV valve hypoplasia" EXACT []
synonym: "hypoplastic atrioventricular valve" EXACT []
synonym: "hypoplastic atrioventricular valves" EXACT []
synonym: "hypoplastic AV valve" EXACT []
synonym: "hypoplastic AV valves" EXACT []
is_a: MP:0000287 ! heart valve hypoplasia
is_a: MP:0031572 ! small atrioventricular valve
property_value: dc:date "2024-01-09T13:46:04Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031574
name: thick atrioventricular valve
def: "an increase in the ratio of an atrioventricular valve wall thickness to the atrioventricular septum thickness" [https://orcid.org/0000-0002-6490-7723]
synonym: "thick atrioventricular valves" EXACT []
synonym: "thick AV valve" EXACT []
synonym: "thickened atrioventricular valve" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: dc:date "2024-01-09T13:55:36Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031575
name: atrioventricular valve stenosis
def: "abnormal narrowing or constriction of either one or both of the atrioventricular valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "AV valve stenosis" EXACT []
synonym: "stenotic atrioventricular valve" EXACT []
synonym: "stenotic atrioventricular valves" EXACT []
synonym: "stenotic AV valve" EXACT []
is_a: MP:0002745 ! abnormal atrioventricular valve morphology
property_value: dc:date "2024-01-09T14:05:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031576
name: abnormal heart atrium size
def: "anomaly in the average size of either one or both of the heart atria compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiac atrial size" EXACT []
synonym: "abnormal cardiac atrium size" EXACT []
synonym: "abnormal heart atrial size" EXACT []
is_a: MP:0003105 ! abnormal heart atrium morphology
property_value: dc:date "2024-01-09T15:54:59Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031577
name: decreased heart atrium size
def: "reduced average size of either one or both of the heart atria compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased cardiac atrium size" EXACT []
synonym: "decreased heart atrial size" EXACT []
synonym: "reduced heart atrial size" EXACT []
synonym: "small cardiac atrium" EXACT []
synonym: "small heart atria" EXACT []
synonym: "small heart atrium" EXACT []
is_a: MP:0031576 ! abnormal heart atrium size
property_value: dc:date "2024-01-09T16:12:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031578
name: decreased heart left atrium size
def: "less than average size of the heart left atrium compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased heart left atrial size" EXACT []
synonym: "decreased left cardiac atrium size" EXACT []
synonym: "reduced heart left atrium size" EXACT []
synonym: "small heart left atrium" EXACT []
is_a: MP:0003923 ! abnormal heart left atrium morphology
is_a: MP:0031577 ! decreased heart atrium size
property_value: dc:date "2024-01-09T16:47:54Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031579
name: decreased heart right atrium size
def: "less than average size of the heart right atrium compared to the average for a particular population" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased heart right atrial size" EXACT []
synonym: "decreased right cardiac atrium size" EXACT []
synonym: "reduced heart right atrial size" EXACT []
synonym: "reduced heart right atrium size" EXACT []
synonym: "small heart right atrium" EXACT []
synonym: "small right cardiac atrium" EXACT []
is_a: MP:0003922 ! abnormal heart right atrium morphology
is_a: MP:0031577 ! decreased heart atrium size
property_value: dc:date "2024-01-09T17:09:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031580
name: enlarged semilunar valve
def: "an increase in the total area occupied by either one or both of the semilunar valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged outflow tract valve" EXACT []
synonym: "enlarged semi-lunar valve" EXACT []
synonym: "increased outflow tract valve size" EXACT []
synonym: "increased semi-lunar valve size" EXACT []
synonym: "increased semilunar valve size" EXACT []
is_a: MP:0002746 ! abnormal semilunar valve morphology
property_value: dc:date "2024-01-10T12:42:17Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031581
name: semilunar valve hyperplasia
def: "increase in the number of normal cells in normal arrangement in either one or both of the semilunar valves, typically resulting in increased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hyperplastic outflow tract valve" EXACT []
synonym: "hyperplastic semi-lunar valve" EXACT []
synonym: "hyperplastic semilunar valve" EXACT []
synonym: "outflow tract valve hyperplasia" EXACT []
synonym: "semi-lunar valve hyperplasia" EXACT []
is_a: MP:0003958 ! heart valve hyperplasia
is_a: MP:0031580 ! enlarged semilunar valve
property_value: dc:date "2024-01-10T12:51:02Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031582
name: small semilunar valve
def: "a decrease in the total area occupied by either one or both of the semilunar valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased semi-lunar valve size" EXACT []
synonym: "decreased semilunar valve size" EXACT []
synonym: "reduced semi-lunar valve size" EXACT []
synonym: "reduced semilunar valve size" EXACT []
synonym: "small outflow tract valve" EXACT []
synonym: "small semi-lunar valve" EXACT []
is_a: MP:0002746 ! abnormal semilunar valve morphology
property_value: dc:date "2024-01-10T13:01:46Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031583
name: semilunar valve hypoplasia
def: "decrease in the number of normal cells in normal arrangement in either one or both of the semilunar valves, typically resulting in decreased size" [https://orcid.org/0000-0002-6490-7723]
synonym: "hypoplastic outflow tract valve" EXACT []
synonym: "hypoplastic semi-lunar valve" EXACT []
synonym: "hypoplastic semilunar valve" EXACT []
synonym: "outflow tract valve hypoplasia" EXACT []
synonym: "semi-lunar valve hypoplasia" EXACT []
is_a: MP:0000287 ! heart valve hypoplasia
is_a: MP:0031582 ! small semilunar valve
property_value: dc:date "2024-01-10T13:18:37Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031584
name: thick semilunar valve
def: "an increase in the ratio of a semilunar valve wall thickness to its corresponding arterial wall thickness" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased semi-lunar valve thickness" EXACT []
synonym: "increased semilunar valve thickness" EXACT []
synonym: "thick outflow tract valve" EXACT []
synonym: "thick semi-lunar valve" EXACT []
synonym: "thickened semi-lunar valve" EXACT []
synonym: "thickened semilunar valve" EXACT []
is_a: MP:0002746 ! abnormal semilunar valve morphology
property_value: dc:date "2024-01-10T13:35:10Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031585
name: semilunar valve stenosis
def: "abnormal narrowing or constriction of either one or both of the semilunar valves" [https://orcid.org/0000-0002-6490-7723]
synonym: "outflow tract valve stenosis" EXACT []
synonym: "semi-lunar valve stenosis" EXACT []
synonym: "stenotic outflow tract valve" EXACT []
synonym: "stenotic semi-lunar valve" EXACT []
synonym: "stenotic semilunar valve" EXACT []
is_a: MP:0002746 ! abnormal semilunar valve morphology
property_value: dc:date "2024-01-10T13:48:38Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031586
name: perivascular cardiac fibrosis
def: "deposition of fibrous connective tissue in spaces surrounding blood vessels in the heart, often resulting from inflammation or injury" [HP:0031328, https://orcid.org/0000-0002-6490-7723, https://www.jmcc-online.com/article/S0022-2828%2815%2930110-3/fulltext]
is_a: MP:0003141 ! cardiac fibrosis
is_a: MP:0011749 ! perivascular fibrosis
property_value: dc:date "2024-01-10T14:12:56Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031587
name: abnormal pericardium development
