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Glossary Term
Glossary Term Probe
Definition
  1. In molecular biology, a nucleic acid that has been labeled either radioactively or chemically that allows the detection of nucleic acids with sequence similarity in a sample by hybridization. Probes are used to detect DNA on membranes in Southern blots, to detect RNA on membranes in Northern blots, and either DNA or RNA in cytological preparations for in situ hybridization.
  2. In MGI, the term "probe" applies not only to nucleic acid probes detected as described above, but also to primers for PCR. This usage is not common outside of MGI.
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11/12/2024
MGI 6.24 		The Jackson Laboratory