Summative Diagnosis:
Cardiovascular phenotype:
Mutant 1: Heterotaxy with congenital heart disease (CHD): Double outlet right ventricle (DORV), atrioventricular (AVSD), common atrium, and ventricular septal defects (VSD), dual/bilateral inferior vena cava (IVC), coronary fistula, and ventricular non-compaction
Mutant 2: Interrupted aortic arch (IAA)

Non-cardiac phenotype:
Mutant 1: Abnormal thoracic and abdominal organ situs anomalies, such as dextrogastria, left lung isomerism, liver isomerism, and asplenia
Mutant 2: Micrognathia, cleft palate, hypoplastic thymus, malaligned sternal vertebra, as well as duplex and hydronephrotic kidneys

Phenotypic Similarity to Human Syndrome:
Mutant 1: Heterotaxy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Codes	Code Description
190	Heterotaxy syndrome
606	DORV + AVSD (AV canal)
1100	Atrioventricular canal (endocardial cushion defect)
1140	Common atrium
1300	Ventricular septal defect
1802	Excessive myocardial trabeculation or noncompaction
2230	Coronary fistula (arterio-venous or arterio-cameral)
2810	Inferior vena cava anomaly
3817	Abdominal situs ambiguous (abdominal heterotaxy)
4239	Left bronchial isomerism
4771	Asplenia
600	Double outlet right ventricle
1250	Interrupted aortic arch
2700	Abnormal aortic arch
4100	Skeletal, skin, muscle anomaly
4163	Micrognathia
4447	Hepatic malformation
4502	Hydronephrosis
4512	Renal malformation
4876	Cleft palate