def: "any anomaly in the process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure" [GO:0060039, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pericardial development" EXACT []
is_a: MP:0000267 ! abnormal heart development
is_a: MP:0000288 ! abnormal pericardium morphology
property_value: dc:date "2024-02-05T11:31:18Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031588
name: distended epicardium
def: "an expansion in the volume of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "dilated epicardium" EXACT []
synonym: "distended visceral serous pericardium of heart" EXACT []
synonym: "distended visceral serous pericardium proper" EXACT []
synonym: "epicardial distension" EXACT []
is_a: MP:0003057 ! abnormal epicardium morphology
property_value: dc:date "2024-02-05T12:04:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031589
name: detached epicardium
def: "partial or complete dissociation of the epicardium from the underlying myocardium" [https://orcid.org/0000-0002-6490-7723]
synonym: "detached visceral serous pericardium of heart" EXACT []
synonym: "detached visceral serous pericardium proper" EXACT []
synonym: "epicardial detachment" EXACT []
synonym: "epicardial dissociation" EXACT []
is_a: MP:0003057 ! abnormal epicardium morphology
property_value: dc:date "2024-02-05T12:19:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031590
name: abnormal epicardium development
def: "any anomaly in the the progression of the heart epicardium over time, from its formation to the mature structure" [GO:0061032, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal development of the visceral serous pericardium of heart" EXACT []
synonym: "abnormal epicardial development" EXACT []
synonym: "abnormal visceral serous pericardium proper development" EXACT []
is_a: MP:0003057 ! abnormal epicardium morphology
is_a: MP:0031587 ! abnormal pericardium development
property_value: dc:date "2024-02-05T12:39:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031591
name: detached endocardium
def: "partial or complete dissociation of the endocardium from the myocardial layer" [] {comment="https://orcid.org/0000-0002-6490-7723"}
synonym: "detached endocardial lining" EXACT []
synonym: "endocardial detachment" EXACT []
synonym: "endocardial dissociation" EXACT []
is_a: MP:0003974 ! abnormal endocardium morphology
property_value: dc:date "2024-02-05T13:32:06Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031592
name: abnormal endocardium development
def: "any anomaly in the process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure" [GO:0003157, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal endocardial development" EXACT []
is_a: MP:0000267 ! abnormal heart development
is_a: MP:0003974 ! abnormal endocardium morphology
property_value: dc:date "2024-02-05T13:36:20Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031593
name: decreased cardiac jelly amount
def: "reduction in the amount of the gelatinous non-cellular material present between the endothelial lining and the myocardial layer of the developing heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced cardiac jelly amount" EXACT []
is_a: MP:0009382 ! abnormal cardiac jelly morphology
property_value: dc:date "2024-02-05T13:55:22Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031594
name: increased cardiac jelly amount
def: "increase in the amount of the gelatinous non-cellular material present between the endothelial lining and the myocardial layer of the developing heart" [https://orcid.org/0000-0002-6490-7723]
synonym: "expanded cardiac jelly" EXACT []
is_a: MP:0009382 ! abnormal cardiac jelly morphology
property_value: dc:date "2024-02-05T14:00:50Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031595
name: abnormal adipose tissue apoptosis
def: "change in the timing or the number of cells in adipose tissue undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0001648 ! abnormal apoptosis
is_a: MP:0005666 ! abnormal adipose tissue physiology
property_value: dc:date "2024-02-05T15:05:19Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031596
name: decreased adipose tissue apoptosis
def: "reduction in the number of adipose tissue cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced adipose tissue apoptosis" EXACT []
is_a: MP:0006043 ! decreased apoptosis
is_a: MP:0031595 ! abnormal adipose tissue apoptosis
property_value: dc:date "2024-02-05T15:14:14Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031597
name: increased adipose tissue apoptosis
def: "increase in the number of adipose tissue cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated adipose tissue apoptosis" EXACT []
is_a: MP:0006042 ! increased apoptosis
is_a: MP:0031595 ! abnormal adipose tissue apoptosis
property_value: dc:date "2024-02-05T15:18:29Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031598
name: abnormal white adipose tissue apoptosis
def: "change in the timing or the number of cells in white adipose tissue undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal WAT apoptosis" EXACT []
is_a: MP:0005670 ! abnormal white adipose tissue physiology
is_a: MP:0031595 ! abnormal adipose tissue apoptosis
property_value: dc:date "2024-02-05T15:21:26Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031599
name: decreased white adipose tissue apoptosis
def: "reduction in the number of white adipose tissue cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased WAT apoptosis" EXACT []
synonym: "reduced WAT apoptosis" EXACT []
is_a: MP:0031596 ! decreased adipose tissue apoptosis
is_a: MP:0031598 ! abnormal white adipose tissue apoptosis
property_value: dc:date "2024-02-05T15:26:42Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031600
name: increased white adipose tissue apoptosis
def: "increase in the number of white adipose tissue cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated WAT apoptosis" EXACT []
synonym: "increased WAT apoptosis" EXACT []
is_a: MP:0031597 ! increased adipose tissue apoptosis
is_a: MP:0031598 ! abnormal white adipose tissue apoptosis
property_value: dc:date "2024-02-05T15:31:49Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031601
name: decreased endoplasmic reticulum stress
def: "reduction in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen in response to stimulation by genetic or environmental factors" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased ER stress" EXACT []
synonym: "reduced endoplasmic reticulum stress" EXACT []
synonym: "reduced ER stress" EXACT []
is_a: MP:0020353 ! abnormal endoplasmic reticulum stress
property_value: dc:date "2024-02-19T12:21:35Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031602
name: white adipose tissue inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in white adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "WAT inflammation" EXACT []
is_a: MP:0005670 ! abnormal white adipose tissue physiology
is_a: MP:0020386 ! adipose tissue inflammation
property_value: dc:date "2024-02-19T14:42:11Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031603
name: brown adipose tissue inflammation
def: "local accumulation of fluid, plasma proteins, and leukocytes in brown adipose tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "BAT inflammation" EXACT []
is_a: MP:0011698 ! abnormal brown adipose tissue physiology
is_a: MP:0020386 ! adipose tissue inflammation
property_value: dc:date "2024-02-19T14:46:47Z" xsd:dateTime
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031604
name: abnormal susceptibility to age-related retinal degeneration
def: "a change in the likelihood that an organism will develop retinal degeneration that is progressive with age" [https://orcid.org/0000-0002-6490-7723]
synonym: "altered susceptibility to age-related retinal degeneration" EXACT []
is_a: MP:0001325 ! abnormal retina morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T12:33:20Z" xsd:string

[Term]
id: MP:0031605
name: decreased susceptibility to age-related retinal degeneration
def: "less likely than normal to develop retinal degeneration that is progressive with age" [https://orcid.org/0000-0002-6490-7723]
synonym: "increased resistance to age-related retinal degeneration" EXACT []
synonym: "reduced susceptibility to age-related retinal degeneration" EXACT []
is_a: MP:0031604 ! abnormal susceptibility to age-related retinal degeneration
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T12:40:14Z" xsd:dateTime

[Term]
id: MP:0031606
name: increased susceptibility to age-related retinal degeneration
def: "more likely than normal to develop retinal degeneration that is progressive with age" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased resistance to age-related retinal degeneration" EXACT []
synonym: "reduced resistance to age-related retinal degeneration" EXACT []
is_a: MP:0031604 ! abnormal susceptibility to age-related retinal degeneration
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T12:44:10Z" xsd:dateTime

[Term]
id: MP:0031607
name: abnormal fetal cardiomyocyte mitochondrial morphology
def: "any structural anomaly of the semiautonomous, self replicating organelles in fetal and neonatal cardiomyocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal cardiomyoblast mitochondria morphology" EXACT []
synonym: "abnormal cardiomyoblast mitochondrial morphology" EXACT []
synonym: "abnormal fetal cardiomyocyte mitochondria morphology" EXACT []
synonym: "abnormal foetal cardiomyocyte mitochondria morphology" EXACT []
synonym: "abnormal foetal cardiomyocyte mitochondrial morphology" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
is_a: MP:0014342 ! abnormal muscle fiber mitochondrial morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T15:12:50Z" xsd:dateTime

[Term]
id: MP:0031608
name: decreased fetal cardiomyocyte size
def: "reduced size of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased foetal cardiomyocyte size" EXACT []
synonym: "reduced fetal cardiomyocyte size" EXACT []
synonym: "reduced foetal cardiomyocyte size" EXACT []
synonym: "small fetal cardiomyocyte" EXACT []
synonym: "small foetal cardiomyocyte" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T15:21:22Z" xsd:dateTime

[Term]
id: MP:0031609
name: increased fetal cardiomyocyte size
def: "increased size of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "enlarged fetal cardiomyocyte" EXACT []
synonym: "enlarged foetal cardiomyocyte" EXACT []
synonym: "fetal cardiomyocyte hypertrophy" EXACT []
synonym: "foetal cardiomyocyte hypertrophy" EXACT []
synonym: "increased foetal cardiomyocyte size" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T15:27:26Z" xsd:dateTime

[Term]
id: MP:0031610
name: abnormal fetal cardiomyocyte number
def: "any anomaly of the number of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal foetal cardiomyocyte number" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T17:38:51Z" xsd:dateTime

[Term]
id: MP:0031611
name: decreased fetal cardiomyocyte number
def: "decrease in the number of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased foetal cardiomyocyte number" EXACT []
synonym: "reduced fetal cardiomyocyte number" EXACT []
synonym: "reduced foetal cardiomyocyte number" EXACT []
is_a: MP:0031610 ! abnormal fetal cardiomyocyte number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T17:42:04Z" xsd:dateTime

[Term]
id: MP:0031612
name: increased fetal cardiomyocyte number
def: "increase in the number of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated fetal cardiomyocyte number" EXACT []
synonym: "elevated foetal cardiomyocyte number" EXACT []
synonym: "increased foetal cardiomyocyte number" EXACT []
is_a: MP:0031610 ! abnormal fetal cardiomyocyte number
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T17:45:58Z" xsd:dateTime

[Term]
id: MP:0031613
name: fetal cardiomyocyte disarray
def: "disorganization or loss of the normal orientation and/or alignment of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "foetal cardiomyocyte disarray" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T17:49:12Z" xsd:dateTime

[Term]
id: MP:0031614
name: fetal cardiomyocyte vacuoles
def: "abnormal presence of fluid-filled vesicles in the cytoplasm of the fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [https://orcid.org/0000-0002-6490-7723]
synonym: "foetal cardiomyocyte vacuoles" EXACT []
synonym: "vacuolated fetal cardiomyocytes" EXACT []
synonym: "vacuolated foetal cardiomyocytes" EXACT []
is_a: MP:0008788 ! abnormal fetal cardiomyocyte morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-04T17:54:09Z" xsd:dateTime

[Term]
id: MP:0031615
name: decreased muscle glycogen level
def: "less than the normal concentration of a readily converted carbohydrate reserve in any muscle tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced muscle glycogen level" EXACT []
is_a: MP:0005439 ! decreased glycogen level
is_a: MP:0014068 ! abnormal muscle glycogen level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-11T10:48:09Z" xsd:dateTime

[Term]
id: MP:0031616
name: increased muscle glycogen level
def: "greater than the normal concentration of a readily converted carbohydrate reserve in any muscle tissue" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated muscle glycogen level" EXACT []
is_a: MP:0005440 ! increased glycogen level
is_a: MP:0014068 ! abnormal muscle glycogen level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-11T11:07:58Z" xsd:dateTime

[Term]
id: MP:0031617
name: abnormal skeletal muscle cell glucose uptake
def: "anomaly in the ability of any skeletal muscle cells to take in glucose" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0004130 ! abnormal muscle cell glucose uptake
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-11T13:21:03Z" xsd:string

[Term]
id: MP:0031618
name: decreased skeletal muscle cell glucose uptake
def: "reduced ability of any skeletal muscle cells to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "impaired skeletal muscle cell glucose uptake" EXACT []
synonym: "reduced skeletal muscle cell glucose uptake" EXACT []
is_a: MP:0030022 ! decreased muscle cell glucose uptake
is_a: MP:0031617 ! abnormal skeletal muscle cell glucose uptake
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-11T13:34:33Z" xsd:dateTime

[Term]
id: MP:0031619
name: increased skeletal muscle cell glucose uptake
def: "increased ability of any skeletal muscle cells to take in glucose" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced skeletal muscle cell glucose uptake" EXACT []
synonym: "improved skeletal muscle cell glucose uptake" EXACT []
is_a: MP:0030021 ! increased muscle cell glucose uptake
is_a: MP:0031617 ! abnormal skeletal muscle cell glucose uptake
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-03-11T13:42:11Z" xsd:string

[Term]
id: MP:0031620
name: abnormal chromatoid body morphology
def: "any structural anomaly in the ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network" [GO:0033391, https://orcid.org/0000-0002-6490-7723]
is_a: MP:0006362 ! abnormal male germ cell morphology
is_a: MP:0014239 ! abnormal intracellular organelle morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723

[Term]
id: MP:0031621
name: small dental pulp chamber
def: "decreased size of the portion of the dental pulp cavity within the crown of a tooth" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased coronal pulp chamber size" EXACT []
synonym: "decreased dental pulp chamber size" EXACT []
synonym: "reduced dental pulp chamber size" EXACT []
synonym: "small coronal pulp chamber" EXACT []
synonym: "small dental pulp chambers" EXACT []
synonym: "small tooth pulp chambers" EXACT []
is_a: MP:0030561 ! abnormal dental pulp chamber morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T08:32:14Z" xsd:string

[Term]
id: MP:0031622
name: small dental pulp canal
def: "decreased size of the portion of the dental pulp cavity within the root of a tooth" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased dental pulp canal size" EXACT []
synonym: "decreased radicular pulp size" EXACT []
synonym: "reduced dental pulp canal size" EXACT []
synonym: "small dental pulp canals" EXACT []
synonym: "small pulp canals" EXACT []
synonym: "small radicular pulp" EXACT []
synonym: "small root canals" EXACT []
synonym: "small tooth pulp canals" EXACT []
is_a: MP:0030559 ! abnormal dental pulp canal morphology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T09:39:54Z" xsd:dateTime

[Term]
id: MP:0031623
name: abnormal tooth physiology
def: "any functional anomaly of the hard or soft tissues of the skeletal element within the mouth that is composed of dentine and used to procure or masticate food" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal tooth function" EXACT []
is_a: MP:0001533 ! abnormal skeleton physiology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T11:04:54Z" xsd:dateTime

[Term]
id: MP:0031624
name: abnormal dental pulp cell apoptosis
def: "change in the timing or the number of cells in dental pulp tissue undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0031623 ! abnormal tooth physiology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T11:34:47Z" xsd:dateTime

[Term]
id: MP:0031625
name: decreased dental pulp cell apoptosis
def: "reduction in the number of dental pulp cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced dental pulp cell apoptosis" EXACT []
is_a: MP:0031624 ! abnormal dental pulp cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T11:47:30Z" xsd:dateTime

[Term]
id: MP:0031626
name: increased dental pulp cell apoptosis
def: "increase in the number of dental pulp cells undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723, PMID:38105557]
synonym: "elevated dental pulp cell apoptosis" EXACT []
is_a: MP:0031624 ! abnormal dental pulp cell apoptosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-05-20T11:54:55Z" xsd:dateTime

[Term]
id: MP:0031627
name: abnormal copulation physiology
def: "any anomaly in the physiological processes involved in the act of sexual union that normally enables the transfer of ejaculate (sperm) from male to female" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal copulatory physiology" EXACT []
is_a: MP:0001919 ! abnormal reproductive system physiology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-05T09:14:51Z" xsd:dateTime

[Term]
id: MP:0031628
name: abnormal intromission
def: "any anomaly in the insertion or period of insertion of the penis into the vagina in copulation" [https://www.merriam-webster.com/dictionary/intromission, PMID:3593827, PMID:9037078]
synonym: "abnormal intravaginal penile insertion" EXACT []
synonym: "abnormal intravaginal penis insertion" EXACT []
is_a: MP:0009697 ! abnormal copulation behavior
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-05T10:31:17Z" xsd:dateTime

[Term]
id: MP:0031629
name: abnormal mounting behavior
def: "any anomaly in the behavior during which a male typically climbs onto a female adopting a position that facilitates copulation; in mammals, mounting usually consists of a male's standing on his hindlegs and grasping a female's flanks from behind" [http://ndl.ethernet.edu.et/bitstream/123456789/718/1/66.pdf.pdf, ISBN:9780128132524]
comment: In rodents, the male assumes a copulatory position that is dorsally and from the rear. Mounting is mostly associated with thrusting motions of the hindquarters (pelvic thrusts). During mounting, the male lifts his forebody over the female hindquarters, clasping her flanks with its forepaws while keeping its hindlegs on the floor, and begins a series of rapid shallow movements of the pelvis without achieving penetration. Mounting may or may not result in intromission. {xref="PMID:37324524"}
synonym: "abnormal mounting behaviour" EXACT []
is_a: MP:0009697 ! abnormal copulation behavior
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-05T10:58:06Z" xsd:dateTime

[Term]
id: MP:0031630
name: abnormal lung cholesterol level
def: "aberrant amount in the lung of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal pulmonary cholesterol level" EXACT []
is_a: MP:0001175 ! abnormal lung morphology
is_a: MP:0003947 ! abnormal cholesterol level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T10:21:46Z" xsd:dateTime

[Term]
id: MP:0031631
name: decreased lung cholesterol level
def: "less than normal amount in the lung of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased pulmonary cholesterol level" EXACT []
synonym: "reduced lung cholesterol level" EXACT []
synonym: "reduced pulmonary cholesterol level" EXACT []
is_a: MP:0003983 ! decreased cholesterol level
is_a: MP:0031630 ! abnormal lung cholesterol level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T10:35:18Z" xsd:dateTime

[Term]
id: MP:0031632
name: increased lung cholesterol level
def: "greater than normal amount in the lung of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [https://orcid.org/0000-0002-6490-7723, PMID:37890669]
synonym: "elevated lung cholesterol level" EXACT []
synonym: "elevated pulmonary cholesterol level" EXACT []
synonym: "increased pulmonary cholesterol level" EXACT []
is_a: MP:0003982 ! increased cholesterol level
is_a: MP:0031630 ! abnormal lung cholesterol level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T10:41:43Z" xsd:dateTime

[Term]
id: MP:0031633
name: decreased heart left ventricle muscle contractility
def: "reduced ability of the heart left ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased left ventricle muscle contractility" EXACT []
synonym: "decreased left ventricular ejection fraction" NARROW []
synonym: "decreased left ventricular muscle contractility" EXACT []
synonym: "impaired left ventricle muscle contractility" EXACT []
synonym: "reduced left ventricle muscle contractility" EXACT []
is_a: MP:0005598 ! decreased heart ventricle muscle contractility
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T11:54:37Z" xsd:dateTime

[Term]
id: MP:0031634
name: decreased heart right ventricle muscle contractility
def: "reduced ability of the heart right ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased right ventricle muscle contractility" EXACT []
synonym: "decreased right ventricular ejection fraction" NARROW []
synonym: "decreased right ventricular muscle contractility" EXACT []
synonym: "impaired right ventricle muscle contractility" EXACT []
synonym: "reduced right ventricle muscle contractility" EXACT []
is_a: MP:0005598 ! decreased heart ventricle muscle contractility
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T12:44:11Z" xsd:dateTime

[Term]
id: MP:0031635
name: increased heart left ventricle muscle contractility
def: "greater than the normal ability of the heart left ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced left ventricle muscle contractility" EXACT []
synonym: "increased left ventricle muscle contractility" EXACT []
synonym: "increased left ventricular ejection fraction" NARROW []
synonym: "increased left ventricular muscle contractility" EXACT []
is_a: MP:0005600 ! increased heart ventricle muscle contractility
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T16:29:43Z" xsd:dateTime

[Term]
id: MP:0031636
name: increased heart right ventricle muscle contractility
def: "greater than the normal ability of the heart right ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume" [https://orcid.org/0000-0002-6490-7723]
synonym: "enhanced right ventricle muscle contractility" EXACT []
synonym: "increased right ventricle muscle contractility" EXACT []
synonym: "increased right ventricular ejection fraction" NARROW []
synonym: "increased right ventricular muscle contractility" EXACT []
is_a: MP:0005600 ! increased heart ventricle muscle contractility
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-06-10T16:46:35Z" xsd:dateTime

[Term]
id: MP:0031637
name: methioninuria
def: "excretion of excessive amounts of methionine in the urine" [HP:0032352]
synonym: "increased urinary methionine level" EXACT []
synonym: "increased urine methionine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030641 ! increased methionine level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T09:47:28Z" xsd:dateTime

[Term]
id: MP:0031638
name: abnormal alanine level
def: "anomaly in the amount of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal 2-aminopropanoic acid level" EXACT []
is_a: MP:0005332 ! abnormal amino acid level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T10:52:06Z" xsd:dateTime

[Term]
id: MP:0031639
name: decreased alanine level
def: "reduction in the amount of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "decreased 2-aminopropanoic acid level" EXACT []
synonym: "reduced 2-aminopropanoic acid level" EXACT []
synonym: "reduced alanine level" EXACT []
is_a: MP:0014528 ! decreased amino acid level
is_a: MP:0031638 ! abnormal alanine level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T10:56:22Z" xsd:dateTime

[Term]
id: MP:0031640
name: increased alanine level
def: "increase in the amount of alanine, an alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2" [CHEBI:16449, https://orcid.org/0000-0002-6490-7723]
synonym: "elevated 2-aminopropanoic acid level" EXACT []
synonym: "elevated alanine level" EXACT []
synonym: "increased 2-aminopropanoic acid level" EXACT []
is_a: MP:0014527 ! increased amino acid level
is_a: MP:0031638 ! abnormal alanine level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T11:00:57Z" xsd:dateTime

[Term]
id: MP:0031641
name: alaninuria
def: "excretion of excessive amounts of alanine in the urine" [HP:0020078, https://orcid.org/0000-0002-6490-7723]
synonym: "increased urinary alanine level" EXACT []
synonym: "increased urine alanine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0031640 ! increased alanine level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T11:26:52Z" xsd:dateTime

[Term]
id: MP:0031642
name: phenylalaninuria
def: "excretion of excessive amounts of phenylalanine in the urine" [HP:0032351, https://orcid.org/0000-0002-6490-7723]
synonym: "increased urinary phenylalanine level" EXACT []
synonym: "increased urine phenylalanine level" EXACT []
is_a: MP:0003311 ! aminoaciduria
is_a: MP:0030697 ! increased phenylalanine level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T11:32:34Z" xsd:dateTime

[Term]
id: MP:0031643
name: abnormal myocardial fiber apoptosis
def: "change in the timing or the number of adult cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal adult cardiomyocyte apoptosis" EXACT []
synonym: "abnormal myocardial fibre apoptosis" EXACT []
is_a: MP:0003221 ! abnormal cardiomyocyte apoptosis
is_a: MP:0004215 ! abnormal myocardial fiber physiology
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T16:24:07Z" xsd:dateTime

[Term]
id: MP:0031644
name: decreased myocardial fiber apoptosis
def: "reduction in the number of adult cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased adult cardiomyocyte apoptosis" EXACT []
synonym: "decreased myocardial fibre apoptosis" EXACT []
synonym: "reduced adult cardiomyocyte apoptosis" EXACT []
synonym: "reduced myocardial fiber apoptosis" EXACT []
synonym: "reduced myocardial fibre apoptosis" EXACT []
is_a: MP:0003223 ! decreased cardiomyocyte apoptosis
is_a: MP:0031643 ! abnormal myocardial fiber apoptosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T16:30:05Z" xsd:dateTime

[Term]
id: MP:0031645
name: increased myocardial fiber apoptosis
def: "increase in the number of adult cardiomyocytes undergoing programmed cell death" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated adult cardiomyocyte apoptosis" EXACT []
synonym: "elevated myocardial fiber apoptosis" EXACT []
synonym: "elevated myocardial fibre apoptosis" EXACT []
synonym: "increased adult cardiomyocyte apoptosis" EXACT []
synonym: "increased myocardial fibre apoptosis" EXACT []
is_a: MP:0003222 ! increased cardiomyocyte apoptosis
is_a: MP:0031643 ! abnormal myocardial fiber apoptosis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-01T16:33:40Z" xsd:dateTime

[Term]
id: MP:0031646
name: impotence
def: "persistent or recurrent inability to develop or to maintain a penile erection during sexual activity" [HP:0000802, https://www.ncbi.nlm.nih.gov/books/NBK562253/]
synonym: "absence of penile erection" EXACT []
synonym: "erectile dysfunction" BROAD []
synonym: "erectile impotence" EXACT []
synonym: "failure of penile erection" EXACT []
synonym: "male sexual impotence" EXACT []
is_a: MP:0001379 ! abnormal penile erection
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-08T11:58:29Z" xsd:dateTime

[Term]
id: MP:0031647
name: abnormal cerebrospinal fluid glucose level
def: "any deviation from the normal concentration of glucose in the cerebrospinal fluid" [HP:0031884]
synonym: "abnormal cerebrospinal fluid glucose concentration" EXACT []
synonym: "abnormal CSF glucose concentration" EXACT []
synonym: "abnormal CSF glucose level" EXACT []
is_a: MP:0002078 ! abnormal glucose homeostasis
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-22T13:40:43Z" xsd:dateTime

[Term]
id: MP:0031648
name: decreased cerebrospinal fluid glucose level
def: "less than the normal concentration of glucose in the cerebrospinal fluid" [HP:0011972, PMID:31399478]
synonym: "decreased CSF glucose concentration" EXACT []
synonym: "decreased CSF glucose level" EXACT []
synonym: "hypoglycorrhachia" EXACT []
synonym: "reduced cerebrospinal fluid glucose level" EXACT []
synonym: "reduced CSF glucose level" EXACT []
is_a: MP:0031647 ! abnormal cerebrospinal fluid glucose level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-22T13:46:49Z" xsd:dateTime

[Term]
id: MP:0031649
name: increased cerebrospinal fluid glucose level
def: "greater than the normal concentration of glucose in the cerebrospinal fluid" [HP:0031885]
synonym: "elevated cerebrospinal fluid glucose level" EXACT []
synonym: "elevated CSF glucose level" EXACT []
synonym: "hyperglycorrhachia" EXACT []
synonym: "increased CSF glucose concentration" EXACT []
synonym: "increased CSF glucose level" EXACT []
is_a: MP:0031647 ! abnormal cerebrospinal fluid glucose level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-22T13:51:43Z" xsd:dateTime

[Term]
id: MP:0031650
name: decreased mounting behavior
def: "a decreased display, frequency, or duration of mounting activity, with or without pelvic thrusting and intromission, occurring prior to ejaculation" [https://orcid.org/0000-0002-6490-7723]
synonym: "decreased mounting behaviour" EXACT []
synonym: "reduced mounting behavior" EXACT []
synonym: "reduced mounting behaviour" EXACT []
is_a: MP:0031629 ! abnormal mounting behavior
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-22T16:49:05Z" xsd:dateTime

[Term]
id: MP:0031651
name: increased mounting behavior
def: "an increased display, frequency, or duration of mounting activity, with or without pelvic thrusting and intromission, occurring prior to ejaculation" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated mounting behavior" EXACT []
synonym: "elevated mounting behaviour" EXACT []
synonym: "increased mounting behaviour" EXACT []
is_a: MP:0031629 ! abnormal mounting behavior
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-07-22T16:52:43Z" xsd:dateTime

[Term]
id: MP:0031652
name: abnormal brain calcium level
def: "any anomaly in the amount of calcium present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0020879 ! abnormal calcium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:14:12Z" xsd:dateTime

[Term]
id: MP:0031653
name: decreased brain calcium level
def: "a reduced amount of calcium in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain calcium level" EXACT []
is_a: MP:0014538 ! decreased calcium level
is_a: MP:0031652 ! abnormal brain calcium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:23:10Z" xsd:dateTime

[Term]
id: MP:0031654
name: increased brain calcium level
def: "an increased amount of calcium in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated brain calcium level" EXACT []
is_a: MP:0014537 ! increased calcium level
is_a: MP:0031652 ! abnormal brain calcium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:29:34Z" xsd:dateTime

[Term]
id: MP:0031655
name: abnormal brain magnesium level
def: "any anomaly in the amount of magnesium present in the brain tissue" [https://orcid.org/0000-0002-6490-7723]
is_a: MP:0002152 ! abnormal brain morphology
is_a: MP:0020883 ! abnormal magnesium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:41:27Z" xsd:dateTime

[Term]
id: MP:0031656
name: decreased brain magnesium level
def: "a reduced amount of magnesium in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced brain magnesium level" EXACT []
is_a: MP:0031655 ! abnormal brain magnesium level
is_a: MP:0031658 ! decreased magnesium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:46:02Z" xsd:dateTime

[Term]
id: MP:0031657
name: increased brain magnesium level
def: "an increased amount of magnesium in brain tissue compared to controls" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated brain magnesium level" EXACT []
is_a: MP:0031655 ! abnormal brain magnesium level
is_a: MP:0031659 ! increased magnesium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T07:52:57Z" xsd:dateTime

[Term]
id: MP:0031658
name: decreased magnesium level
def: "reduction in the concentration of magnesium in the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "reduced magnesium level" EXACT []
is_a: MP:0020883 ! abnormal magnesium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T08:01:32Z" xsd:dateTime

[Term]
id: MP:0031659
name: increased magnesium level
def: "increase in the concentration of magnesium in the body" [https://orcid.org/0000-0002-6490-7723]
synonym: "elevated magnesium level" EXACT []
is_a: MP:0020883 ! abnormal magnesium level
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-09T08:16:49Z" xsd:dateTime

[Term]
id: MP:0031660
name: prenatal lethality prior to heart atrial septation, incomplete penetrance
def: "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms, prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [https://orcid.org/0000-0002-6490-7723]
synonym: "partial prenatal lethality prior to heart atrial septation" EXACT []
is_a: MP:0011101 ! prenatal lethality, incomplete penetrance
is_a: MP:0013294 ! prenatal lethality prior to heart atrial septation
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-30T07:49:40Z" xsd:dateTime

[Term]
id: MP:0031661
name: prenatal lethality prior to heart atrial septation, complete penetrance
def: "death of all organisms of a given genotype in a population prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [https://orcid.org/0000-0002-6490-7723]
synonym: "complete prenatal lethality prior to heart atrial septation" EXACT []
is_a: MP:0011091 ! prenatal lethality, complete penetrance
is_a: MP:0013294 ! prenatal lethality prior to heart atrial septation
property_value: terms:contributor https://orcid.org/0000-0002-6490-7723
property_value: terms:date "2024-09-30T07:55:31Z" xsd:dateTime

[Term]
id: MP:3000001
name: abnormal gastrula morphology
def: "any structural anomaly of the pear shaped trilaminar embryonic stage in which the primititve streak elongates, the epiblast cells migrate medially towards the streak, enter the primitive groove and migrate laterally to organize into the intraembryonic mesoderm (epithelio-mesenchymal transition) between the embryonic ectoderm and primitive endoderm; the notochordal process forms and extends, and the disc becomes pear shaped as the notochordal process grows" [http://discovery.lifemapsc.com/library/review-of-medical-embryology/chapter-18-week-3-of-development-trilaminar-germ-disk-embryo-formation-and-gastrulation]
synonym: "abnormal trilaminar blastocyst morphology" EXACT []
synonym: "abnormal trilaminar disc morphology" RELATED []
synonym: "abnormal trilaminar disk morphology" RELATED []
synonym: "abnormal trilaminar embryonic disc morphology" EXACT []
synonym: "abnormal trilaminar embryonic disk morphology" EXACT []
synonym: "abnormal trilaminar germ disc morphology" EXACT []
synonym: "abnormal trilaminar germ disk morphology" EXACT []
is_a: MP:0002085 ! abnormal embryonic tissue morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: csmith
creation_date: 2014-06-26T15:11:51Z

[Term]
id: MP:3000002
name: obsolete abnormal skull morphology
def: "Any structural anomaly of a skull." [GOC:TermGenie]
property_value: terms:contributor https://orcid.org/0000-0001-5208-3432
is_obsolete: true
created_by: nvasilevsky
creation_date: 2014-07-01T01:03:12Z

[Term]
id: MP:3000003
name: abnormal Ebner's gland morphology
def: "any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete lingual lipase initiating the process of lipid hydrolysis in the mouth and empty their serous secretion into the base of the moats around the foliate and circumvallate papillae; their secretion presumably flushes material from the moat to enable the taste buds to respond rapidly to changing stimuli." [GOC:TermGenie, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal gustatory gland morphology" EXACT []
synonym: "abnormal Von Ebner's gland morphology" EXACT []
synonym: "posterior deep lingual gland" EXACT []
synonym: "posterior lingual serous gland" EXACT []
is_a: MP:0003791 ! abnormal minor salivary gland morphology
is_a: MP:0008052 ! abnormal serous gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: csmith
creation_date: 2014-12-04T20:40:06Z

[Term]
id: MP:3000004
name: abnormal nictitating membrane morphology
def: "any structural anomaly of the translucent fold of the mucous membrane of the conjunctiva present in some animals that can be drawn across the eye for protection and to moisten it while maintaining visibility; in many mammals, a small, vestigial portion of the membrane remains in the corner of the eye; in mice, the nictitating membrane is very small and composed of a very thin core of cartilage covered by loose connective tissue" [GOC:TermGenie, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal nictitans morphology" EXACT []
synonym: "abnormal palperbra tertia morphology" EXACT []
synonym: "abnormal third eyelid morphology" EXACT []
is_a: MP:0001340 ! abnormal eyelid morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: csmith
creation_date: 2014-12-04T20:44:25Z

[Term]
id: MP:3000005
name: abnormal lacrimal sac morphology
def: "any structural anomaly of the upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue" [GOC:TermGenie, https://orcid.org/0000-0002-6490-7723]
synonym: "abnormal lacrymal sac morphology" EXACT []
synonym: "abnormal saccus lacrimalis morphology" EXACT []
is_a: MP:0001346 ! abnormal lacrimal gland morphology
property_value: terms:contributor https://orcid.org/0000-0003-4606-0597
created_by: csmith
creation_date: 2014-12-04T20:44:33Z

[Typedef]
id: RO:0002503
name: towards

[Typedef]
id: RO:0002573
name: has modifier